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https://www.readbyqxmd.com/read/29720929/antioxidant-effects-of-compound-walnut-oil-capsule-in-mice-aging-model-induced-by-d-galactose
#1
Huandong Zhao, Jian Li, Juan Zhao, Yang Chen, Caiping Ren, Yuxiang Chen
Background: Many plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract. Objective: To investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal. Design: 70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29668036/optimization-of-extraction-of-hypoglycemic-ingredients-from-grape-seeds-and-evaluation-of-%C3%AE-glucosidase-and-%C3%AE-amylase-inhibitory-effects-in-vitro
#2
Fansheng Kong, Yaru Qin, Zhipeng Su, Zhengxiang Ning, Shujuan Yu
Grape seeds full with oil and also rich in hypoglycemic ingredients. This study is to improve the comprehensive utilization of grape seeds and the quality of grape seeds oil. Extract water soluble active substances before extracting oil from grape seeds, which show the grape seeds in water soluble extracts containing TP, TC, PC contents, respectively, are 171.1 ± 1.1, 658.8 ± 0.2, 482.3 ± 0.2 (mg GSAE/g). Also we found GSAE samples containing catechin and epicatechin were 44.12 ± 0.21 mg/mL, 111.23 ± 1...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29664082/unsaponifiable-fraction-isolated-from-grape-vitis-vinifera-l-seed-oil-attenuates-oxidative-and-inflammatory-responses-in-human-primary-monocytes
#3
Maria C Millan-Linares, Beatriz Bermudez, Maria E Martin, Ernesto Muñoz, Rocio Abia, Francisco Millan, Francisco J G Muriana, Sergio Montserrat-de la Paz
Grape (Vitis vinifera L.) seed has well-known potential for production of oil as a byproduct of winemaking and is a rich source of bioactive compounds. Herein, we report that the unsaponifiable fraction (UF) isolated from grape seed oil (GSO) possesses anti-oxidative and anti-inflammatory properties towards human primary monocytes. The UF isolated from GSO was phytochemically characterized by GC-MS and HPLC. Freshly obtained human monocytes were used to analyse the effects of GSOUF (10-100 μg mL-1) on oxidative and inflammatory responses using FACS analysis, RT-qPCR, and ELISA procedures...
April 17, 2018: Food & Function
https://www.readbyqxmd.com/read/29603247/optimization-of-ultrasound-assisted-extraction-of-grape-seed-oil-to-enhance-process-yield-and-minimize-free-radical-formation
#4
Bruna R Böger, Aroldo Salviato, Daniel F Valezi, Eduardo Di Mauro, Sandra R Georgetti, Louise E Kurozawa
BACKGROUND: Grape seeds are a relatively abundant source of oil and bioactive compounds. In order to use this by-product, the current work aimed to optimize the ultrasound-assisted extraction of grape seed oil to obtain greater process yield and minimize free radicals formation in the oil. RESULTS: The optimal condition was 15°C and amplitude of ultrasonic wave of 42 μm, leading to a process yield of 82.9% and content of free radicals of 14.7×1017 kg-1 and 3...
March 30, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29452213/nanoemulsion-of-atovaquone-as-a-promising-approach-for-treatment-of-acute-and-chronic-toxoplasmosis
#5
Sanaz Jafarpour Azami, Amir Amani, Hossein Keshavarz, Roqya Najafi-Taher, Mehdi Mohebali, Mohammad Ali Faramarzi, Mahmood Mahmoudi, Saeedeh Shojaee
Treatment of toxoplasmosis is necessary in congenital form and immunocompromised patients. Atovaquone is a powerful suppressor of protozoan parasites with a broad-spectrum activity, but an extremely low water solubility and bioavailability. In this study, nanoemulsion of this drug was prepared with grape seed oil using spontaneous emulsification method to increase bioavailability and efficacy of atovaquone for treatment of toxoplasmosis. In vitro activity of atovaquone nanoemulsion against T. gondii, RH and Tehran strains, was assessed in HeLa cell culture...
