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https://www.readbyqxmd.com/read/29243752/in-situ-carbon-encapsulation-of-vertical-mos2-arrays-with-sno2-for-durable-high-rate-lithium-storage-dominant-pseudocapacitive-behavior
#1
Mengjiao Li, Qinglin Deng, Junyong Wang, Kai Jiang, Zhigao Hu, Junhao Chu
Improving the conductivity and charge transfer kinetics is favourable for innovation of sustainable energy devices such as metal oxide/sulfide-based electrodes. Herein, with an intercalation pseudocapacitance effect, an in situ polymerization-carbonization process for novel carbon-sealed vertical MoS2-SnO2 anchored on graphene aerogel (C@MoS2-SnO2@Gr) has enabled excellent rate performance and durability of the anode of lithium ion batteries to be achieved. The integrated carbon layer and graphene matrix provide a bicontinuous conductive network for efficient electron/ion diffusion pathways...
December 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/29243258/the-diagnostic-pathway-of-oropharyngeal-squamous-cell-carcinoma-in-a-large-u-s-healthcare-system
#2
Jason Gilde, Brian Song, Farzad Masroor, Jeanne A Darbinian, Miranda L Ritterman Weintraub, James Salazar, Eleanor Yang, Deepak Gurushanthaiah, Kevin H Wang
OBJECTIVE: To examine the current diagnostic pathway of oropharyngeal squamous cell carcinoma (OPSCC) and identify factors associated with time to diagnosis. METHODS: Retrospective cohort study of patients with OPSCC in an integrated healthcare system from January 1, 2013, to December 31, 2013. Patient demographics, tobacco and alcohol use, chief complaint, tumor stage, human papilloma virus (HPV) status, physician factors (diagnosis, antibiotic prescription, performance of endoscopic exam, biopsy), and time intervals were examined...
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29241073/resveratrol-inhibits-proliferation-migration-and-invasion-via-akt-and-erk1-2-signaling-pathways-in-renal-cell-carcinoma-cells
#3
Yuwan Zhao, Huancheng Tang, Xin Zeng, Dongcai Ye, Jianjun Liu
Recent studies have shown that resveratrol (RES) inhibits cancer cell growth, migration and invasion. Here, we evaluated RES in two human renal cell carcinoma (RCC) cell lines, ACHN and A498. We investigated the effects of RES on proliferation, cell morphology, colony formation, migration, and invasion. We used a proliferation assay to demonstrate that RES inhibited cell growth with IC50 values 132.9±1.064μM in ACHN, and 112.8±1.191μM in A498, respectively. Using inverted contrast microscopy, we showed that RES reduced cell-to-cell contact and inhibited formation of filopodia...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29239722/calcium-mediated-shaping-of-naive-cd4-t-cell-phenotype-and-function
#4
Vincent Guichard, Nelly Bonilla, Aurélie Durand, Alexandra Audemard-Verger, Thomas Guilbert, Bruno Martin, Bruno Lucas, Cédric Auffray
Continuous contact with self-major histocompatibility complex ligands is essential for the survival of naive CD4 T cells. We have previously shown that the resulting tonic TCR signaling also influences their fate upon activation by increasing their ability to differentiate into induced/peripheral regulatory T cells. To decipher the molecular mechanisms governing this process, we here focus on the TCR signaling cascade and demonstrate that a rise in intracellular calcium levels is sufficient to modulate the phenotype of mouse naive CD4 T cells and to increase their sensitivity to regulatory T-cell polarization signals, both processes relying on Calcineurin activation...
December 14, 2017: ELife
https://www.readbyqxmd.com/read/29237166/kallikrein-cleaves-c3-and-activates-complement
#5
Sarah Irmscher, Nadia Döring, Luke D Halder, Emeraldo A H Jo, Isabell Kopka, Christine Dunker, Ilse D Jacobsen, Shanshan Luo, Hortense Slevogt, Stefan Lorkowski, Niklas Beyersdorf, Peter F Zipfel, Christine Skerka
The human plasma contact system is an immune surveillance system activated by the negatively charged surfaces of bacteria and fungi and includes the kallikrein-kinin, the coagulation, and the fibrinolytic systems. Previous work shows that the contact system also activates complement, and that plasma enzymes like kallikrein, plasmin, thrombin, and FXII are involved in the activation process. Here, we show for the first time that kallikrein cleaves the central complement component C3 directly to yield active components C3b and C3a...
