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https://www.readbyqxmd.com/read/28097901/skin-whitening-agents-medicinal-chemistry-perspective-of-tyrosinase-inhibitors
#1
Thanigaimalai Pillaiyar, Manoj Manickam, Vigneshwaran Namasivayam
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 played a major role in melanin synthesis. Specifically, tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin synthesis, and the downregulation of tyrosinase is the most prominent approach for the development of melanogenesis inhibitors...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28076536/-quality-of-life-of-family-caregivers-of-adults-with-spinal-cord-injury-a-systematic-review
#2
Cejane Oliveira Martins Prudente, Maysa Ferreira Martins Ribeiro, Celmo Celeno Porto
The scope of this study was to analyze the quality of life of family caregivers of adults with spinal cord injury. Two researchers conducted a systematic review independently, based on articles published between 2000 to 2014, using the key words quality of life and caregivers or family and spinal cord, in Portuguese, English and Spanish. The search was conducted in the Virtual Health Library (BVS) and the United States National Library of Medicine (PubMED) databases. Caregivers of tetraplegics have a worse quality of life than caregivers of paraplegics...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28068355/a-methodology-for-cancer-therapeutics-by-systems-pharmacology-based-analysis-a-case-study-on-breast-cancer-related-traditional-chinese-medicines
#3
Yan Li, Jinghui Wang, Feng Lin, Yinfeng Yang, Su-Shing Chen
Breast cancer is the most common carcinoma in women. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effect and resistance against anticancer drugs. Complementary and alternative medicine (CAM) may avoid these problems, in which traditional Chinese medicine (TCM) has been highlighted. In this section, to analyze the mechanism through which TCM act on breast cancer, we have built a virtual model consisting of the construction of database, oral bioavailability prediction, drug-likeness evaluation, target prediction, network construction...
2017: PloS One
https://www.readbyqxmd.com/read/28056962/an-investigation-of-professionalism-reflected-by-student-comments-on-formative-virtual-patient-encounters
#4
Ting Dong, William Kelly, Meredith Hays, Norman B Berman, Steven J Durning
BACKGROUND: This study explored the use of virtual patient generated data by investigating the association between students' unprofessional patient summary statements, which they entered during an on-line virtual patient case, and detection of their future unprofessional behavior. METHOD: At the USUHS, students complete a number of virtual patient encounters, including a patient summary, to meet the clerkship requirements of Internal Medicine, Family Medicine, and Pediatrics...
January 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28038897/herbal-supplements-association-with-reversible-cerebral-vasoconstriction-syndrome-a-case-report
#5
Isabel Costa, Marcelo D Mendonça, Vera Cruz E Silva, Sofia Calado, Miguel Viana-Baptista
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a clinico-radiologic syndrome characterized by thunderclap headache and reversible multifocal arterial constrictions that resolves within 3 months. RCVS can be either spontaneous or related to a trigger; vasoactive drugs including over-the-counter medicine are common culprits. Nevertheless, there are sparse data on the association of herbal supplements in the genesis of unexplained RCVS. METHODS: We describe a case of RCVS with a temporal association with the consumption of a diet pill composed of green tea, L-carnitine, and conjugated linoleic acid...
December 27, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28032173/clinical-outcomes-and-complications-associated-with-fractional-lasers-a-review-of-730-patients
#6
Steven R Cohen, Ashley Goodacre, Soobin Lim, Jennifer Johnston, Cory Henssler, Brian Jeffers, Ahmad Saad, Tracy Leong
BACKGROUND: Fractional lasers were introduced to provide increased safety, while maintaining high efficacy and patient satisfaction. Patients with virtually all Fitzpatrick skin types could be safely treated using a wide spectrum of wavelengths and a broad array of skin conditions, and aging could be addressed. Although safety studies have been reported for ablative CO2 and erbium lasers, surprisingly few data are available on adverse events and complications associated with fractional lasers...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28025679/vascular-anatomical-relationships-of-the-retropubic-space-and-the-sacrospinous-ligament-using-three-dimensional-imaging
#7
Omar F Dueñas-Garcia, Youngwu Kim, Katherine Leung, Michel K Flynn
INTRODUCTION AND HYPOTHESIS: Pelvic anatomy is complex and intimate knowledge of variabilities in anatomical relationships is critical for surgeons to safely perform surgical procedures. Three-dimensional Imaging provides the opportunity to analyze undisturbed anatomical relationships. The authors hypothesized that three-dimensional models created from pelvic computed tomography angiograms could be used to obtain vascular anatomical measurements, and that the measurements obtained from three-dimensional models would be similar to those from cadaver studies...
