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https://www.readbyqxmd.com/read/27846633/variations-in-thalamic-anatomy-affect-targeting-in-deep-brain-stimulation-for-epilepsy
#1
Chengyuan Wu, Pierre-François D'Haese, Srivatsan Pallavaram, Benoit M Dawant, Peter Konrad, Ashwini D Sharan
BACKGROUND: Thalamic size and shape vary significantly across patients - with changes specific to the anterior thalamus occurring with age and in the setting of chronic epilepsy. Such ambiguity raises concerns regarding electrode position and potential implications for seizure outcomes. METHODS: MRIs from 6 patients from a single center underwent quantitative analysis. In addition to direct measurements from postimplantation MRIs, the CRAnialVault Explorer suite was used to normalize electrode position to a common reference system...
November 16, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27723660/relationship-between-postoperative-eeg-driving-response-and-lead-location-in-deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-for-refractory-epilepsy
#2
Byung-Chul Son, Young Min Shon, Seong-Hoon Kim, Jin-Gyu Choi, Jiyeon Kim
OBJECTIVES: Interpreting the postoperative electroencephalographic (EEG) driving response (DR) as an indicator of electrode placement within the thalamic nucleus in deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) for refractory epilepsy is controversial. MATERIALS AND METHODS: We retrospectively investigated the relationship between postoperative EEG DR and the location of 11 electrodes in 6 patients who underwent ANT DBS for refractory epilepsy...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27715438/prediction-and-detection-of-seizures-from-simultaneous-thalamic-and-scalp-electroencephalography-recordings
#3
Rosa Q So, Vibhor Krishna, Nicolas Kon Kam King, Huijuan Yang, Zhuo Zhang, Francesco Sammartino, Andres M Lozano, Richard A Wennberg, Cuntai Guan
OBJECTIVE The authors explored the feasibility of seizure detection and prediction using signals recorded from the anterior thalamic nucleus, a major target for deep brain stimulation (DBS) in the treatment of epilepsy. METHODS Using data from 5 patients (13 seizures in total), the authors performed a feasibility study and analyzed the performance of a seizure prediction and detection algorithm applied to simultaneously acquired scalp and thalamic electroencephalography (EEG). The thalamic signal was obtained from DBS electrodes...
October 7, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27645504/an-unexpectedly-high-rate-of-revisions-and-removals-in-deep-brain-stimulation-surgery-analysis-of-multiple-databases
#4
John D Rolston, Dario J Englot, Philip A Starr, Paul S Larson
INTRODUCTION: Deep brain stimulation (DBS) is an established therapy for movement disorders, and is under active investigation for other neurologic and psychiatric indications. While many studies describe outcomes and complications related to stimulation therapies, the majority of these are from large academic centers, and results may differ from those in general neurosurgical practice. METHODS: Using data from both the Centers for Medicare and Medicaid Services (CMS) and the National Surgical Quality Improvement Program (NSQIP), we identified all DBS procedures related to primary placement, revision, or removal of intracranial electrodes...
September 12, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27642815/effectiveness-and-adverse-effects-of-deep-brain-stimulation-umbrella-review-of-meta-analyses
#5
Panagiotis N Papageorgiou, James Deschner, Spyridon N Papageorgiou
Background This umbrella review summarizes the evidence across meta-analyses regarding the effectiveness and adverse effects of deep brain stimulation (DBS). Methods Databases were searched up to March 2015 for meta-analyses of comparative trials in humans assessing the effectiveness or adverse effects of DBS. Data selection, data extraction, and risk of bias assessment were performed by two independent reviewers. Results Seven eligible systematic reviews were included assessing the use of DBS for epilepsy (n = 1), obsessive-compulsive disorder (n = 1), and Parkinson disease (n = 5)...
September 19, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27636181/modification-of-electrophysiological-activity-pattern-after-anterior-thalamic-deep-brain-stimulation-for-intractable-epilepsy-report-of-3-cases
#6
Hae Yu Kim, Yun Jung Hur, Heung-Dong Kim, Kang Min Park, Sung Eun Kim, Tae Gyu Hwang
OBJECTIVE Thalamic stimulation can provoke electroencephalography (EEG) synchronization or desynchronization, which can help to reduce the occurrence of seizures in intractable epilepsy, though the underlying mechanism is not fully understood. Therefore, the authors investigated changes in EEG electrical activity to better understand the seizure-reducing effects of deep brain stimulation (DBS) in patients with intractable epilepsy. METHODS Electrical activation patterns in the epileptogenic brains of 3 patients were analyzed using classical low-resolution electromagnetic tomography analysis recursively applied (CLARA)...
September 16, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27620666/a-new-bio-inspired-stimulator-to-suppress-hyper-synchronized-neural-firing-in-a-cortical-network
#7
Masoud Amiri, Mahmood Amiri, Soheila Nazari, Karim Faez
Hyper-synchronous neural oscillations are the character of several neurological diseases such as epilepsy. On the other hand, glial cells and particularly astrocytes can influence neural synchronization. Therefore, based on the recent researches, a new bio-inspired stimulator is proposed which basically is a dynamical model of the astrocyte biophysical model. The performance of the new stimulator is investigated on a large-scale, cortical network. Both excitatory and inhibitory synapses are also considered in the simulated spiking neural network...