December 14, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29235124/silver-nanoparticles-increase-connexin43-mediated-gap-junctional-intercellular-communication-in-hacat-cells-through-activation-of-reactive-oxygen-species-and-mitogen-activated-protein-kinase-signal-pathway
#6
Yu Qin, Limin Han, Di Yang, Hongying Wei, Yue Liu, Junhui Xu, Herman Autrup, Furong Deng, Xinbiao Guo
Silver nanoparticles (AgNPs) are widely used in health and consumer products that routinely contact skin. However, the biological effects and possible mechanisms of AgNPs on skin remain unclear. Gap junctional intercellular communication (GJIC) plays a critical role in multicellular organisms to maintain tissue homeostasis. The aim of this study is to examine if non-coated AgNPs affect GJIC in human keratinocytes (HaCaT cells), and to identify the possible molecular mechanisms responsible for the effects. GJIC, connexin (Cx)43 protein and mRNA expression, and the effect of siRNA-mediated knockdown of Cx43 on GJIC were assessed...
December 13, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29233911/n-and-o-glycosylation-analysis-of-human-c1-inhibitor-reveals-extensive-mucin-type-o-glycosylation
#7
Kathrin Stavenhagen, H Mehmet Kayili, Stephanie Holst, Carolien Koeleman, Ruchira Engel, Diana Wouters, Sacha Zeerleder, Bekir Salih, Manfred Wuhrer
Human C1-inhibitor (C1-Inh) is a serine protease inhibitor and the major regulator of the contact activation pathway as well as the classical and lectin complement pathways. It is known to be a highly glycosylated plasma glycoprotein. However, both the structural features and biological role of C1-Inh glycosylation are largely unknown. Here, we performed for the first time an in-depth site-specific N- and O-glycosylation analysis of C1-Inh combining various mass spectrometric approaches, including C18-porous graphitized carbon (PGC)-LC-ESI-QTOF-MS/MS applying stepping-energy collision-induced dissociation (CID) and electron-transfer dissociation (ETD)...
December 12, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29232694/hyperbranched-poly-%C3%AF%C2%B5-lysine-substrate-presenting-the-laminin-sequence-yigsr-induces-the-formation-of-spheroids-in-adult-bone-marrow-stem-cells
#8
Valeria Perugini, Steve T Meikle, Anna L Guildford, Matteo Santin
Unlike the fibroblast-like cells formed upon monolayer culture of human mesenchymal stem cells, the natural stem cell niche of the bone marrow and other types of tissues favours the formation of 3-dimensional (3D) cell clusters. The structuring and biological activity of these clusters are regulated by the contacts established by cells with both the basement membrane and neighbour cells and results in their asymmetric division and the consequent maintenance of both a stem population and a committed progeny...
2017: PloS One
https://www.readbyqxmd.com/read/29231737/stability-of-polyethylene-glycol-and-zwitterionic-surface-modifications-in-pdms-microfluidic-flow-chambers
#9
Thomas James Plegue, Kyle M Kovach, Alex J Thompson, Joseph A Potkay
Blood-material interactions are crucial to the lifetime, safety, and overall success of a blood contacting devices. Hydrophilic polymer coatings have been employed to improve device lifetime by shielding blood contacting materials from the natural foreign body response, primarily the intrinsic pathway of the coagulation cascade. These coatings have the ability to repel proteins, cells, bacteria, and other micro-organisms. Coatings are desired to have long-term stability, so that the nonthrombogenic and nonfouling effects gained are long lasting...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29228279/in-vitro-model-of-fully-differentiated-human-nasal-epithelial-cells-infected-with-rhinovirus-reveals-epithelium-initiated-immune-responses
#10
Kai Sen Tan, Hsiao Hui Ong, Yan Yan, Jing Liu, Chunwei Li, Yew Kwang Ong, Kim Thye Thong, Hyung Won Choi, De-Yun Wang, Vincent T Chow
Human rhinoviruses (HRVs) are the commonest cause of the common cold. While less pathogenic compared to other respiratory viruses, it is frequently associated with exacerbation of chronic respiratory diseases such as rhinosinusitis and asthma exacerbation. Currently, there are limited studies on HRV infection of nasal epithelial cells despite being the first site of viral contact, immune initiation, and airway inter-connectivity. Hence, we established a model of HRV infection of in vitro differentiated human nasal epithelial cells (hNECs) derived from multiple individuals...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29226353/biotransformation-and-metabolic-profile-of-xian-ling-gu-bao-capsule-a-traditional-chinese-medicine-prescription-with-rat-intestinal-microflora-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry-analysis
#11
Meng-Xue Gao, Xi-Yang Tang, Feng-Xiang Zhang, Zhi-Hong Yao, Xin-Sheng Yao, Yi Dai
Xian-Ling-Gu-Bao capsule (XLGB), a well-known traditional Chinese medicine prescription (TCMP), has been used for prevention and treatment of osteoporosis. The safety and efficacy of XLGB have been confirmed based on the principle of evidence-based medicine (EBM). XLGB is usually administered orally, after which its multi-components are brought into contacted with intestinal microflora in the alimentary tract and biotransformed. However, investigations on the comprehensive metabolic profile of XLGB are absent...
