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https://www.readbyqxmd.com/read/29336344/-the-urologist-of-the-future-and-new-technologies
#1
Francois Peinado, Atanasio Fernández, Fernando Teba, Guillermo Celada, Marco Antonio Acosta
The last 25 years have brought about revolutionary changes for medicine and in particular for urology: internet was only in its infancy, medical records were written on paper, searches for medical information were done in the hospital library, medical articles were photocopied and our relationship with patients only existed face to face. Social networks had not yet appeared and even Google did not exist. Just imagine what might happen during the next 25 years, we're going to see even more radical changes. The urologist of the future is going to see the arrival of artificial intelligence, collaborative medicine, telemedicine, machine learning, the Internet of Things and personalized robotics; in the meantime, social media will continue to transform the interaction between physician and patient...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29329463/ginsenoside-rh1-a-systematic-review-of-its-pharmacological-properties
#2
Dao Ngoc Hien Tam, Duy Hieu Truong, Thi Thanh Hoa Nguyen, Le Nhat Quynh, Linh Tran, Hong Duong Nguyen, Bahaa Eldin Shamandy, Thi Minh Huong Le, Dang Khoa Tran, Dina Sayed, Van Vinh Vu, Shusaku Mizukami, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29328995/filter-base-a-web-accessible-chemical-database-for-small-compound-libraries
#3
Baban S Kolte, Sanjay R Londhe, Bhushan R Solanki, Rajesh N Gacche, Rohan J Meshram
Finding novel chemical agents for targeting disease associated drug targets often requires screening of large number of new chemical libraries. In silico methods are generally implemented at initial stages for virtual screening. Filtering of such compound libraries on physicochemical and substructure ground is done to ensure elimination of compounds with undesired chemical properties. Filtering procedure, is redundant, time consuming and requires efficient bioinformatics/computer manpower along with high end software involving huge capital investment that forms a major obstacle in drug discovery projects in academic setup...
January 6, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29324679/antibacterial-evaluation-and-virtual-screening-of-new-thiazolyl-triazole-schiff-bases-as-potential-dna-gyrase-inhibitors
#4
Cristina Nastasă, Dan C Vodnar, Ioana Ionuţ, Anca Stana, Daniela Benedec, Radu Tamaian, Ovidiu Oniga, Brînduşa Tiperciuc
The global spread of bacterial resistance to drugs used in therapy requires new potent and safe antimicrobial agents. DNA gyrases represent important targets in drug discovery. Schiff bases, thiazole, and triazole derivatives are considered key scaffolds in medicinal chemistry. Fifteen thiazolyl-triazole Schiff bases were evaluated for their antibacterial activity, measuring the growth inhibition zone diameter, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC), against Gram-positive (Staphylococcus aureus, Listeria monocytogenes) and Gram-negative (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa) bacteria...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29322551/improving-parallel-imaging-by-jointly-reconstructing-multi-contrast-data
#5
Berkin Bilgic, Tae Hyung Kim, Congyu Liao, Mary Kate Manhard, Lawrence L Wald, Justin P Haldar, Kawin Setsompop
PURPOSE: To develop parallel imaging techniques that simultaneously exploit coil sensitivity encoding, image phase prior information, similarities across multiple images, and complementary k-space sampling for highly accelerated data acquisition. METHODS: We introduce joint virtual coil (JVC)-generalized autocalibrating partially parallel acquisitions (GRAPPA) to jointly reconstruct data acquired with different contrast preparations, and show its application in 2D, 3D, and simultaneous multi-slice (SMS) acquisitions...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29288071/design-and-synthesis-of-a-potent-highly-selective-orally-bioavailable-retinoic-acid-receptor-alpha-agonist
#6
Earl Clarke, Christopher I Jarvis, Maria B Goncalves, S Barret Kalindjian, David R Adams, Jane T Brown, Jason J Shiers, David M A Taddei, Elodie Ravier, Stephanie Barlow, Iain Miller, Vanessa Smith, Alan D Borthwick, Jonathan P T Corcoran
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5, which has good selectivity over the RARβ, and RARγ receptors. Analysis of the medicinal chemistry parameters of the 3,5-substituents of derivatives of template 5 enabled us to design a class of drug-like molecules with lower intrinsic clearance and higher oral bioavailability which led to the novel RARα agonist 4-(3-chloro-4-ethoxy-5-isopropoxybenzamido)-2-methylbenzoic acid 56 that has high RARα potency and excellent selectivity versus RARβ (2 orders of magnitude) and RARγ (4 orders of magnitude) at both the human and mouse RAR receptors with improved drug-like properties...