September 13, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27605389/a-closed-loop-brain-machine-interface-for-epilepsy-control-using-dorsal-column-electrical-stimulation
#8
Miguel Pais-Vieira, Amol P Yadav, Derek Moreira, David Guggenmos, Amílcar Santos, Mikhail Lebedev, Miguel A L Nicolelis
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures...
September 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27567879/brain-stimulation-in-alzheimer-s-disease
#9
Itzhak Fried
Deep brain stimulation has been successfully used in treatment of motor symptoms of Parkinson's disease and other movement disorders. In a recent multi-center prospectively randomized study, deep brain stimulation of the fornix was administered in order to ameliorate the cognitive symptoms and clinical course of Alzheimer's disease (AD). The study points to the possibility of modest slowing of the cognitive decline in AD in a subset of patients older than 65, while at the same time highlights the risk of stimulation in exacerbation of this decline in younger patients...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27516384/comparing-neurostimulation-technologies-in-refractory-focal-onset-epilepsy
#10
Inuka Kishara Gooneratne, Alexander L Green, Patricia Dugan, Arjune Sen, Angelo Franzini, Tipu Aziz, Binith Cheeran
For patients with pharmacoresistant focal epilepsy in whom surgical resection of the epileptogenic focus fails or was not feasible in the first place, there were few therapeutic options. Increasingly, neurostimulation provides an alternative treatment strategy for these patients. Vagal nerve stimulation (VNS) is well established. Deep brain stimulation (DBS) and cortical responsive stimulation (CRS) are newer neurostimulation therapies with recently published long-term efficacy and safety data. In this literature review, we introduce these therapies to a non-specialist audience...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27508216/clinical-neuropsychological-and-pre-stimulus-dorsomedial-thalamic-nucleus-electrophysiological-data-in-deep-brain-stimulation-patients
#11
Catherine M Sweeney-Reed, Tino Zaehle, Jürgen Voges, Friedhelm C Schmitt, Lars Buentjen, Klaus Kopitzki, Alan Richardson-Klavehn, Hermann Hinrichs, Hans-Jochen Heinze, Robert T Knight, Michael D Rugg
The data presented here comprise clinical, neuropsychological, and intrathalamic electrophysiological data from 7 patients with pharmacoresistant focal epilepsy and are related to the article "Pre-stimulus thalamic theta power predicts human memory formation" C.M. Sweeney-Reed, T. Zaehle, J. Voges, F.C. Schmitt, L. Buentjen, K. Kopitzki, et al. (2016) [1]. The patients participated in a memory paradigm after receiving electrodes implanted in the DMTN due to the surgical approach taken in electrode insertion for deep brain stimulation of the anterior thalamic nucleus...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27486103/perimovement-decrease-of-alpha-beta-oscillations-in-the-human-nucleus-accumbens
#12
Max-Philipp Stenner, Stefan Dürschmid, Robb B Rutledge, Tino Zaehle, Friedhelm C Schmitt, Jörn Kaufmann, Jürgen Voges, Hans-Jochen Heinze, Raymond J Dolan, Mircea Ariel Schoenfeld
The human nucleus accumbens is thought to play an important role in guiding future action selection via an evaluation of current action outcomes. Here we provide electrophysiological evidence for a more direct, i.e., online, role during action preparation. We recorded local field potentials from the nucleus accumbens in patients with epilepsy undergoing surgery for deep brain stimulation. We found a consistent decrease in the power of alpha/beta oscillations (10-30 Hz) before and around the time of movements...
October 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27485172/thalamic-interictal-epileptiform-discharges-in-deep-brain%C3%A2-stimulated-epilepsy-patients
#13
Catherine M Sweeney-Reed, Harim Lee, Stefan Rampp, Tino Zaehle, Lars Buentjen, Juergen Voges, Martin Holtkamp, Hermann Hinrichs, Hans-Jochen Heinze, Friedhelm C Schmitt
The relationships between interictal epileptiform discharges (IEDs) in the anterior (ANT) and dorsomedial nuclei (DMNT) of the thalamus and electro-clinical parameters in pharmacoresistant focal epilepsy patients receiving intrathalamic electrodes for deep brain stimulation (DBS) were investigated. Thalamus-localized IEDs (LIEDs) and surface EEG (sEEG)-IEDs were evaluated in eight patients who underwent ANT-DBS. Occurrence and frequency of ANT- and DMNT-LIEDs and pre-operative sEEG-IEDs were examined with respect to seizure onset location and seizure outcome following ANT-DBS...