December 11, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29225891/evaluation-of-a-type-2-diabetes-prevention-program-using-a-commercial-weight-management-provider-for-non-diabetic-hyperglycemic-patients-referred-by-primary-care-in-the-uk
#12
Carolyn Piper, Agnes Marossy, Zoe Griffiths, Amanda Adegboye
Objectives: To determine if a diabetes prevention program (DPP) delivered by a commercial weight management provider using a UK primary care referral pathway could reduce the progression to type 2 diabetes (T2D) in those diagnosed with non-diabetic hyperglycemia (NDH-being at high risk of developing T2D). Research design: This is a quasi-experimental translational research study. Methods: 14 primary care practices identified, recruited and referred patients with NDH (fasting plasma glucose ≥5...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29223801/the-external-face-of-candida-albicans-a-proteomic-view-of-the-cell-surface-and-the-extracellular-environment
#13
Ana Gil-Bona, Ahinara Amador-García, Concha Gil, Lucia Monteoliva
The cell surface and secreted proteins are the initial points of contact between Candida albicans and the host. Improvements in protein extraction approaches and mass spectrometers have allowed researchers to obtain a comprehensive knowledge of these external subproteomes. In this paper, we review the published proteomic studies that have examined C. albicans extracellular proteins, including the cell surface proteins or surfome and the secreted proteins or secretome. The use of different approaches to isolate cell wall and cell surface proteins, such as fractionation approaches or cell shaving, have resulted in different outcomes...
December 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29221947/-the-impact-of-patient-identification-on-an-integrated-program-of-palliative-care-in-basque-country
#14
Igor Larrañaga, Jesús Millas, Myriam Soto-Gordoa, Arantzazu Arrospide, Ricardo San Vicente, Marisa Irizar, Itziar Lanzeta, Javier Mar
OBJECTIVE: Evaluate the process and the economic impact of an integrated palliative care program. DESIGN: Comparative cross-sectional study. LOCATION: Integrated Healthcare Organizations of Alto Deba and Goierri Alto-Urola, Basque Country. PARTICIPANTS: Patients dead due to oncologic and non-oncologic causes in 2012 (control group) and 2015 (intervention group) liable to need palliative care according to McNamara criteria...
December 5, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29215170/synthetic-light-curable-polymeric-materials-provide-a-supportive-niche-for-dental-pulp-stem-cells
#15
Kyle H Vining, Jacob C Scherba, Alaina M Bever, Morgan R Alexander, Adam D Celiz, David J Mooney
Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstructive manner. There is a need for restorative materials that can support native functions of dental pulp stem cells (DPSCs), which are capable of regenerating dentin. A polymer microarray formed from commercially available monomers to rapidly identify materials that support DPSC adhesion is used...
