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https://www.readbyqxmd.com/read/27884454/-management-of-adverse-effects-related-to-human-immunoglobulin-therapy-recommendations-for-clinical-practice
#1
I Marie, P Chérin, M Michallet, E Pelus, J Dantal, J-C Crave, J-C Delain, J-F Viallard
Both intravenous and subcutaneous immunoglobulins are therapeutic modalities approved in various conditions, including primary and secondary immune deficiencies and autoimmune disorders. To date, immunoglobulins have more often been considered as a safe medication, with minor adverse effects such as hypertension, fever and chills, nausea, myalgia or headache. However, with the wider use of immunoglobulins in the treatment of autoimmune diseases, severe side effects have also been reported to occur in immunoglobulin-treated patients, especially anaphylaxis, aseptic meningitis, acute renal impairment, thrombotic events as well as haematological manifestations...
November 21, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27828810/community-acquired-bacterial-meningitis
#2
Joost M Costerus, Matthijs C Brouwer, Merijn W Bijlsma, Diederik van de Beek
PURPOSE OF REVIEW: Bacterial meningitis is a medical emergency and is associated with a high disease burden. We reviewed recent progress in the management of patients with community-acquired bacterial meningitis. RECENT FINDINGS: The worldwide burden of disease of bacterial meningitis remains high, despite the decreasing incidence following introduction of routine vaccination campaigns. Delay in diagnosis and treatment remain major concerns in the management of acute bacterial meningitis...
November 8, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27760140/estimated-prevalence-of-cryptococcus-antigenemia-crag-among-hiv-infected-adults-with-advanced-immunosuppression-in-namibia-justifies-routine-screening-and-preemptive-treatment
#3
Souleymane Sawadogo, Boniface Makumbi, Anne Purfield, Christophine Ndjavera, Gram Mutandi, Andrew Maher, Francina Kaindjee-Tjituka, Jonathan E Kaplan, Benjamin J Park, David W Lowrance
BACKGROUND: Cryptococcal meningitis is common and associated with high mortality among HIV infected persons. The World Health Organization recommends that routine Cryptococcal antigen (CrAg) screening in ART-naïve adults with a CD4+ count <100 cells/μL followed by pre-emptive antifungal therapy for CrAg-positive patients be considered where CrAg prevalence is ≥3%. The prevalence of CrAg among HIV adults in Namibia is unknown. We estimated CrAg prevalence among HIV-infected adults receiving care in Namibia for the purpose of informing routine screening strategies...
2016: PloS One
https://www.readbyqxmd.com/read/27751821/evaluation-and-management-of-the-swollen-optic%C3%A2-disk-in-cryptococcal-meningitis
#4
REVIEW
Mohammed Rigi, Khurrum Khan, Stacy V Smith, Ayman O Suleiman, Andrew G Lee
Cryptococcal meningitis is the most common and severe form of cryptococcal infection. In addition to infiltrative and inflammatory mechanisms, intracranial hypertension commonly complicates cryptococcal meningitis and may cause significant visual and neurological morbidity and mortality. The mainstays of treatment for cryptococcal meningitis include standard antifungal therapy, management of intracranial hypertension, and treatment of underlying immunosuppressive conditions. Early and aggressive management of intracranial hypertension in accordance with established guidelines reduces the risk of long-term visual and neurological complications and death...
