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https://www.readbyqxmd.com/read/28168557/validation-of-the-oecd-reproduction-test-guideline-with-the-new-zealand-mudsnail-potamopyrgus-antipodarum-using-trenbolone-and-prochloraz
#1
Cornelia Geiß, Katharina Ruppert, Clare Askem, Carlos Barroso, Daniel Faber, Virginie Ducrot, Henrik Holbech, Thomas H Hutchinson, Paula Kajankari, Karin Lund Kinnberg, Laurent Lagadic, Peter Matthiessen, Steve Morris, Maurine Neiman, Olli-Pekka Penttinen, Paula Sanchez-Marin, Matthias Teigeler, Lennart Weltje, Jörg Oehlmann
The Organisation for Economic Cooperation and Development (OECD) provides several standard test methods for the environmental hazard assessment of chemicals, mainly based on primary producers, arthropods, and fish. In April 2016, two new test guidelines with two mollusc species representing different reproductive strategies were approved by OECD member countries. One test guideline describes a 28-day reproduction test with the parthenogenetic New Zealand mudsnail Potamopyrgus antipodarum. The main endpoint of the test is reproduction, reflected by the embryo number in the brood pouch per female...
February 6, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28127947/recommended-approaches-to-the-scientific-evaluation-of-ecotoxicological-hazards-and-risks-of-endocrine-active-substances
#2
Peter Matthiessen, Gerald T Ankley, Ronald C Biever, Poul Bjerregaard, Christopher Borgert, Kristin Brugger, Amy Blankinship, Janice Chambers, Katherine K Coady, Lisa Constantine, Zhichao Dang, Nancy D Denslow, David A Dreier, Steve Dungey, L Earl Gray, Melanie Gross, Patrick D Guiney, Markus Hecker, Henrik Holbech, Taisen Iguchi, Sarah Kadlec, Natalie K Karouna-Renier, Ioanna Katsiadaki, Yukio Kawashima, Werner Kloas, Henry Krueger, Anu Kumar, Laurent Lagadic, Annegaaike Leopold, Steven L Levine, Gerd Maack, Sue Marty, James Meador, Ellen Mihaich, Jenny Odum, Lisa Ortego, Joanne Parrott, Daniel Pickford, Mike Roberts, Christoph Schaefers, Tamar Schwarz, Keith Solomon, Tim Verslycke, Lennart Weltje, James R Wheeler, Mike Williams, Jeffrey C Wolf, Kunihiko Yamazaki
A SETAC Pellston Workshop(®) "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review...
January 27, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28127424/the-cost-of-seeking-an-edge-recurrent-renal-infarction-in-setting-of-recreational-use-of-anabolic-steroids
#3
Shaun Colburn, W Kurtis Childers, Alex Chacon, Alexa Swailes, Fauzan M Ahmed, Rajinder Sahi
INTRODUCTION: Anabolic-androgenic steroid (AAS) use and testosterone therapy have been well established risk factors for the creation of a pro-thrombotic state, and to precipitate formation of thromboemboli in individuals already predisposed to thrombosis. CASE REPORT: Here, we present the case of an amateur bodybuilder, with a negative thrombophilia workup, who experienced primary renal infarction while using the AAS trenbolone acetate and testosterone, as well as a subsequent renal infarction while anticoagulated with apixaban...
February 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28108667/effects-on-circulating-steroid-hormones-and-gene-expression-along-the-hypothalamus-pituitary-gonadal-axis-in-adult-japanese-quail-exposed-to-17%C3%AE-trenbolone-across-multiple-generations
#4
Natalie K Karouna-Renier, Yu Chen, Paula F P Henry, Catherine M Maddox, Daniel T Sprague
We investigated the effects of the androgenic growth promoter 17ß-trenbolone (17βTB) on adult Japanese quail (Coturnix japonica) exposed across three generations. The F0 generation was exposed after sexual maturity to 0, 1, 5, 10, 20, and 40 ppm through feed. The F1 generation was exposed in ovo by maternal transfer and through feed at the same doses as their parents. The F2 generation was exposed in ovo only. Levels of plasma sex steroids, gonadal Cytochrome P450 aromatase (CYP19A1) mRNA and select brain neuroendocrine peptide mRNAs were measured...
