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https://www.readbyqxmd.com/read/28641364/access-to-coverage-and-care-for-people-with-preexisting-conditions-how-has-it-changed-under-the-aca
#1
Sherry Glied, Adlan Jackson
ISSUE: Prior to the Affordable Care Act (ACA), people with preexisting health conditions could be denied insurance coverage or charged higher rates. If the law is repealed, these protections could be diluted or lost altogether. GOALS: Assess the ACA's impact on coverage and access for people with preexisting conditions and compare their coverage gains with state high-risk-pool enrollment pre-ACA. METHODS: Analysis of Behavioral Risk Factor Surveillance System data for the period 2011–13 to 2015. KEY FINDINGS AND CONCLUSIONS: Between 2013 and 2015, 16...
June 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28641125/an-altered-redox-environment-assisted-by-over-expression-of-fetal-hemoglobins-protects-from-inflammatory-colitis-and-reduces-inflammatory-cytokine-expression
#2
R M Gorczynski, C Alexander, K Brandenburg, Z Chen, A Heini, D Neumann, J P Mach, E T Rietschel, A Tersikh, A J Ulmer, Kai Yu, U Zahringer, I Khatri
C5BL/6 female mice receiving dextran sodium sulfate in their drinking water develop an acute inflammatory colitis within 7d, with weight loss, histopathologic signs of inflammation, and colonic expression of inflammatory cytokines. In previous studies we have reported that increased inflammatory cytokine expression in aged mice can be attenuated by oral gavage of a crude fetal extract containing glutathione (GSH), MPLA and fetal hemoglobin, or more specifically by injection of a combination of these purified reagents...
June 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28641063/launching-adoptees-into-adulthood-mothers-and-fathers-promotion-of-volitional-functioning
#3
Sonia Ranieri, Laura Ferrari, Daniela Barni, Rosa Rosnati
In the psychological literature, there is growing evidence that parental support of children's volitional functioning is one of the most prominent protective factors during adolescence and the transition to adulthood. According to the Self-Determination Theory, children cope best with developmental tasks when they acquire a sense of self-governance and self-endorsed functioning. In the field of adoption research, however, the parental promotion of volitional functioning (PVF) and its relation to the adopted child's development are still underinvestigated...
July 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28641061/positive-parenting-as-responsible-care-risks-protective-factors-and-intervention-evaluation
#4
Silvia Donato, Anna Bertoni
In this themed issue of the Journal of Prevention & Intervention in the Community, the first four contributions provide knowledge on factors that can support or hinder positive parenting throughout children's lives. In particular, the first article examined the spillover of work stressors on parenting behaviors and the role of spousal support as a moderator of stress spillover. The second contribution examines the association between parents' promotion of volitional functioning and adopted children's sense of strength of family bonds and belonging to the adoptive family...
July 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28640941/phox2b-reliably-distinguishes-neuroblastoma-among-small-round-blue-cell-tumors
#5
Yin P Hung, John P Lee, Andrew M Bellizzi, Jason L Hornick
AIMS: Neuroblastoma shows considerable histologic overlap with other small round blue cell tumors. PHOX2B, a transcription factor essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The purpose of this study was to validate the specificity and diagnostic utility of PHOX2B for peripheral neuroblastic tumors. METHODS AND RESULTS: We evaluated 240 cases (133 in whole-tissue sections; 107 in tissue microarrays), including 76 peripheral neuroblastic tumors [median age 2 years; including 4 adults] and 164 other tumors: 44 Wilms tumors; 20 Ewing sarcomas; 10 each CIC-rearranged round cell sarcomas, poorly differentiated synovial sarcomas, lymphoblastic lymphomas, alveolar rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal chondrosarcomas, Merkel cell carcinomas, olfactory neuroblastomas, and melanomas; 5 each NUT midline carcinomas and desmoplastic small round cell tumors...
