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https://www.readbyqxmd.com/read/29040548/european-society-of-cardiology-smartphone-and-tablet-applications-for-patients-with-atrial-fibrillation-and-their-health-care-providers
#1
Dipak Kotecha, Winnie W L Chua, Larissa Fabritz, Jeroen Hendriks, Barbara Casadei, Ulrich Schotten, Panos Vardas, Hein Heidbuchel, Veronica Dean, Paulus Kirchhof
We are in the midst of a digital revolution in health care, although the application of new and useful technology in routine clinical practice is variable. The Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly (CATCH ME) Consortium, in collaboration with the European Society of Cardiology (ESC), has funded the creation of two applications (apps) in atrial fibrillation (AF) for use in smartphones and tablets. The patient app aims to enhance patient education, improve communication between patients and health care professionals, and encourage active patient involvement in the management of their condition...
October 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29036427/impact-of-achieved-blood-pressure-on-renal-function-decline-and-first-stroke-in-hypertensive-patients-with-chronic-kidney-disease
#2
Youbao Li, Min Liang, Chongfei Jiang, Guobao Wang, Jianping Li, Yan Zhang, Fangfang Fan, Ningling Sun, Yiming Cui, Mingli He, Genfu Tang, Delu Yin, Xiaoshu Cheng, Binyan Wang, Yong Huo, Xin Xu, Fan Fan Hou, Xiping Xu, Xianhui Qin
Background: The effect of achieved blood pressure (BP) on first stroke and renal function decline among hypertensive patients with mild to moderate chronic kidney disease (CKD) is still uncertain. Methods: In total, 3230 hypertensive patients with estimated glomerular filtration rate 30-60 mL/min/1.73 m 2 and/or proteinuria were included in the present analyses. Eligible participants were randomly assigned to a daily treatment of a combined enalapril 10 mg and folic acid 0...
September 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29036348/characterisation-of-the-graphite-moderated-thermal-neutron-field-at-cmi
#3
Zdenek Vykydal, Miloslav Králík
The graphite pile was set up at CMI to provide reference thermal neutron field for metrology and dosimetry purposes. It consists of three Pu-Be and three Am-Be radionuclide sources located in a 1.95 m (width) × 1.95 m (length) × 2.0 m (height) graphite moderator block. The neutron field in the volume of the experimental channel with dimensions of 40 cm × 40 cm × 135 cm (depth) was characterised experimentally and by Monte-Carlo calculations. Neutron fluence was determined by the activation of gold foils and Manganese tablets irradiated in nine different positions and by two 3He detectors of different construction irradiated in one position (bare and covered in three spherical PE moderators of 3, 3...
September 29, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036256/pharmacokinetic-comparison-of-once-daily-topical-minocycline-foam-4-vs-oral-minocycline-for-moderate-to-severe-acne
#4
Terry M Jones, Herman Ellman, Tina deVries
OBJECTIVE: To characterize minocycline pharmacokinetics and relative bioavailability following multiple-dose topical administration of minocycline hydrochloride (HCl) foam 4% (FMX101 4%) as compared with single-dose oral administration of minocycline HCl extended-release tablets (Solodyn®) in subjects with moderate-to-severe acne. METHODS: A Phase 1, single-center, nonrandomized, open-label, active-controlled, 2-period, 2-treatment crossover clinical study. The study included 30 healthy adults (mean age, 22...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29035217/oasis-procedurally-generated-social-virtual-spaces-from-3d-scanned-real-spaces
#5
Misha Sra, Sergio Garrido-Jurado, Pattie Maes
We present Oasis, a novel system for automatically generating immersive and interactive virtual reality environments for single and multiuser experiences. Oasis enables real-walking in the generated virtual environment by capturing indoor scenes in 3D and mapping walkable areas. It makes use of available depth information for recognizing objects in the real environment which are paired with virtual counterparts to leverage the physicality of the real world, for a more immersive virtual experience. Oasis allows co-located and remotely located users to interact seamlessly and walk naturally in a shared virtual environment...
