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https://www.readbyqxmd.com/read/29922746/reduced-intraepidermal-nerve-fibre-density-glial-activation-and-sensory-changes-in-hiv-type-1-tat-expressing-female-mice-involvement-of-tat-during-early-stages-of-hiv-associated-painful-sensory-neuropathy
#1
Rachel Wodarski, Deniz Bagdas, Jason J Paris, Tim Pheby, Wisam Toma, Ruqiang Xu, M Imad Damaj, Pamela E Knapp, Andrew S C Rice, Kurt F Hauser
Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice conditionally expressing HIV Tat1-86 protein through a doxycycline (DOX)-driven glial fibrillary acidic protein promoter, intraepidermal nerve fibre density and immune cell activation in the dorsal root ganglion (DRG) and spinal cord were assessed by immunohistochemistry...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29920389/long-term-minimum-clinically-important-difference-mcid-in-health-related-quality-of-life-scores-after-instrumented-lumbar-interbody-fusion-for-low-grade-isthmic-spondylolisthesis
#2
Ju-Wan Seuk, Junseok Bae, Sang-Ho Lee, Sang-Ha Shin, Ho Jin Kim
BACKGROUND: Even with its growing popularity, there weren't any comparative studies that explored MCID of HRQoLs following LIF performed on a single-level adult LGIS. OBJECTIVE: The purpose of this study is to investigate factors related to MCID of HRQoLs following instrumented LIF performed on a single-level adult LGIS. METHODS: Consecutive patients who underwent instrumented LIF for single-level LGIS were reviewed. The inclusion criteria were : adult patients who underwent L4-5 or L5-S1, ALIF or TLIF with a posterior screw fixation, and had a minimum 36-month post-operative follow-up period...
June 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29920290/cell-and-stage-specific-localization-of-galectin-3-a-%C3%AE-galactoside-binding-lectin-in-a-mouse-model-of-experimental-autoimmune-encephalomyelitis
#3
Tetsuya Itabashi, Yasunobu Arima, Daisuke Kamimura, Kotaro Higuchi, Yoshio Bando, Hiromi Takahashi-Iwanaga, Masaaki Murakami, Masahiko Watanabe, Toshihiko Iwanaga, Junko Nio-Kobayashi
Multiple sclerosis (MS) is an autoimmune disease in which pathogenic T cells play an important role, and an experimental autoimmune encephalomyelitis (EAE) is used as an animal model of MS. Galectins are β-galactoside-binding lectins and involved in various physiological and pathological events. Among fifteen members of galectins, galectin-1, -8, and -9 play immunosuppressive roles in MS and EAE; however, the role of galectin-3 (gal-3) is complex and controversial. We examined expression of gal-3 in the spinal cord and nerve roots of EAE mice...
June 16, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29913995/diagnostic-blocks-for-chronic-pain
#4
Michele Curatolo, Nikolai Bogduk
Many conditions associated with chronic pain have no detectable morphological correlate. Consequently, the source of pain cannot be established by clinical examination or medical imaging. However, for some such conditions, the source of pain can be established using diagnostic blocks. The aim of this paper is to review the available evidence concerning the validity and utility of diagnostic blocks, and to identify areas where research is needed. Diagnostic blocks for cervical and lumbar zygapophysial joint pain have been extensively studied...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913621/the-dqb1-03-02-hla-haplotype-is-associated-with-increased-risk-of-chronic-pain-after-inguinal-hernia-surgery-and-lumbar-disc-herniation
#5
C A Dominguez, M Kalliomäki, U Gunnarsson, A Moen, G Sandblom, I Kockum, E Lavant, T Olsson, F Nyberg, L J Rygh, C Røe, J Gjerstad, T Gordh, F Piehl
Neuropathic pain conditions are common after nerve injuries and are suggested to be regulated in part by genetic factors. We have previously demonstrated a strong genetic influence of the rat major histocompatibility complex on development of neuropathic pain behavior after peripheral nerve injury. In order to study if the corresponding human leukocyte antigen complex (HLA) also influences susceptibility to pain, we performed an association study in patients that had undergone surgery for inguinal hernia (n = 189)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912007/plasticity-and-function-of-spinal-oxytocin-and-vasopressin-signaling-during-recovery-from-surgery-with-nerve-injury
#6
Amie L Severino, Rong Chen, Kenichiro Hayashida, Carol A Aschenbrenner, Haiguo Sun, Christopher M Peters, Silvia Gutierrez, Bethany Pan, James C Eisenach
BACKGROUND: Recovery from pain after surgery is faster after cesarean delivery than after other abdominal procedures. The authors hypothesized that recovery in rats after surgery could be reversed by antagonism of spinal oxytocin or vasopressin receptors, that there may be a sex difference, and that spinal oxytocin innervation could change after surgery. METHODS: Male and female rats underwent partial spinal nerve ligation surgery. Effects of nonselective and selective oxytocin and vasopressin 1A receptor antagonists on mechanical hypersensitivity during partial recovery were assessed (n = 8 to 14/group)...
