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https://www.readbyqxmd.com/read/29474502/validation-of-the-portable-air-smart-spirometer
#1
Cristina Ramos Hernández, Marta Núñez Fernández, Abel Pallares Sanmartín, Cecilia Mouronte Roibas, Luz Cerdeira Domínguez, Maria Isabel Botana Rial, Nagore Blanco Cid, Alberto Fernández Villar
BACKGROUND: The Air-Smart Spirometer is the first portable device accepted by the European Community (EC) that performs spirometric measurements by a turbine mechanism and displays the results on a smartphone or a tablet. METHODS: In this multicenter, descriptive and cross-sectional prospective study carried out in 2 hospital centers, we compare FEV1, FVC, FEV1/FVC ratio measured with the Air Smart-Spirometer device and a conventional spirometer, and analyze the ability of this new portable device to detect obstructions...
2018: PloS One
https://www.readbyqxmd.com/read/29474436/rapid-assessment-of-viable-but-non-culturable-bacillus-coagulans-mtcc-5856-in-commercial-formulations-using-flow-cytometry
#2
Muhammed Majeed, Shaheen Majeed, Kalyanam Nagabhushanam, Ardra Punnapuzha, Sheena Philip, Lakshmi Mundkur
Accurate enumeration of bacterial count in probiotic formulation is imperative to ensure that the product adheres to regulatory standards and citation in consumer product label. Standard methods like plate count, can enumerate only replicating bacterial population under selected culture conditions. Viable but non culturable bacteria (VBNC) retain characteristics of living cells and can regain cultivability by a process known as resuscitation. This is a protective mechanism adapted by bacteria to evade stressful environmental conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29474268/twenty-five-years-of-lamivudine-current-and-future-use-for-the-treatment-of-hiv-1-infection
#3
Romina Quercia, Carlo-Federico Perno, Justin Koteff, Katy Moore, Cynthia McCoig, Marty St Clair, Daniel Kuritzkes
Innovation in medicine is a dynamic, complex, and continuous process that cannot be isolated to a single moment in time. Anniversaries offer opportunities to commemorate crucial discoveries of modern medicine, such as penicillin (1928), polio vaccination (inactivated, 1955; oral, 1961), the surface antigen of the hepatitis B virus (1967), monoclonal antibodies (1975), and the first HIV antiretroviral drugs (zidovudine, 1987). The advent of antiretroviral drugs has had a profound effect on the progress of the epidemiology of HIV infection, transforming a terminal, irreversible disease that caused a global health crisis into a treatable but chronic disease...
February 22, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29474153/consumers-use-of-personal-electronic-devices-in-the-kitchen
#4
Amy M Lando, Michael C Bazaco, Yi Chen
Smartphones, tablets, and other personal electronic devices have become ubiquitous in Americans' daily lives. These devices are used by people throughout the day, including while preparing food. For example, a device may be used to look at recipes and therefore be touched multiple times during food preparation. Previous research has indicated that cell phones can harbor bacteria, including opportunistic human pathogens such as Staphylococcus and Klebsiella spp. This investigation was conducted with data from the 2016 Food Safety Survey (FSS) and from subsequent focus groups to determine the frequency with which consumers use personal electronic devices in the kitchen while preparing food, the types of devices used, and hand washing behaviors after handling these devices...
February 23, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29473362/-effects-of-electroacupuncture-on-expression-of-cd36-in-peritoneal-macrophages-of-rabbits-with-atherosclerosis
#5
Zedong Cheng, Yulou Ning, Rui Wang
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expressions of CD36 gene and protein in peritoneal macrophages of atherosclerotic rabbits, and to explore the mechanism of acupuncture regulation of atherosclerosis. METHODS: A total of 26 male New Zealand rabbits were randomly divided into a blank group (7 rabbits) and a model group (19 rabbits). The rabbits in the blank group were fed with common feedstuff, and those in the model group were applied with high fat diet and arteria carotis communis bullon injury...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29472752/low-dose-mirtazapine-induced-nightmares-necessitating-its-discontinuation-in-a-young-adult-female
#6
Vikas Menon, Pravallika Madhavapuri
Mirtazapine is a novel tetracyclic antidepressant which enhances noradrenergic and serotonergic transmission by blocking central α2-adrenergic auto- and hetero-receptors. Due to favorable safety and adverse effect profile, it is often viewed as a promising agent for treatment of depression. Particularly, its anxiolytic and sleep-improving properties have led to its favorable positioning for the management of depression with insomnia. Our objective is to describe a case of depression with treatment-emergent nightmares induced by mirtazapine...
