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https://www.readbyqxmd.com/read/29334631/acceptability-of-intervention-materials-to-decrease-risk-for-alcohol-and-medication-interactions-among-older-adults
#1
Faika Zanjani, Hannah Allen, Nancy Schoenberg, Catherine Martin, Richard Clayton
BACKGROUND: The majority of older adults take prescription or over-the-counter medications and about half consume alcohol regularly. Despite high risk for alcohol medication interactions (AMI), few community-level interventions exist to prevent AMI. The current study assessed the acceptability of educational materials created for use in a brief intervention to prevent AMI among older adults. METHODS: Older adults from two senior centers reviewed intervention materials (poster, patient and pharmacist brochures, and public service announcement) and participated in a pre and post-test to provide feedback and to assess changes in AMI-related awareness and intentions...
December 24, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29334532/cost-effectiveness-and-improved-parent-and-provider-satisfaction-with-outpatient-management-of-pediatric-oncology-patients-with-low-risk-fever-and-neutropenia
#2
Abhishek Bavle, Amanda Grimes, Sibo Zhao, Daniel Zinn, Andrea Jackson, Binita Patel, Timothy Porea, Ankhi Dutta, Heidi Russell, Andras Heczey
On the basis of significant evidence for safety, the international pediatric fever and neutropenia committee recommends the identification and management of patients with "low-risk fever and neutropenia" (LRFN), outpatient with oral antibiotics, instead of traditional inpatient management. The aim of our study was to compare the cost-per-patient with these 2 strategies, and to evaluate parent and provider satisfaction with the outpatient management of LRFN. Between March 2016 and February 2017, 17 LRFN patients (median absolute neutrophil count, 90/μL) were managed at a single institution, per new guidelines...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29334528/comparison-of-laparoscopic-and-open-pancreaticoduodenectomy-for-the-treatment-of-nonpancreatic-periampullary-adenocarcinomas
#3
Ling-Wei Meng, Yun-Qiang Cai, Yong-Bin Li, He Cai, Bing Peng
BACKGROUND: Laparoscopic pancreaticoduodenectomy (LPD), a surgical option for nonpancreatic periampullary adenocarcinoma (NPPA), is a complex procedure that has become increasing popular. However, there is no consensus as to whether this technique should be performed routinely. Our aim was to evaluate the outcomes of LPD compared with open pancreaticoduodenectomy (OPD). MATERIALS AND METHODS: From October 2010 to September 2015, 58 LPDs were performed to treat NPPA and were compared with 58 OPDs, which can theoretically be carried out by laparoscopic approach...
January 12, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29334495/the-ethics-of-interventional-procedures-for-patients-too-ill-for-surgery
#4
Caroline G Kan, Michael Nurok
PURPOSE OF REVIEW: Minimally invasive interventional procedures are increasingly popular options for patients who are high-risk candidates for open surgical procedures. It is unclear how to proceed in the rare circumstance of a complication during an interventional procedure, where addressing the complication would require exposing the patient to the full risk that was being avoided with the minimally invasive technique. This review provides recommendations on how to approach this paradoxical scenario...
January 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29334480/strategies-for-enhancing-medical-student-resilience-student-and-faculty-member-perspectives
#5
Julia Farquhar, Robert Kamei, Arpana Vidyarthi
Objectives: To improve programs aimed to enhance medical student resiliency, we examined both medical student and faculty advisor perspectives on resiliency-building in an Asian medical school. Methods: In two separate focus groups, a convenience sample of 8 MD-PhD students and 8 faculty advisors were asked to identify strategies for enhancing resilience. Using thematic analysis, two researchers independently examined discussion transcripts and field notes and determined themes through a consensus process...
January 12, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29334434/the-case-for-stabilized-stannous-fluoride-dentifrice-an-advanced-formulation-designed-for-patient-preference
#6
Tao He, Svetlana Farrell
Oral diseases, particularly caries and gingivitis, continue to be widespread. Incorporating a stabilized stannous fluoride dentifrice into patients' daily oral hygiene routine is a convenient, cost effective approach to improve and protect their oral health and the appearance of their smile. Unlike other common fluorides that only provide anti-caries benefits (e.g., sodium fluoride and sodium monofluorophosphate), stabilized stannous fluoride formulations have demonstrated broader and significantly greater protection, also reducing plaque, gingivitis, erosion, sensitivity, and halitosis...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334415/early-burst-in-body-size-evolution-is-uncoupled-from-species-diversification-in-diving-beetles-dytiscidae
#7
Aurélie Désamoré, Benjamin Laenen, Kelly B Miller, Johannes Bergsten
Changes in morphology are often thought to be linked to changes in species diversification, which is expected to leave a signal of Early Burst (EB) in phenotypic traits. However, such signal is rarely recovered in empirical phylogenies, even for groups with well-known adaptive radiation. Using a comprehensive phylogenetic approach in Dytiscidae, which harbors ~4,300 species with as much as 50-fold variation in body size among them, we ask whether pattern of species diversification correlates with morphological evolution...
