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PROTECT TRIAL 2011

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https://www.readbyqxmd.com/read/28544101/belatacept-combined-with-transient-calcineurin-inhibitor-therapy-prevents-rejection-and-promotes-improved-long-term-renal-allograft-function
#1
A B Adams, J Goldstein, C Garrett, R Zhang, R E Patzer, K A Newell, N A Turgeon, A S Chami, A Guasch, A D Kirk, S O Pastan, T C Pearson, C P Larsen
Belatacept, a T cell costimulation-blocker demonstrated superior renal function, lower cardiovascular risk, and improved graft/patient survival in renal transplant recipients. Despite the potential benefits, adoption of belatacept has been limited in part due to concerns regarding higher rates and grades of acute rejection in clinical trials. Since July 2011 we have utilized belatacept-based immunosuppression regimens in clinical practice. In this retrospective analysis of 745 patients undergoing renal transplantation at our center, we compared patients treated with belatacept (n=535) to a historical cohort receiving a tacrolimus-based protocol (n=205)...
May 23, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28543165/recognition-of-early-mortality-in-multiple-myeloma-by-a-prediction-matrix
#2
Howard Terebelo, Shankar Srinivasan, Mohit Narang, Rafat Abonour, Cristina Gasparetto, Kathleen Toomey, James W Hardin, Gail Larkins, Amani Kitali, Robert M Rifkin, Jatin J Shah
Early mortality (EM; death ≤ 6 months from diagnosis) has been reported in several newly diagnosed multiple myeloma (NDMM) trials. Before the era of novel agents, the incidence was 10%-14%. Causes of death included infections/pneumonia, renal failure, refractory disease, and cardiac events. Staging systems, such as the revised International Staging System (r-ISS), and prognostic factors including cytogenetics, lactate dehydrogenase levels, and myeloma-specific factors, are useful to assess overall prognosis; however, they cannot predict EM...
May 24, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28533053/exploring-evidence-for-behavioral-risk-compensation-among-participants-in-an-hiv-vaccine-clinical-trial
#3
Julia E Painter, Ralph J DiClemente, Lauren Jimenez, Theron Stuart, Jessica M Sales, Mark J Mulligan
BACKGROUND: HIV vaccine trial participants may engage in behavioral risk compensation due to a false sense of protection. We conducted an ancillary study of an HIV Vaccine Trials Network (HVTN) vaccine efficacy trial to explore risk compensation among trial participants compared to persons who were willing to participate but ineligible based on previous exposure to the Ad5 virus (Ad5+) across three timepoints. METHODS: Participants were drawn from the Atlanta, GA site of the HVTN 505 vaccine trial...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28513876/the-inter-play-between-facilitation-and-context-in-the-promoting-action-on-research-implementation-in-health-services-framework-a-qualitative-exploratory-implementation-study-embedded-in-a-cluster-randomised-controlled-trial-to-reduce-restraint-in-nursing-homes
#4
Tone Elin Mekki, Christine Øye, Bodil Margrete Kristensen, Helen Dahl, Astrid Haaland, Kristin Aas Nordin, Marta R Strandos, Toril Marie Terum, Arnt Egil Ydstebø, Brendan Mccormack
AIM: To explore the inter-play between external facilitation and nursing home contexts relative to intervention outcomes. BACKGROUND: The Promoting Action on Research Implementation in Health Services framework is frequently used to theoretically inform implementation and research in nursing and recent reviews indicate high face validity for health services. However, the inter-play and relationship between framework sub- elements of evidence, context and facilitation and the prospective utility in non-English speaking contexts warrant further illumination...
May 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28494067/association-of-dietary-vitamin-k1-intake-with-the-incidence-of-cataract-surgery-in-an-adult-mediterranean-population-a-secondary-analysis-of-a-randomized-clinical-trial
#5
María L Camacho-Barcia, Mònica Bulló, Jesús F Garcia-Gavilán, Miguel Ruiz-Canela, Dolores Corella, Ramón Estruch, Montserrat Fitó, Alfredo García-Layana, Fernando Arós, Miquel Fiol, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Ana García-Arellano, Ernest Vinyoles, José Vicente Sorli, Jordi Salas-Salvadó
Importance: Cataract, one of the most frequent causes of blindness in developed countries, is strongly associated with aging. The exact mechanisms underlying cataract formation are still unclear, but growing evidence suggests a potential role of inflammatory and oxidative processes. Therefore, antioxidant and anti-inflammatory factors of the diet, such as vitamin K1, could play a protective role. Objective: To examine the association between dietary vitamin K1 intake and the risk of incident cataracts in an elderly Mediterranean population...
