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https://www.readbyqxmd.com/read/29678513/review-of-blood-based-colorectal-cancer-screening-how-far-are-circulating-cell-free-dna-methylation-markers-from-clinical-implementation
#1
REVIEW
Mai-Britt Worm Ørntoft
Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide, and late stages (III-IV) in particular have low 5-year survival rates. Stage shifting by CRC screening programs has proven effective by decreasing morbidity and mortality and in many countries national CRC screening programs have been implemented. Currently, European, Asian, and American authorities recommend screening for CRC using fecal occult blood testing, sigmoidoscopy, or colonoscopy. Because these approaches all have weaknesses (eg, poor compliance, high costs, test invasiveness), much effort has been put into the development of alternative screening approaches, many of which are blood-based...
March 2, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29671413/non-variceal-upper-gastrointestinal-bleeding
#2
REVIEW
Angel Lanas, Jean-Marc Dumonceau, Richard H Hunt, Mitsuhiro Fujishiro, James M Scheiman, Ian M Gralnek, Helen E Campbell, Alaa Rostom, Càndid Villanueva, Joseph J Y Sung
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori infection or use of NSAIDs and low-dose aspirin (LDA), are the most common cause. Although the incidence and mortality associated with NVUGIB have been decreasing owing to considerable advances in the prevention and management of NVUGIB over the past 20 years, it remains a common clinical problem with an annual incidence of ∼67 per 100,000 individuals in the United States in 2012...
April 19, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29658767/quality-indicators-in-colonoscopy-the-colonoscopy-procedure
#3
Antonio Sánchez Del Río, Shirley Pérez Romero, Julio López-Picazo, Fernando Alberca de Las Parras, Javier Júdez, Joaquín León Molina
The aim of the project this paper is part of was to propose quality and safety procedures and indicators to facilitate quality improvement in digestive endoscopy units. In this second issue, procedures and indicators are suggested regarding colonoscopy. First, a diagram charting the previous and subsequent steps of colonoscopy was designed. A group of experts in health care quality and/or endoscopy, under the auspices of the Sociedad Española de Patología Digestiva (SEPD), performed a qualitative review of the literature regarding colonoscopy-related quality indicators...
April 16, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29655833/development-of-evidence-based-surveillance-intervals-following-radiofrequency-ablation-of-barrett-s-esophagus
#4
Cary C Cotton, Rehan Haidry, Aaron P Thrift, Laurence Lovat, Nicholas J Shaheen
BACKGROUND AND AIMS: Barrett's esophagus (BE) recurs in 25% or more of patients treated successfully with radiofrequency ablation (RFA), so surveillance endoscopy is recommended after complete eradication of intestinal metaplasia (CEIM). The frequency of surveillance is informed only by expert opinion. We aimed to model the incidence of neoplastic recurrence, validate the model in an independent cohort, and propose evidence-based surveillance intervals. METHODS: We collected data from the United States Radiofrequency Ablation Registry (US RFA, 2004-2013) and the United Kingdom National Halo Registry (UK NHR, 2007-2015) to build and validate models to predict the incidence of neoplasia recurrence following initially successful RFA...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29625137/sensitivity-of-non-contrast-computed-tomography-for-small-renal-calculi-with-endoscopy-as-the-gold-standard
#5
Naeem Bhojani, Jessica E Paonessa, Marawan M El Tayeb, James C Williams, Tariq A Hameed, James E Lingeman
OBJECTIVES: To compare the sensitivity of non-contrast CT to endoscopy for detection of renal calculi. Imaging modalities for detection of nephrolithiasis have centered on abdominal x-ray (KUB), ultrasound (US), and non-contrast computed tomography (CT). Sensitivities of 58-62% (KUB), 45% (US), and 95-100% (CT) have been previously reported. However, these results have never been correlated with endoscopic findings. METHODS: Idiopathic calcium oxalate stone formers with symptomatic calculi requiring ureteroscopy (URS) were studied...
April 3, 2018: Urology
https://www.readbyqxmd.com/read/29620409/is-the-education-available-to-anesthetists-adequate-to-provide-sedation-in-endoscopy-units
#6
Francisco Pérez Roldán
It is a letter that aims to emphasize the type of sedation that is sometimes used by anesthetists to perform a standard endoscopy and the excessive use of the operating room, which increases the cost of endoscopy and reduces the resources of surgical time.
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29614262/cost-effectiveness-analysis-comparing-lumen-apposing-metal-stents-with-plastic-stents-in-the-management-of-pancreatic-walled-off-necrosis
#7
Yen-I Chen, Alan N Barkun, Viviane Adam, Ge Bai, Vikesh K Singh, Majidah Bukhari, Olaya Brewer Gutierrez, B Joseph Elmunzer, Robert Moran, Lea Fayad, Mohamad El Zein, Vivek Kumbhari, Alessandro Repici, Mouen A Khashab
BACKGROUND AND AIMS: EUS-guided transmural drainage is effective in the management of pancreatic walled-off necrosis (WON). A lumen-apposing metal stent (LAMS) has recently been developed specifically for the drainage of pancreatic fluid collections showing promising results. However, no cost-effectiveness data have been published in comparison to endoscopic drainage with traditional plastic stents (PSs). The aim is to compare the cost-effectiveness of LAMSs to PSs in the management of WON...
