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https://www.readbyqxmd.com/read/29228469/simultaneous-determination-of-etonogestrel-and-ethinyl-estradiol-in-human-plasma-by-uplc-ms-ms-and-its-pharmacokinetic-study
#1
Sneha G Nair, Daxesh P Patel, Frank J Gonzalez, Bhargav M Patel, Puran Singhal, Darshan V Chaudhary
A selective, sensitive and rapid ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of etonogestrel (ENG) and ethinyl estradiol (EE) in human plasma. The analytes and their deuterated internal standard, ENG-d7 and EE-d4 were extracted from plasma samples by solid phase extraction on HyperSep™ Retain PEP Cartridges. The chromatographic analysis was performed on ACQUITY UPLC HSS Cyano column, 100 A° (50 mm × 2.1 mm, 1.8 μm) column using gradient mobile phase, acetonitrile and 2...
December 11, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29228022/can-conditional-cash-transfers-improve-the-uptake-of-nutrition-interventions-and-household-food-security-evidence-from-odisha-s-mamata-scheme
#2
Kalyani Raghunathan, Suman Chakrabarti, Rasmi Avula, Sunny S Kim
There is considerable global evidence on the effectiveness of cash transfers in improving health and nutrition outcomes; however, the evidence from South Asia, particularly India, is limited. In the context of India where more than a third of children are undernourished, and where there is considerable under-utilization of health and nutrition interventions, it is opportune to investigate the impact of cash transfer programs on the use of interventions. We study one conditional cash transfer program, Mamata scheme, implemented in the state of Odisha, in India that targeted pregnant and lactating women...
2017: PloS One
https://www.readbyqxmd.com/read/29227273/-poisoning-by-psychopharmacological-drugs-in-azerbaijan-the-results-of-8-year-prospective-observation
#3
I Afandiyev, V Azizov
Acute poisoning of chemical etiology is a significant global public health problem. The aim of this study was the analysis of the toxicoepidemiological structure of psychopharmacological drugs poisoning in Azerbaijan. We collected and analyzed the data on all cases of acute poisoning by psychopharmacological drugs (codes of categories T42/T43 ICD-10) undergoing inpatient treatment at the Center of Clinical Toxicology in Baku, Azerbaijan in 2009-2016. The total number of patients with acute intoxication by psychopharmacological drugs was 3,413, which was 48...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29227171/evaluation-and-prediction-of-powder-flowability-in-pharmaceutical-tableting
#4
Claudia Hildebrandt, Srikanth R Gopireddy, Alexander K Fritsch, Thomas Profitlich, Regina Scherließ, Nora A Urbanetz
The focus of this study is to establish a characterization method determining the powder flowability in context of tableting. At first, flowability of different materials is measured using the ring shear tester, and its prediction from particle size is established. Next, the model die filling system is presented which is a modified version of previous studies. Using this system flowability of different materials is measured at varying die speeds. A new curve fit to assess die fill ratio vs die speed is suggested improving predictability, and a novel flowability metric, "Die Fill Index" (DFI), is derived...
December 11, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29226626/randomized-clinical-study-of-safety-pharmacokinetics-and-pharmacodynamics-of-ripk1-inhibitor-gsk2982772-in-healthy-volunteers
#5
Kathleen Weisel, Nicola E Scott, Debra J Tompson, Bartholomew J Votta, Sujith Madhavan, Kat Povey, Allen Wolstenholme, Monica Simeoni, Todd Rudo, Lauren Richards-Peterson, Tarjinder Sahota, J Gene Wang, John Lich, Joshua Finger, Adeline Verticelli, Michael Reilly, Peter J Gough, Philip A Harris, John Bertin, Mei-Lun Wang
GSK2982772 is a highly selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) being developed to treat chronic inflammatory diseases. This first-in-human study evaluated safety, tolerability, pharmacokinetics (PK), and exploratory pharmacodynamics (PD) of GSK2982772 administered orally to healthy male volunteers. This was a Phase I, randomized, placebo-controlled, double-blind study. In Part A, subjects received single ascending doses of GSK2982772 (0.1-120 mg) or placebo in a crossover design during each of 4 treatment periods...
December 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29225657/satisfaction-and-quality-of-life-of-allergic-patients-following-sublingual-five-grass-pollen-tablet-immunotherapy-in-spain
#6
Darío Antolín-Amerigo, Isabel A Tabar, Maria Del Mar Fernández-Nieto, Anna M Callejo-Melgosa, Francisco J Muñoz-Bellido, José C Martínez-Alonso, Jorge D Méndez-Alcalde, Marta Reche, Ana Rodríguez-Trabado, Ana Rosado-Ingelmo, Alicia Alonso-Gómez, Rosa Blanco-González, José A Alvarez-Fernandez, Isabel Botella, Ana Valls, Mercedes Cimarra, Carlos Blanco
Background: Five-grass pollen tablet is an effective and well-tolerated therapy for patients with allergic rhinoconjunctivitis (ARC). This trial sought to determine the satisfaction and health-related quality of life (HRQoL) of patients undergoing this treatment. Methods: This was a cross-sectional, multicentre, observational, naturalistic study, following a discontinuous pre- and co-seasonal five-grass pollen regimen over two seasons in Spain (2012, 2013). The HRQoL of the patients was measured with the specific Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) for adults, adolescent (AdolRQLQ), or paediatric (PRQLQ) patients...
