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https://www.readbyqxmd.com/read/29040226/propranolol-and-oxandrolone-therapy-accelerated-muscle-recovery-in-burned-children
#1
Tony Chao, Craig Porter, David N Herndon, Aikaterina Siopi, Henry Ideker, Ronald P Mlcak, Labros S Sidossis, Oscar E Suman
INTRODUCTION: Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogues showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness and protein turnover are unknown...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28920065/the-influence-of-sex-steroid-hormones-on-the-response-to-trauma-and-burn-injury
#2
REVIEW
K Al-Tarrah, N Moiemen, J M Lord
Trauma and related sequelae result in disturbance of homeostatic mechanisms frequently leading to cellular dysfunction and ultimately organ and system failure. Regardless of the type and severity of injury, gender dimorphism in outcomes following trauma have been reported, with females having lower mortality than males, suggesting that sex steroid hormones (SSH) play an important role in the response of body systems to trauma. In addition, several clinical and experimental studies have demonstrated the effects of SSH on the clinical course and outcomes following injury...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28648787/online-turbulent-flow-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry-for-high-throughput-screening-of-anabolic-steroids-in-horse-urine
#3
Hyun Du Shin, Joon Hyuk Suh, Junghyun Kim, Hyun-Deok Cho, Su Duk Lee, Kwan Seok Han, Yu Wang, Sang Beom Han
A high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine by online turbulent flow extraction coupled with liquid chromatography-tandem mass spectrometry was developed. The use of turbulent flow chromatography could simplify pretreatment of horse urine, which has complex matrices as well as high viscosity...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28631809/anabolic-steroids-for-treating-pressure-ulcers
#4
REVIEW
Cho Naing, Maxine A Whittaker
BACKGROUND: Pressure ulcers, also known as bed sores, pressure sores or decubitus ulcers develop as a result of a localised injury to the skin or underlying tissue, or both. The ulcers usually arise over a bony prominence, and are recognised as a common medical problem affecting people confined to a bed or wheelchair for long periods of time. Anabolic steroids are used as off-label drugs (drugs which are used without regulatory approval) and have been used as adjuvants to usual treatment with dressings, debridement, nutritional supplements, systemic antibiotics and antiseptics, which are considered to be supportive in healing of pressure ulcers...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28557789/stability-of-alprazolam-atropine-sulfate-glutamine-levofloxacin-metoprolol-tartrate-nitrofurantoin-ondansetron-hydrochloride-oxandrolone-pregabaline-and-riboflavin-in-syrspend-sf-ph4-oral-suspensions
#5
Anderson O Ferreira, Hudson C Polonini, Sharlene Loures da Silva, Victor Augusto Cerqueira de Melo, Laura de Andrade, Marcos Antônio Fernandes Brandão
The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients compounded in oral suspensions using an internationally used suspending vehicle (SyrSpend SF PH4): alprazolam 1.0 mg/mL, atropine sulfate 0.1 mg/mL, glutamine 250.0 mg/mL, levofloxacin 50.0 mg/mL, metoprolol tartrate 10.0 mg/mL, nitrofurantoin 2.0 mg/mL, ondansetron hydrochloride 0.8 mg/mL, oxandrolone 3.0 mg/mL, pregabaline 20.0 mg/mL, riboflavin 10.0 mg/mL. All suspensions were stored at both controlled refrigeration (2°C to 8°C) and controlled room temperature (20°C to 25°C)...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28285751/androgen-treatment-effects-on-motor-function-cognition-and-behavior-in-boys-with-klinefelter-syndrome
#6
RANDOMIZED CONTROLLED TRIAL
Judith L Ross, Harvey Kushner, Karen Kowal, Martha Bardsley, Shanlee Davis, Allan L Reiss, Nicole Tartaglia, David Roeltgen
OBJECTIVES: To examine the effects of early low-dose androgen on motor, cognitive, and behavioral function in prepubertal boys with Klinefelter syndrome (47,XXY). STUDY DESIGN: Double-blind trial of 84 boys, ages 4-12 years, randomized to oxandrolone (Ox; 0.06?mg/kg daily; n?=?43) or placebo (Pl; n?=?41) for 24 months. Standardized assessments were performed at baseline and every 12 months for 24 months evaluating motor, cognitive, and behavioral function. RESULTS: The 24-month outcomes were better in the Ox vs...
June 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28240622/oxandrolone-coadministration-does-not-alter-plasma-propranolol-concentrations-in-severely-burned-pediatric-patients
#7
Ashley N Guillory, David N Herndon, Michael B Silva, Clark R Andersen, Oscar E Suman, Celeste C Finnerty
The systemic impact of severe burn injury results in a variety of disorders that require therapeutic intervention. Propranolol, a nonselective β1, β2-adrenergic receptor antagonist, reduces resting heart rate and cardiac work caused by elevated circulating catecholamines. Oxandrolone, a testosterone mimetic, promotes protein synthesis and anabolism to counter muscle wasting. Coadministration of these drugs is expected to synergistically improve patient outcomes. Testosterone administration is known to alter β-adrenergic receptor-mediated signaling...
