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https://www.readbyqxmd.com/read/29776631/molecular-pathology-in-transfusion-medicine-new-concepts-and-applications
#1
REVIEW
Matthew B Elkins, Robertson D Davenport, Martin H Bluth
Virtually all the red blood cell and platelet antigen systems have been characterized at the molecular level. Highly reliable methods for red blood cell and platelet antigen genotyping are now available. Genotyping is a useful adjunct to traditional serology and can help resolve complex serologic problems. Although red blood cell and platelet phenotypes can be inferred from genotype, knowledge of the molecular basis is essential for accurate assignment. Genotyping of blood donors is an effective method of identifying antigen-negative and/or particularly rare donors...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29770294/three-dimensional-modelling-and-three-dimensional-printing-in-pediatric-and-congenital-cardiac-surgery
#2
REVIEW
Laszlo Kiraly
Three-dimensional (3D) modelling and printing methods greatly support advances in individualized medicine and surgery. In pediatric and congenital cardiac surgery, personalized imaging and 3D modelling presents with a range of advantages, e.g., better understanding of complex anatomy, interactivity and hands-on approach, possibility for preoperative surgical planning and virtual surgery, ability to assess expected results, and improved communication within the multidisciplinary team and with patients. 3D virtual and printed models often add important new anatomical findings and prompt alternative operative scenarios...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29764343/virtual-medicine-how-virtual-reality-is-easing-pain-calming-nerves-and-improving-health
#3
Brennan Mr Spiegel
No abstract text is available yet for this article.
May 21, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29748435/end-of-treatment-and-serial-pet-imaging-in-primary-mediastinal-b-cell-lymphoma-following-dose-adjusted-epoch-r-a-paradigm-shift-in-clinical-decision-making
#4
Christopher Melani, Ranjana Advani, Mark Roschewski, Kelsey M Walters, Clara C Chen, Lucia Baratto, Mark A Ahlman, Milos D Miljkovic, Seth M Steinberg, Jessica Lam, Margaret Shovlin, Kieron Dunleavy, Stefania Pittaluga, Elaine S Jaffe, Wyndham H Wilson
Dose-adjusted-EPOCH-R obviates the need for radiotherapy in most patients with primary mediastinal B-cell lymphoma. End-of-treatment PET, however, does not accurately identify patients at risk of treatment failure, thereby confounding clinical decision making. To define the role of PET in primary mediastinal B-cell lymphoma following dose-adjusted-EPOCH-R, we extended enrollment and follow-up on our published phase II trial and independent series. Ninety-three patients received dose-adjusted-EPOCH-R without radiotherapy...
May 10, 2018: Haematologica
https://www.readbyqxmd.com/read/29738972/steroids-from-ganoderma-sinense-as-new-natural-inhibitors-of-cancer-associated-mutant-idh1
#5
Mengzhu Zheng, Ruotian Tang, Yue Deng, Kaiyin Yang, Lixia Chen, Hua Li
Isocitrate dehydrogenase (IDH) is one of the key enzymes in the tricarboxylic acid cycle, and IDH mutations have been associated with many cancers, including glioblastoma, sarcoma, acute myeloid leukemia, etc. Three natural steroids 1-3 from Ganoderma sinense, a unique and rare edible-medicinal fungi in China, were found as potential IDH1 inhibitors by virtual ligand screening method. Among the three compounds, 3 showed the highest binding affinity to IDH1 with significant calculated binding free energy. Enzymatic kinetics demonstrated that 3 inhibited mutant enzyme in a noncompetitive manner...
April 30, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29734285/a-systematic-literature-review-of-instruments-to-measure-coordination
#6
Candice L Thomas, Christiane Spitzmüller, Amber B Amspoker, Varsha Modi, Thach Tran, Aanand D Naik, LeChauncy Woodard, Amanda Auron, Sylvia J Hysong
Organizing patient care and improving team coordination have been identified by the Institute of Medicine and the Agency for Healthcare Research and Quality as essential components of high-quality care. Research is lacking, however, on the measurement of care team coordination and its mechanisms. Using an organizational psychology framework developed by Okhuysen and Bechky (O&B) as a guide, the authors identify strengths and gaps in the existing literature related to the measurement of coordination and its associated constructs...