May 11, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28480799/the-relationship-between-employment-status-and-depression-symptomatology-among-women-at-risk-for-postpartum-depression
#6
Beth A Lewis, Lauren Billing, Katie Schuver, Dwenda Gjerdingen, Melissa Avery, Bess H Marcus
Approximately 13%-19% of new mothers report depression during the postpartum period. Returning to work after childbirth is associated with depression; however, it is unclear if this finding applies to women who are at high risk for postpartum depression. The purpose of this study was to examine the relationship between employment status and depression symptomatology among women at risk for postpartum depression (defined as personal or maternal history of depression). This study was a post hoc analysis from a previously conducted randomized controlled trial...
May 1, 2017: Women's Health
https://www.readbyqxmd.com/read/28475278/anticoagulation-bridge-therapy-in-patients-with-atrial-fibrillation-recent-updates-providing-a-rebalance-of-risk-and-benefit
#7
Candice L Garwood, Bianca Korkis, Domenico Grande, Claudia Hanni, Amy Morin, Lynette R Moser
In 2011, we provided a review of clinical updates and controversies surrounding anticoagulation bridge therapy in patients with atrial fibrillation. Since then, options for oral anticoagulation have expanded with the addition of four direct oral anticoagulant (DOAC) agents available in the United States. Nonetheless, vitamin K antagonist (VKA) therapy continues to be the treatment of choice for patients who are poor candidates for a DOAC and for whom bridge therapy remains a therapeutic dilemma. However, bridge therapy for patients taking a VKA remains a therapeutic dilemma...
May 5, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28475248/effectiveness-of-an-evidence-based-induction-therapy-protocol-revision-in-adult-kidney-transplant-recipients
#8
Jillian P Casale, Dave J Taber, Carmelina Staino, Kimberly Boyle, Kelly Covert, Nicole A Pilch, Caitlin Mardis, Holly B Meadows, Kenneth D Chavin, John W McGillicuddy, Prabhakar K Baliga, James N Fleming
STUDY OBJECTIVE: Induction immunosuppression significantly improves graft outcomes following kidney transplantation, but protocols vary among transplant centers due to the lack of data identifying an optimal induction agent. The objective of this study was to assess the effectiveness of an evidence-based protocol change in induction therapy in adult kidney transplant recipients. DESIGN: Retrospective cohort study. SETTING: Large tertiary care academic medical center...
May 5, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28470683/how-healthy-are-the-healthy-volunteers-penetrance-of-nafld-in-the-biomedical-research-volunteer-pool
#9
Varun Takyar, Anand Nath, Andrea Beri, Ahmed M Gharib, Yaron Rotman
INTRODUCTION: Healthy volunteers are crucial for biomedical research. Inadvertent inclusion of subjects with non-alcoholic fatty liver disease (NAFLD) as controls can compromise study validity and subject safety. Given the rising prevalence of NAFLD in the general population, we sought to identify its prevalence and potential impact in volunteers for clinical trials. METHODS: Cross-sectional study of subjects with "Healthy Volunteer" diagnosis between 2011-2015 and no known liver disease...
May 3, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28460021/hypothermia-and-cerebral-protection-strategies-in-aortic-arch-surgery-a-comparative-effectiveness-analysis-from-the-sts-adult-cardiac-surgery-database
#10
Brian R Englum, Xia He, Brian C Gulack, Asvin M Ganapathi, Joseph P Mathew, J Matthew Brennan, T Brett Reece, W Brent Keeling, Bradley G Leshnower, Edward P Chen, Jeffrey P Jacobs, Vinod H Thourani, G Chad Hughes
OBJECTIVES: Hypothermic circulatory arrest is essential to aortic arch surgery, although consensus regarding optimal cerebral protection strategy remains lacking. We evaluated the current use and comparative effectiveness of hypothermia/cerebral perfusion (CP) strategies in aortic arch surgery. METHODS: Using the Society of Thoracic Surgeons Database, cases of aortic arch surgery with hypothermic circulatory arrest from 2011 to 2014 were categorized by hypothermia strategy-deep/profound (D/P; ≤20°C), low-moderate (L-M; 20...