December 26, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/28007642/suppressing-effect-of-saikosaponin-a-an-active-ingredient-of-bupleurum-falcatum-on-chocolate-self-administration-and-reinstatement-of-chocolate-seeking-in-rats
#8
Irene Lorrai, Paola Maccioni, Mauro A M Carai, Alessandro Capra, M Paola Castelli, Antonella Riva, Paolo Morazzoni, Gian Luigi Gessa, Giancarlo Colombo
Recent lines of experimental evidence have indicated that saikosaponin A (SSA) - a bioactive ingredient of the medicinal plant, Bupleurum falcatum L. - suppressed alcohol, morphine, and cocaine self-administration in rats. The present paper was designed to assess whether the protective properties of SSA on addiction-related behaviors generalize to a hyperpalatable food such as a chocolate-flavored beverage (CFB). To this end, rats were initially trained to lever-respond for CFB [5% (w/v) Nesquik(®) powder in water] under fixed ratio (FR) 10 (FR10) schedule of reinforcement...
December 19, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27992349/design-and-psychophysical-evaluation-of-the-hapsticks-a-novel-non-grounded-mechanism-for-presenting-tool-mediated-vertical-forces
#9
Ginga Kato, Yoshihiro Kuroda, Ilana Nisky, Kiyoshi Kiyokawa, Haruo Takemura
Force feedback in tool-mediated interactions with the environment is important for the successful performance of complex tasks in daily life as well as in specialized fields such as medicine. Most stylus-based haptic devices require either grounding or attachment to the user's body. Recently, non-grounded haptic devices have attracted a growing interest. In this study, we propose a non-grounded rotation mechanism to represent the vertical forces applied on the tip of a tool by mimicking the cutaneous sensations that are caused by such forces...
December 12, 2016: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/27986645/cardiopulmonary-resuscitation-training-by-avatars-a-qualitative-study-of-medical-students-experiences-using-a-multiplayer-virtual-world
#10
Johan Creutzfeldt, Leif Hedman, Li Felländer-Tsai
BACKGROUND: Emergency medical practices are often team efforts. Training for various tasks and collaborations may be carried out in virtual environments. Although promising results exist from studies of serious games, little is known about the subjective reactions of learners when using multiplayer virtual world (MVW) training in medicine. OBJECTIVE: The objective of this study was to reach a better understanding of the learners' reactions and experiences when using an MVW for team training of cardiopulmonary resuscitation (CPR)...
December 16, 2016: JMIR Serious Games
https://www.readbyqxmd.com/read/27983650/discovery-of-anti-hypertensive-oligopeptides-from-adlay-based-on-in-silico-proteolysis-and-virtual-screening
#11
Liansheng Qiao, Bin Li, Yankun Chen, Lingling Li, Xi Chen, Lingzhi Wang, Fang Lu, Ganggang Luo, Gongyu Li, Yanling Zhang
Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM) with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay have been proven to be anti-hypertensive effective components. However, the structures and anti-hypertensive mechanism of bioactive oligopeptides from adlay were not clear. To discover the definite anti-hypertensive oligopeptides from adlay, in silico proteolysis and virtual screening were implemented to obtain potential oligopeptides, which were further identified by biochemistry assay and molecular dynamics simulation...
December 14, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27982376/use-of-generic-medicines-by-the-brazilian-population-an-evaluation-of-pnaum-2014
#12
Andréa Dâmaso Bertoldi, Paulo Sergio Dourado Arrais, Noemia Urruth Leão Tavares, Luiz Roberto Ramos, Vera Lucia Luiza, Sotero Serrate Mengue, Tatiane da Silva Dal-Pizzol, Mareni Rocha Farias, Maria Auxiliadora Oliveira
OBJECTIVE: To analyze the existence of differences in the use of generic medicines in Brazil according to demographic and socioeconomic variables and acquisition sources of the medicines. METHODS: Population-based cross-sectional study, conducted with data from the Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines). Data collection took place between September, 2013 and February, 2014 in homes of Brazilian cities (urban area)...
December 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27977293/development-of-a-sleep-telementorship-program-for-rural-department-of-veterans-affairs-primary-care-providers-sleep-va-echo
#13
Elizabeth C Parsons, Elizabeth A Mattox, Lauren A Beste, David H Au, Bessie A Young, Michael F Chang, Brian N Palen
RATIONALE: Primary care providers (PCPs) frequently encounter sleep complaints, especially in regions with limited specialty care access. OBJECTIVES: The US Department of Veterans Affairs Extension for Community Healthcare Outcomes (VA-ECHO) program (based on Project ECHO) has successfully provided rural PCP education in subspecialty areas, including hepatitis C. We describe the feasibility of an ECHO program for sleep medicine. METHODS: ECHO creates a virtual learning community through video-teleconferencing, combining didactics with individualized clinical case review...
December 15, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27974948/utilizing-chair-massage-to-address-one-woman-s-health-in-rural-ghana-west-africa-a-case-report
#14
Cathy J Meryanos
BACKGROUND AND OBJECTIVES: There is limited access to health care in rural Ghana and virtually no rehabilitative services available. This situation presents a unique opportunity to utilize chair massage in addressing women's health in rural Ghana, particularly when it comes to muscle pain and fatigue from heavy labor. The objective of this case report is to determine the results of chair massage as a strategy to reduce neck, shoulder, and back pain, while increasing range of motion. CASE PRESENTATION: The patient is a 63-year-old Ghanaian female, who was struck by a public transport van while carrying a 30-50 pound load on her head, two years prior...
