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https://www.readbyqxmd.com/read/29453629/-the-application-of-different-injection-methods-for-cervical-and-lumbar-syndromes
#1
F Faber, A Benditz, D Boluki, J Grifka
The differentiated consideration of cervical and lumbar pain syndromes leads to a decoding of complaints to assignable pain generators which enables a targeted injection method. Depending on the origin of pain injections are placed at the nerve root or the joints. Thus, the vicious cycle can be stopped. A correct technical procedure is of enormous importance. Because pharmacological effects and special complications are possible, monitoring and precautions are mandatory.
February 16, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29451889/effects-of-patterned-peripheral-nerve-stimulation-on-soleus-spinal-motor-neuron-excitability
#2
Samuel Jimenez, Laura Mordillo-Mateos, Michele Dileone, Michela Campolo, Carmen Carrasco-Lopez, Fabricia Moitinho-Ferreira, Tomas Gallego-Izquierdo, Hartwig R Siebner, Josep Valls-Solé, Juan Aguilar, Antonio Oliviero
Spinal plasticity is thought to contribute to sensorimotor recovery of limb function in several neurological disorders and can be experimentally induced in animals and humans using different stimulation protocols. In healthy individuals, electrical continuous Theta Burst Stimulation (TBS) of the median nerve has been shown to change spinal motoneuron excitability in the cervical spinal cord as indexed by a change in mean H-reflex amplitude in the flexor carpi radialis muscle. It is unknown whether continuous TBS of a peripheral nerve can also shift motoneuron excitability in the lower limb...
2018: PloS One
https://www.readbyqxmd.com/read/29451448/donor-nerve-axotomy-and-axonal-regeneration-after-end-to-side-neurorrhaphy-in-a-rodent-model
#3
Shiwei Wang, Diya Su, Jing Li, Dezhi Li, Hong Wan, Michael Schumacher, Song Liu
OBJECTIVE In this study, the authors used a surgical model of end-to-side neurorrhaphy between a nerve graft and a donor tibial nerve in adult rats to investigate the optimal conditions for axonal regeneration induced by the donor nerve. They also assessed the importance of a more favorable pathway using a predegenerated nerve graft to attract regenerating axons to regrow into the graft and then directing and improving their growth toward the target in comparison with results obtained with a fresh nerve graft...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29449772/differential-examination-diagnosis-and-management-for-tingling-in-toes-fellow-s-case-problem
#4
Cody J Mansfield, Jake Bleacher, Paul Tadak, Matthew S Briggs
Background: The diagnosis of chronic exertional compartment syndrome can be challenging as other pathologies involving bone, muscle, nerve and vascular structures can mimic the syndrome. The purpose of this Fellow's Case Problem is to describe the clinical decision-making and physical therapy differential diagnosis regarding a 25-year-old patient with un-resolved neurovascular complaints following chronic exertional compartment syndrome surgical release. Diagnosis: After surgery, the patient's previous complaint of numbness and tingling in the plantar surfaces of her first and second toes of right foot was still present...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29447305/pseudo-pedicle-heterotopic-ossification-from-use-of-recombinant-human-bone-morphogenetic-protein-2-rhbmp-2-in-transforaminal-lumbar-interbody-fusion-cages
#5
Charles D Rosen, P Douglas Kiester, Thay Q Lee
We conducted a study to determine the common characteristics of patients who developed radiculopathy symptoms and corresponding heterotopic ossification (HO) from transforaminal lumbar interbody fusions (TLIF) using recombinant human bone morphogenetic protein 2 (rhBMP-2). HO can arise from a disk space with rhBMP-2 use in TLIF. Formation of bone around nerve roots or the thecal sac can cause a radiculopathy with a consistent pattern of symptoms. We identified 38 patients (26 males, 12 females) with a mean (SD) age of 50...
January 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29447134/histone-deacetylase-5-hdac5-regulates-neuropathic-pain-through-sry-related-hmg-box-10-sox10-dependent-mechanism-in-mice
#6
Pan Gu, Zhiqiang Pan, Xiao-Min Wang, Liting Sun, Lydia Wai Tai, Chi Wai Cheung
A strong link between histone deacetylases (HDACs) and nociceptive hypersensitivity has been indicated in different pain models. However, the underlying molecular and cellular mechanisms remain elusive. Here, we discovered that partial sciatic nerve ligation-induced mechanical allodynia and thermal hyperalgesia in mice were associated with increased mRNA and protein expressions of HDAC5 (a member of class IIa HDACs) and SRY-related HMG-box 10 (SOX10) in the ipsilateral lumbar dorsal horn. Gene knockdown of spinal HDAC5 or SOX10 attenuated partial sciatic nerve ligation-induced nociceptive hypersensitivity, companied with decrease of spinal neuronal sensitization markers, namely phosphorylated-Erk, phosphorylated-GluN1 (ser896), and c-Fos...
