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Rhabdomyosarcoma

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https://www.readbyqxmd.com/read/29237964/myeloid-sarcoma-a-clinicopathological-study-with-emphasis-on-diagnostic-difficulties
#1
Ranjini Kudva, Vidya Monappa, Girish Solanke, Manna Valiathan, Anuradha C K Rao, V Geetha
BACKGROUND: Myeloid sarcoma (MS) is a rare tumor composed of proliferation of myeloid precursors at extramedullary sites. They can arise de-novo or in association with hematological malignancies, most commonly acute myeloid leukemia. Clinically, it can masquerade as an abscess, cutaneous ulcer, or mass lesion. Morphologically, MS can mimic a variety of small round cell tumors including lymphomas and rhabdomyosarcoma. AIMS: (1) To study the clinical presentations and laboratory findings in patients with MS; (2) to revisit the histomorphological findings and the differential diagnosis of MS; (3) to evaluate the diagnostic role of immunohistochemistry (IHC) and determine the useful markers for accurate diagnosis of MS...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237527/-a-rhabdomyosarcoma-patient-from-a-li-fraumeni-syndrome-family-a-case-report-and-literature-review
#2
Yao Xie, Wei-Hong Zhao, Ying Hua, Qing Sun, Peng-Hui Wu
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome, with the characteristics of early onset of cancer and high cancer incidence. TP53 is widely accepted as a pathogenic gene of LFS. A 2 years and 6 months old boy is reported in this article, who was diagnosed with embryonal rhabdomyosarcoma (RMS) in the left submandibular region. His brother died of RMS, and his grandmother was diagnosed with breast cancer. TP53 gene mutation detection was performed in this patient and some family members, indicating a missense mutation in exon 8 of the patient: c...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29233732/foley-catheter-as-vaginal-stent-in-a-toddler-with-vaginal-rhabdomyosarcoma
#3
Kylie G Fowler, Pranshu Mohindra, Aerang Kim, Veronica Gomez-Lobo
No abstract text is available yet for this article.
December 9, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29230040/congenital-embryonal-rhabdomyosarcoma-caused-by-heterozygous-concomitant-ptch1-and-ptch2-germline-mutations
#4
Julia Taeubner, Triantafyllia Brozou, Nan Qin, Jasmin Bartl, Sebastian Ginzel, Joerg Schaper, Joerg Felsberg, Simone Fulda, Christian Vokuhl, Arndt Borkhardt, Michaela Kuhlen
The sonic hedgehog (SHH) signaling pathway has been shown to play important roles in embryogenesis, cell proliferation as well as in cell differentiation. It is aberrantly activated in various common cancers in adults, but also in pediatric neoplasms, such as rhabdomyosarcoma (RMS) and atypical teratoid/rhabdoid tumors (AT/RTs). Dysregulation and germline mutation in PATCHED1 (PTCH1), a receptor for SHH, is responsible for the Gorlin Syndrome, a familial cancer predisposing syndrome including RMS. Here, we report a newborn diagnosed with congenital embryonal RMS...
December 11, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29226038/pencil-beam-scanning-proton-therapy-for-rhabdomyosarcoma-of-the-biliary-tract
#5
Luke Pater, Brian Turpin, Anthony Mascia
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with 250-350 cases diagnosed annually in the United States. Biliary tract rhabdomyosarcoma is rare, representing <1% of the RMS cases. Due to its location, resection is clinically challenging, and functional complications exist and persist from biliary obstruction. The anatomical location of this tumor presents both opportunities and challenges for pencil beam scanning proton therapy. Proton therapy offers a dosimetric and clinical advantage by sparing the healthy liver, stomach, contra-lateral kidney and bowel...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29224022/bladder-fetal-rhabdomyoma-intermediate-type
#6
L González-Pérez, H Alvarez-Argüelles, V J Ramos Gutiérrez, S García Hernández, A C Plata Bello, T Concepción Masip, E Salido Ruiz
INTRODUCTION: Rhabdomyomas are benign tumors of striated muscle, the bladder localization is very rare. CLINICAL CASE: We present an 87-year-old male consulting for gross hematuria. Cystoscopy was done with evidence of bulged bladder mucosa in right side wall and dome. Post-transurethral resection of the bladder (TURB) pathological anatomy was negative for malignancy. As extension study abdominopelvic computed tomography was performed identifying a bladder thickening of right posterior sidewall and an increased density of the adjacent fat...
