keyword
https://read.qxmd.com/read/38546649/participation-in-virtual-prehabilitation-and-outcomes-following-thoracic-cancer-surgery
#1
JOURNAL ARTICLE
Jun J Mao, Daniela Molena, Krupali Desai, Raymond E Baser, Christina Seluzicki, Gaetano Rocco, David Jones
No abstract text is available yet for this article.
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38545902/drug-design-do-not-forget-the-supramolecular-factor
#2
REVIEW
Steven L Regen
A major challenge currently facing medicinal chemists is designing agents that can selectively destroy drug resistant fungi and bacteria that have begun to emerge. One factor that has been overlooked by virtually all drug discovery/development approaches is the supramolecular factor, in which aggregated forms of a drug candidate exhibit low selectivity in destroying targeted cells while the corresponding monomers exhibit high selectivity. This Perspective discusses how we were led to the supramolecular factor through fundamental studies with simple model systems, how we reasoned that the selectivity of monomers of the antifungal agent amphotericin B should be much greater than the selectivity of the corresponding aggregates, and how we confirmed this hypothesis using derivatives of amphotericin B...
March 28, 2024: Biochemistry
https://read.qxmd.com/read/38545718/visual-aid-for-pediatric-virtual-musculoskeletal-exams-a-barbie-girl-in-a-telehealth-world
#3
JOURNAL ARTICLE
Alyssa K Cook, Britney M Papp, Claire Z Kalpakjian, Alecia K Daunter
BACKGROUND: Telehealth is rapidly advancing, yet musculoskeletal physical examinations pose a unique challenge with limited clinically tested tools. OBJECTIVE: To measure whether visual aid use improves accuracy and efficiency of musculoskeletal exam maneuvers within a mock pediatric telehealth encounter. DESIGN: Randomized controlled trial. SETTING: Mock telehealth encounter. PARTICIPANTS: A total of 30 volunteer dyads of children aged 4-17 years old and their parent/guardian...
March 28, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/38545691/virtual-reality-training-versus-conventional-rehabilitation-for-chronic-neck-pain-a-systematic-review-and-meta-analysis
#4
REVIEW
Jie Hao, Zhengting He, Ziyan Chen, Andréas Remis
OBJECTIVE: To identify, critically appraise, and quantitatively synthesize current randomized controlled trials to compare the effects of virtual reality and dose-matched conventional exercises in patients with chronic neck pain. LITERATURE SEARCH: PubMed, Embase, CINAHL, PsycINFO, and Scopus were searched for studies published prior to April 15, 2023. The search strategies combined controlled vocabularies and title/abstract keywords on search themes of virtual reality and neck pain...
March 28, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/38545520/effect-of-virtual-reality-on-sleep-deprived-individuals
#5
JOURNAL ARTICLE
Jeba Chitra, Marissa De Souza Eremita
BACKGROUND: Sleep deprivation (SD) refers to getting less than the required amount of sleep, which for adults ranges from 7 to 9 h of sleep per night and can be caused by social and biological factors. College students experience SD, which can affect their academic performance, health, and mood. Virtual Reality Therapy (VRT), an upcoming method of intervention, has been used in other psychological conditions with positive outcomes. The purpose of this study was to determine the effect of VRT on individuals with SD...
November 2023: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/38545083/synthesis-of-virtual-monoenergetic-images-from-kilovoltage-peak-images-using-wavelet-loss-enhanced-cyclegan-for-improving-radiomics-features-reproducibility
#6
JOURNAL ARTICLE
Zilong Xu, Miaomiao Li, Baosheng Li, Huazhong Shu
BACKGROUND: Dual-energy computed tomography (CT) can provide a range of image information beyond conventional CT through virtual monoenergetic images (VMIs). The purpose of this study was to investigate the impact of material decomposition in detector-based spectral CT on radiomics features and effectiveness of using deep learning-based image synthesis to improve the reproducibility of radiomics features. METHODS: In this paper, spectral CT image data from 45 esophageal cancer patients were collected for investigation retrospectively...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38543181/digital-technology-applications-in-the-management-of-adverse-drug-reactions-bibliometric-analysis
#7
JOURNAL ARTICLE
Olena Litvinova, Andy Wai Kan Yeung, Fabian Peter Hammerle, Michel-Edwar Mickael, Maima Matin, Maria Kletecka-Pulker, Atanas G Atanasov, Harald Willschke
Adverse drug reactions continue to be not only one of the most urgent problems in clinical medicine, but also a social problem. The aim of this study was a bibliometric analysis of the use of digital technologies to prevent adverse drug reactions and an overview of their main applications to improve the safety of pharmacotherapy. The search was conducted using the Web of Science database for the period 1991-2023. A positive trend in publications in the field of using digital technologies in the management of adverse drug reactions was revealed...