March 31, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29607479/percutaneous-endoscopic-gastrostomy-in-ile-ife-nigeria-an-initial-report
#8
O I Alatise, M A Komolafe, E A Agbakwuru, A O Adisa, Y B Amusa
BACKGROUND: Protein-energy malnutrition is a common problem in critically ill patient and it is a major cause of accelerated morbidity and mortality in this group of patients. Recent dramatic advances in both enteral and parenteral nutritional support have ensured that most of these critically ill patients are adequately nutritionally supported. Unfortunately, most of these advancements in nutritional supports are far from the reach of most patients in developing countries. In this report, we highlighted the indications, success, challenges of the use of percutaneous endoscopic gastrostomy (PEG) in Nigeria patients...
January 2018: West African Journal of Medicine
https://www.readbyqxmd.com/read/29607431/evaluation-of-patients-with-gastric-polyps
#9
Sehmus Olmez, Suleyman Sayar, Bunyamin Saritas, Ayla Yildiz Savas, Ufuk Avcioglu, Ilyas Tenlik, Ersan Ozaslan, Hasan Tankut Koseoglu, Emin Altiparmak
OBJECTIVE: The incidence of gastric polyps (GPs) greatly differs according to study populations and was found to be 0.33%-6.7% in various studies. The majority of GPs are composed of hyperplastic polyps (HPs), fundic gland polyps (FGPs), and adenomatous polyps (APs). Although APs have a high risk of malignant potential, sporadic FGPs have no malignant potential. Conversely, HPs have a low risk of malignant potential. It is not sufficient to perform a biopsy to identify the polyp type and the presence of dysplasia; thus, some polyps may require multiple biopsies or total excision...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29606921/overview-of-current-concepts-in-gastric-intestinal-metaplasia-and-gastric-cancer
#10
David S Jencks, Jason D Adam, Marie L Borum, Joyce M Koh, Sindu Stephen, David B Doman
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The pathogenesis to gastric cancer is proposed by the Correa hypothesis as the transition from normal gastric epithelium to invasive cancer via inflammation followed by intramucosal cancer and invasion. Multiple risk factors have been associated with the development of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic factors, environmental milieu, rheumatologic disorders, diet, and intestinal microbiota...
February 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29601829/thirty-day-readmission-among-patients-with-non-variceal-upper-gastrointestinal-hemorrhage-and-effects-on-outcomes
#11
Marwan S Abougergi, Heather Peluso, John R Saltzan
BACKGROUND & AIMS: We aimed to determine the rate of hospital readmission within 30 days of non-variceal upper gastrointestinal hemorrhage (NVUGIH) and its impact on mortality, morbidity and healthcare utilization in the United States. METHODS: We performed a retrospective study using the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project Nationwide Readmission Database for the year 2014 (data on 14.9 million hospital stays at 2048 hospitals in 22 states)...
March 27, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29601652/comparison-of-clinical-outcomes-between-variceal-and-non-variceal-gastrointestinal-bleeding-in-patients-with-cirrhosis
#12
Parul Tandon, Kirles Bishay, Stacey Fisher, Dominique Yelle, Ian Carrigan, Krista Wooller, Erin Kelly
BACKGROUND AND AIM: Acute upper gastrointestinal bleeding (UGIB) in cirrhosis is associated with significant morbidity and mortality and can be classified as acute variceal bleeding (AVB) or non-variceal bleeding (NVB). Differences in mortality, hospital length of stay (LOS) and 30-day readmission have yet to be determined. As such, we aimed to evaluate differences in these clinical outcomes in cirrhotic patients admitted with UGIB. METHODS: This retrospective study included all cirrhotic patients hospitalized for UGIB who underwent upper endoscopy from July 2014 to July 2016...
March 30, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29578351/endoscopy-and-sedation-an-inseparable-binomial-for-the-gastroenterologist
#13
Javier Crespo, Álvaro Terán
The development of endoscopy and its increasing demand among the population have led to a growing need for propofol-based sedation techniques. Benefit is indisputable for both patients and endoscopists, but some aspects require considering the "who" and "how" of sedation as related to safety and health care costs. Propofol is first-choice in endoscopy for the European Society of Gastrointestinal Endoscopy because of its fast onset of action and short half-life, and many reports exist on its safety when used by gastroenterologists rather than anesthesiologists...