January 15, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29334412/stallion-semen-quality-depends-on-mhc-matching-to-teaser-mare
#8
E Jeannerat, E Marti, C Berney, F Janett, H Bollwein, H Sieme, D Burger, C Wedekind
The major histocompatibility complex (MHC) has repeatedly been found to influence mate choice of vertebrates, with MHC-dissimilar mates typically being preferred over MHC-similar mates. We used horses (Equus caballus) to test whether MHC matching also affects male investment into ejaculates after short exposure to a female. Semen characteristics varied much among stallions. Controlling for this variance with a full-factorial within-subject experimental design, we found that a short exposure to an MHC-dissimilar mare enhanced male plasma testosterone and led to ejaculates with elevated sperm numbers as compared to exposure to an MHC-similar mare...
January 15, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29334194/enrollment-in-early-phase-clinical-trials-in-pediatric-oncology-the-experience-at-institut-curie
#9
Aurore Surun, Marie-Églantine Dujaric, Isabelle Aerts, Daniel Orbach, Irène Jiménez, Hélène Pacquement, Gudrun Schleiermacher, Franck Bourdeaut, Jean Michon, Jean-Claude K Dupont, François Doz
BACKGROUND: The European Paediatric Regulation was introduced in 2007 to facilitate access to new medicines for children. Our study explored accessibility of early-phase trials in pediatric oncology, in line with the European Paediatric Regulation, to identify the reasons for not inviting patients to participate, parents' refusal, or inclusion failure. PROCEDURE: We conducted a retrospective chart review at Institut Curie, Paris, for all pediatric patients whose cancer progressed despite known effective treatments between July 2010 and December 2013...
January 15, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29334171/dft-studies-on-the-reaction-mechanism-for-direct-cyclization-of-linear-c5-c6-and-c7-alkenes-over-h-itq-13-zeolite
#10
Hong Ma, Yanyan Chen, Zhihong Wei, Sen Wang, Zhangfeng Qin, Mei Dong, Junfen Li, Jianguo Wang, Weibin Fan
Although dienes or trienes have been shown to be possible precursors for cyclization, direct cyclization of alkenes or alkoxides has not been systematically studied yet. Thus, the reaction mechanism of cyclization of linear alkenes was investigated here with H-ITQ-13 by density functional theory considering dispersive interactions (DFT-D). The similar free energy of different linear alkoxides of the same carbon number suggests that they can co-exist in the H-ITQ-13 intersection at 673.15 K during MTO process...
January 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29333898/the-physical-health-of-individuals-receiving-antipsychotic-medication-a-qualitative-inquiry-on-experiences-and-needs
#11
Angela M Cocoman, Mary Casey
Individuals with a mental illness are reported to have a reduced life expectancy and a greater risk of being affected by preventable physical illnesses such as cardiovascular disease and Type 2 diabetes. This inquiry sought to identify the physical health beliefs, experiences and needs of individuals with mental health problems in receipt of antipsychotic medication who live in the community. A qualitative inquiry was undertaken using three focus groups in a community mental health service in Ireland with 21 participants with mental health problems who were treated with antipsychotic medication...
January 15, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29333632/binding-of-cu-and-cu2-with-peptides-peptides-oxytocin-arg8-vasopressin-bradykinin-angiotensin-i-substance-p-somatostatin-and-neurotensin
#12
Thankan Jayasekharan, Shyam L Gupta, Vikas Dhiman
The intrinsic binding ability of seven natural peptides (oxytocin, arg8 -vasopressin, bradykinin, angiotensin-I, substance-P, somatostatin, and neurotensin) with copper in two different oxidation states (CuI/II ) derived from different Cu+/2+ precursor sources have been investigated for their charge dependent binding characteristics. The peptide-CuI/II complexes, [M - (n-1)H + nCuI ] and [M - (2n-1)H + nCuII ] are prepared/generated by the reaction of peptides with CuI solution/Cu-target and CuSO4 solution, and are analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS)...
January 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29333602/children-s-perceptions-of-economic-groups-in-a-context-of-limited-access-to-opportunities
#13
Laura Elenbaas, Melanie Killen
Children (N = 267, ages 8-14 years, M = 11.61 years, middle to upper-middle income) made predictions regarding groups of same-aged peers from high-wealth and low-wealth backgrounds. The context involved granting access to a special opportunity. From middle childhood to early adolescence children increasingly expected both high- and low-wealth groups to want access to opportunities for their own group. However, children viewed high-wealth groups as motivated in part by selfishness and low-wealth groups as concerned in part with broader economic inequality...
January 15, 2018: Child Development
https://www.readbyqxmd.com/read/29333569/an-integrated-fuzzy-based-advanced-eutrophication-simulation-model-to-develop-the-best-management-scenarios-for-a-river-basin
#14
Rallapalli Srinivas, Ajit Pratap Singh
Assessment of water quality status of a river with respect to its discharge has become prerequisite to sustainable river basin management. The present paper develops an integrated model for simulating and evaluating strategies for water quality management in a river basin management by controlling point source pollutant loadings and operations of multi-purpose projects. Water Quality Analysis and Simulation Program (WASP version 8.0) has been used for modeling the transport of pollutant loadings and their impact on water quality in the river...
