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https://www.readbyqxmd.com/read/29845939/outpatient-clinic-for-users-of-anabolic-androgenic-steroids-an-overview
#1
D L Smit, W de Ronde
BACKGROUND: Anabolic androgenic steroids (AAS) are used by approximately 20,000 amateur athletes in the Netherlands. AAS are harmful but data are lacking as to precisely how harmful they are. An outpatient clinic for past and current users of AAS was established in 2011 to acquire more knowledge about the health risks associated with AAS abuse. METHODS: All case files of the patients who visited the AAS clinic were reviewed retrospectively. RESULTS: 180 patients visited the AAS clinic between May 2011 and May 2016...
May 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29734624/the-consequences-of-exposure-to-mixtures-of-chemicals-something-from-nothing-and-a-lot-from-a-little-when-fish-are-exposed-to-steroid-hormones
#2
Tara J Thrupp, Tamsin J Runnalls, Martin Scholze, Subramaniam Kugathas, Andreas Kortenkamp, John P Sumpter
Ill-defined, multi-component mixtures of steroidal pharmaceuticals are present in the aquatic environment. Fish are extremely sensitive to some of these steroids. It is important to know how fish respond to these mixtures, and from that knowledge develop methodology that enables accurate prediction of those responses. To provide some of the data required to reach this objective, pairs of fish were first exposed to five different synthetic steroidal pharmaceuticals (one estrogen, EE2; one androgen, trenbolone; one glucocorticoid, beclomethasone dipropionate; and two progestogens, desogestrel and levonorgestrel) and concentration-response data on egg production obtained...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29722624/cross-talk-between-androgen-and-wnt-signaling-potentially-contributes-to-age-related-skeletal-muscle-atrophy-in-rats
#3
Petey W Mumford, Matthew A Romero, Xuansong Mao, C Brooks Mobley, Wesley C Kephart, Cody T Haun, Paul A Roberson, Kaelin C Young, Jeffrey S Martin, Joshua F Yarrow, Darren T Beck, Michael D Roberts
We sought to determine whether age-related gastrocnemius muscle mass loss was associated with parallel decrements in androgen receptor (AR) or select Wnt signaling markers. To test this hypothesis, serum free and total testosterone (TEST) as well as gastrocnemius AR and Wnt signaling markers were analyzed in male Fischer 344 rats that were 3/6/12/18 and 24 months (mo) old (n=9 per group). Free and total TEST were greatest in 6 mo rats, and AR protein and Wnt5 protein levels linearly declined with aging. There were associations between Wnt5 protein levels and relative gastrocnemius mass (r=0...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29701261/a-critical-review-of-the-environmental-occurrence-and-potential-effects-in-aquatic-vertebrates-of-the-potent-androgen-receptor-agonist-17%C3%AE-trenbolone
#4
REVIEW
Gerald T Ankley, Katherine K Coady, Melanie Gross, Henrik Holbech, Steven L Levine, Gerd Maack, Mike Williams
Trenbolone acetate is widely-used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17β-trenbolone (βTRB), have been detected in at low ng/L concentrations in surface waters associated with animal feedlots. The βTRB isomer can affect androgen receptor (AR) signaling pathways in various vertebrate species at comparatively low concentrations/doses. This paper provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of βTRB, with an emphasis on potential risks to aquatic animals...
April 27, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29659862/effects-of-hormonal-growth-promotants-on-beef-quality-a-meta-analysis
#5
I J Lean, H M Golder, N M Lees, P McGilchrist, J E P Santos
Background: Benefits of hormonal growth promotants (HGP) include production efficiency, profit, and reduced environmental effects for beef cattle. Questions remain about effects of HGP on beef quality, particularly on measures of toughness such as Warner-Bratzler shear force (WBSF), tenderness, and other taste-panel attributes of beef. Objective: To assess the effects of HGP on beef quality using the results of randomized controlled trials. Design: Searches of 3 databases...
