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Spondyloarthriti

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https://www.readbyqxmd.com/read/28087505/2016-update-of-the-asas-eular-management-recommendations-for-axial-spondyloarthritis
#1
Désirée van der Heijde, Sofia Ramiro, Robert Landewé, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, Floris van Gaalen, Pál Géher, Irene van der Horst-Bruinsma, Robert D Inman, Merryn Jongkees, Uta Kiltz, Tore K Kvien, Pedro M Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compàn, Salih Ozgocmen, Fernando M Pimentel-Santos, John Reveille, Martin Rudwaleit, Jochen Sieper, Percival Sampaio-Barros, Dieter Wiek, Jürgen Braun
To update and integrate the recommendations for ankylosing spondylitis and the recommendations for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA) into one set applicable to the full spectrum of patients with axSpA. Following the latest version of the European League Against Rheumatism (EULAR) Standardised Operating Procedures, two systematic literature reviews first collected the evidence regarding all treatment options (pharmacological and non-pharmacological) that were published since 2009...
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28073957/primary-inefficacy-of-tnf-inhibitors-in-patients-with-axial-spondyloarthritis-a-long-term-follow-up-of-25-patients
#2
Sandra Kossi, Sabrina Dadoun, Guillaume Geri, Aurore Hermet, Bruno Fautrel, Maxime Dougados, Laure Gossec
OBJECTIVES: Primary inefficacy of TNF inhibitors (TNFi) for axial spondyloarthritis (axSpA) is infrequent. The objective of this study was to assess the long-term evolution and final diagnosis of patients with primary inefficacy of TNFi for axSpA. METHODS: This was a systematic retrospective study of all patients receiving a TNFi for axSpA in one tertiary referral centre. Patients had axSpA confirmed by a rheumatologist and were started on a first course of TNFi according to usual practice...
January 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28070627/-tendinopathy-in-rheumatic-diseases
#3
M Henniger, S Rehart
Involvement of tendons and tendon sheaths is frequently found in the most common inflammatory systemic diseases, rheumatoid arthritis and spondyloarthritis. In rheumatoid arthritis tendon manifestations occur as tenosynovitis, with swelling and pain of the tendons mainly on the hands and feet. In spondyloarthritis the involvement of tendons presents as enthesitis with pain and swelling directly at the attachment points of tendons to the bony structures and more commonly in the lower extremities. Pathological alterations of tendons can be normally visualized by sonography and only sometimes with magnetic resonance imaging (MRI) or scintigraphy...
January 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28064208/work-disability-in-non-radiographic-axial-spondyloarthritis-patients-before-and-after-start-of-anti-tnf-therapy-a-population-based-regional-cohort-study-from-southern-sweden
#4
Johan K Wallman, Anna Jöud, Tor Olofsson, Lennart T H Jacobsson, Henning Bliddal, Lars E Kristensen
OBJECTIVE: The aim was to assess work-loss days before and after commencement of anti-TNF treatment in patients with non-radiographic axial spondylarthritis (nr-axSpA). METHODS: Bionaïve nr-axSpA patients (n = 75), aged 17-62 years, fulfilling the Assessment of SpondyloArthritis international Society criteria for axial spondyloarthritis and starting anti-TNF treatment during 2004-11, were retrieved from the observational South Swedish Arthritis Treatment Group study...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28063070/defining-functioning-categories-in-axial-spondyloarthritis-the-role-of-the-asas-health-index
#5
Marco Di Carlo, Valentina Lato, Andrea Di Matteo, Marina Carotti, Fausto Salaffi
The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is an inclusive questionnaire, able to describe the total impairments and restrictions due to axial spondyloarthritis (axSpA). Considering the relationship between ASAS HI and the Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP, the aim of this study is to establish the ASAS HI cut-off values for functioning categories employing the ASDAS-CRP disease activity states in axSpA patients. ASAS HI and ASDAS-CPR were obtained from 140 consecutive axSpA patients, divided in the four ASDAS-CRP disease activity categories...
January 6, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28063066/high-prevalence-of-undiagnosed-axial-spondyloarthritis-in-patients-with-chronic-low-back-pain-consulting-non-rheumatologist-specialists-in-belgium-suspect-study
#6
Laure Tant, Nadine Delmotte, Maria Van den Enden, Valerie Gangji, Herman Mielants
INTRODUCTION: Diagnosis of axial spondyloarthritis (SpA) can be delayed for several years mainly because of low awareness of axial SpA among non-rheumatologists who are the first interlocutors of potential SpA patients. One strategy to decrease the delay between appearance of first symptoms and diagnosis of axial SpA and to allow early management of the disease is to provide the non-rheumatologists with tools to identify patients requiring prompt referral to rheumatologists. This study was designed to evaluate in a real-world setting whether screening patients with chronic low back pain who consult physical medicine and rehabilitation (PMR) physicians, orthopedists, and ophthalmologists is useful in detecting axial SpA...
