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https://www.readbyqxmd.com/read/28644553/structural-insights-into-the-inclusion-complexes-between-clomiphene-citrate-and-%C3%AE-cyclodextrin-the-mechanism-of-preferential-isomeric-selection
#1
Arti Maheshwari, Harish Saraswat, Santosh Kumar Upadhyay
A major challenge in pharmaceuticals for clinical applications is to alter the solubility, stability, and toxicity of drug molecules in living systems. Cyclodextrins (CDs) have the ability to form host-guest inclusion complexes with pharmaceuticals for further development of new drug formulations. The inclusion complex of clomiphene citrate (CL), a poorly water-soluble drug, with native β-cyclodextrin (β-CD) was characterized by a one and two-dimensional nuclear magnetic resonance (NMR) spectroscopic approach and also by molecular docking techniques...
June 23, 2017: Chirality
https://www.readbyqxmd.com/read/28630466/comparative-effectiveness-of-9-ovulation-induction-therapies-in-patients-with-clomiphene-citrate-resistant-polycystic-ovary-syndrome-a-network-meta-analysis
#2
Yiping Yu, Lanlan Fang, Ruizhe Zhang, Jingyan He, Yujing Xiong, Xiaoyi Guo, Qingyun Du, Yan Huang, Yingpu Sun
The comparative efficacies of ovulation-induction treatments in patients with clomiphene citrate-resistant (CCR) polycystic ovary syndrome (PCOS) are not well known. Therefore, we conducted a network meta-analysis to rank the reproductive efficacies of these treatments. We ultimately included 26 randomized clinical trials with 2722 participants and 9 types of therapies: clomiphene citrate (CC), metformin, letrozole, follicle stimulating hormone (FSH), human menopausal gonadotropin (hMG), unilateral laparoscopic ovarian drilling (ULOD), bilateral laparoscopic ovarian drilling (BLOD), the combination of metformin with letrozole (metformin+letrozole), and the combination of metformin with CC (metformin+CC)...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625145/clomiphene-for-the-treatment-of-male-infertility-a-case-report-of-mood-change
#3
Marine Aussedat, Jennifer Jean-Louis, Orchidée Djahangirian, Marie-Sophie Brochet
BACKGROUND: Clomiphene is normally used in women with ovulatory dysfunction. In men, it is used off label in some cases of infertility. Psychological adverse effects are reported in women but very few in men. CASE: A 34 year-old man treated with clomiphene for oligoteratospermia presented anxiety, decreased appetite, and depressed mood making him unable to function properly at work, five days after initiation of therapy. Symptoms required reduction followed by discontinuation of treatment four days later because of absence of improvement...
June 15, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28598116/-optimal-ovulation-induction-in-polycystic-ovary-syndrome-resistant-to-clomiphene-citrate-or-letrozole
#4
Ying Chen, Dan Zhang
OBJECTIVES: To investigate the optimal ovulation induction with the combination of combining letrozole(LE),clomiphene citrate (CC),and human menopausal gonadotropin (HMG) in polycystic ovary syndrome(PCOS) patients resistant to CC or LE. METHODS: Two hundreds nine PCOS patients (209 cycles) resistant to CC or LE were randomly divided into three groups: CC+HMG group (59 cycles),LE+HMG group (72 cycles) and LE+CC group (78 cycles).The patients in LE+CC group unable to form the dominant follicle after 54 cycles were enrolled into LE+CC+HMG group...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28596002/spontaneous-pregnancy-rates-after-reproductive-surgery
#5
Helena Ban Frangez, Sara Korošec, Barbara Pozlep, Nina Jancar, Vesna Salamun, Andrej Vogler, Tanja Burnik Papler, Tea Terezija Cvetko, Eda Vrtacnik Bokal
With the development of IVF procedures, the role of reproductive surgery in the management of infertile couples has been questioned. Pregnancy rates (PR) after IVF procedures are well known, but recent data on spontaneous PR after reproductive surgery are scarce. This study aimed to prospectively evaluate how often fertility is restored by reproductive surgery and to identify which independent factors influence spontaneous pregnancy after reproductive surgery. Eight hundred eighty-eight infertile women who underwent surgery for infertility were prospectively included...
