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https://www.readbyqxmd.com/read/28525815/an-integrated-approach-to-study-the-risk-from-landfill-soil-of-delhi-chemical-analyses-in-vitro-assays-and-human-risk-assessment
#1
Swati, Pooja Ghosh, Indu Shekhar Thakur
In the present study, landfill soil of three municipal solid waste landfill sites of Delhi, India were toxico-chemically analyzed for human risk assessment as inadequate information is available on the possible health effects of the contaminants present in landfill soil. The landfill soil samples were prepared for analyzing heavy metal concentration, organic contaminants and toxicity analysis separately. Composite soil sample collected from three landfill sites were analyzed for heavy metal by ICP-AES. Metal concentration so obtained was below the permissible limit of soil but higher than the set limits for effluent...
May 16, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28522876/comparative-proteomic-analysis-of-the-mitochondria-associated-er-membrane-mam-in-a-long-term-type-2-diabetic-rodent-model
#2
Jacey Hongjie Ma, Shichen Shen, Joshua J Wang, Zhanwen He, Amanda Poon, Jun Li, Jun Qu, Sarah X Zhang
The mitochondria-associated ER membrane (MAM) plays a critical role in cellular energetics and calcium homeostasis; however, how MAM is affected under diabetic condition remains elusive. This study presented a comprehensive proteome profiling of isolated brain MAM from long-term type 2 diabetic mice vs. non-diabetic controls. MAM protein was extracted efficiently by a surfactant-aided precipitation/on-pellet digestion (SOD) method, and MAM proteome was quantified by an ion-current-based MS1 method combined with nanoLC-MS/MS...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28515113/force-sensing-catheters-during-pediatric-radiofrequency-ablation-the-federation-study
#3
Aarti S Dalal, Hoang H Nguyen, Tammy Bowman, George F Van Hare, Jennifer N Avari Silva
BACKGROUND: Based on data from studies of atrial fibrillation ablations, optimal parameters for the TactiCath (TC; St. Jude Medical, Inc) force-sensing ablation catheter are a contact force of 20 g and a force-time integral of 400 g·s for the creation of transmural lesions. We aimed to evaluate TC in pediatric and congenital heart disease patients undergoing ablation. METHODS AND RESULTS: Comprehensive chart and case reviews were performed from June 2015 to March 2016...
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28511899/signaling-pathways-to-and-from-the-hypophysial-pars-tuberalis-an-important-center-for-the-control-of-seasonal-rhythms
#4
REVIEW
Horst Werner-Korf
Seasonal (circannual) rhythms play an important role for the control of body functions (reproduction, metabolism, immune responses) in nearly all living organisms. Also humans are affected by the seasons with regard to immune responses and mental functions, the seasonal affective disorder being one of the most prominent examples. The hypophysial pars tuberalis (PT), an important interface between the hypophysial pars distalis and neuroendocrine centers in the brain, plays an essential role in the regulation of seasonal functions and may even be the seat of the circannual clock...
May 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28510211/insights-into-genome-architecture-deduced-from-the-properties-of-short-lac-repressor-mediated-dna-loops
#5
REVIEW
Pamela J Perez, Wilma K Olson
Genomic DNA is vastly longer than the space allotted to it in a cell. The molecule must fold with a level of organization that satisfies the imposed spatial constraints as well as allow for the processing of genetic information. Key players in this organization include the negative supercoiling of DNA, which facilitates the unwinding of the double-helical molecule, and the associations of DNA with proteins, which partition the DNA into isolated loops, or domains. In order to gain insight into the principles of genome organization and to visualize the folding of spatially constrained DNA, we have developed new computational methods to identify the preferred three-dimensional pathways of protein-mediated DNA loops and to characterize the topological properties of these structures...