May 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29240945/transcript-profiling-indicates-a-widespread-role-for-bacterial-type-phosphoenolpyruvate-carboxylase-in-malate-accumulating-sink-tissues
#6
Michael K Y Ting, Yi-Min She, William C Plaxton
Phosphoenolpyruvate carboxylase (PEPC) is an important regulatory enzyme situated at a key branch point of central plant metabolism. Plant genomes encode several plant-type PEPC (PTPC) isozymes, along with a distantly related bacterial-type PEPC (BTPC). BTPC is expressed at high levels in developing castor oil seeds where it tightly interacts with co-expressed PTPC polypeptides to form unusual hetero-octameric Class-2 PEPC complexes that are desensitized to allosteric inhibition by L-malate. Analysis of RNA-Seq and microarray transcriptome datasets revealed two distinct patterns of tissue-specific BTPC expression in vascular plants...
December 16, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29209877/effects-of-fish-and-grape-seed-oils-as-core-of-haloperidol-loaded-nanocapsules-on-oral-dyskinesia-in-rats
#7
Dalila Moter Benvegnú, Katiane Roversi, Raquel Cristine Silva Barcelos, Fabíola Trevizol, Camila Simonetti Pase, Hecson Jesser Segat, Verônica Tironi Dias, Ana Luiza Savian, Bruna Lopes Piccoli, Jaqueline Piccolo, Carlos Severo Dutra-Filho, Tatiana Emanuelli, Cristiane de Bona da Silva, Ruy Carlos Ruver Beck, Marilise Escobar Burger
Haloperidol is a widely used antipsychotic, despite the severe motor side effects associated with its chronic use. This study was carried out to compare oral dyskinesia induced by different formulations of haloperidol-loaded nanocapsules containing caprylic/capric triglycerides, fish oil or grape seed oil (GSO) as core, as well as free haloperidol. Haloperidol-loaded lipid-core nanocapsules formulations were prepared, physicochemical characterized and administered (0.5 mg kg-1 -ip) to rats for 28 days. Oral dyskinesia was evaluated acutely and subchronically and after that cell viability and free radical generation in cortex and substantia nigra...
February 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29128226/camel-milk-protein-hydrolysates-with-improved-technofunctional-properties-and-enhanced-antioxidant-potential-in-in-vitro-and-in-food-model-systems
#8
Kholoud Awad Al-Shamsi, Priti Mudgil, Hassan Mohamed Hassan, Sajid Maqsood
Camel milk protein hydrolysates (CMPH) were generated using proteolytic enzymes, such as alcalase, bromelain, and papain, to explore the effect on the technofunctional properties and antioxidant potential under in vitro and in real food model systems. Characterization of the CMPH via degree of hydrolysis, sodium dodecyl sulfate-PAGE, and HPLC revealed that different proteins in camel milk underwent degradation at different degrees after enzymatic hydrolysis using 3 different enzymes for 2, 4, and 6 h, with papain displaying the highest degradation...
January 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/28914789/phytochemical-constituents-health-benefits-and-industrial-applications-of-grape-seeds-a-mini-review
#9
REVIEW
Zheng Feei Ma, Hongxia Zhang
Grapes are one of the most widely grown fruits and have been used for winemaking since the ancient Greek and Roman civilizations. Grape seeds are rich in proanthocyanidins which have been shown to possess potent free radical scavenging activity. Grape seeds are a complex matrix containing 40% fiber, 16% oil, 11% proteins, and 7% complex phenols such as tannins. Grape seeds are rich sources of flavonoids and contain monomers, dimers, trimers, oligomers, and polymers. The monomeric compounds includes (+)-catechins, (-)-epicatechin, and (-)-epicatechin-3-O-gallate...