May 22, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28593057/clomiphene-associated-inferior-stemi-in-a-young-female-due-to-right-coronary-artery-dissection
#6
Feras Husain Abuzeyad, Eltigani Seedahmed Ibnaouf, Mudhaffar Al Farras
Nonatherosclerotic spontaneous coronary artery dissection (NA-SCAD) is an uncommon cause of myocardial infarction. It most commonly affects females in the perimenopausal age. NA-SCAD has been associated with many predisposing factors including pregnancy and hormonal therapy for both contraception and ovulation induction. The presented case is a previously healthy 41-year-old woman diagnosed with inferior ST-elevation myocardial infarction due to right descending coronary artery dissection associated with recent use of clomiphene monotherapy for ovulation induction (a previously fertile woman), which was not previously reported...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28557652/comparison-of-clomiphene-citrate-and-letrozole-for-ovulation-induction-in-women-with-polycystic-ovary-syndrome-a-prospective-randomized-trial
#7
Chang Liu, Guimei Feng, Wei Huang, Qiuyi Wang, Shiyuan Yang, Jing Tan, Jing Fu, Dong Liu
To compare the therapeutic efficacy of clomiphene citrate (CC) and letrozole (LE) on ovulation, pregnancy, and live birth in women with polycystic ovary syndrome (PCOS); and to ensure if LE can replace CC as the first-line therapy for ovulation induction in these women. This is a prospectively, randomized, controlled trial in the tertiary hospital. Two-hundred and sixty-eight anovulatory PCOS patients were treated by CC or CC plus metformin and LE or LE plus metformin for three continuous cycles or conception; their ovulation rates, pregnancy rates, and live birth rates were calculated and compared...
May 30, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28551840/pregnancy-after-endometrial-scratching-in-infertile-couples-undergoing-ovulation-induction-and-intrauterine-insemination-cycles-a-randomized-controlled-trial
#8
Tuhina Goel, Reeta Mahey, Neerja Bhatla, Mani Kalaivani, Sangeeta Pant, Alka Kriplani
PURPOSE: To study the effect of endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination (IUI) cycles. METHODS: A prospective randomized controlled trial was conducted in the Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India. One hundred forty-four women with primary/secondary infertility were recruited. Couples were either unexplained or male factor infertility. Subjects were randomized into intervention (scratching) and control group...
May 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28550023/the-super-study-protocol-for-a-randomised-controlled-trial-comparing-follicle-stimulating-hormone-and-clomiphene-citrate-for-ovarian-stimulation-in-intrauterine-insemination
#9
N A Danhof, M van Wely, Cam Koks, J Gianotten, J P de Bruin, B J Cohlen, D P van der Ham, N F Klijn, Mha van Hooff, Fjm Broekmans, K Fleischer, Cah Janssen, J M Rijn van Weert, J van Disseldorp, M Twisk, M Traas, Mfg Verberg, M J Pelinck, J Visser, Dam Perquin, DES Boks, H R Verhoeve, C F van Heteren, Bwj Mol, S Repping, F van der Veen, M H Mochtar
OBJECTIVE: To study the effectiveness of four cycles of intrauterine insemination (IUI) with ovarian stimulation (OS) by follicle-stimulating hormone (FSH) or by clomiphene citrate (CC), and adherence to strict cancellation criteria. SETTING: Randomised controlled trial among 22 secondary and tertiary fertility clinics in the Netherlands. PARTICIPANTS: 732 women from couples diagnosed with unexplained or mild male subfertility and an unfavourable prognosis according to the model of Hunault of natural conception...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28549986/long-term-use-of-clomiphene-citrate-in-induction-of-ovulation-in-pco-patients-with-clomiphene-citrate-resistance
#10
R Elkhateeb, A Ezz El-Din Mahran, H Hassan Kamel
OBJECTIVE: The aim of our study to evaluate the effect of extended clomiphene citrate treatment on the ovulation rate, pregnancy rate, and hormonal profile of clomiphene resistant PCOS. METHODOLOGY: This a prospective study conducted in Maternity Hospital Minia University, 200 patients with PCOS recruited in the study during the period from September 2015 till February 2016 (6 months was duration of the study), they were diagnosed as PCO with clomiphene resistance before being recruited in the study...
May 24, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28547654/potential-teratogenic-effects-of-clomiphene-citrate
#11
REVIEW
Alessandra Scaparrotta, Francesco Chiarelli, Alberto Verrotti
Clomiphene citrate (CC) is the oldest drug used to regulate the process of ovulation. Considering the great use of CC over the last 40 years, it is important to understand the possible risks associated with its use. The aim of this review was to evaluate the possible teratogenic effects of CC, analyzing results obtained from animal and human studies. The pharmacokinetics of CC and possible mechanisms involved in teratogenesis are examined. Fetal exposure to CC is possible due to the long half-life of CC and its metabolites...
May 25, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28496306/erratum-combined-letrozole-and-clomiphene-versus-letrozole-and-clomiphene-alone-in-infertile-patients-with-polycystic-ovary-syndrome-erratum
#12
(no author information available yet)
[This corrects the article on p. 1427 in vol. 7.][This corrects the article on p. 1427 in vol. 7.].
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28494682/operative-transvaginal-hydrolaparoscopy-improve-ovulation-rate-after-clomiphene-failure-in-polycystic-ovary-syndrome
#13
Pierluigi Giampaolino, Nicoletta De Rosa, Luigi Della Corte, Ilaria Morra, Antonio Mercorio, Carmine Nappi, Giuseppe Bifulco
Aim of our study was to assess the ovulation rate, with mid-luteal progesterone level and ultrasound follicles monitoring, in PCOS CC-resistant patients undergone transvaginal hydrolaparoscopy ovarian drilling. A prospective observational study was carried out in 123 PCOS, infertile, CC-resistant patients who undergone THL ovarian drilling. Each woman was evaluated by hormonal measurement, and ultrasound evaluation during 6 months follow-up. Progesterone serum levels were assessed on days 20-24 of the cycle after surgical treatment...