October 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29472748/efficacy-and-safety-of-oral-diclofenac-sustained-release-versus-transdermal-diclofenac-patch-in-chronic-musculoskeletal-pain-a-randomized-open-label-trial
#7
Viraj Ashok Shinde, Mrunalini Kalikar, Satyajeet Jagtap, Ganesh N Dakhale, Mangesh Bankar, Chaitali S Bajait, Vijay M Motghare, Ashlesha A Pashilkar, Latesh B Raghute, Ajita D Khamkar
Introduction: To compare the efficacy, safety, and tolerability of transdermal patches of diclofenac sodium with oral diclofenac sustained release (SR) in patients of chronic musculoskeletal MSK pain conditions. Materials and Methods: The eligible patients were given either transdermal diclofenac patch or tablet diclofenac SR. Pain was assessed at 2 and 4 weeks using a visual analog scale. Adverse events were recorded. Patients with 18-65 years old of either gender with score of ≥4 on a 11-item numeric rating scale-numeric version of visual analog scale for pain with diagnosis of primary osteoarthritis (OA) of the knee or hand of at least 3 months duration, with independent radiological confirmation of OA or having pain associated with other MSK conditions such as soft-tissue rheumatism, cervical and lumbar back pain, and fibromyalgia, of at least 3 months duration were included in this study...
October 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29472513/stability-of-an-extemporaneously-compounded-minoxidil-oral-suspension
#8
Yunmei Song, Zen Whey Chin, David Ellis, Ei Mon Phyo Lwin, Sean Turner, Desmond Williams, Sanjay Garg
PURPOSE: Results of a study to determine the stability of an extemporaneously compounded minoxidil oral suspension under various temperature and stress conditions are reported. METHODS: Commercially available minoxidil tablets (10 mg) were crushed to a fine powder, and predetermined amounts of 2 suspending vehicles were added to produce a 1-mg/mL suspension, which was stored in glass bottles at room temperature (25 ± 2 °C) or in a refrigerator (4 ± 2 °C). To simulate daily patient use, 5 days weekly 1 bottle of the suspension was removed from refrigerated storage and shaken and 0...
March 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29471832/accuracy-and-impact-of-spatial-aids-based-upon-satellite-enumeration-to-improve-indoor-residual-spraying-spatial-coverage
#9
Daniel J Bridges, Derek Pollard, Anna M Winters, Benjamin Winters, Chadwick Sikaala, Silvia Renn, David A Larsen
BACKGROUND: Indoor residual spraying (IRS) is a key tool in the fight to control, eliminate and ultimately eradicate malaria. IRS protection is based on a communal effect such that an individual's protection primarily relies on the community-level coverage of IRS with limited protection being provided by household-level coverage. To ensure a communal effect is achieved through IRS, achieving high and uniform community-level coverage should be the ultimate priority of an IRS campaign. Ensuring high community-level coverage of IRS in malaria-endemic areas is challenging given the lack of information available about both the location and number of households needing IRS in any given area...
February 23, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29469600/development-and-standardization-of-moringa-oleifera-leaves-as-a-natural-dietary-supplement
#10
Muhammad Azhar Ali, Yus Aniza Yusof, Nyuk Ling Chin, M N Ibrahim, Sadaf Muneer
Moringa oleifera leaves were selected as a model due to their hundreds of health benefits. On the other hand, the powder of these leaves has exhibited poor flowability, low tensile strength, bitter taste, poor dissolution rate, and lack of information regarding dosage. These are the common hurdles and limitations in the adaptation of herbal-based medications. Therefore, a comprehensive study was planned to introduce herbal-based medicines into mainstream medicines by standardization according to the U.S. Food and Drug Administration (FDA) and international pharmaceutical standards...