July 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28166447/nutrition-support-for-persistent-inflammation-immunosuppression-and-catabolism-syndrome
#8
Frederick A Moore, Stuart M Phillips, Craig J McClain, Jayshil J Patel, Robert G Martindale
Despite tremendous advances in critical care, multiple-organ failure continues to be a significant problem. However, in recent years, far fewer patients with multiple-organ failure die early, but many experience ongoing immune dysregulation and are developing persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Most PICS patients are discharged to nonhome destinations, fail to rehabilitate, and succumb to indolent death. From a nutrition perspective, patients with PICS experience persistent inflammation-induced cachexia despite evidenced-based recommended intensive care unit nutrition support...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28002075/what-factors-influence-protein-synthesis-and-degradation-in-critical-illness
#9
Filippo G Di Girolamo, Roberta Situlin, Gianni Biolo
PURPOSE OF REVIEW: The optimal approach to improve protein metabolism in critical illness is not yet fully defined. Here, we have summarized recent literature dealing with the main catabolic and anabolic factors influencing protein kinetics in acute hypercatabolic patients. RECENT FINDINGS: Protein/amino acid intake levels should be adapted to type and severity of illness, keeping in mind that energy overfeeding is associated with poor outcome. A number of anticatabolic nutraceuticals and drugs have been tested in acute patients...
March 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27802097/effects-of-oxandrolone-on-cardiometabolic-health-in-boys-with-klinefelter-syndrome-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Shanlee M Davis, Matthew G Cox-Martin, Martha Z Bardsley, Karen Kowal, Philip S Zeitler, Judith L Ross
Context: Klinefelter syndrome (KS) is a common condition in males, resulting in androgen deficiency and cardiometabolic diseases. These interrelated conditions may be present in prepubertal boys with KS. Objective: To determine whether supplemental low-dose androgen has a beneficial effect on body composition in prepubertal boys with KS. Design, Setting, and Participants: We conducted a secondary analysis of a randomized, double-blind, placebo-controlled clinical trial in 93 boys with KS aged 4 to 12 years...
January 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27673331/a-novel-drug-mouse-phenotypic-similarity-method-detects-molecular-determinants-of-drug-effects
#11
Jeanette Prinz, Ingo Vogt, Gianluca Adornetto, Mónica Campillos
The molecular mechanisms that translate drug treatment into beneficial and unwanted effects are largely unknown. We present here a novel approach to detect gene-drug and gene-side effect associations based on the phenotypic similarity of drugs and single gene perturbations in mice that account for the polypharmacological property of drugs. We scored the phenotypic similarity of human side effect profiles of 1,667 small molecules and biologicals to profiles of phenotypic traits of 5,384 mouse genes. The benchmarking with known relationships revealed a strong enrichment of physical and indirect drug-target connections, causative drug target-side effect links as well as gene-drug links involved in pharmacogenetic associations among phenotypically similar gene-drug pairs...
September 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27535042/novel-uses-for-the-anabolic-androgenic-steroids-nandrolone-and-oxandrolone-in-the-management-of-male-health
#12
REVIEW
Christopher Wu, Jason R Kovac
There has recently been renewed interest in novel clinical applications of the anabolic-androgenic steroid (AAS) testosterone and its synthetic derivatives, particularly given with the rising popularity of testosterone supplementation therapy (TST) for the treatment of male hypogonadism. In this manuscript, we provide a brief review of the history of AAS and discuss clinical applications of two of the more well-known AAS: nandrolone and oxandrolone. Both agents exhibit favorable myotrophic/androgenic ratios and have been investigated for effectiveness in numerous disease states...
October 2016: Current Urology Reports
https://www.readbyqxmd.com/read/27433905/reversal-of-growth-arrest-with-the-combined-administration-of-oxandrolone-and-propranolol-in-severely-burned-children
#13
RANDOMIZED CONTROLLED TRIAL
David N Herndon, Charles D Voigt, Karel D Capek, Paul Wurzer, Ashley Guillory, Andrea Kline, Clark R Andersen, Gordon L Klein, Ronald G Tompkins, Oscar E Suman, Celeste C Finnerty, Walter J Meyer, Linda E Sousse
BACKGROUND: The hypercatabolic response in severely burned pediatric patients is associated with increased production of catecholamines and corticosteroids, decreased formation of testosterone, and reduced strength alongside growth arrest for up to 2 years after injury. We have previously shown that, in the pediatric burned population, the administration of the testosterone analog oxandrolone improves lean body mass accretion and bone mineral content and that the administration of the β1-, β2-adrenoceptor antagonist propranolol decreases cardiac work and resting energy expenditure while increasing peripheral lean mass...