June 15, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29911649/systemic-administration-of-wy-14643-a-selective-synthetic-agonist-of-peroxisome-proliferator-activator-receptor-alpha-alters-spinal-neuronal-firing-in-a-rodent-model-of-neuropathic-pain
#7
Bright N Okine, Clare Spicer, Paul Millns, Andrew Bennett, Victoria Chapman
Background and aims The clinical management of chronic neuropathic pain remains a global health challenge. Current treatments are either ineffective, or associated with unwanted side-effects. The development of effective, safe therapies requires the identification of novel therapeutic targets using clinically relevant animal models of neuropathic pain. Peroxisome proliferator activated receptor alpha (PPARα), is a member of the nuclear hormone family of transcription factors, which is widely distributed in the peripheral and central nervous systems...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911625/local-up-regulation-of-interferon-%C3%AE-ifn-%C3%AE-following-disc-herniation-is-involved-in-the-inflammatory-response-underlying-acute-lumbar-radicular-pain
#8
G H Moen, A Moen, J Gjerstad
Aims Lumbar radicular pain after disc herniation may be associated release of pro-inflammatory cytokines from nucleus pulposus (NP) tissue. In the present study we examined the role of interferon-γ (IFN-γ) and cluster of differentiation 68 (CD68) in the acute phase of this process. Methods First, in an animal model mimicking the clinical situation after disc herniation, the role of IFN-γ on the dorsal horn single cell activity and gene expression close to the nerve roots was studied. Second, in patients with severe lumbar radicular pain due to disc herniation, we examined how two single nucleotide polymorphisms (SNPs; rs2069705 and rs2069718) important for the IFN-γ expression influenced the pain and disability measured by visual analogue scale (VAS) and Oswestry Disability Index (ODI)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911608/increased-c-fiber-response-induced-by-experimental-disc-herniation-is-associated-with-upregulation-of-fractalkine-and-its-receptor-in-nucleus-pulposus-and-dorsal-root-ganglion
#9
D P Jacobsen, A Moen, F Haugen, J Gjerstad
Aims Lumbar radicular pain following intervertebral disc herniation may be caused by a local inflammatory response induced by nucleus pulposus (NP) cells. Here in an animal model mimicking the clinical situation following disc herniation we investigated the effect of NP on the spinal nociceptive signaling and local gene expression. Methods In anaesthetized Lewis rats, extracellular single unit recordings of spinal nociceptive activity and qPCR were used to explore the effect of NP application onto the dorsal nerve roots (L3-L5)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909125/effectiveness-of-using-low-rate-fluoroscopy-to-reduce-an-examiner-s-radiation-dose-during-lumbar-nerve-root-block
#10
Kentaro Yamane, Nobuo Kai, Tetsuro Mazaki, Tadashi Miyamoto, Tomohiro Matsushita
BACKGROUND: Long-term exposure to radiation can lead to gene mutations and increase the risk of cancer. Low rate fluoroscopy has the potential to reduce the radiation exposure for both the examiner and the patient during various fluoroscopic procedures. The purpose of this study was to evaluate the impact of low rate fluoroscopy on reducing an examiner's radiation dose during nerve root block. METHODS: A total of 101 lumbar nerve root block examinations were performed at our institute during a 6-month period...
