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https://www.readbyqxmd.com/read/29747285/-expert-consensus-on-the-diagnosis-and-treatment-of-cryptococcal-meningitis
#1
Z Y Liu, G Q Wang, L P Zhu, X J Lyu, Q Q Zhang, Y S Yu, Z H Zhou, Y B Liu, W P Cai, R Y Li, W H Zhang, F J Zhang, H Wu, Y C Xu, H Z Lu, T S Li
Cryptococcal meningitis is a common and refractory central nervous system infection, with high rates of mortality and disability. The experts of the Society of Infectious Diseases of Chinese Medical Association have reached this consensus after a thorough discussion. Based on the current situation of cryptococcal meningitis in China, the management of cryptococcal meningitis includes 6 aspects: introduction, microorganism identification, clinical manifestations and diagnosis, principles of antifungal therapy, treatment of refractory and recurrent meningitis, treatment of intracranial hypertension...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29742199/diagnostic-and-therapeutic-strategies-in-cryptococcosis-impact-on-outcome
#2
Timothée Boyer Chammard, Elvis Temfack, Olivier Lortholary, Alexandre Alanio
Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using "test and treat" screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29728084/group-b-streptococci-vaginal-colonization-and-drug-susceptibility-pattern-among-pregnant-women-attending-in-selected-public-antenatal-care-centers-in-addis-ababa-ethiopia
#3
Solomon Assefa, Kassu Desta, Tsehaynesh Lema
BACKGROUND: Group B Streptococcus (GBS) is the leading cause of septicemia, meningitis, and pneumonia in neonates. Maternal colonization with GBS is the principal risk factor for early-onset disease in infants. Group B Streptococcus is now an important cause of maternal and neonatal morbidity and mortality in many parts of the world. In Ethiopia, few studies have been done on GBS colonization among pregnant women. The aim of this study was to determine the prevalence of GBS colonization, antimicrobial susceptibility patterns and assess risk factors among pregnant women...
May 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29716663/organization-or-community-based-outbreak-responding-to-cases-of-meningitis-under-epidemiologic-uncertainty
#4
Tea Burmaz, Vittorio Selle, Vincenzo Baldo, Elena Savoia
Six cases of serogroup C invasive meningococcal disease were identified in Treviso district, Veneto region, Italy between December 13 and 15, 2007. The afflicted patients were found to have attended the same Latin-dance clubs on the same nights, and chemoprophylaxis was provided to potentially exposed individuals. Despite these efforts, 2 cases caused by the same meningococcal strain subsequently occurred in the same area, without any apparent epidemiological correlation to the initial cases. This may have resulted from a failure to neutralize the meningococcal carrier/s...
May 2, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29663539/cryptococcal-infections-over-a-15-year-period-at-a-tertiary-facility-impact-of-guideline-management
#5
Ian Gassiep, Joel Douglas, Theophilus I Emeto, Katherine Crawley, Elliott G Playford
BACKGROUND: Cryptococcosis is an invasive fungal infection caused primarily by Cryptococcus neoformans and Cryptococcus gattii species, presenting predominantly as meningoencephalitis. The aim of this study is to assess all cryptococcal infections managed at our facility from 2001-2015 to determine incidence, risk factors, and comparison of outcomes prior to and following introduction of the 2010 Infectious Disease Society of America (IDSA) guidelines. METHODS: Retrospective analysis of all patients diagnosed and treated for cryptococcal infection occurring between January 2001 and December 2015...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29582975/feasibility-of-endoscopic-endonasal-approach-for-clip-application-of-cerebral-aneurysms-a-systematic-review
#6
Jonathan A Forbes, Sophie D' Herbemont, Kurt R Lehner, Diego Pineda Martinez, Ignacio P Navarro-Chávez, Diego Mendez Rosito, Theodore H Schwartz
