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https://www.readbyqxmd.com/read/28107189/docosahexaenoic-acid-and-disulfiram-act-in-concert-to-kill-cancer-cells-a-mutual-enhancement-of-their-anticancer-actions
#1
Yang Jiao, Bethany N Hannafon, Roy R Zhang, Kar-Ming Fung, Wei-Qun Ding
We previously reported a synergistic anticancer action of clioquinol and docosahexaenoic acid (DHA) in human cancer cells. However, clioquinol has been banned from the clinic due to its neurotoxicity. This study identified disulfiram (DSF) as a substitute compound to clioquinol, acting in concert with DHA to more effectively kill cancer cells and suppress tumor growth. Treatment with DSF and DHA induced greater apoptotic cell death and suppression of tumor growth in vitro and in vivo, as compared to DSF and DHA used alone...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28100866/development-of-intra-knee-joint-sustained-release-gel-formulation-and-evaluation-of-its-pharmacological-efficiency-in-rats
#2
Takehiro Noda, Tomoyuki Okuda, Kousuke Ban, Ryota Mizuno, Tatsuaki Tagami, Tetsuya Ozeki, Hirokazu Okamoto
In the development of a drug for intra-articular administration, a sustained-release formulation is desirable since it is difficult to sustain the effects of conventional injections due to fast drug leakage from the joint cavity. In this study, we prepared sustained release gel formulations for intra-articular administration containing indocyanine green (ICG) as a model drug to follow its fate after intra-articular administration in rats with IVIS. ICG administered as an aqueous solution leaked from the joint cavity in a short time and was excreted out of the body within a day...
January 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28095823/tobacco-smoking-policies-in-australian-alcohol-and-other-drug-treatment-services-agreement-between-staff-awareness-and-the-written-policy-document
#3
Eliza Skelton, Billie Bonevski, Flora Tzelepis, Anthony Shakeshaft, Ashleigh Guillaumier, Adrian Dunlop, Sam McCrabb, Kerrin Palazzi
BACKGROUND: Comprehensive smoke-free policy in the alcohol and other drug (AOD) setting provides an opportunity to reduce tobacco related harms among clients and staff. This study aimed to examine within AOD services: staff awareness of their service's smoking policy compared to the written policy document and staff and service factors associated with accurate awareness of a total ban and perceived enforcement of a total ban. METHODS: An audit of written tobacco smoking policy documents and an online cross-sectional survey of staff from 31 Australian AOD services...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28093042/chloramphenicol-stereoisomers-need-to-be-distinguished-consequences-observed-from-a-proficiency-test
#4
Mark Sykes, Tobias Czymai, Thomas Hektor, Matthew Sharman, Michael Knaggs
Although the use of chloramphenicol (CAP) as a veterinary drug is banned in the European Union and many other countries, monitoring for CAP residues in food is routine. Positive detections are few, but taken extremely seriously. European Union laboratories analysing for CAP should validate methods according to European Commission Decision 2002/657/EC, must be accredited to ISO 17025, and will generally participate in proficiency testing (PT) schemes, such as those offered by the Food Analysis Performance Assessment Scheme (FAPAS®)...
January 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28076528/the-brief-life-of-norplant%C3%A2-in-brazil-controversies-and-reassemblages-between-science-society-and-state
#5
Ana Cristina de Lima Pimentel, Cláudia Bonan Jannotti, Paula Gaudenzi, Luiz Antonio da Silva Teixeira
Norplant® is the brand name of the world's first registered subdermal hormonal contraceptive implant, developed by the laboratories of the Population Council, an international organisation working in the area of fertility and population growth. The article revisits the trajectory of this contraceptive in Brazil from its arrival through clinical trials to its eventual ban in 1986 by the Brazilian regulatory agency responsible for approving medications at the time. Its circulation generated controversies related to research practices, side effects and political uses of the drug as a birth control method...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28072812/is-kratom-the-new-legal-high-on-the-block-the-case-of-an-emerging-opioid-receptor-agonist-with-substance-abuse-potential
#6
George C Chang-Chien, Charles A Odonkor, Prin Amorapanth
Kratom is an unscheduled opioid receptor agonist that comes in the form of dietary supplements currently being abused by chronic pain patients on prescription opioids. Active alkaloids isolated from kratom such as mitragynine and 7-hydroxymitragynine are thought to act on mu- and delta-opioid receptors as well as alpha-2 adrenergic and 5-HT2A receptors. Animal studies suggest that kratom may be more potent than morphine. Consequently, kratom consumption produces analgesic and euphoric feelings among users. In particular, some chronic pain patients on opioids take kratom to counteract the effects of opioid withdrawal...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28066659/percutaneous-epicardial-ablation-of-incessant-atrial-tachycardia-originating-from-the-left-atrial-appendage