June 13, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29905043/-short-term-effectiveness-of-percutaneous-endoscopic-lumbar-discectomy-in-treatment-of-buttock-pain-associated-with-lumbar-disc-herniation
#11
Peng Cai, Qingquan Kong, Yueming Song
Objective: To evaluate the short-term effectiveness of percutaneous endoscopic lumbar discectomy (PELD) in treatment of buttock pain associated with lumbar disc herniation. Methods: Between June 2015 and May 2016, 36 patients with buttock pain associated with lumbar disc herniation were treated with PELD. Of 36 cases, 26 were male and 10 were female, aged from 18 to 76 years (mean, 35.6 years). The disease duration ranged from 3 months to 10 years (mean, 14 months)...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904039/an-unusual-cause-of-cauda-equina-syndrome-lumbar-epidural-venous-engorgement
#12
Husam A AlTahan, Roaa R Amer, Areej A Madani, Eman A Bakhsh
BACKGROUND Epidural venous plexus (EVP) engorgement occurs due to many conditions, so it can be easily misdiagnosed. This becomes problematic when the diagnosis requires prompt treatment for a good outcome, especially when it results in cauda equina syndrome (CES). We report a case of extensive iliocaval thrombosis leading to epidural venous plexus and ascending lumbar vein engorgement as an outcome of deep venous thrombosis (DVT) due to probable adverse effects of oral combined contraceptive pills (OCCP). CASE REPORT A 42-year-old woman presented to a rural medical facility with bilateral lower-limb swelling and skin darkening for 2 days...
June 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29886296/intradural-ganglioneuroma-mimicking-lumbar-disc-herniation-case-report
#13
Cristina Barrena López, Beatriz De la Calle García, Rosario Sarabia Herrero
Ganglioneuroma (GN) is a slow-growing tumor originating from the neural crest-derived cells, which form the sympathetic nervous system. These tumors can affect anywhere along the peripheral autonomic ganglion sites, being most commonly found in the mediastinum and retroperitoneum. Spinal GNs are extremely rare and, so far, only 1 case arising from a lumbar nerve root has been reported in English literature. GNs are often asymptomatic, and the majority of them, are found incidentally in healthy subjects. Due to its slow growth, symptoms may result from the compressive effect of the tumor...
June 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29879768/usefulness-of-oblique-lumbar-magnetic-resonance-imaging-for-nerve-root-anomalies-and-extraforaminal-entrapment-lesions
#14
Dong Hwa Heo, Seok Woo Kim, Hsien-Hao Chang, Choon-Keun Park
STUDY DESIGN: A retrospective review of prospectively evaluated magnetic resonance (MR) images. PURPOSE: Routine lumbar axial and sagittal MR images may not clearly demonstrate nerve root anomalies and entrapments in the extraforaminal region. Thus, lumbar extraforaminal lesions or nerve root anomalies may be underdiagnosed because of unfamiliar radiological anatomy. We aimed to investigate the clinical efficacy of our oblique magnetic resonance imaging (MRI) technique for diagnosing nerve root anomalies and entrapment lesions...
June 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29879473/homing-of-the-stem-cells-from-the-acupoint-st-36-to-the-site-of-a-spinal-cord-injury-a-preliminary-study
#15
Sharon Jiyoon Jung, Myung Geun Kook, Sungchul Kim, Kyung-Sun Kang, Kwang-Sup Soh
Homing of stem cells (SCs) to desired targets such as injured tissues remains a lingering problem in cell-based therapeutics. Studies on the biodistribution of intravenously administered SCs have shown the inefficacy of blood vessels as the homing path because most of the injected SCs are captured in the capillary beds of the lungs. We considered an alternative administration method utilizing the acupuncture meridians or the primo vascular system (PVS). We injected SCs at the acupoint Zusanli (ST-36) below the knee of a nude mouse with a spinal cord injured at the thoracic T9-10 vertebrae...
