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Stanozolol

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https://www.readbyqxmd.com/read/29717770/stanozolol-administration-combined-with-exercise-leads-to-decreased-telomerase-activity-possibly-associated-with-liver-aging
#1
Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N Tzatzarakis, Christina Tsitsimpikou, Polychronis D Stivaktakis, Dimitrios Tsoukalas, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the most well recognized target organ. In the present study, the hepatic effects of stanozolol administration in rats at high doses resembling those used for doping purposes were investigated, in the presence or absence of exercise...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29560159/prevalence-and-awareness-of-anabolic-androgenic-steroids-aas-among-gymnasts-in-the-western-province-of-riyadh-saudi-arabia
#2
Khaled Abdullah Al Bishi, Ayman Afify
Background: Anabolic Androgenic Steroids (AAS) are synthetic derivatives of the male sex hormone (testosterone) that are increasingly used by athletes as performance enhancing drugs to increase muscle mass and strength. Multiple health adverse effects may be caused by its non-medical use. Several international and regional studies showed the high prevalence of AAS usage and low level of awareness of it among different populations. Objective: To estimate the prevalence of AAS and to determine the level of awareness toward it among gymnasts in the western province of Riyadh...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29554899/effects-of-stanozolol-on-normal-and-il-1%C3%AE-stimulated-equine-chondrocytes-in-vitro
#3
Mariana Castro Martins, Mandy J Peffers, Katie Lee, Luis M Rubio-Martinez
BACKGROUND: Intra-articular administration of stanozolol has shown promising results by improving the clinical management of lameness associated with naturally-occurring osteoarthritis (OA) in horses, and by decreasing osteophyte formation and subchondral bone reaction in sheep following surgically induced OA. However, there is limited evidence on the anti-inflammatory and modulatory properties of stanozolol on articular tissues. The objective of the current study was to evaluate the effects of stanozolol on chondrocyte viability and gene expression in normal equine chondrocytes and an inflammatory in vitro system of OA (interleukin-1β (IL-1β) treated chondrocytes)...
March 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29477345/effects-of-stanozolol-on-apoptosis-mechanisms-and-oxidative-stress-in-rat-cardiac-tissue
#4
Mehtap Kara, Eren Ozcagli, Tuğba Kotil, Buket Alpertunga
Stanozolol is a widely used 17α-alkylated anabolic androgenic steroid (AAS) derivative. Despite stanozolol's adverse effects, its effect on oxidative stress parameters and mitochondrial apoptosis pathway is not clearly defined. In our study, thirty four male Sprague-Dawley rats were divided into 5 groups as control (C), vehicle control (VC), steroid (ST), vehicle control-exercise (VCE), and steroid-exercise (STE). Animals were subcutaneously administered stanozolol 5 mg/kg in steroid groups and propylene glycol 1 ml/kg in the vehicle-control groups...
June 2018: Steroids
https://www.readbyqxmd.com/read/29448243/impact-of-health-authority-control-measures-aimed-at-reducing-the-illicit-use-of-anabolic-androgenic-steroids
#5
Raquel Vázquez-Mourelle, Eduardo Carracedo-Martinez, Adolfo Figueiras
OBJECTIVE: To evaluate two interventions on anabolic-androgenic-steroids (AAS) dispensation in retail pharmacies. MATERIAL AND METHODS: The study was conducted in a north-western region of Spain. Data were the AAS supplied by wholesale drug distributors to retail pharmacies over a period of 102 months. It is designed as an ecological time-series study; the dependent variables were daily defined doses per 1,000 inhabitants per day of each drug. The two interventions evaluated were: (1) an inspection program intended for those retail pharmacies where there was an irregular dispensation and (2) a regulation put forth forcing these pharmacies to carry out additional registers...
2018: European Addiction Research
https://www.readbyqxmd.com/read/29430877/detection-of-prohibited-substances-in-equine-hair-by-ultra-high-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry-application-to-doping-control-samples
#6
B Gray, M Viljanto, E Menzies, L Vanhaecke
The detection of drugs in human hair samples has been performed by laboratories around the world for many years and the matrix is popular in disciplines, such as workplace drug testing. To date, however, hair has not become a routinely utilised matrix in sports drug detection. The analysis of hair samples offers several potential advantages to doping control laboratories, not least of which are the greatly extended detection window and the ease of sample collection and storage. This article describes the development, validation, and utilisation of a sensitive ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS) method for the detection of 50 compounds...
