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https://www.readbyqxmd.com/read/29421751/veterinary-drug-17%C3%AE-trenbolone-promotes-the-proliferation-of-human-prostate-cancer-cell-line-through-the-akt-ar-signaling-pathway
#1
Hee-Seok Lee, Da-Woon Jung, Songyi Han, Hui-Seung Kang, Jin-Hyang Suh, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
Trenbolone acetate (TBA) is a synthetic anabolic steroidal growth factor that is used for rapid muscle development in cattle. The absorbed TBA is hydrolyzed to the active form, 17β-trenbolone (17 TB; 17β-hydroxy-estra-4,9,11-trien-3-one) in meat and milk products, which can cause adverse health effects in humans. Similar to 5α-dihydrotestosterone (DHT), 17 TB was reported to exhibit endocrine disrupting effects on animals and humans due to its androgenic effect via binding to the androgen receptor. The purpose of this study is to investigate the molecular mechanism of cell proliferation in prostate cancer (PCa) cells treated with 17 TB...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/28857258/summary-of-the-development-the-us-environmental-protection-agency-s-medaka-extended-one-generation-reproduction-test-meogrt-using-data-from-9-multigenerational-medaka-tests
#2
Kevin Flynn, Doug Lothenbach, Frank Whiteman, Dean Hammermeister, Leslie W Touart, Joe Swintek, Norihisa Tatarazako, Yuta Onishi, Taisen Iguchi, Rodney Johnson
In response to various legislative mandates, the US Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, formed the basis of a tiered testing strategy to determine the potential of pesticides, commercial chemicals, and environmental contaminants to disrupt the endocrine system. The first tier of tests is intended to detect the potential for endocrine disruption mediated through estrogen, androgen, or thyroid pathways, whereas the second tier is intended to further characterize the effects on these pathways and to establish a dose-response relationship for adverse effects...
August 30, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28854383/the-agricultural-contaminant-17%C3%AE-trenbolone-disrupts-male-male-competition-in-the-guppy-poecilia-reticulata
#3
Patrick Tomkins, Minna Saaristo, Michael G Bertram, Raymond B Tomkins, Mayumi Allinson, Bob B M Wong
Despite a growing literature highlighting the potential impact of human-induced environmental change on mechanisms of sexual selection, relatively little is known about the effects of chemical pollutants on male-male competition. One class of environmental pollutant likely to impact male competitive interactions is the endocrine-disrupting chemicals (EDCs), a large and heterogeneous group of chemical contaminants with the potential to influence morphology, physiology and behaviour at minute concentrations. One EDC of increasing concern is the synthetic, androgenic steroid 17β-trenbolone, which is used globally to promote growth in beef cattle...
August 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28648787/online-turbulent-flow-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry-for-high-throughput-screening-of-anabolic-steroids-in-horse-urine
#4
Hyun Du Shin, Joon Hyuk Suh, Junghyun Kim, Hyun-Deok Cho, Su Duk Lee, Kwan Seok Han, Yu Wang, Sang Beom Han
A high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine by online turbulent flow extraction coupled with liquid chromatography-tandem mass spectrometry was developed. The use of turbulent flow chromatography could simplify pretreatment of horse urine, which has complex matrices as well as high viscosity...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28549324/salinity-and-sensitivity-to-endocrine-disrupting-chemicals-a-comparison-of-reproductive-endpoints-in-small-bodied-fish-exposed-under-different-salinities
#5
REVIEW
Thijs Bosker, Giacomo Santoro, Steven D Melvin
The influence of salinity on toxicity outcomes has been demonstrated for various contaminants, but has received limited attention for endocrine disrupting chemicals (EDCs). Short-term laboratory tests using small-bodied fish are an important tool for evaluating impacts of EDCs on reproduction. Tests have been developed for both freshwater and estuarine/marine species, providing an opportunity to assess whether concentrations at which small-bodied fish respond to EDCs may be influenced by salinity. We conducted a semi-quantitative review of short-term laboratory tests with small-bodied fish exposed to EDCs, including 59 studies under freshwater conditions (7 species) and 23 studies conducted under saline conditions (5 species)...
