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banned drugs

Xuan Zhang, Yi-Chi Zhang, Jia-Wei Zhang
Chloramphenicol (CAP), as a broad-spectrum antibiotic, has been worldwide banned for using in the food producing animals due to its overuse may cause severe threats to public health. It is therefore highly desirable to develop facile, selective and sensitive biosensor for CAP detection and monitoring in drug and foodstuff samples. In this work, three-dimensional reduced graphene oxide (3DRGO) architectures were prepared through a green and template-free approach and used as active electrode materials to develop a highly selective electrochemical sensor for CAP detection...
December 1, 2016: Talanta
Patrick J McNamara, Stuart B Levy
The Food and Drug Administration (FDA) recently released a final rule to ban triclosan and 18 other antimicrobial chemicals from soaps. We applaud this rule specifically because of the associated risks that triclosan poses to the spread of antibiotic resistance throughout the environment. This persistent chemical will apply constant stress to bacteria to adapt, and behavior that promotes antibiotic resistance needs to be stopped immediately when the benefits are null.
October 10, 2016: Antimicrobial Agents and Chemotherapy
Jadwiga Nędza, Renata Polaniak, Rafał J Bułdak, Milena Majchrzak, Joanna Margasiń-Ska, Marcin Rojkiewicz, Rafał Celiński, Elżbieta Grochowska-Niedworok
Recently, there has been an increase in the consumption of designer drugs, substances aimed at producing psychoactive, energizing, euphoric or anesthetic effects. Designer drugs are substitutes of actual narcotics, whose possession is banned under Polish law according to the Act of 29 July 2005. The latest reports suggest that the number of synthetic psychoactive substances is increasing. In the span of 2012, a total of 28 new synthetic cannabinoids were discovered in member states of the European Union. Synthetic psychoactive substances appear in different forms on the market: tablets (often very colourful and interestingly-shaped), seeds, dried product (sprayed with synthetic substance and redried), crystals or powder...
July 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Zhibin Wu, Fei Ling, Chenguang Song, Weichao Chen, Gaoxue Wang
Since the use of malachite green was banned, it is desirable to search for alternative drug to control Ichthyophthirius multifiliis infection. Moreover, route of administration which is easy to implement and less stressful to fish is important to treat infection of fish with this parasite. It is also important to enhance protective effect against Aeromonas hydrophila infection after parasitism by I. multifiliis. The present study evaluated the protective effect of diet supplemented with Artemisia annua against I...
October 10, 2016: Parasitology Research
Andriy Stelmakh, Orest Abrahamovych, Andriy Cherkas
Highly purified calf hemodialysate (HPCH) known as Actovegin® or Solcoseryl® is one of the most controversial drugs currently marketed worldwide. It is not registered as drug in some countries and therefore its medical use there is illegal, while in others it is often among the top 10 of the best-selling medications. It could be also found in the list of the "most useless drugs" and was banned for short time by World Anti-Doping Agency as performance enhancer. However, the degree of its usefulness or uselessness remains unclear and there is not enough convincing data to make reliable conclusions...
October 2016: Medical Hypotheses
D Liebhart, P Ganas, T Sulejmanovic, M Hess
Histomonosis is a parasitic disease of poultry with worldwide prevalence. The disease can cause morbidity and mortality in chicken and turkey flocks entailing severe economic losses. In the first half of the last century there was a high demand to control histomonosis as the turkey industry was severely affected by the disease. Consequently, numerous chemical compounds were tested for their efficacy against H. meleagridis with varying outcomes, altogether summarized and specified in this review. At the same time, preliminary attempts to protect birds with cultured histomonads indicated the possibility of vaccination...
September 13, 2016: Avian Pathology: Journal of the W.V.P.A
Václav Bazgier, Karel Berka, Michal Otyepka, Pavel Banáš
Molecular docking is a powerful tool for theoretical prediction of the preferred conformation and orientation of small molecules within protein active sites. The obtained poses can be used for estimation of binding energies, which indicate the inhibition effect of designed inhibitors, and therefore might be used for in silico drug design. However, the evaluation of ligand binding affinity critically depends on successful prediction of the native binding mode. Contemporary docking methods are often based on scoring functions derived from molecular mechanical potentials...