September 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28869529/different-covalent-immobilizations-modulate-lipase-activities-of-hypocrea-pseudokoningii
#10
Marita G Pereira, Susana Velasco-Lozano, Sonia Moreno-Perez, Aline M Polizeli, Paulo R Heinen, Fernanda D A Facchini, Ana C Vici, Mariana Cereia, Benevides C Pessela, Gloria Fernandez-Lorente, Jose M Guisan, João A Jorge, Maria de Lourdes T M Polizeli
Enzyme immobilization can promote several advantages for their industrial application. In this work, a lipase from Hypocrea pseudokoningii was efficiently linked to four chemical supports: agarose activated with cyanogen bromide (CNBr), glyoxyl-agarose (GX), MANAE-agarose activated with glutaraldehyde (GA) and GA-crosslinked with glutaraldehyde. Results showed a more stable lipase with both the GA-crosslinked and GA derivatives, compared to the control (CNBr), at 50 °C, 60 °C and 70 °C. Moreover, all derivatives were stabilized when incubated with organic solvents at 50%, such as ethanol, methanol, n-propanol and cyclohexane...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28822032/synthesis-of-rigid-polyurethane-foams-from-phosphorylated-biopolyols
#11
Juan Carlos de Haro, Daniel López-Pedrajas, Ángel Pérez, Juan Francisco Rodríguez, Manuel Carmona
Renewable resources are playing a key role on the synthesis of biodegradable polyols. Moreover, the incorporation of covalently linked additives is increasing in importance in the polyurethane (PU) market. In this work, previously epoxidized grape seed oil and methyl oleate were transformed into phosphorylated biopolyols through an acid-catalyzed ring-opening hydrolysis in the presence of H3PO4. The formation of phosphate polyesters was confirmed by FT-IR and (31)P-NMR. However, the synthesis of a high-quality PU rigid foam was not possible using exclusively these polyols attending to their low hydroxyl value...
August 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28776625/self-assembled-colloidal-complexes-of-polyphenol-gelatin-and-their-stabilizing-effects-on-emulsions
#12
Yu Huang, Aijun Li, Chaoying Qiu, YingLai Teng, Yong Wang
This research studies the in-depth characteristics including the binding interactions and morphological structure of tannic acid (TA)/grape seed proanthocyanidins (GSP) and gelatin (GLT) colloidal complexes, and evaluated the stability and lipid oxidation of emulsions formed by the colloidal complexes. Polyphenol and GLT (1.2 wt%) self-assembled complexes were fabricated by varying the mass ratio (1 : 16, 1 : 8 and 1 : 4) and pH in the range of 3-7. TA and GSP can form stable colloidal complexes with GLT at the nanoscale at pH 6, as shown by the particle size results, and the complexes exhibited a spherical morphology as seen by transmission electron microscopy...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28740279/effect-of-harvest-time-on-physico-chemical-properties-and-bioactive-compounds-of-pulp-and-seeds-of-grape-varieties
#13
Mehmet Musa Özcan, Fahad Al Juhaimi, Mehmet Gülcü, Nurhan Uslu, Ümit Geçgel, Kashif Ghafoor, Nesim Dursun
In this study, physicochemical properties and bioactive compounds of three grape varieties (Cardinal, Müşküle and Razaki) harvested at the three different harvest times (on time, one and two weeks earlier) were investigated. The highest antioxidant activity, total phenolic and flavonoid contents were observed in Razaki pulp and these were 82.854%, 127.422 mg/100 g, 3.873 mg/g, respectively. The contents of bioactive compounds in grape seeds were found higher than those in pulps. Similarly, seed of Razaki had higher antioxidant activity (91...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28734610/towards-integral-utilization-of-grape-pomace-from-winemaking-process-a-review
#14
REVIEW
Carolina Beres, Gislaine N S Costa, Ignacio Cabezudo, Nina K da Silva-James, Aline S C Teles, Ana P G Cruz, Caroline Mellinger-Silva, Renata V Tonon, Lourdes M C Cabral, Suely P Freitas
Grape is the main fruit crop in several countries. Although many grape-based food products can be found in the market, studies have shown that around 75% of the world grape production is destined for the wine industry. Grape pomace is an abundant by-product from the wine industry, which consists of the remaining skin, seeds and stalks and represents around 25% of total grape weight used in the winemaking process. In countries such as Italy, France and Spain, where wine production is more relevant, the annual grape pomace generation can reach nearly 1200 tonnes per year...