January 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29333531/patient-reported-outcome-measures-prom-as-a-preoperative-assessment-tool
#15
Sunghye Kim, Pamela W Duncan, Leanne Groban, Hannah Segal, Rica Moonyeen Abbott, Jeff D Williamson
Aim of review: Patient-reported outcomes (PRO) on functional, social, and behavioral factors might be important preoperative predictors of postoperative outcomes. We conducted a literature review to explore associations of preoperative depression, socioeconomic status, social support, functional status/frailty, cognitive status, self-management skills, health literacy, and nutritional status with surgical outcomes. Methods: Two electronic data bases, including PubMed and Google Scholar, were searched linking either depression, socioeconomic status, social support, functional status/frailty, cognitive status, self-management skills, health literacy, or nutritional status with surgery, postoperative complications, or perioperative period within the past 2 decades...
November 28, 2017: Journal of Anesthesia and Perioperative Medicine
https://www.readbyqxmd.com/read/29333392/enhancing-sensory-perception-of-plant-based-nutraceutical-drinks-by-combining-plants-from-different-sources-a-preliminary-study-of-tea-and-ginger-blend
#16
Solomon Akinremi Makanjuola, Victor Ndigwe Enujiugha
Tea-ginger drink was selected for evaluation due to its nutraceutical potential. Panelists rated preference for drinks prepared from tea, ginger, and tea+ginger powder for colour, taste, and aroma. The obtained data were evaluated using analysis of variance, principal component analysis, and agglomerative hierarchical clustering. Also the colour preference scores were evaluated against instrumental colour measurements. The ginger drink had lower rating for colour preference and the tea drink had lower ratings for aroma and taste preference...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333356/metachronous-testicular-cancer-after-orchiectomy-a-rare-case
#17
Ersan Arda, Basri Cakiroglu, Gizem Cetin, Ilkan Yuksel
Testicular cancer represents approximately 1% of all cancers diagnosed in males. The prevalence of bilateral testicular germ cell tumor cases varies from 1% to 5%. Intratubular germ cell neoplasia (ITGCN) is a precursor for almost all testicular germ cell tumors (TGCT) and is one of the highest risks of developing contralateral testicular cancer. The radical orchiectomy is still preferred for the treatment of testicular cancer. However, in some cases like solitary testis, bilateral cancer or if the tumor size is under 30% percent of the testicular extent, organ-sparing surgery can be an option...
November 9, 2017: Curēus
https://www.readbyqxmd.com/read/29333343/resounding-failure-to-replicate-links-between-developmental-language-disorder-and-cerebral-lateralisation
#18
Alexander C Wilson, Dorothy V M Bishop
Background: It has been suggested that failure to establish cerebral lateralisation may be related to developmental language disorder (DLD). There has been weak support for any link with handedness, but more consistent reports of associations with functional brain lateralisation for language. The consistency of lateralisation across different functions may also be important. We aimed to replicate previous findings of an association between DLD and reduced laterality on a quantitative measure of hand preference (reaching across the midline) and on language laterality assessed using functional transcranial Doppler ultrasound (fTCD)...
2018: PeerJ
https://www.readbyqxmd.com/read/29333105/measures-and-metrics-for-feasibility-of-proof-of-concept-studies-with-human-immunodeficiency-virus-rapid-point-of-care-technologies-the-evidence-and-the-framework
#19
REVIEW
Nitika Pant Pai, Tiago Chiavegatti, Rohit Vijh, Nicolaos Karatzas, Jana Daher, Megan Smallwood, Tom Wong, Nora Engel
Objective: Pilot (feasibility) studies form a vast majority of diagnostic studies with point-of-care technologies but often lack use of clear measures/metrics and a consistent framework for reporting and evaluation. To fill this gap, we systematically reviewed data to (a) catalog feasibility measures/metrics and (b) propose a framework. Methods: For the period January 2000 to March 2014, 2 reviewers searched 4 databases (MEDLINE, EMBASE, CINAHL, Scopus), retrieved 1441 citations, and abstracted data from 81 studies...
December 2017: Point of Care
https://www.readbyqxmd.com/read/29333042/gas-chromatography-mass-spectrometry-profiling-in-methanolic-and-ethyl-acetate-root-and-stem-extract-of-corbichonia-decumbens-forssk-exell-from-thar-desert-of-rajasthan-india
#20
Sunita Arora, Manju Saini
Background: Corbichonia decumbens (Forssk.) Exell (Molluginaceae), recently has moved to Lophiocarpaceae as per angiospermic plant group (APG) III system, is an annual or short-lived, dwarf, glabrous subshrub, prefers to grow on rocky places and on sand-stones in dry, hot areas of Rajasthan. This is the potential plant with medicinal properties. Vegetative organs under study show antioxidant, anti-inflammatory, antiulcer, antimicrobial, and antinociception activity. Objective: This study was carried out to identify the phytoconstituents present in the methanolic and ethyl-acetate extract of root and stem of C...
December 2017: Pharmacognosy Research
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