March 2018: Pain
https://www.readbyqxmd.com/read/29445951/full-endoscopic-lumbar-interbody-fusion-felif-technical-note
#7
Myung Soo Youn, Jong Ki Shin, Tae Sik Goh, Jung Sub Lee
PURPOSE: Interbody fusion by open discectomy is the usual treatment for degenerative lumbar disease but requires a relatively long recovery period. Prevalent several interbody fusion methods have shown limitations by its own character. Full endoscopic lumbar interbody fusion (FELIF) has advantages in direct decompression of pathology with minimal invasive technique. We report novel technique of endoscopic fusion method through full guided with endoscopic view monitoring system. METHODS: The authors provide an introduction of FELIF technique followed by a description of the technical steps with discussion on its indications and advantages...
February 14, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29438491/new-insights-on-a-ngf-mediated-pathway-to-induce-ovulation-in-rabbits-oryctolagus-cuniculus
#8
Margherita Maranesi, Linda Petrucci, Leonardo Leonardi, Federica Piro, Pilar García Rebollar, Pilar Millán, Paolo Cocci, Cecilia Vullo, Francesco Parillo, Arlindo Moura, Gabriela Gonzalez Mariscal, Cristiano Boiti, Massimo Zerani
To investigate the ovulatory mechanisms triggered by raw semen in rabbits, we examined the expression of nerve growth factor (NGF)-a supposed ovulation-inducing factor (OIF)-and cognate receptors in anterior pituitary, ovary, and cervix as well as plasma NGF and LH concentrations. Six does/group were: sham-inseminated with sterile saline (PBS), naturally mated (NM), inseminated with raw semen alone (RS) or after lumbar anesthesia (ARS) or treatment with COX inhibitors (CIRS). Immunohistochemistry revealed positive signals for NGF and receptors in all tissues...
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29424413/-acute-polyradiculoneuropathy-associated-with-human-herpes-virus-7-in-an-immunocompetent-patient-case-report
#9
Paula Jara, José Manuel Matamala, Renato Verdugo, Luis Thompson
Human herpes virus 7 (HHV-7) is a cause of encephalitis, meningitis and myeloradiculoneuropathy in adults who are immunocompetent or with immunosuppression. The involvement of the peripheral nervous system is always associated with myelitis. We report a case of acute polyradiculoneuropathy due to HHV-7, without involvement of central nervous system, in an immunocompetent patient. A 35-years-old man complained of lumbar pain radiating to both buttocks. On examination muscle strength and tendon reflexes were normal...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29424098/diagnosis-of-compressed-nerve-root-in-lumbar-disc-herniation-patients-by-surface-electromyography
#10
Wei Li, Yan-Cheng Liu, Chen-Fan Zheng, Jun Miao, Hui Chen, Hai-Ying Quan, Song-Hua Yan, Kuan Zhang
OBJECTIVE: To establish a logistic regression model using surface electromyography (SEMG) parameters for diagnosing the compressed nerve root at L 5 or S 1 level in patients with lumbar disc herniation (LDH). METHODS: This study recruited 24 patients with L 5 nerve root compression and 23 patients with S 1 nerve root compression caused by LDH from May 2014 to May 2016. SEMG signals from the bilateral tibialis anterior and lateral gastrocnemius were measured. The root mean square (RMS), the RMS peak time, the mean power frequency (MPF), and the median frequency (MF) were analyzed...
February 9, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29424083/multicenter-reproducibility-study-of-diffusion-mri-and-fiber-tractography-of-the-lumbosacral-nerves
#11
Wieke Haakma, Jeroen Hendrikse, Lars Uhrenholt, Alexander Leemans, Lene Warner Thorup Boel, Michael Pedersen, Martijn Froeling
BACKGROUND: Diffusion tensor imaging (DTI) has been applied in the lumbar and sacral nerves in vivo, but information about the reproducibility of this method is needed before DTI can be used reliably in clinical practice across centers. PURPOSE: In this multicenter study the reproducibility of DTI of the lumbosacral nerves in healthy volunteers was investigated. STUDY TYPE: Prospective control series. SUBJECTS: Twenty healthy subjects...