2017: Drugs in Context
https://www.readbyqxmd.com/read/29225461/risperidone-mucoadhesive-buccal-tablets-formulation-design-optimization-and-evaluation
#7
Burak Çelik
The aim of this study was to design and optimize risperidone (RIS) mucoadhesive buccal tablets for systemic delivery as an alternative route. Direct compression method was used for the preparation of buccal tablets, and screening studies were conducted with different polymers to determine their effects on tablet characteristics. Carbopol® (CP) and sodium alginate (SA) were selected as two polymer types for further optimization studies by applying response surface methodology. Tablet hardness (TH), ex vivo residence time (RT), and peak detachment force (DF) from buccal mucosa were selected as three important responses...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29225131/role-of-tenofovir-alafenamide-taf-in-the-treatment-and-prophylaxis-of-hiv-and-hbv-infections
#8
REVIEW
Erik De Clercq
Tenofovir (TFV) is the cornerstone in the treatment and prophylaxis of HIV infections. It has been routinely used in its prodrug form TDF (tenofovir disoproxil fumarate) combined with emtricitabine ((-)FTC) and other antiretroviral agents. TDF has now been replaced by TAF (tenofovir alafenamide) which allows better uptake by the lymphoid tissue. In combination with elvitegravir (E), cobicistat (C), emtricitabine (F), TAF can be advocated as an STR (single tablet regimen, Genvoya®) for the treatment of HIV infections...
December 7, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29225098/xanthan-gum-as-a-rate-controlling-polymer-for-the-development-of-alcohol-resistant-matrix-tablets-and-mini-tablets
#9
Alessia Lazzari, Peter Kleinebudde, Klaus Knop
The vulnerability of controlled release formulations when co-ingested with alcohol represents a current major concern of regulatory agencies. Dose dumping might occur when drugs and/or excipients exhibit higher solubility in ethanolic solutions compared to water. In this study, xanthan gum was chosen as rate-controlling polymer for the development of alcohol resistant matrix formulations and theophylline as model drug. Two polymer particle sizes (75 and 180 µm) and concentrations (30 and 60% w/w) were used to assess their influence on the in-vitro drug release from directly compressed tablets and mini-tablets, in 0% and 40% ethanol for 2 hours (pH 1...
December 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29224920/-cognitive-doping-in-students-a-chim-er-ical-way-to-get-full-head
#10
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the requirements for memorization, increased performance and peer competition may encourage cognitive doping behaviors. We aimed to describe recent practices and the benefit/risk ratio of such behavior to discuss the different issues. The prevalence of cognitive doping among students was 1.3% to 33% according to the studies, depending on the country concerned and the definition of cognitive doping used. The therapeutic classes most frequently cited as being diverted were psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
November 22, 2017: Thérapie
https://www.readbyqxmd.com/read/29224648/effect-of-high-dose-oral-multivitamins-and-minerals-in-participants-not-treated-with-statins-in-the-randomized-trial-to-assess-chelation-therapy-tact
#11
Omar M Issa, Rhonda Roberts, Daniel B Mark, Robin Boineau, Christine Goertz, Yves Rosenberg, Eldrin F Lewis, Erminia Guarneri, Jeanne Drisko, Allan Magaziner, Kerry L Lee, Gervasio A Lamas
IMPORTANCE: In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high-dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with placebo. The regimen tested was substantially different from any vitamin regimen tested in prior clinical trials. OBJECTIVE: To explore these results, we performed detailed additional analyses of participants not on statins at enrollment in TACT...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29222475/suitability-of-various-chromatographic-and-spectroscopic-techniques-for-analysis-and-kinetic-degradation-study-of-trelagliptin
#12
Wafaa A Zaghary, Shereen Mowaka, Mostafa A Hassan, Bassam M Ayoub
Multifaceted comparative analytical methods for trelagliptin (TRL) were investigated, applied to ZAFATEK tablets and HPLC-UV was selected for a degradation kinetic study. UPLC-MS/MS (Method I), UPLC-UV (Method II), HPLC-UV (Method III), UHPLC-UV (Method IV) and direct UV (Method V) methods were developed. Methods (I-V) showed satisfactory results using TRL concentration ranges of 50-800 ng/mL, 2.5-80 μg/mL, 5-100 μg/mL, 5-100 μg/mL and 5-50 μg/mL, respectively. Multiple Reaction Monitoring (MRM) of the transition pairs of m/z 358...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221713/effect-of-grass-sublingual-tablet-immunotherapy-is-similar-in-children-and-adults-a-bayesian-approach-to-design-pediatric-sublingual-immunotherapy-trials
#13
Amarjot Kaur, David Skoner, Joseph Ibrahim, Qing Li, Richard F Lockey, Michael Blaiss, Albrecht Bufe, Jens Strodl Andersen, Giorgio Walter Canonica, Hendrik Nolte
BACKGROUND: Large sample sizes are needed for sublingual immunotherapy (SLIT) trials due to inherent data variability secondary to inconsistent allergen exposure. Obtaining large sample sizes for pediatric SLIT trials is challenging, but a Bayesian approach using prior adult data can reduce the necessary sample size. OBJECTIVE: To describe how a Bayesian framework utilizing prior information from adult trials can be used to improve pediatric SLIT clinical development...