July 19, 2017: Waste Management
https://www.readbyqxmd.com/read/28720935/technological-options-to-control-quality-of-fish-burgers
#15
A Danza, A Conte, M A Del Nobile
This research was focused on preservation strategies applied to develop fish burgers enriched with tomato flour and extra-virgin olive oil. The effects of three different gas mixtures (5:95 O2/CO2; 10:60:30 O2/CO2/N2 and 5:50:45 O2/CO2/N2) on burger quality were analyzed by monitoring microbial cell load of main spoilage microorganisms, pH and sensory properties. As expected, modified atmosphere packaging significantly affected mesophilic bacteria with a reduction of about 2 log cycles for samples under 5% O2 and 95% CO2...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28713708/the-healing-effect-of-grape-seed-oil-enema-with-or-without-sesame-oil-in-acetic-acid-induced-ulcerative-colitis-of-rats
#16
Fatemeh Hosseinzadeh, Moosa Salehi, Nader Tanideh, Davood Mehrabani, Azadeh Sayarifard, Anahita Sedighi
BACKGROUND: Inflammatory bowel diseases contain two digestive system diseases, ulcerative colitis (UC) and Crohn's disease with unclear causes. The aim of present study was to investigate the therapeutic effects of administration of the Sesame oil (SO) and grape seed oil (GSO) as enema route in rats suffering from experimental acetic acid induced UC. METHODS: Eighty male rats were randomly allocated into 8 equal groups as health control (HC1) without any disease treated with 1 ml of normal saline as enema; HC2 received SO; HC3 received GSO; negative control (NC) with induced UC receiving 1 ml of normal saline as enema; and positive control (PC) with induced UC treated by asacol...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28315767/the-properties-of-chitosan-and-gelatin-films-incorporated-with-ethanolic-red-grape-seed-extract-and-ziziphora-clinopodioides-essential-oil-as-biodegradable-materials-for-active-food-packaging
#17
Yasser Shahbazi
The aim of this study was to improve different characteristics including antibacterial, antioxidant, physical and mechanical properties of chitosan (Ch) and gelatin (Ge) films by incorporating Ziziphora clinopodioides essential oil (ZEO; 0 and 1% v/w) and ethanolic grape seed extract (GSE; 0 and 1% v/w). The main compounds of the ZEO were carvacrol (65.22%) and thymol (19.51%). According to our findings, addition of aforementioned materials could improve total phenolic content, antibacterial and antioxidant activities, thickness and also water vapor barrier property...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28300023/optimization-and-validation-of-a-residue-analysis-method-for-glyphosate-glufosinate-and-their-metabolites-in-plant-matrixes-by-liquid-chromatography-with-tandem-mass-spectrometry
#18
Dasharath P Oulkar, Sandip Hingmire, Arnab Goon, Manjusha Jadhav, Bharat Ugare, Ahammed Shabeer Thekkumpurath, Kaushik Banerjee
A sensitive and accurate LC with tandem MS (MS/MS)-based method was developed and validated for the analysis of the herbicide glyphosate, its metabolite aminomethylphosphonic acid (AMPA), and glufosinate after derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) in various plant matrixes. The method also covers direct analysis of the glufosinate metabolites 3-methylphosphinicopropionic acid (3-MPPA) and N-acetyl-glufosinate (NAG). The homogenized samples were extracted with 0.1% formic acid in water-dichloromethane (50 + 50)...
May 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28260647/a-lipidomic-study-on-the-regulation-of-inflammation-and-oxidative-stress-targeted-by-marine-%C3%AF-3-pufa-and-polyphenols-in-high-fat-high-sucrose-diets
#19
Gabriel Dasilva, Manuel Pazos, Eduardo García-Egido, José M Gallardo, Sara Ramos-Romero, Josep Lluís Torres, Marta Romeu, María-Rosa Nogués, Isabel Medina
The ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health is discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats...
May 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28117688/lipidomic-and-antioxidant-response-to-grape-seed-corn-and-coconut-oils-in-healthy-wistar-rats
#20
COMPARATIVE STUDY
Abraham Wall-Medrano, Laura A de la Rosa, Alma A Vázquez-Flores, Gilberto Mercado-Mercado, Rogelio González-Arellanes, José A López-Díaz, Aarón F González-Córdova, Gustavo A González-Aguilar, Belinda Vallejo-Cordoba, Francisco J Molina-Corral
Specialty oils differ in fatty acid, phytosterol and antioxidant content, impacting their benefits for cardiovascular health. The lipid (fatty acid, phytosterol) and antioxidant (total phenolics, radical scavenging capacity) profiles of grapeseed (GSO), corn (CO) and coconut (CNO) oils and their physiological (triacylglycerides, total and HDL-cholesterol and antioxidant capacity (FRAP) in serum and fatty acid and phytosterol hepatic deposition) and genomic (HL, LCAT, ApoA-1 and SR-BP1 mRNA hepatic levels) responses after their sub-chronic intake (10% diet for 28 days) was examined in healthy albino rats...
January 20, 2017: Nutrients
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