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https://www.readbyqxmd.com/read/29054048/synthesis-and-characterization-of-incorporating-mussel-mimetic-moieties-into-photoactive-hydrogel-adhesive
#1
Zhiwen Zeng, Hongsheng Wang, Yosry Morsi, Xiumei Mo
Surgical adhesive is the optimal candidate for the replacement of traditional mechanical wound closure. In our paper, mussel adhesive proteins inspired hydrogel adhesive was prepared with 3, 4-dihydroxyphyenylanine acrylamide (DOPA-AA), poly (ethylene glycol) diacrylate (PEGDAA) and thiolated chitosan (CSS) by UV irradiation. DOPA-AA, containing catechol group and vinyl group, was successful synthesized and characterized by FTIR and (1)HNMR. The gelation time, equilibrium water content, degradation, materials properties and adhesive strength of the hydrogels were studied...
October 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29052668/mussel-mimetic-hydrogels-with-defined-cross-linkers-achieved-via-controlled-catechol-dimerization-exhibiting-tough-adhesion-for-wet-biological-tissues
#2
Pengchao Zhao, Kongchang Wei, Qian Feng, Heng Chen, Dexter Siu Hong Wong, Xiaoyu Chen, Chia-Ching Wu, Liming Bian
The engineering of catechol-based hydrogels to bind to wet biological tissues with high adhesion energy remains a challenge. Herein, fast quinone-nucleophile coupling and dynamic boronate ester bond were used to enhance the interfacial adhesion and bulk cohesion of our dual-crosslinked hydrogels, respectively, for fabricating mussel-mimetic tough adhesives.
October 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29051323/epithelial-to-mesenchymal-transition-antagonizes-response-to-targeted-therapies-in-lung-cancer-by-suppressing-bim
#3
Anthony C Faber, Kyung-A Song, Matthew J Niederst, Timothy L Lochmann, Aaron N Hata, Hidenori Kitai, Jungoh Ham, Konstantinos V Floros, Mark A Hicks, Haichuan Hu, Hillary E Mulvey, Yotam Drier, Daniel A R Heisey, Mark T Hughes, Neha U Patel, Elizabeth Lockerman, Angel R Garcia, Shawn Gillepsie, Hannah L Archibald, Maria Gomez-Caraballo, Tara J Nulton, Brad Windle, Zofia Piotrowska, Sinem E Sahingur, Shirley M Taylor, Mikhail G Dozmorov, Lecia V Sequist, Bradley E Bernstein, Hiromichi Ebi, Jeffrey A Engelman
PURPOSE: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. EXPERIMENTAL DESIGN: We have developed several models of EMT-mediated resistance to EGFR inhibitors (EGFRi) in EGFR mutant lung cancers to evaluate a novel mechanism of EMT-mediated resistance. Results: We observed that mesenchymal EGFR mutant lung cancers are resistant to EGFRi-induced apoptosis via insufficient expression of BIM, preventing cell death despite potent suppression of oncogenic signaling following EGFRi treatment...
October 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29046894/fatty-acid-mimetic-micelles-for-dual-delivery-of-antigens-and-imidazoquinoline-adjuvants
#4
Sema Sevimli, Frances C Knight, Pavlo Gilchuk, Sebastian Joyce, John T Wilson
Vaccine design has undergone a shift towards the use of purified protein subunit vaccines, which offer increased safety and greater control over antigen specificity, but at the expense of immunogenicity. Here we report the development of a new polymer-based vaccine delivery platform engineered to enhance immunity through the co-delivery of protein antigens and the Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ). Owing to the preferential solubility of IMQ in fatty acids, a series of block copolymer micelles with a fatty acid-mimetic core comprising lauryl methacrylate (LMA) and methacrylic acid (MAA), and a poly(ethylene glycol) methyl ether methacrylate (PEGMA) corona decorated with pyridyl disulfide ethyl methacrylate (PDSM) moieties for antigen conjugation were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29044869/polyproline-is-a-minimal-antifreeze-protein-mimetic-and-enhances-the-cryopreservation-of-cell-monolayers
#5
Ben Graham, Trisha L Bailey, Joseph R J Healey, Moreno Marcellini, Sylvain Deville, Matthew I Gibson
Tissue engineering, gene therapy, drug screening and emerging regenerative medicine therapies are fundamentally reliant on high-quality adherent cell culture, but current methods to cryopreserve cells in this format can give low cell yields and requires large volumes of solvent 'antifreezes'. Herein we report polyproline is a minimum (bio)synthetic mimic of antifreeze proteins, which is accessible by solution, solid phase and recombinant methods. We demonstrate that polyproline has ice recrystallization inhibition activity linked to its amphipathic helix and that it enhances the DMSO- cryopreservation of adherent cell lines...
