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https://www.readbyqxmd.com/read/29150839/liver-injury-induced-by-clomiphene-citrate-a-case-report-and-literature-reviews
#1
H-M Zhang, X-H Zhao, Y-F He, L-R Sun
WHAT IS KNOWN AND OBJECTIVE: Clomiphene citrate is used to cause ovulation in females and to increase semen production in males. Clomiphene citrate is well tolerated in most patients and rarely induces liver injury. We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient. CASE SUMMARY: A 31-year-old man who was treated by clomiphene citrate for 5 days was transferred to our emergency room with reddish-brown urine and upper abdominal pain...
November 17, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29148981/walnut-leaf-extract-acts-as-a-fertility-agent-in-male-wistar-albino-rats-a-search-for-herbal-male-fertility-enhancer
#2
Seun F Akomolafe, Ganiyu Oboh
Background Walnut leaf is one of the many medicinal plants used in folklore as male fertility enhancers. The present work was therefore undertaken with an aim to scientifically validate this claim. As such, we evaluated the effect of the aqueous extract from walnut leaves on biomolecules related to fertility in adult male rats and its mode of action as fertility-enhancing agent. Methods Twenty-five rats were randomly divided into five groups of five animals each; Group 1 served as control and received normal (0...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29142445/a-study-of-controlled-ovarian-stimulation-with-clomiphene-citrate-or-letrozole-in-combination-with-gonadotropins-and-iui-in-unexplained-infertility
#3
Madhusmita Hembram, Ratna Biswas, Anju Jain
Aim: To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Settings and Design: Non-randomised interventional study. Patients and Methods: A total number of 60 patients in the age group of 20-35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29134975/plasma-interleukin-1%C3%AE-il-1%C3%AE-concentrations-at-the-different-phases-of-the-oestrus-cycle-in-clomiphene-treated-female-rats
#4
S Co Nwangwu, S J Josiah, C U Urom-Ndubuisi, S I Owoeye, P E Osagiede, A W Oyeyemi, D R Omotosho
Interleukin - 1β (IL-1β) is a signal molecule known for its role in inflammation and immune response. However,there are reports on the possible effects of IL-1β in ovulation and various aspects on female reproduction. It was thereforenecessary to determine plasma IL-1β levels in female rats administered ovulation inducing agent clomiphene citrate. In thiswork, a total of forty (40) female wistar rats weighing between 150g and 225g were used. Twenty of the rats wereadministered 0.14mg/kg clomiphene citrate orally daily for five days while the other twenty which served as control, receivednormal saline...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29125183/ovarian-surgery-for-symptom-relief-in-women-with-polycystic-ovary-syndrome
#5
REVIEW
Sam Lepine, Junyoung Jo, Mostafa Metwally, Ying C Cheong
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine condition, affecting approximately one in 10 women. PCOS is defined by two of three features: oligo- or anovulation, clinical or biochemical hyperandrogenism or both, or polycystic ovaries.Women with PCOS can have a wide range of health problems, including infrequent and irregular periods, unwanted hair growth and acne, and subnormal fertility. Long-term health concerns include an increased risk of heart disease, diabetes and the development of precancerous disease of the womb...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29106989/gonadal-hormones-affect-alcohol-drinking-but-not-cue-yohimbine-induced-alcohol-seeking-in-male-and-female-rats
#6
Megan L Bertholomey, Mary M Torregrossa
Alcohol use disorder (AUD) is a chronic, relapsing disease characterized by maladaptive patterns of alcohol drinking and seeking. Though sex differences exist in the etiology of AUD, much remains to be elucidated concerning the mechanisms underlying sex-related vulnerability to developing excessive alcohol-motivated behavior. While a large body of evidence points to an important role of circulating gonadal hormones in mediating cocaine reinforcement, findings are less consistent with respect to ethanol. Critically, the effects of gonadal hormones on the reinstatement of ethanol seeking, a model of "craving"-like behavior that reveals pronounced sex differences, has not yet been examined...
October 26, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29100822/-which-ovarian-stimulation-to-which-women-the-polycystic-ovary-syndrome-pcos
#7
P Merviel, S Bouée, M Ménard, M-T Le Martelot, S Roche, C Lelièvre, J-J Chabaud, C Jacq, H Drapier, D Beauvillard
Polycystic ovarian syndrome (PCOS) is a frequent pathology in the young woman, linking infertility to a metabolic disease. Initial support will include a plan (in the case of overweight or obesity) to lose at least 5 to 10% of the weight. Subsequently, clomiphene citrate is the first treatment for ovulation induction with pregnancy rates of 40 to 80% after 6 cycles. If there is resistance to clomiphene citrate, the choice will be between the ovarian drilling (50-60% of pregnancy in the year following, including the half spontaneous) or ovarian stimulation with gonadotropins...
