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Biology of natriuretic peptides

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https://www.readbyqxmd.com/read/27871468/increased-levels-of-soluble-corin-in-pre-eclampsia-and-fetal-growth-restriction
#1
Jun Miyazaki, Haruki Nishizawa, Asuka Kambayashi, Mayuko Ito, Yoshiteru Noda, Sumire Terasawa, Takema Kato, Hironori Miyamura, Kazuya Shiogama, Takao Sekiya, Hiroki Kurahashi, Takuma Fujii
Atrial natriuretic peptide is biologically activated by the atrial natriuretic peptide-converting enzyme, corin, and has an important role in regulating blood pressure. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction (FGR) without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. CORIN mRNA levels were not elevated in placentas from pre-eclampsia or unexplained FGR cases...
December 2016: Placenta
https://www.readbyqxmd.com/read/27869886/-anmco-elas-sibioc-consensus-document-recommendations-for-the-use-of-cardiac-biomarkers-in-heart-failure-patients
#2
Nadia Aspromonte, Michele Massimo Gulizia, Aldo Clerico, Giuseppe Di Tano, Michele Emdin, Mauro Feola, Massimo Iacoviello, Roberto Latini, Andrea Mortara, Roberto Valle, Gianfranco Misuraca, Claudio Passino, Serge Masson, Alberto Aimo, Marcello Ciaccio, Marco Migliardi
Biomarkers have dramatically impacted the way heart failure (HF) patients are evaluated and managed. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological or pathogenic processes, or pharmacological responses to a therapeutic intervention. Natriuretic peptides (B-type natriuretic peptide [BNP] and N-terminal proBNP) are the gold standard biomarkers in determining the diagnosis and prognosis of HF, and a natriuretic peptide-guided HF management looks promising...
September 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/27804880/snake-venom-peptides-and-low-mass-proteins-molecular-tools-and-therapeutic-agents
#3
J R Almeida L M Resende, R K Watanabe, V C Corassola, S Huancahuire-Vega, C A da S Caldeira, A Coutinho-Neto, A M Soares, N Vale, P A de C Gomes, S Marangoni, L de A Calderon, S L Da Silva
Snake venoms are natural sources of biologically active molecules that are able to act selectively and specifically on different cellular targets, modulating physiological functions. Thus, these mixtures, composed mainly of proteins and peptides, provide ample and challenging opportunities and a diversified molecular architecture to design and develop tools and agents of scientific and therapeutic interest. Among these components, peptides and small proteins play diverse roles in numerous physiological processes, exerting a wide range of pharmacological activities, such as antimicrobial, antihypertensive, analgesic, antitumor, analgesic, among others...
October 28, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27760526/n-terminal-pro-brain-natriuretic-peptide-levels-associated-with-severe-hand-foot-and-mouth-disease
#4
Hui-Ling Deng, Yu-Feng Zhang, Ya-Ping Li, Yu Zhang, Yan Xie, Jun Wang, Xiao-Yan Wang, Shuang-Suo Dang
BACKGROUND: Severe hand, foot, and mouth disease (HFMD) is sometimes associated with serious complications such as acute heart failure that can cause substantial child mortality. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive and specific biomarker of congestive heart failure. The aim of this study was to use plasma NT-proBNP levels to establish the severity of childhood HFMD. METHODS: A retrospective study was performed in 128 Chinese patients with severe HFMD and 88 patients with mild HFMD treated between January 2014 and October 2015...