June 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28640888/mechanisms-of-acute-neurovascular-protection-with-at1-blockade-after-stroke-effect-of-prestroke-hypertension
#6
Ahmed Alhusban, Anna Kozak, Bindu Pillai, Heba Ahmed, Mohammed A Sayed, Maribeth H Johnson, Tauheed Ishrat, Adviye Ergul, Susan C Fagan
Stroke is a leading cause of adult disability worldwide. Improving stroke outcome requires an orchestrated interplay that involves up regulation of pro-survival pathways and a concomitant suppression of pro-apoptotic mediators. In this investigation, we assessed the involvement of eNOS in the AT1 blocker-mediated protective and pro-recovery effects in animals with hypertension. We also evaluated the effect of acute eNOS inhibition in hypertensive animals. To achieve these goals, spontaneously hypertensive rats (SHR) were implanted with blood pressure transmitters, and randomized to receive either an eNOS inhibitor (L-NIO) or saline one hour before cerebral ischemia induction...
2017: PloS One
https://www.readbyqxmd.com/read/28640661/attrition-from-antiretroviral-treatment-services-among-pregnant-and-non-pregnant-patients-following-adoption-of-option-b-in-haiti
#7
Jean Wysler Domercant, Nancy Puttkammer, Paul Young, Krista Yuhas, Kesner François, Reynold Grand'Pierre, David Lowrance, Michelle Adler
BACKGROUND: Access to antiretroviral therapy (ART) has expanded in Haiti because of the adoption of Option B+ and the revision of treatment guidelines. Retention in care and treatment varies greatly and few studies have examined retention rates, particularly among women enrolled in Option B+. OBJECTIVE: To assess attrition among pregnant and non-pregnant patients initiating ART following adoption of Option B+ in Haiti. METHODS: Longitudinal data of adult patients initiated on ART from October 2012 through August 2014 at 73 health facilities across Haiti were analyzed using a survival analysis framework to determine levels of attrition...
2017: Global Health Action
https://www.readbyqxmd.com/read/28637322/predicting-perceived-isolation-among-midlife-and-older-lgbt-adults-the-role-of-welcoming-aging-service-providers
#8
Jie Yang, Yoosun Chu, Mary Anne Salmon
Background and Objectives: Older lesbian, gay, bisexual, and transgender (LGBT) adults are more likely to live alone and less likely to have children compared with their heterosexual counterparts. The lack of immediate family system can render older LGBT adults particularly vulnerable to social isolation and its consequences. The current study utilizes social exclusion theory, which asserts that not only material resources but also engagement with and inclusion into the society are necessary for marginalized people to be integrated into the mainstream...
June 16, 2017: Gerontologist
https://www.readbyqxmd.com/read/28637312/the-provision-of-healthcare-to-young-and-dependent-children-the-principles-concepts-and-utility-of-the-children-act-1989
#9
Jo Bridgeman
This article undertakes a thorough analysis of the case law concerned with the provision of healthcare to young and dependent children. It demonstrates how, despite the procedural changes introduced by the Children Act 1989 at an early stage in this body of case law, cases have continued to be brought to court by way of applications for the court to exercise its inherent jurisdiction or in wardship rather than using the orders introduced by the Act. In determining these cases, the court is focused upon its protective duty to the vulnerable but proceedings appear to be adversarial contests between the claims of adults to know what is best for the child in which the medical view normally prevails...
June 14, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28636880/behavioral-evidence-of-oxidative-stress-by-hematophagy-in-the-ocellar-system-of-rhodnius-prolixus-st%C3%A3-l-1859-red-eyed-mutants
#10
Carlos Alberto Vija Suarez, Mario Iván Ortiz, Jorge Molina
The photonegative response to light stimulation in Rhodnius prolixus (Reduviidae, Triatominae) is modulated by compound eyes and ocelli. Screening pigments in the visual system have been shown to protect the cellular structures from the oxidative stress damage produced by blood ingestion and light stimulation. Red-eyed mutants of Rhodnius prolixus lack screening pigments in their compound eyes and ocelli and are exposed to more oxidative stress. Experiments with Rhodnius prolixus and Triatoma infestans red-eyed mutants reared from the first nymphal stage show damage in the retinas of the compound eyes and a decrease in photonegative responses due to light stimulation...
