keyword
https://read.qxmd.com/read/37920678/a-synergistic-blend-of-garcinia-mangostana-fruit-rind-and-cinnamomum-tamala-leaf-extracts-enhances-myogenic-differentiation-and-mitochondrial-biogenesis-in-vitro-and-muscle-growth-and-strength-in-mice
#1
JOURNAL ARTICLE
Swaraj Sinha, Krishnaraju Venkata Alluri, Venkateswarlu Somepalli, Trimurtulu Golakoti, Krishanu Sengupta
BACKGROUND: A proprietary combination of Garcinia mangostana fruit rind and Cinnamomum tamala leaf extracts (LI80020F4, CinDura® ) improved the physical performance and muscle strength of resistance-trained adult males. OBJECTIVE: This study assessed the underlying mechanisms of the ergogenic potential of LI80020F4 in in vitro and in vivo models. METHODS: The individual extracts and their combination (LI80020F4) were assessed for nitrite production in EAhy926 human endothelial cells...
2023: Food & Nutrition Research
https://read.qxmd.com/read/37649908/long-term-combination-therapy-with-metformin-and-oxymetholone-in-a-fanconi-anemia-mouse-model
#2
Craig Dorrell, Alexander M Peters, Qingshuo Zhang, Niveditha Balaji, Kevin Baradar, Makiko Mochizuki-Kashio, Angela Major, Milton Finegold, Chih-Wei Liu, Kun Lu, Markus Grompe
UNLABELLED: Fanconi Anemia (FA) is a disease caused by defective DNA repair which manifests as bone marrow failure, cancer predisposition, and developmental defects. Mice containing inactivating mutations in one or more genes in the FA pathway partially mimic the human disease. We previously reported that monotherapy with either metformin (MET) or oxymetholone (OXM) improved peripheral blood (PB) counts and the number and functionality of bone marrow (BM) hematopoietic stem progenitor cells (HSPCs) number in Fancd2 -/- mice...
August 16, 2023: bioRxiv
https://read.qxmd.com/read/37393722/real-world-costs-and-cost-effectiveness-analysis-of-rabbit-antithymocyte-globulin-versus-oxymetholone-in-acquired-aplastic-anemia-in-thailand
#3
JOURNAL ARTICLE
Thitichaya Penthinapong, Pirun Saelue, Warunsuda Sripakdee, Thitima Doungngern, Pimwara Tanvejsilp
OBJECTIVES: This study aimed to compare rabbit-antithymocyte globulin and cyclosporine (rATG/CsA) with oxymetholone in terms of direct medical expenditures and economic evaluation in severe acquired aplastic anemia (SAA) and very severe acquired aplastic anemia (vSAA) patients. METHODS: Patients with SAA/vSAA who initiated treatment with rATG/CsA or oxymetholone between 2004 and 2018 were included. Trial-based cost-effectiveness evaluation in healthcare provider perspective was performed...
June 30, 2023: Value in Health Regional Issues
https://read.qxmd.com/read/37366872/effects-of-platelet-rich-plasma-on-the-oxymetholone-induced-testicular-toxicity
#4
JOURNAL ARTICLE
Amal I Saba, Reda H Elbakary, Omayma K Afifi, Heba E M Sharaf Eldin
Oxymetholone is one of the anabolic steroids that has widely been used among teenagers and athletes to increase their muscle bulk. It has undesirable effects on male health and fertility. In this study, the therapeutic effects of platelet-rich plasma (PRP) on oxymetholone-induced testicular toxicity were investigated in adult albino rats. During the experiments, 49 adult male albino rats were divided into 4 main groups: Group 0 (donor group) included 10 rats for the donation of PRP, Group I (control group) included 15 rats, Group II included 8 rats that received 10 mg/kg of oxymetholone orally, once daily, for 30 days, and Group III included 16 rats and was subdivided into 2 subgroups (IIIa and IIIb) that received oxymetholone the same as group II and then received PRP once and twice, respectively...
