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https://www.readbyqxmd.com/read/28445631/treating-prolonged-grief-disorder-a-2-year-follow-up-of-a-randomized-controlled-trial
#1
Richard A Bryant, Lucy Kenny, Amy Joscelyne, Natasha Rawson, Fiona Maccallum, Catherine Cahill, Sally Hopwood, Angela Nickerson
BACKGROUND: Prolonged grief disorder (PGD) causes significant impairment in approximately 7% of bereaved people. Although cognitive-behavioral therapy (CBT) has been shown to effectively treat PGD, there is no evidence of long-term effects of CBT. OBJECTIVE: To determine the long-term efficacies of CBT with exposure or CBT without exposure in treating PGD by assessing outcome at 2 years. METHODS: A randomized controlled trial of PGD patients (N = 80) attending an outpatient clinic took place between September 2007 and June 2010, and a 2-year follow-up occurred between December 2009 and October 2012...
April 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28444209/variation-in-the-time-of-colonization-of-broiler-carcasses-by-carrion-flies-in-nakhonsawan-province-thailand
#2
Kittikhun Moophayak, Kabkaew L Sukontason, Watcharapong Ruankham, Jeffery K Tomberlin, Nophawan Bunchu
Carrion flies are the primary insects colonizing vertebrate carrion; however, limited information is available on the variation in the time of colonization (TOC) as related to time of placement (TOP) and time of death (TOD), particularly in Thailand. Three seasonal sets of nine broiler carcasses (euthanized and placed in field within 0.5 h after death) were placed in mesh enclosures within a disturbed deciduous dipterocarp forest at Nakhonsawan Province, upper-central Thailand, for 3 d to determine the colonization time by carrion flies...
April 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28443950/chronic-kidney-disease-determinants-of-progression-and-cardiovascular-risk-progredir-cohort-study-design-and-methods
#3
Maria Alice Muniz Domingos, Alessandra Carvalho Goulart, Paulo Andrade Lotufo, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters...
April 20, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28441339/still-searching-a-meta-synthesis-of-a-good-death-from-the-bereaved-family-member-perspective
#4
REVIEW
Kelly E Tenzek, Rachel Depner
The concept of a good death continues to receive attention in end-of-life (EOL) scholarship. We sought to continue this line of inquiry related to a good death by conducting a meta-synthesis of published qualitative research studies that examined a good death from the bereaved family member's perspective. Results of the meta-synthesis included 14 articles with 368 participants. Based on analysis, we present a conceptual model called The Opportunity Model for Presence during the EOL Process. The model is framed in socio-cultural factors, and major themes include EOL process engagement with categories of healthcare participants, communication and practical issues...
April 25, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28439103/brain-age-predicts-mortality
#5
J H Cole, S J Ritchie, M E Bastin, M C Valdés Hernández, S Muñoz Maniega, N Royle, J Corley, A Pattie, S E Harris, Q Zhang, N R Wray, P Redmond, R E Marioni, J M Starr, S R Cox, J M Wardlaw, D J Sharp, I J Deary
Age-associated disease and disability are placing a growing burden on society. However, ageing does not affect people uniformly. Hence, markers of the underlying biological ageing process are needed to help identify people at increased risk of age-associated physical and cognitive impairments and ultimately, death. Here, we present such a biomarker, 'brain-predicted age', derived using structural neuroimaging. Brain-predicted age was calculated using machine-learning analysis, trained on neuroimaging data from a large healthy reference sample (N=2001), then tested in the Lothian Birth Cohort 1936 (N=669), to determine relationships with age-associated functional measures and mortality...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28439098/uncoupling-dapk1-from-nmda-receptor-glun2b-subunit-exerts-rapid-antidepressant-like-effects
#6
S-X Li, Y Han, L-Z Xu, K Yuan, R-X Zhang, C-Y Sun, D-F Xu, M Yuan, J-H Deng, S-Q Meng, X-J Gao, Q Wen, L-J Liu, W-L Zhu, Y-X Xue, M Zhao, J Shi, L Lu