June 18, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28636855/efficacy-of-recombinant-influenza-vaccine-in-adults-50-years-of-age-or-older
#11
Lisa M Dunkle, Ruvim Izikson, Peter Patriarca, Karen L Goldenthal, Derek Muse, Janice Callahan, Manon M J Cox
BACKGROUND: Improved influenza vaccines are needed to control seasonal epidemics. This trial compared the protective efficacy in older adults of a quadrivalent, recombinant influenza vaccine (RIV4) with a standard-dose, egg-grown, quadrivalent, inactivated influenza vaccine (IIV4) during the A/H3N2-predominant 2014-2015 influenza season, when antigenic mismatch between circulating and vaccine influenza strains resulted in the reduced effectiveness of many licensed vaccines. METHODS: We conducted a randomized, double-blind, multicenter trial of RIV4 (45 μg of recombinant hemagglutinin [HA] per strain, 180 μg of protein per dose) versus standard-dose IIV4 (15 μg of HA per strain, 60 μg of protein per dose) to compare the relative vaccine efficacy against reverse-transcriptase polymerase-chain-reaction (RT-PCR)-confirmed, protocol-defined, influenza-like illness caused by any influenza strain starting 14 days or more after vaccination in adults who were 50 years of age or older...
June 22, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28636782/changing-trends-in-complications-of-chronic-hepatitis-c
#12
Mei Lu, Jia Li, Loralee B Rupp, Yueren Zhou, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu H Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Sheri Trudeau, Stuart C Gordon
BACKGROUND AND AIMS: Chronic hepatitis C virus (HCV)-related complications have increased over the past decade. METHODS: We used join-point regression modeling to investigate trends in these complications from 2006-2015, and the impact of demographics on these trends. Using data from the Chronic Hepatitis Cohort Study (CHeCS), we identified points at which the trend significantly changed, and estimated the annual percent change (APC) in rates of cirrhosis, decompensated cirrhosis, and all-cause mortality, adjusted by race, sex, and age...
June 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28636773/comparison-of-different-insulin-pump-makes-under-routine-care-conditions-in-adults-with-type-1-diabetes
#13
L Leelarathna, S A Roberts, A Hindle, K Markakis, T Alam, A Chapman, J Morris, A Urwin, P Jinadev, M K Rutter
AIMS: To compare long-term HbA1c changes associated with different insulin pumps during routine care in a large cohort of adults with Type 1 diabetes representative of other clinic populations. METHODS: Observational, retrospective study of 508 individuals starting pump therapy between 1999 and 2014 (mean age, 40 years; 55% women; diabetes duration, 20 years; 94% Type 1 diabetes; median follow-up, 3.7 years). Mixed linear models compared covariate-adjusted HbA1c changes associated with different pump makes...
June 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28636736/the-protective-effect-of-intratympanic-dexamethasone-on-streptomycin-ototoxicity-in-rats
#14
Aylin Gül, Engin Şengül, Beyhan Yılmaz, Fazıl Emre Özkurt, Mehmet Akdağ, Ayşenur Keleş, İsmail Topçu
The purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28636413/tea-consumption-is-associated-with-cognitive-impairment-in-older-chinese-adults
#15
Ying-Jie Gu, Chun-Hong He, Su Li, Shu-Yi Zhang, Sheng-Yu Duan, Hong-Peng Sun, Yue-Ping Shen, Yong Xu, Jie-Yun Yin, Chen-Wei Pan
OBJECTIVE: To explore the association between tea consumption and cognitive impairment (CoI). METHODS: 4579 adults (≥60 years) from the Weitang Geratric Diseases Study were assessed for characteristics of tea consumption and cognitive function by administering questionnaires and the Abbreviated Mental Test (AMT), respectively. We divided the subjects into normal cognitive function group (AMT score ≥8) and CoI group (AMT score ≤7).   The association between tea consumption and risk of CoI was determined by logistic regression models...