November 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28509883/deposition-of-visible-light-active-c-doped-titania-films-via-magnetron-sputtering-using-co%C3%A2-as-a-source-of-carbon
#6
Rachan Klaysri, Marina Ratova, Piyasan Praserthdam, Peter J Kelly
Doping of titanium dioxide with p-block elements is typically described as an efficient pathway for the enhancement of photocatalytic activity. However, the properties of the doped titania films depend greatly on the production method, source of doping, type of substrate, etc. The present work describes the use of pulsed direct current (pDC) magnetron sputtering for the deposition of carbon-doped titania coatings, using CO₂ as the source of carbon; ratios of O₂/CO₂ were varied through variations of CO₂ flow rates and oxygen flow control setpoints...
May 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28507126/direct-observation-of-structure-and-dynamics-during-phase-separation-of-an-elastomeric-protein
#7
Sean E Reichheld, Lisa D Muiznieks, Fred W Keeley, Simon Sharpe
Despite its growing importance in biology and in biomaterials development, liquid-liquid phase separation of proteins remains poorly understood. In particular, the molecular mechanisms underlying simple coacervation of proteins, such as the extracellular matrix protein elastin, have not been reported. Coacervation of the elastin monomer, tropoelastin, in response to heat and salt is a critical step in the assembly of elastic fibers in vivo, preceding chemical cross-linking. Elastin-like polypeptides (ELPs) derived from the tropoelastin sequence have been shown to undergo a similar phase separation, allowing formation of biomaterials that closely mimic the material properties of native elastin...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28506377/beyond-the-pgy-1-community-pharmacy-residency-characterizing-career-pathways-of-residency-graduates
#8
Monet M Stanford, Sarah M Oprinovich, Margie E Snyder
OBJECTIVE: To characterize positions obtained upon graduation from Community Pharmacy Residency Programs (CPRPs). DESIGN: Descriptive nonexperimental study; online cross-sectional survey. SETTING: United States, February to April 2016. PARTICIPANTS: One hundred thirty-three community pharmacy residency program alumni. INTERVENTION: CPRP alumni identified by past program directors were surveyed using 3 contact attempts...
May 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28505514/tlr4-supports-the-expansion-of-fasl-cd5-cd1d-hi-regulatory-b-cells-which-decreases-in-contact-hypersensitivity
#9
Keng Wang, Lei Tao, Jianbing Su, Yueyang Zhang, Binhua Zou, Yiyuan Wang, Min Zou, Nana Chen, Linsheng Lei, Xiaojuan Li
Certain B cells termed as "regulatory B cells" (Bregs) can suppress the ongoing immune responses and a splenic CD5(+)CD1d(hi) Breg subset identified earlier was shown to exert its regulatory functions through secretion of IL-10. Though FasL expression is an alternative mechanism of immune suppression used by B cells, little is known about the FasL expressing CD5(+)CD1d(hi) Bregs. In this study, we isolated splenocytes or splenic CD19(+) B cells and compared the efficiency of toll-like receptor(TLR)4 ligand (lipopolysaccharide) with TLR9 ligand (CpG), anti-CD40 and TLR9 ligand (CpG) plus anti-CD40 on the FasL expression of splenic CD5(+)CD1d(hi) Bregs by flow cytometry...
May 12, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28505149/distinct-dna-binding-surfaces-in-the-atpase-and-linker-domains-of-mutl%C3%AE-determine-its-substrate-specificities-and-exert-separable-functions-in-meiotic-recombination-and-mismatch-repair
#10
Corentin Claeys Bouuaert, Scott Keeney
Mlh1-Mlh3 (MutLγ) is a mismatch repair factor with a central role in formation of meiotic crossovers, presumably through resolution of double Holliday junctions. MutLγ has DNA binding, nuclease, and ATPase activities, but how these relate to one another and to in vivo functions are unclear. Here, we combine biochemical and genetic analyses to characterize Saccharomyces cerevisiae MutLγ. Limited proteolysis and atomic force microscopy showed that purified recombinant MutLγ undergoes ATP-driven conformational changes...
