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Biology of natriuretic peptides

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https://www.readbyqxmd.com/read/29432202/plasma-midregional-proadrenomedullin-mr-proadm-concentrations-and-their-biological-determinants-in-a-reference-population
#1
Magdalena Krintus, Marek Kozinski, Federica Braga, Jacek Kubica, Grazyna Sypniewska, Mauro Panteghini
BACKGROUND: Midregional proadrenomedullin (MR-proADM) is emerging as a prognostic biomarker for detecting the failure of multiple organs. Establishment of scientifically robust reference intervals facilitates interpretation of laboratory test results. The objectives of this study were (i) to establish reliable reference intervals for plasma MR-proADM using a commercially available automated fluoroimmunoassay in apparently healthy individuals, and (ii) to identify biological determinants of MR-proADM concentrations...
February 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29411335/evolving-role-of-natriuretic-peptides-from-diagnostic-tool-to-therapeutic-modality
#2
Ines Pagel-Langenickel
Natriuretic peptides (NP) are widely recognized as key regulators of blood pressure, water and salt homeostasis. In addition, they play a critical role in physiological cardiac growth and mediate a variety of biological effects including antiproliferative and anti-inflammatory effects in other organs and tissues. The cardiac release of NPs ANP and BNP represents an important compensatory mechanism during acute and chronic cardiac overload and during the pathogenesis of heart failure where their actions counteract the sustained activation of renin-angiotensin-aldosterone and other neurohormonal systems...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29401264/stretch-induced-compliance-a-novel-adaptive-biological-mechanism-following-acute-cardiac-load
#3
André M Leite-Moreira, João Almeida-Coelho, João S Neves, Ana L Pires, João Ferreira-Martins, Ricardo Castro-Ferreira, Ricardo Ladeiras-Lopes, Glória Conceição, Daniela Miranda-Silva, Patrícia Rodrigues, Nazha Hamdani, Melissa Herwig, Inês Falcão-Pires, Walter J Paulus, Wolfgang A Linke, André P Lourenço, Adelino F Leite-Moreira
Aims: The heart is constantly challenged with acute bouts of stretching or overload. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying mechanisms. Methods and Results: Left ventricles (LV) of intact rat hearts, rabbit papillary muscles and myocardial strips from cardiac surgery patients were stretched. After stretching, there was a sustained >40% decrease in end-diastolic pressure (EDP) or passive tension (PT) for 15 minutes in all species and experimental preparations...
February 1, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29353438/examination-of-pituitary-adenylate-cyclase-activating-polypeptide-pacap-as-a-potential-biomarker-in-heart-failure-patients
#4
Zsolt Sarszegi, Dora Szabo, Balazs Gaszner, Attila Konyi, Dora Reglodi, Jozsef Nemeth, Beata Lelesz, Beata Polgar, Adel Jungling, Andrea Tamas
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated its cardioprotective effects in vitro and in various animal models. However, few data are available on the presence of PACAP in human cardiac tissues and its role in the pathomechanism and progression of different cardiac disorders, particularly heart failure...
January 20, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29347987/determinants-of-long-term-outcome-in-icu-survivors-results-from-the-frog-icu-study
#5
Etienne Gayat, Alain Cariou, Nicolas Deye, Antoine Vieillard-Baron, Samir Jaber, Charles Damoisel, Qin Lu, Xavier Monnet, Isabelle Rennuit, Elie Azoulay, Marc Léone, Heikel Oueslati, Bertrand Guidet, Diane Friedman, Antoine Tesnière, Romain Sonneville, Philippe Montravers, Sébastien Pili-Floury, Jean-Yves Lefrant, Jacques Duranteau, Pierre-François Laterre, Nicolas Brechot, Karine Chevreul, Morgane Michel, Bernard Cholley, Matthieu Legrand, Jean-Marie Launay, Eric Vicaut, Mervyn Singer, Matthieu Resche-Rigon, Alexandre Mebazaa
BACKGROUND: Intensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge. METHODS: FROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium...