June 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28636253/estimation-of-vanadium-water-quality-benchmarks-for-the-protection-of-aquatic-life-with-relevance-to-the-athabasca-oil-sands-region-using-species-sensitivity-distributions
#16
Stephanie Schiffer, Karsten Liber
Elevated vanadium (V) concentrations in oil sands coke, which is produced and stored on the site of some major Athabasca Oil Sands companies, could pose a risk to aquatic ecosystems in northern Alberta, Canada, depending on its future storage and utilization. In the present study, V toxicity was determined in reconstituted Athabasca River water to various freshwater organisms, including 2 midge species (Chironomus dilutus and Chironomus riparius; 4-d and 30- to 40-d exposures) and 2 freshwater fish species (Oncorhynchus mykiss and Pimephales promelas; 4-d and 28-d exposures) to facilitate estimation of water quality benchmarks...
June 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28635557/cellular-immune-responses-of-older-adults-to-four-influenza-vaccines-results-of-a-randomized-controlled-comparison
#17
Arun Kumar, Janet E McElhaney, Lisa Walrond, Terry D Cyr, Shahzma Merani, Tobias R Kollmann, Scott A Halperin, David W Scheifele
Cellular immunity is important for protection against the serious complications of influenza in older adults. As it is unclear if newer influenza vaccines elicit greater cellular responses than standard vaccines, we compared responses to two standard and two newer licensed trivalent inactivated vaccines (TIVs) in a randomized trial in older adults. Non-frail adults ≥65 years old were randomly assigned to receive standard subunit, MF59-adjuvanted subunit, standard split-virus or intradermal split-virus TIV...
June 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28635124/regular-aerobic-exercise-reduces-endothelin-1-mediated-vasoconstrictor-tone-in-overweight-and-obese-adults
#18
Caitlin A Dow, Brian L Stauffer, Danielle L Brunjes, Jared J Greiner, Christopher A DeSouza
Endothelin (ET)-1-mediated vasoconstrictor tone is elevated in overweight and obese adults, contributing to vasomotor dysfunction and increased cardiovascular disease risk. While the effects of habitual aerobic exercise on endothelium-dependent vasodilation in overweight/obese adults has been studied, little is known regarding ET-1 vasoconstriction. Accordingly, the aims of the present study were to determine: (1) if regular aerobic exercise training reduces ET-1-mediated vasoconstrictor tone in overweight and obese adults; and, if so (2) whether the reduction in ET-1 vasoconstriction contributes to exercise-induced improvement in endothelium-dependent vasodilation in this population...
June 20, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28634876/life-expectancy-gain-due-to-employment-status-depends-on-race-gender-education-and-their-intersections
#19
Shervin Assari
PURPOSE: Despite the well-established health effects of socioeconomic status (SES), SES resources such as employment may differently influence health outcomes across sub-populations. This study used a national sample of US adults to test if the effect of baseline employment (in 1986) on all-cause mortality over a 25-year period depends on race, gender, education level, and their intersections. METHODS: Data came from the Americans' Changing Lives (ACL) study, which followed 2025 Whites and 1156 Blacks for 25 years from 1986 to 2011...
June 20, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28634855/alpha-linolenic-acid-decreases-apoptosis-and-oxidized-phospholipids-in-cardiomyocytes-during-ischemia-reperfusion
#20
Riya Ganguly, Devin Hasanally, Aleksandra Stamenkovic, Thane G Maddaford, Rakesh Chaudhary, Grant N Pierce, Amir Ravandi
The omega-3 fatty acid, alpha linolenic acid (ALA) found in plant-derived foods induces significant cardiovascular benefits when ingested. ALA may be cardioprotective during ischemia; however, the mechanism(s) responsible for this effect is unknown. Isolated adult rat cardiomyocytes were exposed to medium containing ALA for 24 h and then exposed to non-ischemic (control), simulated ischemia (ISCH), or simulated ischemia/reperfusion (IR) conditions. Cardiomyocyte phospholipids were extracted and analyzed by an HPLC/electrospray ionization tandem mass spectrometry system...
June 20, 2017: Molecular and Cellular Biochemistry
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