INTRODUCTION: While open, microsurgical clipping and endovascular coiling remain the gold standards for treatment of cerebral aneurysms, a growing number of aneurysms treated via endoscopic endonasal methods have been reported in the literature. The aim of this study was to conduct a systematic review of the literature to gain a more thorough appreciation of the potential benefits and drawbacks of the endoscopic endonasal strategy in this setting. EVIDENCE ACQUISITION: We performed a detailed systematic review of the medical literature on endoscopic endonasal skull base surgery for treatment of cerebral aneurysms utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29564346/kawasaki-disease-among-egyptian-children-a-case-series
#7
Tarek Hamed Attia, Saed M Morsy, Bashier A Hassan, Al Shymaa A Ali
Kawasaki disease is an acute vasculitis of early childhood. Its incidence varies among different ethnic groups with higher rates among Asians. In this case series, we presented four cases of Kawasaki disease with incomplete or atypical presentations in Egyptian children. Two cases presented with meningitis, which is not a criteria for the diagnosis of Kawasaki disease. The other two cases presented with pharyngitis and fever, which did not respond to antibiotics. The clinical criteria for diagnosis of Kawasaki disease were either incomplete or appeared sequentially...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29543582/progress-toward-the-global-control-of-neisseria-meningitidis-21st-century-vaccines-current-guidelines-and-challenges-for-future-vaccine-development
#8
A W Dretler, N G Rouphael, D S Stephens
The control of meningitis, meningococcemia and other infections caused by Neisseria meningitidis is a significant global health challenge. Substantial progress has occurred in the last twenty years in meningococcal vaccine development and global implementation. Meningococcal protein-polysaccharide conjugate vaccines to serogroups A, C, W, and Y (modeled after the Haemophilus influenzae b conjugate vaccines) provide better duration of protection and immunologic memory, and overcome weak immune responses in infants and young children and hypo-responsive to repeated vaccine doses seen with polysaccharide vaccines...
March 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29535794/neoplastic-meningitis-in-solid-tumors-from-diagnosis-to-personalized-treatments
#9
REVIEW
Alessia Pellerino, Luca Bertero, Roberta Rudà, Riccardo Soffietti
Neoplastic meningitis (NM) is a devastating complication of solid tumors with poor outcome. Some randomized clinical trials have been conducted with heterogeneous inclusion criteria, diagnostic parameters, response evaluation and primary endpoints. Recently, the Leptomeningeal Assessment in Neuro-Oncology (LANO) Group and the European Society for Medical Oncology/European Association for Neuro-Oncology have proposed some recommendations in order to provide diagnostic criteria and response evaluation scores for NM...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29521419/cochlear-implant-provider-awareness-of-vaccination-guidelines
#10
Anita Jeyakumar, Rodolpho E Bégué, Yu Jiang, Brian J McKinnon
OBJECTIVE: Guidelines for vaccination of cochlear implant (CI) recipients have been promulgated and updated by the Center for Disease Control and Prevention (CDC) to mitigate bacterial meningitis risk. The objective of this study was to survey current CI specialists on: 1) knowledge of current CDC CI recipient immunization recommendations, and 2) impediments to implementation of those guidelines. METHODS: A survey to assess knowledge of the CI recipient vaccination guidelines was administered to the American Academy of Otolaryngology-Head and Neck surgery (AAO-HNS), the American Cochlear Implant Alliance (ACIA), and the American Neurotology Society (ANS)...
March 9, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29514236/cd4-cell-count-threshold-for-cryptococcal-antigen-screening-of-hiv-infected-individuals-a-systematic-review-and-meta-analysis
#11
Nathan Ford, Zara Shubber, Joseph N Jarvis, Tom Chiller, Greg Greene, Chantal Migone, Marco Vitoria, Meg Doherty, Graeme Meintjes
Background: Current guidelines recommend screening all people living with human immunodeficiency virus (PLHIV) who have a CD4 count ≤100 cells/µL for cryptococcal antigen (CrAg) to identify those patients who could benefit from preemptive fluconazole treatment prior to the onset of meningitis. We conducted a systematic review to assess the prevalence of CrAg positivity at different CD4 cell counts. Methods: We searched 4 databases and abstracts from 3 conferences up to 1 September 2017 for studies reporting prevalence of CrAg positivity according to CD4 cell count strata...