January 6, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28062405/presence-of-multiple-spondyloarthritis-spa-features-is-important-but-not-sufficient-for-a-diagnosis-of-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#7
Z Ez-Zaitouni, P A C Bakker, M van Lunteren, I J Berg, R Landewé, M van Oosterhout, M Lorenzin, D van der Heijde, F A van Gaalen
OBJECTIVES: Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the Assessment of SpondyloArthritis International Society (ASAS) axSpA criteria is associated with an axSpA diagnosis. METHODS: Baseline data from 500 patients from the SPondyloArthritis Caught Early cohort which includes patients with CBP (≥3 months, ≤2 years, onset <45 years) were analysed...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062378/chronic-bowel-inflammation-and-inflammatory-joint-disease-pathophysiology
#8
Silvia Speca, Laurent Dubuquoy
Bowel inflammation is closely linked to chronic joint inflammation. Research reported in the 1980s demonstrated bowel inflammation with gross and microscopic pathological features identical to those of Crohn's disease in over 60% of patients with spondyloarthritis (SpA). Numerous prospective studies have evidenced joint involvement in patients with chronic inflammatory bowel disease (CIBD) and bowel inflammation in patients with SpA. Nevertheless, the interactions of joint disease and chronic bowel inflammation remain incompletely elucidated...
January 3, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28057210/epigenetic-changes-in-chronic-inflammatory-diseases
#9
O Fogel, C Richard-Miceli, J Tost
The number of people diagnosed with chronic inflammatory diseases has increased noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD), and psoriasis are the most frequent chronic inflammatory diseases, resulting from a combination of genetic predisposition and environmental factors. Epigenetic modifications include DNA methylation, histone modifications, and small and long noncoding RNAs. They are influenced by environmental exposure, life-style, and aging and have recently been shown to be altered in many complex diseases including inflammatory diseases...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28043168/plasma-levels-of-pentraxin-3-in-patients-with-spondyloarthritis
#10
Renato Nisihara, Thelma L Skare, João Otávio Zeni, Henrique Rasera, Karita Lidani, Iara Messias-Reason
CONTEXT: Determining the disease's inflammatory activity in Spondyloarthritis (SpA) is difficult although very important as it is this that drives treatment. OBJECTIVE: To investigate if plasma PTX3 (Pentraxine-3) could act as an inflammatory marker in SpA. METHODS: Eighty one SpA patients (11 with psoriatic arthritis or PsoA and 70 with Ankylosing Spondylitis or AS) and 90 gender and age paired controls were studied for plasma PTX3 levels by ELISA...
January 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28042123/radiographic-evaluation-of-sacroiliac-joints-in-axial-spondyloarthritis-still-worth-performing
#11
EDITORIAL
Denis Poddubnyy
No abstract text is available yet for this article.
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28035438/should-axial-spondyloarthritis-without-radiographic-changes-be-treated-with-anti-tnf-agents
#12
REVIEW
Andrew Keat, Alexander N Bennett, Karl Gaffney, Helena Marzo-Ortega, Raj Sengupta, Tamara Everiss
A spectrum of disease extends beyond the rigid confines of ankylosing spondylitis (AS). Axial spondyloarthritis (axSpA) encompasses non-radiographic axSpA (nr-axSpA) in individuals without established radiographic changes but with other clinical/imaging axSpA features and AS in those with definite sacroiliac joint changes on pelvic X-rays. A broad consensus about the management of nr-axSpA is emerging among clinicians, but the evidence base remains open to question. To explore whether nr-axSpA and AS should be treated similarly, we examined the literature on their prevalence, natural history, disease burden, and treatment...
December 29, 2016: Rheumatology International
https://www.readbyqxmd.com/read/28013432/association-of-human-leukocyte-a-b-and-dr-antigens-in-colombian-patients-with-diagnosis-of-spondyloarthritis
#13
Ana M Santos, Paola Peña, Mabel Avila, Ignacio Briceño, Carlos Jaramillo, Gilberto Vargas-Alarcon, Juan C Rueda, Eugenia-Lucia Saldarriaga, Jose-Ignacio Angarita, Nancy Martinez-Rodriguez, John Londono
There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and Tunisian populations demonstrated the association of SpA and human leukocyte antigen (HLA) B15. The purpose of this study was to evaluate the association of HLA-A, B, and DR antigens in a group of Colombian patients with a diagnosis of SpA. A total of 189 patients and 100 healthy subjects were included in the present study. All subjects underwent a complete characterization of HLA alleles A, B, and DR...
December 24, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28012569/efficacy-of-methylprednisolone-acetate-versus-triamcinolone-acetonide-intra-articular-knee-injection-in-patients-with-chronic-inflammatory-arthritis-a-24-week-randomized-controlled-trial
#14
Ashwani Kumar, Varun Dhir, Shefali Sharma, Aman Sharma, Surjit Singh
PURPOSE: Triamcinolone hexacetonide (TH), triamcinolone acetonide (TA), and methylprednisolone acetate (MPA) are commonly used intra-articular steroid preparations. Studies suggest that intra-articular TH is more efficacious than MPA and TA in chronic inflammatory arthritis. However, it is unclear which of the latter two preparations has better efficacy. Thus, we compared intra-articular knee injections of MPA and TA in patients with chronic inflammatory arthritis. METHODS: This double-blind, randomized controlled trial included patients with rheumatoid arthritis or spondyloarthritis with an acutely swollen knee joint (≥1 week, <24 weeks)...