February 12, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29278383/an-ft-raman-ft-ir-and-quantum-chemical-investigation-of-stanozolol-and-oxandrolone
#7
Tibebe Lemma, Fabiano de Barros Souza, Claudio A Tellez Soto, Airton A Martin
We have studied the Fourier Transform Infrared (FT-IR) and the Fourier transform Raman (FT-Raman) spectra of stanozolol and oxandrolone, and we have performed quantum chemical calculations based on the density functional theory (DFT) with a B3LYP/6-31G (d, p) level of theory. The FT-IR and FT-Raman spectra were collected in a solid phase. The consistency between the calculated and experimental FT-IR and FT-Raman data indicates that the B3LYP/6-31G (d, p) can generate reliable geometry and related properties of the title compounds...
December 26, 2017: Biosensors
https://www.readbyqxmd.com/read/29070131/-efficacy-of-shengxue-mixture-combined-with-intraosseous-infusion-for-treatment-of-aplastic-anemia
#8
Shan-Xi Liu, Yi-Guo Liu, Peng-Hui Wang, Mao-Feng Qi, Meng Luo
OBJECTIVE: To evaluate the efficacy and safety of Shengxue mixture combined with intraosseous blood infusion for treatment of aplastic anemia patients. METHODS: From 2011 to 2015, Institute of blood diseases of Shaanxi Medical University admitted 53 patients with aplastic anemia. The patients were treated with shengxue mixture 200 ml, orally, twice a day. Stanozolol tablets, Adult 2 mg, three times a day, mycophenolate mofetil 1.0 g, twice a day. Intraosseous infusion of the following medicine were administered in patients: recombinant human EPO 10000 U, recombinant human G-CSF 450 µg, recombinant human IL-11 4...
October 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29030156/applicability-of-an-innovative-steroid-profiling-method-to-determine-synthetic-growth-promoter-abuse-in-cattle
#9
M H Blokland, E F van Tricht, L A van Ginkel, S S Sterk
A robust LC-MS/MS method was developed to quantify a large number of phase I and phase II steroids in urine. The decision limit is for most compounds lower than 1ngml-1 with a measurement uncertainty smaller than 30%. The method is fully validated and was applied to assess the influence of administered synthetic steroids and beta-agonists on the steroidogenesis. From three animal experiments, clenbuterol, diethylstilbestrol and stanozolol, the steroid profiles in urine of bovine animals were compared before and after treatment...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28987069/is-zebrafish-danio-rerio-a-tool-for-human-like-metabolism-study
#10
Carina de Souza Anselmo, Vinicius Figueiredo Sardela, Bernardo Fonseca Matias, Amanda Reis de Carvalho, Valeria Pereira de Sousa, Henrique Marcelo Gualberto Pereira, Francisco Radler de Aquino Neto
One of the greatest challenges in anti-doping science is the large number of substances available and the difficulty in finding the best analytical targets to detect their misuse. Therefore, metabolism studies involving prohibited substances are fundamental. However, metabolism studies in humans could face an important ethical bottleneck, especially for non-approved substances. An emerging model for metabolism assessment is the zebrafish, due to its genetic similarities with humans. In the present study, the ability of adult zebrafish to produce metabolites of sibutramine and stanozolol, substances with a well-known metabolism that are widely used as doping agents in sports, was evaluated...
November 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28746051/stanozolol-soaked-grafts-enhance-new-bone-formation-in-rat-calvarial-critical-size-defects
#11
G Ghiacci, G Graiani, A Cacchioli, C Galli, S Lumetti, F Ravanetti, L Elviri, E Manfredi, G M Macaluso, R Sala
Androgen hormones play a significant role in regulating bone morphogenesis and in maintaining bone homeostasis throughout life. This study aimed to investigate the local effects of the non-aromatizable androgen stanozolol (ST) on bone regeneration in rats. Bilateral critical-size defects were created in the parietal bone of 26 male Wistar rats: the defect on one side was filled with a deproteinized bovine bone scaffold (DBB) soaked in ST solution (test) and the contralateral with DBB alone (control). Samples were collected at one month and three months...
