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https://www.readbyqxmd.com/read/29655627/lipopolysaccharide-specific-memory-b-cell-responses-to-an-attenuated-live-cholera-vaccine-are-associated-with-protection-against-vibrio-cholerae-infection
#1
Douglas J Haney, Michael D Lock, Marc Gurwith, Jakub K Simon, Glenn Ishioka, Mitchell B Cohen, Beth D Kirkpatrick, Caroline E Lyon, Wilbur H Chen, Marcelo B Sztein, Myron M Levine, Jason B Harris
BACKGROUND: The single-dose live attenuated vaccine CVD 103-HgR protects against experimental Vibrio cholerae infection in cholera-naïve adults for at least 6 months after vaccination. While vaccine-induced vibriocidal seroconversion is associated with protection, vibriocidal titers decline rapidly from their peak 1-2 weeks after vaccination. Although vaccine-induced memory B cells (MBCs) might mediate sustained protection in individuals without detectable circulating antibodies, it is unknown whether oral cholera vaccination induces a MBC response...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29653301/the-moderating-role-of-resilience-on-the-relationship-between-perceived-stress-and-binge-eating-symptoms-among-young-adult-women
#2
Idia B Thurston, Robin Hardin, Rebecca C Kamody, Sylvia Herbozo, Caroline Kaufman
OBJECTIVE: Adolescence and young adulthood are developmental periods during the life course that are sometimes associated with heightened stress and engagement in binge eating. Binge eating has been linked to psychiatric comorbidity, poorer physical health, and lower quality of life. However, less is known about protective factors that could buffer against binge eating behaviors. The current study examined the moderating role of resilience on the relationship between perceived stress and binge eating symptoms among emerging adult female college students...
April 2, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29653205/varicella-zoster-virus-reactivation-in-adult-survivors-of-hematopoietic-cell-transplantation-how-do-we-best-protect-our-patients
#3
REVIEW
Catherine J Lee, Bipin N Savani, Per Ljungman
Reactivation of varicella zoster virus (VZV) remains a significant public health burden for long-term survivors of hematopoietic cell transplantation. Delayed immune reconstitution after transplantation due to immunosuppression, posttransplant therapies, poor engraftment, and graft-versus-host disease leave a large number of patients at risk for herpes zoster (shingles) and its highly morbid complications. Although prophylaxis with acyclovir or valacyclovir has reduced the incidence of VZV reactivation as long as prophylaxis is continued, the incidence of disease in the late posttransplant period or after stopping prophylaxis is greater in the HCT population than the general public...
April 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29653018/brain-complications-of-diabetes-mellitus-a-cross-sectional-study-of-awareness-among-individuals-with-diabetes-and-the-general-population-in-ireland
#4
C Dolan, R Glynn, S Griffin, C Conroy, C Loftus, P C Wiehe, M L Healy, B Lawlor
AIMS: To identify awareness of potential brain complications of diabetes among individuals with diabetes and the public. METHODS: For this observational, cross-sectional survey study, we recruited consecutive adult attendees of a specialist diabetes clinic and two primary care practices. Primary care attendees represented members of the general population of Ireland. An interviewer-administered questionnaire was used to gather data on respondents' awareness of brain complications of diabetes and modifiable risk factors for dementia...
April 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29652531/adult-narratives-of-the-psychosocial-impact-of-cleft-in-a-western-australian-cohort
#5
Wendy Nicholls, Martin Persson, Suzanne Robinson, Linda Selvey
BACKGROUND: Living with a cleft condition involves many years of multidisciplinary therapy, treatment, and surgical intervention. This complex process may have both physical and psychosocial long-term impacts. There is limited evidence of the psychosocial impact of cleft on individuals in Australia. AIM: To obtain an understanding of the adult patient perception of having a cleft and explore the impact of the condition on their lives. DESIGN: Qualitative methodologies at one case study site in Western Australia...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29652468/changes-in-cementation-of-reef-building-oysters-transitioning-from-larvae-to-adults
#6
Andrés M Tibabuzo Perdomo, Erik M Alberts, Stephen D Taylor, Debra M Sherman, Chia-Ping Huang, Jonathan J Wilker
Oysters construct extensive reef communities, providing food, protection from storms, and healthy coastlines. We still do not have a clear picture of how these animals attach to surfaces. Efforts described herein provide the first examination of adhesion at the transition from free swimming larvae to initial substrate attachment, through meta- morphosis, and on to adulthood. Two different bonding systems were found to coexist. Larvae use an organic, hydrated glue that persists while the animal progresses into the juvenile phase, at which point a very different adhesive emerges...
