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Meconium aspiration syndrom

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https://www.readbyqxmd.com/read/27817768/-clinical-effect-of-high-frequency-oscillatory-ventilation-combined-with-pulmonary-surfactant-in-treatment-of-neonatal-severe-meconium-aspiration-syndrome-complicated-by-pulmonary-hemorrhage
#1
Jing Huang, Xin-Zhu Lin, Zhi Zheng
OBJECTIVE: To study the clinical effect and safety of high-frequency oscillatory ventilation (HFOV) combined with pulmonary surfactant (PS) in the treatment of neonatal severe meconium aspiration syndrome (MAS) complicated by neonatal pulmonary hemorrhage (NPH). METHODS: A total of 48 children with severe MAS complicated by NPH were enrolled, and a retrospective analysis was performed for the clinical effects of HFOV+PS (trial group, 25 children) and HFOV alone (control group, 23 children)...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27809298/meconium-exposure-and-autism-risk
#2
K M Miller, G Xing, C K Walker
OBJECTIVE: This study aims to determine whether fetal meconium passage is associated with autism. STUDY DESIGN: This retrospective birth cohort analysis of 9 945 896 children born in California 1991 to 2008 linked discharge diagnosis and procedure codes for prenatal stressors, meconium-stained amniotic fluid (MSAF) and meconium aspiration syndrome (MAS) with autism diagnoses for 47 277 children through 2012. We assessed the relative risk of autism by meconium status using logistic regression, adjusting for demographic and clinical features...
November 3, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27807253/lung-ultrasonography-to-diagnose-meconium-aspiration-syndrome-of-the-newborn
#3
Jing Liu, Hai-Ying Cao, Wei Fu
OBJECTIVE: To investigate the diagnostic value of lung ultrasonography for neonatal meconium aspiration syndrome (MAS). METHODS: This prospective observational study enrolled patients diagnosed with MAS based on medical history, clinical manifestations and chest X-ray and control newborns without MAS. During ultrasonography, each lung was divided into three regions (front, lateral, and back), using anterior and posterior axillary lines as the boundary. While scanning each region of the lungs, the hand piece was perpendicular or parallel to the ribs...
November 1, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27670556/management-of-patients-with-gastroschisis-requiring-extracorporeal-membrane-oxygenation-for-concurrent-respiratory-failure
#4
Alykhan Lalani, P Benson Ham, Linda J Wise, John M Daniel, K Christian Walters, Walter L Pipkin, Brian Stansfield, Robyn M Hatley, Jatinder Bhatia
Treatment of gastroschisis often requires multiple surgical procedures to re-establish abdominal domain, reduce abdominal contents, and eventually close the abdominal wall. In patients who have concomitant respiratory failure requiring extracorporeal membrane oxygenation (ECMO), this process becomes further complicated. This situation is rare and only five such cases have been reported in the ECMO registry database. Management of three of the five patients along with results and implications for future care of similar patients is discussed here...
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27628193/dmbt1-promotes-basal-and-meconium-induced-nitric-oxide-production-in-human-lung-epithelial-cells-in-vitro
#5
Hanna Müller, Christel Weiss, Marcus Renner, Ursula Felderhoff-Müser, Jan Mollenhauer
Meconium aspiration syndrome (MAS) is characterized by surfactant inactivation and inflammation. As lung epithelial cells up-regulate nitric oxide (NO) in response to inflammation, the NO production following meconium exposition was examined in relation to expression of Deleted in Malignant Brain Tumors 1 (DMBT1), a protein with functions in innate immunity and inflammatory regulation. Here, DMBT1 expression was analyzed by immunohistochemistry in postmortem lung sections from patients with MAS. The lung epithelial cell line A549, stably transfected with a DMBT1 (DMBT1+ cells) expression plasmid or with an empty expression plasmid (DMBT1- cells), was exposed to meconium...
September 15, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27589542/effect-of-early-adjunctive-use-of-oral-sildenafil-and-inhaled-nitric-oxide-on-the-outcome-of-pulmonary-hypertension-in-newborn-infants-a-feasibility-study
#6
S Al Omar, H Salama, M Al Hail, H Al Rifai, M Bunahia, W El Kasem, F J Siddiqui, M Dilawar, H Yassin, F Masud, A Mohamed, A Mansour
INTRODUCTION: Inhaled nitric oxide (iNO) is the standard therapy for infants with persistent pulmonary hypertension of the newborn (PPHN). Recently, sildenafil has been evaluated as an alternative or adjunctive pulmonary vasodilator. OBJECTIVE: To assess the effectiveness of adding sildenafil as an early adjunctive therapy together with iNO when treating newborns with PPHN and/or hypoxemic respiratory failure. METHODS: This is a randomized placebo trial on newborns with gestational age > 34 weeks, postnatal age < 48 hours, and diagnosed with PPHN (oxygen index (OI) ≥ 20)...