October 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29043304/a-single-stranded-fluorescent-peptide-probe-for-targeting-collagen-in-connective-tissues
#6
Xiangdong Cai, Zhao Liu, Sha Zhao, Chen Song, Shouliang Dong, Jianxi Xiao
We herein report the construction of a novel single stranded fluorescent collagen mimetic peptide by introducing a bulky FAM dye in the central region rather than the N terminus. Without the need for any prior thermal or ultraviolet treatment, the peptide probe can be conveniently applied to specifically target collagen in connective tissues for fluorescence imaging.
October 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29042166/radiolabeling-and-preliminary-biodistribution-study-of-99m-tc-labeled-antibody-mimetic-scaffold-protein-repebody-for-initial-clearance-properties
#7
Sajid Mushtaq, Jong Kook Rho, Jung Ae Kang, Joong-Jae Lee, Jung Young Kim, You Ree Nam, Seong-Jae Yun, Gyeong Hee Lee, Sang Hyun Park, Dong-Eun Lee, Hak-Sung Kim
Antibody-mimetic proteins are intensively being developed for biomedical applications including tumor imaging and therapy. Among them, repebody is a new class of protein that consists of highly diverse leucine-rich repeat (LRR) modules. Although all possible biomedical applications with repebody are ongoing, it's in vivo biodistribution and excretion pathway has not yet been explored. In this study, hexahistidine (His6)-tag bearing repebody (rEgH9) was labeled with [(99m)Tc]-tricarbonyl, and biodistribution was performed following intravenous (I...
September 25, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29033843/commentary-the-apolipoprotein-a-i-mimetic-peptide-d-4f-restrains-neointimal-formation-through-heme-oxygenase-1-up-regulation
#8
COMMENT
Giovanni Li Volti, Roberto Avola, Daniele Tibullo
No abstract text is available yet for this article.
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29031228/peptide-based-electrochemical-biosensor-for-juvenile-idiopathic-arthritis-detection
#9
V R Rodovalho, G R Araujo, E R Vaz, C Ueira-Vieira, L R Goulart, J M Madurro, A G Brito-Madurro
Juvenile idiopathic arthritis (JIA) is a wide group of diseases, characterized by synovial inflammation and joint tissue damage. Due to the delay in the implementation of biomarkers into clinical practice and the association with severe sequels, there is an imperative need for new JIA diagnosis strategies. Electrochemical biosensors based on screen-printed electrodes and peptides are promising alternatives for molecular diagnosis. In this work, a novel biosensor for detecting juvenile idiopathic arthritis (JIA) was developed based on the immobilization of the PRF+1 mimetic peptide, as recognition biological element, on the surface of screen-printed carbon electrode...
October 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29030555/highly-compressed-water-structure-observed-in-a-perchlorate-aqueous-solution
#10
Samuel Lenton, Natasha H Rhys, James J Towey, Alan K Soper, Lorna Dougan
The discovery by the Phoenix Lander of calcium and magnesium perchlorates in Martian soil samples has fueled much speculation that flows of perchlorate brines might be the cause of the observed channeling and weathering in the surface. Here, we study the structure of a mimetic of Martian water, magnesium perchlorate aqueous solution at its eutectic composition, using neutron diffraction in combination with hydrogen isotope labeling and empirical potential structure refinement. We find that the tetrahedral structure of water is heavily perturbed, the effect being equivalent to pressurizing pure water to pressures of order 2 GPa or more...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29030428/a-retractable-lid-in-lecithin-cholesterol-acyltransferase-provides-a-structural-mechanism-for-activation-by-apolipoprotein-a-i
#11
Kelly A Manthei, Joomi Ahn, Alisa Glukhova, Wenmin Yuan, Christopher Larkin, Taylor D Manett, Louise Chang, James A Shayman, Milton J Axley, Anna Schwendeman, John J G Tesmer
Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the maturation of high density lipoproteins (HDL) from discoidal to spherical particles. LCAT is activated through an unknown mechanism by apolipoprotein A-I (ApoA-I) and other mimetic peptides that form a belt around HDL. Here we report the crystal structure of LCAT with an extended lid that blocks access to the active site, consistent with an inactive conformation...
