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https://www.readbyqxmd.com/read/29454029/sex-related-differences-in-the-association-between-grip-strength-and-depression-results-from-the-irish-longitudinal-study-on-ageing
#1
Cillian P McDowell, Brett R Gordon, Matthew P Herring
Muscular strength is a modifiable protective factor for mental health across aging populations. Evidence of sex-related differences in its associations with mental health is limited. Therefore, the purpose of this study was to examine sex-related differences in cross-sectional and prospective associations between grip strength and depressive symptoms and status. Participants were community dwelling adults (N = 4505; 56.5% female), aged ≥50 years. As a measure of muscular strength, grip strength (kg) of the dominant hand was assessed using a hand-held dynamometer at baseline...
February 14, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29453818/the-association-between-thyroid-function-and-incidence-of-metabolic-syndrome-in-euthyroid-subjects-tianjin-chronic-low-grade-systemic-inflammation-and-health-cohort-study
#2
Yeqing Gu, Yanyan Wang, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Honglei Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
OBJECTIVE: Thyroid hormones (THs) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed the association between THs and metabolic syndrome (MetS) in a general population. We therefore designed a cohort study to examine whether serum THs levels within the reference range are predictive factors for developing MetS in adults. DESIGN: Prospective cohort study. PARTICIPANTS: A prospective study (n=6,119) was performed in Tianjin, China...
February 17, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29453804/probiotics-affect-one-carbon-metabolites-and-catecholamines-in-a-genetic-rat-model-of-depression
#3
Sandra Tillmann, Hussain M Awwad, Amanda R Eskelund, Giulia Treccani, Juergen Geisel, Gregers Wegener, Rima Obeid
SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior. METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (10 9 or 10 10 colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues...
February 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29452194/decompressive-craniectomy-protects-against-hippocampal-edema-and-behavioral-deficits-at-an-early-stage-of-a-moderately-controlled-cortical-impact-brain-injury-model-in-adult-male-rats
#4
Zonggang Hou, Runfa Tian, Feifei Han, Shuyu Hao, Weichuan Wu, Xiang Mao, Xiaogang Tao, Te Lu, Jinqian Dong, Yun Zhen, Baiyun Liu
A decompressive craniectomy (DC) has been shown to be a life-saving therapeutic treatment for traumatic brain injury (TBI) patients, which also might result in post-operative behavioral dysfunction. However, there is still no definite conclusion about whether the behavioral dysfunction already existed at an early stage after the DC operation or is just a long-term post-operation complication. Therefore, the aim of the present study was to analyze whether DC treatment was beneficial to behavioral function at an early stage post TBI...
February 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29451372/morphological-spectra-of-adult-human-stellate-ganglia-implications-for-thoracic-sympathetic-denervation
#5
Oh Jin Kwon, Shrita Pendekanti, Jacob N Fox, Jane Yanagawa, Michael C Fishbein, Kalyanam Shivkumar, H Wayne Lambert, Olujimi Ajijola
BACKGROUND: Cardiac sympathetic denervation (CSD) to treat ventricular arrhythmias (VAs) requires transection at the middle or lower third of stellate (cervicothoracic) ganglia (SG). However, the morphological appearance of the adult SG and distribution of neuronal somata within it are not well described. OBJECTIVE: To determine the morphology of left and right SG (LSG and RSG) and the distribution of somata within. METHODS: LSG and RSG (n=28) from 14 embalmed adult cadavers were dissected intact...
February 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29451354/are-we-underestimating-the-quality-of-aviremic-hepatitis-c-positive-kidneys-time-to-reconsider
#6
L Sibulesky, C E Kling, C Blosser, C K Johnson, A P Limaye, R Bakthavatsalam, N Leca, J D Perkins
KDRI introduced in 2009 included Hepatitis C serologic but not viremic status of the donors. With NAT testing now being mandatory, further evaluation of these donors is possible. We conducted a retrospective matched case-control analysis of adult deceased donor kidney transplants performed between 12/5/2014 to 12/31/2016 with the KDRI score and HCV Ab and NAT testing status obtained from UNOS database. The 205 aviremic Hep C Ab+ NAT - kidney transplants were compared to KDRI matched control kidneys that were Hep C Ab-NAT-...
February 16, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29451296/investigation-of-the-urinary-metabolic-variations-and-the-application-in-bladder-cancer-biomarker-discovery
#7
Xiaoyan Liu, Xiangming Cheng, Xiang Liu, Lu He, Wenli Zhang, Yajie Wang, Wei Sun, Zhigang Ji
Urine metabolomics have been used to identify biomarkers for clinical diseases. However, inter-individual variations and effect factors need to be further evaluated. In the present study, we explored the urine metabolome in a cohort of 203 health adults, 6 patients with benign bladder lesions, and 53 patients with bladder cancer (BCa) using liquid chromatography coupled with high resolution mass spectrometry. Inter-individual analysis of both healthy controls and bladder cancer patients showed that the urine metabolome was relatively stable...
