M Cobo Marcos, J Comín-Colet, R de la Espriella, J Rubio Gracia, J L Morales-Rull, I Zegrí, P Llacer, P Diez-Villanueva, S Jiménez-Marrero, J de Juan Bagudá, C Ortiz Cortés, J Goirigolzarri-Artaza, J M García-Pinilla, E Barrios, S Del Prado Díaz, E Montero Hernández, M Sanchez-Marteles, J Nuñez
AIMS: Hypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy in the ambulatory setting have not been evaluated. We aimed to describe the design and baseline characteristics of the SALT-HF trial participants. METHODS AND RESULTS: 'Efficacy of Saline Hypertonic Therapy in Ambulatory Patients with HF' (SALT-HF) trial was a multicenter, double-blinded, and randomized study involving ambulatory patients who experienced worsening heart failure (WHF) without criteria for hospitalization...
February 21, 2024: ESC Heart Failure