January 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29305560/heart-failure-with-preserved-ejection-fraction-controversies-challenges-and-future-directions
#6
REVIEW
Rosita Zakeri, Martin R Cowie
Heart failure with preserved ejection fraction (HFpEF) comprises almost half of the population burden of HF. Because HFpEF likely includes a range of cardiac and non-cardiac abnormalities, typically in elderly patients, obtaining an accurate diagnosis may be challenging, not least due to the existence of multiple HFpEF mimics and a newly identified subset of patients with HFpEF and normal plasma natriuretic peptide concentrations. The lack of effective treatment for these patients represents a major unmet clinical need...
March 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29206329/cardiac-tissue-regeneration-a-preliminary-study-on-carbon-based-nanotubes-gelatin-scaffold
#7
Manuela Cabiati, Federico Vozzi, Federica Gemma, Francesca Montemurro, Carmelo De Maria, Giovanni Vozzi, Claudio Domenici, Silvia Del Ry
The aim of this study was set-up and test of gelatin and carbon nanotubes scaffolds. Gelatin-based (5%) genipin cross-linked (0.2%) scaffolds embedding single-walled carbon nanotubes (SWCNTs, 0.3, 0.5, 0.7, 0.9, and 1.3% w/w) were prepared and mechanically/electrically characterized. For biological evaluation, H9c2 cell line was cultured for 10 days. Cytotoxicity, cell growth and differentiation, immunohistochemistry, and real-time PCR analysis were performed. Myoblast and cardiac differentiation were obtained by serum reduction to 1% (C1% ) and stimulation with 50 nM all trans-retinoic acid (CRA ), respectively...
December 5, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29200910/comparative-effects-of-angiotensin-ii-and-angiotensin-4-8-on-blood-pressure-and-anp-secretion-in-rats
#8
Hoang Thi Ai Phuong, Lamei Yu, Byung Mun Park, Suhn Hee Kim
Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different biological effects but it remains unknown whether Ang-(4-8) is an active peptide. The present study was to investigate the effects of Ang-(4-8) on hemodynamics and atrial natriuretic peptide (ANP) secretion using isolated beating rat atria. Atrial stretch caused increases in atrial contractility by 60% and in ANP secretion by 70%...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29198760/impact-of-long-distance-rowing-on-biological-health-a-pilot-study
#9
Miguel A Frias, Julien Virzi, Olivier Golaz, Baris Gencer, François Mach, Nicolas Vuilleumier
OBJECTIVES: To determine the impact of long distance rowing (160km, nonstop) on standard biological parameters and to study the relation between inflammation, myocardial necrosis, lipid profile, heart rate and energy expenditure. METHODS: Electrolytes, lipid profile, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), procalcitonin (PCT), high-sensitive troponin T (hs-cTnT), and N-terminal pro-brain natriuretic peptide (NT-proBNP), were measured on non-fasting venous blood samples collected 8h before and after the rowing race on five healthy competitors...
November 30, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29197198/cardiovascular-disease-risk-factors-in-patients-with-posttraumatic-stress-disorder-ptsd-a-narrative-review
#10
Marina Šagud, Nenad Jakšić, Bjanka Vuksan-Ćusa, Mladen Lončar, Ivana Lončar, Alma Mihaljević Peleš, Davor Miličić, Miro Jakovljević
Posttraumatic stress disorder (PTSD) is a chronic condition related to severe stress and trauma. There is a mounting evidence about increased prevalence and mortality from cardiovascular diseases (CVD) in patients with PTSD. This review summarizes the current data on possible relations between PTSD and increased risks of CVD, including biological, psychological and behavioral factors. Biological factors refer to increased prevalence of metabolic syndrome (MetS), hypertension, elevation of pro-inflammatory cytokines and homocysteine levels...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29177058/biomarkers-of-cardiovascular-stress-and-fibrosis-in-preclinical-hypertrophic-cardiomyopathy
#11
Jennifer E Ho, Ling Shi, Sharlene M Day, Steven D Colan, Mark W Russell, Jeffrey A Towbin, Mark V Sherrid, Charles E Canter, John Lynn Jefferies, Anne Murphy, Matthew Taylor, Luisa Mestroni, Allison L Cirino, Lynn A Sleeper, Peter Jarolim, Begoña Lopez, Arantxa Gonzalez, Javier Diez, E John Orav, Carolyn Y Ho
Objective: Sarcomeric gene mutation carriers without overt left ventricular hypertrophy (G+/LVH-) can harbour subclinical changes in cardiovascular structure and function that precede the development of hypertrophic cardiomyopathy (HCM). We sought to investigate if circulating biomarkers of cardiovascular stress and collagen metabolism among G+/LVH- individuals, measured at rest and following exercise provocation, yield further insights into the underlying biology of HCM. Methods: We studied 76 individuals with overt HCM, 50 G+/LVH- individuals and 41 genotype-negative related controls enrolled in a cross-sectional, multicentre observational study (HCMNet)...