October 31, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29096046/oral-medications-including-clomiphene-citrate-or-aromatase-inhibitors-with-gonadotropins-for-controlled-ovarian-stimulation-in-women-undergoing-in-vitro-fertilisation
#8
REVIEW
Mohan S Kamath, Abha Maheshwari, Siladitya Bhattacharya, Kar Yee Lor, Ahmed Gibreel
BACKGROUND: Gonadotropins are the most commonly used medications for controlled ovarian stimulation in in vitro fertilisation (IVF). However, they are expensive and invasive, and are associated with the risk of ovarian hyperstimulation syndrome (OHSS). Recent calls for more patient-friendly regimens have led to growing interest in the use of clomiphene citrate (CC) and aromatase inhibitors with or without gonadotropins to reduce the burden of hormonal injections. It is currently unknown whether regimens using CC or aromatase inhibitors such as letrozole (Ltz) are as effective as gonadotropins alone...
November 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29081619/treatment-outcome-of-ovulation-inducing-agents-in-patients-with-anovulatory-infertility-a-prospective-observational-study
#9
Kinjal Prajapati, Mira Desai, Samidh Shah, Sumesh Choudhary, Rohina Aggarwal, Vineet Mishra
OBJECTIVE: To compare different treatment regimens on pregnancy rate and outcome in patients with anovulatory infertility. PATIENTS AND METHODS: A prospective observational study was conducted on patients with infertility due to anovulation. Patients treated with clomiphene citrate (CC) 50/100 mg/day from 2(nd) to 6(th) day of menstrual cycle (MC) (n = 38), short gonadotropin-releasing hormone (GnRH) agonist regimen (leuprolide [0.5 mg subcutaneous] + recombinant follicle-stimulating hormone [rFSH] [225 IU intramuscular [IM] from 2(nd) to 10(th) day of MC [n = 32]), long GnRH agonist regimen (leuprolide from 21(st) day followed by leuprolide + rFSH from 2(nd) to 10(th) day of MC [n = 19]), and antagonist regimen (human menopausal gonadotropin [hMG] [150 IU IM] from 2(nd) day followed by hMG + cetrorelix from 7(th) to 10(th) day of MC) (n = 6) were recruited and followed up for follicular size, endometrial thickness, and pregnancy test...
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29076376/clomiphene-citrate-combined-with-metformin-versus-letrozole-for-induction-of-ovulation-in-clomiphene-resistant-polycystic-ovary-syndrome-a-randomized-clinical-trial
#10
Mohamed Rezk, Abd-Elhamid Shaheen, Ibrahim Saif El-Nasr
A total of 202 patients with clomiphene citrate (CC) -resistant polycystic ovary syndrome (PCOS) were randomly allocated into two arms of induction of ovulation; the first group (n = 102) received CC 100 mg and metformin 500 mg while the second group (n = 100) received letrozole 2.5 mg with ovulation rate, clinical pregnancy rate, adverse effects, and acceptability were assessed. Patients in the letrozole arm experienced higher rate of ovulation (82% versus 43.1%, p < .001), more dominant follicles (p < ...
October 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29062796/controlled-ovarian-hyperstimulation-with-intrauterine-insemination-is-more-successful-after-r-hcg-administration-than-spontaneous-lh-surge
#11
Evan Taerk, Edward Hughes, Cassandra Greenberg, Michael Neal, Shilpa Amin, Mehrnoosh Faghih, Megan Karnis
BACKGROUND: The purpose of this study was to evaluate whether clinical pregnancy rate is affected by timing intrauterine insemination (IUI) according to serum LH surge, r-hCG trigger, or a combination of LH surge and r-hCG trigger in controlled ovarian hyperstimulation (COH) cycles for patients with a variety of infertility etiologies. METHODS: The last 365 consecutive COH-IUI cycles performed at ONE Fertility Burlington in 2014 were reviewed and categorized according to method of IUI timing...
July 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29055102/the-effect-of-clomiphene-citrate-on-endometrial-thickness-ovulation-pregnancy-and-live-birth-in-anovulatory-women-a-systematic-review-and-meta-analysis
#12
REVIEW
Moustafa A Gadalla, Shuo Huang, Rui Wang, Robert J Norman, Sayed A Abdullah, Ali M El Saman, Alaa M Ismail, Madelon van Wely, Ben W J Mol
OBJECTIVES: To compare the impact of clomiphene citrate (CC) versus other drug regimens on mid-cycle endometrial thickness (EMT), ovulation, pregnancy and live birth rates in women with WHO group II ovulatory disorders. METHODS: We searched MEDLINE, EMBASE, Scopus, Web of Science, The Cochrane Central Register of Clinical Trial (CENTRAL), and the non-MEDLINE subset of PubMed from inception to December 2016 and cross-checked references of relevant articles. We only included randomized controlled trials (RCTs) comparing CC used alone versus other drug regimens for ovulation induction in women with WHO group II anovulation...