January 20, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28074716/semiquantitative-immunohistochemical-detection-of-progesterone-receptors-in-male-accessory-sex-glands-as-a-screening-assay-for-anabolic-steroid-use-in-bulls
#5
Claudia Zanardello, Katia Capello, Roberto Stella, Giancarlo Biancotto, Marta Vascellari
We investigated the immunohistochemical expression of progesterone receptors (PRs) in the prostate and bulbourethral glands of thirty-two 10-14-mo-old Charolais bulls following treatment with a low dosage of estrogens. Animals were divided into 2 groups: 16 animals (group T) were treated for 71 d with a therapeutic dose of trenbolone acetate and estradiol by subcutaneous implant, 16 animals (group C) received no treatment. Urine samples were collected both at the beginning of the trial and 9 times during the study...
January 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28052490/population-relevant-endpoints-in-the-evaluation-of-endocrine-active-substances-eas-for-ecotoxicological-hazard-and-risk-assessment
#6
Mary S Marty, Amy Blankinship, Janice Chambers, Lisa Constantine, Werner Kloas, Anupama Kumar, Laurent Lagadic, James Meador, Daniel Pickford, Tamar Schwarz, Tim Verslycke
For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible linkage to a population-relevant adverse effect. Current ecotoxicity test methods mostly incorporate apical endpoints although some also include mechanistic endpoints, subcellular-through-organ-level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population-level effects is often unclear. The case studies of endocrine-active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated for the SETAC Pellston Workshop™: Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Chemicals were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine disruptor frameworks such as the OECD Conceptual Framework for Testing and Assessment of Endocrine Disruptors...
January 4, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/27993082/stereoselective-degradation-of-estradiol-and-trenbolone-isomers-in-alluvial-sediment
#7
Yun Zhang, Daniel D Snow, Shannon L Bartelt-Hunt
Stereoisomers of estradiol (E2) or trenbolone (TB) can occur together in the environment receiving human or livestock wastes. However, the effect of their co-occurrence on persistence has not been well elucidated. A sandy and a silt loam sediment were used to establish microcosms with α- and β-isomers of E2 or TB spiked individually and together. Sediments were sampled periodically and analyzed for E2 and TB isomers and their transformation products using derivatization gas chromatography-mass spectrometry...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27958649/sorption-and-desorption-of-17%C3%AE-trenbolone-and-trendione-on-five-soils
#8
Joseph A Robinson, Qingli Ma, Jane P Staveley, Walter J Smolenski
17α-Trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains trenbolone acetate (TBA) and estradiol benzoate (EB). As part of the environmental assessment of the use of Synovex(®) ONE, data were generated to characterize the fate of 17α-trenbolone, and its metabolite, trendione, in the environment. Predictions of the fate and environmental concentrations of these hormones after being land-applied require accurate estimates of the sorption of these compounds in soils...
December 13, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27937337/a-jaundiced-bodybuilder-cholestatic-hepatitis-as-side-effect-of-injectable-anabolic-androgenic-steroids
#9
Marije N Boks, Anton T Tiebosch, Laurens A van der Waaij
The use of anabolic steroids is prevalent in recreational athletes. This case report describes a young amateur bodybuilder who was referred to our outpatient clinic with jaundice and loss of appetite due to cholestatic hepatitis. Additional tests including a liver biopsy made it likely that the hepatitis was caused by the injectable anabolic steroid trenbolone enanthate. Cholestatic hepatitis may not be limited to the use of oral anabolic-androgenic steroids, as is widely assumed. Therefore, and because of other side effects, the recreational use of all forms of anabolic steroids should be discouraged...
