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marijuana muscle relaxant

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https://www.readbyqxmd.com/read/27899300/role-of-the-endocannabinoid-system-in-the-control-of-mouse-myometrium-contractility-during-the-menstrual-cycle
#1
Ester Pagano, Pierangelo Orlando, Stefania Finizio, Antonietta Rossi, Lorena Buono, Fabio Arturo Iannotti, Fabiana Piscitelli, Angelo A Izzo, Vincenzo Di Marzo, Francesca Borrelli
Cannabis and cannabinoids are known to affect female reproduction. However, the role of the endocannabinoid system in mouse uterine contractility in the dioestrus and oestrus phases has not been previously investigated. The present study aimed at filling this gap. Endocannabinoid (anandamide and 2-arachidonoylglycerol) levels were measured in mouse uterus at dioestrus and oestrus phases by liquid chromatography-mass spectrometry; quantitative reverse transcription-PCR measured mRNA expression of cannabinoid receptors and enzymes involved in the metabolism of endocannabinoids...
November 26, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/22961269/motor-cortex-and-corticospinal-excitability-in-humans-with-a-history-of-illicit-stimulant-use
#2
Stanley C Flavel, Jason M White, Gabrielle Todd
Illicit use of stimulant drugs such as methamphetamine, ecstasy, and cocaine is a current and growing problem throughout the world. The aim of the current study was to investigate the long-term effect of illicit stimulant use on human motor cortical and corticospinal circuitry. We hypothesized that individuals with a history of primarily methamphetamine and ecstasy use would exhibit altered corticospinal excitability and intracortical inhibition within motor cortex. The study involved 52 healthy adults (aged 26 ± 7 yr) comprising 26 abstinent stimulant users, 9 cannabis users, and 17 nondrug users...
November 2012: Journal of Applied Physiology
https://www.readbyqxmd.com/read/19116025/sickle-cell-trait-and-priapism-a-case-report-and-review-of-the-literature
#3
Brian F Birnbaum, Joseph J Pinzone
BACKGROUND: A 32 year-old African-American man presented to our institution after attempting suicide via ingestion with quetiapine. He had reported a history of several days of substance abuse with alcohol, cocaine and marijuana related to a partying binge. Following this, his partner removed him from his residence resulting in a suicide attempt. During hospitalization the patient developed priapism, a condition he had not experienced before. CASE PRESENTATION: Given this was his first time with priapism, an extensive work-up revealed the patient had previously undiagnosed sickle cell trait, which we postulate to have been a significant factor in his development of acute priapism...
2008: Cases Journal
https://www.readbyqxmd.com/read/17680796/recommendations-for-toxicological-investigation-of-drug-impaired-driving
#4
Laurel J Farrell, Sarah Kerrigan, Barry K Logan
Investigation of a suspected alcohol or drug impaired driving (DUID) case ideally contains several key elements, including a trained officer documenting observations of driving and subject behavior, and collection of a biological specimen for comprehensive toxicology testing. There is currently no common standard of practice among forensic toxicology laboratories in the United States as to which drugs should be tested for, and at what analytical cutoff. Having some uniformity of practice among laboratories would ensure that drugs most frequently associated with driving impairment were consistently evaluated, that appropriate methods were used to screen and confirm the presence of drugs, and that more accurate data were collected on the extent of drug use among drivers...
September 2007: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/12648025/pharmacokinetics-and-pharmacodynamics-of-cannabinoids
#5
REVIEW
Franjo Grotenhermen
Delta(9)-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. Cannabinoids exert many effects through activation of G-protein-coupled cannabinoid receptors in the brain and peripheral tissues...
2003: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/11467101/marijuana-in-the-management-of-amyotrophic-lateral-sclerosis
#6
REVIEW
G T Carter, B S Rosen
Marijuana has been proposed as treatment for a widening spectrum of medical conditions. Marijuana is a substance with many properties that may be applicable to the management of amyotrophic lateral sclerosis (ALS). These include analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. In addition, marijuana has now been shown to have strong antioxidative and neuroprotective effects, which may prolong neuronal cell survival. In areas where it is legal to do so, marijuana should be considered in the pharmacological management of ALS...
July 2001: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/10575282/-the-effects-of-cannabis-and-thc
#7
REVIEW
F Grotenhermen
Cannabis and THC exert manifold actions on a number of organ systems. A lethal dose of THC in humans is unknown. Above the psychotropic threshold, ingestion of cannabis causes an enhanced well-being and relaxation with an intensification of ordinary sensory experiences. The most important unwanted acute psychical effects are anxiety and panic attacks. Acute somatic effects are increased heart rate, changes of blood pressure, conjunctival injection and dry mouth. Properties that might be used therapeutically comprise analgesia, muscle relaxation, sedation, increase of mood, stimulation of appetite, antiemesis, lowering of intraoccular pressure and bronchodilation...
October 1999: Forschende Komplementärmedizin
https://www.readbyqxmd.com/read/3207120/ovine-placental-perfusion-balance-effect-of-marijuana-smoke
#8
J F Clapp, T M Keve, C Vial, M K McLaughlin
This study was designed to test the hypothesis that maternal marijuana smoking impairs placental oxygen transfer in late ovine pregnancy by disrupting perfusion balance between the maternal and fetal placental circulations. Placental hemodynamics were assessed in nine chronically prepared ewes 1 hour after exposure to smoke from either a marijuana (n = 5) or a placebo (n = 4) cigarette. When compared with placebo smoke, maternal marijuana smoke exposure resulted in a fall in both uterine and umbilical placental vascular resistance and a 30% improvement in placental perfusion balance at a cotyledonary level...
December 1988: American Journal of Obstetrics and Gynecology
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