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Qsm iron spectroscopy

Cynthia Wisnieff, Sriram Ramanan, John Olesik, Susan Gauthier, Yi Wang, David Pitt
PURPOSE: Within multiple sclerosis (MS) lesions iron is present in chronically activated microglia. Thus, iron detection with MRI might provide a biomarker for chronic inflammation within lesions. Here, we examine contributions of iron and myelin to magnetic susceptibility of lesions on quantitative susceptibility mapping (QSM). METHODS: Fixed MS brain tissue was assessed with MRI including gradient echo data, which was processed to generate field (phase), R2* and QSM...
August 2015: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Huan Tan, Tian Liu, Ying Wu, Jon Thacker, Robert Shenkar, Abdul Ghani Mikati, Changbin Shi, Conner Dykstra, Yi Wang, Pottumarthi V Prasad, Robert R Edelman, Issam A Awad
OBJECTIVES: The aims of this study were to investigate and validate quantitative susceptibility mapping (QSM) for lesional iron quantification in cerebral cavernous malformations (CCMs). MATERIALS AND METHODS: Magnetic resonance imaging studies were performed in phantoms and 16 patients on a 3-T scanner. Susceptibility weighted imaging, QSM, and R2* maps were reconstructed from in vivo data acquired with a 3-dimensional, multi-echo, and T2*-weighted gradient echo sequence...
July 2014: Investigative Radiology
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