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https://www.readbyqxmd.com/read/28431422/how-long-is-too-long-the-prespiked-intravenous-debate
#1
Jennifer L Stedman, Joel M Yarmush, Minal C Joshi, Sangeetha Kamath, Joseph Schianodicola
BACKGROUND: As the number of operative cases increases, there is a greater emphasis on reducing inefficiency while maintaining patient safety. Recently, the issue of prespiking intravenous (IV) bags was raised. No study has assessed whether the risk of infection is related to the length of time a sterile (IV) fluid bag has been spiked. After completion of a pilot study revealed no microbial growth within 24 hours of an IV spike, a larger formal study was undertaken to determine whether there was an increased infection risk within 4 hours of spiking an intravenous fluid bag...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28431396/skeletal-muscle-measures-and-physical-function-in-older-adults-with-cancer-sarcopenia-or-myopenia
#2
Grant R Williams, Allison M Deal, Hyman B Muss, Marc S Weinberg, Hanna K Sanoff, Kirsten A Nyrop, Mackenzi Pergolotti, Shlomit Strulov Shachar
BACKGROUND: Skeletal muscle loss, commonly known as sarcopenia, is highly prevalent in older adults and linked with adverse outcomes in cancer, yet the definition and role of sarcopenia remains uncertain. The aim of this study was to examine the association of Computerized Tomography (CT) assessed skeletal muscle measures with physical function in older adults with cancer. RESULTS: CTs for 185 patients were available. Median age 73 (IQR 68-76) and 56.5% female. After controlling for sex and BMI, we found no evidence that SMI was associated with physical function impairments...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28431388/retention-and-transport-of-graphene-oxide-in-water-saturated-limestone-media
#3
Shunan Dong, Yuanyuan Sun, Bin Gao, Xiaoqing Shi, Hongxia Xu, Jianfeng Wu, Jichun Wu
In this work, column experiments were conducted to investigate the transport characteristics of graphene oxide (GO) nanoparticles in limestone media under various electrolytes, solution pH, and humic acid (HA) concentration conditions. In the limestone media, GO exhibited relatively low mobility with the mass recovery rate lower than 65.2%, even when solution ionic strength was low. The presence of HA enhanced its mobility. In addition, the presence of S(2-), a divalent anion, also promoted GO transport in limestone media compared to Cl(-) under similar ionic strength conditions through neutralizing more positive charge and thus diminishing the cation bridging...
April 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28431385/a-method-for-evaluating-the-pharmaceutical-deconjugation-potential-in-river-water-environments
#4
Takashi Azuma, Mao Ishida, Kanae Hisamatsu, Ayami Yunoki, Kana Otomo, Mari Kunitou, Mai Shimizu, Kaori Hosomaru, Shiori Mikata, Yoshiki Mino
A new enzymatic assay method that uses deconjugation enzymes was developed to evaluate the presence and extent of conjugated pharmaceuticals in the form of glucuronide conjugates or sulphate conjugates in river environments. First, acetaminophen glucuronide (Ace Glu) and acetaminophen sulphate (Ace Sul) were used as model conjugated pharmaceuticals to determine the appropriate combination of deconjugation enzymes and reaction conditions, including temperature, duration and pH. Next, we applied the defined method to 19 pharmaceuticals grouped into nine therapeutic classes that were chosen based on previously detected levels and frequencies in sewage and river water...
April 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28431382/childhood-maltreatment-preceding-depressive-disorder-at-age-18-years-a-prospective-brazilian-birth-cohort-study
#5
Erika Alejandra Giraldo Gallo, Christian Loret De Mola, Fernando Wehrmeister, Helen Gonçalves, Christian Kieling, Joseph Murray
BACKGROUND: Childhood maltreatment is linked with increased risk for mental illness in adolescence and adulthood. However, little evidence is available on whether different forms of maltreatment have specific effects, and no prospective studies in low- or middle-income countries have addressed this issue. METHODS: Participants in a population-based, birth cohort study in Pelotas, Brazil (N=3715) self-reported exposure to maltreatment (emotional abuse, physical neglect, physical abuse, sexual abuse, domestic violence) in confidential questionnaires at age 15 years, and were assessed for major depression in interviews at age 18 years, using the MINI...
April 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28431356/heavy-metals-pollution-levels-and-children-health-risk-assessment-of-yerevan-kindergartens-soils
#6
Gevorg Tepanosyan, Nairuhi Maghakyan, Lilit Sahakyan, Armen Saghatelyan
Children, the most vulnerable urban population group, are exceptionally sensitive to polluted environments, particularly urban soils, which can lead to adverse health effects upon exposure. In this study, the total concentrations of Ag, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Ti, V, and Zn were determined in 111 topsoil samples collected from kindergartens in Yerevan. The objectives of this study were to evaluate heavy metal pollution levels of kindergarten's soils in Yerevan, compare with national legal and international requirements on heavy metal contents in kindergarten soil, and assess related child health risk...