March 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29514232/managing-advanced-hiv-disease-in-a-public-health-approach
#12
Nathan Ford, Graeme Meintjes, Alexandra Calmy, Helen Bygrave, Chantal Migone, Marco Vitoria, Martina Penazzato, Lara Vojnov, Meg Doherty
In 2017, the World Health Organization (WHO) published guidelines for the management of advanced human immunodeficiency virus (HIV) disease within a public health approach. Recent data suggest that more than a third of people starting antiretroviral therapy (ART) do so with advanced HIV disease, and an increasing number of patients re-present to care at an advanced stage of HIV disease following a period of disengagement from care. These guidelines recommend a standardized package of care for adults, adolescents, and children, based on the leading causes of morbidity and mortality: tuberculosis, severe bacterial infections, cryptococcal meningitis, toxoplasmosis, and Pneumocystis jirovecii pneumonia...
March 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29433694/antibioth%C3%A3-rapie-des-infections-n%C3%A3-onatales-bact%C3%A3-riennes-pr%C3%A3-coces-chez-les-nouveau-n%C3%A3-s-n%C3%A3-s-%C3%A3-partir-de-34-semaines-d%C3%A2-am%C3%A3-norrh%C3%A3-e
#13
O Romain
All newborns superior to 34 weeks of gestationnal age (GA) are concerned by these guidelines of the French Society of Neonatology and the French Society of Pediatrics. Only newborns at risk of Early-Onset Neonatal Bacterial Infection who are clinically symptomatic have to be treated with probabilistic antibiotherapy treatment. The antibiotic combination of choice is amoxicillin + gentamicin. The two exceptions that justify dual therapy with Cefotaxime and Gentamicin are the bacteriological documentation of Escherichia coli and/or the presence of clinical signs of severity...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29401338/a-tertiary-care-center-s-experience-with-novel-molecular-meningitis-encephalitis-diagnostics-and-implementation-with-antimicrobial-stewardship
#14
David Chang, Jason F Okulicz, Lindsey E Nielsen, Brian K White
Background: Novel molecular techniques, such as the Biofire FilmArray Meningitis/Encephalitis (ME) panel, are increasingly used to improve pathogen detection and time to detection (TtD). The Brooke Army Medical Center antibiotic stewardship program evaluated the impact of the ME panel on empiric antimicrobial usage. Methods: Negative ME panels were analyzed for days of therapy (DOT). The ME panel became available at Brooke Army Medical Center on January 1, 2016 and a retrospective chart review was performed on all hospitalized patients tested by ME panel through April 30, 2016...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29371581/hiv-associated-cryptococcal-disease-in-resource-limited-settings-a-case-for-prevention-is-better-than-cure
#15
REVIEW
Rita O Oladele, Felix Bongomin, Sara Gago, David W Denning
Cryptococcal disease remains a significant source of global morbidity and mortality for people living with HIV, especially in resource-limited settings. The recently updated estimate of cryptococcal disease revealed a global incidence of 223,100 cases annually with 73% of these cases being diagnosed in sub-Saharan Africa. Furthermore, 75% of the estimated 181,100 deaths associated with cryptococcal disease occur in sub-Saharan Africa. Point-of-care diagnostic assays have revolutionised the diagnosis of this deadly opportunistic infection...
