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headache neuroscience

Moneer K Faraj, Wissam J Sagban
OBJECTIVE: To review the patients operated by endoscopic transphenoidal approach for skull base lesions. All the clinical data including age, gender, type of pathology, surgical outcome and surgical complications were studied. METHODS: A clinical prospective study was conducted on 94 cases with skull base lesion that were treated in Neuroscience Hospital in Baghdad, Iraq between October 2011 and December 2016. We followed each patient for an average of 2 years after surgery to determine most common lesion involving the skull base, age and gender distribution, surgical outcome, complications and hospital accommodation...
January 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Mario Giordano, Massimo Gallieni, Amir Samii, Concezio Di Rocco, Madjid Samii
OBJECTIVE Few cases of cerebellopontine angle (CPA) arachnoid cysts in pediatric patients have been described in the literature, and in only 2 of these cases were the patients described as suffering from hearing deficit. In this article, the authors report on 3 pediatric patients with CPA arachnoid cysts (2 with hearing loss and 1 with recurrent headaches) who underwent neurosurgical treatment at the authors' institution. METHODS Four pediatric patients were diagnosed with CPA arachnoid cysts at the International Neuroscience Institute during the period from October 2004 through August 2012, and 3 of these patients underwent surgical treatment...
February 2018: Journal of Neurosurgery. Pediatrics
Brian Mac Grory, Linh Vu, Shawna Cutting, Evadne Marcolini, Christopher Gottschalk, David Greer
INTRODUCTION: Subarachnoid hemorrhage (SAH) is a life-threatening emergency that is frequently missed due to its varied and often subtle presentation. The most common presentation of SAH is with a severe headache. The classical adjective used in SAH is "thunderclap"; however, this has not been well defined in the literature, rendering it a challenge to triage patients in clinical practice presenting with severe headache. METHODS: We undertook a prospective, observational study at a tertiary academic medical center examining the clinical characteristics of the presenting headache in SAH...
November 4, 2017: Headache
Zeinab Esmaeilpour, Pedro Schestatsky, Marom Bikson, André R Brunoni, Ada Pellegrinelli, Fernanda X Piovesan, Mariana M S A Santos, Renata B Menezes, Felipe Fregni
Background: Transcranial direct current stimulation (tDCS) is investigated to modulate neuronal function including cognitive neuroscience and neuropsychiatric therapies. While cases of human stimulation with rudimentary batteries date back more than 200 years, clinical trials with current controlled stimulation were published intermittently since the 1960s. The modern era of tDCS only started after 1998. Objectives: To review methods and outcomes of tDCS studies from old literature (between 1960 and 1998) with intention of providing new insight for ongoing tDCS trials and development of tDCS protocols especially for the purpose of treatment...
2017: Frontiers in Human Neuroscience
J Lansley, C Selai, A S Krishnan, K Lobotesis, H R Jäger
OBJECTIVES: To establish if emergency medicine and neuroscience specialist consultants have different risk tolerances for investigation of suspected spontaneous subarachnoid haemorrhage (SAH), and to establish if their risk-benefit appraisals concur with current guidelines. SETTING: 4 major neuroscience centres in London. PARTICIPANTS: 58 consultants in emergency medicine and neuroscience specialities (neurology, neurosurgery and neuroradiology) participated in an anonymous survey...
September 15, 2016: BMJ Open
Domenico Solari, Luigi Maria Cavallo, Teresa Somma, Carmela Chiaramonte, Felice Esposito, Marialaura Del Basso De Caro, Paolo Cappabianca
OBJECTIVE: Rathke's cleft cysts (RCCs) are quite uncommon sellar lesions that can extend or even arise in the suprasellar area. The purpose of this study is to evaluate the effectiveness of both standard and extended endoscopic endonasal approaches in the management of different located RCCs. METHODS: We retrospectively analyzed a series of 29 patients (9 males, 20 females) complaining of a RCC, who underwent a standard or an extended endoscopic transsphenoidal approach at the Division of Neurosurgery, Department of Neurosciences and Reproductive and Odontostomatological Sciences, of the Università degli Studi di Napoli "Federico II"...