April 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28431318/assessing-seasonal-variation-of-synthetic-musks-in-beach-sands-from-oporto-coastal-area-a-case-study
#7
Vera Homem, Inês Magalhães, Arminda Alves, Lúcia Santos
Synthetic musk compounds are widely used in the formulation of several cosmetics, personal care and household products. Due to their massive and widespread use, together with some health concerns, they are considered emerging pollutants and have been detected in different environmental compartments. This study focused on the evaluation of the concentration of synthetic musks (five nitro, five polycyclic and one macrocyclic musks) in beach sands, from Oporto coastal area (Portugal), contributing to the enhancement of the knowledge of levels, trends and behaviour of these compounds in this particular matrix...
April 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28431302/quality-of-life-in-survivors-of-oropharyngeal-cancer-a%C3%A2-systematic-review-and-meta-analysis-of-1366-patients
#8
REVIEW
Sanne Høxbroe Michaelsen, Christian Grønhøj, Jacob Høxbroe Michaelsen, Jeppe Friborg, Christian von Buchwald
Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is rapidly increasing in incidence and has a favourable prognosis compared with HPV-negative disease. Current combined therapies include significant risks of morbidity for the growing group of survivors. This systematic review and meta-analysis investigates how treatment affects quality of life (QoL) in survivors of oropharyngeal cancer. PubMed, EMBASE and the Cochrane Library were systematically searched for all studies reporting patient-assessed QoL at least 1 year after treatment for OPC...
April 18, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28431274/distribution-of-escherichia-coli-o157-h7-in-ground-beef-assessing-the-clustering-intensity-for-an-industrial-scale-grinder-and-a-low-and-localized-initial-contamination
#9
Estelle Loukiadis, Clémence Bièche-Terrier, Catherine Malayrat, Franck Ferré, Philippe Cartier, Jean-Christophe Augustin
Undercooked ground beef is regularly implicated in food-borne outbreaks involving pathogenic Shiga toxin-producing Escherichia coli. The dispersion of bacteria during mixing processes is of major concern for quantitative microbiological risk assessment since clustering will influence the number of bacteria the consumers might get exposed to as well as the performance of sampling plans used to detect contaminated ground beef batches. In this study, batches of 25kg of ground beef were manufactured according to a process mimicking an industrial-scale grinding with three successive steps: primary grinding, mixing and final grinding...
March 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28431270/clinicians-conflicting-emotional-responses-to-high-suicide-risk-patients-association-with-short-term-suicide-behaviors-a-prospective-pilot-study
#10
Zimri S Yaseen, Igor I Galynker, Lisa J Cohen, Jessica Briggs
BACKGROUND: Clinician's emotional responses to patients have been recognized as potentially relating to treatment outcome, however they have received little attention in the literature on suicide risk. We examine the relationship between a novel targeted measure of clinicians' emotional responses to high-risk psychiatric inpatients and their short-term post-discharge suicide behavior. METHODS: First-year psychiatry residents' emotional responses to their patients were assessed anonymously with the novel self-report 'Therapist Response Questionnaire-Suicide Form' (TRQ-SF)...
April 6, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28431264/intercomparison-of-methods-to-estimate-black-carbon-emissions-from-cookstoves
#11
Candela de la Sota, Moustapha Kane, Javier Mazorra, Julio Lumbreras, Issakha Youm, Mar Viana
Black carbon is the second largest contributor to climate change and also poses risks to human health. Despite the need for black carbon (BC) emissions estimates from residential biomass burning for cooking, quantitative data are still scarce. This scarcity is mainly due to the scattered location of the stoves, as well as relatively costly and complex analytical methods available. Two low cost and easy-to-use optical methods, a cell-phone based system and smoke stain reflectometry, where compared to elemental carbon (EC) concentrations by the Sunset OCEC Analyzer (TOT)...
April 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28431202/pharmacological-interventions-for-acute-pancreatitis
#12
REVIEW
Elisabetta Moggia, Rahul Koti, Ajay P Belgaumkar, Federico Fazio, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. OBJECTIVES: To assess the effects of different pharmacological interventions in people with acute pancreatitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28431198/serum-amylase-and-lipase-and-urinary-trypsinogen-and-amylase-for-diagnosis-of-acute-pancreatitis
#13
REVIEW
Gianluca Rompianesi, Angus Hann, Oluyemi Komolafe, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: The treatment of people with acute abdominal pain differs if they have acute pancreatitis. It is important to know the diagnostic accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis, so that an informed decision can be made as to whether the person with abdominal pain has acute pancreatitis. There is currently no Cochrane review of the diagnostic test accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28431186/unfractionated-heparin-versus-low-molecular-weight-heparins-for-avoiding-heparin-induced-thrombocytopenia-in-postoperative-patients
#14
REVIEW
Daniela R Junqueira, Liliane M Zorzela, Edson Perini
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction presenting as a prothrombotic disorder related to antibody-mediated platelet activation. It is a paradoxical immune reaction resulting in thrombin generation in vivo, which leads to a hypercoagulable state and the potential to initiate venous or arterial thrombosis. A number of factors are thought to influence the incidence of HIT including the type and preparation of heparin (unfractionated heparin (UFH) or low molecular weight heparin (LMWH)) and the heparin-exposed patient population, with the postoperative patient population at higher risk...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28431170/early-total-enteral-feeding-in-stable-very-low-birth-weight-infants-a-before-and-after-study
#15
Sushma Nangia, Amit Bishnoi, Ankita Goel, Piali Mandal, Soumya Tiwari, Arvind Saili
Background: Fear of necrotizing enterocolitis (NEC) has perpetuated delayed initiation and slow advancement of enteral feeding in very low birth weight (VLBW) infants with inherent risks of parenteral alimentation. The objective of this study was to assess effect of early total enteral feeding (ETEF) on day of achievement of full enteral feeds, feed intolerance, NEC and sepsis. Methods: In total, 208 stable VLBW neonates (28-34 weeks) admitted during 6 month periods of three consecutive years were enrolled...