February 22, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29469240/actual-versus-expected-doses-of-half-tablets-containing-prescribed-psychoactive-substances-a-systematic-review
#11
Jaqueline K Eserian, Márcia Lombardo, Jair R Chagas, José C F Galduróz
Objective: To assess through a systematic review of the literature if the practice of splitting tablets containing psychoactive/psychotropic medications for medical or economic reasons would result in the expected doses. Data Sources: A MEDLINE and PsycInfo comprehensive search of English-language publications from January 1999 to December 2015 was conducted using the terms describing tablet splitting (tablet splitting, split tablets, tablet subdivision, divided tablets, and half tablets) and psychoactive substances (psychoactive medicines, psychotropic medicines, antidepressants, anxiolytics, anticonvulsants, antipsychotics, and antiparkinsonian agents)...
February 8, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29468978/comparing-effectiveness-of-a-combined-herbal-drug-based-on-echium-amoenum-with-citalopram-in-the-treatment-of-major-depressive-disorder
#12
Majid Anushiravani, Ali Akhondpour Manteghi, Ali Taghipur, Mahdi Eslami
BACKGROUND: According to new studies, only 60% of depressed patients respond to pharmaceutical treatment while suffering from their side effects. Natural products as adjuvant or alternative therapies should be examined to find safer and more effective ways to cope with depression. OBJECTIVE: Finding out the potential benefits of a combined herbal drug based on Echium amoenum compared with citalopram in the treatment of Major Depressive Disorder. DESIGN AND SETTING: In psychiatry clinics of Mashhad University of Medical Sciences, 50 patients who met the criteria for Major Depressive Disorder based on DSM-5 were studied in a parallel randomized controlled trial...
February 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29467656/sublingual-administration-of-sildenafil-oro-dispersible-film-new-profiles-of-drug-tolerability-and-pharmacokinetics-for-pde5-inhibitors
#13
Luca De Toni, Maurizio De Rocco Ponce, Erica Franceschinis, Stefano Dall'Acqua, Roberto Padrini, Nicola Realdon, Andrea Garolla, Carlo Foresta
Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetics associated to the sublingual administration of the new available oro-dispersible film (ODF), compared to both the oro-dispersible tablet (ODT) and the film-coated tablet (FCT) as original per os formulation. Methods: In vitro disaggregation test, dissolution test, and permeation test in specific devices to estimate the trans-mucosal absorption...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29467529/editorial-assessing-esophageal-function-in-achalasia-the-old-and-the-new
#14
Joseph R Triggs, Peter J Kahrilas
Achalasia is currently diagnosed according to the Chicago Classification v3.0 using high-resolution manometry and treatment focuses on disruption of the esophagogastric junction. A paper in this issue examines the utility of a timed barium esophagram with a 13 mm tablet challenge in differentiating achalasia from other diagnoses, finding 100% sensitivity. However, a large proportion of patients with non-achalasia dysphagia are also identified. Another paper in this issue proposes utilizing intraprocedure functional luminal imaging probe measurement during pneumatic dilation as a guide for upsizing dilations...
February 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29465298/the-determination-of-the-validity-of-an-application-based-knee-training-device
#15
Hauke Horstmann, Eva Krost, Bastian Welke, Arno Kerling, Alexander Hanke, Eike Jakubowitz, Thomas Sanjay Weber-Spickschen
The goals of knee rehabilitation are to improve range of motion and muscle status. The aim of the study was to investigate accuracy and reproducibility of a newly designed knee-training device (KT) under standardized laboratory conditions. Two application-based software programs, one to measure maximum force and one intended to improve users' coordination were developed to be used on a tablet during exercises wireless connected to KT placed under the popliteal fossa. KT was loaded for twenty intervals of 15 seconds (s) ranging between 0-350 Newton (N) each...
