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https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#1
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667066/population-exposure-response-analysis-of-cabozantinib-efficacy-and-safety-endpoints-in-patients-with-renal-cell-carcinoma
#2
Steven Lacy, Jace Nielsen, Bei Yang, Dale Miles, Linh Nguyen, Matt Hutmacher
BACKGROUND: In the phase III METEOR trial, tyrosine kinase inhibitor cabozantinib significantly improved progression-free survival (PFS), objective response rate (ORR), and overall survival compared to everolimus in patients with advanced renal cell carcinoma (RCC) who had received prior VEGFR inhibitor therapy. In METEOR, RCC patients started at a daily 60-mg cabozantinib tablet (Cabometyx™) dose but could reduce to 40- or 20-mg to achieve a tolerated exposure. OBJECTIVES AND METHODS: Exposure-response (ER) models were developed to characterize the relationship between cabozantinib at clinically relevant exposures in RCC patients enrolled in METEOR and efficacy (PFS and tumor response) and safety endpoints...
April 17, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29666045/general-practitioners-perspective-on-ehealth-and-lifestyle-change-qualitative-interview-study
#3
Carl Joakim Brandt, Gabrielle Isidora Søgaard, Jane Clemensen, Jens Sndergaard, Jesper Bo Nielsen
BACKGROUND: Wearables, fitness apps, and patient home monitoring devices are used increasingly by patients and other individuals with lifestyle challenges. All Danish general practitioners (GPs) use digital health records and electronic health (eHealth) consultations on a daily basis, but how they perceive the increasing demand for lifestyle advice and whether they see eHealth as part of their lifestyle support should be explored further. OBJECTIVE: This study aimed to explore GPs' perspectives on eHealth devices and apps and the use of eHealth in supporting healthy lifestyle behavior for their patients and themselves...
April 17, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29665997/lower-urinary-tract-symptoms-what-s-new-in-medical-treatment
#4
REVIEW
Benoit Peyronnet, Benjamin M Brucker, Martin C Michel
CONTEXT: Pharmacological treatment is a cornerstone in the management of patients with lower urinary tract symptoms (LUTS). OBJECTIVE: To review emerging evidence in the medical treatment of LUTS. EVIDENCE ACQUISITION: An Embase/Pubmed-based literature search was conducted in December 2017, screening for randomized controlled trials (RCTs), prospective and retrospective series, animal model studies, and reviews on medical treatment of LUTS...
April 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29664159/reading-aids-for-adults-with-low-vision
#5
REVIEW
Gianni Virgili, Ruthy Acosta, Sharon A Bentley, Giovanni Giacomelli, Claire Allcock, Jennifer R Evans
BACKGROUND: The purpose of low-vision rehabilitation is to allow people to resume or to continue to perform daily living tasks, with reading being one of the most important. This is achieved by providing appropriate optical devices and special training in the use of residual-vision and low-vision aids, which range from simple optical magnifiers to high-magnification video magnifiers. OBJECTIVES: To assess the effects of different visual reading aids for adults with low vision...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29663959/quality-assurance-of-rifampicin-containing-fixed-drug-combinations-in-south-africa-dosing-implications
#6
R Court, M T Chirehwa, L Wiesner, B Wright, W Smythe, N Kramer, H McIlleron
SETTING: Rifampicin (RMP) drives treatment response in drug-susceptible tuberculosis. Low RMP concentrations increase the risk of poor outcomes, and drug quality needs to be excluded as a contributor to low RMP exposure. OBJECTIVES AND DESIGN: We performed an open-label, three-way cross-over study of three licensed RMP-containing formulations widely used in South Africa to evaluate the bioavailability of RMP in a two-drug fixed-dose combination tablet (2FDC) and a four-drug FDC (4FDC) against a single-drug reference...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663624/a-cross-sectional-study-of-agreement-between-the-hospital-anxiety-and-depression-scale-patient-and-radiation-oncologist-reported-single-item-assessment-of-depression-and-anxiety
#7
Lisa Mackenzie, Mariko Carey, Eiji Suzuki, Michio Yoshimura, Masakazu Toi, Catherine D'Este, Rob Sanson-Fisher
OBJECTIVE: To describe, among radiation oncology patients: The proportion likely to be experiencing symptoms of depression and anxiety as identified by: a) the Hospital Anxiety and Depression Scale (HADS; standardised tool); b) Patient-reported single-items (ultra-short tool); and c) Radiation oncologist-reported single items (clinician judgement); Preferences for being offered psychological support; and Agreement between single-item measures and the HADS. METHODS: Adult cancer patients (n = 152; consent rate 58%) receiving radiotherapy completed a touchscreen tablet survey assessing symptoms of anxiety and depression (HADS and a single-item tool) and support preferences...