Several preclinical studies have reported the rapid antidepressant effects of N-methyl-D-aspartate receptor (NMDAR) antagonists, although the underlying mechanisms are still unclear. Death-associated protein kinase 1 (DAPK1) couples GluN2B subunits at extrasynaptic sites to regulate NMDAR channel conductance. In the present study, we found that chronic unpredictable stress (CUS) induced extracellular glutamate accumulation, accompanied by an increase in the DAPK1-NMDAR interaction, the high expression of DAPK1 and phosphorylated GluN2B at Ser1303, a decrease in phosphorylated DAPK1 at Ser308 and synaptic protein deficits in the rat medial prefrontal cortex (mPFC)...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28438446/the-association-of-hemodialysis-and-survival-in-intubated-salicylate-poisoned-patients
#7
Daniel J McCabe, Jenny J Lu
INTRODUCTION: Salicylate poisonings are common due to their multiple uses and wide availability. The variation of presenting symptoms contributes to inconsistent treatments in the emergency department. Patients with severe salicylate overdose require a high minute ventilation. Early in the course of an overdose, a patient will require hyperventilation. If they become too fatigued to compensate, mechanical ventilation may be needed. It can be impossible to recreate such a high minute ventilation with mechanical ventilation...
April 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28437210/factors-associated-with-length-of-stay-at-home-in-the-final-month-of-life-among-advanced-cancer-patients-a-retrospective-chart-review
#8
Masatomo Otsuka
BACKGROUND: Living at home is an important factor for maintaining high quality of life among patients. Many studies have discussed parameters associated with place of death, but no studies have yet clarified which factors influence the length of stay at home during the end of life. OBJECTIVE: The aim of this study was to identify factors influencing the amount of time spent at home during the final month of life among patients with advanced cancer. METHODS: A retrospective chart review was conducted for 415 patients with advanced cancer...
February 28, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28437201/the-impact-of-community-based-palliative-care-on-utilization-and-cost-of-acute-care-hospital-services-in-the-last-year-of-life
#9
David Youens, Rachael Moorin
BACKGROUND: Community-based palliative care may potentially benefit patients by offering their preferred care at the end of life and benefit systems by reducing hospital use. OBJECTIVE: To compare place of death and acute care hospital use in the last year of life between cancer decedents who did and did not access a community-based palliative care service (PCS). DESIGN: Retrospective observational cohort study using linked individual administrative records from cancer registry, hospital, emergency department (ED), mortality, and PCS databases...
February 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28436642/the-validity-of-race-and-hispanic-origin-reporting-on-death-certificates-in-the-united-states-an-update
#10
Elizabeth Arias, Melonie Heron, Jahn Hakes
Objectives This report presents the findings of an updated study of the validity of race and Hispanic-origin reporting on death certificates in the United States, and its impact on race- and Hispanic origin-specific death rates. Methods The latest version of the National Longitudinal Mortality Study (NLMS) was used to evaluate the classification of race and Hispanic origin on death certificates for deaths occurring in 1999–2011 to decedents in NLMS. To evaluate change over time, these results were compared with those of a study based on an earlier version of NLMS that evaluated the quality of race and ethnicity classification on death certificates for 1979–1989 and 1990–1998...
August 1, 2016: Vital and Health Statistics. Series 2, Data Evaluation and Methods Research
https://www.readbyqxmd.com/read/28436203/endoplasmic-reticulum-proteostasis-impairment-in-aging
#11
REVIEW
Gabriela Martínez, Claudia Duran-Aniotz, Felipe Cabral-Miranda, Juan P Vivar, Claudio Hetz
Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, folding, trafficking, secretion, and their degradation. A reduction in the buffering capacity of the proteostasis network during aging may increase the risk to undergo neurodegeneration by enhancing the accumulation of misfolded proteins. As almost one-third of the proteome is synthetized at the endoplasmic reticulum (ER), maintenance of its proper function is fundamental to sustain neuronal function...