April 29, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28440892/the-effect-of-adult-early-warning-systems-education-on-nurses-knowledge-confidence-and-clinical-performance-a%C3%A2-systematic-review
#11
REVIEW
Mohamad M Saab, Bridie McCarthy, Tom Andrews, Eileen Savage, Frances J Drummond, Nuala Walshe, Mary Forde, Dorothy Breen, Patrick Henn, Jonathan Drennan, Josephine Hegarty
AIMS: This review aims to determine the effect of adult Early Warning Systems education on nurses' knowledge, confidence and clinical performance. BACKGROUND: Early Warning Systems support timely identification of clinical deterioration and prevention of avoidable deaths. Several educational programmes have been designed to help nurses recognize and manage deteriorating patients. Little is known as to the effectiveness of these programmes. DESIGN: Systematic review...
April 25, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28437029/men-s-eating-and-living-meal-study-calgb-70807-alliance-recruitment-feasibility-and-baseline-demographics-of-a-randomized-trial-of-diet-in-men-on-active-surveillance-for-prostate-cancer
#12
J Kellogg Parsons, John P Pierce, James Mohler, Electra Paskett, Sin-Ho Jung, Michael J Morris, Eric Small, Olwen Hahn, Peter Humphrey, John Taylor, James Marshall
OBJECTIVE: To assess the feasibility of performing national, randomized trials of dietary interventions for localized prostate cancer. METHODS: The Men's Eating and Living (MEAL) study (CALGB 70807 [Alliance]) is a phase III clinical trial testing the efficacy of a high-vegetable diet to prevent progression in patients with prostate cancer on active surveillance (AS). Participants were randomized to a validated diet counselling intervention or to a control condition...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28430986/field-trial-performance-of-herculex-xtra-cry34ab1-cry35ab1-and-smartstax-cry34ab1-cry35ab1-cry3bb1-hybrids-and-soil-insecticides-against-western-and-northern-corn-rootworms-coleoptera-chrysomelidae
#13
K D Johnson, L A Campbell, M D Lepping, D M Rule
Western corn rootworm, Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), and northern corn rootworm, Diabrotica barberi Smith and Lawrence (Coleoptera: Chrysomelidae), are important insect pests in corn, Zea mays L. For more than a decade, growers have been using transgenic plants expressing proteins from the bacterium Bacillus thuringiensis (Bt) to protect corn roots from feeding. In 2011, western corn rootworm populations were reported to have developed resistance to Bt hybrids expressing Cry3Bb1 and later found to be cross-resistant to hybrids expressing mCry3A and eCry3...
June 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28419095/effectiveness-of-a-live-oral-human-rotavirus-vaccine-after-programmatic-introduction-in-bangladesh-a-cluster-randomized-trial
#14
RANDOMIZED CONTROLLED TRIAL
K Zaman, David A Sack, Kathleen M Neuzil, Mohammad Yunus, Lawrence H Moulton, Jonathan D Sugimoto, Jessica A Fleming, Ilias Hossain, Shams El Arifeen, Tasnim Azim, Mustafizur Rahman, Kristen D C Lewis, Andrea J Feller, Firdausi Qadri, M Elizabeth Halloran, Alejandro Cravioto, John C Victor
BACKGROUND: Rotavirus vaccines are now globally recommended by the World Health Organization (WHO), but in early 2009 WHO's Strategic Advisory Group of Experts on Immunization reviewed available data and concluded that there was no evidence for the efficacy or effectiveness of a two-dose schedule of the human rotavirus vaccine (HRV; Rotarix) given early at 6 and 10 wk of age. Additionally, the effectiveness of programmatic rotavirus vaccination, including possible indirect effects, has not been assessed in low-resource populations in Asia...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28415135/the-effects-of-enteral-feeding-improvement-massage-efim-on-premature-infants-a-randomized-controlled-trial
#15
Heeyoung Kim, Kyoung Sook Bang
AIMS AND OBJECTIVES: This study was conducted to prove the effects of an enteral feeding improvement massage (EFIM) for premature infants with regard to their feeding, growing, and superior mesenteric blood flow (SMA) blood flow aspect by a randomized control trial. BACKGROUND: Premature infants have feeding-related problems related to eating and absorbing nutrition due of their immature GI function. Studies regarding the effectiveness of premature infants' enteral feeding improvement by tactile stimulation massage are rare...
