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https://www.readbyqxmd.com/read/29349870/drug-dosing-in-pregnant-women-challenges-and-opportunities-in-using-physiologically-based-pharmacokinetic-modeling-and-simulations
#1
REVIEW
Alice Ban Ke, Rick Greupink, Khaled Abduljalil
No abstract text is available yet for this article.
January 19, 2018: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29332841/improved-neuron-culture-using-scaffolds-made-of-three-dimensional-pdms-micro-lattices
#2
Sisi Li, Francesco Paolo Ulloa Severino, Jelena Ban, Li Wang, Giulietta Pinato, Vincent Torre, Yong Chen
Tissue engineering strives to create functional components of organs with different cell types in vitro. One of the challenges is to fabricate scaffolds for three-dimensional (3D) cell culture under physiological conditions. Of particular interesting is to investigate the morphology and function of the central nervous system (CNS) cultured using such scaffolds. Here, we used an elastomer, polydimethylsiloxane (PDMS), to produce lattice-type scaffolds from a photolithography defined template. The photomask with antidot arrays was spin-coated by a thick layer of resist and downward mounted on a rotating stage at angle of 45°...
January 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29319718/effects-of-periarticular-injection-on-analgesic-effects-and-nsaid-use-in-total-knee-arthroplasty-and-total-hip-arthroplasty
#3
Wen-Rui Ban, Ery-Ang Zhang, Lei-Feng Lv, Xiao-Qian Dang, Chen Zhang
OBJECTIVES: This study examined periarticular multimodal drug injection and the use of nonsteroidal anti-inflammatory drugs for an early analgesic effect after total knee arthroplasty and total hip arthroplasty. Patient satisfaction and benefits from the treatment were also assessed. METHODS: A total of 110 patients who were scheduled to undergo total knee arthroplasty and 86 patients who were scheduled to undergo total hip arthroplasty were divided into two groups, the study group and the control group...
December 2017: Clinics
https://www.readbyqxmd.com/read/29313696/spontaneous-hepatic-rupture-in-a-bodybuilder-a-case-report-and-review-of-the-literature
#4
Pietro Mascagni, Fabio Melandro, Zoe Larghi Laureiro, Gianluca Mennini, Massimo Rossi
This article is the first description of a spontaneous hepatic rupture in a young bodybuilder with a history of clenbuterol and ephedrine alkaloid use. The patient presented with a sudden mid-epigastric pain and vomiting. Hemoglobin levels decreased a few hours later and a computed tomography scan was performed which revealed a rupture of the right liver capsule and hemoperitoneum. Two attempts at transarterial embolization did not control the bleeding and a right hemihepatectomy was performed. The pathological report identified a hepatic adenoma, a capsular tear and diffuse peliosis hepatis...
January 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29296031/dextromethorphan-in-cough-syrup-the-poor-man-s-psychosis
#5
Bridgette Martinak, Ramy A Bolis, Jeffrey Ryne Black, Rachel E Fargason, Badari Birur
Dextromethorphan (3-methoxy-N-methylmorphinan), also known as "DXM" and "the poor man's PCP," is a synthetically produced drug that is available in more than 140 over-the-counter cough and cold preparations. Dextromethorphan (DXM) has overtaken codeine as the most widely used cough suppressant due to its availability, efficacy, and safety profile at directed doses. However, DXM is subject to abuse. When consumed at inappropriately high doses (over 1500 mg/day), DXM can induce a state of psychosis characterized by Phencyclidine (PCP)-like psychological symptoms, including delusions, hallucinations, and paranoia...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#6
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29284458/menthol-cigarettes-and-the-public-health-standard-a-systematic-review
#7
Andrea C Villanti, Lauren K Collins, Raymond S Niaura, Stacey Y Gagosian, David B Abrams
BACKGROUND: Although menthol was not banned under the Tobacco Control Act, the law made it clear that this did not prevent the Food and Drug Administration from issuing a product standard to ban menthol to protect public health. The purpose of this review was to update the evidence synthesis regarding the role of menthol in initiation, dependence and cessation. METHODS: A systematic review of the peer-reviewed literature on menthol cigarettes via a PubMed search through May 9, 2017...