December 2, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29371015/reactive-vaccination-as-a-control-strategy-for-pneumococcal-meningitis-outbreaks-in-the-african-meningitis-belt-analysis-of-outbreak-data-from-ghana
#16
Laura V Cooper, James M Stuart, Charles Okot, Franklin Asiedu-Bekoe, Osei Kuffour Afreh, Katya Fernandez, Olivier Ronveaux, Caroline L Trotter
Streptococcus pneumoniae is increasingly recognised as an important cause of bacterial meningitis in the African meningitis belt. The World Health Organization sets guidelines for response to outbreaks of meningococcal meningitis, but there are no current guidelines for outbreaks where S. pneumoniae is implicated. We aimed to evaluate the impact of using a similar response to target outbreaks of vaccine-preventable pneumococcal meningitis in the meningitis belt. Here, we adapt a previous model of reactive vaccination for meningococcal outbreaks to estimate the potential impact of reactive vaccination in a recent pneumococcal meningitis outbreak in the Brong-Ahafo region of central Ghana using weekly line list data on all suspected cases over a period of five months...
January 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29260780/-the-results-of-bilateral-cochlear-implantation-in-the-children-who-survived-meningitis
#17
N A Daikhes, Kh M Diab, A R Siraeva, N V Tarasova, D S Kondratchikov, A S Machalov, O A Pashchinina, A O Kuznetsov, K D Yusifov
The objective of the present study was the prospective analysis of the results of bilateral cochlear implantation (CI) in the children presenting with bilateral ossification of the cochlea after they had survived meningitis. A total of 15 patients underwent the surgical intervention. In those exhibiting bilateral ossification of the basal cochlear helix over the 5 mm segment (up to first bend of the cochlear turn) and partial ossification of the second helix (in 6 children), the affected portions were removed with the placement of two choleostomies, the lower one (from the ossified membrane of the cochlear window) and the upper one (toward the second helix)...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29189676/disseminated-cryptococcosis-with-severe-increased-intracranial-pressure-complicated-with-cranial-nerve-palsy-in-a-child
#18
Bilge Aldemir Kocabaş, Mehmet Emin Parlak, Betil Özhak Baysan, Kamil Karaali, Ayşen Bingöl, Şenay Haspolat
Cryptococcosis is less common in children than in adults but remains an important cause of pneumonia and meningoencephalitis in both immunocompromised and immunocompetent patients. Intracranial hypertension commonly complicates cryptococcal meningitis and may cause significant visual and neurologic morbidity and mortality. Early and aggressive management of intracranial hypertension in accordance with established guidelines reduces the risk of long-term complications and death. In this case report, we present a 12-year-old girl with cryptococcal meningitis, pneumonitis and dermatitis complicated with cranial nerve palsy and loss of vision...
April 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29088943/the-role-of-icp-monitoring-in-meningitis
#19
Areej Tariq, Pedro Aguilar-Salinas, Ricardo A Hanel, Neeraj Naval, Mohamad Chmayssani
Intracranial pressure (ICP) monitoring has been widely accepted in the management of traumatic brain injury. However, its use in other pathologies that affect ICP has not been advocated as strongly, especially in CNS infections. Despite the most aggressive and novel antimicrobial therapies for meningitis, the mortality rate associated with this disease is far from satisfactory. Although intracranial hypertension and subsequent death have long been known to complicate meningitis, no specific guidelines targeting ICP monitoring are available...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29026671/bilateral-caudate-nucleus-infarcts-a-case-report-of-a-rare-complication-following-endoscopic-resection-of-a-tuberculum-sellae-meningioma
#20
Joel Bierer, Amparo Wolf, Donald H Lee, Brian W Rotenberg, Neil Duggal
BACKGROUND: We present a rare complication of bilateral caudate infarcts and necrosed nasoseptal flaps after endoscopic transsphenoidal resection of tuberculum sellae meningioma. This case highlights the importance of early and accurate diagnosis and treatment of a postoperative cerebrospinal fluid (CSF) leak and associated bacterial meningitis, and reviews any existing guidelines regarding its management. CASE DESCRIPTION: A 54-year-old otherwise healthy man presented with progressive bitemporal hemianopsia...
2017: Surgical Neurology International
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