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https://www.readbyqxmd.com/read/29236346/therapy-related-acute-myeloid-leukaemia-and-myelodysplastic-syndrome-in-victoria-australia-2003-2014
#1
Doen Ming Ong, Helen Farrugia, Andrew Wei
BACKGROUND: The burden of therapy-related acute myeloid leukaemia (tAML) / therapy-related myelodysplastic syndrome (tMDS) in Australia has not been characterized. METHODS: We analysed adults aged ≥20 years at diagnosis of acute myeloid leukaemia (AML) / myelodysplastic syndrome (MDS) reported to the Victorian Cancer Registry (VCR) between 2003-2014. RESULTS: 73/3,120 (2.3%) AML cases were classified tAML. tAML patients were younger than non-tAML patients at diagnosis (median age 66 vs...
December 13, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29236272/medical-malpractice-and-transoral-robotic-surgery-evaluation-and-some-preemptive-thoughts
#2
Daniel D Lydiatt, Ryan Sewell
Medical malpractice is costly and disruptive, and it is important to prevent. We conducted a study with the objective to look at medical malpractice in robotic surgery overall, to evaluate reasons for litigation, and to comment on possible strategies to avoid litigation with transoral robotic surgery. We used the Westlaw computerized database to identify all state and federal verdict summaries in medical malpractice cases. We found 17 cases alleging malpractice that involved the use of robotic surgery. In all, the plaintiffs in 6 cases (35%) contended that an open rather than a robotic approach should have been used, 5 (29%) alleged negligent credentialing, 4 (24%) alleged training deficiencies, 2 (12%) alleged manufacturing problems, and 1 (6%) charged that robotic surgery should have been performed instead of open surgery (1 case involved two of these allegations)...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236131/trends-in-incidence-and-long-term-outcomes-of-myelomeningocele-in-british-columbia
#3
Taylor North, Alexander Cheong, Paul Steinbok, Julia Ae Radic
PURPOSE: Myelomeningocele is typically a disabling condition that results in neurologic, orthopedic, and urologic morbidity. The aim of this study was to examine the trends over time in both incidence and outcomes of myelomeningocele (MMC) in British Columbia (BC). METHODS: A retrospective chart review was performed of all children with MMC followed in the British Columbia Children's Hospital (BCCH) Spinal Cord Clinic between 1971 and 2016. The incidence of new MMC cases and the long-term outcomes of MMC were compared between two 10-year cohorts...
December 13, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29236105/a-new-potential-energy-surface-of-the-oh2-system-and-state-to-state-quantum-dynamics-studies-of-the-o-h2-reaction
#4
Wentao Li, Jiuchuang Yuan, Meiling Yuan, Yong Zhang, Minghai Yao, Zhigang Sun
A new global potential energy surface (PES) of the O+ + H2 system was constructed with the permutation invariant polynomial neural network method, using about 63 000 ab initio points, which were calculated by employing the multi-reference configuration interaction method with aug-cc-pVTZ and aug-cc-pVQZ basis sets. For improving the accuracy of the PES, the basis set was extrapolated to the complete basis set limit by the two-point extrapolation method. The root mean square error of fitting was only 5.28 × 10-3 eV...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29236075/risks-and-benefits-of-increased-nut-consumption-cardiovascular-health-benefits-outweigh-the-burden-of-carcinogenic-effects-attributed-to-aflatoxin-b%C3%A2-exposure
#5
Hanna Eneroth, Stina Wallin, Karin Leander, Johan Nilsson Sommar, Agneta Åkesson
Nuts are rich in nutrients and mounting evidence shows that consumption reduces cardiovascular disease (CVD) incidence. Nuts may also be a major source of aflatoxin B₁, a potent liver carcinogen and the risk/benefit balance is unknown. Based on national statistics and data from the PREDIMED intervention trial, we estimated the potential CVD-reduction if Swedes aged 55-79 consumed 30 g nuts/day, instead of the current national average of five grams per day. We also assessed the reduction in disability-adjusted life years (DALYs) due to myocardial infarction (MI) and stroke...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29236049/effect-of-monthly-high-dose-long-term-vitamin-d-on-lung-function-a-randomized-controlled-trial
#6
John D Sluyter, Carlos A Camargo, Debbie Waayer, Carlene M M Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years, 58% male) into a randomized, double-blinded, placebo-controlled trial. Participants received, for 1.1 years (median; range = 0.9-1.5 years), either (1) vitamin D₃ 200,000 IU, followed by monthly 100,000 IU doses (n = 226); or (2) placebo monthly (n = 216). At baseline and follow-up, spirometry yielded forced expiratory volume in 1 s (FEV1; primary outcome)...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29235985/deaths-final-data-for-2015
#7
Sherry L Murphy, Jiaquan Xu, Kenneth D Kochanek, Sally C Curtin, Elizabeth Arias
Objectives-This report presents final 2015 data on U.S. deaths, death rates, life expectancy, infant mortality, and trends, by selected characteristics such as age, sex, Hispanic origin and race, state of residence, and cause of death. Methods-Information reported on death certificates, which are completed by funeral directors, attending physicians, medical examiners, and coroners, is presented in descriptive tabulations. The original records are filed in state registration offices. Statistical information is compiled in a national database through the Vital Statistics Cooperative Program of the National Center for Health Statistics...