July 26, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28663159/synchronous-solid-pseudopapillary-tumor-and-insulinoma-in-an-adolescent-men1-patient-presenting-with-diagnostic-dilemmas
#12
Ahmet Uçar, Banu Özgüven, Muharrem Battal, Ferda Alparslan Pınarlı, Evrim Özmen, Aylin Yetim, Yasin Yılmaz
Multiple endocrine neoplasia (MEN1) is a rare autosomal dominant disorder characterized by primary hyperparathyroidism, enteropancreatic neuroendocrine tumors, and anterior pituitary adenomas. A 16-year-old male presented to the emergency outpatient clinic with tonic convulsions. Physical examination in the postconvulsive period was unremarkable and revealed a muscular, postpubertal adolescent. Biochemical tests at admission were consistent with hyperinsulinemic hypoglycemia and remarkable for elevated levels of liver transaminases and creatine kinase...
December 15, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28648787/online-turbulent-flow-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry-for-high-throughput-screening-of-anabolic-steroids-in-horse-urine
#13
Hyun Du Shin, Joon Hyuk Suh, Junghyun Kim, Hyun-Deok Cho, Su Duk Lee, Kwan Seok Han, Yu Wang, Sang Beom Han
A high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine by online turbulent flow extraction coupled with liquid chromatography-tandem mass spectrometry was developed. The use of turbulent flow chromatography could simplify pretreatment of horse urine, which has complex matrices as well as high viscosity...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28604639/inhibitory-effects-of-diclofenac-on-steroid-glucuronidation-in-vivo-do-not-affect-hair-based-doping-tests-for-stanozolol
#14
Gergely Zachár, Naved I K Deshmukh, Andrea Petróczi, Andrea D Székely, Iltaf Shah, James Barker, Declan P Naughton
In vitro studies show that diclofenac inhibits enzymatic steroid glucuronidation. This study was designed to investigate the influence of diclofenac on the excretion of stanozolol and 3'-hydroxystanozolol via analyses in hair, blood and urine in vivo in a rat study. Brown Norway rats were administered with stanozolol (weeks 1-3) and diclofenac (weeks 1-6). Weekly assessment of steroid levels in hair was complemented with spot urine and serum tests. Levels of both stanozolol and 3'-hydroxystanozolol steadily increased in hair during stanozolol treatment and decreased post-treatment, but remained readily detectable for 6 weeks...
June 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28352339/determination-of-dna-damage-and-telomerase-activity-in-stanozolol-treated-rats
#15
Mehtap Kara, Eren Ozcagli, Persefoni Fragkiadaki, Tugba Kotil, Polychronis D Stivaktakis, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic androgenic steroids (AAS) are performance-enhancing drugs commonly abused by atheletes. Stanozolol is a synthetic testosterone-derived anabolic steroid. Although it is well known that AAS have several side-effects, there are only few toxicological studies available on the toxic effects and mechanisms of action of stanozolol. The aim of this study was to investigate the genotoxic effects of stanozolol and to determine its effects on telomerase activity in Sprague-Dawley male rats. For this purpose, 34 male rats were divided into 5 groups as follows: i) the control group (n=5); ii) the propylene glycol (PG)-treated group (n=5); iii) the stanozolol-treated group (n=8); iv) the PG-treated group subjected to exercise (n=8); and v) the stanozolol-treated group subjected to exercise (n=8)...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28236045/detection-and-quantification-of-12-anabolic-steroids-and-analogs-in-human-whole-blood-and-20-in-hair-using-lc-hrms-ms-application-to-real-cases
#16
Nicolas Fabresse, Stanislas Grassin-Delyle, Isabelle Etting, Jean-Claude Alvarez
We developed and validated a method to detect and quantify 12 anabolic steroids in blood (androstenedione, dihydrotestosterone, boldenone, epitestosterone, mesterolone, methandienone, nandrolone, stanozolol, norandrostenedione, tamoxifene, testosterone, trenbolone) and eight more in hair samples (nandrolone phenylpropionate, nandrolone decanoate, testosterone propionate, testosterone benzoate, testosterone cypionate, testosterone decanoate, testosterone phenylpropionate, testosterone undecanoate) using liquid chromatography coupled to high-resolution mass spectrometry...