June 9, 2023: Diseases (Basel)
https://read.qxmd.com/read/37037411/extended-steroid-profiling-in-h295r-cells-provides-deeper-insight-into-chemical-induced-disturbances-of-steroidogenesis-exemplified-by-prochloraz-and-anabolic-steroids
#5
JOURNAL ARTICLE
Marie-Christin Jäger, Melanie Patt, Víctor González-Ruiz, Julien Boccard, Tim Wey, Denise V Winter, Serge Rudaz, Alex Odermatt
Human adrenocortical H295R cells have been validated by the OECD Test Guideline 456 to detect chemicals disrupting testosterone and 17β-estradiol (estradiol) biosynthesis. This study evaluated a novel approach to detect disturbances of steroidogenesis in H295R cells, exemplified by prochloraz and five anabolic steroids. Steroid profiles were assessed by an untargeted LC-MS-based method, providing a relative quantification of 57 steroids annotated according to their accurate masses and retention times...
June 15, 2023: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/36942061/simultaneous-analysis-and-efficient-separation-of-anabolic-androgenic-steroids-in-dietary-supplement-by-a-validated-hptlc-method
#6
JOURNAL ARTICLE
Zeinab Saadabadi, Bahram Daraei, Farzad Kobarfard, Maryam Amirahmadi, Kolsum Kheirollahi
BACKGROUND: Using sports supplements is common among athletes. The presence of anabolic steroids in sports supplements as a hormonal contaminant can increase production efficiency. Since anabolic steroids cause health problems and result in positive doping tests in athletes, it is important to investigate their presence in the supplement preparations consumed by athletes. OBJECTIVES: This paper aims to simultaneously determine ten anabolic steroids by high-performance thin-layer chromatography (HPTLC) method in sports supplements...
December 2022: Iranian Journal of Pharmaceutical Research: IJPR
https://read.qxmd.com/read/36514313/efficacy-of-oxymetholone-in-severe-and-nonsevere-acquired-aplastic-anemia-a-propensity-score-matching-analysis
#7
JOURNAL ARTICLE
Worachaya Pengthina, Pirun Saelue
BACKGROUND: Bone marrow transplantation, antithymocyte globulin/cyclosporine and eltrombopag are recommended as first-line therapy of severe aplastic anemia (SAA). However, androgens could be considered as front-line treatment among any patients ineligible for better methods although unsatisfactory efficacy is presented. OBJECTIVE: This retrospective study aimed to evaluate response and survival rate of practical-based treatment with oxymetholone. PATIENTS AND METHODS: This constituted an analysis of patients receiving a diagnosis of acquired aplastic anemia (AA) at the age of 15 or over and receiving oxymetholone between January 2004 and December 2018...
2022: Journal of Blood Medicine
https://read.qxmd.com/read/35929966/the-biology-and-management-of-dyskeratosis-congenita-and-related-disorders-of-telomeres
#8
REVIEW
Hemanth Tummala, Amanda Walne, Inderjeet Dokal
BACKGROUND: Dyskeratosis congenita (DC) is a multisystem syndrome characterized by mucocutaneous abnormalities, bone marrow failure, and predisposition to cancer. Studies over the last 25 years have led to the identification of 18 disease genes. These have a principal role in telomere maintenance, and patients usually have very short/abnormal telomeres. The advances have also led to the unification of DC with a number of other diseases, now collectively referred to as the telomeropathies or telomere biology disorders...
August 2022: Expert Review of Hematology
https://read.qxmd.com/read/35633194/renoprotective-and-hepatoprotective-activity-of-lepidium-draba-l-extracts-on-oxymetholone-induced-oxidative-stress-in-rat
#9
JOURNAL ARTICLE
Jinge Feng, Hongbo Gao, Lin Yang, Yu Xie, Ayman E El-Kenawy, Attalla F El-Kott
Misuse and abuse of anabolic androgenic steroids (AAS) such as oxymetholone (OM) cause side effects such as male infertility, cardiovascular disorders, musculoskeletal, and hepato-renal dysfunctions in athletes. The aim of this study was to evaluate the protective effects of Lepidium draba L. (L. draba) extract on OM-induced hepato-renal toxicity. Thirty adult male Wistar rats into six groups (n = 5) were randomly divided as follows: control (normal saline), OM (5 mg/kg/day), L. draba-treated (100, 200, and 400 mg/kg/d) plus 5 mg/kg/day OM, and L...