December 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29285786/an-industrial-design-solution-for-integrating-nmr-magnetic-field-sensors-into-an-mri-scanner
#7
Michael Kennedy, Yoojin Lee, Zoltan Nagy
PURPOSE: Neuroimaging research relies on the skills of increasingly multidisciplinary individuals and often requires the installation and use of additional home-built or third-party equipment. The purpose of the present work was the safe, ergonomic, durable, and aesthetically pleasing installation of magnetic field monitoring equipment into a scanner, while keeping the setup compatible with standard operating procedures. METHODS: An extensive set of steps was required to design a 3D printed solution to install a magnetic field camera into the eight-channel head coil of a 3T MRI scanner...
December 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29285753/biobanks-in-the-era-of-digital-medicine
#8
Gunnar Jacobs, Andreas Wolf, Michael Krawczak, Wolfgang Lieb
Digitalization is currently permeating virtually all sectors of modern societies, including biomedical research and medical care. At the same time, biobanks engaged in the long-term storage of biological samples that are fit for purpose have become key drivers in both fields. The present article highlights some of the challenges and opportunities that biobanking is facing in the current proverbial "era of digitalization."
December 29, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29285341/simulating-a-virtual-population-s-sensitivity-to-salt-and-uninephrectomy
#9
John S Clemmer, Robert L Hester, W Andrew Pruett
Salt sensitivity, with or without concomitant hypertension, is associated with increased mortality. Reduced functional renal mass plays an important role in causing salt-sensitive hypertension for many individuals. Factors that are important in the condition of decreased renal mass and how they affect blood pressure (BP) or salt sensitivity are unclear. We used HumMod, an integrative mathematical model of human physiology, to create a heterogeneous population of 1000 virtual patients by randomly varying physiological parameters...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29279686/abutment-misfit-in-implant-supported-prostheses-manufactured-by-casting-technique-an-integrative-review
#10
REVIEW
Lorena M S Pereira, Mariane B Sordi, Ricardo S Magini, Antônio R Calazans Duarte, Júlio C M Souza
The aim of this study was to perform an integrative review of the literature on the clinically usual prosthesis-abutment misfit over implant-supported structures manufactured by conventional casting technique. The present integrative review used the PRISMA methodology. A bibliographical search was conducted on the following electronic databases: MEDLINE/PubMed (National Library of Medicine), Scopus (Elsevier), ScienceDirect (Elsevier), Web of Science (Thomson Reuters Scientific), Latin American and Caribbean Center on Health Sciences Information (BIREME), and Virtual Health Library (BVS)...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29278455/genetic-diagnosis-of-down-syndrome-in-an-underserved-community
#11
Andrew K Sobering, Joshua B Stevens, Janice L Smith, Beverly Nelson, Tyhiesia Donald, Sarah H Elsea
It is a matter of course that in high-income countries, infants born with features suggestive of Down syndrome (DS) are offered genetic testing for confirmation of a clinical diagnosis. Benefits of a definitive diagnosis include an end to the diagnostic odyssey, informed prognosis, opportunities for caregiver support, inclusion to social support networks, and more meaningful genetic counseling. The healthcare experience for families of children born with DS in low- and middle-income nations is in stark contrast with such a level of care...
December 26, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29277662/nf-%C3%AE%C2%BAb-in-the-crosshairs-rethinking-an-old-riddle
#12
Jason Bennett, Daria Capece, Federica Begalli, Daniela Verzella, Daniel D'Andrea, Laura Tornatore, Guido Franzoso
Constitutive NF-κB signalling has been implicated in the pathogenesis of most human malignancies and virtually all non-malignant pathologies. Accordingly, the NF-κB pathway has been aggressively pursued as an attractive therapeutic target for drug discovery. However, the severe on-target toxicities associated with systemic NF-κB inhibition have thus far precluded the development of a clinically useful, NF-κB-targeting medicine as a way to treat patients with either oncological or non-oncological diseases...
December 22, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29275549/-research-progress-of-sudden-cardiac-death-in-forensic-medicine
#13
REVIEW
D Zheng, K Yin, J J Zheng, N Zhou, Y Liu, X Fu, J D Cheng
Sudden death (SD) is a special kind of death owing to disease, which severely threatening the lives of community population. As the most common type of SD, sudden cardiac death (SCD) has always been a crucial content of identification and research in forensic pathology. This article reviews the research progress from the aspects of epidemiology, morphology, molecular pathology and virtual anatomy of SCD in forensic medicine, so as to provide a reference for the morphological identification, determination of cause of death, and integrated control of this kind of SD...