April 16, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29663595/adult-neurogenesis-affects-motivation-to-obtain-weak-but-not-strong-reward-in-operant-tasks
#8
Rose-Marie Karlsson, Alice S Wang, Anup N Sonti, Heather A Cameron
Decreased motivation to seek rewards is a key feature of mood disorders that correlates with severity and treatment outcome. This anhedonia, or apathy, likely reflects impairment in reward circuitry, but the specific neuronal populations controlling motivation are unclear. Granule neurons generated in the adult hippocampus have been implicated in mood disorders, but are not generally considered as part of reward circuits. We investigated a possible role of these new neurons in motivation to work for food and sucrose rewards in operant conditioning tasks using GFAP-TK pharmacogenetic ablation of adult neurogenesis in both rats and mice...
April 16, 2018: Hippocampus
https://www.readbyqxmd.com/read/29663288/in-vitro-in-vivo-predictive-dissolution-permeation-absorption-dynamics-of-highly-permeable-drug-extended-release-tablets-via-drug-dissolution-absorption-simulating-system-and-ph-alteration
#9
Zi-Qiang Li, Shuang Tian, Hui Gu, Zeng-Guang Wu, Makafui Nyagblordzro, Guo Feng, Xin He
Each of dissolution and permeation may be a rate-limiting factor in the absorption of oral drug delivery. But the current dissolution test rarely took into consideration of the permeation property. Drug dissolution/absorption simulating system (DDASS) valuably gave an insight into the combination of drug dissolution and permeation processes happening in human gastrointestinal tract. The simulated gastric/intestinal fluid of DDASS was improved in this study to realize the influence of dynamic pH change on the complete oral dosage form...
April 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29663287/influence-of-material-properties-on-the-effectiveness-of-glidants-used-to-improve-the-flowability-of-cohesive-pharmaceutical-powders
#10
Divya Sunkara, Maxx Capece
This study investigated the effect of material properties, primarily particle size and surface energy, on the effectiveness of glidants used for the purpose of flowability enhancement. Three pharmaceutical grade glidants (Aerosil 200, Aerosil R972, and Cab-O-Sil M5P) were evaluated and blended with various pharmaceutical actives as well as cohesive excipients common to capsule and tablet formulation. Flowability enhancement was characterized by the flow function coefficient (ff c ). An industry-relevant mixer (Turbula mixer) and a highly efficient and effective mixer (LabRAM vibratory mixer) were used to further understand the effect of material properties on glidant effectiveness...
April 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29662734/effect-of-a-water-extract-of-curcuma-longa-on-emotional-states-in-healthy-participants
#11
Kengo Kawasaki, Koutarou Muroyama, Shinji Murosaki
Physiological symptoms of mood disturbances, such as fatigue or anxiety, are closely related to inflammation in the central nervous system or the whole body. Curcuma longa is widely used as a dietary spice and has been reported to have anti-inflammatory activity. To investigate the effect of a water extract of C. longa (WEC) on emotional states, a randomized, double-blind, placebo-controlled, parallel-group study was conducted with healthy participants. Forty-eight participants were randomly assigned to receive five tablets containing 150 mg WEC and 0...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29662525/video-conferencing-telehealth-linkage-attempts-to-schools-to-facilitate-mental-health-consultation
#12
John D McLennan
Objective: Telehealth to schools may be a strategic approach to expand child mental health service delivery, however, there are only a few published examples. This report describes video-conferencing telehealth linkage attempts to schools to facilitate mental health consultation. Methods: A series of synchronous video-conferencing linkage strategies were attempted to connect a mental health consultation service to multiple schools in a Canadian setting. Consultation to support the implementation of the Daily Report Card, for students with attentional and behavioural problems, was the core content of this pilot linkage attempt...
April 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29661702/adolescent-cancer-patients-perceived-quality-of-cancer-care-the-roles-of-patient-engagement-and-supporting-independence
#13
Elizabeth J Siembida, Nina S Kadan-Lottick, Kerry Moss, Keith M Bellizzi
OBJECTIVES: A lack of focus on variation in engagement among cancer populations of differing developmental stages led us to examine the associations between patient engagement, the patient-provider relationship, cognitive development, readiness to transition to adulthood (transitional readiness) and perceived quality of care. METHODS: A sample of 101 adolescent cancer patients (diagnosed 10-20 years) completed survey items concerning patient engagement, dimensions of the patient-provider relationship, cognitive development, transitional readiness, and demographic characteristics using an iPad/tablet during a routine clinic visit...
April 10, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29660684/determination-of-diclofenac-sodium-by-resonance-light-scattering-method-using-silver-nanoparticles-as-probe
#14
Tao Liu, Zhihai Xie, Qing Liu
A sensitive, simple and novel method was developed to determine diclofenac sodium (DS) using silver nanoparticles (AgNPs) as probe by resonance light scattering (RLS) technique. It was found that DS could quench the RLS intensity of AgNPs. Moreover, the decrease in RLS intensity was linearly correlated to the concentration of DS over the range of 0.01-2.0μgmL-1 . DS can be measured in a short time (5min) without any complicated or time-consuming sample pretreatment process. Parameters that affect the RLS intensities such as pH, concentration of AgNPs, reaction time, electrolyte concentration, and coexisting substances were systematically investigated and optimized...