September 16, 2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27549510/the-burden-of-hypoxic-ischaemic-encephalopathy-in-malaysian-neonatal-intensive-care-units
#7
Nem-Yun Boo, Irene Guat-Sim Cheah
INTRODUCTION: This study aimed to determine the incidence of hypoxic-ischaemic encephalopathy (HIE) and predictors of HIE mortality in Malaysian neonatal intensive care units (NICUs). METHODS: This was a retrospective study of data from 37 NICUs in the Malaysian National Neonatal Registry in 2012. All newborns with gestational age ≥ 36 weeks, without major congenital malformations and fulfilling the criteria of HIE were included. RESULTS: There were 285,454 live births in these hospitals...
August 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27543379/risk-factors-for-necrotizing-enterocolitis-in-neonates-a-retrospective-case-control-study
#8
Qi Lu, Shupeng Cheng, Min Zhou, Jialin Yu
BACKGROUND: Necrotizing enterocolitis (NEC) in neonates is devastating, and risk-factor identification is crucial. This study aimed to evaluate risk factors for NEC in different gestational age (GA) groups. METHODS: Risk factors associated with NEC were investigated using a retrospective case-control design. Patients with Bell's Stage NEC≥II were divided into three groups based on GA: I, <34 weeks; II, ≥34 weeks but <37 weeks; III, ≥37 weeks. Each case was paired with two GA- and weight-matched controls...
June 22, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27479063/hypothermia-and-meconium-aspiration-syndrome-international-multicenter-retrospective-cohort-study
#9
Daniele De Luca, David G Tingay, Anton van Kaam, Werther Brunow de Carvalho, Eva Valverde, Charles Christoph Roehr, Fabio Mosca, Piero G Matassa, Olivier Danhaive, Virgilio P Carnielli, Marco Piastra
No abstract text is available yet for this article.
August 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27464019/maternal-super-obesity-and-neonatal-morbidity-after-term-cesarean-delivery
#10
Marcela C Smid, Catherine J Vladutiu, Sarah K Dotters-Katz, Tracy A Manuck, Kim A Boggess, David M Stamilio
Objective To estimate the association between maternal super obesity (body mass index [BMI] ≥ 50 kg/m(2)) and neonatal morbidity among neonates born via cesarean delivery (CD). Methods Retrospective cohort of singleton neonates delivered via CD ≥ 37 weeks in the Maternal-Fetal Medicine Unit Cesarean Registry. Maternal BMI at delivery was stratified as 18.5 to 29.9 kg/m(2), 30 to 39.9 kg/m(2), 40 to 49.9 kg/m(2), and ≥ 50 kg/m(2). Primary outcomes included acute (5-minute Apgar score < 5, cardiopulmonary resuscitation and ventilator support < 24 hours, neonatal injury, and/or transient tachypnea of the newborn) and severe (grade 3 or 4 intraventricular hemorrhage, necrotizing enterocolitis, seizure, respiratory distress syndrome, hypoxic ischemic encephalopathy, meconium aspiration, ventilator support ≥ 2 days, sepsis and/or neonatal death) neonatal morbidity...
October 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27407455/a-two-year-experience-in-continuous-positive-airway-pressure-ventilation-using-nasal-prongs-and-pulse-oximetry
#11
R K Malik, R K Gupta
In a prospective study 26 of the 116 consecutive neonates suffering from respiratory distress survived on varying concentrations of humidified oxygen. Continuous positive airway pressure (CPAP) of 4-12 cm of water was applied through short nasal prongs to 90 neonates. Haemoglobin oxygen saturation (SaO2) rose in all and it was maintained steadily above 85% in 46 (51%) infants who survived. The mean duration of CPAP among the survivors was 61 hours (range 8-190 hours). Common indications of CPAP ventilation were hyaline membrane disease (HMD) (27...
January 2003: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27382217/predictive-value-of-cerebroplacental-ratio-in-detection-of-perinatal-outcome-in-high-risk-pregnancies
#12
Rehana Najam, Sarika Gupta, Shalini
OBJECTIVE: To assess the predictive value of cerebroplacental ratio (i.e., S/D ratio of middle cerebral artery to S/D ratio of Umbilical artery) in detection of perinatal outcome in high-risk pregnancies. MATERIAL AND METHOD: This retrospective study was conducted on 150 patients between 28 and 40 weeks of gestation (25 low risk and 125 high risk) who attended OPD and indoor wards of Teerthanker Mahaveer medical college and research center, Moradabad. All patients had serial color Doppler ultrasounds done after taking informed consent which was repeated at 2 weeks interval, and data were collected with regard to perinatal outcome...
August 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27375325/meconium-aspiration-syndrome-an-insight
#13
U Raju, V Sondhi, S K Patnaik
Meconium aspiration syndrome (MAS) is respiratory distress in a newborn baby caused by the presence of meconium in the tracheobronchial airways. The aspiration of meconium stained amniotic fluid by the fetus can happen during antepartum or intrapartum periods and can result in airway obstruction, interference with alveolar gas exchange, chemical pneumonitis as well as surfactant dysfunction. These pulmonary effects cause gross ventilation-perfusion mismatching. To complicate matters further, many infants with MAS have primary or secondary persistent pulmonary hypertension of the newborn as a result of chronic in utero stress and thickening of the pulmonary vessels...