April 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/28435669/reframing-the-science-and-policy-of-nicotine-illegal-drugs-and-alcohol-conclusions-of-the-alice-rap-project
#12
Peter Anderson, Virginia Berridge, Patricia Conrod, Robert Dudley, Matilda Hellman, Dirk Lachenmeier, Anne Lingford-Hughes, David Miller, Jürgen Rehm, Robin Room, Laura Schmidt, Roger Sullivan, Tamyko Ysa, Antoni Gual
In 2013, illegal drug use was responsible for 1.8% of years of life lost in the European Union, alcohol was responsible for 8.2% and tobacco for 18.2%, imposing economic burdens in excess of 2.5% of GDP. No single European country has optimal governance structures for reducing the harm done by nicotine, illegal drugs and alcohol, and existing ones are poorly designed, fragmented, and sometimes cause harm. Reporting the main science and policy conclusions of a transdisciplinary five-year analysis of the place of addictions in Europe, researchers from 67 scientific institutions addressed these problems by reframing an understanding of addictions...
2017: F1000Research
https://www.readbyqxmd.com/read/28435114/the-decussating-fibers-of-the-lumbar-thoracolumbar-fascia-a-landmark-for-identifying-the-l5-spinous-process
#13
Fernando Alonso, Tarush Rustagi, Christian Fisahn, Doniel Drazin, Brady Gardner, Joe Iwanaga, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: The thoracolumbar fascia has been well studied and is known to have crisscrossing fibers. Based on surgical experience, we have hypothesized that the decussating fibers of this fascia may indicate a specific vertebral level. Therefore, the following anatomical study was performed. METHODS: Twenty adult fresh frozen cadavers aged 72-84 years old at death were placed in the prone position and the skin of the lumbar and upper sacrum was removed. Careful attention was given to the thoracolumbar fascia and any fibers of it that grossly crossed the midline to inderdigitate with its contralateral counterpart...
April 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28434241/-facilitating-role-of-traumatic-experiences-in-art
#14
József Gerevich
Traumatic experiences can not only have unfavourable consequences, they can also contribute, with a kind of creative twist, to the development of the person affected by the trauma. The artistic responses to traumas can be examined on the basis of the different types of trauma. This study reports on an investigation focusing on six types of trauma: emotional deprivation/neglect; near-death experience; becoming the victim of violence; war; accident/sickness and emotional frustration. Examples taken from the history of art indicate that works of art can draw attention to the traumatic experiences of the artists with frequently repeated motifs and portrayal techniques (sun, mother image, objects referring to the person lost, motifs of violence or symbols of violence, artistic manifestations of an exaggerated self-image, surreal visions, dry irony, substituting other objects for the beloved person), or a sudden change of style and subject that can express a heightened interest in human suffering (Lovis Corinth)...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28431914/pain-trajectories-of-nursing-home-residents-nearing-death
#15
Genevieve N Thompson, Malcolm Doupe, R Colin Reid, Jennifer Baumbusch, Carole A Estabrooks
BACKGROUND/OBJECTIVES: Although examining point in time prevalence of pain among nursing home (NH) residents has value, there is a lack of evidence describing the actual changes (ie, trajectories) in pain that take place during their last 6 months of life. The main objective of this study is to describe the major pain trajectories experienced by NH residents during their last 6 months of life. DESIGN: Secondary analysis of Resident Assessment Instrument-Minimum Data Set (MDS) 2...
April 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28431500/foot-length-chest-and-head-circumference-measurements-in-detection-of-low-birth-weight-neonates-in-mekelle-ethiopia-a-hospital-based-cross-sectional-study
#16
Marta Yemane Hadush, Amanuel Hadgu Berhe, Araya Abrha Medhanyie
BACKGROUND: Low birth weight (Birth weight < 2500 g) is a leading cause of prenatal and neonatal deaths. The early identification of Low birth weight (LBW) neonates is essential for any comprehensive initiative to improve their chance of survival. However, a large proportion of births in developing countries take place at home and birth weight statistics are not available. Therefore, there is a need to develop simple, inexpensive and practical methods to identify low birth weight (LBW) neonates soon after birth...