October 13, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29034453/avp-825-sumatriptan-nasal-powder-reduces-nausea-compared-to-sumatriptan-tablets-results-of-the-compass-randomized-clinical-trial
#6
Richard B Lipton, James S McGinley, Kenneth J Shulman, Stephen D Silberstein, R J Wirth, Dawn C Buse
BACKGROUND: Migraine-related nausea is associated with significant disability, increased burden of disease, and personal distress. Nausea can lead to delays or avoidance of initiating oral migraine treatment, sometimes resulting in treatment failures and poor outcomes. Nausea is often a symptom of migraine, but nausea may also be a consequence of treatment (ie, treatment emergent nausea [TEN]). Relieving nausea and minimizing TEN are important goals in acute migraine therapy. METHODS: We analyzed data from the COMPASS study, a randomized, double blind, double-dummy, comparative efficacy study that contrasted two active treatments, AVP-825 (breath-powered intranasal delivery of powdered sumatriptan 22 mg) and oral sumatriptan tablets (100 mg)...
October 16, 2017: Headache
https://www.readbyqxmd.com/read/29033547/new-tablet-formulation-of-tacrolimus-with-smaller-interindividual-variability-may-become-a-better-treatment-option-than-the-conventional-capsule-formulation-in-organ-transplant-patients
#7
Yu Kyong Kim, Anhye Kim, Shin Jung Park, Howard Lee
To evaluate the pharmacokinetic (PK) and tolerability profiles of a new tablet formulation of tacrolimus and its interindividual variability (IIV) in the systemic exposure, and to compare them with those of the conventional capsule formulation, a randomized, open-label, two-treatment, two-period, two-sequence, crossover study was performed in 47 healthy males. The capsule or tablet formulation of tacrolimus was orally administered, and serial blood samples were collected up to 96 hours after dosing. Whole-blood tacrolimus concentration was determined using liquid chromatography-tandem mass spectrometry...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29031980/quality-by-design-qbd-approach-to-optimize-the-formulation-of-a-bilayer-combination-tablet-telmiduo-%C3%A2-manufactured-via-high-shear-wet-granulation
#8
Ah Ram Lee, Seok Young Kwon, Du Hyung Choi, Eun Seok Park
A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated based on a Quality by Design (QbD) approach. The control and response factors were determined based on primary knowledge and the target values of the control tablet (Twynsta(®)). A D-optimal mixture design was used to obtain the optimal formulations in terms of D-mannitol, crospovidone, and MCC for the telmisartan layer, and CCM-Na, PVP K25, and Prosolv for the amlodipine layer. The quantitative effects of the different formulation factors on the response factors were accurately predicted using the equations of best fit and a strong linearity was observed between the predicted and actual values of the response factors...
October 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29031784/isobarictags-for-relative-and-absolute-quantitation-itraq-based-proteomics-for-the-investigation-of-the-effect-of-huganqingzhi-on-non-alcoholic-fatty-liver-disease-in-rats
#9
Fan Xia, Xiaorui Yao, Waijiao Tang, Chunxin Xiao, Miaoting Yang, Benjie Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Hugan Qingzhi tablet (HQT), a traditional Chinese medicine formula has been adopted for preventing and treating nonalcoholic fatty liver disease (NAFLD). AIM: In order to explore the anti-NAFLD mechanisms of HQT, iTRAQ-based proteomics was employed to investigate the expression profiles of proteins in NAFLD rats induced by high-fat diet after HQT treatment. MATERIALS AND METHODS: The NAFLD rat model was administration of high-fat diet (HFD) for 12weeks and administering HQT in a daily basis to the HFD groups...
October 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29031581/parent-perceptions-of-mobile-device-use-among%C3%A2-preschool-aged-children-in-rural-head%C3%A2-start-centers
#10
Morgan McCloskey, Susan L Johnson, Cristen Benz, Darcy A Thompson, Barbara Chamberlin, Lauren Clark, Laura L Bellows
OBJECTIVE: To describe child use and parents' beliefs and comfort with young children's use of mobile devices in low-income, rural communities. METHODS: This was a descriptive, cross-sectional study. The survey, which consisted of 18 multiple-part questions, was distributed to families at 5 Head Start/preschool centers in Colorado. RESULTS: In total, 192 surveys were returned (28.5% response rate). Most children (92%) used a smartphone or tablet at some frequency and most parents (90%) had downloaded apps specifically for their child...