March 19, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542866/discovery-of-novel-noncovalent-kras-g12d-inhibitors-through-structure-based-virtual-screening-and-molecular-dynamics-simulations
#8
JOURNAL ARTICLE
Zhenya Du, Gao Tu, Yaguo Gong, Xiangzheng Fu, Qibiao Wu, Guankui Long
The development of effective inhibitors targeting the Kirsten rat sarcoma viral proto-oncogene (KRASG12D ) mutation, a prevalent oncogenic driver in cancer, represents a significant unmet need in precision medicine. In this study, an integrated computational approach combining structure-based virtual screening and molecular dynamics simulation was employed to identify novel noncovalent inhibitors targeting the KRASG12D variant. Through virtual screening of over 1.7 million diverse compounds, potential lead compounds with high binding affinity and specificity were identified using molecular docking and scoring techniques...
March 10, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38541976/a-rand-ucla-modified-vas-study-on-telemedicine-telehealth-and-virtual-care-in-daily-clinical-practice-of-vascular-medicine
#9
JOURNAL ARTICLE
Sergio Pillon, Georgia Gomatou, Evangelos Dimakakos, Agata Stanek, Zsolt Pecsvarady, Matija Kozak, Jean-Claude Wautrecht, Katalin Farkas, Gerit-Holger Schernthaner, Mariella Catalano, Aleš Blinc, Grigorios Gerotziafas, Pavel Poredoš, Sergio De Marchi, Michael E Gschwandtner, Endre Kolossváry, Muriel Sprynger, Bahar Fazeli, Aaron Liew, Peter Marschang, Andrzej Szuba, Dusan Suput, Michael Edmonds, Chris Manu, Christian Alexander Schaefer, George Marakomichelakis, Majda Vrkić Kirhmajer, Jonas Spaak, Elias Kotteas, Gianfranco Lessiani, Mary Paola Colgan, Marc Righini, Michael Lichtenberg, Oliver Schlager, Caitriona Canning, Antonella Marcoccia, Anastasios Kollias, Alberta Spreafico
Background: Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of telemedicine in vascular medicine. Methods: A clinical guidance group proposed a set of 67 clinical practice recommendations based on the synthesis of current evidence and expert opinion. The Telemedicine Vascular Medicine Working Group included 32 experts from Europe evaluating the appropriateness of each clinical practice recommendation based on published RAND/UCLA methodology in two rounds...
March 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541894/quantification-and-influence-of-il-1%C3%AE-on-pain-and-inflammatory-response-after-placement-of-a-cement-screw-retained-restoration
#10
JOURNAL ARTICLE
Lady Arbelaez-Bonozo, Serafín Maza-Solano, María Baus-Domínguez, Raquel Gómez-Díaz, Gonzalo Ruiz-de-Leon-Pacheco, Daniel Torres-Lagares, María-Angeles Serrera-Figallo
Background: The objective of this study was to evaluate the pain and inflammatory response in soft tissues using healing and prosthetic abutments of different diameters and lengths. Methods: The study population was rehabilitated with Astra Tech EV single implants (Dentsply Sirona, Atlantis, Dentsply Sirona S.A., Barcelona, Spain) of 4.2 and 4.8 millimetres in diameter in the upper and lower maxilla and loaded with custom abutments digitally designed using Dentsply Sirona's Virtual Atlantis Design software (Atlantis WebOrder, Dentsply Sirona S...
March 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541845/implementation-of-the-care-bundle-for-the-management-of-chronic-obstructive-pulmonary-disease-with-without-heart-failure
#11
REVIEW
Andrea Bianco, Marco Canepa, Giosuè Angelo Catapano, Maurizio Marvisi, Fabrizio Oliva, Andrea Passantino, Riccardo Sarzani, Paolo Tarsia, Antonio Giovanni Versace
Chronic obstructive pulmonary disease (COPD) is often part of a more complex cardiopulmonary disease, especially in older patients. The differential diagnosis of the acute exacerbation of COPD and/or heart failure (HF) in emergency settings is challenging due to their frequent coexistence and symptom overlap. Both conditions have a detrimental impact on each other's prognosis, leading to increased mortality rates. The timely diagnosis and treatment of COPD and coexisting factors like left ventricular overload or HF in inpatient and outpatient care can improve prognosis, quality of life, and long-term outcomes, helping to avoid exacerbations and hospitalization, which increase future exacerbation risk...
