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Quantitative susceptibility mapping

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https://www.readbyqxmd.com/read/29774565/local-and-systemic-regulation-of-psii-efficiency-in-triticale-infected-by-the-hemibiotrophic-pathogen-microdochium-nivale
#1
Mateusz Dyda, Iwona Wąsek, Mirosław Tyrka, Maria Wędzony, Magdalena Szechyńska-Hebda
Microdochium nivale is a fungal pathogen that causes yield losses of cereals during winter. Cold hardening under light conditions induces genotype-dependent resistance of a plant to infection. We aim to show how photosystem II (PSII) regulation contributes to plant resistance. Using mapping population of triticale doubled haploid lines, three M. nivale strains and different infection assays, we demonstrate that plants that maintain a higher maximum quantum efficiency of PSII show less leaf damage upon infection...
May 17, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29764949/toward-an-improved-meningococcal-serogroup-b-assay
#2
Jan Poolman
Because of diverse sequences and differential expression of surface structures on individual invasive Neisseria meningitidis serogroup B (MenB) strains, predicting the efficacy of MenB vaccines using traditional human serum bactericidal assays (hSBA) is impractical. The meningococcal antigen surface expression (MEASURE) assay uses flow cytometry to quantitate the expression of factor H binding proteins (fHbp) contained in the bivalent rLP2086 MenB vaccine. To date, experience with MEASURE has been lacking, and in a long-awaited article, McNeil et al...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29756399/distinct-progression-pattern-of-susceptibility-mri-in-the-substantia-nigra-of-parkinson-s-patients
#3
Guangwei Du, Mechelle M Lewis, Christopher Sica, Lu He, James R Connor, Lan Kong, Richard B Mailman, Xuemei Huang
BACKGROUND: Susceptibility MRI may capture Parkinson's disease-related pathology. This study delineated longitudinal changes in different substantia nigra regions. METHODS: Seventy-two PD patients and 62 controls were studied at both baseline and after 18 months with MRI. R2* and quantitative susceptibility mapping values from the substantia nigra pars compacta and substantia nigra pars reticulata were calculated. Mixed-effects models compared controls with PD or PD subgroups having different disease durations: early (<1 year), middle (<5 years, middle-stage PD), and late (>5 years, late-stage PD)...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29756231/susceptibility-mri-captures-nigral-pathology-in-patients-with-parkinsonian-syndromes
#4
Mechelle M Lewis, Guangwei Du, Jennifer Baccon, Amanda M Snyder, Ben Murie, Felicia Cooper, Christy Stetter, Lan Kong, Christopher Sica, Richard B Mailman, James R Connor, Xuemei Huang
BACKGROUND: Parkinsonisms are neurodegenerative disorders characterized pathologically by α-synuclein-positive (e.g., PD, diffuse Lewy body disease, and MSA) and/or tau-positive (e.g., PSP, cortical basal degeneration) pathology. Using R2* and quantitative susceptibility mapping, susceptibility changes have been reported in the midbrain of living parkinsonian patients, although the exact underlying pathology of these alterations is unknown. OBJECTIVE: The current study investigated the pathological correlates of these susceptibility MRI measures...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29746715/quantitative-susceptibility-map-analysis-in-preterm-neonates-with-germinal-matrix-intraventricular-hemorrhage
#5
Domenico Tortora, Mariasavina Severino, Jan Sedlacik, Benedetta Toselli, Mariya Malova, Alessandro Parodi, Giovanni Morana, Marco Massimo Fato, Luca Antonio Ramenghi, Andrea Rossi
BACKGROUND: Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common form of intracranial hemorrhage occurring in preterm neonates that may affect normal brain development. Although the primary lesion is easily identified on MRI by the presence of blood products, its exact extent may not be recognizable with conventional sequences. Quantitative susceptibility mapping (QSM) quantify the spatial distribution of magnetic susceptibility within biological tissues, including blood degradation products...