February 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29451035/revisiting-the-physiological-effects-of-methylene-blue-as-a-treatment-of-cyanide-intoxication
#8
Philippe Haouzi, Maxime Gueguinou, Takashi Sonobe, Annick Judenherc-Haouzi, Nicole Tubbs, Mohamed Trebak, Joseph Cheung, Frederic Bouillaud
BACKGROUND: Although methylene blue (MB) had long been proposed to counteract the effects of cyanide (CN) intoxication, research on its mechanisms of action and efficacy has been abandoned for decades. Recent studies on the benefits of MB in post-anoxic injuries have prompted us to reexamine the relevance of this historical observation. METHODS: Our study was performed in adult male Sprague-Dawley rats and on HEK293T epithelial cells. First, the effects and toxicity of MB (0-80 mg/kg) on circulation and metabolism were established in four urethane-anesthetized rats...
February 16, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29450933/face-cooling-reveals-a-relative-inability-to-increase-cardiac-parasympathetic-activation-during-passive-heat-stress
#9
Zachary J Schlader, Morgan C O'Leary, James R Sackett, Blair D Johnson
We tested the hypothesis that passive heat stress attenuates the increase in cardiac parasympathetic stimulation, vascular resistance, and blood pressure evoked by face cooling. During normothermia and when intestinal temperature was elevated by 1.0 ± 0.2°C, eleven healthy young adults underwent 3 min of face cooling. Face cooling was accomplished by placing a 2.5 L bag of ice water (0 ± 0°C) over the cheeks, eyes, and forehead. Primary variables included forehead skin temperature, mean arterial pressure, and systemic, forearm and cutaneous vascular resistances...
February 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29450895/a-test-of-multi-session-automatic-action-tendency-retraining-to-reduce-alcohol-consumption-among-young-adults-in-the-context-of-a-human-laboratory-paradigm
#10
Robert F Leeman, Christine Nogueira, Reinout W Wiers, Janna Cousijn, Kelly Serafini, Kelly S DeMartini, John A Bargh, Stephanie S O'Malley
BACKGROUND: Young adult heavy drinking is an important public health concern. Current interventions have efficacy but with only modest effects, thus novel interventions are needed. In prior studies, heavy drinkers, including young adults, have demonstrated stronger automatically triggered approach tendencies to alcohol-related stimuli than lighter drinkers. Automatic action tendency retraining has been developed to correct this tendency and consequently reduce alcohol consumption. The current study is the first to test multiple iterations of automatic action tendency retraining, followed by laboratory alcohol self-administration...
February 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29450888/spatiotemporal-heterogeneity-in-prey-abundance-and-vulnerability-shapes-the-foraging-tactics-of-an-omnivore
#11
Nathaniel D Rayl, Guillaume Bastille-Rousseau, John F Organ, Matthew A Mumma, Shane P Mahoney, Colleen E Soulliere, Keith P Lewis, Robert D Otto, Dennis L Murray, Lisette P Waits, Todd K Fuller
1.Prey abundance and prey vulnerability vary across space and time, but we know little about how they mediate predator-prey interactions and predator foraging tactics. To evaluate the interplay between prey abundance, prey vulnerability, and predator space use, we examined patterns of black bear (Ursus americanus) predation of caribou (Rangifer tarandus) neonates in Newfoundland, Canada using data from 317 collared individuals (9 bears, 34 adult female caribou, 274 caribou calves). 2.During the caribou calving season, we predicted that landscape features would influence calf vulnerability to bear predation, and that bears would actively hunt calves by selecting areas associated with increased calf vulnerability...
February 16, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29450697/endogenous-sex-steroids-dampen-neuroinflammation-and-improve-outcome-of-traumatic-brain-injury-in-mice
#12
Amy C Clevenger, Hoon Kim, Ernesto Salcedo, Joan C Yonchek, Krista M Rodgers, James E Orfila, Robert M Dietz, Nidia Quillinan, Richard J Traystman, Paco S Herson
The role of biological sex in short-term and long-term outcome after traumatic brain injury (TBI) remains controversial. The observation that exogenous female sex steroids (progesterone and estrogen) reduce brain injury coupled with a small number of clinical studies showing smaller injury in women suggest that sex steroids may play a role in outcome from TBI. We used the controlled cortical impact (CCI) model of TBI in mice to test the hypothesis that after CCI, female mice would demonstrate less injury than male mice, related to the protective role of endogenous steroids...
February 15, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29450621/ngf-protects-corneal-retinal-and-cutaneous-tissues-cells-from-phototoxic-effect-of-uv-exposure
#13
Maria Luisa Rocco, Bijorn Omar Balzamino, Luigi Aloe, Alessandra Micera
PURPOSE: Based on evidence that nerve growth factor (NGF) exerts healing action on damaged corneal, retinal, and cutaneous tissues, the present study sought to assess whether topical NGF application can prevent and/or protect epithelial cells from deleterious effects of ultraviolet (UV) radiation. METHODS: Eyes from 40 young-adult Sprague Dawley rats and cutaneous tissues from 36 adult nude mice were exposed to UVA/B lamp for 60 min, either alone or in the presence of murine NGF...