October 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29029466/a-comparative-study-of-anti-aging-properties-and-mechanism-resveratrol-and-caloric-restriction
#12
Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen, Gang Chen
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027317/exposure-to-omentum-adipose-tissue-conditioned-medium-from-obese-pregnant-women-promotes-myometrial-artery-dysfunction
#13
Christina E Hayward, Elizabeth J Cowley, Colin P Sibley, Jenny E Myers, Mark Wareing
AIM: Underlying mechanisms of poor pregnancy outcome in obese (OB) mothers (body mass index [BMI] ≥ 30 kg/m(2) ) are unknown. Our studies demonstrate that OB pregnant women have altered myometrial artery (MA) function related to the thromboxane and nitric oxide pathways. In obesity, increased central fat mass is associated with an altered endocrine milieu. We tested the hypothesis that in OB pregnant women the omentum, a central fat store, releases factors that promote dysfunction in normal MAs...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29024661/paclitaxel-reduces-axonal-bclw-to-initiate-ip3r1-dependent-axon-degeneration
#14
Sarah E Pease-Raissi, Maria F Pazyra-Murphy, Yihang Li, Franziska Wachter, Yusuke Fukuda, Sara J Fenstermacher, Lauren A Barclay, Gregory H Bird, Loren D Walensky, Rosalind A Segal
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons required for transmission of sensory information; axonal degeneration causes impaired tactile sensation and persistent pain. Currently the molecular mechanisms of CIPN are not understood, and there are no available treatments. Here we show that the chemotherapeutic agent paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellular calcium flux, and activating calcium-dependent calpain proteases...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29024217/use-of-the-target-of-rapamycin-fatc-domain-as-a-general-membrane-anchor-the-fkbp-12-like-domain-of-fkbp38-as-a-case-study
#15
Maristella De Cicco, Lech-G Milroy, Sonja A Dames
Increased efforts have been undertaken to better understand the formation of signaling complexes at cellular membranes. Since the preparation of proteins containing a transmembrane domain or a prenylation motif is generally challenging an alternative membrane anchoring unit that is easy to attach, water-soluble and binds to different membrane mimetics would find broad application. The 33-residue long FATC domain of yeast TOR1 (y1fatc) fulfills these criteria and binds to neutral and negatively charged micelles, bicelles and liposomes...
October 12, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29024172/benzyl-mono-p-fluorophosphonate-and-benzyl-penta-p-fluorophosphate-anions-are-physiologically-stable-phosphotyrosine-mimetics-and-inhibitors-of-protein-tyrosine-phosphatases
#16
Stefan Wagner, Matteo Accorsi, Jörg Rademann
α,α-Difluoro-benzyl phosphonates are currently the most popular class of phosphotyrosine mimetics. Structurally derived from the natural substrate phosphotyrosine, they constitute classical bioisosteres and have enabled the development of potent inhibitors of protein tyrosine phosphatases (PTP) and phosphotyrosine recognition sites such as SH2 domains. Being dianions bearing two negative charges, phosphonates, however, do not permeate membranes and thus are often inactive in cells and have not been a successful starting point toward therapeutics, yet...
October 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29022998/synthesis-characterization-and-antimicrobial-activities-of-copper-derivatives-of-nhc-ii-complexes
#17
Karumutchu Sitalu, B Hari Babu, J Naveena Lavanya Latha, A Lakshmana Rao
BACKGROUND: Caffeine, 1, 3, 7-trimethylxanthine is one of the xanthine derivatives that are for the most part utilized as a part of solutions as diuretics. The Cu (II) complexes have been synthesized from the N-heterocyclic carbene ligands. MATERIALS AND METHODS: The Cu (II) NHC complexes were characterized using analytical and spectral techniques. Antibacterial and antifungal activities of the Cu (II) NHC complexes were determined using the reported techniques...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022898/superoxide-drives-progression-of-parkin-pink1-dependent-mitophagy-following-translocation-of-parkin-to-mitochondria
#18
Bin Xiao, Xiao Deng, Grace G Y Lim, Shaoping Xie, Zhi Dong Zhou, Kah-Leong Lim, Eng-King Tan
Reactive oxygen species (ROS) and mitophagy are profoundly implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Several studies have suggested that ROS are not involved in mitochondrial translocation of Parkin which primes mitochondria for autophagic elimination. However, whether ROS play a role in the execution of mitophagy is unknown. In the present study, we show that carbonyl cyanide m-chlorophenylhydrazone (CCCP) treatment induced both mitochondrial depolarization and generation of ROS that were needed for the mitophagy process...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29021780/chronic-5-aminoimidazole-4-carboxamide-1-%C3%AE-d-ribofuranoside-treatment-induces-phenotypic-changes-in-skeletal-muscle-but-does-not-improve-disease-outcomes-in-the-r6-2-mouse-model-of-huntington-s-disease
#19
Marie-France Paré, Bernard J Jasmin
Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercise mimetics (EMs) are a group of drugs and small molecules that target signaling pathways in skeletal muscle known to be activated by endurance exercise. The EM 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) has been shown to induce cognitive benefits in healthy mice...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29021250/electrostatic-lipid-protein-interactions-sequester-the-curli-amyloid-fold-on-the-lipopolysaccharide-membrane-surface
#20
Hema M Swasthi, Samrat Mukhopadhyay
Curli is a functional amyloid protein in the extracellular matrix of enteric Gram-negative bacteria. Curli is assembled at the cell surface and consists of CsgA, the major subunit of curli, and a membrane-associated nucleator protein, CsgB. Oligomeric intermediates that accumulate during the lag phase of amyloidogenesis are generally toxic, but the underlying mechanism by which bacterial cells overcome this toxicity during curli assembly at the surface remains elusive. Here, we elucidated the mechanism of curli amyloidogenesis and provide molecular insights into the strategy by which bacteria can potentially bypass the detrimental consequences of toxic amyloid intermediates...
October 11, 2017: Journal of Biological Chemistry
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