December 2016: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/27973962/computer-assisted-virtual-preoperative-planning-in-orthopedic-surgery-for-acetabular-fractures-based-on-actual-computed-tomography-data
#15
Guang-Ye Wang, Wen-Jun Huang, Qi Song, Yun-Tian Qin, Jin-Feng Liang
Acetabular fractures have always been very challenging for orthopedic surgeons; therefore, appropriate preoperative evaluation and planning are particularly important. This study aimed to explore the application methods and clinical value of preoperative computer simulation (PCS) in treating pelvic and acetabular fractures. Spiral computed tomography (CT) was performed on 13 patients with pelvic and acetabular fractures, and Digital Imaging and Communications in Medicine (DICOM) data were then input into Mimics software to reconstruct three-dimensional (3D) models of actual pelvic and acetabular fractures for preoperative simulative reduction and fixation, and to simulate each surgical procedure...
December 2016: Comput Assist Surg (Abingdon)
https://www.readbyqxmd.com/read/27968881/a-smartphone-based-exercise-adherence-intervention-for-people-with-metabolic-syndrome-a-feasibility-pilot-study
#16
Janet Wh Sit, Sek-Ying Chair, Stanley Sc Hui, Kai-Chow Choi, Aileen Wk Chan, Eliza Ml Wong, Ho-Yu Cheng
BACKGROUND: Despite well-established benefits of exercise in the management of metabolic syndrome, evidence to support exercise adherence after program completion is lacking. We used a smartphone-based exercise adherence intervention (Virtual Trainer; Ex-VT) for adults with metabolic syndrome in Hong Kong, China. The objectives were to measure the feasibility, potential effectiveness, and implementation of Ex-VT in sustaining prescribed exercise practice for risk reduction in metabolic syndrome...
October 2016: Lancet
https://www.readbyqxmd.com/read/27955651/learning-pathology-using-collaborative-vs-individual-annotation-of-whole-slide-images-a-mixed-methods-trial
#17
Michael Sahota, Betty Leung, Stephanie Dowdell, Gary M Velan
BACKGROUND: Students in biomedical disciplines require understanding of normal and abnormal microscopic appearances of human tissues (histology and histopathology). For this purpose, practical classes in these disciplines typically use virtual microscopy, viewing digitised whole slide images in web browsers. To enhance engagement, tools have been developed to enable individual or collaborative annotation of whole slide images within web browsers. To date, there have been no studies that have critically compared the impact on learning of individual and collaborative annotations on whole slide images...
December 12, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27935308/combining-molecular-scaffolds-from-fda-approved-drugs-application-to-drug-discovery
#18
Richard D Taylor, Malcolm MacCoss, Alastair D G Lawson
We have enumerated all linear combinations of ring systems from FDA approved drugs, up to three rings in length and up to four bonds linkers to give an in silico database of approximately 14 million molecules. This virtual library was compared with molecular databases of published and commercially available compounds to assess the prevalence of drug ring combinations in modern medicinal chemistry and to identify areas of under-represented, but clinically validated, chemical space. From the 10 trillion molecular comparisons, we found that less than 1% of the possible combinations of drug ring systems appear in commercially available libraries...
December 23, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27924552/what-is-behavioural-medicine-commentary-on-definition-proposed-by-dekker-stauder-and-penedo
#19
Marie Johnston, Derek Johnston
PURPOSE: Dekker et al. (2016) propose an updated definition of behavioural medicine. METHOD: In this commentary, we discuss how the field and the disciplines involved have changed over time before suggesting small amendments to the proposed definition. RESULTS: We suggest that the range of medicine which might be considered 'behavioural' is increasing to encompass virtually all medical practice. In addition, the role of behaviour and the potential for behaviour change as a means of improving health have become increasingly important...
December 6, 2016: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/27920397/optimizing-combination-therapy-for-acute-lymphoblastic-leukemia-using-a-phenotypic-personalized-medicine-digital-health-platform
#20
Dong-Keun Lee, Vivian Y Chang, Theodore Kee, Chih-Ming Ho, Dean Ho
Acute lymphoblastic leukemia (ALL) is a blood cancer that is characterized by the overproduction of lymphoblasts in the bone marrow. Treatment for pediatric ALL typically uses combination chemotherapy in phases, including a prolonged maintenance phase with oral methotrexate and 6-mercaptopurine, which often requires dose adjustment to balance side effects and efficacy. However, a major challenge confronting combination therapy for virtually every disease indication is the inability to pinpoint drug doses that are optimized for each patient, and the ability to adaptively and continuously optimize these doses to address comorbidities and other patient-specific physiological changes...
December 1, 2016: Journal of Laboratory Automation
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