December 12, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27769009/role-of-g-protein-coupled-estrogen-receptor-1-in-estradiol-17%C3%AE-induced-alterations-in-protein-synthesis-and-protein-degradation-rates-in-fused-bovine-satellite-cell-cultures
#10
E Kamanga-Sollo, K J Thornton, M E White, W R Dayton
In feedlot steers, estradiol-17β (E2) and combined E2 and trenbolone acetate (a testosterone analog) implants enhance rate and efficiency of muscle growth; and, consequently, these compounds are widely used as growth promoters in several countries. Treatment with E2 stimulates protein synthesis rate and suppresses protein degradation rate in fused bovine satellite cell (BSC) cultures; however, the mechanisms involved in these effects are not known with certainty. Although the genomic effects of E2 mediated through the classical estrogen receptors have been characterized, recent studies indicate that binding of E2 to the G protein-coupled estrogen receptor (GPER)-1 mediates nongenomic effects of E2 on cellular function...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27757350/body-builder-s-nightmare-black-market-steroid-injection-gone-wrong-a-case-report
#11
Or Friedman, Ehud Arad, Oded Ben Amotz
In the pursuit of success in sports, some athletes are not deterred by health risks associated with the (mis)use of black market preparations of dubious origin as performance-enhancing agents. Several studies published in the recent years demonstrated that anabolic-androgenic steroids, but also stimulants and growth hormones, are misused by numerous recreational athletes from all over the world. Trenbolone is an anabolic steroid routinely used in the finishing phase of beef production to improve animal performance and feed efficiency...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27575595/optimisation-and-validation-of-a-new-analytical-method-for-the-determination-of-four-natural-and-synthetic-hormones-using-lc-esi-ms-ms
#12
Emad Attalah, Yasmin S Nasr, Hassan A El-Gammal, F A Nour El-Dien
A rapid liquid chromatographic-tandem mass spectrometric method was developed for the simultaneous determination of four natural and synthetic hormone residues (progesterone, testosterone, trenbolone acetate and zeranol) in animal tissue samples. Sample preparation was optimised to minimise time and solvent consumption. Meat samples were mechanically homogenised and digested in a procedure that gave similar recoveries to those enzymatically hydrolysed by Helix pomatia. Efficient extraction was achieved using acidified acetonitrile (1% acetic acid)...
October 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27498382/impact-of-sediment-particle-size-on-biotransformation-of-17%C3%AE-estradiol-and-17%C3%AE-trenbolone
#13
Yun Zhang, Jodi L Sangster, Lukasz Gauza, Shannon L Bartelt-Hunt
Soil/sediment particle size has been reported to influence the sorption and bioavailability of steroid hormones in the environment. However, the impact of particle size on biotransformation has not been well elucidated. The present study investigated the dissipation of 17β-estradiol and 17β-trenbolone and the formation and degradation of the subsequent transformation products in different size fractions of a sandy and a silt loam sediment. The results showed that the decay of 17β-estradiol and 17β-trenbolone associated with fine particles followed a biphasic pattern with more rapid decay in the initial phase followed by a second phase with slower decay of the residues compared to their decay rates in the sand fraction...
August 4, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27475653/wastewater-treatment-plant-effluent-alters-pituitary-gland-gonadotropin-mrna-levels-in-juvenile-coho-salmon-oncorhynchus-kisutch
#14
Louisa B Harding, Irvin R Schultz, Denis A M da Silva, Gina M Ylitalo, Dave Ragsdale, Stephanie I Harris, Stephanie Bailey, Barry V Pepich, Penny Swanson
It is well known that endocrine disrupting compounds (EDCs) present in wastewater treatment plant (WWTP) effluents interfere with reproduction in fish, including altered gonad development and induction of vitellogenin (Vtg), a female-specific egg yolk protein precursor produced in the liver. As a result, studies have focused on the effects of EDC exposure on the gonad and liver. However, impacts of environmental EDC exposure at higher levels of the hypothalamic-pituitary-gonad axis are less well understood...
September 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27461040/optimizing-the-design-of-a-reproduction-toxicity-test-with-the-pond-snail-lymnaea-stagnalis
#15
Sandrine Charles, Virginie Ducrot, Didier Azam, Rachel Benstead, Denise Brettschneider, Karel De Schamphelaere, Sandra Filipe Goncalves, John W Green, Henrik Holbech, Thomas H Hutchinson, Daniel Faber, Filipe Laranjeiro, Peter Matthiessen, Leif Norrgren, Jörg Oehlmann, Evelyn Reategui-Zirena, Anne Seeland-Fremer, Matthias Teigeler, Jean-Pierre Thome, Marysia Tobor Kaplon, Lennart Weltje, Laurent Lagadic
This paper presents the results from two ring-tests addressing the feasibility, robustness and reproducibility of a reproduction toxicity test with the freshwater gastropod Lymnaea stagnalis (RENILYS strain). Sixteen laboratories (from inexperienced to expert laboratories in mollusc testing) from nine countries participated in these ring-tests. Survival and reproduction were evaluated in L. stagnalis exposed to cadmium, tributyltin, prochloraz and trenbolone according to an OECD draft Test Guideline. In total, 49 datasets were analysed to assess the practicability of the proposed experimental protocol, and to estimate the between-laboratory reproducibility of toxicity endpoint values...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27443199/a-screening-and-determinative-method-for-the-analysis-of-natural-and-synthetic-steroids-stilbenes-and-resorcyclic-acid-lactones-in-bovine-urine
#16
Christine Akre, Masahiro Mizuno
Our laboratory has four separate methods for the analysis of trenbolone, stilbenes, resorcyclic acid lactones, and estradiol in bovine urine. The method described in this paper was in response to a client request to consolidate the methods preferably into one method. A multiresidue semi-quantitative method was developed and any suspect positive samples detected by the method were subjected to the method of standard addition to accurately quantify the concentration of the positive analyte. Samples were enzymatically hydrolyzed using β-glucuronidase after which, supported liquid extraction on HM-N cartridges was performed, followed by solvent exchange into methyl tert-butyl ether (MTBE)...
