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https://www.readbyqxmd.com/read/28231509/a-single-injection-of-protein-loaded-coacervate-gel-significantly-improves-cardiac-function-post-infarction
#1
H K Awada, D W Long, Z Wang, M P Hwang, K Kim, Y Wang
After myocardial infarction (MI), the heart undergoes fibrotic pathological remodeling instead of repair and regeneration. With multiple pathologies developing after MI, treatment using several proteins is expected to address this range of pathologies more effectively than a single-agent therapy. A factorial design of experiments study guided us to combine three complementary factors in one injection: tissue inhibitor of metalloproteinases-3 (TIMP-3) was embedded in a fibrin gel for signaling in the initial phase of the treatment, while basic fibroblast growth factor (FGF-2) and stromal cell-derived factor 1-alpha (SDF-1α) were embedded in heparin-based coacervates for sustained release and distributed within the same fibrin gel to exert their effects over a longer period...
February 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28229248/promoting-social-nurturance-and-positive-social-environments-to-reduce-obesity-in-high-risk-youth
#2
REVIEW
Dawn K Wilson, Allison M Sweeney, Heather Kitzman-Ulrich, Haylee Gause, Sara M St George
Nurturing environments within the context of families, schools, and communities all play an important role in enhancing youth's behavioral choices and health outcomes. The increasing prevalence rates of obesity among youth, especially among low income and ethnic minorities, highlight the need to develop effective and innovative intervention approaches that promote positive supportive environments across different contexts for at-risk youth. We propose that the integration of Social Cognitive Theory, Family Systems Theory, and Self-Determination Theory offers a useful framework for understanding how individual, family, and social-environmental-level factors contribute to the development of nurturing environments...
February 22, 2017: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/28228124/mediators-of-the-association-between-parental-education-and-breakfast-consumption-among-adolescents-the-essens-study
#3
Mekdes K Gebremariam, Sigrun Henjum, Elisabeth Hurum, Jorunn Utne, Laura Terragni, Liv Elin Torheim
BACKGROUND: Regular breakfast consumption has several health benefits. However, breakfast skipping is common among adolescents, in particular among those with a low socioeconomic background. The aims of the study were to explore individual and home environmental correlates of breakfast consumption, and to assess their potential mediating role in the association between parental education and breakfast consumption. METHODS: A cross-sectional study including 706 adolescents with a mean age of 13...
February 23, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28227462/auto-adjusting-mandibular-repositioning-device-for-in-home-use
#4
R Brugarolas, J M Valero-Sarmiento, A Bozkurt, G K Essick, R Brugarolas, J M Valero-Sarmiento, A Bozkurt, G K Essick, J M Valero-Sarmiento, G K Essick, R Brugarolas, A Bozkurt
Obstructive Sleep Apnea (OSA) is a form of respiratory dysfunction that affects 20% of adults in the world. Among the first-line treatments that are used to mitigate the effects of OSA are continuous positive airway pressure (CPAP) and mandibular repositioning devices (MRD). Although CPAP provides a more efficacious therapy than MRDs, recent studies suggest that both are comparable in overall effectiveness due to greater patient preference and adherence to MRD therapy. In this paper, we present the Auto-Positioner, a novel add-on for MRDs that adjusts the extent to which the mandible (lower jaw) is advanced in response to respiratory signals indicating labored breathing during sleep, and to changes in sleeping position known to affect individual patient's airway patency...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227321/fall-detection-algorithms-for-real-world-falls-harvested-from-lumbar-sensors-in-the-elderly-population-a-machine-learning-approach
#5
Alan K Bourke, Jochen Klenk, Lars Schwickert, Kamiar Aminian, Espen A F Ihlen, Sabato Mellone, Jorunn L Helbostad, Lorenzo Chiari, Clemens Becker, Alan K Bourke, Jochen Klenk, Lars Schwickert, Kamiar Aminian, Espen A F Ihlen, Sabato Mellone, Jorunn L Helbostad, Lorenzo Chiari, Clemens Becker, Lorenzo Chiari, Lars Schwickert, Kamiar Aminian, Clemens Becker, Jorunn L Helbostad, Jochen Klenk, Alan K Bourke, Sabato Mellone, Espen A F Ihlen
