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PROTECT TRIAL 2011

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https://www.readbyqxmd.com/read/28086819/efficacy-safety-and-effectiveness-of-licensed-rotavirus-vaccines-a-systematic-review-and-meta-analysis-for-latin-america-and-the-caribbean
#1
Raúl F Velázquez, Alexandre C Linhares, Sergio Muñoz, Pamela Seron, Pedro Lorca, Rodrigo DeAntonio, Eduardo Ortega-Barria
BACKGROUND: RotaTeq™ (RV5; Merck & Co. Inc., USA) and Rotarix™ (RV1, GlaxoSmithKline, Belgium) vaccines, developed to prevent rotavirus diarrhea in children under five years old, were both introduced into national immunization programs in 2006. As many countries in Latin America and the Caribbean have included either RV5 or RV1 in their routine childhood vaccination programs, we conducted a systematic review and meta-analysis to analyze efficacy, safety and effectiveness data from the region...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28062312/incidence-and-risk-factors-for-post-ercp-pancreatitis-in-chronic-pancreatitis
#2
Zhen-Hua Zhao, Liang-Hao Hu, Hong-Bo Ren, An-Jing Zhao, Yang-Yang Qian, Xiao-Tian Sun, Song Su, Shu-Guang Zhu, Jin Yu, Wen-Bin Zou, Xiao-Rong Guo, Lei Wang, Zhao-Shen Li, Zhuan Liao
BACKGROUND AND AIMS: Almost all studies on post-ERCP pancreatitis (PEP) have mainly involved patients with biliary diseases, rather than chronic pancreatitis; and the concept that chronic pancreatitis (CP) seems to be a protective factor associated with PEP has not been studied in detail. The aim of this study was to determine the incidence of PEP in patients with CP at different clinical stages and to identify the predictive and protective factors of PEP in a large cohort. METHODS: This is an observational cohort study...
January 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28006819/better-resource-utilisation-and-quality-of-care-for-ovarian-cancer-patients-using-internet-based-pathology-review
#3
S Kommoss, F Kommoss, J Diebold, S Lax, D Schmidt, A Staebler, A du Bois, J Pfisterer
BACKGROUND: The current literature indicates that a considerable number of patients in ovarian carcinoma clinical trials have histopathological diagnoses in conflict with inclusion criteria. It has been suggested that specialised pathology review prior to randomisation should become the standard procedure in study protocols. We hypothesised that our new, internet-based high-throughput infrastructure would be capable of providing specialised pathology review within 10 working days (w.d...
December 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27996204/postoperative-pain-control-following-craniotomy-a-systematic-review-of-recent-clinical-literature
#4
Georgia G Tsaousi, Simon W Logan, Federico Bilotta
BACKGROUND: Pain intensity after craniotomy is considered to be moderate to severe during the first 2 postoperative days. The ideal pain treatment to facilitate a rapid postoperative recovery and optimize outcome is unknown. OBJECTIVES: This systematic review aims to report current clinical evidence related to pharmacological and adjuvant analgesic modalities for postcraniotomy pain control. DESIGN: Systematic review of randomized controlled trials (RCTs)...
December 20, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27905110/distinct-molecular-landscapes-between-endometrioid-and-non-endometrioid-uterine-carcinomas
#5
Nathaniel L Jones, Joanne Xiu, Sudeshna Chatterjee-Paer, Alexandre Buckley de Meritens, William M Burke, Ana I Tergas, Jason D Wright, June Y Hou
Endometrial carcinoma (EC) is traditionally characterized as endometrioid and non-endometrioid based on histo-pathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between March 2011 and July 2014: 1634 Type I and 1226 Type II. In situ hybridization and immunohistochemistry were used to assess copy number and protein expression of selected genes. Sequenced variants in 47 genes were analyzed using the Illumina TruSeq Amplicon Cancer Panel...
December 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27862573/association-between-change-in-employment-participation-and-quality-of-life-in-middle-aged-colorectal-cancer-survivors-compared-with-general-population-controls
#6
Vanessa L Beesley, Jeff K Vallance, Gabor Mihala, Brigid M Lynch, Louisa G Gordon
OBJECTIVE: This study aimed to examine the association between change in employment participation for a 12-month period and quality of life among individuals with colorectal cancer compared with general population controls. METHODS: This was a prospective, registry-based study that enrolled middle-aged (45-64 years) residents of Queensland, Australia, who were in the paid workforce, and newly diagnosed with colorectal cancer. Participants completed structured telephone interviews at 6 and 12 months after diagnosis assessing quality of life and employment status ("retired/ceased work," "increased work," "decreased work," and "maintained work")...