December 21, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/28008807/the-role-of-hla-class-i-heavy-chain-interactions-with-killer-cell-immunoglobulin-like-receptors-in-immune-regulation
#15
Simon Kollnberger
HLA-class I molecules form trimeric complexes (pMHC) of peptides, class I heavy chains, and β2microglobulins (β2m) that regulate immune responses by binding to T cells and other immune receptors. B2m-free class I heavy chains (FHCs) form on cells either as a consequence of the natural turnover of pMHC or, in the case of HLA-F, are expressed without β2m. Distinct characteristics of certain HLA-class I members, such as HLA-B27 and HLA-F, stabilize these forms facilitating interactions with immune receptors...
2016: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/28002334/gender-differences-among-patients-with-primary-ankylosing-spondylitis-and-spondylitis-associated-with-psoriasis-and-inflammatory-bowel-disease-in-an-iberoamerican-spondyloarthritis-cohort
#16
Margarita Landi, Hernán Maldonado-Ficco, Rodolfo Perez-Alamino, José A Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D Sampaio-Barros, Diana E Flores Alvarado, Rubén Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A Gutiérrez, Elsa Vieyra-Sousa, Fernando Pimentel-Santos, Sergio O Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez
The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by X or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28001233/candida-arthritis-in-a-patient-diagnosed-with-spondyloarthritis
#17
Remzi Çevik, Recep Tekin, Mehmet Gem
Candida arthritis is an unusual manifestation that usually affects the knees. A 35-year-old man presented with a 2-month history of pain and swelling in the right knee. Swelling persisted after anti-inflammatory treatment. Peripheric spondyloarthritis was considered, but methotrexate, sulfasalazine, and methylprednisolone did not reduce the swelling. Direct examination of synovial fluid and a culture were positive for Candida albicans. Intravenous and intra-articular amphotericin-B were administered. The arthritis regressed and a culture and direct staining showed negative results...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27999255/accelerometry-based-activity-recognition-and-assessment-in-rheumatic-and-musculoskeletal-diseases
#18
Lieven Billiet, Thijs Willem Swinnen, Rene Westhovens, Kurt de Vlam, Sabine Van Huffel
One of the important aspects to be considered in rheumatic and musculoskeletal diseases is the patient's activity capacity (or performance), defined as the ability to perform a task. Currently, it is assessed by physicians or health professionals mainly by means of a patient-reported questionnaire, sometimes combined with the therapist's judgment on performance-based tasks. This work introduces an approach to assess the activity capacity at home in a more objective, yet interpretable way. It offers a pilot study on 28 patients suffering from axial spondyloarthritis (axSpA) to demonstrate its efficacy...
December 16, 2016: Sensors
https://www.readbyqxmd.com/read/27998023/clinical-enthesitis-in-a-prospective-longitudinal-psoriatic-arthritis-cohort-incidence-prevalence-characteristics-and-outcome
#19
Ari Polachek, Suzanne Li, Vinod Chandran, Dafna Gladman
OBJECTIVES: The aim of our study was to evaluate the incidence, prevalence, characteristics, disease associations, risk factors and outcome of clinical enthesitis in patients with PsA. METHODS: The study included patients with PsA followed prospectively. Enthesitis was defined as the presence of at least one tender enthesis at one of the 18 entheseal sites of the Spondyloarthritis Research Consortium of Canada enthesitis index. RESULTS: Between 2008 and 2014, 281 of 803 patients had enthesitis providing a prevalence of 35%...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27997346/efficiency-of-treatment-with-non-steroidal-anti-inflammatory-drugs-according-to-current-recommendations-in-patients-with-radiographic-and-non-radiographic-axial-spondyloarthritis
#20
Xenofon Baraliakos, Uta Kiltz, Soeren Peters, Heiner Appel, Friedrich Dybowski, Manfred Igelmann, Ludwig Kalthoff, Dietmar Krause, Hans-Juergen Menne, Ertan Saracbasi-Zender, Elmar Schmitz-Bortz, Mathura Vigneswaran, Juergen Braun
OBJECTIVE: NSAIDs are first-line therapy in axial SpA (axSpA). The proportion of patients responding to NSAIDs and differences between AS and non-radiographic axSpA (nr-axSpA) in this regard have not been studied in detail to date. The aim of this study was to examine the proportion of patients with AS and nr-axSpA responding to NSAIDs according to current treatment recommendations. METHODS: Consecutive anti-TNF-naïve patients with nr-axSpA and AS (n = 50 each) were included if their BASDAI score was ⩾4 without having received maximal NSAID doses...
January 2017: Rheumatology
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