April 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29660665/investigation-of-anti-hepatitis-c-virus-sofosbuvir-and-daclatasvir-in-pure-form-human-plasma-and-human-urine-using-micellar-monolithic-hplc-uv-method-and-application-to-pharmacokinetic-study
#15
Dalia W Zidan, Wafaa S Hassan, Manal S Elmasry, Abdalla A Shalaby
Simultaneous determination of sofosbuvir (SOF), and daclatasvir (DAC) in their dosage forms, human urine and human plasma using simple and rapid micellar high performance liquid chromatographic method coupled with UV detection (HPLC-UV) had been developed and validated. These drugs are described as co-administered for treatment of Hepatitis C virus (HCV). HCV is the cause of Hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma) and lymphomas in humans. Separation and quantitation were carried out on anonyx™ C8 monolithic (100 × 4...
April 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29660643/gender-specific-associations-of-depression-and-anxiety-symptoms-with-mental-rotation
#16
Chiaki Oshiyama, Chihiro Sutoh, Hiroyasu Miwa, Satoshi Okabayashi, Hiroyuki Hamada, Daisuke Matsuzawa, Yoshiyuki Hirano, Tetsuya Takahashi, Shin-Ichi Niwa, Manabu Honda, Kazuyuki Sakatsume, Takuichi Nishimura, Eiji Shimizu
BACKGROUND: Men score higher on mental rotation tasks compared to women and suffer from depression and anxiety at half the rate of women. The objective of this study was to confirm the gender-specific effects of depression and anxiety on mental rotation performance. METHODS: We collected data in non-experimental conditions from 325 university students at three universities. Participants completed rating scales of depressive and anxiety symptoms, and then simultaneously performed a mental rotation task using tablet devices...
April 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29660383/dosage-form-modification-and-oral-drug-delivery-in-older-people
#17
Esther T L Lau, Kathryn J Steadman, Julie A Y Cichero, Lisa M Nissen
Many people cannot swallow whole tablets and capsules. The cause ranges from difficulties overriding the natural instinct to chew solids/foodstuff before swallowing, to a complex disorder of swallowing function affecting the ability to manage all food and fluid intake. Older people can experience swallowing difficulties because of co-morbidities, age-related physiological changes, and polypharmacy. To make medicines easier to swallow, many people will modify the medication dosage form e.g. split or crush tablets, and open capsules...
April 13, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29659913/a-randomized-double-blind-non-inferiority-study-of-hydromorphone-hydrochloride-immediate-release-tablets-versus-oxycodone-hydrochloride-immediate-release-powder-for-cancer-pain-efficacy-and-safety-in-japanese-cancer-patients
#18
Satoshi Inoue, Yoji Saito, Satoru Tsuneto, Etsuko Aruga, Hiroshi Takahashi, Mitsutoshi Uemori
Background: Hydromorphone is a standard opioid analgesic for cancer pain that, prior to this study, was not approved in Japan, where options for opioid switching are limited. We aimed to investigate the efficacy and safety of hydromorphone (DS-7113b) immediate-release tablets in opioid-naïve cancer patients with moderate to severe cancer pain. Methods: Multicenter, active-controlled, randomized, double-blind, parallel-group, non-inferiority study of 183 cancer patients over 20 years of age at 50 clinical sites in Japan...
April 12, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29659464/transitioning-patients-with-iron-overload-from-exjade-to-jadenu
#19
Sara M Tinsley, Christine M Hoehner-Cooper
Iron overload is a concern for patients who require chronic transfusions as a result of inherited or acquired anemias, including sickle cell disease, thalassemia, and myelodysplastic syndromes. Iron chelation therapy (ICT) is the primary treatment for iron overload in these patients. The ICT deferasirox, which has been available as an oral dispersible tablet for liquid suspension, is now also available as a once-daily, film-coated tablet (FCT). Deferasirox FCT allows greater convenience and may be associated with fewer gastrointestinal side effects versus the original formulation...
May 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29659193/pharmacologic-and-pharmacodynamic-equivalence-of-2-formulations-of-orlistat
#20
Steven Johnson, Susan M Schwartz
We sought to establish the bioequivalence of 2 weight-loss aids: orlistat 27-mg chewable tablet and orlistat 60-mg capsule, measured pharmacodynamically as percentage fecal fat excretion. Two open-label, single-center, randomized, 3-period, 3-treatment crossover studies were conducted in adults with body mass index 25-33 kg/m2 . For each 9-day treatment period, subjects received orlistat 27-mg chewable tablet, 60-mg capsule, or 120-mg capsules (2 60-mg capsules) 3 times daily; a 2-day washout separated treatments...
April 16, 2018: Clinical Pharmacology in Drug Development
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