December 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29214807/self-assembled-core-shell-cdte-poly-3-hexylthiophene-nanoensembles-as-novel-donor-acceptor-light-harvesting-systems
#16
Emin Istif, Antonia Kagkoura, Javier Hernández-Ferrer, Anastasios Stergiou, Theodosis Skaltsas, Raul Arenal, Ana M Benito, Wolfgang K Maser, Nikos Tagmatarchis
The self-assembly of novel core-shell nanoensembles consisting of regioregular poly(3-hexylthiophene) nanoparticles (P3HTNPs) of 100 nm as core and semiconducting CdTe quantum dots (CdTeQDs) as shell with a thickness of a few tens of nanometers was accomplished by employing a re-precipitation approach. The structure, morphology and composition of P3HTNPs/CdTeQDs nanoensembles were confirmed by high-resolution scanning transmission microscopy and dynamic light scattering studies. Intimate interface contact between the CdTeQDs shell and the P3HTNPs core leads to the stabilization of the P3HTNPs/CdTeQDs nanoensemble as probed by steady-state absorption spectroscopy...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29212947/requirement-of-treg-intrinsic-ctla4-pkc%C3%AE-signaling-pathway-for-suppressing-tumor-immunity
#17
Christophe Pedros, Ann J Canonigo-Balancio, Kok-Fai Kong, Amnon Altman
The ability of Tregs to control the development of immune responses is essential for maintaining immune system homeostasis. However, Tregs also inhibit the development of efficient antitumor responses. Here, we explored the characteristics and mechanistic basis of the Treg-intrinsic CTLA4/PKCη signaling pathway that we recently found to be required for contact-dependent Treg-mediated suppression. We show that PKCη is required for the Treg-mediated suppression of tumor immunity in vivo. The presence of PKCη-deficient (Prkch-/-) Tregs in the tumor microenvironment was associated with a significantly increased expression of the costimulatory molecule CD86 on intratumoral CD103+ DCs, enhanced priming of antigen-specific CD8+ T cells, and greater levels of effector cytokines produced by these cells...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29212667/lung-tissue-gene-expression-signature-for-the-ageing-lung-in-copd
#18
Maaike de Vries, Alen Faiz, Roy R Woldhuis, Dirkje S Postma, Tristan V de Jong, Don D Sin, Yohan Bossé, David C Nickle, Victor Guryev, Wim Timens, Maarten van den Berge, Corry-Anke Brandsma
INTRODUCTION: COPD is a chronic, progressive, inflammatory disease of the lungs and the third leading cause of death worldwide. The current knowledge of the pathophysiology of COPD is limited and novel insights in underlying disease mechanisms are urgently needed. Since there are clear parallels between ageing and COPD, we investigated genes underlying lung ageing in general and abnormal lung ageing in COPD. METHODS: Whole genome mRNA profiling was performed on lung tissue samples (n=1197) and differential gene expression with increasing age was analysed using an adjusted linear regression model...
December 6, 2017: Thorax
https://www.readbyqxmd.com/read/29209002/the-orientation-and-stability-of-the-gpcr-arrestin-complex-in-a-lipid-bilayer
#19
Dali Wang, Hua Yu, Xiangdong Liu, Jianqiang Liu, Chen Song
G protein-coupled receptors (GPCRs) constitute a large family of membrane proteins that plays a key role in transmembrane signal transduction and draw wide attention since it was discovered. Arrestin is a small family of proteins which can bind to GPCRs, block G protein interactions and redirect signaling to G-protein-independent pathways. The detailed mechanism of how arrestin interacts with GPCR remains elusive. Here, we conducted molecular dynamics simulations with coarse-grained (CG) and all-atom (AA) models to study the complex structure formed by arrestin and rhodopsin, a prototypical GPCR, in a POPC bilayer...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205948/ultrafine-vs4-nanoparticles-anchored-on-graphene-sheets-as-a-high-rate-and-stable-electrode-material-for-sodium-ion-batteries
#20
Qiang Pang, Yingying Zhao, Yanhao Yu, Xiaofei Bian, Xudong Wang, Yingjin Wei, Yu Gao, Gang Chen
Size and conductivity of the electrode materials play a significant role in improving the kinetics of sodium ion batteries. Various characterizations demonstrate that size-controllable VS4 nanoparticles are successfully anchored on graphene sheets (GS) surfaces by a simple cationic surfactant-assisted hydrothermal method. When used as an electrode material for sodium ion batteries, these VS4/GS nanocomposites show large specific capacity (349.1 mA∙h∙g-1 after 100 cycles), excellent long-term stability (84% capacity retention after 1200 cycles), and high rate capability (188...
December 4, 2017: ChemSusChem
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