May 28, 2022: Journal of Food Biochemistry
https://read.qxmd.com/read/34520070/protective-effects-of-lepidium-draba-l-leaves-extract-on-testis-histopathology-oxidative-stress-indicators-serum-reproductive-hormones-and-inflammatory-signalling-in-oxymetholone-treated-rat
#10
JOURNAL ARTICLE
Yanbo Wang, Liang Bai, Huiting Li, Wenjun Yang, Min Li
This study was aimed to investigate the protective effects of Lepidium draba L. (L. draba) extract on oxymetholone (OM)-induced testicular injury in rat. Six groups of n = 5 adult male rats were used as; 1: control, 2: OM (5 mg/kg OM orally), 3, 4 and 5: L. draba extract (100, 200 and 400 mg kg-1  day-1 ) +OM (5 mg kg-1  day-1 OM) and 6:400 mg/kg/d L. draba extract for 30 days. Serum testosterone (T), follicle-stimulating hormone (FSH) and luteinising hormone (LH), inflammatory cytokines (IL-6, IL-10, TNF-α, IL-1β), oxidative stress (OS) indicators [superoxide dismutase, catalase, glutathione peroxidase and nitric oxide (NO)], apoptotic related genes (Bcl-2, p53, caspase-3 (c3) and Bax) were investigated...
December 2021: Andrologia
https://read.qxmd.com/read/33915816/tailor-made-immunochromatographic-test-for-the-detection-of-multiple-17%C3%AE-methylated-anabolics-in-dietary-supplements
#11
JOURNAL ARTICLE
Barbora Holubová, Pavla Kubešová, Lukáš Huml, Miroslav Vlach, Oldřich Lapčík, Michal Jurášek, Ladislav Fukal
In recent years, the undeclared presence of various anabolic androgenic steroids (AAS) in commercial supplements has been confirmed. This fact can be a potential threat to all athletes using these supplements, and therefore, there is of increased interest in the implementation of rapid methods for the detection of AAS. The presented study describes the development of an immunostrip test for the detection of multiple 17α-methylated AAS based on direct and indirect competitive principle using gold nanoparticles as a label...
April 1, 2021: Foods (Basel, Switzerland)
https://read.qxmd.com/read/33560087/eltrombopag-add-on-treatment-in-a-child-with-fanconi-aplastic-anemia-awaiting-hematopoietic-stem-cell-transplantation
#12
JOURNAL ARTICLE
Sultan Aydin Koker, Arzu Çalişkan Polat
Fanconi aplastic anemia (FAA) is a rare inherited bone marrow failure disorder characterized by congenital defects and pancytopenia. Hematopoietic stem cell transplantation (HSCT) is a curative treatment for patients with FAA due to the risk of cancer and pancytopenia. Blood transfusions are the best supportive therapy. Oxymetholone (5 mg/kg daily) is most commonly used; however, it is not curative. Extensive transfusions should be avoided because of alloimmunization and graft-versus-host disease because they have poor outcomes in patients with HSCT...