May 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28504692/mint3-mediated-l1cam-expression-in-fibroblasts-promotes-cancer-cell-proliferation-via-integrin-%C3%AE-5%C3%AE-1-and-tumour-growth
#11
H J Nakaoka, Z Tanei, T Hara, J S Weng, A Kanamori, T Hayashi, H Sato, A Orimo, K Otsuji, K Tada, T Morikawa, T Sasaki, M Fukayama, M Seiki, Y Murakami, T Sakamoto
Fibroblasts are some of the major cells in tumour tissues that influence tumour progression and drug resistance. However, our understanding on fibroblast-mediated tumour malignancy remains incomplete. Munc18-1-interacting protein 3 (Mint3) is known as an activator of hypoxia-inducible factor-1 (HIF-1) even during normoxia in cancer cells, macrophages and fibroblasts. Although Mint3 promotes ATP production via glycolysis by activating HIF-1 in cancer cells and macrophages, the biological role of Mint3-mediated HIF-1 activation in fibroblasts remains unclear...
May 15, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28504519/longitudinal-associations-between-adult-children-s-relations-with-parents-and-intimate-partners
#12
Matthew D Johnson, Adam M Galovan, Rebecca M Horne, Joohong Min, Sabine Walper
Drawing on 5 waves of multiple-informant data gathered from focal participants and their parents and intimate partners (n = 360 families) who completed annual surveys in the German Family Panel (pairfam) study, the present investigation examined bidirectional associations between the development of adults' conflictual and intimate interactions with their parents and intimate partners. Autoregressive cross-lagged latent change score modeling results revealed a robust pattern of coordinated development between parent-adult child and couple conflictual and intimate interactions: increases in conflict and intimacy in one relationship were contemporaneously intertwined with changes in the other relationship...
May 15, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28502223/investigation-of-angiogenesis-genes-with-anterior-cruciate-ligament-rupture-risk-in-a-south-african-population
#13
Masouda Rahim, Hayden Hobbs, Willem van der Merwe, Michael Posthumus, Malcolm Collins, Alison V September
The angiogenesis-signalling pathway is a physiological response after mechanical loading to promote matrix remodelling and thereby maintain tissue homeostasis. Studies have shown increased expression of angiogenic molecules in response to loading and in ruptured ligaments. Recently, polymorphisms within the vascular endothelial growth factor A (VEGFA) and kinase insert-domain receptor (KDR) genes were associated with risk of anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy in Caucasian study groups...
May 13, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28501570/electrocatalytic-properties-of-n-doped-graphite-felt-in-electro-fenton-process-and-degradation-mechanism-of-levofloxacin
#14
Xiaocheng Liu, Danxing Yang, Yaoyu Zhou, Jiachao Zhang, Lin Luo, Sijun Meng, Song Chen, Mengjiao Tan, Zhicheng Li, Lin Tang
The degradation of antibiotic levofloxacin was investigated by dimensionally stable anode as well as modified cathode using low-cost chemical reagents of hydrazine hydrate and ethanol for electro-Fenton in an undivided cell at pH 3.0 under room temperature. Comparison of unmodified and modified cathode was performed. The apparent rate constant of levofloxacin decay was found to be 0.2883 min(-1) for graphite felt-10 with the best performance at 200 mA, which is lower than graphite felt at 400 mA. The optimum modified cathode showed a significant improvement of complete mineralization of levofloxacin, reaching a 92% TOC removal at 200 mA for 480 min higher than unmodified one at twice the current...
May 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28498622/regulation-of-raw264-7-macrophage-polarization-on-smooth-and-rough-surface-topographies-by-galectin-3
#15
F Kianoush, M Nematollahi, J D Waterfield, D M Brunette
Recognition of topographical features induces phenotypic changes in macrophages although the receptors and signaling pathways are not completely characterized. As integrin molecules in focal adhesions/podosomes are in intimate contact with topography and topography modulates the NFkB pathway through cholesterol enriched raft-associated adhesive signaling structures we hypothesized that a cell-surface signaling complex comprised of galectin-3 together with its ligand CD98 and integrinβ1 is important for topography-directed lineage determination...
