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"Ferric pyrophosphate"

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https://www.readbyqxmd.com/read/27692637/a-review-of-ferric-pyrophosphate-citrate-triferic-use-in-hemodialysis-patients
#1
Tyler Albright, Akram Al-Makki, Rabih Kalakeche, Brian Shepler
PURPOSE: The objective of this short review is to evaluate the efficacy of ferric pyrophosphate citrate and to determine its place in therapy based on the current published literature. METHODS: A literature search was conducted and pared down to yield 4 placebo controlled Phase II and III clinically relevant trials. FINDINGS: Ferric pyrophosphate citrate is a new intradialytic iron supplementation product that has been found to reduce the dose of erythropoiesis-stimulating agents and intravenous iron supplementation and to increase serum ferritin concentrations...
September 27, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27557937/pharmacokinetics-of-ferric-pyrophosphate-citrate-a-novel-iron-salt-administered-intravenously-to-healthy-volunteers
#2
Raymond D Pratt, Dorine W Swinkels, T Alp Ikizler, Ajay Gupta
Ferric pyrophosphate citrate (Triferic) is a water-soluble iron salt that is administered via dialysate to maintain iron balance and hemoglobin in hemodialysis patients. This double-blind, randomized, placebo-controlled, single-, ascending-dose study was conducted to evaluate the pharmacokinetics and safety of intravenous ferric pyrophosphate citrate in 48 healthy iron-replete subjects (drug, n = 36; placebo, n = 12). Single doses of 2.5, 5.0, 7.5, or 10 mg of ferric pyrophosphate citrate or placebo were administered over 4 hours, and single doses of 15 or 20 mg of ferric pyrophosphate citrate or placebo were administered over 12 hours via intravenous infusion...
August 25, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27267429/sodium-pyrophosphate-enhances-iron-bioavailability-from-bouillon-cubes-fortified-with-ferric-pyrophosphate
#3
Colin I Cercamondi, Guus S M J E Duchateau, Rajwinder K Harika, Robin van den Berg, Peter Murray, Wieneke P Koppenol, Christophe Zeder, Michael B Zimmermann, Diego Moretti
Fe fortification of centrally manufactured and frequently consumed condiments such as bouillon cubes could help prevent Fe deficiency in developing countries. However, Fe compounds that do not cause sensory changes in the fortified product, such as ferric pyrophosphate (FePP), exhibit low absorption in humans. Tetra sodium pyrophosphate (NaPP) can form soluble complexes with Fe, which could increase Fe bioavailability. Therefore, the aim of this study was to investigate Fe bioavailability from bouillon cubes fortified with either FePP only, FePP+NaPP, ferrous sulphate (FeSO4) only, or FeSO4+NaPP...
August 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27236134/ferric-pyrophosphate-citrate-a-novel-iron-replacement-agent-in-patients-undergoing-hemodialysis
#4
REVIEW
Hitesh H Shah, Azzour D Hazzan, Steven Fishbane
Management of anemia remains an integral component in the care of patients with chronic kidney disease undergoing hemodialysis. In addition to erythropoiesis-stimulating agents, iron-replacement agents remain a key strategy for anemia treatment in this patient population. Ferric pyrophosphate citrate (FPC), a novel iron-replacement agent, was approved by the US Food and Drug Administration in January 2015 for use in adult patients receiving chronic hemodialysis (HD). This iron product is administered to patients on HD via the dialysate...
March 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27153768/we-give-too-much-intravenous-iron
#5
Jamie P Dwyer
Dialysis patients have absolute and functional iron deficiencies. Traditionally, oral iron preparations have been insufficient to maintain iron stores to support erythropoiesis, especially in the setting of the ubiquitous use of erythropoiesis-stimulating agents. This has led to the widespread adoption of intravenous iron protocols designed to maintain iron stores at levels that are much higher than for patients not on dialysis. These protocols are often developed by dialysis providers and may be largely independent of the treating nephrologist...
July 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27132828/dissolution-behaviour-of-ferric-pyrophosphate-and-its-mixtures-with-soluble-pyrophosphates-potential-strategy-for-increasing-iron-bioavailability
#6
Tian Tian, Elena Blanco, Stoyan K Smoukov, Orlin D Velev, Krassimir P Velikov
Ferric pyrophosphate (FePP) is a widely used iron source in food fortification and in nutritional supplements, due to its white colour, that is very uncommon for insoluble Fe salts. Although its dissolution is an important determinant of Fe adsorption in human body, the solubility characteristics of FePP are complex and not well understood. This report is a study on the solubility of FePP as a function of pH and excess of pyrophosphate ions. FePP powder is sparingly soluble in the pH range of 3-6 but slightly soluble at pH<2 and pH>8...