February 9, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29423951/early-calp2-expression-and-microglial-activation-are-potential-inducers-of-spinal-il-6-upregulation-and-bilateral-pain-following-motor-nerve-injury
#12
Shao-Xia Chen, Shao-Kun Wang, Pei-Wen Yao, Guang-Jie Liao, Xiao-Dong Na, Yong-Yong Li, Wei-An Zeng, Xian-Guo Liu, Ying Zang
Previous work from our laboratory showed that motor nerve injury by lumbar 5 ventral root transection (L5-VRT) led to interleukin-6 (IL-6) overexpression in bilateral spinal cord, and that intrathecal administration of IL-6 neutralizing antibody delayed the induction of mechanical allodynia in bilateral hind paws. However, early events and upstream mechanisms underlying spinal IL-6 expression following L5-VRT require elucidation. The model of L5-VRT was used to induce neuropathic pain, which was assessed with von Frey hairs and the plantar tester in adult male Sprague-Dawley rats...
February 9, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29420729/combination-treatment-with-exogenous-gdnf-and-fetal-spinal-cord-cells-results-in-better-motoneuron-survival-and-functional-recovery-after-avulsion-injury-with-delayed-root-reimplantation
#13
Carolin Ruven, Smaranda-Ruxandra Badea, Wai-Man Wong, Wutian Wu
When spinal roots are torn off from the spinal cord, both the peripheral and central nervous system get damaged. As the motoneurons lose their axons, they start to die rapidly, whereas target muscles atrophy due to the denervation. In this kind of complicated injury, different processes need to be targeted in the search for the best treatment strategy. In this study, we tested glial cell-derived neurotrophic factor (GDNF) treatment and fetal lumbar cell transplantation for their effectiveness to prevent motoneuron death and muscle atrophy after the spinal root avulsion and delayed reimplantation...
February 6, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29419657/neuroinflammation-of-the-spinal-cord-and-nerve-roots-in-chronic-radicular-pain-patients
#14
Daniel Albrecht, Shihab Ahmed, Norman Kettner, Ronald Borra, Julien Cohen-Adad, Hao Deng, Timothy Houle, Arissa Opalacz, Sarah Roth, Marcos Vidal Melo, Lucy Chen, Jianren Mao, Jacob Hooker, Marco L Loggia, Yi Zhang
Numerous preclinical studies support the role of spinal neuroimmune activation in the pathogenesis of chronic pain, and targeting glia (e.g., microglia/astrocyte)- or macrophage-mediated neuroinflammatory responses effectively prevents or reverses the establishment of persistent nocifensive behaviors in laboratory animals. However, thus far the translation of those findings into novel treatments for clinical use has been hindered by the scarcity of data supporting the role of neuroinflammation in human pain...
February 5, 2018: Pain
https://www.readbyqxmd.com/read/29417772/-case-control-study-on-two-different-surgical-approaches-combined-fixation-with-lumbar-interbody-fusion-for-the-treatment-of-single-segmental-lumbar-vertebra-diseases
#15
Zhong-You Zeng, Wei-Feng Yan, Yong-Xing Song, Ke-Ya Mao, Jian-Fei Ji, Jian-Qiao Zhang, Peng Wu, Fei Pei, Guo-Hao Song, Jian-Fu Han, Wei Yu
OBJECTIVE: To discuss the advantages and disadvantages of two different surgical approaches combined fixation with lumbar interbody fusion in treating single segmental lumbar vertebra diseases. METHODS: The clinical data of 86 patients with single segmental lumbar vertebra diseases treated from June 2011 to June 2013 was retrospectively analyzed. There were 33 males and 53 females, aged from 28 to 76 years old with an average of 53.0 years. Among them, there were 39 cases of lumbar disc degeneration, 22 cases of lumbar disc herniation complicated with spinal canal stenosis, 9 cases of huge lumbar disc herniation and 16 cases of lumbar degenerative spondylolisthesis (Meyerding degree I )...