April 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28388914/effects-of-community-level-bed-net-coverage-on-malaria-morbidity-in-lilongwe-malawi
#16
Veronica Escamilla, Alisa Alker, Leonard Dandalo, Jonathan J Juliano, William C Miller, Portia Kamthuza, Tapiwa Tembo, Gerald Tegha, Francis Martinson, Michael Emch, Irving F Hoffman
BACKGROUND: The protective effect of insecticide-treated bed nets against individual-level malaria transmission is well known, however community-level effects are less understood. Protective effects from community-level bed net use against malaria transmission have been observed in clinical trials, however, the relationship is less clear outside of a controlled research setting. The objective of this research was to investigate the effect of community-level bed net use against malaria transmission outside of a bed net clinical trial setting in Lilongwe, Malawi following national efforts to scale-up ownership of long-lasting, insecticide-treated bed nets...
April 7, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28384523/effectiveness-of-a-pragmatic-school-based-universal-intervention-targeting-student-resilience-protective-factors-in-reducing-mental-health-problems-in-adolescents
#17
Julia Dray, Jenny Bowman, Elizabeth Campbell, Megan Freund, Rebecca Hodder, Luke Wolfenden, Jody Richards, Catherine Leane, Sue Green, Christophe Lecathelinais, Christopher Oldmeadow, John Attia, Karen Gillham, John Wiggers
Worldwide, 10-20% of adolescents experience mental health problems. Strategies aimed at strengthening resilience protective factors provide a potential approach for reducing mental health problems in adolescents. This study evaluated the effectiveness of a universal, school-based intervention targeting resilience protective factors in reducing mental health problems in adolescents. A cluster randomised controlled trial was conducted in 20 intervention and 12 control secondary schools located in socio-economically disadvantaged areas of NSW, Australia...
April 3, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28380246/matched-cohort-study-of-external-cephalic-version-in-women-with-previous-cesarean-delivery
#18
Anish Keepanasseril, Keerthana Anand, Subrahmanian Soundara Raghavan
OBJECTIVE: To evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery. METHODS: A retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011-2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included...
April 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28329432/user-compliance-with-documenting-on-a-track-and-trigger-based-observation-and-response-chart-a-two-phase-multi-site-audit-study
#19
Doug Elliott, Emily Allen, Sharon McKinley, Lin Perry, Christine Duffield, Margaret Fry, Robyn Gallagher, Rick Iedema, Michael Roche
AIMS: To examine user compliance and completeness of documentation with a newly designed Observation and Response Chart and whether a rapid response system call was triggered when clinically indicated. BACKGROUND: Timely recognition and responses to patient deterioration in hospital general wards remains a challenge for health care systems globally. Evaluating practice initiatives to improve recognition and response are required. DESIGN: Two-phase audit...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28322416/effect-of-intensive-vs-moderate-alveolar-recruitment-strategies-added-to-lung-protective-ventilation-on-postoperative-pulmonary-complications-a-randomized-clinical-trial
#20
Alcino Costa Leme, Ludhmila Abrahao Hajjar, Marcia S Volpe, Julia Tizue Fukushima, Roberta Ribeiro De Santis Santiago, Eduardo A Osawa, Juliano Pinheiro de Almeida, Aline Muller Gerent, Rafael Alves Franco, Maria Ignez Zanetti Feltrim, Emília Nozawa, Vera Regina de Moraes Coimbra, Rafael de Moraes Ianotti, Clarice Shiguemi Hashizume, Roberto Kalil Filho, Jose Otavio Costa Auler, Fabio Biscegli Jatene, Filomena Regina Barbosa Gomes Galas, Marcelo Britto Passos Amato
Importance: Perioperative lung-protective ventilation has been recommended to reduce pulmonary complications after cardiac surgery. The protective role of a small tidal volume (VT) has been established, whereas the added protection afforded by alveolar recruiting strategies remains controversial. Objective: To determine whether an intensive alveolar recruitment strategy could reduce postoperative pulmonary complications, when added to a protective ventilation with small VT...
April 11, 2017: JAMA: the Journal of the American Medical Association
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