April 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29652167/computational-phantoms-icrp-icru-and-further-developments
#7
M Zankl, J Becker, C Lee, W E Bolch, Y S Yeom, C H Kim
Phantoms simulating the human body play a central role in radiation dosimetry. The first computational body phantoms were based upon mathematical expressions describing idealised body organs. With the advent of more powerful computers in the 1980s, voxel phantoms have been developed. Being based on three-dimensional images of individuals, they offer a more realistic anatomy. Hence, the International Commission on Radiological Protection (ICRP) decided to construct voxel phantoms representative of the adult Reference Male and Reference Female for the update of organ dose coefficients...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29652045/-the-medical-recreational-and-balneotherapeutic-regions-of-the-krasnoyarsk-territory
#8
N K Dzhabarova, N G Sidorina, I N Smirnova, A A Kokhanenko, N G Klopotova
BACKGROUND: the creation of the efficient system of the spa and health resort-based health care for the population of the entire territory of the Russian Federation requires the systematic evaluation and protection of the natural resources of country as a basis for the further development of the health resort and recreation facilities in different regions. AIM: The objective of the present study was to estimate the possibilities of expansion of the health resort and recreational activities based on the rational exploitation of the natural resources of the medical-recreational and balneotherapeutic areas of the Krasnoyarsk Territory...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29651869/new-mesh-type-phantoms-and-their-dosimetric-applications-including-emergencies
#9
C H Kim, Y S Yeom, T T Nguyen, M C Han, C Choi, H Lee, H Han, B Shin, J-K Lee, H S Kim, M Zankl, N Petoussi-Henss, W E Bolch, C Lee, B S Chung, R Qiu, K Eckerman
Committee 2 of the International Commission on Radiological Protection (ICRP) has constructed mesh-type adult reference computational phantoms by converting the voxel-type ICRP Publication 110 adult reference computational phantoms to a high-quality mesh format, and adding those tissues that were below the image resolution of the voxel phantoms and therefore not included in the Publication 110 phantoms. The new mesh phantoms include all the necessary source and target tissues for effective dose calculations, including the 8-40-µm-thick target layers of the alimentary and respiratory tract organs, thereby obviating the need for supplemental organ-specific stylised models (e...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29651868/the-mandate-and-work-of-icrp-committee-2-on-doses-from-radiation-exposure
#10
J D Harrison
The practical implementation of the International Commission on Radiological Protection's (ICRP) system of radiological protection requires the availability of appropriate methodology and data. Over many years, ICRP Committee 2 has provided sets of dose coefficients to allow users to evaluate equivalent and effective doses for radiation exposures of workers and members of the public. The methodology being applied in the calculation of doses is state-of-the-art in terms of the biokinetic models used to describe the behaviour of inhaled and ingested radionuclides, and the dosimetric models used to model radiation transport for external and internal exposures...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29651820/seroprevalence-of-opsonophagocytic-antibodies-against-serotype-ia-ib-ii-iii-and-v-group-b-streptococcus-among-korean-population
#11
Ji Hyen Lee, Han Wool Kim, Kyung Hyo Kim
BACKGROUND: Invasive Streptococcus agalactiae (group B streptococcus, GBS) infection most commonly occurs in infants; however, cases of GBS infection in adults, particularly in the elderly with significant underlying diseases, are being increasingly reported. We analyzed the serotype specific opsonophagocytic antibodies (the major mechanism of protection against GBS) in infants, adults, and the elderly. METHODS: The opsonization indices (OIs) of antibodies against serotype Ia, Ib, II, III, and V GBS were studied in 89 infants, 35 adults (age, 30-50 years), and 62 elderly individuals (age, 65-85 years) according to the University of Alabama at Birmingham GBS opsonophagocytic killing assay protocol (www...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29651724/serum-folate-and-cobalamin-levels-and-urinary-dimethylarsinic-acid-in-us-children-and-adults
#12
Jianmin Zhu, Yanhui Gao, Dianjun Sun, Yudan Wei
Nutritional status could affect arsenic metabolism and toxicity in the general population chronically exposed to low levels of inorganic arsenic. In this study, we examined the association of serum folate and cobalamin with urinary concentrations of dimethylarsinic acid (DMA), the most abundant metabolite of inorganic arsenic measured in urine, in children and adults who participated in the 2003-2006 US National Health and Nutrition Examination Surveys. A total of 1161 children (aged 6-19 years) and 1938 adults (aged 20-85 years) were analyzed for the association using multivariate general linear models, adjusting for potential confounders...
April 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29650747/patient-centred-primary-care-of-adults-with-severe-and-profound-intellectual-and-developmental-disabilities-patient-caregiver-physician-relationship
#13
Katherine Stringer, Amanda L Terry, Bridget L Ryan, Andrea Pike
OBJECTIVE: To explore the process of the development of the patient-physician relationship in adult patients with severe or profound intellectual and developmental disabilities (IDD), from the perspective of the patients' caregivers. DESIGN: Constructivist grounded theory. SETTING: St John's, NL. PARTICIPANTS: Thirteen primary caregivers (5 males, 8 females) of 1 or more adults with severe or profound IDD. METHODS: Data were collected via in-depth, semistructured interviews conducted in person or by telephone...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29649819/patent-foramen-ovale-and-cryptogenic-stroke-or-transient-ischemic-attack-to-close-or-not-to-close-a-systematic-review-and-meta-analysis
#14
Simona Lattanzi, Francesco Brigo, Claudia Cagnetti, Mario Di Napoli, Mauro Silvestrini
BACKGROUND: The optimal strategy of secondary stroke prevention in patients with patent foramen ovale (PFO) is controversial. This study was performed to evaluate the efficacy and safety of the device closure (DC) versus the medical therapy (MT) in patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO. SUMMARY: Randomized controlled trials with active and control groups receiving the DC plus MT and MT alone in patients with history of cryptogenic stroke/TIA and diagnosis of PFO were systematically searched...