2015: PloS One
Peter J Goadsby
Migraine is a common, complex brain disorder whose biology is becoming better understood. Despite being the most disabling of the neurological disorders on a worldwide basis, headache disorders broadly, and migraine in particular, have poor research funding and a limited academic base. Given a modicum of investment, new targets, such as calcitonin gene-related peptide-based mechanisms, and entirely novel neuromodulation approaches illustrate that much can be done to improve patient care. Genetics and neuroimaging combined with excellent clinical phenotyping and translational neuroscience approaches are set to transform life for a cohort of patients with these common brain disorders...
September 2013: Annals of Neurology
Laxmi P Dhakal, David O Hodge, Jay Nagel, Jay Nagal, Michael Mayes, Alexa Richie, Lauren K Ng, William D Freeman
BACKGROUND: Headache after aneurysmal subarachnoid hemorrhage (SAH) is very common and is often described as the "worst headache imaginable." SAH-associated headache can persist for days to weeks and is traditionally treated with narcotics. However, narcotics can have significant adverse effects. We hypothesize that gabapentin (GBP), a non-narcotic neuropathic pain medication, would be safe and tolerable and would reduce narcotic requirements after SAH. METHODS: We retrospectively reviewed the clinical, radiographic, and laboratory data of SAH patients at the neuroscience intensive care unit at Mayo Clinic in Jacksonville, Florida, from January 2011 through February 2013...
June 2015: Neurocritical Care
Ali A Alhaboob, Gamal M Hasan, Muhammad A Malik, Muhammad Z Rehman
BACKGROUND: Childhood primary angiitis of central nervous system (cPACNS) is rare idiopathic vasculitis most frequently in adults. Children with this disorder can present with a range of neurological symptoms and signs including decreased consciousness, seizures, hemiparesis, cranial nerve deficits, and cognitive deficits. Delayed diagnosis and treatment may compromise the outcome. Therapeutic modalities including Anti-Platelet agents, Corticosteroids, Azathioprine, Cyclophosphamide and other Immunomodulatory agents have been used with variable success...
January 2014: Annals of Neurosciences
Jo Nijs, Anneleen Malfliet, Kelly Ickmans, Isabel Baert, Mira Meeus
INTRODUCTION: Central sensitization (CS) is present in a variety of chronic pain disorders, including whiplash, temporomandibular disorders, low back pain, osteoarthritis, fibromyalgia, headache, lateral epicondylalgia among others. In spite of our increased understanding of the mechanisms involved in CS pain, its treatment remains a challenging issue. AREAS COVERED: An overview of the treatment options we have for desensitising the CNS in patients with CS pain is provided...
August 2014: Expert Opinion on Pharmacotherapy
Anne Destrebecq, Stefano Terzoni, Elena Sala
Headache is the most common complication after lumbar puncture. This narrative review explores the literature to determine strategies for preventing headache and provide evidence-based nursing care to adults with post-lumbar puncture headache. Multiple findings regarding prevention and relieving of post-lumbar puncture headache were identified and summarized under the headings "Needle Design and LP Technical Procedure," "Bed Rest and Early Mobilization," "Posture and Head Position," "Cerebral Vasoconstriction," "Hydration and Seal of the Puncture Site," and "Patient Characteristics...
June 2014: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Esther H Bay, Kattlynn S Chartier
Emerging data suggest that traumatic brain injury (TBI) is a disease process with considerable long-range morbidities requiring lifelong monitoring and treatment. Multiple chronic morbidities develop across the life span after TBI, including mental health disorders, headaches, seizures, and neuroendocrine imbalances as well as chronic diseases. Still, there has been limited focus on effective guides and strategies for helping persons with TBI meet their chronic health needs as they live with the consequences of TBI...
June 2014: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Paul Rolan
Paul Rolan speaks to Roshaine Gunawardana, Commissioning Editor: Paul Rolan graduated in Medicine (MBBS) from the University of Adelaide, Australia, in 1979 and trained in internal medicine and clinical pharmacology. In 1987, he went to the UK to work at the Wellcome Research Laboratories where he was responsible for the exploratory development of a range of compounds, some of which became marketed (atovaquone, zolmitriptan). He was awarded an MD degree from the University of Adelaide in 1995 for novel conceptual work on the use of biomarkers in exploratory development for work performed while at Wellcome...