October 15, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27720091/ongoing-cases-of-early-onset-group-b-streptococcal-disease-in-the-era-of-screening-and-prophylaxis
#5
Vanessa Poliquin, Elissa Cohen, Philippe Guillaume Poliquin, Carol Schneider, Savas Menticoglou
OBJECTIVE: We reviewed cases of group B Streptococcus (GBS) sepsis in term infants at our institution to identify areas for potential prevention. METHODS: We identified cases by searching our institution's microbiology databases for all positive GBS blood and cerebrospinal fluid cultures taken from infants between 2008 and 2013. Patients were included if the timing of the positive culture met the criteria for early-onset GBS disease (age 7 days or under). Charts that met inclusion criteria were abstracted for details related to antepartum screening, intrapartum care, and postpartum outcome...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27680224/a-case-of-cefepime-encephalopathy-being-difficult-to-distinguish-from-non-convulsive-status-epilepticus-during-the-treatment-of-bacterial-meningitis
#6
Yusuke Toda, Mineo Yamazaki, Tomohiro Ota, Yosuke Fujisawa, Kazumi Kimura
A 64-year-old man with fever, appetite loss, and pain in the back of the neck visited our hospital. We diagnosed him as having bacterial meningitis because of pleocytosis of the cerebrospinal fluid, and started treatment with antibiotics. Multiple cerebral infarcts were found on brain MRI. We suspected that the origin of the bacterial meningitis was infective endocarditis, and administered Cefepime and Gentamicin according to the guidelines for treatment of infective endocarditis. Three days later, he became drowsy and had myoclonus and flapping of the extremities...
September 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27670683/definition-and-management-of-varicella-zoster-virus-associated-meningoradiculitis-a-case-report
#7
Vincent Luisier, Lalensia Weber, Daniel Fishman, Gérard Praz, Joseph-André Ghika, Didier Genoud, Joelle Nsimire Chabwine
BACKGROUND: The varicella zoster virus affects the central or peripheral nervous systems upon reactivation, especially when cell-mediated immunity is impaired. Among varicella zoster virus-related neurological syndromes, meningoradiculitis is an ill-defined condition for which clear management guidelines are still lacking. Zoster paresis is usually considered to be a varicella zoster virus-peripheral nervous system complication and treated with oral antiviral therapy. Yet in the literature, the few reported cases of herpes zoster with mild cerebral spinal fluid inflammation were all considered meningoradiculitis and treated using intravenous antiviral drugs, despite absence of systemic signs of meningitis...
September 26, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27658382/development-and-performance-evaluation-of-a-recombinase-polymerase-amplification-assay-for-the-rapid-detection-of-group-b-streptococcus
#8
Christina Clarke, Louise O'Connor, Heather Carré-Skinner, Olaf Piepenburg, Terry J Smith
BACKGROUND: Despite the implementation of prevention guidelines, group B Streptococcal (GBS) infection remains a leading cause of sepsis, pneumonia, and meningitis, resulting in significant neonatal morbidity and mortality. Preventive approaches that identify women at risk of transmitting GBS have reduced the incidence of neonatal GBS disease, and dramatically decreased the associated mortality rates. However, there is an on-going requirement for a near-patient diagnostic test for GBS that can be carried out at the time of delivery, ideally in the labour ward setting, particularly for women of unknown GBS colonisation status at the time of delivery...
2016: BMC Microbiology
https://www.readbyqxmd.com/read/27607912/repeated-therapeutic-lumbar-punctures-in-cryptococcal-meningitis-necessity-and-or-opportunity
#9
Christina C Chang, John R Perfect
PURPOSE OF REVIEW: Overall, 50-70% of patients with cryptococcal meningitis have raised intracranial pressure (ICP). Multiple international treatment guidelines recommend repeated therapeutic lumbar punctures as adjunctive management. Here, we review the recent evidence for the role of repeated lumbar punctures on clinical outcome in cryptococcal meningitis and also review the increasing body of data utilizing these repeated cerebrospinal fluid (CSF) samples as a window into understanding immunopathogenesis of cryptococcal meningitis...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27581996/six-months-therapy-for-tuberculous-meningitis
#10
Sophie Jullien, Hannah Ryan, Manish Modi, Rohit Bhatia
BACKGROUND: Tuberculous meningitis (TBM) is the main form of tuberculosis that affects the central nervous system and is associated with high rates of death and disability. Most international guidelines recommend longer antituberculous treatment (ATT) regimens for TBM than for pulmonary tuberculosis disease to prevent relapse. However, longer regimens are associated with poor adherence, which could contribute to increased relapse, development of drug resistance, and increased costs to patients and healthcare systems...