March 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541816/simulation-and-training-in-robot-assisted-urological-surgery-from-model-to-patient
#12
REVIEW
Flavia Proietti, Rocco Simone Flammia, Leslie Claire Licari, Eugenio Bologna, Umberto Anceschi, Maria Consiglia Ferriero, Gabriele Tuderti, Riccardo Mastroianni, Aldo Brassetti, Giuseppe Simone, Costantino Leonardo
(1) Background: Simulation-based training has revolutionized surgical education, providing a solution to the changing demands of surgical training and performance. The increasing demand for standardized training in robotic surgery has accelerated the adoption of simulation-based training as a necessary component of modern surgical education. This study examines the existing literature on training approaches employed in robot-assisted urological surgery; (2) Methods: The authors conducted a standardized search of online databases...
March 10, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541762/the-clinical-utility-of-lower-extremity-dual-energy-ct-angiography-in-the-detection-of-bone-marrow-edema-in-diabetic-patients-with-peripheral-artery-disease
#13
JOURNAL ARTICLE
Chiara Floridi, Laura Maria Cacioppa, Tommaso Valeri, Nicolo Rossini, Marzia Rosati, Vincenzo Vento, Alessandro Felicioli, Marco Macchini, Roberto Candelari, Marina Carotti, Andrea Giovagnoni
(1) Background : Type 2 diabetes is a major cause of incidences and the progression of peripheral artery disease (PAD). Bone marrow edema (BME) is an important finding suggestive of underlying bone inflammation in non-traumatic diabetic patients with PAD. Our aim was to evaluate the presence, severity, and clinical implications of BME detected by virtual non-calcium application (VNCa) of dual-energy CT angiography (DE-CTA). (2) Methods : A consecutive series of 76 diabetic patients (55 men; mean age 71.6 ± 11...
March 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541755/economic-cost-of-rehabilitation-with-robotic-and-virtual-reality-systems-in-people-with-neurological-disorders-a-systematic-review
#14
REVIEW
Roberto Cano-de-la-Cuerda, Aitor Blázquez-Fernández, Selena Marcos-Antón, Patricia Sánchez-Herrera-Baeza, Pilar Fernández-González, Susana Collado-Vázquez, Carmen Jiménez-Antona, Sofía Laguarta-Val
Background : The prevalence of neurological disorders is increasing worldwide. In recent decades, the conventional rehabilitation for people with neurological disorders has been often reinforced with the use of technological devices (robots and virtual reality). The aim of this systematic review was to identify the evidence on the economic cost of rehabilitation with robotic and virtual reality devices for people with neurological disorders through a review of the scientific publications over the last 15 years...
March 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541130/comparative-analysis-of-psychophysiological-responses-in-fibromyalgia-patients-evaluating-neuromodulation-alone-neuromodulation-combined-with-virtual-reality-and-exercise-interventions
#15
JOURNAL ARTICLE
Alejandro Rubio-Zarapuz, María Dolores Apolo-Arenas, Pablo Tomas-Carus, José Francisco Tornero-Aguilera, Vicente Javier Clemente-Suárez, Jose A Parraca
BACKGROUND AND OBJECTIVES: Fibromyalgia, a chronic condition, manifests as widespread musculoskeletal pain, fatigue, sleep disturbances, autonomic and cognitive dysfunction, hypersensitivity to stimuli, and various somatic and psychiatric symptoms. This study, a controlled and randomized experiment, aimed to evaluate and compare the immediate effects of different treatments on fibromyalgia patients. MATERIALS AND METHODS: The treatments included the EXOPULSE Mollii suit, a combination of the EXOPULSE Mollii suit with a virtual reality (VR) protocol, and a physical exercise regimen...