November 8, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27801991/short-to-midterm-effectiveness-of-a-brief-motivational-intervention-to-reduce-alcohol-use-and-related-problems-for-alcohol-intoxicated-children-and-adolescents-in-pediatric-emergency-departments-a-randomized-controlled-trial
#7
Nicolas Arnaud, Silke Diestelkamp, Lutz Wartberg, Peter-Michael Sack, Anne Daubmann, Rainer Thomasius
OBJECTIVES: The proportion of children and adolescents receiving emergency care for acute alcohol intoxication (AAI) in Germany has sharply increased over the past years. Despite this, no randomized controlled trials (RCTs) have studied guideline- and evidence-based interventions to prevent future alcohol misuse within this population. The objective of our investigation was to evaluate the effectiveness of a brief motivational intervention (b-MI) to reduce drinking and associated problems within pediatric emergency departments (PED) in Hamburg, Germany...
November 1, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27773708/the-impact-of-an-iud-and-implant-intervention-on-dual-method-use-among-young-women-results-from-a-cluster-randomized-trial
#8
Alison M El Ayadi, Corinne H Rocca, Julia E Kohn, Denisse Velazquez, Maya Blum, Sara J Newmann, Cynthia C Harper
Long-acting reversible contraceptives (LARCs) are highly effective at preventing pregnancy but do not protect against sexually transmitted infection (STI). Recent efforts to improve access to intrauterine devices (IUDs) and implants have raised concerns about STI prevention and reduced condom use, particularly among teenagers and young women. We evaluated whether a provider-targeted intervention to increase LARC access negatively impacted dual method use and STI incidence among an at-risk patient population...
January 2017: Preventive Medicine
https://www.readbyqxmd.com/read/27756265/motivational-counselling-and-sms-reminders-for-reduction-of-daily-sitting-time-in-patients-with-rheumatoid-arthritis-a-descriptive-randomised-controlled-feasibility-study
#9
T Thomsen, M Aadahl, N Beyer, M L Hetland, K Løppenthin, J Midtgaard, R Christensen, B A Esbensen
BACKGROUND: Patients with rheumatoid arthritis (RA) spend a high proportion of their waking time in sedentary behaviour (SB) and have an increased risk of cardiovascular disease. Reduction of SB and increase in light intensity physical activity has been suggested as a means of improvement of health in patients with mobility problems. Short-term intervention studies have demonstrated that SB can be reduced by behavioural interventions in sedentary populations. To evaluate descriptively the feasibility of recruitment, randomisation, outcome assessments, retention and the acceptability of an individually tailored, theory-based behavioural intervention targeting reduction in daily sitting time in patients with RA...
October 18, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27754000/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#10
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748307/impact-of-community-based-health-insurance-in-rural-india-on-self-medication-financial-protection-of-the-insured
#11
David M Dror, Arpita Chakraborty, Atanu Majumdar, Pradeep Panda, Ruth Koren
BACKGROUND & OBJECTIVES: The evidence-base of the impact of community-based health insurance (CBHI) on access to healthcare and financial protection in India is weak. We investigated the impact of CBHI in rural Uttar Pradesh and Bihar s0 tates of India on insured households' self-medication and financial position. METHODS: Data originated from (i) household surveys, and (ii) the Management Information System of each CBHI. Study design was "staggered implementation" cluster randomized controlled trial with enrollment of one-third of the treatment group in each of the years 2011, 2012 and 2013...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27745812/meningococcal-serogroup-b-specific-responses-after-vaccination-with-bivalent-rlp2086-4-year-follow-up-of-a-randomised-single-blind-placebo-controlled-phase-2-trial
#12
Helen S Marshall, Peter C Richmond, Johannes Beeslaar, Qin Jiang, Kathrin U Jansen, Maria Garcés-Sánchez, Federico Martinón-Torres, Leszek Szenborn, Jacek Wysocki, Joseph Eiden, Shannon L Harris, Thomas R Jones, Su-San Lee, John L Perez
BACKGROUND: Bivalent rLP2086 is a recombinant factor H binding protein-based vaccine approved in the USA for prevention of meningococcal serogroup B disease in 10-25-year-olds. We aimed to assess the persistence of bactericidal antibodies up to 4 years after a three-dose schedule of bivalent rLP2086. METHODS: We did this randomised, single-blind, placebo-controlled, phase 2 trial at 25 sites in Australia, Poland, and Spain. In stage 1 of the study (February, 2009-May, 2010), healthy adolescents (aged 11-18 years) were randomly assigned, via an interactive voice and web-response system with computer-generated sequential random numbers, to receive either ascending doses of vaccine (60 μg, 120 μg, and 200 μg) or placebo at months 0, 2, and 6...
