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https://www.readbyqxmd.com/read/27905700/use-of-ozone-depleting-substances-direct-final-rule
#1
(no author information available yet)
The Food and Drug Administration (FDA, the Agency, or we) is amending its regulation on uses of ozone-depleting substances (ODSs), including chlorofluorocarbons (CFCs), to remove the designation for certain products as "essential uses" under the Clean Air Act. Essential-use products are exempt from the ban by FDA on the use of CFCs and other ODS propellants in FDA-regulated products and from the ban by the Environmental Protection Agency (EPA) on the use of ODSs in pressurized dispensers. The products that will no longer constitute an essential use are: Sterile aerosol talc administered intrapleurally by thoracoscopy for human use and metered-dose atropine sulfate aerosol human drugs administered by oral inhalation...
October 26, 2016: Federal Register
https://www.readbyqxmd.com/read/27904953/endometrial-preparation-with-dienogest-before-hysteroscopic-surgery-a-systematic-review
#2
Antonio Simone Laganà, Salvatore Giovanni Vitale, Vincenzo Muscia, Paola Rossetti, Massimo Buscema, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Loretta Giunta, Vittorio Palmara, Roberta Granese, Helena Ban Frangež, Andrea Romano
PURPOSE: Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery...
November 30, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27896591/design-and-in-vitro-evaluation-of-bispecific-complexes-and-drug-conjugates-of-anticancer-peptide-lyp-1-in-human-breast-cancer
#3
Selin Seda Timur, Prashant Bhattarai, Reyhan Neslihan Gürsoy, İmran Vural, Ban-An Khaw
PURPOSE: LyP-1, a nine-amino-acid tumor homing peptide, selectively binds to its cognate receptor, p32. Overexpression of p32 in certain tumors should allow use of LyP-1 as a targeting agent for the delivery of therapeutic or diagnostic agents. Peptide conjugates are developed for enhanced pre-targeting of MDA-MB-231 breast cancer cells with peptide-antibody bispecific complexes and targeting with multiple-drug/-fluorophore-conjugated nano-polymers. METHODS: LyP-1-anti-DTPA bispecific antibody complexes (LyP-1-bsAbCx) were generated by conjugation of anti-DTPA antibody and LyP-1...
November 28, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#4
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27889115/new-psychoactive-substances-are-there-any-good-options-for-regulating-new-psychoactive-substances
#5
Peter Reuter, Bryce Pardo
Advances in chemistry, technology, and globalization have contributed to the rapid development and diffusion of NPS (new psychoactive substances), creating perhaps the most serious challenge to the century-old international drug control system and to national systems. Very little is known about the effects of these substances which fall outside of national and international controls. The predominant response to the flood of NPS has been the development of more expeditious methods of prohibiting a new chemical entity...
November 23, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27885819/annual-banned-substance-review-analytical-approaches-in-human-sports-drug-testing
#6
Mario Thevis, Tiia Kuuranne, Hans Geyer, Wilhelm Schänzer
There has been an immense amount of visibility of doping issues on the international stage over the past 12 months and the complexity of doping controls has been reiterated on various occasions. Hence, analytical test methods continuously being updated, expanded, and improved to provide specific, sensitive, and comprehensive test results in line with the World Anti-Doping Agency's (WADA) 2016 Prohibited List represent one of several critical cornerstones of doping controls. This enterprise necessitates expediting the (combined) exploitation of newly generated information on novel and/or superior target analytes for sports drug testing assays, drug elimination profiles, alternative test matrices, and recent advances in instrumental developments...
November 25, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27884504/a-critical-examination-of-the-definition-of-psychoactive-effect-in-australian-drug-legislation
#7
Monica J Barratt, Kate Seear, Kari Lancaster
As the number of new 'psychoactive substances' detected globally has risen exponentially, the policy response of assessing and prohibiting each new substance individually has become increasingly unworkable. In an attempt to disrupt the availability of new as-yet-unscheduled substances, Ireland (2010), Poland (2011), Romania (2012), New Zealand (2013), Australia (2015) and the United Kingdom (2016) have enacted generic or blanket ban legislation that prohibits all 'psychoactive substances' that are not already regulated or belong to exempt categories...