May 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29743622/genetic-mapping-identifies-loci-that-influence-tomato-resistance-against-colorado-potato-beetles
#6
Erandi Vargas-Ortiz, Itay Gonda, John R Smeda, Martha A Mutschler, James J Giovannoni, Georg Jander
The Colorado potato beetle (CPB; Leptinotarsa decemlineata Say), the most economically important insect pest on potato (Solanum tuberosum L.), also feeds on other Solanaceae, including cultivated tomato (Solanum lycopersicum L.). We used tomato genetic mapping populations to investigate natural variation in CPB resistance. CPB bioassays with 74 tomato lines carrying introgressions of Solanum pennellii in S. lycopersicum cv. M82 identified introgressions from S. pennellii on chromosomes 1 and 6 conferring CPB susceptibility, whereas introgressions on chromosomes 1, 8 and 10 conferred higher resistance...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738526/morphology-adaptive-total-variation-for-the-reconstruction-of-quantitative-susceptibility-map-from-the-magnetic-resonance-imaging-phase
#7
Li Guo, Yingjie Mei, Jijing Guan, Xiangliang Tan, Yikai Xu, Wufan Chen, Qianjin Feng, Yanqiu Feng
Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging technique that quantifies the magnetic susceptibility distribution within biological tissues. QSM calculates the underlying magnetic susceptibility by deconvolving the tissue magnetic field map with a unit dipole kernel. However, this deconvolution problem is ill-posed. The morphology enabled dipole inversion (MEDI) introduces total variation (TV) to regularize the susceptibility reconstruction. However, MEDI results still contain artifacts near tissue boundaries because MEDI only imposes TV constraint on voxels inside smooth regions...
2018: PloS One
https://www.readbyqxmd.com/read/29737851/large-scale-label-free-quantitative-mapping-of-the-sputum-proteome
#8
James P R Schofield, Dominic Burg, Joost Brandsma, Doroteya Staykova, Caterina Folisi, Aruna Bansal, Ben Nicholas, Yang Xian, Anthony Rowe, Julie Corfield, Susan Wilson, Jonathan Ward, Rene Lutter, Louise Fleming, Dominick E Shaw, Per S Bakke, Massimo Caruso, Sven-Erik Dahlén, Stephen J Fowler, Simone Hashimoto, Ildiko Horvath, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandstrom, Florian Singer, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R Sousa, Ian M Adcock, Kian Fan Chung, Peter J Sterk, Ratko Djukanovic, Paul J Skipp
Analysis of induced sputum supernatant is a minimally invasive approach to study the epithelial lining fluid and, thereby, provide insight into normal lung biology and the pathobiology of lung diseases. We present here a novel proteomics approach to sputum analysis developed within the U-BIOPRED (Unbiased BIOmarkers Predictive of REspiratory Disease outcomes) international project. We present practical and analytical techniques to optimise the detection of robust biomarkers in proteomic studies. The normal sputum proteome was derived using data-independent HDMSE applied to 40 healthy non-smoking participants, which provides an essential baseline from which to compare modulation of protein expression in respiratory diseases...
May 8, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29737402/gwas-analysis-using-interspecific-backcross-progenies-reveals-superior-blue-catfish-alleles-responsible-for-strong-resistance-against-enteric-septicemia-of-catfish
#9
Suxu Tan, Tao Zhou, Wenwen Wang, Yulin Jin, Xiaozhu Wang, Xin Geng, Jian Luo, Zihao Yuan, Yujia Yang, Huitong Shi, Dongya Gao, Rex Dunham, Zhanjiang Liu
Infectious diseases pose significant threats to the catfish industry. Enteric septicemia of catfish (ESC) caused by Edwardsiella ictaluri is the most devastating disease for catfish aquaculture, causing huge economic losses annually. Channel catfish and blue catfish exhibit great contrast in resistance against ESC, with channel catfish being highly susceptible and blue catfish being highly resistant. As such, the interspecific backcross progenies provide an ideal system for the identification of quantitative trait locus (QTL)...
May 8, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29730126/lorentzian-effects-in-magnetic-susceptibility-mapping-of-anisotropic-biological-tissues
#10
Dmitriy A Yablonskiy, Alexander L Sukstanskii
The ultimate goal of MRI is to provide information on biological tissue microstructure and function. Quantitative Susceptibility Mapping (QSM) is one of the newer approaches for studying tissue microstructure by means of measuring phase of Gradient Recalled Echo (GRE) MRI signal. The fundamental question in the heart of this approach is: what is the relationship between the net phase/frequency of the GRE signal from an imaging voxel and the underlying tissue microstructure at the cellular and sub-cellular levels? In the presence of external magnetic field, biological media (e...