January 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27714941/bevacizumab-for-non-small-cell-lung-cancer-a-nested-case-control-study-of-risk-factors-for-hemoptysis
#13
Koichi Goto, Masahiro Endo, Masahiko Kusumoto, Nobuyuki Yamamoto, Yuichiro Ohe, Ayaka Shimizu, Masahiro Fukuoka
Potentially life-threatening, serious hemoptysis is an adverse event associated with bevacizumab in non-squamous non-small-cell lung cancer (NSCLC) trials. Suggested risk factors include central tumor location and cavitation; however, the profile of hemoptysis occurrence in clinical practice is still unclear. A nested case-control study was conducted to assess the onset profile and risk factors for hemoptysis in bevacizumab-treated patients in a real-world setting in Japan. After bevacizumab was approved for NSCLC, physicians registered all NSCLC patients scheduled for bevacizumab therapy, from November 2009 to August 2011...
December 2016: Cancer Science
https://www.readbyqxmd.com/read/27711920/association-of-adjuvant-tamoxifen-and-aromatase-inhibitor-therapy-with-contralateral-breast-cancer-risk-among-us-women-with-breast-cancer-in-a-general-community-setting
#14
Gretchen L Gierach, Rochelle E Curtis, Ruth M Pfeiffer, Maeve Mullooly, Estelle A Ntowe, Robert N Hoover, Sarah J Nyante, Heather Spencer Feigelson, Andrew G Glass, Amy Berrington de Gonzalez
Importance: Within 10 years after breast cancer diagnosis, roughly 5% of patients develop contralateral breast cancer (CBC). Randomized trials have found that therapy including tamoxifen citrate and aromatase inhibitors (AIs) reduces CBC risk. But little is known about the magnitude and duration of protective associations within the context of real-world clinical management settings, where varying durations of and gaps in treatment are common. Objective: To determine the association between adjuvant tamoxifen and AI therapy and CBC risk within a general community setting...
October 6, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27500266/results-of-the-top-study-prospectively-randomized-multicenter-trial-of-an-ex-vivo-tacrolimus-rinse-before-transplantation-in-edc-livers
#15
Sebastian Pratschke, Hannah Arnold, Alfred Zollner, Michael Heise, Andreas Pascher, Peter Schemmer, Marcus N Scherer, Andreas Bauer, Karl-Walter Jauch, Jens Werner, Markus Guba, Martin K Angele
BACKGROUND: Organ shortage results in the transplantation of extended donor criteria (EDC) livers which is associated with increased ischemia-reperfusion injury (IRI). Experimental studies indicate that an organ rinse with the calcineurin inhibitor tacrolimus before implantation protects against IRI. The tacrolimus organ perfusion study was initiated to examine the effects of ex vivo tacrolimus perfusion on IRI in transplantation of EDC livers. METHODS: A prospective randomized multicenter trial comparing ex vivo perfusion of marginal liver grafts (≥2 EDC according to Eurotransplant manual) with tacrolimus (20 ng/mL) or histidine-tryptophane-ketoglutarate solution (control) was carried out at 5 German liver transplant centers (Munich Ludwig-Maximilians University, Berlin, Heidelberg, Mainz, Regensburg) between October 2011 and July 2013...