February 3, 2021: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/33003434/comparable-effects-of-the-androgen-derivatives-danazol-oxymetholone-and-nandrolone-on-telomerase-activity-in-human-primary-hematopoietic-cells-from-patients-with-dyskeratosis-congenita
#13
JOURNAL ARTICLE
Margherita Vieri, Martin Kirschner, Mareike Tometten, Anne Abels, Benjamin Rolles, Susanne Isfort, Jens Panse, Tim H Brümmendorf, Fabian Beier
Dyskeratosis congenita (DKC) is a rare inherited disease of impaired telomere maintenance that progressively leads to multi-organ failure, including the bone marrow. By enhancing telomerase activity, androgen derivatives (ADs) are a potential therapeutic option able to re-elongate previously shortened telomeres. Danazol, oxymetholone, and nandrolone are ADs most frequently used to treat DKC. However, no direct in vitro analyses comparing the efficacy of these ADs have been conducted so far. We therefore treated mononuclear cells derived from peripheral blood and bone marrow of four patients with mutations in telomerase reverse transcriptase ( TERT , n = 1),in the telomerase RNA component (TERC, n = 2) and in dyskerin pseudouridine synthase 1 ( DKC1 , n = 1) and found no substantial differences in the activity of these three agents in patients with TERC/TERT mutations...
September 29, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32537903/analytical-approaches-applied-to-the-analysis-of-apprehended-formulations-of-anabolic-androgenic-steroids
#14
COMPARATIVE STUDY
Lucas M Berneira, Caroline C da Silva, Luan F Passos, Tais Poletti, Marco A Z Dos Santos, Claudio M P de Pereira
Anabolic androgenic steroids (AASs) comprise a class of synthetic androgens resulting from chemical modifications of testosterone, known for their illicit consumption, which can result inextensive side effects. Extraction procedures applied to the analysis of their formulations are still limited to a few methodologies, despite the increasing numbers of confiscations of AASs. In this sense, the aims of this work were to evaluate the extraction of active ingredients from formulations of anabolic agents using solid-liquid or liquid-iquid, ultrasonic bath, ultrasonicprobe, and microwave-assisted extraction...
September 2020: Drug Testing and Analysis
https://read.qxmd.com/read/32128787/androgen-therapy-in-inherited-bone-marrow-failure-syndromes-analysis-from-the-canadian-inherited-marrow-failure-registry
#15
JOURNAL ARTICLE
Albert Català, Salah S Ali, Geoffrey D E Cuvelier, MacGregor Steele, Robert J Klaassen, Conrad V Fernandez, Yves D Pastore, Sharon Abish, Meera Rayar, Lawrence Jardine, Vicky R Breakey, Josee Brossard, Roona Sinha, Mariana Silva, Lisa Goodyear, Jeffrey H Lipton, Bruno Michon, Catherine Corriveau-Bourque, Lillian Sung, Supanun Lauhasurayotin, Bozana Zlateska, Michaela Cada, Yigal Dror
Progressive cytopenia is a serious complication among paediatric patients with inherited bone marrow failure syndromes (IBMFS). Androgens have been used to improve blood counts in different bone marrow failure conditions. Little is known about efficacy and toxicity with new androgens (i.e., danazol) in different types of IBMFS. We identified 29 patients from the Canadian Inherited Marrow Failure Registry, who received oxymetholone or danazol. Sixteen (55%) had haematological response including patients with unclassified IBMFS (45%)...
June 2020: British Journal of Haematology
https://read.qxmd.com/read/32012329/the-effects-of-hydroalcoholic-extract-of-vaccinium-arctostaphylos-l-on-sperm-parameters-oxidative-injury-and-apoptotic-changes-in-oxymetholone-induced-testicular-toxicity-in-mouse
#16
JOURNAL ARTICLE
Mohsen Akbari Bazm, Nader Goodarzi, Seyed Reza Shahrokhi, Mozafar Khazaei
Anabolic androgenic steroids (AAS) such as oxymetholone (OM) used for athletic enhancement, but increased free radicals damage and changes in hormonal levels, lead to serious and irreversible organ damage. Vaccinium arctostaphylos(V. arctostaphylos( has been demonstrated to have antioxidant and antiinflammatory effects. The aim of present study was to investigate V. arctostaphylos effect on OM-induced oxidative injury in mouse testis and sperm parameters. In this experimental study, 30 BALB/c mice were divided into five groups, including healthy, positive control(5 mg/kg OM) and three treatment groups (100, 200 and 400 mg/kg of V...