April 26, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29729391/in-vivo-quantitative-structural-imaging-of-the-human-midbrain-and-the-superior-colliculus-at-9-4t
#11
Joana R Loureiro, Marc Himmelbach, Thomas Ethofer, Rolf Pohmann, Pascal Martin, Jonas Bause, Klaus Scheffler, Wolfgang Grodd, Gisela E Hagberg
We explored anatomical details of the superior colliculus (SC) by in vivo magnetic resonance imaging (MRI) at 9.4T. The high signal-to-noise ratio allowed the acquisition of high resolution, multi-modal images with voxel sizes ranging between 176 × 132 × 600 μm and (800)3 μm. Quantitative mapping of the longitudinal relaxation rate R1, the effective transverse relaxation rate R2*, and the magnetic susceptibility QSM was performed in 14 healthy volunteers. The images were analyzed in native space as well as after normalization to a common brain space (MNI)...
May 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29722955/increased-iron-deposition-on-brain-quantitative-susceptibility-mapping-correlates-with-decreased-cognitive-function-in-alzheimer-s-disease
#12
Lei Du, Zifang Zhao, Ailing Cui, Yijiang Zhu, Lu Zhang, Jing Liu, Sumin Shi, Chao Fu, Xiaowei Han, Wenwen Gao, Tianbin Song, Lizhi Xie, Lei Wang, Shilong Sun, Runcai Guo, Guolin Ma
The excessive accumulation of iron in deep gray structures is an important pathological characteristic in patients with Alzheimer's disease (AD). Quantitative susceptibility mapping (QSM) is more specific than other imaging-based iron measurements modalities and allows non-invasively assessment of tissue magnetic susceptibility, which has been shown to correlate well to the brain iron levels. This study aimed to investigate the correlations between the magnetic susceptibility values of deep gray matter nuclei and the cognitive functions assessed by mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) in patients with the mild and moderate AD...
May 3, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29702183/quantifying-iron-content-in-magnetic-resonance-imaging
#13
Kiarash Ghassaban, Saifeng Liu, Caihong Jiang, E Mark Haacke
Measuring iron content has practical clinical indications in the study of diseases such as Parkinson's disease, Huntington's disease, ferritinopathies and multiple sclerosis as well as in the quantification of iron content in microbleeds and oxygen saturation in veins. In this work, we review the basic concepts behind imaging iron using T2, T2*, T2', phase and quantitative susceptibility mapping in the human brain, liver and heart, followed by the applications of in vivo iron quantification in neurodegenerative diseases, iron tagged cells and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles...
April 24, 2018: NeuroImage
https://www.readbyqxmd.com/read/29696532/quantitative-dynamic-susceptibility-contrast-perfusion-weighted-imaging-guided-customized-gamma-knife-re-irradiation-of-recurrent-high-grade-gliomas
#14
Bao Wang, Peng Zhao, Yi Zhang, Mingxu Ge, Chuanjin Lan, Chuanting Li, Qi Pang, Shangchen Xu, Yingchao Liu
INTRODUCTION: Treatment of recurrent high-grade gliomas (rHGG) has always been challenging. This study aimed to explore the treatment effect of quantitative dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI)-guided gamma knife radiosurgery (GKRS) on rHGG. METHODS: Between April 2014 and July 2016, 26 consecutive patients were treated by quantitative DSC-PWI-guided GKRS as salvage treatment for rHGG. The gross tumor volume (GTV) was defined as the high perfusion area on absolute cerebral blood volume maps, with a cutoff value of 22 ml/100 g...
April 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29696297/mapping-and-characterization-of-the-new-adult-plant-leaf-rust-resistance-gene-lr77-derived-from-santa-fe-winter-wheat
#15
James A Kolmer, Zhenqi Su, Amy Bernardo, Guihua Bai, Shiaoman Chao
A new gene for adult plant leaf rust resistance in wheat was mapped to chromosome 3BL. This gene was designated as Lr77. 'Santa Fe' is a hard red winter cultivar that has had long-lasting resistance to the leaf rust fungus, Puccinia triticina. The objective of this study was to determine the chromosome location of the adult plant leaf rust resistance in Santa Fe wheat. A partial backcross line of 'Thatcher' (Tc) wheat with adult plant leaf rust resistance derived from Santa Fe was crossed with Thatcher to develop a Thatcher//Tc*2/Santa Fe F6 recombinant inbred line (RIL) population...