October 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27434073/clinical-outcome-of-patients-with-deep-brain-stimulation-of-the-centromedian-thalamic-nucleus-for-refractory-epilepsy-and-location-of-the-active-contacts
#14
Byung-Chul Son, Young Min Shon, Jin-Gyu Choi, Jiyeon Kim, Sang-Woo Ha, Sung-Hoon Kim, Si-Hoon Lee
OBJECTIVES: To investigate the clinical outcome of patients treated with chronic deep brain stimulation (DBS) of the centromedian nucleus (CM) for refractory epilepsy and to determine the location of active contacts. METHODS: The outcome of CM stimulation was evaluated as percent seizure reduction compared to the baseline 3 months. To establish the location of active contacts, 27 leads were studied in 14 patients with refractory epilepsy. An analysis was conducted to reveal whether any coordinates of the center of the active contacts predicted percent seizure reduction...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27411799/update-of-neurositmulation-for-refractory-epilepsy-deep-brain-stimulation-and-responsive-neurostimulation
#15
Ming-Che Kuo, Tun Jao, Horng-Huei Liu
No abstract text is available yet for this article.
March 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27398710/imaging-of-anterior-nucleus-of-thalamus-using-1-5t-mri-for-deep-brain-stimulation-targeting-in-refractory-epilepsy
#16
Elena Jiltsova, Timo Möttönen, Markus Fahlström, Joonas Haapasalo, Timo Tähtinen, Jukka Peltola, Juha Öhman, Elna-Marie Larsson, Tommi Kiekara, Kai Lehtimäki
BACKGROUND: Deep brain stimulation (DBS) of the anterior nucleus of thalamus (ANT) is an evolving treatment option in refractory focal epilepsy. Due to poor visualization of ANT in traditional MRI sequences used for movement disorder surgery, targeting of ANT is mainly based on stereotactic atlas information. Sophisticated 3T MRI methods enable visualization of ANT, but 1.5T MRI is still preferred or more readily available in a large number of centers performing DBS. OBJECTIVE: In the present study, we sought to determine whether ANT could be adequately visualized at 1...
July 11, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27384886/transcranial-direct-current-stimulation-as-treatment-in-epilepsy
#17
Markus Gschwind, Margitta Seeck
INTRODUCTION: Neuromodulation (NM) is a complementary therapy for patients with drug-resistant epilepsy. Vagal nerve stimulation and deep brain stimulation of the anterior thalamus are established techniques and have shown their efficacy in lowering seizure frequency, but they are invasive and rarely render patients seizure-free. Non-invasive NM techniques are therefore increasingly investigated in a clinical context. AREAS COVERED: Current knowledge about transcranial direct-current stimulation (tDCS) and other non-invasive NM in patients with epilepsy, based on the available animal and clinical studies from PubMed search...
July 18, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27271515/-perampanel-as-a-therapy-option-in-patients-with-epilepsy
#18
M Hintz, S Nawratil, A Schulze-Bonhage
BACKGROUND: This article describes a monocentric retrospective analysis of clinical experience with the latest antiepileptic drug perampanel with non-competitive modulation of postsynaptic AMPA receptors. MATERIAL AND METHODS: Evaluation of electronic medical charts of patients newly treated with perampanel between 2012 and 2014 at the epilepsy center of the University Hospital Freiburg regarding effectiveness and tolerability. RESULTS: A total of 85 patients (45 male, mean age 37...
August 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27234870/extra-cardiac-stimulators-what-do-cardiologists-need-to-know
#19
REVIEW
Alexandre Guinand, Stéphane Noble, Angela Frei, Julien Renard, Martin R Tramer, Haran Burri
For several decades, treating patients with pacemakers has been the privilege of cardiologists. However, in the last 30 years, researchers have found new targets for electrical stimulation in different clinical subspecialities, such as deep brain stimulation (for the treatment of Parkinson's disease, essential tremor, dystonia, and some psychiatric illnesses); spinal cord stimulation (for refractory angina, chronic pain, and peripheral artery disease); and sacral (for diverse urologic and proctologic conditions), vagal (for epilepsy), and phrenic nerve stimulation (for sleep apnoea)...
September 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27208861/pre-stimulus-thalamic-theta-power-predicts-human-memory-formation
#20
Catherine M Sweeney-Reed, Tino Zaehle, Jürgen Voges, Friedhelm C Schmitt, Lars Buentjen, Klaus Kopitzki, Alan Richardson-Klavehn, Hermann Hinrichs, Hans-Jochen Heinze, Robert T Knight, Michael D Rugg
Pre-stimulus theta (4-8Hz) power in the hippocampus and neocortex predicts whether a memory for a subsequent event will be formed. Anatomical studies reveal thalamus-hippocampal connectivity, and lesion, neuroimaging, and electrophysiological studies show that memory processing involves the dorsomedial (DMTN) and anterior thalamic nuclei (ATN). The small size and deep location of these nuclei have limited real-time study of their activity, however, and it is unknown whether pre-stimulus theta power predictive of successful memory formation is also found in these subcortical structures...
September 2016: NeuroImage
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