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hypertrophic myocardiopathy with low ejection fraction

P Cosnay, J P Fauchier, M Lang, D Casset, P Raynaud, G Lavigne, R Itti
In a randomized, double-blind, cross-over study with plasma drug assays, 16 patients (11 men, 5 women; mean age 48.56 +/- 3.61 years) presenting with hypertrophic obstructive cardiomyopathy confirmed by echocardiography, left ventriculography and left intraventricular gradient measurement were treated with verapamil 480 mg/day or propranolol 320 mg/day. Both treatments produced functional improvement (p less than 0.01) which was more distinct with verapamil (NS). No changes in cardiothoracic index, echocardiographic parameters and Sokolow's index were observed...
March 1987: Archives des Maladies du Coeur et des Vaisseaux
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