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https://www.readbyqxmd.com/read/29334275/laparoscopic-ovarian-drilling-versus-gnrh-antagonist-combined-with-cabergoline-as-a-prophylaxis-against-the-re-development-of-ovarian-hyperstimulation-syndrome
#1
Emaduldin Seyam, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the value of laparoscopic ovarian drilling (LOD) compared with GnRH antagonist flexible protocol combined with cabergoline (Cb), as a prophylaxis against the re-development of ovarian hyperstimulation syndrome (OHSS) in women with clomiphene citrate-resistant polycystic ovary disease (CCR-PCOD) who had severe OHSS before in a previous ICSI cycle. STUDY DESIGN: It is a prospective controlled study, where 250 CCR-PCOD women (n = 250) with a history of severe OHSS before, had been recruited for the study...
January 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29317127/low-dosing-of-gonadotropins-in-in%C3%A2-vitro-fertilization-cycles-for-women-with-poor-ovarian-reserve-systematic-review-and-meta-analysis
#2
Mohamed Abdel-Fattah Youssef, Madelon van Wely, Monique Mochtar, Usama Mohamed Fouda, Ashraf Eldaly, Eman Zein El Abidin, Ahmed Elhalwagy, Ahmed Abdel Mageed Abdallah, Sherif Sameh Zaki, Mohamed Sayed Abdel Ghafar, Mohamed Nagi Mohesen, Fulco van der Veen
OBJECTIVE: To evaluate the effectiveness of low doses of gonadotropins and gonadotropins combined with oral compounds compared with high doses of gonadotropins in ovarian stimulation regimens in terms of ongoing pregnancy per fresh IVF attempt in women with poor ovarian reserve undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment. DESIGN: A systematic review and meta-analysis of randomized controlled studies that evaluate the effectiveness of low dosing of gonadotropins alone or combined with oral compounds compared with high doses of gonadotropins in women with poor ovarian reserve undergoing IVF/ICSI treatment...
January 6, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29259477/weight-reduction-using-a-formula-diet-recovers-menstruation-in-obese-patients-with-an-ovulatory-disorder
#3
Toshiya Matsuzaki, Tsutomu Douchi, Toshimichi Oki, Osamu Ishihara, Ryugo Okagaki, Takeshi Kajihara, Midori Tamura, Fumikazu Kotsuji, Kimihisa Tajima, Mika Kawano, Bunpei Ishizuka, Minoru Irahara
Aim: To determine the effectiveness of a formula diet in weight reduction and the recovery of menstruation in obese patients with ovulatory disorders. Methods: After the enrollment of 39 obese women with ovulatory disorders, they replaced one or two of their three normal meals with a microdiet (MD) (240 kcal/meal) for 24 weeks. Physical, endocrinological, and biochemical tests were conducted before and at 12 and 24 weeks of the study. Of the 39 women enrolled, 26 were not taking clomiphene...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259467/clinical-outcome-of-various-metformin-treatments-for-women-with-polycystic-ovary-syndrome
#4
Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Takeshi Iwasa, Munkhsaikhan Munkhzaya, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
Aim: Polycystic ovary syndrome (PCOS) is an ovulatory disorder and insulin resistance and diabetes are involved in its pathophysiology. Metformin, an anti-diabetic agent, has been reported to be useful to induce ovulation. Methods: Metformin treatment was classified into four types: (1) clomiphene-metformin combination treatment for clomiphene-resistant patients; (2) clomiphene-metformin combination for clomiphene-sensitive patients; (3) clomiphene-metformin combination for naïve patients; and (4) metformin monotherapy...
April 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29258385/a-comparison-of-treatment-results-of-the-different-treatment-protocols-in-patients-with-poor-ovarian-response
#5
Ilhan Sanverdi, Huseyin Tayfun Kutlu, Bulent Emre Bilgic, Adnan Incebiyik
To compare the effect of the different protocols in patients receiving in vitro fertilization treatment due to poor ovarian response. Seventy-seven of the patients included in the study were treated with gonadotropin (450 IU) + GnRH antagonist (group 1), 84 of the patients were treated with gonadotropin (450 IU) + microdose GnRH analog (group 2), and 53 of the patients were treated with clomiphene citrate (100 mg/day) + gonadotropin (300 IU) + GnRH antagonist (Group 3). In assessing total gonadotropin dosage, patients in Group 3 detected significantly less gonadotropin as compared to the other two groups (p < ...
December 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29247457/progestin-primed-ovarian-stimulation-with-or-without-clomiphene-citrate-supplementation-in-normal-ovulatory-women-undergoing-in-vitro-fertilization-intracytoplasmic-sperm-injection-a-prospective-randomized-controlled-trial
#6
Yali Liu, Qiuju Chen, Sha Yu, Yun Wang, Wen He, Hannah Ya-Ning Chang, Bian Wang, Hongyuan Gao, Hui Long, Li Wang, Qifeng Lyu, Ai Ai, Yanping Kuang
OBJECTIVE: To compare the endocrinological profiles, cycle characteristics and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) with or without clomiphene citrate (CC) supplementation in normal ovulatory women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective randomized controlled study. PATIENT(S): A total of 320 infertile women undergoing IVF/ICSI. Medroxyprogesterone acetate (MPA) and human menopausal gonadotropin (hMG) were simultaneously administered on menstrual cycle day 3...