#7
Ji-Eun Ban, Tae Young Park, Sang-Weon Park
A 38-year-old woman presented with antiarrhythmic drug-refractory atrial tachycardia (AT). Holter recording demonstrated incessant episodes of AT followed by a long sinus pause. Electrophysiologic study revealed that the earliest endocardial activation was observed at the neck of the left atrial appendage (LAA). After unsuccessful endocardial ablation, epicardial access via a percutaneous subxiphoid approach demonstrated that the earliest epicardial atrial activation was observed on the opposite site to the endocardial LAA neck suggestive of ligament of Marshall (LOM) muscle sleeve as regarding the epicardial sharp potentials under guidance of a circular mapping catheter...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28063756/-synthetic-cannabinoids-a-new-addiction-matrix
#8
Amandine Scocard, Amine Benyamina, Sarah Coscas, Laurent Karila
Synthetic cannabinoids (SC) belong to the emergent market of new psychoactive substances, sold on the Internet or specialized shops. Since the 1970s, more than 160 new SC have invaded the drug market. These substances imitate the psychoactive effects of cannabis. Underestimated for too long, SC's market growth and consequences are no longer to be ignored, first of all in terms of public health. SC were first synthesized during researches on the endocannabinoid system. Though they are agonists of the cannabinoid receptors 1 and 2, as Δ9-tetrahydrocannabinol in cannabis, they can also have a really high affinity with these receptors, rising up their potency...
January 4, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28054627/china-s-ivory-ban-spine-disease-drug-and-dark-matter-pioneer-dies
#9
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2017: Nature
https://www.readbyqxmd.com/read/28054434/in-vitro-phase-i-metabolism-of-selective-estrogen-receptor-modulators-in-horse-using-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#10
Karen Y Kwok, George H M Chan, Wai Him Kwok, Jenny K Y Wong, Terence S M Wan
Selective estrogen receptor modulators (SERMs) are chemicals that possess the anti-oestrogenic activities that are banned "in" and "out" of competition by the World Anti-Doping Agency (WADA) in human sports, and by the International Federation of Horseracing Authorities (IFHA) in horseracing. SERMs can be used as performance enhancing drugs to boost the level of androgens or to compensate for the adverse effects as a result of extensive use of androgenic anabolic steroids (AASs). SERMs have indeed been abused in human sports; hence, a similar threat can be envisaged in horseracing...
January 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28035171/the-case-of-a-needle-exchange-policy-debate-in-fresno-california
#11
Kris Clarke
Needle exchange is one of the most effective public health interventions to prevent the transmission of infectious disease by injecting drug users. Despite the preponderance of scientific evidence, US federal funding for needle exchange programmes has been banned since 1988. This prohibition has resulted in the lack of a centralised policy on needle exchange and has given birth to a patchwork of diverse practices and regulations throughout the nation. This article focuses on how various local players interpreted the meaning of needle exchange through the debate on an unauthorised site in Fresno, California...
May 2016: Crit Soc Policy
https://www.readbyqxmd.com/read/28034478/drug-policing-assemblages-repressive-drug-policies-and-the-zonal-banning-of-drug-users-in-denmark-s-club-land
#12
Thomas F Søgaard, Esben Houborg, Michael M Pedersen
BACKGROUND: Zonal banning of disorderly and intoxicated young people has moved to centre stage in debates about nightlife governance. Whereas existing research has primarily focused on the use of zonal banning orders to address problems of alcohol-related harm and disorder, this article highlights how zonal banning is also used to target drug-using clubbers in Denmark. METHODS: Based on ethnographic observations and interviews with nightlife control agents in two Danish cities, the article aims to provide new insights into how the enforcement of national drug policies on drug-using clubbers, is shaped by plural nightlife policing complexes...
December 26, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28030886/banned-devices-powdered-surgeon-s-gloves-powdered-patient-examination-gloves-and-absorbable-powder-for-lubricating-a-surgeon-s-glove-final-rule
#13
(no author information available yet)
The Food and Drug Administration (FDA or Agency) has determined that Powdered Surgeon's Gloves, Powdered Patient Examination Gloves, and Absorbable Powder for Lubricating a Surgeon's Glove present an unreasonable and substantial risk of illness or injury and that the risk cannot be corrected or eliminated by labeling or a change in labeling. Consequently, FDA is banning these devices.