October 19, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27754186/sp-04-1-the-role-of-natriuretic-peptides-in-the-pathogenesis-of-cardiovascular-diseases
#5
Zhanna Kobalava
The burden of cardiovascular diseases (CVD) in general and heart failure (HF) in particular continues to increase worldwide. CVD are major contributors to death and morbidity and recognized as important drivers of healthcare expenditure. Chronic overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in human hypertension and HF pathophysiology. RAAS is fundamental in the overall regulation of cardiovascular homeostasis through the actions of hormones, which regulate vascular tone, and specifically blood pressure through vasoconstriction and renal sodium and water retention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753992/ed-05-4-natriuretic-peptides-metabolic-syndrome-and-hypertension-an-integrated-view
#6
Riccardo Sarzani
Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are the cardiac natriuretic peptides (NP), true "cardiometabolic" hormones well known for their renal, endocrine and cardiovascular activities leading to reduced sodium reabsorption and arterial blood pressure. These effects are mainly mediated by the second messenger cGMP that also stimulates lipolysis, mitochondriogenesis and a thermogenic program with potency similar to catecholamines. Two distinct NP receptors modulate the final response to cardiac NP: the cGMP-signaling receptor NPRA and the clearance receptor NPRC...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749683/associations-between-psychological-constructs-and-cardiac-biomarkers-after-acute-coronary-syndrome
#7
Christopher M Celano, Eleanor E Beale, Scott R Beach, Arianna M Belcher, Laura Suarez, Shweta R Motiwala, Parul U Gandhi, Hanna Gaggin, James L Januzzi, Brian C Healy, Jeff C Huffman
OBJECTIVE: Psychological constructs are associated with cardiovascular health, but the biological mechanisms mediating these relationships are unknown. We examined relationships between psychological constructs and markers of inflammation, endothelial function, and myocardial strain in a cohort of post-acute coronary syndrome (ACS) patients. METHODS: Participants (N = 164) attended study visits 2 weeks and 6 months after ACS. During these visits, they completed self-report measures of depressive symptoms, anxiety, optimism, and gratitude; and blood samples were collected for measurement of biomarkers reflecting inflammation, endothelial function, and myocardial strain...
September 30, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27712087/development-and-validation-of-an-ia-lc-ms-method-to-quantitate-active-and-total-b-type-natriuretic-peptide-in-human-plasma
#8
Derek L Chappell, Anita Yh Lee, Harold S Bernstein, Michael E Lassman, Omar F Laterza
AIM: Patients with elevated levels of B-type natriuretic peptide (BNP) and/or NT-proBNP as measured by clinical tests have an elevated risk of heart failure (HF). Despite utility in large clinical studies, both assays are plagued by large biological variability and specificity issues. To address these concerns and further investigate BNP in the HF setting, we developed an LC/MS assay to characterize the ratio of active to total BNP. RESULTS: We have developed and validated a novel immunoaffinity LC/MS assay to measure BNP-derived fragments, as well as 'total BNP' in human plasma...
October 7, 2016: Bioanalysis
https://www.readbyqxmd.com/read/27686019/neprilysin-inhibitors-emerging-therapy-for-heart-failure
#9
Anjali Tiku Owens, Susan Brozena, Mariell Jessup
Biologically active natriuretic peptides (NPs) are an integral part of cardiac homeostasis as they help to maintain sodium and fluid balance. When homeostasis is perturbed by neurohormonal activation in heart failure, levels of NPs rise in response. Neprilysin (NEP) is a naturally occuring enzyme that breaks down NPs. Scientists have recently discovered a novel pharmacologic agent that combines a NEP inhibitor and an angiotensin receptor blocker. In a large clinical trial, this new drug was found to reduce hospitalization and mortality in systolic heart failure...
September 21, 2016: Annual Review of Medicine
https://www.readbyqxmd.com/read/27683422/biomarkers-beyond-the-natriuretic-peptides-for-chronic-heart-failure-galectin-3-and-soluble-st2
#10
Alan H B Wu
B-type natriuretic peptide (BNP) and NT-proBNP are widely used plasma biomarkers for the diagnosis of acute decompensated heart failure and prognosis for future cardiac disease. The clinical performance of these tests for management of chronic heart failure is somewhat limited by the markers' high biological variation. Biomarkers such as galectin-3 and soluble ST2 that reflect ongoing remodeling via cardiac fibrosis of the heart may provide complementary information to the natriuretic peptides in the management of chronic heart failure with regards to risk stratification for future adverse cardiac events (death, myocardial infarction, and need for heart transplantation)...