December 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29223737/synthesis-and-characterization-of-small-sized-gold-nanoparticles-coated-by-bovine-serum-albumin-bsa-for-cancer-photothermal-therapy
#7
Selma M H Al-Jawad, Ali A Taha, Mohammad M F Al-Habosiy, Lamyaa F A Al-Barram
In the present study, small gold nanoparticles <5nm coated with natural protein Bovine Serum Albumin (BSA) was synthesized and characterized using UV-Vis spectrophotometer, Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM), zeta potential and scanning electron microscopy (SEM). Three types of cancer cell lines; Rhabdomyosarcoma (RD), Murine fibroblast (L20B) and RAW 264.7 monocyte-macrophage (MQ) were tested and treated by photothermal strategy, in vitro, by conjugating BSA-AuNPs complex of (0...
December 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29220292/rhabdomyosarcoma-ewing-sarcoma-and-other-round-cell-sarcomas
#8
Alberto S Pappo, Uta Dirksen
Several recent advances have been made in the diagnosis and therapy of malignant small round cell tumors that affect children, particularly in rhabdomyosarcoma, Ewing sarcoma, and other round cell sarcomas. These advances have provided new insights into the pathologic, histologic, and genomic characterization of specific tumor subtypes, which has led to the identification of novel therapeutic targets and improved stratification of risk. This has, in turn, led to improved efficacy in clinical trials of new drug combinations, thereby increasing the survival of patients with newly diagnosed and refractory or recurrent round cell sarcomas...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29217286/pediatric-protocol-of-multimodal-therapy-is-associated-with-improved-survival-in-ayas-and-adults-with-rhabdomyosarcoma
#9
Trevan D Fischer, Shrawan G Gaitonde, Bradley C Bandera, Mehul V Raval, Sanjeev A Vasudevan, Kenneth W Gow, Elizabeth A Beierle, John J Doski, Adam B Goldin, Monica Langer, Jed G Nuchtern, Stacey Stern, Leland J Foshag, Melanie Goldfarb
BACKGROUND: Multimodal therapy is the standard treatment for pediatric rhabdomyosarcoma, but for adolescents and young adults (AYAs: ages 15-39) and older adults with rhabdomyosarcoma, the use of adjuvant therapy is variable, and survival is greatly decreased compared with younger patients. METHODS: All patients with rhabdomyosarcoma who had a curative operative were identified from the 1998-2012 National Cancer Database. Regression analyses identified independent factors relating to receipt of multimodal therapy (resection + chemotherapy + radiation) and the influence of multimodal therapy on 5-year overall survival...