May 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28492445/clomiphene-citrate-associated-with-palinopsia
#14
Seo-Young Choi, Seong-Hae Jeong, Ji-Soo Kim
No abstract text is available yet for this article.
June 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28480767/evaluation-of-tumor-necrosis-factor-alpha-serum-level-in-obese-and-lean-women-with-clomiphene-citrate-resistant-polycystic-ovary-disease
#15
Emaduldin Seyam, Momen Hasan, Eissa M Khalifa, Ahmad Ramadan, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the level of the serum level of tumor necrosis factor alpha (TNF-α) as an inflammatory biomarker in lean and obese women with polycystic ovary disease (PCOD), who are resistant to clomiphene citrate (CCR-PCOD). PATIENTS AND DESIGN: It is a case-controlled study, where 150 (n = 150) PCOD women (study group), who are resistant to clomiphene citrate (CCR-PCOD) had been recruited, in addition to 100 (n = 100) women with PCOD, who are not resistant to clomiphene citrate (NCCR-PCOD) as the first control group, and another 100 women (n = 100) fertile women with normal reproductive health, as the second control group...
May 8, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28473195/-does-fertility-treatment-increase-the-risk-of-breast-cancer-current-knowledge-and-meta-analysis
#16
V Gabriele, J-C Benabu, J Ohl, C Akladios Youssef, C Mathelin
OBJECTIVE: The objective of this review was to assess the level of risk of breast cancer for women exposed to ovulation-inducing therapy (OIT). METHODS: The 25 selected studies were extracted from the PUBMED database from January 2000 until March 2016 with the following key-words: "fertility agents", "infertility treatments", "clomiphene citrate", "buserelin", "ovarian stimulation", "assisted reproductive technology" and "breast cancer". Our meta-analysis was performed using Review Manager software, Cochrane Collaboration, 2014...
May 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28467683/clomiphene-citrate-a-reassuringly-safe-drug
#17
Masoud Afnan
In this edition of the BJOG, Weller and colleagues present a population based study in a single centre over 12 years in which 1,872 of 114,961 women took clomiphene, and showed no increase in the rate of overall or specific major malformations. It provides the best available evidence to date that clomiphene (clomifene) citrate is safe. This article is protected by copyright. All rights reserved.
May 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28462131/effect-of-combination-of-withania-somnifera-dunal-and-tribulus-terrestris-linn-on-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#18
Amrin Saiyed, Nasreen Jahan, Shaikh Ajij Ahmed Makbul, Mushir Ansari, Humaira Bano, Syeda Hajera Habib
BACKGROUND: To investigate the effect of the combination of hydroalcoholic extract of Withania somnifera (WS) and Tribulus terrestris (TT) on letrozole induced polycystic ovarian syndrome (PCOS) in rat. METHODS: Twenty four female Wistar rats of regular estrus cycle were divided into four groups of six animals each. The negative control group received 1 mL of 0.5% carboxy methyl cellulose. The animals of the other groups were treated with letrozole (1 mg/kg) for 21 days for induction of PCOS...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28454491/extension-of-the-clomiphene-citrate-stair-step-protocol-to-gonadotropin-treatment-in-women-with-clomiphene-resistant-polycystic-ovarian-syndrome
#19
Eran Horowitz, David Levran, Ariel Weissman
Our objective was to evaluate the safety and efficacy of direct initiation of gonadotropin ovarian stimulation without prior withdrawal bleeding in anovulatory clomiphene citrate (CC) resistant polycystic ovarian syndrome (PCOS) patients. Eighteen PCOS patients underwent ovulation induction with CC using a stair-step regimen. Patients who failed to respond to the maximal dose of CC initiated gonadotropin stimulation without inducing withdrawal bleeding, using the chronic low dose regimen. The primary outcome measure was the time to ovulation from the beginning of CC treatment until the day of ovulatory trigger...
April 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28412862/impact-of-transvaginal-hydrolaparoscopy-ovarian-drilling-on-ovarian-stromal-blood-flow-and-ovarian-volume-in-clomiphene-citrate-resistant-pcos-patients-a-case-control-study
#20
Pierluigi Giampaolino, Ilaria Morra, Nicoletta De Rosa, Angelo Cagnacci, Massimiliano Pellicano, Costantino Di Carlo, Carmine Nappi, Giuseppe Bifulco
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in gynecology. In PCOS patients vascularization parameters are altered. Transvaginal hydrolaparoscopy (THL) is a mini-invasive approach for ovarian drilling in PCOS patients. In this study, we assessed the effect of ovarian drilling using THL on ovarian volume (OV) and vascularization index (VI) using 3D power Doppler ultrasonography in CC-resistant PCOS patients. A case-control study on 123 CC-resistant PCOS women who underwent THL ovarian drilling was performed...
April 17, 2017: Gynecological Endocrinology
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