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https://www.readbyqxmd.com/read/29660650/evidence-for-gastroprotective-anti-inflammatory-and-antioxidant-potential-of-methanolic-extract-of-cordia-dichotoma-leaves-on-indomethacin-and-stress-induced-gastric-lesions-in-wistar-rats
#1
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
April 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29616452/flavonoid-quercetin-methotrexate-combination-inhibits-inflammatory-mediators-and-matrix-metalloproteinase-expression-providing-protection-to-joints-in-collagen-induced-arthritis
#2
Nagaraja Haleagrahara, Kelly Hodgson, Socorro Miranda-Hernandez, Samuel Hughes, Anupama Bangra Kulur, Ketheesan Natkunum
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial tissues in joints, leading to progressive destruction of cartilage and joints. The disease-modifying anti-rheumatic drugs currently in use have side-effects. Thus, there is an urgent need for safe anti-inflammatory therapies for RA. This study aimed to evaluate the therapeutic effect of the flavonoid quercetin on arthritis in mice immunized with type II collagen (CII). An arthritis model was established in C57/BL6 mice by intradermal administration of chicken CII mixed with Freund's complete adjuvant...
April 3, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29611586/ultrasonicated-lespedeza-cuneata-extract-prevents-tnf-%C3%AE-induced-early-atherosclerosis-in-vitro-and-in-vivo
#3
Su Jeong Ha, Jangho Lee, Kyung-Mo Song, Young Ho Kim, Nam Hyouck Lee, Young-Eon Kim, Sung Keun Jung
This study evaluated the use of ultrasonication to extract Lespedeza cuneata as a potential nutraceutical for preventing vascular inflammation. Ultrasonicated L. cuneata extract (ULCE) was prepared using 20% ethanol and 2 h of ultrasonication at room temperature, and its effects were investigated using relevant in vitro and in vivo models. ULCE suppressed tumor necrosis factor-alpha (TNF-α)-induced adhesion capacity, vascular cell adhesion protein 1 (VCAM-1) expression, and nuclear factor kappa-B (NF-κB) activity in human umbilical vein endothelial cells (HUVECs)...
April 3, 2018: Food & Function
https://www.readbyqxmd.com/read/29567277/castanea-mollissima-shell-prevents-an-over-expression-of-inflammatory-response-and-accelerates-the-dermal-wound-healing
#4
Pei Luo, Xinjie Li, Yujie Ye, Xiang Shu, Jiaojiao Gong, Jianping Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Castanea mollissima shell has been used for wound healing and anti-inflammatory in traditional Chinese medicine. The shell is directly applied on the skin injury as fine powder or as water macerated. Chestnut shell poultice is externally used in the wound healing process and for the treatment of burn. AIM OF THE STUDY: In this context, validations of the ethnotherapeutic claims of the shell in wound healing activity was studied, besides anti-inflammatory activity was performed to understand the mechanism of wound healing potency...
March 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29530609/protective-effect-of-sesbania-grandiflora-on-acetic-acid-induced-ulcerative-colitis-in-mice-by-inhibition-of-tnf-%C3%AE-and-il-6
#5
Rohit A Gupta, Meha N Motiwala, Ujawala N Mahajan, Sapna S Sabare
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Sesbania grandiflora (Linn) belonging to the family Fabaceae is commonly known as sesbania, agathi, and katurai. The plant is accredited for alleviating a spectrum of ailments including inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, bronchitis, convulsion and anxiety. It is also used as antitumour, anthelmintic, and laxatives in Ayurveda and Siddha system of Indian traditional medicine. AIM: To reveal protective effect of Sesbania grandiflora in acetic acid induced ulcerative colitis in mice...
March 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29501673/lafoensia-pacari-a-st-hil-wound-healing-activity-and-mechanism-of-action-of-standardized-hydroethanolic-leaves-extract
#6
Lucas Olivo Martins Pereira, Wagner Vilegas, Marcelo Marucci Pereira Tangerina, Karuppusamy Arunachalam, Sikiru Olaitan Balogun, Paulo Eduardo Orlandi Matos, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL IMPORTANCE: Lafoensia pacari A. St.-Hil., (Lythraceae) is a native tree of Brazilian Cerrado and commonly known in Brazil as "mangava-brava". Its leaves are used in Brazilian folk medicine in wound healing, cutaneous mycoses, and in the treatment of gastritis and ulcers. AIM OF THE STUDY: The present study was designed to evaluate the wound healing activity and mechanism of action of the hydroethanolic extract of Lafoensia pacari A...