April 21, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28429629/developing-indicators-of-appropriate-and-inappropriate-end-of-life-care-in-people-with-alzheimer-s-disease-cancer-or-chronic-obstructive-pulmonary-disease-for-population-level-administrative-databases-a-rand-ucla-appropriateness-study
#17
Robrecht De Schreye, Dirk Houttekier, Luc Deliens, Joachim Cohen
BACKGROUND: A substantial amount of aggressive life-prolonging treatments in the final stages of life has been reported for people with progressive life-shortening conditions. Monitoring appropriate and inappropriate end-of-life care is an important public health challenge and requires validated quality indicators. AIM: To develop indicators of appropriate and inappropriate end-of-life care for people with cancer, chronic obstructive pulmonary disease or Alzheimer's disease, measurable with population-level administrative data...
April 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28427964/scanning-electron-microscopic-studies-on-antenna-of-hemipyrellia-ligurriens-wiedemann-1830-diptera-calliphoridae-a-blow-fly-species-of-forensic-importance
#18
Garima Hore, Aniruddha Maity, Atanu Naskar, Waliza Ansar, Shyamasree Ghosh, Goutam Kumar Saha, Dhriti Banerjee
Blow flies (Diptera: Calliphoridae) are one of the foremost organisms amongst forensic insects to colonize corpses shortly after death, thus are of immense importance in the domain of forensic entomology. The blow fly Hemipyrellia ligurriens (Wiedemann, 1830) (Diptera: Calliphoridae) is considered as a forensically important fly species globally and is also known for its medical and veterinary importance. In the present study, we report for the first time scanning electron microscopic studies on the morphology of sensilla of antenna of adult male and female of H...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28427868/potential-palliative-care-quality-indicators-in-heart-disease-patients-a-review-of-the-literature
#19
REVIEW
Atsushi Mizuno, Mitsunori Miyashita, Akitoshi Hayashi, Fujimi Kawai, Koichiro Niwa, Akemi Utsunomiya, Shun Kohsaka, Takashi Kohno, Takeshi Yamamoto, Morimasa Takayama, Toshihisa Anzai
In spite of the increasing interest in palliative care for heart disease, data on the detailed methods of palliative care and its efficacy specifically in heart disease are still lacking. A structured PubMed literature review revealed no quality indicators of palliative care in heart disease. Therefore, we performed a narrative overview of the potential quality indicators in heart disease by reviewing previous literature concerning quality indicators in cancer patients. We summarize seven potential categories of quality indicators in heart disease: (1) presence and availability of a palliative care unit, palliative care team, and outpatient palliative care; (2) human resources such as number of skilled staff; (3) infrastructure; (4) presence and frequency of documentation or family survey; (5) patient-reported outcome measure (PROM) data and disease-specific patient quality of life such as The Kansas City Cardiomyopathy Questionnaire (KCCQ); (6) questionnaires and interviews about the quality of palliative care after death, including bereaved family surveys; and (7) admission-related outcomes such as place of death and intensive care unit length of stay...
April 17, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28427423/analysis-of-inequality-in-maternal-and-child-health-outcomes-and-mortality-from-2000-to-2013-in-china
#20
Yanting Li, Yimin Zhang, Shuai Fang, Shanshan Liu, Xinyu Liu, Ming Li, Hong Liang, Hua Fu
BACKGROUND: Inequality in maternal and child health seriously hinders the overall improvement of health, which is a concern in both the United Nations Sustainable Development Goals (SDGs) and Healthy China 2030. However, research on the equality of maternal and child health is scarce. This study longitudinally assessed the equality trends in China's maternal and child health outcomes from 2000 to 2013 based on place of residence and gender to improve the fairness of domestic maternal and child health...
April 20, 2017: International Journal for Equity in Health
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