September 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27491687/neonatal-infections-case-definition-and-guidelines-for-data-collection-analysis-and-presentation-of-immunisation-safety-data
#11
Stefania Vergnano, Jim Buttery, Ben Cailes, Ravichandran Chandrasekaran, Elena Chiappini, Ebiere Clark, Clare Cutland, Solange Dourado de Andrade, Alejandra Esteves-Jaramillo, Javier Ruiz Guinazu, Chrissie Jones, Beate Kampmann, Jay King, Sonali Kochhar, Noni Macdonald, Alexandra Mangili, Reinaldo de Menezes Martins, César Velasco Muñoz, Michael Padula, Flor M Muñoz, James Oleske, Melvin Sanicas, Elizabeth Schlaudecker, Hans Spiegel, Maja Subelj, Lakshmi Sukumaran, Beckie N Tagbo, Karina A Top, Dat Tran, Paul T Heath
Maternal vaccination is an important area of research and requires appropriate and internationally comparable definitions and safety standards. The GAIA group, part of the Brighton Collaboration was created with the mandate of proposing standardised definitions applicable to maternal vaccine research. This study proposes international definitions for neonatal infections. The neonatal infections GAIA working group performed a literature review using Medline, EMBASE and the Cochrane collaboration and collected definitions in use in neonatal and public health networks...
December 1, 2016: Vaccine
https://www.readbyqxmd.com/read/27484018/impact-of-an-evidence-based-guideline-on-the-management-of-community-acquired-bacterial-meningitis-a-prospective-cohort-study
#12
J M Costerus, M C Brouwer, M W Bijlsma, M W Tanck, A van der Ende, D van de Beek
OBJECTIVES: To study the impact of an evidence-based guideline on the management of community-acquired bacterial meningitis. METHODS: We performed an interrupted time series analysis in a prospective nationwide cohort study from 2006 to 2015. The guideline stresses the importance of cranial imaging before lumbar puncture (LP) in selected patients based on clinical criteria, and early treatment with amoxicillin and a third-generation cephalosporin for adults with suspected community-acquired bacterial meningitis...
November 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27436468/successful-treatment-of-postoperative-multidrug-resistant-acinetobacter-baumannii-meningitis-by-tigecycline
#13
Ikbel Kooli, Hajer Ben Brahim, Mohamed Kilani, Chokri Gannouni, Abir Aouam, Adnene Toumi, Chawki Loussaief, Mohamed Nejib Hattab, Mohamed Chakroun
Tigecycline is a broad-spectrum antibiotic with activity against multidrug-resistant (MDR) bacteria. It has limited indications. Studies are necessary to elaborate new guidelines. Here we report a case of postoperative MDR Acinetobacter baumannii meningitis treated by tigecycline combined with colimycin for 21 days. The treatment was well tolerated with a favourable outcome. In conclusion, tigecycline was shown to be effective in a case of MDR A. baumannii meningitis.
June 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27408520/investigation-of-the-selection-and-timing-of-pharmacological-therapy-in-community-acquired-bacterial-meningitis
#14
Jared Sheley, Dave Willman, Julie Downen, Scott Bergman
BACKGROUND: Bacterial meningitis is responsible for significant morbidity and mortality, but early appropriate therapy is expected to improve outcomes. National treatment guidelines were published in 2004, but no assessment of their utilization in the U.S. has been reported. OBJECTIVES: To measure adherence to meningitis treatment guidelines and describe patient outcomes in relation to recommended antibiotic and dexamethasone use. METHODS: Retrospective chart reviews were performed on patients with bacterial meningitis who presented to emergency departments at two community teaching hospitals...
July 2016: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/27385362/group-b-streptococcal-immunisation-of-pregnant-women-for-the-prevention-of-early-and-late-onset-group-b-streptococcal-infection-of-the-neonate-as-well-as-adult-disease
#15
Anna L Kenchington, Ronald F Lamont
INTRODUCTION: Early onset neonatal Group B streptococcal disease is preventable. Intrapartum antibiotic prophylaxis has resulted in a significant reduction in neonatal mortality and morbidity. National guidelines for the selection of women eligible for intrapartum antibiotic prophylaxis, whether screening-based or risk-based, differ according to the local burden of disease. Despite the introduction of intrapartum antibiotic prophylaxis, there remains a significant burden of disease, which can be resolved by better adherence to guidelines, rapid identification of maternal colonization or in the future, vaccination...