October 30, 2016: Journal of Computational Chemistry
Geng-Ruei Chang, Hui-Shan Chen, Feng-Yi Lin
Seafood safety is a crucial public health concern for consumers. In this study, we applied a validated method to analyze the residue of banned veterinary drugs in shellfish, namely chloramphenicol, malachite green, leucomalachite green, and nitrofuran metabolites; additionally, the QuEChERS method was employed to detect 76 herbicides by LC/MS/MS and GC/MS/MS. In total, 42 shellfish samples, which included hard clams, freshwater clams, and oysters, were collected from aquafarms and production areas in Taiwan during 2012...
September 6, 2016: Marine Pollution Bulletin
Hans-Jörg Helmlin, André Mürner, Samuel Steiner, Matthias Kamber, Christina Weber, Hans Geyer, Sven Guddat, Wilhelm Schänzer, Mario Thevis
Hydrochlorothiazide (HCTZ, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide) belongs to the class of diuretic agents that represent one of today's cornerstones of the treatment of hypertensive patients. In addition to its clinical relevance, HCTZ is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA) at all times and has frequently been detected in sports drug testing urine samples worldwide since its ban was introduced in 1988. Despite these facts, the adverse analytical finding concerning HCTZ in an in-competition routine doping control sample collected in December 2014 was further investigated, particularly motivated by the comparably low urinary concentration of the drug accounting for approximately 5ng/mL...
October 2016: Forensic Science International
S Vijayavenkataraman, W F Lu, J Y H Fuh
The skin is the largest organ of the body, having a complex multi-layered structure and guards the underlying muscles, bones, ligaments, and internal organs. It serves as the first line of defence to any external stimuli, hence it is the most vulnerable to injury and warrants the need for rapid and reliable regeneration methods. Tissue engineered skin substitutes help overcome the limitations of traditional skin treatment methods, in terms of technology, time, and cost. While there is commendable progress in the treating of superficial wounds and injuries with skin substitutes, treatment of full-thickness injuries, especially with third or fourth degree burns, still looks murkier...
2016: Biofabrication
María Carmen Lara-Castillo, Josep Maria Cornet-Masana, Amaia Etxabe, Antònia Banús-Mulet, Miguel Ángel Torrente, Meritxell Nomdedeu, Marina Díaz-Beyá, Jordi Esteve, Ruth M Risueño
BACKGROUND: Treatment for acute myeloid leukemia (AML) has not significantly changed in the last decades and new therapeutic approaches are needed to achieve prolonged survival rates. Leukemia stem cells (LSC) are responsible for the initiation and maintenance of AML due to their stem-cell properties. Differentiation therapies aim to abrogate the self-renewal capacity and diminish blast lifespan. METHODS: An in silico screening was designed to search for FDA-approved small molecules that potentially induce differentiation of AML cells...
2016: Journal of Translational Medicine
Priyanka Prabhu, Shital Suryavanshi, Sulabha Pathak, Aditya Patra, Shobhona Sharma, Vandana Patravale
Patients with cerebral malaria (CM) are unable to take oral medication due to impaired consciousness and vomiting thus necessitating parenteral therapy. Quinine, artemether, and artesunate which are currently used for parenteral malaria therapy have their own drawbacks. The World Health Organization (WHO) has now banned monotherapy and recommends artemisinin-based combination therapy for malaria treatment. However, presently there is no intravenous formulation available for combination therapy of malaria. Artemether-Lumefantrine (ARM-LFN) is a WHO approved combination for oral malaria therapy...