February 27, 2024: Medicina
https://read.qxmd.com/read/38540555/mood-lifters-for-graduate-students-and-young-adults-a-mixed-methods-investigation-into-mechanisms-of-change-in-online-group-therapy
#16
JOURNAL ARTICLE
Elena L Pokowitz, Neema Prakash, Dennis Planaj, Sophia Oprandi, Patricia J Deldin
Mood Lifters (ML) is a dimensional, group-based, peer-led mental health program that has shown efficacy in mitigating psychopathology and promoting wellness within a variety of populations. There is not yet evidence for mechanism(s) driving these changes. Qualitative data exploring the lived experiences of participants may be a unique way to develop hypotheses about the potential mechanisms driving change. The current study used qualitative and quantitative data from the ML for Graduate Students (ML-GS) and Young Adults (ML-YA) studies to generate hypotheses regarding potential mechanisms of changes experienced in ML...
March 20, 2024: Behavioral Sciences
https://read.qxmd.com/read/38540346/full-length-transcriptome-sequencing-and-rna-seq-analysis-offer-insights-into-terpenoid-biosynthesis-in-blumea-balsamifera-l-dc
#17
JOURNAL ARTICLE
Zhigang Ju, Lin Liang, Yaqiang Zheng, Hongxi Shi, Wenxuan Zhao, Wei Sun, Yuxin Pang
Blumea balsamifera (L.) DC., an important economic and medicinal herb, has a long history of being used as a traditional Chinese medicine. Its leaves have always been used as a raw material for the extraction of essential oils, comprising large amounts of terpenoids, which have good therapeutic effects on many diseases, such as eczema, bacterial infection, and hypertension. However, the genetic basis of terpenoid biosynthesis in this plant is virtually unknown on account of the lack of genomic data. Here, a combination of next-generation sequencing (NGS) and full-length transcriptome sequencing was applied to identify genes involved in terpenoid biosynthesis at five developmental stages...
February 24, 2024: Genes
https://read.qxmd.com/read/38539218/choosing-and-accessing-covid-19-treatment-options-a-qualitative-study-with-patients-caregivers-and-health-care-providers-in-lebanon
#18
JOURNAL ARTICLE
Reem Hoteit, Aya Hassoun, Elie Bou Sanayeh, Marie Christelle Saade, Gladys Honein-AbouHaidar, Elie A Akl
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has strained healthcare systems globally, particularly in terms of access to medicines. Lebanon has been greatly affected by the pandemic, having faced concomitant financial and economic crises. The objective of the study was to understand the experiences of patients with COVID-19 in Lebanon, as well as those of their families, and healthcare providers, with regards to their treatment decisions and accessibility to COVID-19 medicines...
March 27, 2024: Health Research Policy and Systems
https://read.qxmd.com/read/38538815/optimising-total-knee-replacement-imaging-a-novel-3d-printed-pet-ct-anthropomorphic-phantom-for-metal-artefact-simulation
#19
JOURNAL ARTICLE
Rajeh Assiri, Karen Knapp, Jon Fulford, Junning Chen
PURPOSE: Arthroplasty phantoms, including total knee replacement (TKR) phantoms, have been frequently used to test metal artefact reduction methods applied to positron emission tomography/computed tomography (PET/CT) images. These phantoms generally simulate either simple anatomical features or simple activity distribution around the metal inserts in the PET/CT scans. 3D printing has been used recently to fabricate fillable anthropomorphic phantoms that accurately simulate volume and geometry...
March 28, 2024: EJNMMI Physics
https://read.qxmd.com/read/38537564/evaluation-of-models-of-sequestration-flow-in-coronary-arteries-physiology-versus-anatomy
#20
JOURNAL ARTICLE
Daniel J Taylor, Harry Saxton, Ian Halliday, Tom Newman, Jeroen Feher, Rebecca Gosling, Andrew J Narracott, Denise van Kemenade, Marcel Van't Veer, Pim A L Tonino, Michel Rochette, D Rodney Hose, Julian P Gunn, Paul D Morris
BACKGROUND: Myocardial ischaemia results from insufficient coronary blood flow. Computed virtual fractional flow reserve (vFFR) allows quantification of proportional flow loss without the need for invasive pressure-wire testing. In the current study, we describe a novel, conductivity model of side branch flow, referred to as 'leak'. This leak model is a function of taper and local pressure, the latter of which may change radically when focal disease is present. This builds upon previous techniques, which either ignore side branch flow, or rely purely on anatomical factors...
March 18, 2024: Computers in Biology and Medicine
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