2017: Open Heart
https://www.readbyqxmd.com/read/29154956/biomarkers-in-mitral-regurgitation
#12
REVIEW
Magnus Bäck, Rodolfo Pizarro, Marie-Annick Clavel
Mitral regurgitation (MR) is a common cause of heart failure but may also remain silent without either symptoms or altered cardiac function. In the latter case, management is still controversial and biomarkers could be an important means to solving remaining issues in MR management. As objective markers of myocardial stress and early left ventricular dysfunction, biomarkers may for example facilitate the identification of patients with benefit from early surgery of degenerative MR. The most studied biomarkers are the natriuretic peptides (NPs), especially brain NP, as well as its N terminal prohormone...
November 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29140729/gene-expression-and-gene-associations-during-the-development-of-heart-failure-with-preserved-ejection-fraction-in-the-dahl-salt-sensitive-model-of-hypertension
#13
Jeffrey Yim, Hyokeun Cho, Simon W Rabkin
Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9...
November 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29101624/genistein-attenuates-pathological-cardiac-hypertrophy-in-vivo-and-in-vitro
#14
Y Meng, Y Zhang, Z Ma, H Zhou, J Ni, H Liao, Q Tang
BACKGROUND: We investigated the effects and underlying mechanisms of genistein on pathological cardiac hypertrophy in vivo and in vitro. MATERIALS AND METHODS: A cardiac hypertrophy model was developed by aortic banding (AB). C57/BL6 mice were randomly assigned to sham + vehicle (CON), sham + genistein (GEN), AB + vehicle (AB), and AB + genistein groups. Genistein (40 mg/kg/day) was administered by gavage for 7 weeks. After assessing the echocardiographic and hemodynamic parameters, mouse hearts were harvested for histopathological and molecular biological analysis...
November 3, 2017: Herz
https://www.readbyqxmd.com/read/29062197/n-terminal-pro-brain-natriuretic-peptides-in-dogs-and-cats-a-technical-and-clinical-review
#15
REVIEW
Gabriela Vieira de Lima, Felipp da Silveira Ferreira
Biomarkers are quantitative indicators of biological processes performed by an organ or system. In recent years, natriuretic peptides (NPs) have emerged as important tools in the diagnosis and therapeutic monitoring of heart diseases. Research has shown that serum and plasma levels of N-terminal pro brain NP (NT-proBNP) in dogs and cats are the only biomarkers that afford to diagnose and monitor congestive processes and, indirectly, the myocardial function of small animals. The present review discusses the peer-reviewed specialized literature about NT-proBNP and presents and compares the potential clinical applications of this NP in veterinary medicine of small animals, considering diagnosis, follow-up, and prognosis of myocardial or systemic diseases...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29046682/cyclic-nucleotide-monophosphates-and-their-cyclases-in-plant-signaling
#16
REVIEW
Chris Gehring, Ilona S Turek
The cyclic nucleotide monophosphates (cNMPs), and notably 3',5'-cyclic guanosine monophosphate (cGMP) and 3',5'-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense. At the single molecule level, we are now beginning to understand how cNMPs modify specific target molecules such as cyclic nucleotide-gated channels, while at the systems level, a recent study of the Arabidopsis cNMP interactome has identified novel target molecules with specific cNMP-binding domains...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29040610/the-biological-impact-of-blood-pressure-associated-genetic-variants-in-the-natriuretic-peptide-receptor-c-gene-on-human-vascular-smooth-muscle
#17
Meixia Ren, Fu Liang Ng, Helen Warren, Kate Witkowska, Michael Baron, Zhilong Jia, Claudia Cabrera, Ruoxin Zhang, Borbala Mifsud, Patricia B Munroe, Qingzhong Xiao, Andrea Townsend-Nicholson, Adrian Hobbs, Shu Ye, Mark Caulfield
Elevated blood pressure (BP) is a major global risk factor for cardiovascular disease. Genome-wide association studies have identified several genetic variants at the NPR3 locus associated with BP, but the functional impact of these variants remains to be determined. Here we confirmed, by a genome-wide association study within UK Biobank, the existence of two independent BP-related signals within NPR3 locus. Using human primary vascular smooth muscle cells and endothelial cells from different individuals, we found that the BP-elevating alleles within one linkage disequilibrium block identified by the sentinel variant rs1173771 was associated with lower endogenous NPR3 mRNA and protein levels in vascular smooth muscle cells, together with reduced levels in open chromatin and nuclear protein binding...