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29578350/severe-cardiorespiratory-complications-derived-from-propofol-sedation-monitored-by-an-endoscopist
#14
Sergio Maestro Antolín, Bruno Antonio Moreira Da Silva, Fernando Santos Santamarta, Arantza Germade, Laura Pérez Citores, Ana Santamaría, Rocío Bonoso Criado, Rosa Eva Madrigal, Esther Saracibar, Javier Barcenilla Laguna, Francisco Igea Arisqueta, Antonio Germán Pérez-Millán
INTRODUCTION: deep sedation with propofol monitored by an endoscopist in different endoscopy units is a controversial subject and the source of conflicts of interest between the various scientific societies of Anesthesiology and Gastroenterology. Many studies have already demonstrated the efficacy, efficiency and low incidence of complications associated with sedation when under the control of a trained endoscopist vs an anesthesiologist. MATERIAL AND METHODS: the rate of severe cardiorespiratory complications during various endoscopic examinations (gastroscopy, colonoscopy, endoscopic retrograde cholangiopancreatography [ERCP] and endoscopic ultrasound [EUS]) where sedation was controlled by an endoscopist within our unit, from 2011 to 2016, was reviewed...
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29574408/european-evidence-based-guidelines-on-pancreatic-cystic-neoplasms
#15
(no author information available yet)
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology)...
March 24, 2018: Gut
https://www.readbyqxmd.com/read/29569071/coloproctology-procedure-clinic-a-novel-service-developed-to-reduce-suffering-of-patients-with-bleeding-per-rectum
#16
Yasir Bashir, Bernadette McGovern, Mohammed Tahtouh, Tahir Abbasi, Maria Murphy, Paul Neary
AIMS: Evaluation of the role and impact of introducing a dedicated coloproctology procedure clinic in tertiary referral colorectal unit. METHODS: A retrospective analysis of 126 consecutive patients managed in the coloproctology clinic between March2015 and September 2016 was carried out. All patients were preselected for attendance based on symptom-based protocol. RESULTS: Based on the information available in GP referrals, 126 patients with bleeding per rectum with low risk of cancer were re-triaged from the general outpatient to dedicated coloproctology procedure clinic...
March 22, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29556753/the-use-of-drug-induced-sleep-endoscopy-in-england-and-belgium
#17
Vik Veer, Henry Zhang, Jolien Beyers, Olivier Vanderveken, Bhik Kotecha
PURPOSE: The purpose of this international survey is to ascertain the current practice of drug-induced sleep endoscopy (DISE) for patients with sleep-disordered breathing (SDB) by Otolaryngologists in the United Kingdom and Belgium. We compare the results with recommendations from the European Position Paper on drug-induced sleep endoscopy. METHODS: An online questionnaire was circulated to Consultant Otolaryngologists, independent practitioners, and trainees across the two countries...
March 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29549684/lipoma-of-the-transverse-colon-covered-by-tubulovillous-adenoma-a-rare-indication-for-surgical-treatment
#18
M Moschetta, R Virelli, F Laricchia, V Alberotanza, M Telegrafo, G Angelelli, A A Stabile Ianora
Lipomas of the digestive tract are rare benign tumours which, in most cases, are totally asymptomatic. Because of their localization within the intestinal wall, endoscopy may be completely negative so contrast-enhanced computed tomography (CT) is very important for detecting and typing these lesions. The case of a 49-year-old man with abdominal pain is presented. Colonoscopy and biopsy of a polypoid lesion on the right colonic flexure concluded for tubulovillous adenoma. The subsequent CT showed a polylobate lesion of 5 cm in diameter with predominant fat density causing luminal sub-stenosis...
January 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29535059/associations-of-microscopic-colitis-with-other-lymphocytic-disorders-of-the-gastrointestinal-tract
#19
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND & AIMS: Lymphocytic disorders of the upper and lower gastrointestinal tract seem to cluster in patients. We aimed to assess the frequency of comorbid occurrence of lymphocytic disorders in patients with microscopic colitis (MC). METHODS: We collected data from the Miraca Life Sciences Database, a large national electronic repository of histopathologic records of patients throughout the United States. In a population of 228,506 patients who underwent bidirectional endoscopy from January 2008 through July 2016, we studied the comorbid occurrence of celiac disease, duodenal intraepithelial lymphocytosis, lymphocytic gastritis, and lymphocytic esophagitis among 3456 patients with MC...
March 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29531465/quality-indicators-in-pediatric-colonoscopy-in-a-low-volume-center-implications-for-training
#20
Way-Seah Lee, Chun-Wei Tee, Zhong-Lin Koay, Tat-Seng Wong, Fatimah Zahraq, Hee-Wei Foo, Sik-Yong Ong, Shin-Yee Wong, Ruey-Terng Ng
AIM: To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training center. METHODS: We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years (January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as benchmarks...
March 7, 2018: World Journal of Gastroenterology: WJG
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