October 2012: EJIFCC
https://www.readbyqxmd.com/read/27643143/sp-04-1-the-role-of-natriuretic-peptides-in-the-pathogenesis-of-cardiovascular-diseases
#11
Zhanna Kobalava
The burden of cardiovascular diseases (CVD) in general and heart failure (HF) in particular continues to increase worldwide. CVD are major contributors to death and morbidity and recognized as important drivers of healthcare expenditure. Chronic overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in human hypertension and HF pathophysiology. RAAS is fundamental in the overall regulation of cardiovascular homeostasis through the actions of hormones, which regulate vascular tone, and specifically blood pressure through vasoconstriction and renal sodium and water retention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642903/ed-05-4-natriuretic-peptides-metabolic-syndrome-and-hypertension-an-integrated-view
#12
Riccardo Sarzani
Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are the cardiac natriuretic peptides (NP), true "cardiometabolic" hormones well known for their renal, endocrine and cardiovascular activities leading to reduced sodium reabsorption and arterial blood pressure. These effects are mainly mediated by the second messenger cGMP that also stimulates lipolysis, mitochondriogenesis and a thermogenic program with potency similar to catecholamines. Two distinct NP receptors modulate the final response to cardiac NP: the cGMP-signaling receptor NPRA and the clearance receptor NPRC...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638782/hydrogen-sulfide-regulates-kr%C3%A3-ppel-like-factor-5-transcription-activity-via-specificity-protein-1-s-sulfhydration-at-cys664-to-prevent-myocardial-hypertrophy
#13
Guoliang Meng, Yujiao Xiao, Yan Ma, Xin Tang, Liping Xie, Jieqiong Liu, Yue Gu, Ying Yu, Chung-Min Park, Ming Xian, Xin Wang, Albert Ferro, Rui Wang, Philip K Moore, Zhiren Zhang, Hong Wang, Yi Han, Yong Ji
BACKGROUND: Hydrogen sulfide (H2S) is a gasotransmitter that regulates multiple cardiovascular functions. Krüppel-like factor 5 (KLF5) exerts diverse functions in the cardiovascular system. Whether and how H2S regulates KLF5 in myocardial hypertrophy is unknown. METHODS AND RESULTS: In our study, hypertrophic myocardial samples in the clinic were collected and underwent histological and molecular biological analysis. Spontaneously hypertensive rats and neonatal rat cardiomyocytes were studied for functional and signaling responses to GYY4137, an H2S-releasing compound...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27508823/-op-7b-04-up-regulation-of-the-natriuretic-peptide-clearance-receptor-and-inhibition-of-lipolysis-by-insulin-filling-the-gap-between-metabolic-syndrome-and-hypertension
#14
M Bordicchia, M Ceresiani, M Pavani, R Sarzani
OBJECTIVE: Natriuretic peptides (NP), ANP and BNP, regulate not only the homeostasis of the cardiovascular system but also lipid metabolism in adipocytes by promoting lipolysis and thermogenesis. NP circulating levels and therefore their systemic effects are largely dependent on the expression ratio between NPRA (principal biologically active receptor) and NPRC (clearance receptor). Adipocytes affect NP levels and their cardio-renal effects through the expression of NPRC. AIM: To evaluate the role of insulin and ANP on lipolysis, looking for a common mechanism underlying the metabolic syndrome and hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27496203/hypoxia-exposure-and-b-type-natriuretic-peptide-release-from-langendorff-heart-of-rats
#15
K Anttila, T Streng, J Pispa, M Vainio, M Nikinmaa
AIM: We studied if available oxygen without induced mechanical stretch regulates the release of the biologically active B-type natriuretic peptide (BNP) from Langendorff heart. METHODS: Rat hearts were isolated and perfused with a physiological Krebs-Henseleit solution at a constant hydrostatic pressure in Langendorff setup. The basal O2 level of perfusate (24.4±0.04 mg L(-1) ) was gradually lowered to 3.0±0.01 mg L(-1) over 20 minutes using N2 gas (n=7). BNP and O2 level were measured from coronary flow...