October 10, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28987949/zingiberis-rhizoma-mediated-enhancement-of-the-pharmacological-effect-of-aconiti-lateralis-radix-praeparata-against-acute-heart-failure-and-the-underlying-biological-mechanisms
#18
Lu Zhang, Xiaohua Lu, Jiabo Wang, Pengyan Li, Haotian Li, Shizhang Wei, Xuelin Zhou, Kun Li, Lifu Wang, Ruilin Wang, Yanling Zhao, Xiaohe Xiao
Aconiti Lateralis Radix Praeparata (Fuzi), a type of Chinese materia medica, has been used to treat acute and chronic heart failure (HF) in traditional Chinese medicine and has been proven in numerous animal studies. It is also well-known that Zingiberis Rhizoma (Ganjiang) is ineffective in the treatment of HF, but it can enhance the anti-HF effect of Fuzi. However, the mechanism underlying this compatibility is still not well investigated. To investigate this mechanism, a model of acute heart failure (AHF) in SD rats induced by propafenone hydrochloride was established in this study...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28985241/short-term-high-salt-diet-increases-corin-level-to-regulate-the-salt-water-balance-in-humans-and-rodents
#19
Jiao Zhang, Yanjun Yin, Lili Chen, Chao Chu, Yang Wang, Yongbo Lv, Ming He, Marcy Martin, Po-Hsun Huang, Jian-Jun Mu, John Y-J Shyy, Zu-Yi Yuan
Background: Dietary sodium and potassium affect the fluctuation in blood pressure and renal function. Corin, with its enzymatic activity to convert pro-atrial natriuretic peptide (pro-ANP) to biologically active ANP, regulates blood pressure, cardiac and renal functions. We investigated whether corin expression responds to a high-salt (HS) diet to regulate salt and water balance. Methods and results: Forty-two volunteers followed 3 sequential diets for 7 days each: a low-salt (LS) diet (3...
August 8, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28861997/profiling-b-type-natriuretic-peptide-cleavage-peptidoforms-in-human-plasma-by-capillary-electrophoresis-with-electrospray-ionization-mass-spectrometry
#20
Shenyan Zhang, Koen Raedschelders, Marcia Santos, Jennifer E Van Eyk
B-type Natriuretic Peptide (BNP) is a biologically active circulating hormone. Plasma concentrations of BNP are routinely used in the diagnosis of heart failure, and the intravenous infusion of recombinant BNP can be used for heart failure treatment. Like many bioactive polypeptides, multiple plasma enzymes are known to cleave circulating BNP, and as part of the CVD-B/D-HPP mandate, we sought to develop a technique capable of profiling these catabolic processes in plasma. We used a neutral-coated capillary electrophoresis-electrospray ionization (CESI) separation system coupled with high-resolution mass spectrometry to profile the proteolysis of exogenous recombinant BNP1-32 in plasma...
October 2, 2017: Journal of Proteome Research
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