September 2017: Chemosphere
https://www.readbyqxmd.com/read/28380538/anabolic-payout-of-terminal-implant-alters-adipogenic-gene-expression-of-the-longissimus-muscle-in-beef-steers
#6
RANDOMIZED CONTROLLED TRIAL
Z K Smith, K Y Chung, S L Parr, B J Johnson
This experiment evaluated the dose and payout pattern of trenbolone acetate (TBA) and estradiol-17β (E) on LM mRNA expression of adenosine monophosphate-activated protein kinase-ɑ (-ɑ), β, G protein-coupled receptor 41(), G protein-coupled receptor 43 (), γ, and stearoyl CoA desaturase () in finishing feedlot steers as indicators of adipogenesis and marbling development. British × Continental steers (n = 168; 14 pens/treatment; initial BW = 362 kg) were used in a randomized complete block design. Treatments included: no implant (NI), Revalor-S (REV-S; 120 mg TBA + 24 mg E), or Revalor-XS (REV-X; delayed release implant: 80 mg TBA + 16 mg E [uncoated], 120 mg TBA + 24 mg E [coated], 200 mg TBA + 40 mg E [total])...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28380530/effects-of-anabolic-implants-and-ractopamine-hcl-on-muscle-fiber-morphometrics-collagen-solubility-and-tenderness-of-beef-longissimus-lumborum-steaks
#7
S M Ebarb, K J Phelps, J S Drouillard, K R Maddock-Carlin, M A Vaughn, D D Burnett, J A Noel, C L Van Bibber-Krueger, C B Paulk, D M Grieger, J M Gonzalez
The objective of this study was to examine the effects of growth-promoting technologies (GP) and postmortem aging on longissimus lumborum muscle fiber cross-sectional area (CSA), collagen solubility, and their relationship to meat tenderness. Two groups of black-hided crossbred feedlot heifers (group 1: = 33, initial BW 430 ± 7 kg; group 2: = 32, initial BW 466 ± 7 kg) were blocked by BW and assigned to 1 of 3 treatments consisting of: no implant and no ractopamine hydrochloride (CON; = 21); implant, no ractopamine hydrochloride (IMP; = 22); implant and ractopamine hydrochloride (COMBO; = 22)...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28372163/abuse-of-anabolic-agents-in-beef-cattle-could-bile-be-a-possible-alternative-matrix
#8
Francesca Lega, Roberto Angeletti, Roberto Stella, Lorenzo Rigoni, Giancarlo Biancotto, Danilo Giusepponi, Simone Moretti, Giorgio Saluti, Roberta Galarini
European Union prohibited the use of anabolic agents in food producing animals since 1988. An efficient control of abuses is guaranteed not only by highly performing analytical methods, but also by knowledge of metabolic pathways, kinetics of elimination and tissue distribution. To obtain data concerning metabolites production and accumulation in bile, two typical growth promoting treatments are carried out in cattle. In the first study, sixteen beef cattle were implanted with trenbolone acetate and estradiol...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28236045/detection-and-quantification-of-12-anabolic-steroids-and-analogs-in-human-whole-blood-and-20-in-hair-using-lc-hrms-ms-application-to-real-cases
#9
Nicolas Fabresse, Stanislas Grassin-Delyle, Isabelle Etting, Jean-Claude Alvarez
We developed and validated a method to detect and quantify 12 anabolic steroids in blood (androstenedione, dihydrotestosterone, boldenone, epitestosterone, mesterolone, methandienone, nandrolone, stanozolol, norandrostenedione, tamoxifene, testosterone, trenbolone) and eight more in hair samples (nandrolone phenylpropionate, nandrolone decanoate, testosterone propionate, testosterone benzoate, testosterone cypionate, testosterone decanoate, testosterone phenylpropionate, testosterone undecanoate) using liquid chromatography coupled to high-resolution mass spectrometry...
July 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28168557/validation-of-the-oecd-reproduction-test-guideline-with-the-new-zealand-mudsnail-potamopyrgus-antipodarum-using-trenbolone-and-prochloraz
#10
Cornelia Geiß, Katharina Ruppert, Clare Askem, Carlos Barroso, Daniel Faber, Virginie Ducrot, Henrik Holbech, Thomas H Hutchinson, Paula Kajankari, Karin Lund Kinnberg, Laurent Lagadic, Peter Matthiessen, Steve Morris, Maurine Neiman, Olli-Pekka Penttinen, Paula Sanchez-Marin, Matthias Teigeler, Lennart Weltje, Jörg Oehlmann
The Organisation for Economic Cooperation and Development (OECD) provides several standard test methods for the environmental hazard assessment of chemicals, mainly based on primary producers, arthropods, and fish. In April 2016, two new test guidelines with two mollusc species representing different reproductive strategies were approved by OECD member countries. One test guideline describes a 28-day reproduction test with the parthenogenetic New Zealand mudsnail Potamopyrgus antipodarum. The main endpoint of the test is reproduction, reflected by the embryo number in the brood pouch per female...