May 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29415941/-neurolymphomatosis-due-to-enteropathy-associated-t-cell-lymphoma-clinically-diagnosed-by-fdg-pet-ct-and-subsequently-confirmed-by-autopsy
#16
Nozomu Uematsu, Masahiko Sumi, Hiroko Kaiume, Wataru Takeda, Takehiko Kirihara, Toshimitsu Ueki, Yuki Hiroshima, Mayumi Ueno, Naoaki Ichikawa, Masahide Watanabe, Hikaru Kobayashi
A 59-year-old man who complained of abdominal pain was referred to our hospital. Computed tomography (CT) revealed mesenteric lymph node swelling and intestinal perforation. Histopathological study of the resected ileum and lymph node demonstrated diffuse proliferation of medium-sized atypical lymphocytes. Immunohistochemistry results were positive for cluster of differentiation (CD) 3, CD8, and CD56 cells, negative for CD5 and CD4 cells, and negative for Epstein-Barr virus-encoded RNA-fluorescent in situ hybridization (EBER-FISH)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29415656/comparison-of-lumbar-plexus-block-using-the-short%C3%A2-axis-in-plane-method-at-the-plane-of-the-transverse-process-and-at-the-articular-process-a-randomized-controlled-trial
#17
Rui Lu, Chengcheng Shen, Chunyong Yang, Yan Chen, Juanjuan Li, Kaizhi Lu
BACKGROUND: Although the safety and effectiveness of the short-axis in-plane method has been confirmed for lumbar plexus block, the operation is difficult and has a high rate of epidural spread at the plane of the articular process. Therefore, we developed a new in-plane technique, called the beach chair method, which displays images from the transverse process. We compared the operative difficulty and incidence of epidural spread of the beach chair method with those of the control method (at the plane of the articular process) in this randomized controlled clinical trial...
February 7, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29410172/impact-of-additional-treatment-of-para-lumbar-and-peripheral-nerve-diseases-after-lumbar-spine-surgery
#18
Juntaro Matsumoto, Toyohiko Isu, Kyongsong Kim, Naotaka Iwamoto, Kazuyoshi Yamazaki, Daijiro Morimoto, Masanori Isobe
INTRODUCTION: Some patients suffer failed back surgery syndrome (FBSS) after lumbar spine surgery. We report the effect of additional treatments for para-lumbar- and peripheral nerve diseases addressing residual symptoms after lumbar spine surgery. MATERIALS AND METHODS: We enrolled 74 patients (59 men and 15 women, mean age 62.9 years) who had undergone lumbar posterior decompression surgery in our department. Mean follow-up after initial lumbar surgery was 26...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29408929/cytokine-mediated-inflammation-mediates-painful-neuropathy-from-metabolic-syndrome
#19
Can Zhang, Joseph Ward, Jacqueline R Dauch, Rudolph E Tanzi, Hsinlin T Cheng
Painful neuropathy (PN) is a prevalent condition in patients with metabolic syndrome (MetS). However, the pathogenic mechanisms of metabolic syndrome-associated painful neuropathy (MetSPN) remain unclear. In the current study, high-fat-fed mice (HF mice) were used to study MetSPN. HF mice developed MetS phenotypes, including increased body weight, elevated plasma cholesterol levels, and insulin resistance in comparison with control-fat-fed (CF) mice. Subsequently, HF mice developed mechanical allodynia and thermal hyperalgesia in hind paws after 8 wk of diet treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29408676/distortion-free-diffusion-tensor-imaging-for-evaluation-of-lumbar-nerve-roots-utility-of-direct-coronal-single-shot-turbo-spin-echo-diffusion-sequence
#20
Takayuki Sakai, Kunio Doi, Masami Yoneyama, Atsuya Watanabe, Tosiaki Miyati, Noriyuki Yanagawa
PURPOSE: Diffusion tensor imaging (DTI) based on a single-shot echo planer imaging (EPI-DTI) is an established method that has been used for evaluation of lumbar nerve disorders in previous studies, but EPI-DTI has problems such as a long acquisition time, due to a lot of axial slices, and geometric distortion. To solve these problems, we attempted to apply DTI based on a single-shot turbo spin echo (TSE-DTI) with direct coronal acquisition. Our purpose in this study was to investigate whether TSE-DTI may be more useful for evaluation of lumbar nerve disorders than EPI-DTI...
January 30, 2018: Magnetic Resonance Imaging
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