Automatic fall detection will promote independent living and reduce the consequences of falls in the elderly by ensuring people can confidently live safely at home for linger. In laboratory studies inertial sensor technology has been shown capable of distinguishing falls from normal activities. However less than 7% of fall-detection algorithm studies have used fall data recorded from elderly people in real life. The FARSEEING project has compiled a database of real life falls from elderly people, to gain new knowledge about fall events and to develop fall detection algorithms to combat the problems associated with falls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226832/detection-of-compensatory-balance-responses-using-wearable-electromyography-sensors-for-fall-risk-assessment
#6
Mina Nouredanesh, Sunil L Kukreja, James Tung, Mina Nouredanesh, Sunil L Kukreja, James Tung, Mina Nouredanesh, Sunil L Kukreja, James Tung
Loss of balance is prevalent in older adults and populations with gait and balance impairments. The present paper aims to develop a method to automatically distinguish compensatory balance responses (CBRs) from normal gait, based on activity patterns of muscles involved in maintaining balance. In this study, subjects were perturbed by lateral pushes while walking and surface electromyography (sEMG) signals were recorded from four muscles in their right leg. To extract sEMG time domain features, several filtering characteristics and segmentation approaches are examined...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226559/testing-non-wearable-fall-detection-methods-in-the-homes-of-older-adults
#7
Marjorie Skubic, Bradford H Harris, Erik Stone, K C Ho, Bo-Yu Su, Marilyn Rantz, Marjorie Skubic, Bradford H Harris, Erik Stone, K C Ho, Bo-Yu Su, Marilyn Rantz, Erik Stone, Bo-Yu Su, Bradford H Harris, Marjorie Skubic, Marilyn Rantz, K C Ho
In this paper, we describe two longitudinal studies in which fall detection sensor technology was tested in the homes of older adults. The first study tested Doppler radar, a two-webcam system, and a depth camera system in ten apartments for two years. This continuous data collection allowed us to investigate the real-world setting of target users and compare the advantages and limitations of each sensor modality. Based on this study, the depth camera was chosen for a current ongoing study in which depth camera systems have been installed in 94 additional older adult apartments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226181/use-of-self-collected-capillary-blood-samples-for-islet-autoantibody-screening-in-relatives-a-feasibility-and-acceptability-study
#8
Y Liu, L E Rafkin, D Matheson, C Henderson, D Boulware, R E J Besser, C Ferrara, L Yu, A K Steck, P J Bingley
AIMS: To evaluate the feasibility of using self-collected capillary blood samples for islet autoantibody testing to identify risk in relatives of people with Type 1 diabetes. METHODS: Participants were recruited via the observational TrialNet Pathway to Prevention study, which screens and monitors relatives of people with Type 1 diabetes for islet autoantibodies. Relatives were sent kits for capillary blood collection, with written instructions, an online instructional video link and a questionnaire...
February 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28222775/modification-of-the-association-between-recreational-physical-activity-and-survival-after-breast-cancer-by-promoter-methylation-in-breast-cancer-related-genes
#9
Lauren E McCullough, Jia Chen, Yoon Hee Cho, Nikhil K Khankari, Patrick T Bradshaw, Alexandra J White, Susan L Teitelbaum, Mary Beth Terry, Alfred I Neugut, Hanina Hibshoosh, Regina M Santella, Marilie D Gammon
BACKGROUND: Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast cancer-related genes, as well as global methylation, may modify the association between prediagnostic recreational physical activity (RPA) and breast cancer mortality. METHODS: Using a population-based sample of 1254 women diagnosed with first primary breast cancer, we examined modification of the RPA-mortality association by gene-specific promoter methylation and global methylation...