December 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29243443/-effect-of-clomiphene-citrate-and-dingkun-dan-on-ovulation-induction-and-clinical-pregnancy-of-polycystic-ovary-syndrome
#7
Lan Chen, Yong Tan, Shu-Ping Chen
The evaluation is based on clomiphene citrate (CC)+gonadotropin (Gn), clinical study on CC and Dingkun Dan's treatment on ovulation induction and clinical pregnancy effect of PCOS, and to provide ideas and methods for traditional Chinese medicine assisted reproductive treatment. This study selected 60 PCOS infertility patients treated with ovulation induction in reproductive medicine clinic, Jiangsu Province Hospital of traditional Chinese medicine during 2015-10-01-2017-04-23. They were randomly divided into two groups: Group A (CC+Gn+HCG) and Group B (CC+Gn+Dingkun Dan)...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29241929/fertility-outcomes-following-pelvic-embolization-in-women-with-acquired-uterine-arteriovenous-malformation
#8
Cheng-Yu Ho, Kok-Min Seow, Lee-Wen Huang, Yieh-Loong Tsai
OBJECTIVE: Acquired uterine arteriovenous malformation (UAVM) is a rare, life-threatening disease. Angiography with uterine arterial embolization (UAE) is the diagnostic tool and a choice of fertility-sparing treatment. Here, we present a series of five successful pregnancies after embolization of UAVM. CASE REPORTS: Three reproductive aged women were treated for UAVM, resulting in five successful pregnancies. Their past history suggested that three cases had had previous uterine procedures, including second trimester abortion and elective dilatation and curettage...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29235035/is-acupuncture-actually-not-effective-for-polycystic-ovary-syndrome-analysis-of-the-trial-published-in-jama
#9
Wei-Juan Gang, Xiang-Hong Jing
In recent years, acupuncture has been applied to treat more and more patients suffering from polycystic ovary syndrome (PCOS). On June 27, 2017 a paper titled "Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial" was published in Journal of the American Medical Association (JAMA). The results did not support acupuncture as an effective therapy for improving the live births in PCOS. The aim of this article was to analyze the therapeutic regimen and design of the clinical trial...
December 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29231340/-herb-partitioned-moxibustion-on-navel-for-anovulatory-infertility-a-randomized-controlled-trial
#10
Zhaofeng Li, Hui Wang, Mingyao Hao, Xuan Wang, Yanpu Yu, Yuxia Ma
OBJECTIVE: To observe the efficacy differences between herb-partitioned moxibustion on navel and clomiphene for anovulatory infertility. METHODS: With double-blind double-dummy randomized control method, a total of 40 patients with anovulatory infertility were randomly divided into a moxibustion group and a clomiphene group, 20 cases in each one. Blinding was conducted on both patients and doctors. The patients in the moxibustion group were treated with herb-partitioned moxibustion on navel and oral administration of clomiphene placebo, while the patients in the clomiphene group were treated with placebo-partitioned moxibustion on navel and oral administration of clomiphene...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29215516/clomiphene-stair-step-protocol-for-women-with-polycystic-ovary-syndrome
#11
Tiffanny Jones, Jacqueline R Ho, Marc Gualtieri, Janet Bruno-Gaston, Karine Chung, Richard J Paulson, Kristin A Bendikson
OBJECTIVE: To compare time to ovulation, ovulation rates, and side effect profile of traditional and the stair-step protocol for ovulation induction using clomiphene citrate in women with polycystic ovary syndrome (PCOS). METHODS: We performed a retrospective study of women seeking care for infertility with a diagnosis of PCOS at a university-based infertility clinic from July 2012 to July 2014. We included patients who were resistant to the initial starting dose of 50 mg clomiphene...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29183107/insulin-sensitising-drugs-metformin-rosiglitazone-pioglitazone-d-chiro-inositol-for-women-with-polycystic-ovary-syndrome-oligo-amenorrhoea-and-subfertility
#12
REVIEW
Lara C Morley, Thomas Tang, Ephia Yasmin, Robert J Norman, Adam H Balen
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with increased risk of cardiovascular disease and diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation. OBJECTIVES: To evaluate the effectiveness and safety of insulin-sensitising drugs in improving reproductive and metabolic outcomes for women with PCOS undergoing ovulation induction...
November 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29159661/safety-of-clomiphene-citrate-a-literature-review
#13
REVIEW
Serkan Yilmaz, Neslihan Yilmaz Sezer, İlknur Münevver Gönenç, Sibel Erkal İlhan, Ebru Yilmaz
Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not? In the light of this question, this review aimed to highlight all researches and insights into the association between the use of CC and risk of genotoxicity, cytotoxicity, embryotoxicity, teratogenicity and risk of different cancer types. We conducted a MEDLINE/PubMed, Scopus, Web of Science, Google Scholar search. After a careful screening process of all authors, 32 of these articles were considered as appropriate, and reviewed...