June 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27401569/intermittent-preventive-treatment-with-dihydroartemisinin-piperaquine-in-ugandan-schoolchildren-selects-for-plasmodium-falciparum-transporter-polymorphisms-that-modify-drug-sensitivity
#16
Joaniter I Nankabirwa, Melissa D Conrad, Jennifer Legac, Stephen Tukwasibwe, Patrick Tumwebaze, Bonnie Wandera, Simon J Brooker, Sarah G Staedke, Moses R Kamya, Sam L Nsobya, Grant Dorsey, Philip J Rosenthal
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012, monthly DP for 1 year decreased the incidence of malaria by 96% compared to placebo; DP once per school term offered protection primarily during the first month after therapy. To assess the impact of DP on selection of drug resistance, we compared the prevalence of key polymorphisms in isolates that emerged at different intervals after treatment with DP...
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27380464/duration-of-infant-protection-against-influenza-illness-conferred-by-maternal-immunization-secondary-analysis-of-a-randomized-clinical-trial
#17
Marta C Nunes, Clare L Cutland, Stephanie Jones, Andrea Hugo, Richard Madimabe, Eric A F Simões, Adriana Weinberg, Shabir A Madhi
IMPORTANCE: Influenza immunization of women during pregnancy protects the young infants against influenza illness. The duration of this protection remains unclear. OBJECTIVE: To evaluate the duration of infant protection conferred by maternal immunization and its association with transplacental antibody transfer. DESIGN, SETTING, AND PARTICIPANTS: Infants born to women who participated in a randomized, double-blind, placebo-controlled clinical trial in 2011 and 2012 on the safety, immunogenicity, and efficacy of trivalent inactivated influenza vaccine (IIV3) during pregnancy were followed up during the first 6 months of life for polymerase chain reaction (PCR)-confirmed influenza illness...
September 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27222473/a-phase-2-multicenter-study-investigating-ofatumumab-and-bendamustine-combination-in-patients-with-untreated-or-relapsed-cll
#18
Ian W Flinn, Panayiotis Panayiotidis, Boris Afanasyev, Ann Janssens, Sebastian Grosicki, Wojciech Homenda, Lukas Smolej, Kazimierz Kuliczkowski, Michael Doubek, Natalia Domnikova, Sarah L West, Chai-Ni Chang, Alison M Barker, Ira V Gupta, Oliver J Wright, Fritz Offner
The purpose of this study is to assess the safety and efficacy of the combination of ofatumumab and bendamustine in patients with previously untreated or relapsed chronic lymphocytic leukemia. Patients received IV ofatumumab (cycle 1: 300 mg day 1 and 1,000 mg day 8; cycles 2-6: 1,000 mg on day 1 every 28 days) and IV bendamustine 90 mg m(-2) (previously untreated) or 70 mg m(-2) (relapsed) on days 1 and 2 of each 28-day cycle, for up to 6 cycles. Forty-four previously untreated and 53 relapsed patients were enrolled...
September 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27222059/symptom-trajectory-and-symptom-burden-in-older-people-with-multimorbidity-secondary-outcome-from-the-rct-age-fit-study
#19
Jeanette Eckerblad, Kersti Theander, Anne W Ekdahl, Tiny Jaarsma
AIM: The aim of this study was to follow the symptom trajectory of community-dwelling older people with multimorbidity and to explore the effect on symptom burden from an ambulatory geriatric care unit, based on comprehensive geriatric assessment. BACKGROUND: Older community-dwelling people with multimorbidity suffer from a high symptom burden with a wide range of co-occurring symptoms often resulting to decreased health-related quality of life. There is a need to move from a single-disease model and address the complexity of older people living with multimorbidity...
November 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27212228/influenza-vaccination-of-pregnant-women-protects-them-over-two-consecutive-influenza-seasons-in-a-randomized-controlled-trial
#20
Eleonora Mutsaerts, Shabir A Madhi, Clare L Cutland, Stephanie Jones, Andrea Hugo, Siobhan Trenor, Florette K Treurnicht, Kerstin Klipstein-Grobusch, Adriana Weinberg, Marta C Nunes
BACKGROUND: We assessed the persistence of hemagglutinin inhibition (HAI) antibodies and the vaccine efficacy (VE) of trivalent inactivated influenza vaccine (IIV3) following vaccination of a cohort of pregnant South African women during a second influenza season. METHODS: A cohort of women who participated in a randomized placebo-controlled trial on the safety, immunogenicity and efficacy of IIV3 in 2011 had HAI titers measured in 2012 and were monitored for influenza illness until the end of 2012...
August 2016: Expert Review of Vaccines
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