February 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28222301/impact-of-home-visit-capacity-on-genetic-association-studies-of-late-onset-alzheimer-s-disease
#10
David W Fardo, Laura E Gibbons, Shubhabrata Mukherjee, M Maria Glymour, Wayne McCormick, Susan M McCurry, James D Bowen, Eric B Larson, Paul K Crane
INTRODUCTION: Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. METHODS: We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308)...
February 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28221978/quantitative-microbial-risk-assessment-for-escherichia-coli-o157-h7-in-fresh-cut-lettuce
#11
Hao Pang, Elisabetta Lambertini, Robert L Buchanan, Donald W Schaffner, Abani K Pradhan
Leafy green vegetables, including lettuce, are recognized as potential vehicles for foodborne pathogens such as Escherichia coli O157:H7. Fresh-cut lettuce is potentially at high risk of causing foodborne illnesses, as it is generally consumed without cooking. Quantitative microbial risk assessments (QMRAs) are gaining more attention as an effective tool to assess and control potential risks associated with foodborne pathogens. This study developed a QMRA model for E. coli O157:H7 in fresh-cut lettuce and evaluated the effects of different potential intervention strategies on the reduction of public health risks...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221878/prediction-of-escherichia-coli-o157-h7-salmonella-and-listeria-monocytogenes-growth-in-leafy-greens-without-temperature-control
#12
Abhinav Mishra, Miao Guo, Robert L Buchanan, Donald W Schaffner, Abani K Pradhan
A recent study by the Centers for Disease Control and Prevention reported that between 1998 and 2008, leafy greens outbreaks accounted for 22.3% of foodborne outbreaks in the United States. Several studies on the growth of bacteria at different temperatures have been conducted; however, there is a need for the prediction of bacterial growth when leafy greens are transported without temperature control. Food products, when taken out of refrigeration, undergo a temperature change, with the rate of temperature change being proportional to the difference in the temperature of food and its surroundings...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221672/can-braden-score-predict-outcomes-for-hospitalized-heart-failure-patients
#13
Brian Bandle, Kelsey Ward, Sung-Joon Min, Cynthia Drake, Colleen K McIlvennan, David Kao, Heidi L Wald
BACKGROUND: Braden score is a routine assessment of pressure ulcer risk hypothesized to identify the frail phenotype. OBJECTIVES: To investigate the predictive utility of the Braden score on outcomes of inpatients with heart failure (HF). DESIGN: Retrospective cohort study. SETTING: An academic medical center between January 1, 2012 and June 30, 2013. PARTICIPANTS: 642 inpatients with a primary diagnosis of HF (ICD-9 428)...
February 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28217864/-sounds-a-bit-crazy-but-it-was-almost-more-personal-a-qualitative-study-of-patient-and-clinician-experiences-of-physical-therapist-prescribed-exercise-for-knee-osteoarthritis-via-skype%C3%A2
#14
R S Hinman, R K Nelligan, K L Bennell, C Delany
OBJECTIVES: Explore patients' and physical therapists' experience with Skype™ for exercise management of knee OA. METHODS: Qualitative study. The Donabedian model for quality assessment in health care (structure, process and outcomes) informed semi-structured individual interview questions. Twelve purposively-sampled patients with knee OA who received physical therapist-prescribed exercise over Skype™, and all therapists (n=8) who delivered the intervention, in a clinical trial were interviewed about their experiences...
February 19, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28215655/the-caregiver-perspective-on-unscheduled-72-hour-return-visits-to-pediatric-acute-care-sites-a-focus-on-discharge-processes
#15
Nidhya Navanandan, Sarah K Schmidt, Natasha Cabrera, Michael C DiStefano, Rakesh D Mistry
OBJECTIVE: To characterize pediatric caregivers' reasons for 72-hour emergency department (ED) and urgent care (UC) returns. METHODS: A sample of caregivers returning within 72 hours of initial visit to a pediatric ED or affiliated UC site were surveyed from 11/14-6/15; patients evaluated at outside ED/UCs, scheduled for return, or non-English/Spanish speaking were excluded. Caregiver surveys underwent item generation, validation, and pilot testing. Survey items included caregiver reasons for unscheduled returns, with a specific assessment of delivery of key components of discharge instructions (diagnosis, duration of illness, home care, return precautions)...