April 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28127947/recommended-approaches-to-the-scientific-evaluation-of-ecotoxicological-hazards-and-risks-of-endocrine-active-substances
#11
Peter Matthiessen, Gerald T Ankley, Ronald C Biever, Poul Bjerregaard, Christopher Borgert, Kristin Brugger, Amy Blankinship, Janice Chambers, Katherine K Coady, Lisa Constantine, Zhichao Dang, Nancy D Denslow, David A Dreier, Steve Dungey, L Earl Gray, Melanie Gross, Patrick D Guiney, Markus Hecker, Henrik Holbech, Taisen Iguchi, Sarah Kadlec, Natalie K Karouna-Renier, Ioanna Katsiadaki, Yukio Kawashima, Werner Kloas, Henry Krueger, Anu Kumar, Laurent Lagadic, Annegaaike Leopold, Steven L Levine, Gerd Maack, Sue Marty, James Meador, Ellen Mihaich, Jenny Odum, Lisa Ortego, Joanne Parrott, Daniel Pickford, Mike Roberts, Christoph Schaefers, Tamar Schwarz, Keith Solomon, Tim Verslycke, Lennart Weltje, James R Wheeler, Mike Williams, Jeffrey C Wolf, Kunihiko Yamazaki
A SETAC Pellston Workshop(®) "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review...
March 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28127424/the-cost-of-seeking-an-edge-recurrent-renal-infarction-in-setting-of-recreational-use-of-anabolic-steroids
#12
Shaun Colburn, W Kurtis Childers, Alex Chacon, Alexa Swailes, Fauzan M Ahmed, Rajinder Sahi
INTRODUCTION: Anabolic-androgenic steroid (AAS) use and testosterone therapy have been well established risk factors for the creation of a pro-thrombotic state, and to precipitate formation of thromboemboli in individuals already predisposed to thrombosis. CASE REPORT: Here, we present the case of an amateur bodybuilder, with a negative thrombophilia workup, who experienced primary renal infarction while using the AAS trenbolone acetate and testosterone, as well as a subsequent renal infarction while anticoagulated with apixaban...
February 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28108667/effects-on-circulating-steroid-hormones-and-gene-expression-along-the-hypothalamus-pituitary-gonadal-axis-in-adult-japanese-quail-exposed-to-17%C3%AE-trenbolone-across-multiple-generations
#13
Natalie K Karouna-Renier, Yu Chen, Paula F P Henry, Catherine M Maddox, Daniel T Sprague
We investigated the effects of the androgenic growth promoter 17β-trenbolone (17βTB) on adult Japanese quail (Coturnix japonica) exposed across three generations. The F0 generation was exposed after sexual maturity to 0, 1, 5, 10, 20, and 40 ppm through feed. The F1 generation was exposed in ovo by maternal transfer and through feed at the same doses as their parents. The F2 generation was exposed in ovo only. Levels of plasma sex steroids, gonadal Cytochrome P450 aromatase (CYP19A1) mRNA and select brain neuroendocrine peptide mRNAs were measured...
May 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28074716/semiquantitative-immunohistochemical-detection-of-progesterone-receptors-in-male-accessory-sex-glands-as-a-screening-assay-for-anabolic-steroid-use-in-bulls
#14
Claudia Zanardello, Katia Capello, Roberto Stella, Giancarlo Biancotto, Marta Vascellari
We investigated the immunohistochemical expression of progesterone receptors (PRs) in the prostate and bulbourethral glands of thirty-two 10-14-mo-old Charolais bulls following treatment with a low dosage of estrogens. Animals were divided into 2 groups: 16 animals (group T) were treated for 71 d with a therapeutic dose of trenbolone acetate and estradiol by subcutaneous implant, 16 animals (group C) received no treatment. Urine samples were collected both at the beginning of the trial and 9 times during the study...