September 3, 2016: International Journal of Pharmaceutics
Setha Limsreng, Olivier Marcy, Sowath Ly, Vara Ouk, Hak Chanroeurn, Saem Thavary, Ban Boroath, Ana Canestri, Gérald Viretto, Jean-François Delfraissy, Olivier Ségéral
BACKGROUND: Lopinavir/ritonavir (LPV/r) is widely used in Cambodia with high efficacy but scarce data exist on long-term metabolic toxicity. METHODS: We carried out a cross-sectional and retrospective study evaluating metabolic disorders and cardiovascular risk in Cambodian patients on LPV/r-based antiretroviral therapy (ART) for > 1 year followed in Calmette Hospital, Phnom Penh. Data collected included cardiovascular risk factors, fasting blood lipids and glucose, and retrospective collection of bioclinical data...
2016: PloS One
Lara El Khoury, Nabil Zeineddine, Richard Felix, Mark Goldstein
Levamisole is an antihelminthic drug banned by the US Food and Drug Administration (FDA) in 2000 because of its dangerous side effects. Over the past few years, it has been identified as an adulterant in cocaine and reported to cause cutaneous vasculitis in cocaine users. The health burden of levamisole is serious since it is estimated that over 5 million Americans use cocaine and that 70% of the cocaine used in the USA contains levamisole. In this paper we report the case of a 23-year-old female cocaine user that presented with purpuric rash and skin necrosis, found to have positive c-ANCA and anti-proteinase 3 antibodies...
2016: Case Reports in Rheumatology
Ga-Young Ban, Seun-Joo Ahn, Hye-Soo Yoo, Hae-Sim Park, Young-Min Ye
An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Rα levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections...
August 2016: Immune Network
(no author information available yet)
A hall of residence in the US which has banned tobacco, alcohol and drugs has been oversubscribed by over two to one.
December 7, 1994: Nursing Standard
Ana Tomas, Zdenko Tomić, Boris Milijasević, Milica Ban, Olga Horvat, Sasa Vukmirović, Ana Sabo
BACKGROUND/AIM: Hypertension is one of the leading causes of cardiovascular morbidity and mortality and more than a half of all health insurance expenditures for reimbursed medicines are allocated to antihypertensive drugs in Serbia. The aim of this study was to identify the antihypertensive drug utilization patterns among hypertensive outpatients in the city of Novi Sad, Serbia, determine the adherence to clinical guidelines and address the economic aspects of current prescribing practices...
June 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Eunmi Ban, Dong-Jin Jang, Su-Jin Kim, Mijung Park, Aeri Kim
The objective of this study was to optimize thermoreversible gel formulations with respect to their gelation temperature and solubilizing capacity, using quality by design principles based on design of experiment (DoE). Independent variables, X1, X2, and X3, represent the weight percentages of Poloxamer 407, Poloxamer 188, and the polyethylene glycol 400, respectively (these polymers are either thermoreversible gelling agents or solubilizers). Emodin, a poorly water-soluble compound, was used as a model drug...
August 2, 2016: Pharmaceutical Development and Technology
Sara Eichner, Michelle Maguire, Leticia A Shea, Matthew G Fete
OBJECTIVES: To identify banned and discouraged-use ingredients, such as ephedra, 1,3-dimethylamylamine, and beta-methyl-phenylethylamine, in readily available weight loss dietary supplements within a 10-mile radius of Regis University. METHODS: A list of banned and discouraged-use ingredients was compiled with the use of the Food and Drug Administration (FDA) dietary supplement website which provides information on supplement ingredients that are no longer legal or are advised against owing to adverse event reporting...
September 2016: Journal of the American Pharmacists Association: JAPhA
Chaohua Tang, Xiaowei Liang, Kai Zhang, Qingyu Zhao, Qingshi Meng, Junmin Zhang
Ractopamine was approved by the US Food and Drug Administration for use as a growth promoter on cattle a decade ago is still banned by the European Union and most Asian countries. While, ractopamine residues in living samples and some organs (besides liver, muscle and kidney) of cattle under the recommended feed condition (10-30 mg/kg in dry matter, 28-42 days) remains unclear. In this study, nine cattle (246.22 ± 18.17 kg) were fed 0.67 mg/kg body weight (equivalent to 30 mg/kg in dry matter) of ractopamine for 28 days to investigate the residues of ractopamine in plasma, urine and organs...
July 29, 2016: Journal of Analytical Toxicology
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