19, 2016: Federal Register
https://www.readbyqxmd.com/read/28018115/dangerous-dietary-supplements-garcinia-cambogia-associated-hepatic-failure-requiring-transplantation
#14
Keri E Lunsford, Adam S Bodzin, Diego C Reino, Hanlin L Wang, Ronald W Busuttil
Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28012094/clinical-pharmacology-of-the-synthetic-cathinone-mephedrone
#15
Esther Papaseit, José Moltó, Robert Muga, Marta Torrens, Rafael de la Torre, Magí Farré
4-Methyl-N-methylcathinone (mephedrone) is a popular new psychoactive substance (NPS) that is structurally related to the parent compound cathinone, the β-keto analogue of amphetamine. Mephedrone appeared on the street drug market as a substitute for 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) and was subsequently banned due to the potential health risks associated with its use. Nevertheless, mephedrone continues to be widely consumed among specific populations, with unique patterns of misuse. To date, most information about the biological effects of mephedrone comes from user experiences, epidemiological data, clinical cases, toxicological findings, and animal studies, whilst there are very few data regarding its human pharmacodynamics and pharmacokinetics...
December 24, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27982189/gabapentin-differentially-modulate-c-fos-expression-in-hypothalamus-and-spinal-trigeminal-nucleus-in-surgical-molar-extraction
#16
Jamil Ahsan Kazi, Ban Kahtan Ibrahim
The study on the efficacy of oral analgesics reported that no single class of drug is effective in post-surgical dental pain. Pain following removal of third molar is most commonly used and widely accepted acute pain model for assessing the analgesic effect of drugs in humans. Reports demonstrated that analgesic efficacy in the human dental model is highly predictive. The high incidence of false-negative findings in analgesic investigations hinders the process of molecular discovery. Molecular mechanism of post-surgical pain is not known...
October 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27958719/detection-of-metoprolol-in-human-biofluids-and-pharmaceuticals-via-ion-transfer-voltammetry-at-the-nanoscopic-liquid-liquid-interface-array
#17
Xiao Huang, Lisiqi Xie, Xingyu Lin, Bin Su
Metoprolol (MTP) is one of the most widely used antihypertensive drugs yet banned to use in sport competition. Therefore, there has been an increasing demand for developing simple, rapid, and sensitive methods suited to the identification and quantification of MTP in human biofluids. In this work, ultrathin silica nanochannel membrane (SNM) with perforated channels was employed to support nanoscale liquid/liquid interface (nano-ITIES) array for investigation of the ion-transfer voltammetric behavior of MTP and for its detection in multiple human biofluids and pharmaceutical formulation...
December 13, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27937085/an-in-vitro-demonstration-of-overcoming-drug-resistance-in-skov3-tr-and-mcf7-adr-with-targeted-delivery-of-polymer-pro-drug-conjugates
#18
Prashant Bhattarai, Dylan Vance, Arash Hatefi, Ban An Khaw
Drug resistance is a common phenomenon that occurs in cancer chemotherapy. Delivery of chemotherapeutic agents as polymer pro-drug conjugates (PPDCs) pretargeted with bispecific antibodies could circumvent drug resistance in cancer cells. To demonstrate this approach to overcome drug resistance, Paclitaxel (Ptxl) resistant SKOV3 TR human ovarian- and doxorubicin (Dox) resistant MCF7 ADR human mammary-carcinoma cell lines were used. Pre-targeting over-expressed biotin or HER2/neu receptors on cancer cells was conducted by biotinylated anti-DTPA or Anti-HER2/neu affibody - anti-DTPA Fab bispecific antibody complexes...
December 12, 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27936903/paradoxical-increase-in-synthetic-cannabinoid-emergency-related-presentations-after-a-citywide-ban-lessons-from-houston-texas
#19
David Mathai, Mollie Gordon, Peter Muchmore, Anu Matorin, Asim Shah, Nidal Moukaddam
Synthetic cannabinoids (SCs) have become a major drug of abuse associated with severe hospital presentations. There have been a variety of legislative efforts to regulate these drugs: The authors focus on trends in SC-related hospitalizations at Ben Taub General Hospital before and after a ban enacted by the city of Houston. Data from all consults seen by Ben Taub's Licensed Chemical Dependency Counselor were examined for changes in SC-related presentations before and after the ban. The findings were compared alongside other reports of current SC use...
2016: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/27905700/use-of-ozone-depleting-substances-direct-final-rule
#20
(no author information available yet)
The Food and Drug Administration (FDA, the Agency, or we) is amending its regulation on uses of ozone-depleting substances (ODSs), including chlorofluorocarbons (CFCs), to remove the designation for certain products as "essential uses" under the Clean Air Act. Essential-use products are exempt from the ban by FDA on the use of CFCs and other ODS propellants in FDA-regulated products and from the ban by the Environmental Protection Agency (EPA) on the use of ODSs in pressurized dispensers. The products that will no longer constitute an essential use are: Sterile aerosol talc administered intrapleurally by thoracoscopy for human use and metered-dose atropine sulfate aerosol human drugs administered by oral inhalation...
October 26, 2016: Federal Register
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