November 21, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27880942/acquired-resistance-to-braf-inhibition-induces-epithelial-to-mesenchymal-transition-in-braf-v600e-mutant-thyroid-cancer-by-c-met-mediated-akt-activation
#8
Hyung Kwon Byeon, Hwi Jung Na, Yeon Ju Yang, Sooah Ko, Sun Och Yoon, Minhee Ku, Jaemoon Yang, Jae Wook Kim, Myung Jin Ban, Ji-Hoon Kim, Da Hee Kim, Jung Min Kim, Eun Chang Choi, Chang-Hoon Kim, Joo-Heon Yoon, Yoon Woo Koh
Previously, the authors have identified that c-Met mediates reactivation of the PI3K/AKT pathway following BRAF inhibitor treatment in BRAF (V600E) mutant anaplastic thyroid cancer, thereby contributing to the acquired drug resistance. Therefore dual inhibition of BRAF and c-Met led to sustained treatment response, thereby maximizing the specific anti-tumor effect of targeted therapy. The present study goes one step further and aims to investigate the effect of acquired resistance of BRAF inhibitor on epithelial-to-mesenchymal transition (EMT) in BRAF mutant thyroid cancer cells and the effect of dual inhibition from combinatorial therapy...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27868200/impact-of-copayment-changes-on-children-s-albuterol-inhaler-use-and-costs-after-the-clean-air-act-chlorofluorocarbon-ban
#9
Alison A Galbraith, Vicki Fung, Lingling Li, Melissa G Butler, James D Nordin, John Hsu, David Smith, William M Vollmer, Tracy A Lieu, Stephen B Soumerai, Ann Chen Wu
OBJECTIVE: To examine changes in children's albuterol use and out-of-pocket (OOP) costs in response to increased copayments after the Food and Drug Administration banned inhalers with chlorofluorocarbon (CFC) propellants. SETTING: Four health maintenance organizations (HMOs), two that increased copayments for albuterol inhalers that went from generic CFC-containing to branded CFC-free versions, and two that retained generic copayments for CFC-free inhalers (controls)...
November 20, 2016: Health Services Research
https://www.readbyqxmd.com/read/27856120/gifts-and-influence-conflict-of-interest-policies-and-prescribing-of-psychotropic-medications-in-the-united-states
#10
Marissa King, Peter S Bearman
The pharmaceutical industry spends roughly 15 billion dollars annually on detailing - providing gifts, information, samples, trips, honoraria and other inducements - to physicians in order to encourage them to prescribe their drugs. In response, several states in the United States adopted policies that restrict detailing. Some states banned gifts from pharmaceutical companies to doctors, other states simply required physicians to disclose the gifts they receive, while most states allowed unrestricted detailing...
November 9, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27845609/bovine-teeth-as-a-novel-matrix-for-the-control-of-the-food-chain-liquid-chromatography-tandem-mass-spectrometry-detection-of-treatments-with-prednisolone-dexamethasone-estradiol-nandrolone-and-seven-%C3%AE-2-agonists
#11
Luca Maria Chiesa, Maria Nobile, Sara Panseri, Bartolomeo Biolatti, Francesca Tiziana Cannizzo, Radmila Pavlovic, Francesco Arioli
Veterinary drugs usually have rapid clearance rates in the liver and kidney, hampering their detection in conventional matrices such as the liver or urine. Pharmacological principles such as esterification may be applied to facilitate the administration of veterinary drugs and increase drug half-life. Prednisolone, whose therapeutic administration is regulated for food producing animals in the EU, is available in its acetate form as well as nandrolone, a banned anabolic steroid, which may be obtained as nandrolone phenylpropionate and estradiol as a benzoyl ester...
November 15, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27843958/evaluation-of-prescriptions-of-medicines-not-included-in-iran-medicine-list-a-cross-sectional-study
#12
Marzieh Zargaran, Shekoufeh Nikfar, Abdol Majid Cheraghali
OBJECTIVE: Iran Food and Drug Administration (IFDA) has the mission to regulate all aspects of pharmaceutical market including registration of the new medicines. Iran Drug Selection Committee has the responsibility to maintain and revise Iran Medicine List (IML). The National law has banned production, importation, distribution, and prescription of medicines not included in IML. Although, IFDA policy makers have created a mechanism to provide medicines not included in the list but might be essential for the treatment of specific patients...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27825165/lignans-extracted-from-eucommia-ulmoides-oliv-protects-against-ages-induced-retinal-endothelial-cell-injury
#13
Ban Liu, Chao-Peng Li, Wen-Qi Wang, Shu-Guang Song, Xiu-Ming Liu
BACKGROUND/AIMS: Advanced glycation end products (AGEs) could elicit oxidative stress, trigger and aggravate endothelium damage in several ischemic retinopathies including diabetic retinopathy (DR). The leaves of Eucommia ulmoides O., also referred to as Tu-chung or Du-zhong, have been used for the treatment of hypertension and diabetes, showing great antioxidant activity and anti-glycation activity. Lignans is one of the main bioactive components of Eucommia ulmoides. This study mainly investigated the effect of lignans treatment on AGEs-induced endothelium damage...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27805264/identification-of-phenotypic-clusters-of-nonsteroidal-anti-inflammatory-drugs-exacerbated-respiratory-disease
#14
H Y Lee, Y M Ye, S H Kim, G Y Ban, S C Kim, J H Kim, Y S Shin, H S Park
BACKGROUND: Clinical presentation of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters to determine NERD subtypes. METHODS: We performed two-step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a NERD cohort comprising 302 patients. Asthma exacerbation was defined as receiving at least one burst of intravenous steroid treatment and/or at least two bursts of oral steroid use (≥ 45 mg/3 days) per year...
