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José Carlos Marín-Gabriel, José Díaz-Tasende, Sarbelio Rodríguez-Muñoz, Andrés Del Pozo-García, Carolina Ibarrola-Andrés
The endoscopic treatment of early gastrointestinal neoplasms usually involves the resection of the superficial layers, mucosa and submucosa, of the wall. However, in some circumstances, a full-thickness resection may be necessary. Endoscopic full-thickness resection (EFTR) may be an adequate approach in challenging lesions such as adenomas or early cancers with severe submucosal fibrosis or small sub-epithelial lesions in the lower GI tract. Furthermore, this novel technique has the potential to spare surgical therapy in a subset of cases...
January 23, 2017: Revista Española de Enfermedades Digestivas
H-J Richter-Schrag, C Walker, R Thimme, A Fischer
BACKGROUND: The diagnostic validity of a full-thickness resection is higher compared to endoscopic mucosal resection (EMR) or endoscopic mucosal dissection (ESD). Whereas transanal endoscopic microsurgery techniques (TEM, TAMIS) are established therapeutic procedures in the rectum no established and safe minimally invasive or endoscopic procedure exists in the colon. AIM: In this study the novel endoscopic full thickness resection device (FTRD, Ovesco, Germany) was investigated concerning success rates with histologically proven full thickness resections, R0 status as well as patient and device safety for the rectum and colon...
April 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Arthur Schmidt, Benjamin Meier, Oscar Cahyadi, Karel Caca
BACKGROUND AND AIMS: Endoscopic resection of duodenal non-lifting adenomas and subepithelial tumors is challenging and harbors a significant risk of adverse events. We report on a novel technique for duodenal endoscopic full-thickness resection (EFTR) by using an over-the-scope device. METHODS: Data of 4 consecutive patients who underwent duodenal EFTR were analyzed retrospectively. Main outcome measures were technical success, R0 resection, histologic confirmation of full-thickness resection, and adverse events...
October 2015: Gastrointestinal Endoscopy
Arthur Schmidt, Peter Bauerfeind, Christoph Gubler, Michael Damm, Markus Bauder, Karel Caca
BACKGROUND AND STUDY AIMS: Endoscopic full-thickness resection (EFTR) in the lower gastrointestinal tract may be a valuable therapeutic and diagnostic approach for a variety of indications. Although feasibility of EFTR has been demonstrated, there is a lack of safe and effective endoscopic devices for routine use. The aim of this study was to investigate the efficacy and safety of a novel over-the-scope device for colorectal EFTR. PATIENTS AND METHODS: Between July 2012 and July 2014, 25 patients underwent EFTR at two tertiary referral centers...
August 2015: Endoscopy
Marc O Schurr, Franziska E Baur, Martina Krautwald, Marion Fehlker, Manfred Wehrmann, Thomas Gottwald, Ruediger L Prosst
BACKGROUND: The benefit of endoscopic full-thickness resection is the improved diagnostic work-up with an integral wall specimen which allows a precise determination of the tumor or its precursor and its infiltration depth into the wall. MATERIALS AND METHODS: A new endoscopic full-thickness resection device (FTRD), which is a combination of a modified over-the-scope-clip (OTSC) system with an electrocautery snare, has been tested in an experimental setting. In eleven pigs, divided into three groups, endoscopic full-thickness resection was performed in the colon at one or two sites, respectively...
August 2015: Surgical Endoscopy
Shun Watanabe, Michiya Hanyu, Yoshio Arai, Atsushi Nagasawa
BACKGROUND: There are contradictory reports on outcomes of patients treated for Stanford type A acute intramural hematoma (IMH) and acute aortic dissections (AAD) with thrombosed false lumens. We evaluated short-term clinical outcomes and predictors of adverse outcomes. METHODS: We retrospectively analyzed 59 symptomatic patients with type A acute IMH and AAD with thrombosed thoracic false lumens who initially received treatment. Survival, aortic death (death from aortic events and sudden deaths), and aortic event-free survival rates were investigated...
December 2013: Annals of Thoracic Surgery
Andrea Garavito, Romain Guyot, Jaime Lozano, Frédérick Gavory, Sylvie Samain, Olivier Panaud, Joe Tohme, Alain Ghesquière, Mathias Lorieux
S(1) is the most important locus acting as a reproductive barrier between Oryza sativa and O. glaberrima. It is a complex locus, with factors that may affect male and female fertility separately. Recently, the component causing the allelic elimination of pollen was fine mapped. However, the position and nature of the component causing female sterility remains unknown. To fine map the factor of the S(1) locus affecting female fertility, we developed a mapping approach based on the evaluation of the degree of female transmission ratio distortion (fTRD) of markers...
August 2010: Genetics
Yohei Koide, Kazumitsu Onishi, Daisuke Nishimoto, Akhil Ranjan Baruah, Akira Kanazawa, Yoshio Sano
* A sex-independent transmission ratio distortion (siTRD) system detected in the interspecific cross in rice was analyzed in order to understand its significance in reproductive barriers. The S(1) gene, derived from African rice Oryza glaberrima, induced preferential abortion of both male and female gametes possessing its allelic alternative (), from Asian rice O. sativa, only in the heterozygote. * The siTRD was characterized by resolving it into mTRD and fTRD occurring through male and female gametes, respectively, cytological analysis of gametophyte development, and mapping of the S(1) locus using near-isogenic lines...
2008: New Phytologist
(no author information available yet)
We describe a novel device for full thickness resectioning of large bowel lesions. The device has been assessed in experimental studies. Tumours of the large bowel are a frequent disease with increasing incidence figures. If detected at an early stage, local treatment of colon tumours is possible through an endoluminal access. Currently, full thickness resection can only be performed in the rectum with the TEM technique, while snare resection through the flexible endoscope will only allow mucosa resection. We have developed a new device which allows full thickness bowel wall resections up to the splenic flexure...
November 2001: Minimally Invasive Therapy & Allied Technologies: MITAT
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