February 12, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28215372/the-managing-epilepsy-well-network-advancing-epilepsy-self-management
#16
EDITORIAL
Martha Sajatovic, Barbara C Jobst, Ross Shegog, Yvan A Bamps, Charles E Begley, Robert T Fraser, Erica K Johnson, Dilip K Pandey, Rakale C Quarells, Peter Scal, Tanya M Spruill, Nancy J Thompson, Rosemarie Kobau
Epilepsy, a complex spectrum of disorders, affects about 2.9 million people in the U.S. Similar to other chronic disorders, people with epilepsy face challenges related to management of the disorder, its treatment, co-occurring depression, disability, social disadvantages, and stigma. Two national conferences on public health and epilepsy (1997, 2003) and a 2012 IOM report on the public health dimensions of epilepsy highlighted important knowledge gaps and emphasized the need for evidence-based, scalable epilepsy self-management programs...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28209484/successful-provision-of-inter-hospital-extracorporeal-cardiopulmonary-resuscitation-for-acute-post-partum-pulmonary-embolism
#17
C McDonald, J Laurie, S Janssens, C Zazulak, P Kotze, K Shekar
Mortality during pregnancy in a well-resourced setting is rare, but acute pulmonary embolism is one of the leading causes. We present the successful use of extracorporeal cardiopulmonary resuscitation (eCPR) in a 22-year old woman who experienced cardiopulmonary collapse following urgent caesarean section in the setting of a sub-massive pulmonary embolus. Resources and personnel to perform eCPR were not available at the maternity hospital and were recruited from an adjacent pediatric hospital. Initial care used low blood flow extracorporeal membrane oxygenation (ECMO) with pediatric ECMO circuitry, which was optimized when the team from a nearby adult cardiac hospital arrived...
January 9, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28207892/triethylene-glycol-an-active-component-of-ashwagandha-withania-somnifera-leaves-is-responsible-for-sleep-induction
#18
Mahesh K Kaushik, Sunil C Kaul, Renu Wadhwa, Masashi Yanagisawa, Yoshihiro Urade
Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whole plant extract of Ashwagandha (Withania somnifera) has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28202088/what-influences-the-home-range-size-of-free-roaming-domestic-dogs
#19
S Dürr, N K Dhand, C Bombara, S Molloy, M P Ward
In many regions of the world domestic dogs are free roaming and live in close relationship with humans. These free-roaming domestic dogs (FRDD) can cause public health problems such as dog bites and transmission of infectious diseases. To effectively control diseases transmitted by FRDD, knowledge on the dogs' behaviour is required. To identify predictors of home range (HR) size, we collected global positioning system data from 135 FRDD living in eight Aboriginal and Torres Strait Islander communities in Northern Australia...
February 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28199850/flow-dynamics-and-hspc-homing-in-bone-marrow-microvessels
#20
M Gabriele Bixel, Anjali P Kusumbe, Saravana K Ramasamy, Kishor K Sivaraj, Stefan Butz, Dietmar Vestweber, Ralf H Adams
Measurements of flow velocities at the level of individual arterial vessels and sinusoidal capillaries are crucial for understanding the dynamics of hematopoietic stem and progenitor cell homing in the bone marrow vasculature. We have developed two complementary intravital two-photon imaging approaches to determine blood flow dynamics and velocities in multiple vessel segments by capturing the motion of red blood cells. High-resolution spatiotemporal measurements through a cranial window to determine short-time dynamics of flowing blood cells and repetitive centerline scans were used to obtain a detailed flow-profile map with hemodynamic parameters...
February 14, 2017: Cell Reports
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