October 11, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29031170/a-dose-escalation-study-of-bi-daily-once-weekly-oral-docetaxel-either-as-modradoc001-or-modradoc006-combined-with-ritonavir
#11
Vincent A de Weger, Frederik E Stuurman, Jeroen J M A Hendrikx, Johannes J Moes, Emilia Sawicki, Alwin D R Huitema, Bastiaan Nuijen, Bas Thijssen, Hilde Rosing, Marianne Keessen, Marja Mergui-Roelvink, Jos H Beijnen, Jan H M Schellens, Serena Marchetti
INTRODUCTION: Two solid dispersions of docetaxel (denoted ModraDoc001 capsule and ModraDoc006 tablet (both 10 mg)) were co-administered with 100 mg ritonavir (/r) and investigated in a bi-daily once weekly (BIDW) schedule. Safety, maximum tolerated dose (MTD), pharmacokinetics (PK) and preliminary activity were explored. METHODS: Adult patients with metastatic solid tumours were included in two dose-escalation arms. PK sampling was performed during the first week and the second or third week...
October 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29030583/catastrophic-failure-of-nacre-under-pure-shear-stresses-of-torsion
#12
Saleh Alghamdi, Ting Tan, Christopher Hale-Sills, Floyd Vilmont, Tian Xia, Jie Yang, Dryver Huston, Mandar Dewoolkar
Nacre, a composite made from biogenic aragonite and proteins, exhibits excellent strength and toughness. Here, we show that nacreous sections can exhibit complete brittle fracture along the tablet interfaces at the proportional limit under pure shear stresses of torsion. We quantitatively separate the initial tablet sliding primarily resisted by nanoscale aragonite pillars from the following sliding resisted by various microscale toughening mechanisms. We postulate that the ductility of nacre can be limited by eliminating tablet interactions during crack propagations...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030305/entirely-s-protected-chitosan-a-promising-mucoadhesive-excipient-for-metronidazole-vaginal-tablets
#13
Noemi Lupo, Benjamin Fodor, Ijaz Muhammad, Muhammad Yaqoob, Barbara Matuszczak, Andreas Bernkop-Schnürch
AIM: Synthesis and evaluation of an entirely S-protected chitosan as mucoadhesive excipient for vaginal drug delivery. METHODS: N-acetyl-cysteine was linked to 6-mercaptonicotinamide via disulphide exchange reaction. The obtained ligand, NAC-6-MNA, was subsequently attached to chitosan by carbodiimide mediated amide bond formation in two concentrations. The synthesized S-protected chitosan was chemically characterized and mucoadhesive properties and stability against oxidation were investigated...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29030289/thermal-properties-of-compacted-pharmaceutical-excipients
#14
Alexander Krok, Nuno Vitorino, Jianyi Zhang, Jorge Ribeiro Frade, Chuan-Yu Wu
Thermal properties of powders are critical material attributes that control temperature rise during tableting and roll compaction. In this study, various analytical methods were used to measure the thermal properties of widely used pharmaceutical excipients including microcrystalline cellulose (MCC) of three different grades (Avicel PH 101; Avicel PH 102 and Avicel DG), lactose and mannitol. The effect of relative density on the measured thermal properties was investigated by compressing the powders into specimen of different relative densities...
October 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29030242/orodispersible-dosage-forms-biopharmaceutical-improvements-and-regulatory-requirements
#15
REVIEW
Francesco Cilurzo, Umberto M Musazzi, Silvia Franzé, Francesca Selmin, Paola Minghetti
Orodispersible dosage forms have a growing presence in the pharmaceutical market because their administration can improve the bioavailability of some drugs and their prescription can ameliorate patient adherence and/or compliance. Here, we review the main features of orodispersible tablets, including oral lyophilisates, and orodispersible films along with their main production technologies. We summarize the bioavailability data and critically discussed their potential to improve patient adherence and/or compliance...