November 2017: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29235937/the-impact-of-genetically-modified-gm-crops-in-modern-agriculture-a-review
#8
Ruchir Raman
Genetic modification in plants was first recorded 10,000 years ago in Southwest Asia where humans first bred plants through artificial selection and selective breeding. Since then, advancements in agriculture science and technology have brought about the current GM crop revolution. GM crops are promising to mitigate current and future problems in commercial agriculture, with proven case studies in Indian cotton and Australian canola. However, controversial studies such as the Monarch Butterfly study (1999) and the Séralini affair (2012) along with current problems linked to insect resistance and potential health risks have jeopardised its standing with the public and policymakers, even leading to full and partial bans in certain countries...
December 13, 2017: GM Crops & Food
https://www.readbyqxmd.com/read/29235603/a-graphene-mesh-as-a-hybrid-electrode-for-foldable-devices
#9
E H Cho, M J Kim, H Sohn, W H Shin, J Y Won, Y Kim, C Kwak, C S Lee, Y S Woo
A graphene mesh with arrays of micro-holes was fabricated on a polymer substrate using photolithography for use as an electrode in flexible devices. The optimal mesh structure with high optical transmittance and electrical conductivity was designed using a finite element method, in which the conductivity of the mesh was simulated as a function of structure, size, and periodicity of the hole array. The sheet resistance of the graphene mesh was lowered to that of a graphene monolayer by chemical doping and found to be 330 Ω Sq-1 at 98...
December 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29235577/out-of-hospital-cardiac-arrest
#10
Martin Porzer, Eva Mrazkova, Miroslav Homza, Vladimir Janout
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death in developed industrial countries. The global worldwide average of OHCA incidence in adults is 95.9/100,000/year. European incidences vary according to source from 16 to 119/100,000/year. The aim of this study was to provide an overview of current information on OHCA. The incidences in various populations are discussed, along with the factors affecting the prognosis and outcome of these patients. The etiology and pathophysiological mechanisms are also described, especially in relation to the most common causes - acute and chronic forms of coronary artery disease and cardiomyopathies...
December 13, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29235431/using-targeted-solution-tools-as-an-initiative-to-improve-hand-hygiene-challenges-and-lessons-learned
#11
J A Al-Tawfiq, M Treble, R Abdrabalnabi, C Okeahialam, S Khazindar, S Myers
The Joint Commission Centre for Transforming Healthcare's Web-based Targeted Solutions Tool (TST) for improving hand hygiene was implemented to elucidate contributing factors to low compliance rates of hand hygiene. Monitoring of compliance was done by trained unknown and known observers and rates of hospital-acquired infections were tracked and correlated against the changes in hand hygiene compliance. In total, 5669 of hand hygiene observations were recorded by the secret observers. The compliance rate increased from 75·4% at baseline (May-August 2014) to 88·6% during the intervention (13 months) and the control periods (P < 0·0001)...
December 13, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29235294/-simultaneous-determination-of-sixteen-mycotoxins-contaminants-in-cogon-rootstalk-by-quechers-uplc-qqq-mass-spectrometry
#12
Miao-Xuan Fan, Jiao-Jiao Dong, Jing-Hui Wang, Hong-Zhu Guo, You-Gen Chen, Xin-Tong Fu
A method for the simultaneous determination of sixteen mycotoxins in cogon rootstalk was developed using ultra-performance liquid chromatography coupled with triple quadropole mass spectrometry(UPLC-QqQ-MS/MS). The samples were extracted with acetonitrile contained 1% acetic acid and purified by QuEChERS method. The separation was performed on an Agilent Eclipse Plus C₁₈column by gradient elution using methanol and 0.01% aqueous formic acid as mobile phase. The targeted compounds were detected in MRM mode by mass spectrometry with electrospray ionization(ESI)source operated in positive ionization mode...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235280/-advances-on-chemical-constituents-of-tibetan-salvia-genus
#13
REVIEW
Jia Fu, Long-Fei Yang, Jun-Ming Liang, Ling Xu, Gang Zhao, Qiang Fu
Salvia is the largest genus of Labiatae family, and there are more than 1 000 species around the world. Our country is rich in the resources of Salvia plants. The plants of this genus contain multiple chemical components, including sesquiterpenoids, diterpenoids, triterpenoids and phenols, et al. In order to develop better Tibetan plants of Salvia genus, this article reviewed and summarized the constituents from Tibetan Salvia genus.