April 2020: Andrologia
https://read.qxmd.com/read/31884045/profiling-of-anabolic-androgenic-steroids-and-selective-androgen-receptor-modulators-for-interference-with-adrenal-steroidogenesis
#17
JOURNAL ARTICLE
Melanie Patt, Katharina R Beck, Tobias Di Marco, Marie-Christin Jäger, Victor González-Ruiz, Julien Boccard, Serge Rudaz, Rolf W Hartmann, Mohamed Salah, Chris J van Koppen, Matthias Grill, Alex Odermatt
Anabolic-androgenic steroids (AAS) are testosterone derivatives developed for steroid-replacement and treatment of debilitating conditions. They are widely used by athletes in elite sports and bodybuilding due to their muscle-building and performance-enhancing properties. Excessive AAS use is associated with cardiovascular diseases, mood changes, endocrine and metabolic disorders; however, the underlying mechanisms remain unknown. Selective androgen receptor modulators (SARMs) aim to reduce adverse androgenic effects, while maximizing anabolic effects...
February 2020: Biochemical Pharmacology
https://read.qxmd.com/read/31812623/stanazolol-derived-elisa-as-a-sensitive-forensic-tool-for-the-detection-of-multiple-17%C3%AE-methylated-anabolics
#18
JOURNAL ARTICLE
Lukáš Huml, Dominika Havlová, Ondřej Longin, Eliška Staňková, Barbora Holubová, Martin Kuchař, Elena Prokudina, Zdeňka Rottnerová, Tomáš Zimmermann, Pavel Drašar, Oldřich Lapčík, Michal Jurášek
Two valuable forensic tools based on enzyme-linked immunoassays (ELISAs) for the analysis of 17α-methylated steroids were developed using haptens of stanazolol and its conjugates with biotin. Haptens containing terminal carboxylic group were conjugated to bovine serum albumin (BSA), rabbit serum albumin (RSA) or ovalbumin (OVA). Eight batches of antisera (RAbs) obtained by immunization of rabbits were tested in an indirect competitive ELISA system using immobilization of RSA conjugate (RSA/hapten) and competitor immobilization of the biotinylated conjugate (AB-ELISA) to avidin (avidin/hapten)...
March 2020: Steroids
https://read.qxmd.com/read/31229510/synthesis-of-a-human-long-term-oxymetholone-metabolite
#19
JOURNAL ARTICLE
Nicolas Kratena, Nina Biedermann, Biljana Stojanovic, Lorenz Göschl, Matthias Weil, Valentin S Enev, Günter Gmeiner, Peter Gärtner
A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17β-hydroxymethyl-2,17α-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The identity and molecular configuration of the in vivo metabolite: 17β-hydroxymethyl-2α,17α-methyl-18-norandrost-13-en-3-one was confirmed by single crystal X-ray diffraction.
October 2019: Steroids
https://read.qxmd.com/read/31025410/nasturtium-officinale-l-hydroalcoholic-extract-improved-oxymetholone-induced-oxidative-injury-in-mouse-testis-and-sperm-parameters
#20
JOURNAL ARTICLE
Mohsen Akbari Bazm, Mozafar Khazaei, Fatemeh Khazaei, Leila Naseri
Testicular tissue and sex hormones are sensitive to the anabolic steroids (oxymetholone/OM) due to increased free radical damage and hormonal changes. The Nasturtium officinale L. have various antioxidant compounds. The aim of the present study was to investigate N. officinale effect on OM-induced oxidative injury in mouse testis and sperm parameters. Thirty BALB/c mice were divided into five groups, including control, OM (5 ml/kg) and three N. officinale doses (25, 50 and 100 mg/kg) + OM. At the end of the study (40 days), serum luteinising hormone (LH), follicle-stimulating hormone (FSH), testosterone, nitric oxide (NO) levels, ferric reducing ability of power (FRAP) and testis stereological factors were measured...
August 2019: Andrologia
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