May 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27312088/effects-of-the-antimicrobial-contaminant-triclocarban-and-co-exposure-with-the-androgen-17%C3%AE-trenbolone-on-reproductive-function-and-ovarian-transcriptome-of-the-fathead-minnow-pimephales-promelas
#17
Daniel L Villeneuve, Kathleen M Jensen, Jenna E Cavallin, Elizabeth J Durhan, Natàlia Garcia-Reyero, Michael D Kahl, Richard L Leino, Elizabeth A Makynen, Leah C Wehmas, Edward J Perkins, Gerald T Ankley
Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endocrine disruptor 17β-trenbolone (TRB) on fish reproductive function. Adult Pimephales promelas were continuously exposed to either 1 µg TCC/L or 5 µg TCC/L, to 0.5 µg TRB/L, or to a mixture (MIX) of 5 µg TCC/L and 0.5 µg TRB/L for 22 d, and a variety of reproductive and endocrine-related endpoints were examined...
January 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27302316/reproductive-effects-on-freshwater-fish-exposed-to-17%C3%AE-trenbolone-and-17%C3%AE-estradiol
#18
Joseph A Robinson, Jane P Staveley, Lisa Constantine
17α-Trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains trenbolone acetate (TBA) and estradiol benzoate (EB). As part of the environmental assessment of the use of Synovex(®) ONE, data were generated to characterize the effects of 17α-trenbolone and 17α-estradiol on the reproduction of freshwater fish. These substances are known endocrine disruptors, so the purpose of testing was not to clarify these properties but to identify concentrations representing population-relevant effects for use in risk characterization...
June 15, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27285910/active-g-protein-coupled-receptors-gpcr-matrix-metalloproteinases-2-9-mmp2-9-heparin-binding-epidermal-growth-factor-hbegf-epidermal-growth-factor-receptor-egfr-erbb2-and-insulin-like-growth-factor-1-receptor-igf-1r-are-necessary-for-trenbolone-acetate-induced
#19
K J Thornton, E Kamanga-Sollo, M E White, W R Dayton
Trenbolone acetate (TBA), a testosterone analog, increases protein synthesis and decreases protein degradation in fused bovine satellite cell (BSC) cultures. However, the mechanism through which TBA alters these processes remains unknown. Recent studies indicate that androgens improve rate and extent of muscle growth through a nongenomic mechanism involving G protein-coupled receptors (GPCR), matrix metalloproteinases (MMP), heparin-binding epidermal growth factor (hbEGF), the epidermal growth factor receptor (EGFR), erbB2, and the insulin-like growth factor-1 receptor (IGF-1R)...
June 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27246614/testosterone-and-trenbolone-enanthate-increase-mature-myostatin-protein-expression-despite-increasing-skeletal-muscle-hypertrophy-and-satellite-cell-number-in-rodent-muscle
#20
V J Dalbo, M D Roberts, C B Mobley, C Ballmann, W C Kephart, C D Fox, V A Santucci, C F Conover, L A Beggs, A Balaez, F J Hoerr, J F Yarrow, S E Borst, D T Beck
The androgen-induced alterations in adult rodent skeletal muscle fibre cross-sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10-month-old Fisher 344 rats (n = 41) assigned to Sham surgery, orchiectomy (ORX), ORX + testosterone (TEST; 7.0 mg week(-1) ) or ORX + trenbolone (TREN; 1.0 mg week(-1) ). After 29 days, animals were euthanised and the levator ani/bulbocavernosus (LABC) muscle complex was harvested for analyses. LABC muscle fCSA was 102% and 94% higher in ORX + TEST and ORX + TREN compared to ORX (p < ...
June 1, 2016: Andrologia
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