April 2010: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27283193/antiinflammatory-effect-of-n-acetylcysteine-combined-with-exogenous-surfactant-in-meconium-induced-lung-injury
#14
P Mikolka, J Kopincova, L Tomcikova Mikusiakova, P Kosutova, A Calkovska, D Mokra
Neonatal meconium aspiration syndrome (MAS) can be treated by exogenous surfactant (S). However, aspirated meconium initiates local inflammation and oxidation which may inactivate surfactant and reduce its action. This experimental study estimated whether combined use of surfactant and the antioxidant N-acetylcysteine (NAC) can enhance effectiveness of therapy. Meconium-instilled rabbits were non-treated (M), treated with monotherapies (M + S, M + NAC), combined therapy (M + S + NAC), or received saline instead of meconium (controls, C)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27266360/erythropoietin-may-attenuate-lung-inflammation-in-a-rat-model-of-meconium-aspiration-syndrome
#15
Ali Haydar Turhan, Aytuğ Atici, Necati Muşlu, Ayşe Polat, Mehmet Ali Sungur
BACKGROUND: Inflammation is believed to play a key role in the pathophysiology of meconium aspiration syndrome (MAS). PURPOSE OF THE STUDY: The objective was to determine whether the recombinant human Erythropoietin (rhEPO) pretreatment could attenuate meconium-induced inflammation. MATERIALS AND METHODS: In this study, 24 ventilated adult male rats were studied to examine the effects of recombinant human EPO (rhEPO) on meconium-induced inflammation...
May 2016: Experimental Lung Research
https://www.readbyqxmd.com/read/27255954/endotracheal-suction-in-term-non-vigorous-meconium-stained-neonates-a-pilot-study
#16
Sushma Nangia, Shyam Sunder, Ratna Biswas, Arvind Saili
AIM: To evaluate the effect of 'No endotracheal suction' on occurrence of meconium aspiration syndrome (MAS) and/or all-cause mortality in non-vigorous neonates born through meconium stained amniotic fluid (MSAF). METHODS: This pilot randomized controlled trial enrolled term non-vigorous neonates (≥37 weeks) born through MSAF. Neonates randomized to 'No Endotracheal suction group' ('No ET' Group; n=88) did not undergo endotracheal suction before the definitive steps of resuscitation...
August 2016: Resuscitation
https://www.readbyqxmd.com/read/27220313/lung-ultrasound-as-a-predictor-of-mechanical-ventilation-in-neonates-older-than-32-weeks
#17
Javier Rodríguez-Fanjul, Carla Balcells, Victoria Aldecoa-Bilbao, Julio Moreno, Martín Iriondo
BACKGROUND: The prognosis of neonatal respiratory distress may be difficult to estimate at admission. Lung ultrasound is a useful diagnostic tool that is quick, requires little training, and is radiation free. OBJECTIVE: This study aims to analyze whether early lung ultrasound can predict respiratory failure. METHODS: From January to December 2014, lung ultrasound was performed on neonates admitted with breathing difficulties if they were older than 32 weeks and not intubated...
2016: Neonatology
https://www.readbyqxmd.com/read/27206687/current-concepts-in-the-management-of-meconium-aspiration-syndrome
#18
REVIEW
Subhash Chettri, B Vishnu Bhat, B Adhisivam
In developing countries, meconium aspiration syndrome (MAS) is an important cause of morbidity and mortality among neonates. The concepts of pathophysiology and management of meconium stained amniotic fluid (MSAF) and meconium aspiration syndrome have undergone tremendous change in recent years. Routine intranatal and postnatal endotracheal suctioning of meconium in vigorous infants is no longer recommended. Recent studies have challenged its role even in non-vigorous infants. Supportive therapy like oxygen supplementation, mechanical ventilation and intravenous fluids are the cornerstone in the management of meconium aspiration syndrome...
October 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27173766/lowering-the-high-rate-of-caesarean-delivery-in-china-an-experience-from-shanghai
#19
X Liu, C D Lynch, W W Cheng, M B Landon
OBJECTIVE: To examine the trends of caesarean delivery (CD) after an intervention to lower the high rate of CD at a Chinese maternity hospital. DESIGN: Retrospective cohort study. SETTING: A large tertiary obstetric centre in Shanghai, China, from 2007 to 2014. SAMPLE: 81 459 nulliparous women who delivered a term singleton infant. METHODS: Logistic regression was used to calculate the odds of CD while adjusting for confounders...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27109092/surfactant-therapy-and-antibiotics-in-neonates-with-meconium-aspiration-syndrome-a-systematic-review-and-meta-analysis
#20
C K Natarajan, M J Sankar, K Jain, R Agarwal, V K Paul
Meconium aspiration syndrome (MAS), a common cause of respiratory failure in neonates, is associated with high mortality and morbidity. The objectives of this review were to evaluate the effects of administration of (a) surfactant-either as lung lavage (SLL) or bolus surfactant (BS) and (b) antibiotics on mortality and severe morbidities in neonates with MAS. We searched the following databases: MEDLINE via PubMed, Cochrane CENTRAL, WHOLIS and CABI using sensitive search strategies. We included eight studies on use of surfactant and three studies on use of antibiotics...
May 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
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