April 25, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29695719/the-multiple-myeloma-risk-allele-at-5q15-lowers-ell2-expression-and-increases-ribosomal-gene-expression
#16
Mina Ali, Ram Ajore, Anna-Karin Wihlborg, Abhishek Niroula, Bhairavi Swaminathan, Ellinor Johnsson, Owen W Stephens, Gareth Morgan, Tobias Meissner, Ingemar Turesson, Hartmut Goldschmidt, Ulf-Henrik Mellqvist, Urban Gullberg, Markus Hansson, Kari Hemminki, Hareth Nahi, Anders Waage, Niels Weinhold, Björn Nilsson
Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138+ plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expression in these cells (Pcombined  = 2.5 × 10-27 ; βcombined  = -0.24 SD), but not in peripheral blood or other tissues. Consistent with this, several variants representing the MM risk allele map to regulatory genomic regions, and three yield reduced transcriptional activity in plasmocytoma cell lines...
April 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29694896/high-dimensional-phenotyping-identifies-age-emergent-cells-in-human-mammary-epithelia
#17
Fanny A Pelissier Vatter, Denis Schapiro, Hang Chang, Alexander D Borowsky, Jonathan K Lee, Bahram Parvin, Martha R Stampfer, Mark A LaBarge, Bernd Bodenmiller, James B Lorens
Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished tumor-suppressive cell types and the accumulation of defective epithelial progenitors. Quantitative characterization of these age-emergent human cell subpopulations is lacking, impeding our understanding of the relationship between age and cancer susceptibility. We conducted single-cell resolution proteomic phenotyping of healthy breast epithelia from 57 women, aged 16-91 years, using mass cytometry...
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29694688/quantitative-susceptibility-mapping-and-23-na-imaging-based-in-vitro-characterization-of-blood-clotting-kinetics
#18
Till M Schneider, Armin M Nagel, Markus Zorn, Andreas Wetscherek, Martin Bendszus, Mark E Ladd, Sina Straub
Blood clotting is a fundamental biochemical process in post-hemorrhagic hemostasis. Although the varying appearance of coagulating blood in T1 - and T2 -weighted images is widely used to qualitatively determine bleeding age, the technique permits only a rough discrimination of coagulation stages, and it remains difficult to distinguish acute and chronic hemorrhagic stages because of low T1 - and T2 -weighted signal intensities in both instances. To investigate new biomedical parameters for magnetic resonance imaging-based characterization of blood clotting kinetics, sodium imaging and quantitative susceptibility mapping (QSM) were compared with conventional T1 - and T2 -weighted imaging, as well as with biochemical hemolysis parameters...
April 25, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29687923/quantitative-susceptibility-mapping-of-articular-cartilage-ex-vivo-findings-at-multiple-orientations-and-following-different-degradation-treatments
#19
Olli Nykänen, Lassi Rieppo, Juha Töyräs, Ville Kolehmainen, Simo Saarakkala, Karin Shmueli, Mikko J Nissi
PURPOSE: We investigated the feasibility of quantitative susceptibility mapping (QSM) for assessing degradation of articular cartilage by measuring ex vivo bovine cartilage samples subjected to different degradative treatments. Specimens were scanned at several orientations to study if degradation affects the susceptibility anisotropy. T2*-mapping, histological stainings, and polarized light microscopy were used as reference methods. Additionally, simulations of susceptibility in layered geometry were performed...
April 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29680862/staygreen-cssgr-is-a-candidate-for-the-anthracnose-colletotrichum-orbiculare-resistance-locus-cla-in-gy14-cucumber
#20
Junsong Pan, Junyi Tan, Yuhui Wang, Xiangyang Zheng, Ken Owens, Dawei Li, Yuhong Li, Yiqun Weng
Map-based cloning identified a candidate gene for resistance to the anthracnose fungal pathogen Colletotrichum orbiculare in cucumber, which reveals a novel function for the highly conserved STAYGREEN family genes for host disease resistance in plants. Colletotrichum orbiculare is a hemibiotrophic fungal pathogen that causes anthracnose disease in cucumber and other cucurbit crops. No host resistance genes against the anthracnose pathogens have been cloned in crop plants. Here, we reported fine mapping and cloning of a resistance gene to the race 1 anthracnose pathogen in cucumber inbred lines Gy14 and WI 2757...
April 21, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
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