October 13, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29030227/exploring-the-feasibility-of-obtaining-mifepristone-and-misoprostol-from-the-internet
#16
Chloe Murtagh, Elisa Wells, Elizabeth G Raymond, Francine Coeytaux, Beverly Winikoff
OBJECTIVES: We aimed to document the experience of buying abortion pills from online vendors that do not require a prescription and to evaluate the active ingredient content of the pills received. STUDY DESIGN: We searched the internet to identify a convenience sample of websites that sold mifepristone and misoprostol to purchasers in the United States and attempted to order these products. We documented price, shipping time and other aspects of ordering. We sent the samples received to a testing laboratory that measured the amount of active ingredient in individual tablets...
October 10, 2017: Contraception
https://www.readbyqxmd.com/read/29030199/effect-of-iodine-supplementation-in-pregnant-women-on-child-neurodevelopment-a-randomised-double-blind-placebo-controlled-trial
#17
Sueppong Gowachirapant, Nidhi Jaiswal, Alida Melse-Boonstra, Valeria Galetti, Sara Stinca, Ian Mackenzie, Susan Thomas, Tinku Thomas, Pattanee Winichagoon, Krishnamachari Srinivasan, Michael B Zimmermann
BACKGROUND: Iodine deficiency during pregnancy might be associated with reduced intelligence quotient (IQ) score in offspring. We assessed the effect of iodine supplementation in mildly iodine-deficient pregnant women on neurodevelopment of their offspring in areas where schoolchildren were iodine sufficient. METHODS: In this randomised, placebo-controlled trial, pregnant women in Bangalore, India, and Bangkok, Thailand, were randomly assigned (1:1) to receive 200 μg iodine orally once a day or placebo until delivery...
October 10, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29030043/quality-of-anthelminthic-medicines-available-in-jimma-ethiopia
#18
Sileshi Belew, Sultan Suleman, Evelien Wynendaele, Matthias D'Hondt, Anne Kosgei, Luc Duchateau, Bart De Spiegeleer
Soil-transmitted helminthiasis and schistosomiasis are major public health problems in Ethiopia. Mass deworming of at-risk population using a single dose administration of 400mg albendazole (ABZ) or 500mg mebendazole (MBZ) for treatment of common intestinal worms and 40mg of praziquantel (PZQ) per kg body weight for treatment of schistosomiasis is one of the strategies recommended by World Health Organization (WHO) in order to control the morbidity of soil-transmitted helminthiasis and schistosomiasis. Since storage condition, climate, way of transportation and distribution route could all affect the quality of medicines, regular assessment by surveys is very critical to ensure the therapeutic outcome, to minimize risk of toxicity to the patient and resistance of parasites...
October 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29029732/determination-of-cyanocobalamin-by-isotope-dilution-lc-ms-ms
#19
Lucia D'Ulivo, Lu Yang, Jianfu Ding, Enea Pagliano, Donald M Leek, Marie-Pier Thibeault, Zoltán Mester
Cyanocobalamin (CNCbl) is an active form of vitamin B12, commonly employed for the preparation of multivitamin supplements and fortified food. In this study, we present a novel analytical method for its determination based on stable isotope dilution liquid chromatography electrospray tandem mass spectrometry (ID LC-MS/MS). Isotopically enriched (13)C(15)NCbl was synthesized in-house and used as internal standard. The method was validated using NIST SRM 3280 multivitamin reference material and by comparison with an independent methodology based on LC-ICPMS...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029106/iatrogenic-cushing-syndrome-in-a-child-with-congenital-adrenal-hyperplasia-erroneous-compounding-of-hydrocortisone
#20
Julia E Barillas, Daniel Eichner, Ryan Van Wagoner, Phyllis W Speiser
Context: Patients with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) require lifelong treatment with glucocorticoids. In growing children the drug of choice is hydrocortisone. Commercially available hydrocortisone tablets do not conform to very low doses prescribed to infants and toddlers, and compounded hydrocortisone is often dispensed to meet therapeutic needs. However, safety, efficacy and uniformity of compounded products are not tested. We report a case of Cushing syndrome in a child with CAH who was inadvertently receiving excessive hydrocortisone in compounded form...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
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