July 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28105335/detection-of-stanozolol-in-the-urine-of-athletes-at-a-pg-level-the-possibility-of-passive-exposure
#17
Christina Tsitsimpikou, Konstantinos Tsarouhas, Demetrios A Spandidos, Aristides M Tsatsakis
Stanozolol is a synthetic heterocyclic steroid with anabolic and androgenic properties, which has been abused by several high-profile professional athletes. Stanozolol is also used in veterinary medicine to increase appetite, cause weight gain and treat certain types of anemia. The detection of stanozolol metabolites in human urine for doping control purposes depends on the analytical method applied. The most commonly applied methods in the World Anti-Doping Agency (WADA)-accredited doping control laboratories are gas chromatography/high-resolution mass spectrometry (GC/HRMS) or gas chromatography-mass spectrometry (GC/MS/MS)...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28009930/incorporation-of-a-metabolizing-system-in-biodetection-assays-for-endocrine-active-substances
#18
Julie Mollergues, Barbara van Vugt-Lussenburg, Christian Kirchnawy, Reka Anna Bandi, Rosan B van der Lee, Maricel Marin-Kuan, Benoit Schilter, Karma C Fussell
The use of in vitro assays is important for the biodetection of endocrine active substances (EAS), reducing and replacing the in vivo studies required for regulatory assessment. However, this approach often fails to take into account the role of biotransformation on the activity of the test substances. A method incorporating an S9 metabolic system into the CALUX-reporter gene assays for estrogen receptor α- and anti-androgen receptor -mediated activities has been developed. Methoxychlor, which is known to exhibit increased estrogenic and anti-androgenic activities after biotransformation, was used to set up the method in ERa and anti-AR CALUX...
December 22, 2016: ALTEX
https://www.readbyqxmd.com/read/27896593/biochemical-and-oxidative-stress-markers-in-the-liver-and-kidneys-of-rats-submitted-to-different-protocols-of-anabolic-steroids
#19
Guilherme Lopes Dornelles, Andressa Bueno, Juliana Sorraila de Oliveira, Aleksandro Schafer da Silva, Raqueli Teresinha França, Cássia Bagolin da Silva, Márcia Silveira Netto Machado, Letícia do Santos Petry, Fátima Husein Abdalla, Cibele Lima Lhamas, Cinthia Melazzo de Andrade
The objective of this study was to evaluate the effects of different protocols (P1, P2, and P3) of boldenone undecylenate (BU) and stanozolol (ST) on markers of liver and kidney function and variables of oxidative stress in these organs. For this, 54 male Wistar rats were divided into nine groups of six animals each. Each animal received intramuscularly 5.0 mg kg(-1) of BU or ST once a week for 4 weeks (P1); 2.5 mg kg(-1) of BU or ST once a week for 8 weeks (P2); and 1.25 mg kg(-1) of BU or ST once a week for 12 weeks (P3)...
January 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27866079/multimodal-plasmonic-biosensing-nanostructures-prepared-by-dna-directed-immobilization-of-multifunctional-dna-gold-nanoparticles
#20
Nuria Tort, J-Pablo Salvador, M-Pilar Marco
Biofunctional multimodal plasmonic nanostructures suitable for multiplexed localized surface plasmon resonance (LSPR) biosensing have been created by DNA-directed immobilization (DDI) of two distinct multifunctional biohybrid gold nanoparticles. Gold nanoparticles (AuNP) of distinct sizes, and therefore showing distinct plasmon resonant peaks (RP), have been biofunctionalized and codified with two different single stranded-DNA (ssDNA) chains. One of these oligonucleotide chains has been specifically designed to direct each AuNP to a distinct location of the surface of a DNA microarray chip through specific hybridization with complementary oligonucleotide strands...
April 15, 2017: Biosensors & Bioelectronics
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