December 4, 2017: Surgery
https://www.readbyqxmd.com/read/29214757/clinical-and-cytogenetic-profiles-of-rhabdomyosarcoma-with-bone-marrow-involvement-in-korean-children-a-15-year-single-institution-experience
#10
Dong Hyun Lee, Chan Jeoung Park, Seongsoo Jang, Young Uk Cho, Jong Jin Seo, Ho Joon Im, Kyung Nam Koh, Kyung Ja Cho, Joon Seon Song, Eul Ju Seo
BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Alveolar RMS (ARMS) is characterized by FOXO1-related chromosomal translocations that result in a poorer clinical outcome compared with embryonal RMS (ERMS). Because the chromosomal features of RMS have not been comprehensively defined, we analyzed the clinical and laboratory data of childhood RMS patients and determined the clinical significance of chromosomal abnormalities in the bone marrow. METHODS: Fifty-one Korean patients with RMS <18 years of age treated between 2001 and 2015 were enrolled in this study...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29211298/prognostic-relevance-of-early-radiologic-response-to-induction-chemotherapy-in-pediatric-rhabdomyosarcoma-a-report-from-the-international-society-of-pediatric-oncology-malignant-mesenchymal-tumor-95-study
#11
Bas Vaarwerk, Johanna H van der Lee, Willemijn B Breunis, Daniel Orbach, Julia C Chisholm, Nathalie Cozic, Meriel Jenney, Rick R van Rijn, Kieran McHugh, Soledad Gallego, Heidi Glosli, Christine Devalck, Mark N Gaze, Anna Kelsey, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Veronique Minard-Colin, Johannes H M Merks
BACKGROUND: Early response to induction chemotherapy is used in current European guidelines to evaluate the efficacy of chemotherapy and subsequently to adapt treatment in pediatric patients with rhabdomyosarcoma (RMS). However, existing literature on the prognostic value of early radiologic response on survival is contradictory; here the prognostic value is analyzed with data from the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor 95 (MMT-95) study. METHODS: This study examined 432 Intergroup Rhabdomyosarcoma Study Grouping III (macroscopic residue) patients enrolled in the SIOP MMT-95 study with a response assessment after 3 courses of chemotherapy (a 2-dimensional assessment)...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29204167/interstitial-brachytherapy-for-orbital-soft-tissue-sarcoma-an-innovative-technique
#12
Siddhartha Laskar, Avinash Pilar, Nehal Khanna, Yogesh Ghadi
Purpose: To report an innovative technique of interstitial brachytherapy developed for treatment of orbital soft tissue tumors. Material and methods: A 4-month-old child diagnosed with rhabdomyosarcoma of orbit was treated with multiagent chemotherapy (CTh) and brachytherapy. Pre-planning computed tomography (CT) images were obtained and clinical target volume (CTV) was defined using the pre-treatment magnetic resonance imaging (MRI). Brachytherapy plan was generated for deciding optimal catheter placement...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29200703/rhabdomyosarcoma-of-the-iliopsoas-a-retroperitoneal-misdiagnosis
#13
Animesh Ashutosh Upadhyay
Rhabdomyosarcoma (RMS) is a rare soft tissue sarcoma. The already documented data regarding RMS state that it is more prevalent in males than females and also that its occurrence is more in Caucasians than Asians. The current incidence of RMS is 4.5 cases/million, and thus, it is a very rare cancer. The undifferentiated type is the most aggressive one with a rare presentation in the retroperitoneum. Overall, this case emphasizes that consideration should be given to wide range of diagnosis and that frozen section is the gold standard for a confirmatory diagnosis, as the first biopsy showed benign cells within the tumor...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29200688/round-cell-tumors-classification-and-immunohistochemistry
#14
REVIEW
Shweta Sharma, R Kamala, Divya Nair, T Raju Ragavendra, Swapnil Mhatre, Robin Sabharwal, Basanta Kumar Choudhury, Vivek Rana
Round cell tumors as the name suggest are comprised round cells with increased nuclear-cytoplasmic ratio. This group of tumor includes entities such as peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilms' tumor, and desmoplastic small round cell tumor. These round cells tumors are characterized by typical histological pattern, immunohistochemical, and electron microscopic features that can help in differential diagnosis. The present article describes the classification and explains the histopathology and immunohistochemistry of some important round cell tumors...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29192742/biliary-tract-rhabdomyosarcoma-a-report-from-the-soft-tissue-sarcoma-committee-of-the-associazione-italiana-ematologia-oncologia-pediatrica
#15
Katia Perruccio, Valerio Cecinati, Angela Scagnellato, Massimo Provenzi, Giuseppe Maria Milano, Eleonora Basso, Carla Manzitti, Giovanni Cecchetto, Rita Alaggio, Martina Di Martino, Amalia Schiavetti, Fraia Melchionda, Maria Carmen Affinita, Stefano Chiaravalli, Lucia Miglionico, Rita Balter, Angela Tamburini, Gianni Bisogno, Andrea Ferrari
INTRODUCTION: Rhabdomyosarcoma is a soft tissue malignant musculoskeletal tumor frequent in children. Biliary duct localization is extremely rare, but it is the most common cause of malignant obstructive jaundice in pediatric patients. METHODS: This report describes a series of 10 patients under 18 years of age with biliary tract rhabdomyosarcoma who were enrolled, from 1979 to 2004, in 3 consecutive Italian pediatric cooperative protocols that had been drawn up by the Soft Tissue Sarcoma Committee of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)...