October 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27053382/cofortification-of-ferric-pyrophosphate-and-citric-acid-trisodium-citrate-into-extruded-rice-grains-doubles-iron-bioavailability-through-in-situ-generation-of-soluble-ferric-pyrophosphate-citrate-complexes
#7
Laura Hackl, Colin I Cercamondi, Christophe Zeder, Daniela Wild, Horst Adelmann, Michael B Zimmermann, Diego Moretti
BACKGROUND: Iron fortification of rice is a promising strategy for improving iron nutrition. However, it is technically challenging because rice is consumed as intact grains, and ferric pyrophosphate (FePP), which is usually used for rice fortification, has low bioavailability. OBJECTIVE: We investigated whether the addition of a citric acid/trisodium citrate (CA/TSC) mixture before extrusion increases iron absorption in humans from FePP-fortified extruded rice grains...
May 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26928401/transdermal-delivery-of-iron-using-soluble-microneedles-dermal-kinetics-and-safety
#8
Naresh Modepalli, H Nanjappa Shivakumar, Maeliosa T C McCrudden, Ryan F Donnelly, Ajay Banga, S Narasimha Murthy
Currently, the iron compounds are administered via oral and parenteral routes in patients of all ages, to treat iron deficiency. Despite continued efforts to supplement iron via these conventional routes, iron deficiency still remains the most prevalent nutritional disorder all over the world. Transdermal replenishment of iron is a novel, potential approach of iron replenishment. Ferric pyrophosphate (FPP) was found to be a suitable source of iron for transdermal replenishment. The safety of FPP was assessed in this project by challenging the dermal fibroblast cells with high concentration of FPP...
March 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26616335/new-options-for-iron-supplementation-in-maintenance-hemodialysis-patients
#9
REVIEW
Nosratola D Vaziri, Kamyar Kalantar-Zadeh, Jay B Wish
End-stage renal disease results in anemia caused by shortened erythrocyte survival, erythropoietin deficiency, hepcidin-mediated impairment of intestinal absorption and iron release, recurrent blood loss, and impaired responsiveness to erythropoiesis-stimulating agents (ESAs). Iron malabsorption renders oral iron products generally ineffective, and intravenous (IV) iron supplementation is required in most patients receiving maintenance hemodialysis (HD). IV iron is administered at doses far exceeding normal intestinal iron absorption...
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26579682/supplemental-iron-via-dialysate-a-novel-mode-of-delivery-for-hemodialysis-patients
#10
COMMENT
Iain C Macdougall
Gupta et al. describe a novel strategy for iron administration to hemodialysis patients, giving ferric pyrophosphate citrate via the dialysate. PRIME, a randomized controlled study comparing this technology against placebo, shows a 35% reduction in prescribed erythropoiesis-stimulating agent dose. The findings may be explained in part by a restrictive protocol for intravenous iron administration in the placebo group, producing lower ferritin levels. There were no obvious safety concerns. The general applicability of this technology, and its cost-effectiveness, are unclear at the present time...
November 2015: Kidney International
https://www.readbyqxmd.com/read/26405327/ombitasvir-paritaprevir-ritonavir-and-dasabuvir
#11
Dennis J Cada, James Leonard, Terri L Levien, Danial E Baker
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line...
May 2015: Hospital Pharmacy
https://www.readbyqxmd.com/read/26384126/-tolerability-of-iron-preparation-actiferol-fe%C3%A2-in-children-treated-for-iron-deficiency-anemia
#12
Teresa Jackowska, Alicja Sapała-Smoczyńska, Ewa Kamińska
INTRODUCTION: Iron de„ciency anemia is the most frequently occurring anemia during the childhood period. Supplementation with adequate doses of iron remains a basic method of prevention and treatment. The various available products containing iron are characterized by a different degree of patient tolerability. Actiferol Fe® is a micronized, dispersible ferric pyrophosphate which improves its water solubility, and therefore it has better absorption and bioavailability. AIM OF THE STUDY: The assessment of tolerability of Actiferol Fe® in children who were administered this product to treat or prevent of iron de„ciency anemia...
April 2015: Developmental Period Medicine
https://www.readbyqxmd.com/read/26377199/the-effect-of-iron-fortified-complementary-food-and-intermittent-preventive-treatment-of-malaria-on-anaemia-in-12-to-36-month-old-children-a-cluster-randomised-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Dominik Glinz, Richard F Hurrell, Mamadou Ouattara, Michael B Zimmermann, Gary M Brittenham, Lukas G Adiossan, Aurélie A Righetti, Burkhardt Seifert, Victorine G Diakité, Jürg Utzinger, Eliézer K N'Goran, Rita Wegmüller
BACKGROUND: Iron deficiency (ID) and malaria co-exist in tropical regions and both contribute to high rates of anaemia in young children. It is unclear whether iron fortification combined with intermittent preventive treatment (IPT) of malaria would be an efficacious strategy for reducing anaemia in young children. METHODS: A 9-month cluster-randomised, single-blinded, placebo-controlled intervention trial was carried out in children aged 12-36 months in south-central Côte d'Ivoire, an area of intense and perennial malaria transmission...