April 18, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28431157/agreement-between-renal-prescribing-references-and-determination-of-prescribing-appropriateness-in-hospitalised-patients-with-chronic-kidney-disease
#16
Michelle O'Shaughnessy, Niamh Allen, John O'Regan, Edwina Payne-Danson, Lise Mentre, Dawn Davin, Peter Lavin, Tamasine Grimes
Background: Chronic kidney disease (CKD) is a risk factor for adverse drug events. The clinical significance of discordance between renal prescribing references is unknown. Aim: We determined the prevalence of potentially inappropriate prescribing (PIP) in CKD, measured agreement between two prescribing references, and assessed potential for harm consequent to PIP. Design: Single-centre observational study. Methods: A random sample of hospitalised patients with CKD were grouped according to baseline CKD stage (3, 4, or 5)...
April 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28431130/safety-concerns-with-thoracoabdominal-acupuncture-experience-at-a-tertiary-care-emergency-department
#17
Hak Jin Lee, Youn-Jung Kim, Won Young Kim
Objective.:  To evaluate serious complications caused by acupuncture treatment and to increase awareness of this complication. Design.:  A retrospective observational study. Setting. : At the emergency department of a tertiary hospital in an urban area during a five-year period (2010-2014) in Seoul, Korea. Subjects.:  Patients with postacupuncture mechanical complications in the thoracoabdominal region. Methods...
April 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28431063/left-ventricular-dysfunction-is-associated-with-frequent-premature-ventricular-complexes-and-asymptomatic-ventricular-tachycardia-in-children
#18
R A Bertels, L M Harteveld, L H Filippini, S A Clur, N A Blom
Aims: To assess the risk factors for left ventricular (LV) dysfunction in a paediatric population with idiopathic frequent premature ventricular contractions (PVCs) and asymptomatic ventricular tachycardias (VTs). Methods and Results: Paediatric patients with the diagnosis of idiopathic frequent PVCs and asymptomatic VTs were retrospectively evaluated. Frequent PVCs were defined as ≥5% on 24 h Holter recording. Left ventricular dysfunction was defined as a shortening fraction of ≤28%...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28431051/safety-long-term-outcomes-and-predictors-of-recurrence-after-first-line-combined-endoepicardial-ventricular-tachycardia-substrate-ablation-in-arrhythmogenic-cardiomyopathy-impact-of-arrhythmic-substrate-distribution-pattern-a-prospective-multicentre-study
#19
Antonio Berruezo, Juan Acosta, Juan Fernández-Armenta, Alonso Pedrote, Alberto Barrera, Eduardo Arana-Rueda, Andrés Ignacio Bodegas, Ignasi Anguera, Luis Tercedor, Diego Penela, David Andreu, Rosario Jesus Perea, Susana Prat-González, Lluis Mont
Background: First-line endoepicardial ventricular tachycardia (VT) ablation has been proposed for patients with arrhythmogenic cardiomyopathy (AC). This study reports procedural safety, outcomes, and predictors of recurrence. Methods and Results: Forty-one consecutive patients [12 with left ventricle (LV) involvement, 7 left-dominant] underwent first-line endoepicardial VT substrate ablation. Standard bipolar and unipolar thresholds were used to define low-voltage areas (LVA)...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28431050/role-of-adenosine-guided-pulmonary-vein-isolation-in-patients-undergoing-catheter-ablation-for-atrial-fibrillation-a-meta-analysis
#20
Yi-He Chen, Hui Lin, Cheng-Long Xie, Jian-Wen Hou, Yi-Gang Li
Aims: Adenosine had been reported to unmask dormant conduction and thus identify pulmonary vein at risk of reconnection. However, the role of adjunctive adenosine infusion after pulmonary vein isolation (PVI) on long-term arrhythmia-free survival was still contentious. The purpose of the present meta-analysis was to assess the association of adenosine testing with long-term ablation success in patients with atrial fibrillation (AF) (i.e. freedom from AF recurrence). Methods and Results: We systematically searched the electronic databases and finally included 10 studies, with 1771 patients undergoing adenosine-guided PVI and 1787 patients undergoing conventional PVI...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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