December 1, 2017: Tumori
https://www.readbyqxmd.com/read/29189868/-breast-osteosarcoma-originating-in-a-phyllodes-tumor-report-of-one-case
#16
Tereza Nieto-Coronel, Jessica Elizabeth Salazar-Campos, David Cantú de León, Raúl Díaz-Molina, Rafael Vázquez-Romo, Enrique Bargalló-Rocha
Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, chondrosarcomas or osteosarcomas. The differentiation to osteosarcoma is extremely rare, constitutes 1.3% of cases and is very aggressive. The standard treatment of these tumors is surgical. The role of radiotherapy and chemotherapy is not clear...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29186933/targeting-autophagy-in-alk-associated-cancers
#17
REVIEW
Julie Frentzel, Domenico Sorrentino, Sylvie Giuriato
Autophagy is an evolutionarily conserved catabolic process, which is used by the cells for cytoplasmic quality control. This process is induced following different kinds of stresses e.g., metabolic, environmental, or therapeutic, and acts, in this framework, as a cell survival mechanism. However, under certain circumstances, autophagy has been associated with cell death. This duality has been extensively reported in solid and hematological cancers, and has been observed during both tumor development and cancer therapy...
November 27, 2017: Cancers
https://www.readbyqxmd.com/read/29182526/immunohistochemical-analysis-of-rat-renal-tumours-caused-by-ochratoxin-a
#18
Diana Herman, Peter Mantle
Experimental renal cancer caused by ochratoxin A (OTA) in rats was first defined in the US National Toxicology Program (1989) and raised questions about any aetiological role in human urinary tract tumours. A review of histopathology in several rat kidney tumours from dietary OTA in recently described London studies, augmented by clinical immunohistochemistry for the first time for this mycotoxin, establishes their renal tubular cell origin. It had been assumed that the toxin might cause the human urothelial tumours associated with Balkan endemic nephropathy, but the present study could not support this...
November 28, 2017: Toxins
https://www.readbyqxmd.com/read/29173271/spontaneous-bladder-rupture-presenting-as-sudden-onset-abdominal-pain-in-a-child-after-many-years-in-remission-from-bladder-rhabdomyosarcoma
#19
Cyrus Chehroudi, Kourosh Afshar
Spontaneous bladder rupture is an uncommon event, especially in childhood. Here, we describe spontaneous bladder rupture seven years following treatment for bladder rhabdomyosarcoma in an otherwise healthy 11-year-old boy. This case highlights the importance of considering spontaneous bladder rupture as a cause for acute abdominal pain, especially in patients with prior urological history.
December 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29172920/clinicopathologic-features-of-benign-neurogenic-tumor-of-urinary-bladder
#20
Cheol Lee, Bohyun Kim, Boram Song, Jeong Hwan Park, Kyung Chul Moon
BACKGROUND: Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis is very important because the clinical course of each disease, even within the same diseases, is quite variable. In this study, we investigated 7 benign neurogenic tumors to better understand the rare disease entity in the urinary bladder by analyzing histological and immunohistochemical findings and comparing clinicopathologic features...
November 1, 2017: International Journal of Surgical Pathology
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