December 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29283576/accurate-quantitation-and-analysis-of-nitrofuran-metabolites-chloramphenicol-and-florfenicol-in-seafood-by-uhplc-ms-ms-method-validation-and-regulatory-samples
#8
Fadi Aldeek, Kevin Hsieh, Obiadada Ugochukwu, Ghislain Gerard, Walter Hammack
We developed and validated a method for the extraction, identification, and quantitation of four nitrofuran metabolites: (3-amino-2-oxazolidinone (AOZ); 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ); semicarbazide (SC); and 1-aminohydantoin (AHD)), as well as chloramphenicol and florfenicol, in a variety of seafood commodities. Samples were extracted by liquid-liquid extraction techniques, analyzed by UHPLC-MS/MS, and quantitated using commercially sourced, derivatized nitrofuran metabolites, with their isotopically-labelled internal standards in-solvent...
December 28, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29279007/the-effect-of-diet-enriched-with-rapeseed-meal-on-endogenous-thiouracil-contents-in-urine-and-milk-of-cattle
#9
Barbara Wozniak, Iwona Matraszek-Zuchowska, Sebastian Witek, Jan Zmudzki, Andrzej Posyniak
Thyreostatic compounds, such as thiouracil (TU) are orally active drugs that can be used to increase the weight of cattle before slaughter. Due to potentially teratogenic and carcinogenic effects of their residues on public health, the use of thyreostats in animal production has been banned in the European Union since 1981. Systematic detection of low concentrations of thiouracil in the urine of livestock in many countries is believed to be of endogenous origin due to the use of Brassicaceae plants in the animal diet...
December 26, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29277689/aerosol-delivery-during-spontaneous-breathing-with-different-types-of-nebulizers-in-vitro-ex-vivo-models-evaluation
#10
Hui-Ling Lin, Tien-Pei Fang, Hui-Sun Cho, Gwo-Hwa Wan, Meng-Jer Hsieh, James B Fink
BACKGROUND: Nebulizers for spontaneous breathing have been evaluated through different study designs. There are limitations in simulated bench models related to patient and nebulizer factors. The aim of this study was to determine the correlation of inhaled drug mass between in vitro and ex vivo studies by testing aerosol deposition of various types of nebulizers. METHODS: Ten healthy subjects were recruited to receive aerosol therapy with five nebulizers in random order: 1) a jet nebulizer (JN); 2) a breath-enhanced nebulizer (BEN); 3) a manually triggered nebulizer (MTN), 4) a breath-actuated nebulizer (BAN), and 5) a vibrating mesh nebulizer (VMN) with valved-adapter...
December 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29273821/the-abuse-potential-of-kratom-according-the-8-factors-of-the-controlled-substances-act-implications-for-regulation-and-research
#11
REVIEW
Jack E Henningfield, Reginald V Fant, Daniel W Wang
RATIONALE: Consideration by the US Drug Enforcement Administration and Food and Drug Administration of placing kratom into Schedule I of the Controlled Substances Act (CSA) requires its evaluation of abuse potential in the context of public health. OBJECTIVE: The objective of the study is to provide a review of kratom abuse potential and its evaluation according to the 8 factors of the CSA. RESULTS: Kratom leaves and extracts have been used for centuries in Southeast Asia and elsewhere to manage pain and other disorders and, by mid-twentieth century, to manage opioid withdrawal...
December 23, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29247699/fast-and-non-destructive-pore-structure-analysis-using-terahertz-time-domain-spectroscopy
#12
Daniel Markl, Prince Bawuah, Cathy Ridgway, Sander van den Ban, Daniel J Goodwin, Jarkko Ketolainen, Patrick Gane, Kai-Erik Peiponen, J Axel Zeitler
Pharmaceutical tablets are typically manufactured by the uni-axial compaction of powder that is confined radially by a rigid die. The directional nature of the compaction process yields not only anisotropic mechanical properties (e.g. tensile strength) but also directional properties of the pore structure in the porous compact. This study derives a new quantitative parameter, Sa, to describe the anisotropy in pore structure of pharmaceutical tablets based on terahertz time-domain spectroscopy measurements. The Sa parameter analysis was applied to three different data sets including tablets with only one excipient (functionalised calcium carbonate), samples with one excipient (microcrystalline cellulose) and one drug (indomethacin), and a complex formulation (granulated product comprising several excipients and one drug)...
December 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29246208/when-it-just-won-t-go-away-oral-artemisinin-monotherapy-in-nigeria-threatening-lives-threatening-progress
#13
Chinazo Ujuju, Jennifer Anyanti, Paul N Newton, Godwin Ntadom
BACKGROUND: Oral artemisinin monotherapy (AMT), an important contributor to multi-drug resistant malaria, has been banned in Nigeria. While oral AMT has scarcely been found for several years now in other malaria-endemic countries, availability has persisted in Nigeria's private sector. In 2015, the ACTwatch project conducted a nationally representative outlet survey. Results from the outlet survey show the extent to which oral AMT prevails in Nigeria's anti-malarial market, and provide key product information to guide strategies for removal...