April 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29547853/occurrence-fate-and-risk-assessment-of-androgens-in-ten-wastewater-treatment-plants-and-receiving-rivers-of-south-china
#6
Jin-Na Zhang, Guang-Guo Ying, Yuan-Yuan Yang, Wang-Rong Liu, Shuang-Shuang Liu, Jun Chen, You-Sheng Liu, Jian-Liang Zhao, Qian-Qian Zhang
Androgens are one class of steroids that could cause endocrine disrupting effects in aquatic organisms. However, little information is available about androgens in wastewater treatment plants (WWTPs) with different treatment technologies. Here we investigated the occurrence, removal, and fate of fourteen natural and synthetic androgens in ten WWTPs of Guangdong province, south China. The results showed detection of ten androgens in the influents of the ten WWTPs, with concentrations up to 4650 ng/L (androsta-1,4-diene-3,17-dione)...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29534183/evaluation-of-coated-steroidal-implants-containing-trenbolone-acetate-and-estradiol-17%C3%AE-on-live-performance-carcass-traits-and-sera-metabolites-in-finishing-steers
#7
Zachary K Smith, Alex J Thompson, John P Hutcheson, Wade T Nichols, Bradley J Johnson
Crossbred beef steers (n = 240; 12 pens/treatment; initial BW = 305 ± 17.7 kg) were used in a randomized block design feedlot study to evaluate the influence of coated trenbolone acetate (TBA) and estradiol-17β (E2) implants (Merck Animal Health, Madison, NJ) on gain performance, carcass traits, and sera metabolites. The five treatments were no implant (NI), Revalor-XR on d 0 [200 mg TBA + 20 mg E2 (coated); XR], Revalor-XS on d 0 [200 mg TBA + 40 mg E2 (total): 80 mg TBA + 16 mg E2 (noncoated) and 120 mg TBA + 24 mg E2 (coated); XS], Revalor-200 on d 0 [200 mg TBA + 20 mg E2 (noncoated); E200], or Revalor-200 on d 70 (D200)...
May 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29477864/an-endocrine-disrupting-agricultural-contaminant-impacts-sequential-female-mate-choice-in-fish
#8
Patrick Tomkins, Minna Saaristo, Michael G Bertram, Marcus Michelangeli, Raymond B Tomkins, Bob B M Wong
The environmental impact of endocrine-disrupting chemicals (EDCs)-compounds that interfere with endocrine system function at minute concentrations-is now well established. In recent years, concern has been mounting over a group of endocrine disruptors known as hormonal growth promotants (HGPs), which are natural and synthetic chemicals used to promote growth in livestock by targeting the endocrine system. One of the most potent compounds to enter the environment as a result of HGP use is 17β-trenbolone, which has repeatedly been detected in aquatic habitats...
June 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29421751/veterinary-drug-17%C3%AE-trenbolone-promotes-the-proliferation-of-human-prostate-cancer-cell-line-through-the-akt-ar-signaling-pathway
#9
Hee-Seok Lee, Da-Woon Jung, Songyi Han, Hui-Seung Kang, Jin-Hyang Suh, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
Trenbolone acetate (TBA) is a synthetic anabolic steroidal growth factor that is used for rapid muscle development in cattle. The absorbed TBA is hydrolyzed to the active form, 17β-trenbolone (17 TB; 17β-hydroxy-estra-4,9,11-trien-3-one) in meat and milk products, which can cause adverse health effects in humans. Similar to 5α-dihydrotestosterone (DHT), 17 TB was reported to exhibit endocrine disrupting effects on animals and humans due to its androgenic effect via binding to the androgen receptor. The purpose of this study is to investigate the molecular mechanism of cell proliferation in prostate cancer (PCa) cells treated with 17 TB...
May 2018: Chemosphere
https://www.readbyqxmd.com/read/28857258/summary-of-the-development-the-us-environmental-protection-agency-s-medaka-extended-one-generation-reproduction-test-meogrt-using-data-from-9-multigenerational-medaka-tests
#10
Kevin Flynn, Doug Lothenbach, Frank Whiteman, Dean Hammermeister, Leslie W Touart, Joe Swintek, Norihisa Tatarazako, Yuta Onishi, Taisen Iguchi, Rodney Johnson
In response to various legislative mandates, the US Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, formed the basis of a tiered testing strategy to determine the potential of pesticides, commercial chemicals, and environmental contaminants to disrupt the endocrine system. The first tier of tests is intended to detect the potential for endocrine disruption mediated through estrogen, androgen, or thyroid pathways, whereas the second tier is intended to further characterize the effects on these pathways and to establish a dose-response relationship for adverse effects...