February 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29497376/the-flavonoid-quercetin-ameliorates-liver-inflammation-and-fibrosis-by-regulating-hepatic-macrophages-activation-and-polarization-in-mice
#7
Xi Li, Qianwen Jin, Qunyan Yao, Beili Xu, Lixin Li, Shuncai Zhang, Chuantao Tu
At present, there are no effective antifibrotic drugs for patients with chronic liver disease; hence, the development of antifibrotic therapies is urgently needed. Here, we performed an experimental and translational study to investigate the potential and underlying mechanism of quercetin treatment in liver fibrosis, mainly focusing on the impact of quercetin on macrophages activation and polarization. BALB/c mice were induced liver fibrosis by carbon tetrachloride (CCl4 ) for 8 weeks and concomitantly treated with quercetin (50 mg/kg) or vehicle by daily gavage...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29480020/protective-effects-of-quercetin-treatment-in-a-pristane-induced-mouse-model-of-lupus-nephritis
#8
Mariane Dos Santos, Priscila Tamar Poletti, Gaia Favero, Alessandra Stacchiotti, Francesca Bonomini, Carolina Caruccio Montanari, Silvia Regina Bona, Norma Possa Marroni, Rita Rezzani, Francisco Veríssimo Veronese
INTRODUCTION: Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice through histomorphological analyses. METHODS: Immunofluorescence and biochemical assays were used to evaluate the expression of markers of inflammation (interleukin-6, IL-6; tumour necrosis factor-α, TNF-α), oxidative stress (catalase, CAT; superoxide dismutase 1, SOD1; thiobarbituric acid reactive substances, TBARS), apoptosis (Bax), and fibrosis (transforming growth factor-β1, TGF-β1)...
February 26, 2018: Autoimmunity
https://www.readbyqxmd.com/read/29405788/upregulation-of-cd4-t-lymphocytes-by-isomeric-mixture-of-quercetin-3-o-rutinoside-and-quercetin-3-o-robinobioside-isolated-from-millettia-aboensis
#9
Daniel Lotanna Ajaghaku, Peter Achunike Akah, Emmanuel Emeka Ilodigwe, Sunday Odunke Nduka, Uduma Eke Osonwa, Festus Basden Chinedu Okoye
BACKGROUND: Millettia aboensis (Hook. F.) Baker (Fabaceae) is popular in ethnomedicine for its acclaimed efficacy in a number of disease conditions. This study evaluated the immunomodulatory effect of the leaf extract as a possible mechanism of its ethnomedicinal uses. METHODS: Humoral and cellular immune responses of Balb/c mice to tetanus toxoid and cyclophosphamide, respectively, were used to monitor immunomodulatory activities of the ethanol leaf extract and fractions of M...
February 6, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29393507/the-induced-rna-binding-protein-hur-targets-3-utr-region-of-il-6-mrna-and-enhances-its-stabilization-in-periodontitis
#10
Kazuhisa Ouhara, Syuichi Munenaga, Mikihito Kajiya, Katsuhiro Takeda, Shinji Matsuda, Yoko Sato, Yuta Hamamoto, Tomoyuki Iwata, Satoshi Yamasaki, Keiichi Akutagawa, Noriyoshi Mizuno, Tsuyoshi Fujita, Eiji Sugiyama, Hidemi Kurihara
RNA-binding proteins (RBPs) regulate mRNA stability by binding to the 3'-UTR region of mRNA. Human antigen-R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis, diabetes mellitus, some inflammatory diseases. Interleukin (IL)-6 is a major inflammatory cytokine regulated by HuR binding to mRNA. Periodontal disease (PD) is also an inflammatory disease caused by elevations in IL-6 following an infection by periodontopathognic bacteria. The involvement of HuR in the progression of PD was assessed using in vitro and in vivo experiment...