June 4, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29878716/complications-and-prevention-strategies-of-oblique-lateral-interbody-fusion-technique
#16
Zhong-You Zeng, Zhao-Wan Xu, Deng-Wei He, Xing Zhao, Wei-Hu Ma, Wen-Fei Ni, Yong-Xing Song, Jian-Qiao Zhang, Wei Yu, Xiang-Qian Fang, Zhi-Jie Zhou, Nan-Jian Xu, Wen-Jian Huang, Zhi-Chao Hu, Ai-Lian Wu, Jian-Fei Ji, Jian-Fu Han, Shun-Wu Fan, Feng-Dong Zhao, Hui Jin, Fei Pei, Shi-Yang Fan, De-Xiu Sui
OBJECTIVE: To analyze the early complications and causes of oblique lateral interbody fusion, and put forward preventive measures. METHODS: There were 235 patients (79 males and 156 females) analyzed in our study from October 2014 to May 2017. The average age was 61.9 ± 0.21 years (from 32 to 83 years). Ninety-one cases were treated with oblique lateral interbody fusion (OLIF) alone (OLIF alone group) and 144 with OLIF combined with posterior pedicle screw fixation through the intermuscular space approach (OLIF combined group)...
May 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29878345/headache-and-ophthalmoparesis-case-report-of-an-atypical-incomplete-miller-fisher-syndrome
#17
David Moreno-Ajona, Pablo Irimia, Marta Fernández-Matarrubia
OBJECTIVE: To expand the differential diagnosis of headache and ophthalmoparesis by describing a case report in which anti-GQ1b was demonstrated to be the cause. BACKGROUND: Anti-GQ1b antibody syndrome refers to a clinical spectrum of conditions that share common mechanisms and overlapping manifestations, including the Miller-Fisher syndrome, pharyngeal-cervical-brachial weakness, and Bickerstaff brainstem encephalitis. Rare atypical cases presenting as acute ophthalmoparesis (AO) without ataxia or areflexia have been described...
May 2018: Headache
https://www.readbyqxmd.com/read/29877872/comparison-of-decompression-decompression-plus-fusion-and-decompression-plus-stabilization-for-degenerative-spondylolisthesis-a-prospective-randomized-study
#18
Hiroyuki Inose, Tsuyoshi Kato, Masato Yuasa, Tsuyoshi Yamada, Hidetsugu Maehara, Takashi Hirai, Toshitaka Yoshii, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: This is a prospective, randomized controlled trial. OBJECTIVE: To prospectively assess the long-term clinical results of decompression alone, decompression plus fusion, and decompression plus stabilization for degenerative spondylolisthesis. SUMMARY OF BACKGROUND DATA: Symptoms of lumbar spinal stenosis due to degenerative spondylolisthesis originate from compression of the dural sac or nerve root. Essentially, this condition is treated by performing a decompression of neural structures...
June 5, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29871381/volume-navigation-with-fusion-of-real-time-ultrasound-and-ct-images-to-guide-posterolateral-transforaminal-puncture-in-percutaneous-endoscopic-lumbar-discectomy
#19
Yan-Bin Liu, Yin Wang, Zi-Qiang Chen, Jun Li, Wei Chen, Chuan-Feng Wang, Qiang Fu
BACKGROUND: The use of percutaneous endoscopic lumbar discectomy (PELD) is increasing in the treatment of lumbar disc herniations (LDH). Nerve and vessel injury may happen during the establishment of the transforaminal working channel. Also, there is usually exposure to intraop radiation when the C-arm is used to help establish the location of the transforaminal working channel. OBJECTIVE: To evaluate the accuracy and safety of the volume navigation technique for guiding transforaminal puncture in cadaver and clinical patient treatment...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29870848/controllable-risk-factors-for-neurological-complications-in-posterior-lumbar-interbody-fusion-as-revision-surgery
#20
Tomoya Yamashita, Shinya Okuda, Hiroyuki Aono, Tomiya Matsumoto, Takafumi Maeno, Tsuyoshi Sugiura, Motoki Iwasaki
OBJECTIVE: The main concern with revision lumbar surgery is the possibility of neurological complications. The purpose of this retrospective study was to clarify the risk factors, especially the effects of nerve stretching, for postoperative neurological complications in posterior lumbar interbody fusion (PLIF) without excessive nerve retraction by bilateral total facetectomy as revision surgery. METHODS: Between 2005 and 2015, 50 consecutive patients underwent revision PLIF for recurrent stenosis or recurrent disc herniation...
June 2, 2018: World Neurosurgery
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