October 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29260271/reconstruction-of-mandibular-contour-using-individualized-high-density-porous-polyethylene-medpor%C3%A2-implants-under-the-guidance-of-virtual-surgical-planning-and-3d-printed-surgical-templates
#14
Yu Wang, Yiqun Zhang, Zhen Zhang, Xiang Li, Jianwei Pan, Jihua Li
BACKGROUND: The mandibular contour plays a significant role in the beautiful and youthful look but the reconstruction remains a challenging problem. The objective of this study was to evaluate the use of individualized high-density porous polyethylene (Medpor®) implants for comprehensive reconstruction of mandibular contour with the aid of computer-aided design/computer-aided manufacturing (CAD/CAM). METHODS: From 2010 to 2014, 12 patients with mandibular contour deformities were enrolled in our retrospective study...
December 19, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29249974/computational-modeling-in-liver-surgery
#15
REVIEW
Bruno Christ, Uta Dahmen, Karl-Heinz Herrmann, Matthias König, Jürgen R Reichenbach, Tim Ricken, Jana Schleicher, Lars Ole Schwen, Sebastian Vlaic, Navina Waschinsky
The need for extended liver resection is increasing due to the growing incidence of liver tumors in aging societies. Individualized surgical planning is the key for identifying the optimal resection strategy and to minimize the risk of postoperative liver failure and tumor recurrence. Current computational tools provide virtual planning of liver resection by taking into account the spatial relationship between the tumor and the hepatic vascular trees, as well as the size of the future liver remnant. However, size and function of the liver are not necessarily equivalent...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29237222/-surgery-during-pregnancy-regulations-and-requirements
#16
Frauke Fritze-Büttner, Ronny Dittmar, Maya Niethard
Due to the marked increase in the numbers of women in medicine, professional and political discussions on equality among doctors are gaining increasing attention. One such issue is "operating during pregnancy". As a result of existing legislation and federal regulations, it has been virtually impossible for pregnant surgeons to continue their surgical work. After approval by the Federal Council or Bundesrat, the revised Maternity Protection Act will come into force on 01.01.2018. It will thereafter be easier for surgeons to operate during pregnancy...
December 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29233854/efficacy-of-educational-video-game-versus-traditional-educational-apps-at-improving-physician-decision-making-in-trauma-triage-randomized-controlled-trial
#17
Deepika Mohan, Coreen Farris, Baruch Fischhoff, Matthew R Rosengart, Derek C Angus, Donald M Yealy, David J Wallace, Amber E Barnato
OBJECTIVE: To determine whether a behavioral intervention delivered through a video game can improve the appropriateness of trauma triage decisions in the emergency department of non-trauma centers. DESIGN: Randomized clinical trial. SETTING: Online intervention in national sample of emergency medicine physicians who make triage decisions at US hospitals. PARTICIPANTS: 368 emergency medicine physicians primarily working at non-trauma centers...
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29226274/virtual-dissection-by-ultrasound-probe-handling-in-the-first-year-of-medical-education
#18
Graziano Serrao, Massimo Tassoni, Alberto M Magenta-Biasina, Antonio Giuseppe Mantero, Antonino Previtera, Michela Crisitna Turci, Elia Mario Biganzoli, Emanuela A M Bertolini
Objectives: The aim of the present study was to assess the educational plan of first-year students of medicine by analyzing their scores in ultrasound body scanning. Methods: Since 2009, the San Paolo Medical School (Milan, Italy) has vertically integrated the study of anatomy with ultrasound-assisted virtual body dissection. Three modules were supplied: musculoskeletal system, heart and abdomen pelvis. 653 first-year students were trained. The students alternated as mutual model and operator...
September 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/29222075/examining-tensions-that-affect-the-evaluation-of-technology-in-health-care-considerations-for-system-decision-makers-from-the-perspective-of-industry-and-evaluators
#19
Laura Desveaux, James Shaw, Ross Wallace, Onil Bhattacharyya, R Sacha Bhatia, Trevor Jamieson
Virtual technologies have the potential to mitigate a range of challenges for health care systems. Despite the widespread use of mobile devices in everyday life, they currently have a limited role in health service delivery and clinical care. Efforts to integrate the fast-paced consumer technology market with health care delivery exposes tensions among patients, providers, vendors, evaluators, and system decision makers. This paper explores the key tensions between the high bar for evidence prior to market approval that guides health care regulatory decisions and the "fail fast" reality of the technology industry...
December 8, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29205048/electroconvulsive-therapy-stimulus-titration-not-all-it-seems
#20
Stephen J Rosenman
OBJECTIVE: To examine the provenance and implications of seizure threshold titration in electroconvulsive therapy. BACKGROUND: Titration of seizure threshold has become a virtual standard for electroconvulsive therapy. It is justified as individualisation and optimisation of the balance between efficacy and unwanted effects. RESULT: Present day threshold estimation is significantly different from the 1960 studies of Cronholm and Ottosson that are its usual justification...
December 1, 2017: Australian and New Zealand Journal of Psychiatry
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