December 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29220339/to-flavor-or-not-to-flavor-extemporaneous-omeprazole-liquid
#14
Monica C Chuong, Catherine A Taglieri, Stephen G Kerr
Omeprazole is a proton pump inhibitor used to treat the symptoms of gastro esophageal reflux disease, ulcers, excess stomach acid, infection with Helicobacter pylori, and to control the gastric side effects of various drugs. The approved dosage forms in the U.S. are powder in compounding kits, delayed-release granules for oral suspension, oral delayed-release tablets, and oral delayed-release capsules. An extemporaneously compounded unsweetened oral liquid method, published in the International Journal of Pharmaceutical Compounding, was found to be commonly used by pharmacists...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219169/pharmacokinetics-and-pharmacodynamics-of-sublingual-sufentanil-for-postoperative-pain-management
#15
REVIEW
T van de Donk, S Ward, R Langford, A Dahan
Achieving successful treatment of postoperative pain remains a challenge. Recently, a sufentanil sublingual tablet system has been developed for treatment of moderate-to-severe postoperative pain. The phenylpiperidine sufentanil is a potent analgesic that rapidly crosses the blood-brain barrier and selectively activates central μ-opioid receptors. The system makes use of a hand-held dispenser system, which contains forty 15-μg sufentanil sublingual micro-tablets. The patient can release one tablet at 20-min intervals using a unique radiofrequency adhesive tag, which is wrapped around the patient's thumb...
December 8, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29219168/between-evidence-and-commerce-the-case-of-sufentanil-sublingual-tablet-systems
#16
EDITORIAL
C Bantel, H C Laycock
No abstract text is available yet for this article.
December 8, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#17
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29217884/how-harmful-can-herbal-remedies-be-a-case-of-severe-acute-tubulointerstitial-nephritis
#18
P Beniwal, N Gaur, S K Singh, N Raveendran, V Malhotra
Acute interstitial nephritis (AIN) is a condition in which acute kidney injury (AKI) is characterized by the histological finding of interstitial inflammation. Hyponidd is an ayurvedic drug containing Momordica charantia, Gymnema sylvestre, Swertia chirata, etc., used for the treatment of Type 2 diabetes mellitus (DM) and polycystic ovarian disease as an insulin sensitizer. There are no case reports of AIN caused by this drug yet. We report a biopsy-proven case of AKI due to severe AIN associated with the use of hyponidd tablet in a 60-year-old male with DM and hypertension...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29217471/3d-printing-of-high-drug-loaded-dosage-forms-using-thermoplastic-polyurethanes
#19
G Verstraete, A Samaro, W Grymonpré, V Vanhoorne, B Van Snick, M N Boone, T Hellemans, L Van Hoorebeke, J P Remon, C Vervaet
It was the aim of this study to develop high drug loaded (>30%, w/w), thermoplastic polyurethane (TPU)-based dosage forms via fused deposition modelling (FDM). Model drugs with different particle size and aqueous solubility were pre-processed in combination with diverse TPU grades via hot melt extrusion (HME) into filaments with a diameter of 1.75 ± 0.05 mm. Subsequently, TPU-based filaments which featured acceptable quality attributes (i.e. consistent filament diameter, smooth surface morphology and good mechanical properties) were printed into tablets...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29216620/physicochemical-stability-of-an-oral-suspension-of-trimethoprim-20-mg-ml-in-combination-with-sulfadiazine-200-mg-ml-in-pcca-base-suspendit
#20
Richard A Graves, Kelly V Phan, Levon A Bostanian, Tarun K Mandal, Yashoda V Pramar
Trimethoprim is a diaminopyrimidine antibacterial agent that, like sulfonamides, inhibits bacterial folic acid synthesis, but at a different stage in the metabolic pathway. It has a similar spectrum of activity to the sulfonamides and is given by mouth or by injection, either alone or in conjunction with a sulfonamide, such as sulfadiazine. Sulfadiazine is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. The combination of the two drugs produces a synergistic effect against both Gram-positive and Gram-negative aerobic bacteria, by inhibiting enzymes in the folic acid pathways, which in turn inhibits bacterial thymidine synthesis...
September 2017: International Journal of Pharmaceutical Compounding
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