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235262/corrugated-bruch-s-membrane-in-high-myopia
#14
Jost B Jonas, Rahul A Jonas, Kyoko Ohno-Matsui, Leonard Holbach, Songhomitra Panda-Jonas
PURPOSE: To assess the appearance of Bruch's membrane (BM) in axially elongated eyes. METHODS: The light-microscopical investigation included histological anterior-posterior sections of human eyes. Using a light microscope, we assessed whether BM in the posterior segment was straight or locally corrugated. Corrugation of BM was defined as an elevation of BM with a height >20 μm over a basis of 50 μm without collateral proliferations of retinal pigment epithelium or choroidal swelling...
December 13, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29235250/discovery-and-mechanistic-elucidation-of-a-class-of-pdi-inhibitors-for-the-treatment-of-glioblastoma
#15
Anahita Kyani, Shuzo Tamura, Suhui Yang, Andrea Shergalis, Soma Somanta, Yuting Kuang, Mats Ljungman, Nouri Neamati
Protein disulfide isomerase (PDI) is overexpressed in glioblastoma, the most aggressive form of brain cancer, and folds nascent proteins responsible for the progression and spread of the disease. Herein, we describe a novel, nanomolar PDI inhibitor, pyrimidotriazinedione 35G8, that is toxic in a panel of human glioblastoma cell lines. We performed a medium throughput 20,000-compound screen of a diverse subset of 1,000,000 compounds to identify cytotoxic small molecules. Cytotoxic compounds were screened for PDI inhibition, and, from the screen, 35G8 emerged as the most cytotoxic inhibitor of PDI...
December 12, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29235243/a-waiting-time-of-7%C3%A2-min-is-sufficient-to-reduce-bleeding-in-oculoplastic-surgery-following-the-administration-of-epinephrine-together-with-local-anaesthesia
#16
Jenny Hult, Rafi Sheikh, Cu Dinh Nguyen, Kajsa Tenland, Ulf Dahlstrand, Malin Malmsjö
OBJECTIVE: The time taken to reach maximal haemostatic effect following local anaesthesia with epinephrine is generally believed to be <10 min. This is based on clinical experience and indirect measurements of perfusion using methods such as laser Doppler flowmetry and oxygen spectroscopy. However, the only study in which bleeding has been measured quantitatively in an intra-operative setting in humans showed that the full haemostatic effect was not achieved until 30 min after anaesthesia...
December 13, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29235225/no-change-in-type-2-diabetes-prevalence-in-children-and-adolescents-over-10-years-update-of-a-population-based-survey-in-south-germany
#17
REVIEW
A Neu, L Feldhahn, S Ehehalt, J Ziegler, U Rothe, J Rosenbauer, R W Holl
Objective of this study was to analyze prevalence changes in type 2 diabetes (T2D) among children and adolescents over the last 10 years. We performed a cross-sectional survey in Baden-Württemberg (BW), Germany, by using a written questionnaire and comparing these results with T2D prevalence data from the same area retrieved in 2004/2005. In 2016, 50 patients with T2D under 20 years of age were registered in BW, Germany, which corresponds to a prevalence rate of 2.42 per 100 000 (95% confidence interval [CI]: 1...
December 12, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29235141/pseudomesotheliomatous-carcinoma-of-the-pleura-an-autopsy-case-of-metastasis-from-a-g-csf-producing-anaplastic-carcinoma-of-the-pancreas
#18
Yui Hattori, Kazuhiro Sentani, Takuya Hattori, Naohide Oue, Wataru Yasui
Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81-year-old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36-mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Chest CT showed left pleural thickening with pleural effusion. The cancer showed a poor response to chemotherapy, and the patient died of respiratory failure at 5 months after the onset of disease...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29235012/implications-of-celiac-disease-among-patients-undergoing-gastric-bypass
#19
Lindsey M Freeman, Andrew T Strong, Gautam Sharma, Suriya Punchai, John H Rodriguez, Donald F Kirby, Matthew Kroh
INTRODUCTION: Bariatric surgery is generally safe and effective, but co-existing malabsorptive processes may increase the risk of complications or nutritional deficiencies. Bariatric surgery has not been well studied in the setting of pre-existing celiac disease. MATERIALS AND METHODS: Patients who underwent Roux-en-Y gastric bypass (RYGB) from January 2002 to December 2015 were retrospectively reviewed for either diagnosis of or serum testing for celiac disease...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29234943/enhanced-recovery-care-versus-traditional-care-after-laparoscopic-liver-resections-a-randomized-controlled-trial
#20
Xiao Liang, Hanning Ying, Hongwei Wang, Hongxia Xu, Minjun Liu, Haiyan Zhou, Huiqing Ge, Wenbin Jiang, Lijun Feng, Hui Liu, Yingchun Zhang, Zhiying Mao, Jianhua Li, Bo Shen, Yuelong Liang, Xiujun Cai
BACKGROUND: Enhanced recovery after surgery (ERAS), with several evidence-based elements, has been shown to shorten length of hospital stay and reduce perioperative hospital costs in many operations. This randomized clinical trial was performed to compare complications and hospital stay of laparoscopic liver resection between ERAS and traditional care. METHODS: A randomized controlled trial was performed for laparoscopic liver resection from August 2015 to August 2016...
December 12, 2017: Surgical Endoscopy
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