August 6, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27447810/brain-natriuretic-peptide-much-more-than-a-biomarker
#16
REVIEW
Luigino Calzetta, Augusto Orlandi, Clive Page, Paola Rogliani, Barbara Rinaldi, Giuseppe Rosano, Mario Cazzola, Maria Gabriella Matera
Brain natriuretic peptide (BNP) modulates several biological processes by activating the natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases natriuresis, diuresis and vasodilatation, thus resulting in a decreased cardiac workload. BNP and NT-proBNP, which is the biologically inactive N-terminal portion of its pro-hormone, are fast and sensitive biomarkers for diagnosing heart failure. The plasma concentrations of both BNP and NT-proBNP also correlate with left ventricular function in patients with acute exacerbation of COPD, even without history of heart failure...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27422885/oocyte-maturation-and-quality-role-of-cyclic-nucleotides
#17
REVIEW
R B Gilchrist, A M Luciano, D Richani, H T Zeng, X Wang, M De Vos, S Sugimura, J Smitz, F J Richard, J G Thompson
The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades, and many of the long-standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP - inhibiting the hydrolysis of intra-oocyte cAMP - and that the pre-ovulatory gonadotrophin surge reverses these processes...
November 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27419272/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-ii-neurochemistry-neurophysiology-and-neurocognition
#18
Borwin Bandelow, David Baldwin, Marianna Abelli, Blanca Bolea-Alamanac, Michel Bourin, Samuel R Chamberlain, Eduardo Cinosi, Simon Davies, Katharina Domschke, Naomi Fineberg, Edna Grünblatt, Marek Jarema, Yong-Ku Kim, Eduard Maron, Vasileios Masdrakis, Olya Mikova, David Nutt, Stefano Pallanti, Stefano Pini, Andreas Ströhle, Florence Thibaut, Matilde M Vaghi, Eunsoo Won, Dirk Wedekind, Adam Wichniak, Jade Woolley, Peter Zwanzger, Peter Riederer
OBJECTIVE: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
July 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27382803/-adrenomedullin-in-the-kidney-physiology-and-pathophysiology
#19
REVIEW
Miguel Eduardo Sogbe-Díaz, Emilia Elena Díaz-López
Adrenomedullin (AM) is a potent vasodilatory 52-aminoacid peptide hormone, ubiquitous with multiple physiological effects which contribute to homeostatic responses. Significantly, it is distributed in the adrenal gland, lung, cardiovascular and renal system. The biological effects of AM are directly mediated by specific receptors as heterodimers composed of the calcitonin-receptor-like receptor (CLR) and one of two receptor activity modifying proteins (RAMP2 or RAMP3). The CLR/RAMP2 (AM1 receptor) is more highly AM-specific than The CLR/RAMP3 (AM2 receptor)...
March 2016: Investigación Clínica
https://www.readbyqxmd.com/read/27363651/protective-effects-of-naringenin-in-cardiorenal-syndrome
#20
Yan Liu, Wenjun An, Aibao Gao
BACKGROUND: Cardiorenal syndrome is a complicated and bidirectional interrelationship between the heart and kidneys. Naringenin (NG) is a naturally occurring flavonoid possessing various biological and pharmacological properties. MATERIALS AND METHODS: We tested whether NG could improve cardiac and renal function in a rat model of cardiorenal syndrome. RESULTS: The results showed that NG-attenuated cardiac remodeling and cardiac dysfunction in rats with cardiorenal syndrome, as evidenced by decrease of left ventricle weight (LVW), increase of body weight (BW), decrease of LVW/BW, decrease of concentrations of serum creatinine, blood urea nitrogen, type-B natriuretic peptide, aldosterone, angiotensin (Ang) II, C-reactive protein, and urine protein, increase of left ventricular systolic pressure and falling rates of left ventricular pressure (dp/dtmax), and decrease of left ventricular diastolic pressure, left ventricular end-diastolic pressure, and -dp/dtmax...
June 15, 2016: Journal of Surgical Research
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