December 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28854383/the-agricultural-contaminant-17%C3%AE-trenbolone-disrupts-male-male-competition-in-the-guppy-poecilia-reticulata
#11
Patrick Tomkins, Minna Saaristo, Michael G Bertram, Raymond B Tomkins, Mayumi Allinson, Bob B M Wong
Despite a growing literature highlighting the potential impact of human-induced environmental change on mechanisms of sexual selection, relatively little is known about the effects of chemical pollutants on male-male competition. One class of environmental pollutant likely to impact male competitive interactions is the endocrine-disrupting chemicals (EDCs), a large and heterogeneous group of chemical contaminants with the potential to influence morphology, physiology and behaviour at minute concentrations. One EDC of increasing concern is the synthetic, androgenic steroid 17β-trenbolone, which is used globally to promote growth in beef cattle...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28648787/online-turbulent-flow-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry-for-high-throughput-screening-of-anabolic-steroids-in-horse-urine
#12
Hyun Du Shin, Joon Hyuk Suh, Junghyun Kim, Hyun-Deok Cho, Su Duk Lee, Kwan Seok Han, Yu Wang, Sang Beom Han
A high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine by online turbulent flow extraction coupled with liquid chromatography-tandem mass spectrometry was developed. The use of turbulent flow chromatography could simplify pretreatment of horse urine, which has complex matrices as well as high viscosity...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28549324/salinity-and-sensitivity-to-endocrine-disrupting-chemicals-a-comparison-of-reproductive-endpoints-in-small-bodied-fish-exposed-under-different-salinities
#13
REVIEW
Thijs Bosker, Giacomo Santoro, Steven D Melvin
The influence of salinity on toxicity outcomes has been demonstrated for various contaminants, but has received limited attention for endocrine disrupting chemicals (EDCs). Short-term laboratory tests using small-bodied fish are an important tool for evaluating impacts of EDCs on reproduction. Tests have been developed for both freshwater and estuarine/marine species, providing an opportunity to assess whether concentrations at which small-bodied fish respond to EDCs may be influenced by salinity. We conducted a semi-quantitative review of short-term laboratory tests with small-bodied fish exposed to EDCs, including 59 studies under freshwater conditions (7 species) and 23 studies conducted under saline conditions (5 species)...
September 2017: Chemosphere
https://www.readbyqxmd.com/read/28380538/anabolic-payout-of-terminal-implant-alters-adipogenic-gene-expression-of-the-longissimus-muscle-in-beef-steers
#14
RANDOMIZED CONTROLLED TRIAL
Z K Smith, K Y Chung, S L Parr, B J Johnson
This experiment evaluated the dose and payout pattern of trenbolone acetate (TBA) and estradiol-17β (E) on LM mRNA expression of adenosine monophosphate-activated protein kinase-ɑ (-ɑ), β, G protein-coupled receptor 41(), G protein-coupled receptor 43 (), γ, and stearoyl CoA desaturase () in finishing feedlot steers as indicators of adipogenesis and marbling development. British × Continental steers (n = 168; 14 pens/treatment; initial BW = 362 kg) were used in a randomized complete block design. Treatments included: no implant (NI), Revalor-S (REV-S; 120 mg TBA + 24 mg E), or Revalor-XS (REV-X; delayed release implant: 80 mg TBA + 16 mg E [uncoated], 120 mg TBA + 24 mg E [coated], 200 mg TBA + 40 mg E [total])...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28380530/effects-of-anabolic-implants-and-ractopamine-hcl-on-muscle-fiber-morphometrics-collagen-solubility-and-tenderness-of-beef-longissimus-lumborum-steaks
#15
S M Ebarb, K J Phelps, J S Drouillard, K R Maddock-Carlin, M A Vaughn, D D Burnett, J A Noel, C L Van Bibber-Krueger, C B Paulk, D M Grieger, J M Gonzalez
The objective of this study was to examine the effects of growth-promoting technologies (GP) and postmortem aging on longissimus lumborum muscle fiber cross-sectional area (CSA), collagen solubility, and their relationship to meat tenderness. Two groups of black-hided crossbred feedlot heifers (group 1: = 33, initial BW 430 ± 7 kg; group 2: = 32, initial BW 466 ± 7 kg) were blocked by BW and assigned to 1 of 3 treatments consisting of: no implant and no ractopamine hydrochloride (CON; = 21); implant, no ractopamine hydrochloride (IMP; = 22); implant and ractopamine hydrochloride (COMBO; = 22)...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28372163/abuse-of-anabolic-agents-in-beef-cattle-could-bile-be-a-possible-alternative-matrix
#16
Francesca Lega, Roberto Angeletti, Roberto Stella, Lorenzo Rigoni, Giancarlo Biancotto, Danilo Giusepponi, Simone Moretti, Giorgio Saluti, Roberta Galarini
European Union prohibited the use of anabolic agents in food producing animals since 1988. An efficient control of abuses is guaranteed not only by highly performing analytical methods, but also by knowledge of metabolic pathways, kinetics of elimination and tissue distribution. To obtain data concerning metabolites production and accumulation in bile, two typical growth promoting treatments are carried out in cattle. In the first study, sixteen beef cattle were implanted with trenbolone acetate and estradiol...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28236045/detection-and-quantification-of-12-anabolic-steroids-and-analogs-in-human-whole-blood-and-20-in-hair-using-lc-hrms-ms-application-to-real-cases
#17
Nicolas Fabresse, Stanislas Grassin-Delyle, Isabelle Etting, Jean-Claude Alvarez
We developed and validated a method to detect and quantify 12 anabolic steroids in blood (androstenedione, dihydrotestosterone, boldenone, epitestosterone, mesterolone, methandienone, nandrolone, stanozolol, norandrostenedione, tamoxifene, testosterone, trenbolone) and eight more in hair samples (nandrolone phenylpropionate, nandrolone decanoate, testosterone propionate, testosterone benzoate, testosterone cypionate, testosterone decanoate, testosterone phenylpropionate, testosterone undecanoate) using liquid chromatography coupled to high-resolution mass spectrometry...