February 21, 2018: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29464917/head-to-head-comparison-of-the-heart-rate-variability-between-the-bisoprolol-transdermal-patch-and-bisoprolol-fumarate-tablet
#16
Akinori Sairaku, Yukiko Nakano, Nobuo Shiode, Kazuyoshi Suenari, Nozomu Oda, Koichi Ono, Yasuki Kihara
AIM: The bisoprolol transdermal patch is a newly developed β-blocker designed to deliver its pharmaceutical ingredient through the skin surface. We aimed to compare the bisoprolol transdermal patch and bisoprolol fumarate tablet using the heart rate variability (HRV). METHOD: Eligible hypertensive patients received a 2-week administration with a 2.5 mg bisoprolol fumarate tablet, followed by 24-hour Holter monitoring. The tablet was then switched to a 4 mg bisoprolol transdermal patch, and after 2-weeks of its administration, the Holter monitoring was repeated...
February 21, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29464233/understanding-the-decision-to-commence-a-dose-administration-aid
#17
Elsa Barton, Lydia Twining, Lucie Walters
BACKGROUND: The use of dose administration aids (DAAs), such as compartmentalised boxes (eg dosette) or medicine packs (eg Webster-pak), is common, particularly among patients with chronic disease. The aim of this study was to investigate factors influencing patients' decisions to commence using a DAA with a view to summarising implications for practice for general practitioners (GPs). METHODS: Semi-structured interviews were undertaken with participants living in a regional town in South Australia...
December 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29463874/prominent-exostosis-projecting-from-the-occipital-squama-more-substantial-and-prevalent-in-young-adult-than-older-age-groups
#18
David Shahar, Mark G L Sayers
Recently we reported the development of prominent exostosis young adults' skulls (41%; 10-31 mm) emanating from the external occipital protuberance (EOP). These findings contrast existing reports that large enthesophytes are not seen in young adults. Here we show that a combination sex, the degree of forward head protraction (FHP) and age predicted the presence of enlarged EOP (EEOP) (n = 1200, age 18-86). While being a male and increased FHP had a positive effect on prominent exostosis, paradoxically, increase in age was linked to a decrease in enthesophyte size...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462633/improved-stability-of-tb-drug-fixed-dose-combination-using-isoniazid-caffeic-acid-and-vanillic-acid-cocrystal
#19
Battini Swapna, M K Chaitanya Mannava, Ashwini Nangia
The classic FDC of four TB drugs, namely Rifampicin (RIF), Isoniazid (INH), Pyrazinamide (PZA) and Ethambutol Dihydrochloride (EDH) has the twin issues of physical stability and rifampicin cross-reaction in the 4FDC. The major reason for these quality issues is the interaction between RIF and INH to yield isonicotinyl hydrazone (HYD) in drug tablets. Pharmaceutical cocrystals of INH with caffeic acid (PZA + EDH + RIF + INH-CFA cocrystal) and vanillic acid (PZA + EDH + RIF + INH-VLA cocrystal) are able to stabilize the FDC formulation compared to the reference batch (PZA + EDH + RIF + INH)...
February 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29462506/evaluation-of-flexible-tacrolimus-drug-concentration-monitoring-approach-in-patients-receiving-extended-release-once-daily-tacrolimus-tablets
#20
Benjamin Philosophe, Nicolae Leca, Patricia M West-Thielke, Timothy Horwedel, Christine Culkin-Gemmell, Kristin Kistler, Daniel R Stevens
The majority of United States kidney transplant patients are treated with tacrolimus, a drug effective in preventing graft rejection, but with a narrow therapeutic range, necessitating close monitoring to avoid increased risks of transplant rejection or toxicity if the tacrolimus concentration is too low or too high, respectively. The trough drug concentration tests are time sensitive; patients treated on a twice-daily basis have blood draws exactly 12 hours after their previous dose. The schedule's rigidity causes problems for both patients and health care providers...
February 20, 2018: Journal of Clinical Pharmacology
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