November 2, 2016: Allergy
https://www.readbyqxmd.com/read/27803693/the-risk-of-some-veterinary-antimicrobial-agents-on-public-health-associated-with-antimicrobial-resistance-and-their-molecular-basis
#15
REVIEW
Haihong Hao, Pascal Sander, Zahid Iqbal, Yulian Wang, Guyue Cheng, Zonghui Yuan
The risk of antimicrobial agents used in food-producing animals on public health associated with antimicrobial resistance continues to be a current topic of discussion as related to animal and human public health. In the present review, resistance monitoring data, and risk assessment results of some important antimicrobial agents were cited to elucidate the possible association of antimicrobial use in food animals and antimicrobial resistance in humans. From the selected examples, it was apparent from reviewing the published scientific literature that the ban on use of some antimicrobial agents (e...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#16
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
Background Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. Methods We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
October 31, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27769449/a-highly-selective-electrochemical-sensor-for-chloramphenicol-based-on-three-dimensional-reduced-graphene-oxide-architectures
#17
Xuan Zhang, Yi-Chi Zhang, Jia-Wei Zhang
Chloramphenicol (CAP), as a broad-spectrum antibiotic, has been worldwide banned for using in the food producing animals due to its overuse may cause severe threats to public health. It is therefore highly desirable to develop facile, selective and sensitive biosensor for CAP detection and monitoring in drug and foodstuff samples. In this work, three-dimensional reduced graphene oxide (3DRGO) architectures were prepared through a green and template-free approach and used as active electrode materials to develop a highly selective electrochemical sensor for CAP detection...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27736758/triclosan-an-instructive-tale
#18
Patrick J McNamara, Stuart B Levy
The Food and Drug Administration (FDA) recently released a final rule to ban triclosan and 18 other antimicrobial chemicals from soaps. We applaud this rule specifically because of the associated risks that triclosan poses to the spread of antibiotic resistance throughout the environment. This persistent chemical constantly stresses bacteria to adapt, and behavior that promotes antibiotic resistance needs to be stopped immediately when the benefits are null.
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27734824/-cannabinoid-and-cathinone-designer-drugs-the-workings-and-selected-methods-of-analysis
#19
REVIEW
Jadwiga Nędza, Renata Polaniak, Rafał J Bułdak, Milena Majchrzak, Joanna Margasiń-Ska, Marcin Rojkiewicz, Rafał Celiński, Elżbieta Grochowska-Niedworok
Recently, there has been an increase in the consumption of designer drugs, substances aimed at producing psychoactive, energizing, euphoric or anesthetic effects. Designer drugs are substitutes of actual narcotics, whose possession is banned under Polish law according to the Act of 29 July 2005. The latest reports suggest that the number of synthetic psychoactive substances is increasing. In the span of 2012, a total of 28 new synthetic cannabinoids were discovered in member states of the European Union. Synthetic psychoactive substances appear in different forms on the market: tablets (often very colourful and interestingly-shaped), seeds, dried product (sprayed with synthetic substance and redried), crystals or powder...
July 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27726019/effects-of-oral-administration-of-whole-plants-of-artemisia-annua-on-ichthyophthirius-multifiliis-and-aeromonas-hydrophila-after-parasitism-by-i-multifiliis
#20
Zhibin Wu, Fei Ling, Chenguang Song, Weichao Chen, Gaoxue Wang
Since the use of malachite green was banned, it is desirable to search for alternative drug to control Ichthyophthirius multifiliis infection. Moreover, route of administration which is easy to implement and less stressful to fish is important to treat infection of fish with this parasite. It is also important to enhance protective effect against Aeromonas hydrophila infection after parasitism by I. multifiliis. The present study evaluated the protective effect of diet supplemented with Artemisia annua against I...
October 10, 2016: Parasitology Research
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