May 2012: Pain Management
Cesar Fernández-de-Las-Peñas
Cesar Fernández-de-las-Peñas completed his Bachelor's degree in Physical Therapy in 2000, in Spain. He obtained his first PhD degree in Biomedical Sciences in 2007, under the supervision of Dr Lars Arendt-Nielsen at the Sensory-Motor Interaction Center at the University of Aalborg (Denmark). In 2008, he obtained his second PhD degree in Preventive Medicine, under the supervision of Drs Pareja and Cuadrado in Spain. He is the Head of the Division of the Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine at Universidad Rey Juan Carlos, Spain...
March 2012: Pain Management
Anne Thushara Matthias, Poorna Nagasingha, Priyanga Ranasinghe, Saman B Gunatilake
BACKGROUND: Neurophobia is the fear of neurosciences held by medical students and doctors. The present study aims to identify whether Neurology is considered a difficult subject by medical students and non-specialist doctors from Sri Lanka and evaluate reasons for such perceived difficulties. METHODS: The study was conducted from May-June 2008. One hundred non-specialist doctors from the Colombo South Teaching Hospital and 150 medical students from the University of Sri Jayewardenepura were invited for the study...
2013: BMC Medical Education
Naomi A Fineberg, Peter M Haddad, Lewis Carpenter, Brenda Gannon, Rachel Sharpe, Allan H Young, Eileen Joyce, James Rowe, David Wellsted, David J Nutt, Barbara J Sahakian
AIM: The aim of this paper is to increase awareness of the prevalence and cost of psychiatric and neurological disorders (brain disorders) in the UK. METHOD: UK data for 18 brain disorders were extracted from a systematic review of European epidemiological data and prevalence rates and the costs of each disorder were summarized (2010 values). RESULTS: There were approximately 45 million cases of brain disorders in the UK, with a cost of €134 billion per annum...
September 2013: Journal of Psychopharmacology
G Tedeschi, A Russo, F Conte, F Salemi, A Tessitore
Migraine is a neurologic disorder characterized by disabling attacks of throbbing headache with specific features and associated symptoms. Despite the recent discoveries in basic neurosciences, migraine pathophysiology is not completely understood. Nevertheless, in the last decades, advances in functional magnetic resonance imaging (fMRI) have significantly provided new insights into migraine mechanisms. Blood oxygen level dependent (BOLD) fMRI technique is the most commonly used method to explore brain function and connectivity due to high temporal and spatial resolution...
May 2013: Neurological Sciences
Arne May
PREMISE: One of the most exciting developments in modern neuroscience was the development of imaging techniques providing a non-invasive technique for detection of structure-function relationships characteristic of pain and headache. There is no question that neuroimaging has provided us with a better understanding of how the aura in migraine develops, and it has served as a bridge between neurophysiological studies and clinical findings, although doubtless several questions remain. PEARLS: Neuroimaging drew attention toward central mechanisms in idiopathic headache syndromes...
June 2013: Cephalalgia: An International Journal of Headache
Monica Updyke, Barbara Duryea
Epilepsy is the second most common neurological disorder after migraines and headaches, with an economic burden of 15.5 billion dollars annually. Most patients with epilepsy can be controlled with antiepileptic drugs. Those who remain uncontrolled are considered refractory and are often admitted to an epilepsy monitoring unit for definitive diagnosis. Nonepileptic seizures are a common differential diagnosis in persons with refractory seizures. It is helpful for providers to witness the patients' seizures to make a definitive diagnosis for seizure classification...
June 2013: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Hellmuth Obrig
Near-infrared spectroscopy (NIRS) has become a relevant research tool in neuroscience. In special populations such as infants and for special tasks such as walking, NIRS has asserted itself as a low resolution functional imaging technique which profits from its ease of application, portability and the option to co-register other neurophysiological and behavioral data in a 'near natural' environment. For clinical use in neurology this translates into the option to provide a bed-side oximeter for the brain, broadly available at comparatively low costs...
January 15, 2014: NeuroImage
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