July 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28168557/validation-of-the-oecd-reproduction-test-guideline-with-the-new-zealand-mudsnail-potamopyrgus-antipodarum-using-trenbolone-and-prochloraz
#18
Cornelia Geiß, Katharina Ruppert, Clare Askem, Carlos Barroso, Daniel Faber, Virginie Ducrot, Henrik Holbech, Thomas H Hutchinson, Paula Kajankari, Karin Lund Kinnberg, Laurent Lagadic, Peter Matthiessen, Steve Morris, Maurine Neiman, Olli-Pekka Penttinen, Paula Sanchez-Marin, Matthias Teigeler, Lennart Weltje, Jörg Oehlmann
The Organisation for Economic Cooperation and Development (OECD) provides several standard test methods for the environmental hazard assessment of chemicals, mainly based on primary producers, arthropods, and fish. In April 2016, two new test guidelines with two mollusc species representing different reproductive strategies were approved by OECD member countries. One test guideline describes a 28-day reproduction test with the parthenogenetic New Zealand mudsnail Potamopyrgus antipodarum. The main endpoint of the test is reproduction, reflected by the embryo number in the brood pouch per female...
April 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28127947/recommended-approaches-to-the-scientific-evaluation-of-ecotoxicological-hazards-and-risks-of-endocrine-active-substances
#19
Peter Matthiessen, Gerald T Ankley, Ronald C Biever, Poul Bjerregaard, Christopher Borgert, Kristin Brugger, Amy Blankinship, Janice Chambers, Katherine K Coady, Lisa Constantine, Zhichao Dang, Nancy D Denslow, David A Dreier, Steve Dungey, L Earl Gray, Melanie Gross, Patrick D Guiney, Markus Hecker, Henrik Holbech, Taisen Iguchi, Sarah Kadlec, Natalie K Karouna-Renier, Ioanna Katsiadaki, Yukio Kawashima, Werner Kloas, Henry Krueger, Anu Kumar, Laurent Lagadic, Annegaaike Leopold, Steven L Levine, Gerd Maack, Sue Marty, James Meador, Ellen Mihaich, Jenny Odum, Lisa Ortego, Joanne Parrott, Daniel Pickford, Mike Roberts, Christoph Schaefers, Tamar Schwarz, Keith Solomon, Tim Verslycke, Lennart Weltje, James R Wheeler, Mike Williams, Jeffrey C Wolf, Kunihiko Yamazaki
A SETAC Pellston Workshop(®) "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review...
March 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28127424/the-cost-of-seeking-an-edge-recurrent-renal-infarction-in-setting-of-recreational-use-of-anabolic-steroids
#20
Shaun Colburn, W Kurtis Childers, Alex Chacon, Alexa Swailes, Fauzan M Ahmed, Rajinder Sahi
INTRODUCTION: Anabolic-androgenic steroid (AAS) use and testosterone therapy have been well established risk factors for the creation of a pro-thrombotic state, and to precipitate formation of thromboemboli in individuals already predisposed to thrombosis. CASE REPORT: Here, we present the case of an amateur bodybuilder, with a negative thrombophilia workup, who experienced primary renal infarction while using the AAS trenbolone acetate and testosterone, as well as a subsequent renal infarction while anticoagulated with apixaban...
February 2017: Annals of Medicine and Surgery
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