April 12, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29649621/astrocyte-specific-dj-1-overexpression-protects-against-rotenone-induced-neurotoxicity-in-a-rat-model-of-parkinson-s-disease
#15
Briana R De Miranda, Emily M Rocha, Qing Bai, Amina El Ayadi, David Hinkle, Edward A Burton, J Timothy Greenamyre
DJ-1 is a redox-sensitive protein with several putative functions important in mitochondrial physiology, protein transcription, proteasome regulation, and chaperone activity. High levels of DJ-1 immunoreactivity are reported in astrocytes surrounding pathology associated with idiopathic Parkinson's disease, possibly reflecting the glial response to oxidative damage. Previous studies showed that astrocytic over-expression of DJ-1 in vitro prevented oxidative stress and mitochondrial dysfunction in primary neurons...
April 9, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29649337/leg-length-skull-circumference-and-the-incidence-of-dementia-in-latin-america-and-china-a-10-66-population-based-cohort-study
#16
Martin J Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, Ivonne Z Jimenez-Velazquez, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Michael E Dewey, Maelenn M Guerchet, Zhaorui Liu, Jorge J Llibre Guerra, A Matthew Prina
BACKGROUND: Adult leg length is influenced by nutrition in the first few years of life. Adult head circumference is an indicator of brain growth. Cross-sectional studies indicate inverse associations with dementia risk, but there have been few prospective studies. METHODS: Population-based cohort studies in urban sites in Cuba, Dominican Republic Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China. Sociodemographic and risk factor questionnaires were administered to all participants, and anthropometric measures taken, with ascertainment of incident dementia, and mortality, three to five years later...
2018: PloS One
https://www.readbyqxmd.com/read/29649262/antinociceptive-antibiotics-loaded-into-solid-lipid-nanoparticles-of-prolonged-release-measuring-pharmacological-efficiency-and-time-span-on-chronic-monoarthritis-rats
#17
Carlos Valdes, Gonzalo Bustos, Jose L Martinez, Claudio Laurido
Pain is a sensory experience of a complex physiological nature in which is not only involved the nervous system. Among its many features is the development of chronic pain that is more complicated to treat because of the central somatization processes involved, becoming inefficient treatments used in other forms of pain. Among them is the role of glial cells, whose participation is such that some authors have proposed to chronic pain as a gliopathy. Because of this, the drug target of possible treatments focuses on modulating nociceptive response affecting transduction into the central nervous system through affecting synapses in the dorsal horn of the spinal cord...
2018: PloS One
https://www.readbyqxmd.com/read/29648613/trending-on-pinterest-an-examination-of-pins-about-skin-tanning
#18
Smita C Banerjee, Vivian M Rodríguez, Kathryn Greene, Jennifer L Hay
Rates of melanoma and nonmelanoma skin cancers are on the rise in the USA with data revealing disproportionate increase in female young adults. The popularity of intentional skin tanning among U.S. adolescents is attributed to several factors, including prioritization of physical appearance, media images of tanned celebrities, ease of availability of artificial tanning facilities, and more recently, the prevalence and celebration of tanned skin on social media. Pinterest, as the third most popular social media platform, was searched for "pins" about skin tanning...
April 10, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29648514/beneficial-impacts-of-regular-exercise-on-platelet-function-in-sedentary-older-adults-evidence-from-a-randomized-6-month-walking-trial
#19
Andrew Haynes, Matthew D Linden, Elisa Robey, Louise H Naylor, Philip N Ainslie, Kay L Cox, Nicola T Lautenschlager, Daniel J Green
Platelet activation, including the formation of monocyte platelet aggregates (MPAs), contributes to atherosclerosis, thrombus formation and acute coronary syndromes. Regular participation in exercise can lower cardiovascular risk, but little is known regarding the impact of exercise training on platelet function. We investigated the effect of 6 months of walking exercise on platelet function in sedentary older adults without significant cardiovascular disease. Twenty-seven participants were randomly allocated to 6 months of either: no-exercise (n=13) or 3 x 50 mins/wk of supervised centre-based walking (n=14)...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29645351/a-proteomics-approach-to-identify-candidate-proteins-secreted-by-m%C3%A3-ller-glia-that-protect-ganglion-cells-in-the-retina
#20
Noelia Ruzafa, Xandra Pereiro, Marlen F Lepper, Stefanie M Hauck, Elena Vecino
The retinal Müller glial cells, like other types of glial cells, can enhance the survival and activity of neurons, especially of retinal ganglion cells (RGCs), which are the neurons affected in diseases such as glaucoma, diabetes and retinal ischemia. It has been demonstrated that Müller glia release neurotrophic factors that support RGC survival, yet many of these factors remain to be elucidated. To define these neurotrophic factors, we adopted a quantitative proteomic approach aiming at identifying neuroprotective proteins...
April 12, 2018: Proteomics
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