May 2018: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/29732444/rosettaligandensemble-a-small-molecule-ensemble-driven-docking-approach
#7
Darwin Yu Fu, Jens Meiler
RosettaLigand is a protein-small-molecule (ligand) docking software capable of predicting binding poses and is used for virtual screening of medium-sized ligand libraries. Structurally similar small molecules are generally found to bind in the same pose to one binding pocket, despite some prominent exceptions. To make use of this information, we have developed RosettaLigandEnsemble (RLE). RLE docks a superimposed ensemble of congeneric ligands simultaneously. The program determines a well-scoring overall pose for this superimposed ensemble before independently optimizing individual protein-small-molecule interfaces...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#8
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29727412/evidence-based-medicine-in-pediatric-orthopaedics-evidence-based-practice-committee-summary-of-levels-of-evidence-clinical-practice-guidelines-appropriate-use-criteria-and-best-practice-guidelines
#9
Jigar S Gandhi, Kevin G Shea, Paul D Sponseller, Brian K Brighton, Theodore J Ganley
The concept of evidence-based medicine has evolved over the past 2 decades, and has become a cornerstone to clinical decision-making in virtually every aspect of medicine. With a commitment to providing its members with high-quality evidence-based guidelines, the American Academy of Orthopaedic Surgeons has instituted concerted efforts since 2006 to develop clinical practice guidelines (CPGs) and appropriate use criteria (AUCs) for certain orthopaedic conditions. Many of these CPGs and AUCs detail the management of pediatric orthopaedic conditions...
April 30, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29725591/the-mu-ta-lig-chemotheca-a-community-populated-molecular-database-for-multi-target-ligands-identification-and-compound-repurposing
#10
Francesco Ortuso, Donatella Bagetta, Annalisa Maruca, Carmine Talarico, Maria L Bolognesi, Norbert Haider, Fernanda Borges, Sharon Bryant, Thierry Langer, Hanoch Senderowitz, Stefano Alcaro
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optimal pharmacological profile. However, some poorly active or even inactive compounds could live a second life if tested against other targets. Thus, new therapeutic opportunities could emerge and synergistic activities could be identified and exploited for existing compounds by sharing information between researchers who are working on different targets...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29722730/virtual-reality-exploration-and-planning-for-precision-colorectal-surgery
#11
Ludovica Guerriero, Giuseppe Quero, Michele Diana, Luc Soler, Vincent Agnus, Jacques Marescaux, Francesco Corcione
BACKGROUND: Medical software can build a digital clone of the patient with 3-dimensional reconstruction of Digital Imaging and Communication in Medicine images. The virtual clone can be manipulated (rotations, zooms, etc), and the various organs can be selectively displayed or hidden to facilitate a virtual reality preoperative surgical exploration and planning. OBJECTIVE: We present preliminary cases showing the potential interest of virtual reality in colorectal surgery for both cases of diverticular disease and colonic neoplasms...
June 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29720039/palliative-medicine-advance-care-planning-virtual-issue
#12
Sarah Russell
Since the latter part of the twentith century, international research, education and practice of advance care planning has experienced a diversity of developments and defintions. Whilst this variety may seem bewildering, a continued commitment to accurate, focussed research enables better care through better understanding and better evidence.
May 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29710800/discovery-of-potential-inhibitors-of-squalene-synthase-from-traditional-chinese-medicine-based-on-virtual-screening-and-in-vitro-evaluation-of-lipid-lowering-effect
#13
Yankun Chen, Xi Chen, Ganggang Luo, Xu Zhang, Fang Lu, Liansheng Qiao, Wenjing He, Gongyu Li, Yanling Zhang
Squalene synthase (SQS), a key downstream enzyme involved in the cholesterol biosynthetic pathway, plays an important role in treating hyperlipidemia. Compared to statins, SQS inhibitors have shown a very significant lipid-lowering effect and do not cause myotoxicity. Thus, the paper aims to discover potential SQS inhibitors from Traditional Chinese Medicine (TCM) by the combination of molecular modeling methods and biological assays. In this study, cynarin was selected as a potential SQS inhibitor candidate compound based on its pharmacophoric properties, molecular docking studies and molecular dynamics (MD) simulations...
April 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29704554/growth-physiological-antioxidants-and-immune-response-of-african-catfish-clarias-gariepinus-b-to-dietary-clove-basil-ocimum-gratissimum-leaf-extract-and-its-susceptibility-to-listeria-monocytogenes-infection
#14
Mohsen Abdel-Tawwab, Ibrahim Adeshina, Adetola Jenyo-Oni, Emmanual K Ajani, Benjami O Emikpe
Clove basil, Ocimum gratissimum, is a native plant to Africa and grows virtually in tropical and subtropical regions. It has good aroma and its leaves have become used as a spicy and in traditional medicine. The use of plant leaves in fish diets may deteriorate their growth because it may content anti-nutritional factors0 Thus, it is better to use plants leaves extract. In the current study, clove basil leaves extract (CBLE) was administrated to African catfish, Clarias gariepinus (B.) for 12 weeks to evaluate its effect on growth performance, physiological, antioxidants, and innate immunity variables...