November 20, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29150839/liver-injury-induced-by-clomiphene-citrate-a-case-report-and-literature-reviews
#14
H-M Zhang, X-H Zhao, Y-F He, L-R Sun
WHAT IS KNOWN AND OBJECTIVE: Clomiphene citrate is used to cause ovulation in females and to increase semen production in males. Clomiphene citrate is well tolerated in most patients and rarely induces liver injury. We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient. CASE SUMMARY: A 31-year-old man who was treated by clomiphene citrate for 5 days was transferred to our emergency room with reddish-brown urine and upper abdominal pain...
November 17, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29148981/walnut-leaf-extract-acts-as-a-fertility-agent-in-male-wistar-albino-rats-a-search-for-herbal-male-fertility-enhancer
#15
Seun F Akomolafe, Ganiyu Oboh
Background Walnut leaf is one of the many medicinal plants used in folklore as male fertility enhancers. The present work was therefore undertaken with an aim to scientifically validate this claim. As such, we evaluated the effect of the aqueous extract from walnut leaves on biomolecules related to fertility in adult male rats and its mode of action as fertility-enhancing agent. Methods Twenty-five rats were randomly divided into five groups of five animals each; Group 1 served as control and received normal (0...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29142445/a-study-of-controlled-ovarian-stimulation-with-clomiphene-citrate-or-letrozole-in-combination-with-gonadotropins-and-iui-in-unexplained-infertility
#16
Madhusmita Hembram, Ratna Biswas, Anju Jain
Aim: To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Settings and Design: Non-randomised interventional study. Patients and Methods: A total number of 60 patients in the age group of 20-35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29134975/plasma-interleukin-1%C3%AE-il-1%C3%AE-concentrations-at-the-different-phases-of-the-oestrus-cycle-in-clomiphene-treated-female-rats
#17
S Co Nwangwu, S J Josiah, C U Urom-Ndubuisi, S I Owoeye, P E Osagiede, A W Oyeyemi, D R Omotosho
Interleukin - 1β (IL-1β) is a signal molecule known for its role in inflammation and immune response. However,there are reports on the possible effects of IL-1β in ovulation and various aspects on female reproduction. It was thereforenecessary to determine plasma IL-1β levels in female rats administered ovulation inducing agent clomiphene citrate. In thiswork, a total of forty (40) female wistar rats weighing between 150g and 225g were used. Twenty of the rats wereadministered 0.14mg/kg clomiphene citrate orally daily for five days while the other twenty which served as control, receivednormal saline...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29125183/ovarian-surgery-for-symptom-relief-in-women-with-polycystic-ovary-syndrome
#18
REVIEW
Sam Lepine, Junyoung Jo, Mostafa Metwally, Ying C Cheong
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine condition, affecting approximately one in 10 women. PCOS is defined by two of three features: oligo- or anovulation, clinical or biochemical hyperandrogenism or both, or polycystic ovaries.Women with PCOS can have a wide range of health problems, including infrequent and irregular periods, unwanted hair growth and acne, and subnormal fertility. Long-term health concerns include an increased risk of heart disease, diabetes and the development of precancerous disease of the womb...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29106989/gonadal-hormones-affect-alcohol-drinking-but-not-cue-yohimbine-induced-alcohol-seeking-in-male-and-female-rats
#19
Megan L Bertholomey, Mary M Torregrossa
Alcohol use disorder (AUD) is a chronic, relapsing disease characterized by maladaptive patterns of alcohol drinking and seeking. Though sex differences exist in the etiology of AUD, much remains to be elucidated concerning the mechanisms underlying sex-related vulnerability to developing excessive alcohol-motivated behavior. While a large body of evidence points to an important role of circulating gonadal hormones in mediating cocaine reinforcement, findings are less consistent with respect to ethanol. Critically, the effects of gonadal hormones on the reinstatement of ethanol seeking, a model of "craving"-like behavior that reveals pronounced sex differences, has not yet been examined...
October 26, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29100822/-which-ovarian-stimulation-to-which-women-the-polycystic-ovary-syndrome-pcos
#20
P Merviel, S Bouée, M Ménard, M-T Le Martelot, S Roche, C Lelièvre, J-J Chabaud, C Jacq, H Drapier, D Beauvillard
Polycystic ovarian syndrome (PCOS) is a frequent pathology in the young woman, linking infertility to a metabolic disease. Initial support will include a plan (in the case of overweight or obesity) to lose at least 5 to 10% of the weight. Subsequently, clomiphene citrate is the first treatment for ovulation induction with pregnancy rates of 40 to 80% after 6 cycles. If there is resistance to clomiphene citrate, the choice will be between the ovarian drilling (50-60% of pregnancy in the year following, including the half spontaneous) or ovarian stimulation with gonadotropins...
October 31, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
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