May 12, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28498151/involving-people-who-self-harm-in-research-design
#16
Sandra Walker
BACKGROUND: Involving service users in mental health research is expected in the United Kingdom. PURPOSE: This report outlines the process of exploring a proposed research project with a group of service users. The proposed research project is part of a doctoral pathway that was designed to explore the experiences in a general hospital of people who were admitted with self-harm in terms of their contact with mental health services. METHODS: A consultation event was held where the researcher outlined the proposed format of the project and the expected aims and outcomes...
May 12, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28496425/verbalizations-affect-visuomotor-control-in-hitting-objects-to-distant-targets
#17
Raimey Olthuis, John Van Der Kamp, Simone Caljouw
There is a long-standing proposal for the existence of two neuroanatomically and functionally separate visual systems; one supported by the dorsal pathway to control action and the second supported by the ventral pathway to handle explicit perceptual judgments. The dorsal pathway requires fast access to egocentric information, while the ventral pathway primarily requires allocentric information. Despite the evidence for functionally distinct systems, researchers have posited important interactions. This paper examines evidence to what degree the interaction becomes more important when target-identity, the perception of which is supported by the ventral stream, is verbalized during the execution of a target-directed far-aiming movement...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28495747/reticulon-3-dependent-er-pm-contact-sites-control-egfr-nonclathrin-endocytosis
#18
Giusi Caldieri, Elisa Barbieri, Gilda Nappo, Andrea Raimondi, Massimo Bonora, Alexia Conte, Lisette G G C Verhoef, Stefano Confalonieri, Maria Grazia Malabarba, Fabrizio Bianchi, Alessandro Cuomo, Tiziana Bonaldi, Emanuele Martini, Davide Mazza, Paolo Pinton, Carlo Tacchetti, Simona Polo, Pier Paolo Di Fiore, Sara Sigismund
The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE. We identified NCE-specific regulators, including the endoplasmic reticulum (ER)-resident protein reticulon 3 (RTN3) and a specific cargo, CD147. RTN3 was critical for EGFR/CD147-NCE, promoting the creation of plasma membrane (PM)-ER contact sites that were required for the formation and/or maturation of NCE invaginations...
May 12, 2017: Science
https://www.readbyqxmd.com/read/28492700/coagulation-factor-xi-improves-host-defence-during-murine-pneumonia-derived-sepsis-independent-of-factor-xii-activation
#19
Ingrid Stroo, Sacha Zeerleder, Chao Ding, Brenda M Luken, Joris J T H Roelofs, Onno J de Boer, Joost C M Meijers, Francis J Castellino, Cornelis van 't Veer, Tom van der Poll
Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence during pneumonia and whether this is dependent on FXII activation, we infected in parallel wild-type (WT), FXI knockout (KO) and FXII KO mice with two different clinically relevant pathogens, the Gram-positive bacterium Streptococcus pneumoniae and the Gram-negative bacterium Klebsiella pneumoniae, via the airways...
May 11, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28492236/kondo-blockade-due-to-quantum-interference-in-single-molecule-junctions
#20
Andrew K Mitchell, Kim G L Pedersen, Per Hedegård, Jens Paaske
Molecular electronics offers unique scientific and technological possibilities, resulting from both the nanometre scale of the devices and their reproducible chemical complexity. Two fundamental yet different effects, with no classical analogue, have been demonstrated experimentally in single-molecule junctions: quantum interference due to competing electron transport pathways, and the Kondo effect due to entanglement from strong electronic interactions. Here we unify these phenomena, showing that transport through a spin-degenerate molecule can be either enhanced or blocked by Kondo correlations, depending on molecular structure, contacting geometry and applied gate voltages...
May 11, 2017: Nature Communications
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