September 17, 2015: Malaria Journal
https://www.readbyqxmd.com/read/26345022/bioavailability-of-iron-in-multiple-fortified-milk
#14
Bhawana Sachdeva, Ravinder Kaushik, Sumit Arora, Suman Kapila
The objectives of the study were to evaluate the bioavailability of iron in milk fortified with ferric pyrophosphate (FPP) soluble and vitamin A acetate and to establish the role of vitamin A in enhancement of iron absorption. Balance indices viz. apparent digestibility coefficient, % retention/intake of iron and haematological parameters viz. blood haemoglobin, plasma ferritin, plasma transferrin and iron content in rat livers were analyzed to evaluate iron bioavailability. Anaemia was induced in one group of rats to evaluate the effect of iron status of body on iron absorption from diet...
September 2015: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/26203048/ferric-pyrophosphate-good-things-come-to-those-who-wait
#15
COMMENT
Lisa H Fell, Danilo Fliser, Gunnar H Heine
No abstract text is available yet for this article.
December 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26175145/ferric-pyrophosphate-citrate-triferic%C3%A2-administration-via-the-dialysate-maintains-hemoglobin-and-iron-balance-in-chronic-hemodialysis-patients
#16
RANDOMIZED CONTROLLED TRIAL
Steven N Fishbane, Ajay K Singh, Serge H Cournoyer, Kailash K Jindal, Paolo Fanti, Carrie D Guss, Vivian H Lin, Raymond D Pratt, Ajay Gupta
BACKGROUND: Administration of ferric pyrophosphate citrate (FPC, Triferic™) via hemodialysate may allow replacement of ongoing uremic and hemodialysis-related iron losses. FPC donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration. METHODS: Two identical Phase 3, randomized, placebo-controlled trials (CRUISE 1 and 2) were conducted in 599 iron-replete chronic hemodialysis patients. Patients were dialyzed with dialysate containing 2 µM FPC-iron or standard dialysate (placebo) for up to 48 weeks...
December 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26154926/ferric-pyrophosphate-citrate-administered-via-dialysate-reduces-erythropoiesis-stimulating-agent-use-and-maintains-hemoglobin-in-hemodialysis-patients
#17
RANDOMIZED CONTROLLED TRIAL
Ajay Gupta, Vivian Lin, Carrie Guss, Raymond Pratt, T Alp Ikizler, Anatole Besarab
Ferric pyrophosphate citrate (FPC) is a water-soluble iron salt administered via dialysate to supply iron directly to transferrin. The PRIME study tested whether treatment with FPC could reduce prescribed erythropoiesis-stimulating agent (ESA) use and maintain hemoglobin in hemodialysis patients. This 9-month, randomized, placebo-controlled, double-blind, multicenter clinical study included 103 patients undergoing hemodialysis 3-4 times weekly. The FPC group received dialysate containing 2 μmol/l of iron...
November 2015: Kidney International
https://www.readbyqxmd.com/read/26149783/transdermal-iron-replenishment-therapy
#18
Naresh Modepalli, H N Shivakumar, K L Paranjothy Kanni, S Narasimha Murthy
Iron deficiency anemia is one of the major nutritional deficiency disorders. Iron deficiency anemia occurs due to decreased absorption of iron from diet, chronic blood loss and other associated diseases. The importance of iron and deleterious effects of iron deficiency anemia are discussed briefly in this review followed by the transdermal approaches to deliver iron. Transdermal delivery of iron would be able to overcome the side effects associated with conventional oral and parenteral iron therapy and improves the patient compliance...
2015: Therapeutic Delivery
https://www.readbyqxmd.com/read/25830598/iron-bioavailability-in-iron-fortified-cereal-foods-the-contribution-of-in-vitro-studies
#19
Késia Diego Quintaes, Reyes Barberá, Antonio Cilla
Iron deficiency anemia is the most common nutritional deficiency in humans. Not all dietary ingested iron, heme or non-heme, will be available to absorption and negative imbalance between iron requirements and absorption leads to iron deficiency and/or anemia. The recommended iron values usually are based on the genetic and on diet iron-bioavailability, which can be considered as the principal factor that change among the cultures and influences the distinct levels of recommendation among countries. Dietary changes present practical limitations due to be difficult to change food habits...
April 1, 2015: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/25473976/minimum-inhibitory-concentration-distribution-in-environmental-legionella-spp-isolates
#20
Vassilios Sandalakis, Dimosthenis Chochlakis, Ioannis Goniotakis, Yannis Tselentis, Anna Psaroulaki
In Greece standard tests are performed in the watering and cooling systems of hotels' units either as part of the surveillance scheme or following human infection. The purpose of this study was to establish the minimum inhibitory concentration (MIC) distributions of environmental Legionella isolates for six antimicrobials commonly used for the treatment of Legionella infections, by MIC-test methodology. Water samples were collected from 2004 to 2011 from 124 hotels from the four prefectures of Crete (Greece)...
December 2014: Journal of Water and Health
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