October 21, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29043882/ovarian-volume-and-pcos-a-controversial-issue
#13
Pierluigi Giampaolino, Luigi Della Corte, Nicoletta De Rosa, Antonio Mercorio, Dario Bruzzese, Giuseppe Bifulco
Polycystic ovarian syndrome (PCOS) is a common endocrinopathy. The Rotterdam criteria indicate four distinct phenotypes. In phenotypes with the typical ovarian morphology (ovarian volume ≥10 ml) the sensibility to clomiphene citrate (CC) ovulation therapy was demonstrated inversely proportional to the ovarian volume. In this retrospective study we evaluated the influence of ovarian volume on the success rate of CC ovulation induction in women with anovulatory phenotype 2 characterized only by the presence of hyperandrogenism and anovulation (ANOV + HA)...
October 18, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29017436/role-of-markov-modeling-approaches-to-understand-the-impact-of-infertility-treatments
#14
Arni S R Srinivasa Rao, Michael P Diamond
We are proposing to use Markov modeling type of analysis to understand data generated by treatments for infertility in women receiving ovarian stimulations. We describe the conceptual novelties, need for such an analysis, basics of the proposed methods, and theoretical constructions of various probabilities associated with practical level implementation of the Markov modeling procedures. This method can be adopted to infertility-related data visualizations whenever progression of outcome stages in infertility treatment is recorded...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28977141/clomiphene-treatment-may-be-effective-in-refractory-episodic-and-chronic-cluster-headache
#15
Maria Eduarda Nobre, Mario Fernando Prieto Peres, Pedro Ferreira Moreira, Antonio José Leal
OBJECTIVE: To describe the evolution of 15 patients who were treated for difficult-to-control episodic and chronic cluster headaches with clomiphene. METHODS: Clomiphene treatment was used for seven chronic and eight episodic cluster headache patients. The chronic patients were refractory to the medication being used, and the episodic patients, in addition to being resistant to conventional medication, had longer cluster headache periods, exceeding the average time of previous cluster cycles...
September 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28969562/ovarian-stimulation-in-poor-responders-have-we-made-progress
#16
Robert Roman, Naiha Mussarat, Laura Detti
BACKGROUND: Poor ovarian responders (POR) pose a challenge to a physicians' ability to choose a stimulation protocol that maximizes the number of oocytes harvested and their chances of conception with multiple protocols aimed at improving pregnancy rates in this poor prognosis population. The Bologna criteria standardized the diagnosis of POR and allows for a more homogenous patient population in clinical trials. METHODS: A structured review of the literature, which encompasses research on Bologna-defined POR, identified several proposed protocols to optimize pregnancy rates in poor responders...
October 2, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28965550/in%C3%A2-vitro-fertilization-treatments-with-the-use-of-clomiphene-citrate-or-letrozole
#17
REVIEW
Jigal Haas, Robert F Casper
There has been increasing interest in combining the oral agents clomiphene citrate (CC) and letrozole with gonadotropins in IVF: for poor responders to reduce the amount of gonadotropins used, and in normal responders to reduce the incidence of ovarian hyperstimulation (OHSS). In normal responders, mild stimulation with the use of CC and gonadotropins was found to decrease the number of oocytes retrieved and result in good pregnancy rates, but in most studies the cumulative pregnancy rate was lower compared with conventional ovarian stimulation when frozen embryo transfers were considered...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28951677/the-effect-of-metformin-use-on-pregnancy-rates-among-polycystic-ovary-syndrome-patients-undergoing-in-vitro-fertilization-a-retrospective-cohort-study
#18
Yazed Sulaiman Al-Ruthia, Hazem Al-Mandeel, Hisham AlSanawi, Bander Balkhi, Wael Mansy, Reem AlGasem, Lama AlMutairi
BACKGROUND: Metformin is widely used with gonadotropins by women with polycystic ovary syndrome (PCOS) during in vitro fertilization (IVF) to increase their chances of pregnancy. The aim of this study was to evaluate the efficacy of metformin in improving the rates of clinical pregnancy among women with PCOS undergoing IVF. METHODS: This was a retrospective cohort study of women with PCOS, aged 18-40 years, undergoing IVF during 2006-2012 at a University Hospital in Riyadh, Saudi Arabia...
September 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28938064/re-clomiphene-citrate-and-letrozole-to-reduce-follicle-stimulating-hormone-consumption-during-ovarian-stimulation-systematic-review-and-meta-analysis-t-n-bechtejew-m-n-nadai-c-o-nastri-and-w-p-martins-ultrasound-obstet-gynecol-2017-50-315-323
#19
COMMENT
https://www.readbyqxmd.com/read/28921794/cerebral-palsy-clinical-safety-of-clomiphene-citrate-bjog-s-impact
#20
EDITORIAL
Patrick Chien
No abstract text is available yet for this article.
October 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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