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https://www.readbyqxmd.com/read/22824011/the-immunopathogenesis-of-cow-s-milk-protein-allergy-cmpa
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Giovanna Vitaliti, Vitaliti Giovanna, Carla Cimino, Cimino Carla, Alfina Coco, Coco Alfina, Andrea Domenico Praticò, Praticò Andrea Domenico, Elena Lionetti, Lionetti Elena
The most frequent symptoms among the manifestations of cow milk protein allergy (CMPA) are gastrointestinal. CMPA pathogenesis involves immunological mechanisms with participation of immunocompetent cells and production of immunoglobulin E (IgE). Nevertheless, recent studies have been focused on the description of other forms of CMPA, not-mediated by IgE reactions, mostly involving the T lymphocite immune system. Thus, in this field it is important to note how different kind of cells are involved in the immunopathogenesis of CMPA, such as antigen-specific T cells, T regulatory cells, cytokines secreted by the different T lymphocite subsets, B lymphocytes, antingen-presenting cells, mast cells, that together orchestrate the complex mechanism leading to the phenotipic expression of CMPA...
2012: Italian Journal of Pediatrics
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