January 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28052490/population-relevant-endpoints-in-the-evaluation-of-endocrine-active-substances-eas-for-ecotoxicological-hazard-and-risk-assessment
#15
Mary S Marty, Amy Blankinship, Janice Chambers, Lisa Constantine, Werner Kloas, Anupama Kumar, Laurent Lagadic, James Meador, Daniel Pickford, Tamar Schwarz, Tim Verslycke
For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible link to a population-relevant adverse effect. Current ecotoxicity test methods incorporate mostly apical endpoints although some also include mechanistic endpoints, subcellular-through-organ level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population-level effects is often unclear. The case studies of endocrine-active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated from the Society of Environmental Toxicology and Chemistry (SETAC) Pellston Workshop(®) "Ecotoxicological Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine-disruptor frameworks such as the Organisation for Economic Co-operation and Development (OECD) Conceptual Framework for Testing and Assessment of Endocrine Disruptors...
March 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/27993082/stereoselective-degradation-of-estradiol-and-trenbolone-isomers-in-alluvial-sediment
#16
Yun Zhang, Daniel D Snow, Shannon L Bartelt-Hunt
Stereoisomers of estradiol (E2) or trenbolone (TB) can occur together in the environment receiving human or livestock wastes. However, the effect of their co-occurrence on persistence has not been well elucidated. A sandy and a silt loam sediment were used to establish microcosms with α- and β-isomers of E2 or TB spiked individually and together. Sediments were sampled periodically and analyzed for E2 and TB isomers and their transformation products using derivatization gas chromatography-mass spectrometry...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27958649/sorption-and-desorption-of-17%C3%AE-trenbolone-and-trendione-on-five-soils
#17
Joseph A Robinson, Qingli Ma, Jane P Staveley, Walter J Smolenski
The metabolites 17α-trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex(®) ONE, which contains trenbolone acetate and estradiol benzoate. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17α-trenbolone, and its metabolite trendione in the environment. Predictions of the fate and environmental concentrations of these hormones after land application require accurate estimates of the sorption of these compounds in soils...
March 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27937337/a-jaundiced-bodybuilder-cholestatic-hepatitis-as-side-effect-of-injectable-anabolic-androgenic-steroids
#18
Marije N Boks, Anton T Tiebosch, Laurens A van der Waaij
The use of anabolic steroids is prevalent in recreational athletes. This case report describes a young amateur bodybuilder who was referred to our outpatient clinic with jaundice and loss of appetite due to cholestatic hepatitis. Additional tests including a liver biopsy made it likely that the hepatitis was caused by the injectable anabolic steroid trenbolone enanthate. Cholestatic hepatitis may not be limited to the use of oral anabolic-androgenic steroids, as is widely assumed. Therefore, and because of other side effects, the recreational use of all forms of anabolic steroids should be discouraged...
December 12, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27769009/role-of-g-protein-coupled-estrogen-receptor-1-in-estradiol-17%C3%AE-induced-alterations-in-protein-synthesis-and-protein-degradation-rates-in-fused-bovine-satellite-cell-cultures
#19
E Kamanga-Sollo, K J Thornton, M E White, W R Dayton
In feedlot steers, estradiol-17β (E2) and combined E2 and trenbolone acetate (a testosterone analog) implants enhance rate and efficiency of muscle growth; and, consequently, these compounds are widely used as growth promoters in several countries. Treatment with E2 stimulates protein synthesis rate and suppresses protein degradation rate in fused bovine satellite cell (BSC) cultures; however, the mechanisms involved in these effects are not known with certainty. Although the genomic effects of E2 mediated through the classical estrogen receptors have been characterized, recent studies indicate that binding of E2 to the G protein-coupled estrogen receptor (GPER)-1 mediates nongenomic effects of E2 on cellular function...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27757350/body-builder-s-nightmare-black-market-steroid-injection-gone-wrong-a-case-report
#20
Or Friedman, Ehud Arad, Oded Ben Amotz
In the pursuit of success in sports, some athletes are not deterred by health risks associated with the (mis)use of black market preparations of dubious origin as performance-enhancing agents. Several studies published in the recent years demonstrated that anabolic-androgenic steroids, but also stimulants and growth hormones, are misused by numerous recreational athletes from all over the world. Trenbolone is an anabolic steroid routinely used in the finishing phase of beef production to improve animal performance and feed efficiency...
September 2016: Plastic and Reconstructive Surgery. Global Open
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