July 6, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27348896/-lyme-disease-clinical-manifestations-and-treatment
#16
Ingo Stock
Lyme disease (Lyme borreliosis) is a systemic infectious disease that can present in a variety of clinical manifestations. The disease is caused by a group of spirochaetes--Borrelia burgdorferi sensu lato or Lyme borrelia--that are transmitted to humans by the bite of Ixodes ticks. Lyme disease is the most common arthropode-borne infectious disease in many European countries including Germany. Early localized infection is typically manifested by an erythema migrans skin lesion, in rarer cases as a borrelial lymphocytoma...
May 2016: Medizinische Monatsschrift Für Pharmazeuten
https://www.readbyqxmd.com/read/27315003/-injury-by-skull-osteolytic-secundary-syphilis
#17
Lucas Alessandro, Julieta Piar Camporro, Naomi Arakaki, Nora Orellana, Claudia Andrea Mora
Bone involvement of syphilis can be observed in tertiary and congenital syphilis. It is infrequent during the secondary stage. The skull is the most affected bone in secondary syphilis, and its most frequent form of presentation is proliferative osteitis. If the skull is affected, headache is usual and can be as intense as in meningitis. Osteolyitic lesions may be seen in complimentary imaging studies, with a moth eaten aspect. These lesions raise concern over a number of differential diagnoses, among which are infectious, inflammatory and neoplastic diseases...
April 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27306100/tuberculous-meningitis-is-a-major-cause-of-mortality-and-morbidity-in-adults-with-central-nervous-system-infections-in-kota-kinabalu-sabah-malaysia-an-observational-study
#18
Heng Gee Lee, Timothy William, Jayaram Menon, Anna P Ralph, Eng Eong Ooi, Yan'an Hou, October Sessions, Tsin Wen Yeo
BACKGROUND: Central nervous system (CNS) infections are a significant contributor to morbidity and mortality globally. However, most published studies have been conducted in developed countries where the epidemiology and aetiology differ significantly from less developed areas. Additionally, there may be regional differences due to variation in the socio-economic levels, public health services and vaccination policies. Currently, no prospective studies have been conducted in Sabah, East Malaysia to define the epidemiology and aetiology of CNS infections...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27241087/usefulness-of-embolization-for-iatrogenic-dural-arteriovenous-fistula-associated-with-recurrent-chronic-subdural-hematoma-a-case-report-and-literature-review
#19
Tushit Mewada, Tomotaka Ohshima, Taiki Yamamoto, Shunsaku Goto, Yoko Kato
BACKGROUND: Refractory chronic subdural hematomas due to iatrogenic dural arteriovenous fistulas (dAVFs) are difficult to treat. We report our experience and propose a guideline on basis of a literature review for the usefulness of embolization of middle meningeal artery (MMA) for the treatment of the same. CASE DESCRIPTION: We report a case with right hemiparesis and aphasia 1 month after a fall from a bicycle. Computed tomography scan of the head showed left chronic subdural hematoma, which was evacuated by burr-hole drainage...
August 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27167986/efficacy-and-safety-of-trastuzumab-emtansine-t-dm1-in-patients-with-her2-positive-breast-cancer-with-brain-metastases
#20
William Jacot, Elvire Pons, Jean-Sébastien Frenel, Séverine Guiu, Christelle Levy, Pierre Etienne Heudel, Thomas Bachelot, Véronique D'Hondt, Amélie Darlix, Nelly Firmin, Gilles Romieu, Simon Thezenas, Florence Dalenc
Few data are currently available regarding the efficacy and safety of T-DM1 in breast cancer (BC) patients with unselected brain metastases (BM), since most clinical trials have excluded BM patients or have only included highly selected patients. HER2 + BC patients with BM treated with T-DM1 in 5 French centers were included in this retrospective study. Clinical management was performed according to the product guidelines. Efficacy was evaluated recording tumor response rates, progression-free (PFS) and overall survival, treatment compliance, and safety...
June 2016: Breast Cancer Research and Treatment
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