September 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27394004/analysis-of-sulfate-metabolites-of-the-doping-agents-oxandrolone-and-danazol-using-high-performance-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#14
S Rzeppa, L Viet
The direct detection of sulfate conjugates of anabolic androgenic steroids (AAS) can be a powerful tool in doping control analysis. By skipping the solvolysis step analysis time can be reduced, and due to long term sulfate metabolites the detection time can be significantly extended as demonstrated for some AAS. This study presents the successful identification of sulfate metabolites of the doping agents oxandrolone and danazol in excretion urines by high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS)...
September 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27314258/nutrition-in-burn-injury-any-recent-changes
#15
Mette M Berger, Olivier Pantet
PURPOSE OF REVIEW: After major progress in the 1980s of burn resuscitation resulting, the last years' research has focused on modulation of metabolic response and optimization of substrate utilization. The persisting variability of clinical practice is confirmed and results in difficult comparisons between burn centers. RECENT FINDINGS: Recent research explores intracellular mechanisms of the massive metabolic turmoil observed after burns: very early alterations at the mitochondrial level largely explain the hypermetabolic response, with a diminished coupling of oxygen consumption and ATP production...
August 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27272101/anabolic-and-anticatabolic-agents-in-critical-care
#16
Mile Stanojcic, Celeste C Finnerty, Marc G Jeschke
PURPOSE OF REVIEW: A complex network of hormones and other effectors characterize the hypermetabolic response in critical illness; these mediators work together to induce numerous pathophysiologic alterations. Increased incidence of infection, multiorgan failure, long-term debilitation, delays in rehabilitation, and death result from an inability to meet the prohibitively elevated protein and energy requirements, which occur during illness and can persist for several years. Pharmacologic interventions have been successfully utilized to attenuate particular aspects of the hypermetabolic response; these modalities are a component of managing critically ill patients - including those patients with severe burns...
August 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27257953/use-of-oxandrolone-to-promote-growth-in-neonates-following-surgery-for-complex-congenital-heart-disease-an-open-label-pilot-trial
#17
COMPARATIVE STUDY
Phillip T Burch, Michael G Spigarelli, Linda M Lambert, Patrick D Loftus, Catherine M Sherwin, Matthew W Linakis, Xiaoming Sheng, L LuAnn Minich, Richard V Williams
OBJECTIVE: Malnutrition and poor weight gain, common in neonates following repair of complex congenital heart disease (CHD), are associated with increased morbidity and mortality. Oxandrolone, an anabolic steroid, improves weight gain in older children at high-risk for growth failure. We sought to determine feasibility, safety, and efficacy of oxandrolone therapy in neonates following surgery for complex CHD. DESIGN: Neonates with RACHS-1 score >3 were eligible to receive open-label oxandrolone for 28 days in this prospective pilot trial...
December 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27252608/progress-in-burns-research-a-review-of-advances-in-burn-pathophysiology
#18
P I Jewo, I O Fadeyibi
Severe burns trigger a wide range of responses in the victim. Initial vascular changes are followed by hypermetabolic, inflammatory and immunologic changes. The prolonged hypermetabolic response is associated with an elevated resting rate of energy consumption, tissue wasting and altered substrate kinetics. There is increased blood glucose though insulin levels are above normal. The cortisol level is raised and, together with catecholamine, drives the metabolic response. The immune system is typically weakened...
June 30, 2015: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27171844/long-term-administration-of-oxandrolone-improves-lung-function-in-pediatric-burned-patients
#19
Linda E Sousse, David N Herndon, Ronald P Mlcak, Jong O Lee, Clark R Andersen, Andrew J Zovath, Celeste C Finnerty, Oscar E Suman
Pulmonary dysfunction is a significant contributor to morbidity and mortality in the pediatric burned population. We have previously reported that the administration of a synthetic testosterone derivative, oxandrolone, significantly reduced hypermetabolism, and significantly increased height percentile, bone mineral content, lean body mass, and strength in pediatric burned patients. We hypothesize that the administration of oxandrolone will improve pulmonary function in burned pediatric subjects. A subset of severely burned pediatric subjects from a prospective clinical trial (n = 222) were included in our study (n = 54, 7-18 years, ≥30% TBSA burn)...
September 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27138297/transdermal-oxandrolone-ex-vivo-percutaneous-absorption-study
#20
Hudson Polonini, Anderson de Oliveira Ferreira, Nádia Rezende Barbosa Raposo, Marcos Antônio Fernandes Brandão
The objective of this study was to evaluate the permeability of oxandrolone in human skin on a preliminary basis for possible future determination of the transdermal route as an alternative to oral treatments. For this purpose, we used a percutaneous absorption assay in Franz diffusion cells coupled with freshly excised human skin. The drug release kinetics were determined to predict the efficiency of this alternative route for the drug. Nearly 236 µg (86.7%, in terms of applied dose) of the product was prevented to permeate due to the barrier function of the stratum corneum (SC); 21...
May 2, 2016: Current Drug Delivery
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