December 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29207575/synthesis-of-novel-nitrogen-containing-heterocycle-bromophenols-and-their-interaction-with-keap1-protein-by-molecular-docking
#14
Xiu E Feng, Qin Jin Wang, Jie Gao, Shu Rong Ban, Qing Shan Li
We previously reported 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanoe (LM49), a bromophenol analogue that shows strong protection from oxidative stress injury owing to its superior anti-inflammatory, antioxidant, and anti-apoptotic properties. A series of novel nitrogen-containing heterocycle bromophenols were herein synthesized by introducing substituted piperidine, piperazine, and imidazole to modify 2-position of the lead compound LM49. By further evaluating their cytoprotective activity against H₂O₂ induced injury in EA...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29204127/synthetic-aminoindanes-a-summary-of-existing-knowledge
#15
REVIEW
Nikola Pinterova, Rachel R Horsley, Tomas Palenicek
Objectives: Aminoindanes ("bath salts," a class of novel psychoactive substances, NPSs) increased rapidly in popularity on the recreational drug market, particularly after mephedrone and other synthetic cathinones were banned in the UK in 2010. Novel aminoindanes continue to emerge, but relatively little is known about their effects and risks. Their history, chemistry, pharmacology, behavioral effects, pharmacokinetics, and toxicity are reviewed in this paper. Methods: Scientific literature was searched on ISI Web of Knowledge: Web of Science (WoS) during June and July 2017, using English language terms: aminoindanes such as 5,6-methylenedioxy-2-aminoindane (MDAI), 5-iodo-2-aminoindane (5-IAI), 2-aminoindane (2-AI), 5,6-methylenedioxy-N-methyl-2-aminoindane (MDMAI), and 5-methoxy-6-methyl-2-aminoindane (MMAI)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29203462/ban-evergreening-and-restricting-generics-to-reduce-drug-prices-says-us-academy
#16
Bob Roehr
No abstract text is available yet for this article.
December 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29203214/unravelling-the-differences-comparative-proteomic-analysis-of-a-clonal-virulent-and-an-attenuated-histomonas-meleagridis-strain
#17
Andreas Monoyios, Martina Patzl, Sarah Schlosser, Michael Hess, Ivana Bilic
The current study focused on Histomonas meleagridis, a unicellular protozoan, responsible for histomonosis in poultry. Recently, the occurrence of the disease increased due to the ban of effective chemotherapeutic drugs. Basic questions regarding the molecular biology, virulence mechanisms or even life cycle of the flagellate are still puzzling. In order to address some of these issues, we conducted a comparative proteomic analysis of a virulent and an attenuated H. meleagridis strain traced back to a single cell and propagated in vitro as monoxenic mono-eukaryotic cultures...
December 1, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/29182464/triclosan-exposure-transformation-and-human-health-effects
#18
REVIEW
Lisa M Weatherly, Julie A Gosse
Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the US Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. TCS is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29181881/effects-of-triclosan-on-japanese-medaka-oryzias-latipes-during-embryo-development-early-life-stage-and-reproduction
#19
Yoshifumi Horie, Takahiro Yamagishi, Hiroko Takahashi, Taisen Iguchi, Norihisa Tatarazako
Triclosan has been shown to have endocrine-disrupting effects in aquatic organisms. In 2016, the US Food and Drug Administration banned the use of triclosan in consumer soaps. Before the ban, triclosan was reported at low concentrations in the aquatic environment, although the effect of triclosan on reproduction in teleost fish species is yet to be clarified. Here we investigated the effects of triclosan on embryo development and reproduction, and during the early life stage, in Japanese medaka (Oryzias latipes) by using Organisation for Economic Co-operation and Development tests 229, 212 and 210, with minor modifications...
November 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29164917/efficacy-and-safety-of-palbociclib-in-heavily-pretreated-patients-with-hr-her2-%C3%A2-metastatic-breast-cancer
#20
Marija Ban, Branka Petrić Miše, Ana Majić, Ivanka Dražić, Eduard Vrdoljak
AIM: CDK4/6 inhibitors in the first and second treatment line in patients with HR+/HER2- metastatic breast cancer (mBC) in combination with hormonal therapy improve progression free survival. Role of CDK4/6 inhibitors in further treatment lines remains unclear. METHODS: Retrospective analysis of 24 HR+/HER2- heavily pretreated mBC patients is presented. RESULTS: A total of 58.3% patients achieved stable disease. No objective response was observed...
November 22, 2017: Future Oncology
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