February 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29450244/characteristics-of-adherence-to-methadone-maintenance-treatment-over-a-15-year-period-among-homeless-adults-experiencing-mental-illness
#14
Milad Parpouchi, Akm Moniruzzaman, Stefanie N Rezansoff, Angela Russolillo, Julian M Somers
Background: Methadone maintenance treatment (MMT) has important protective effects related to reduced illicit opioid use, infectious disease transmission, and overdose mortality. Adherence to MMT has not been examined among homeless people. We measured MMT adherence and reported relevant characteristics among homeless adults experiencing mental illness in Vancouver, British Columbia, Canada. Material and methods: Homeless adults living with mental illness who had received MMT prior to the baseline interview of the Vancouver At Home study ( n = 78) were included in analyses...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450214/-mycobacterium-abscessus-complex-infections-a-retrospective-cohort-study
#15
Maroun Sfeir, Marissa Walsh, Rossana Rosa, Laura Aragon, Sze Yan Liu, Timothy Cleary, Marylee Worley, Corey Frederick, Lilian M Abbo
Background: Infections caused by Mycobacterium abscessus group strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. We describe the risk factors, treatment, and clinical outcomes of patients in 2 large academic medical centers in the United States. Methods: A retrospective cohort study of hospitalized adults with a positive culture for M. abscessus in Miami, Florida (January 1, 2011, to December 31, 2014). Demographics, comorbidities, the source of infection, antimicrobial susceptibilities, and clinical outcomes were analyzed...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29450198/parvovirus-b19-what-is-the-relevance-in-transfusion-medicine
#16
REVIEW
David Juhl, Holger Hennig
Parvovirus B19 (B19V) has been discovered in 1975. The association with a disease was unclear in the first time after the discovery of B19V, but meanwhile, the usually droplet transmitted B19V is known as the infectious agent of the "fifth disease," a rather harmless children's illness. But B19V infects erythrocyte progenitor cells and thus, acute B19V infection in patients with a high erythrocyte turnover may lead to a life-threatening aplastic crisis, and acutely infected pregnant women can transmit B19V to their unborn child, resulting in a hydrops fetalis and fetal death...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29446860/development-of-a-clinical-prediction-rule-for-tuberculous-meningitis-in-adults-in-lima-peru
#17
Lely Solari, Alonso Soto, Patrick van der Stuyft
OBJECTIVES: Diagnosis of Tuberculous Meningitis (TM) is a challenge in countries with a high burden of the disease and constrained resources and Clinical Prediction Rules (CPRs) could be of assistance. We aimed at developing a CPR for diagnosis of TM in a Latin American setting with high tuberculosis incidence and a concentrated HIV epidemic. METHODS: We enrolled adult patients with clinical suspicion of TM attending two hospitals in Lima, Peru. We obtained information on potential anamnestic, clinical and laboratory predictive findings that are easy to collect and promptly available...
February 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29446833/body-fat-content-fat-distribution-and-adipocytokine-production-and-their-correlation-with-fertility-markers-in-young-adult-men-and-women-conceived-by-icsi
#18
F Belva, J De Schepper, M Roelants, H Tournaye, M Bonduelle, S Provyn
OBJECTIVE: Differences in body fat content during childhood and adolescence have been described in offspring conceived by In Vitro Fertilisation (IVF) and Intracytoplasmic Sperm Injection (ICSI). However, data on body fat and its distribution as well as on adipocytokine production in young adults conceived by ICSI are non-existent. We investigated if young adult men and women conceived by ICSI have a normal body fat patterning and adipocytokine production. DESIGN: Cohort study...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29446829/injection-testosterone-and-adverse-cardiovascular-events-a-case-crossover-analysis
#19
J Bradley Layton, Dongmei Li, Christoph R Meier, Julie L Sharpless, Til Stürmer, M Alan Brookhart
CONTEXT: Exogenous testosterone administration may affect blood clotting, polycythemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short-term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms. OBJECTIVE: We sought to evaluate the short-term cardiovascular risk of receiving injection testosterone...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29446484/head-position-affects-the-direction-of-occlusal-force-during-tapping-movement
#20
Kazutoshi Nakamura, Ichiro Minami, Junichiro Wada, Yasuha Ikawa, Noriyuki Wakabayashi
BACKGROUND: Despite numerous reports describing the relationship between head position and mandibular movement in human subjects, the direction and magnitude of force at the occlusal contacts have not been investigated in relation to head position. OBJECTIVE: To investigate the effect of head position on the direction of occlusal force while subjects performed a tapping movement. METHODS: Twenty-three healthy adult subjects were asked to sit on a chair with their back upright and to perform 15 tapping movements in five different head positions: natural head position (control); forward; backward; and right and left rolled...
February 15, 2018: Journal of Oral Rehabilitation
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