April 25, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29699925/discovery-of-d-amino-acid-oxidase-inhibitors-based-on-virtual-screening-against-the-lid-open-enzyme-conformation
#15
Bence Szilágyi, Žiga Skok, Anita Rácz, Rok Frlan, György G Ferenczy, Janez Ilaš, György M Keserű
d-Amino acid oxidase (DAAO) inhibitors are typically small polar compounds with often suboptimal pharmacokinetic properties. Features of the native binding site limit the operational freedom of further medicinal chemistry efforts. We therefore initiated a structure based virtual screening campaign based on the X-ray structures of DAAO complexes where larger ligands shifted the loop (lid opening) covering the native binding site. The virtual screening of our in-house collection followed by the in vitro test of the best ranked compounds led to the identification of a new scaffold with micromolar IC50 ...
April 20, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29696101/curriculum-design-and-implementation-of-the-emergency-medicine-chief-resident-incubator
#16
Michael A Gisondi, Adaira Chou, Nikita Joshi, Margaret K Sheehy, Fareen Zaver, Teresa M Chan, Jeffrey Riddell, Derek P Sifford, Michelle Lin
Background Chief residents receive minimal formal training in preparation for their administrative responsibilities. There is a lack of professional development programs specifically designed for chief residents. Objective In 2015, Academic Life in Emergency Medicine designed and implemented an annual, year-long, training program and virtual community of practice for chief residents in emergency medicine (EM). This study describes the curriculum design process and reports measures of learner engagement during the first two cycles of the curriculum...
February 24, 2018: Curēus
https://www.readbyqxmd.com/read/29695278/global-landscape-assessment-of-screening-technologies-for-medicine-quality-assurance-stakeholder-perceptions-and-practices-from-ten-countries
#17
Lukas Roth, Ameena Nalim, Beth Turesson, Laura Krech
BACKGROUND: The spread of substandard and falsified (SF) medical products constitutes a growing global public health concern. Some countries use portable, handheld screening technologies (STs) in the field to accelerate detection of SF medicines and reduce the number of medicine samples that undergo costly and time-consuming confirmatory analysis. METHODS: A multi-country, multi-stakeholder landscape assessment utilizing qualitative methodology was used to examine practices and perceptions related to the use of STs...
April 25, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29686255/presence-and-user-experience-in-a-virtual-environment-under-the-influence-of-ethanol-an-explorative-study
#18
Mario Lorenz, Jennifer Brade, Lisa Diamond, Daniel Sjölie, Marc Busch, Manfred Tscheligi, Philipp Klimant, Christoph-E Heyde, Niels Hammer
Virtual Reality (VR) is used for a variety of applications ranging from entertainment to psychological medicine. VR has been demonstrated to influence higher order cognitive functions and cortical plasticity, with implications on phobia and stroke treatment. An integral part for successful VR is a high sense of presence - a feeling of 'being there' in the virtual scenario. The underlying cognitive and perceptive functions causing presence in VR scenarios are however not completely known. It is evident that the brain function is influenced by drugs, such as ethanol, potentially confounding cortical plasticity, also in VR...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679721/effectiveness-evaluation-of-digital-virtual-simulation-application-in-teaching-of-gross-anatomy
#19
Xiaohua Deng, Guowei Zhou, Bing Xiao, Zirui Zhao, Yicheng He, Chujun Chen
INTRODUCTION: digital virtual simulation (DVS) is increasingly used to supplement the teaching of anatomy. DVS can provide the students with three-dimensional (3D) stereoscopic images and precise structures in anatomy teaching. We investigated the effects of digital virtual simulation (DVS) application in gross anatomy teaching. MATERIALS AND METHODS: fourth-year medical students (n=120), majoring clinical medicine in 2013 grade from Xiangya School of Medicine, Central South University, were assigned into four classes...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29675359/three-dimensional-speckle-tracking-echocardiography-detects-different-patterns-of-right-atrial-dysfunction-in-selected-disorders-a-short-summary-from-the-magyar-path-study
#20
Attila Nemes, Péter Domsik, Anita Kalapos, Árpád Kormányos, Nóra Ambrus, Tamás Forster
The right atrium (RA) is the most under-evaluated heart chamber in the clinical practice. Three-dimensional (3D) speckle-tracking echocardiography (STE) merges the benefits of 3D echocardiography and STE: volumetric and strain assessment of the RA can be performed at the same time from the same digitally acquired 3D echocardiographic dataset with a special equipment using a virtual 3D model of the RA. A diagnostic focused study is under way at the Second Department of Medicine and Cardiology Center, University of Szeged, Hungary to assess 3D-STE-derived RA variables in different patient populations, which serves as a substudy of Motion Analysis of the heart and Great vessels bY three-dimensionAl speckle-tRacking echocardiography in Pathological cases (MAGYAR-Path) Study...
March 2018: Quantitative Imaging in Medicine and Surgery
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