February 2, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29389576/hepatoprotective-effect-of-the-ethanol-extract-of-polygonum-orientale-on-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#11
Yung-Jia Chiu, Shen-Chieh Chou, Chuan-Sung Chiu, Chun-Pin Kao, Kun-Chang Wu, Chao-Jung Chen, Jen-Chieh Tsai, Wen-Huang Peng
Polygonum orientale L. (Polygonaceae) fruits have various medicinal uses, but their hepatoprotective effects have not yet been studied. This study investigated the hepatoprotective activity of the ethanolic extract of P. orientale (POE) fruits against carbon tetrachloride (CCl4)-induced acute liver injury (ALI). Mice were pretreated with POE (0.1, 0.5, and 1.0 g/kg) or silymarin (0.2 g/kg) for 5 consecutive days and administered a dose of 0.175% CCl4 (ip) on the 5th day to induce ALI. Blood and liver samples were collected to measure antioxidative activity and cytokines...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29285175/quercetin-prevents-alcohol-induced-liver-injury-through-targeting-of-pi3k-akt-nuclear-factor-%C3%AE%C2%BAb-and-stat3-signaling-pathway
#12
Minglin Zhu, Xuefeng Zhou, Jinping Zhao
Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29197723/the-flavonoid-quercetin-inhibits-titanium-dioxide-tio-2-induced-chronic-arthritis-in-mice
#13
Sergio M Borghi, Sandra S Mizokami, Felipe A Pinho-Ribeiro, Victor Fattori, Jefferson Crespigio, Juliana T Clemente-Napimoga, Marcelo H Napimoga, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Rubia Casagrande, Waldiceu A Verri
Titanium dioxide (TiO2 ) is a common component of orthopedic prosthesis. However, prosthesis wear releases TiO2 , which induces inflammation and osteolysis in peri-prosthetic tissues. Quercetin is a flavonoid widely present in human diet, which presents biological activities such as antinociceptive, anti-inflammatory and antioxidant effects. Therefore, the effect of intraperitoneal treatment with quercetin in TiO2 -induced arthritis model was evaluated. In the first set of experiments, mice received injection of TiO2 (0...
March 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29152632/a-combination-of-quercetin-and-resveratrol-reduces-obesity-in-high-fat-diet-fed-rats-by-modulation-of-gut-microbiota
#14
Le Zhao, Qi Zhang, Weini Ma, Feng Tian, Hongyi Shen, Mingmei Zhou
Resveratrol and quercetin, widely found in foods and vegetables, are plant polyphenols reported to have a wide range of biological activities. Despite their limited bioavailabilities, both resveratrol and quercetin are known to exhibit anti-inflammation and anti-obesity effects. We hypothesized that gut microbiota may be a potential target for resveratrol and quercetin to prevent the development of obesity. The aim of this research was to confirm whether a combination of quercetin and resveratrol (CQR) could restore the gut microbiota dysbiosis induced by a high-fat diet (HFD)...
December 13, 2017: Food & Function
https://www.readbyqxmd.com/read/29149703/quercetin-attenuates-collagen-induced-arthritis-by-restoration-of-th17-treg-balance-and-activation-of-heme-oxygenase-1-mediated-anti-inflammatory-effect
#15
Yan Yang, Xu Zhang, Min Xu, Xin Wu, Feipeng Zhao, Chengzhi Zhao
Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and should be gotten further insight into. QU at a dosage of 150 mg/kg was administered orally in collagen-induced arthritis rats and then the clinical symptoms were monitored. The protein levels of Th17/Treg-related cytokines were determined by ELISA, and the mRNA levels of cytokines and transcription factors associated with the Th17 and Treg phenotypes were evaluated by real-time PCR, the proportions of Th17 and Treg cells were assessed by flow cytometry...
January 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29115568/radical-scavenging-linked-anti-adipogenic-activity-of-alnus-firma-extracts
#16
Sun-Il Choi, Jong Seok Lee, Sarah Lee, Jin-Ha Lee, Hee-Sun Yang, Joohong Yeo, Jong-Yea Kim, Boo-Yong Lee, Il-Jun Kang, Ok-Hwan Lee
The purpose of the present study was to investigate the antioxidant activity and anti-adipogenic effect of extracts from Alnus firma (A. firma), which is an edible plant that grows in mountainous areas. The total phenolic, flavonoid and anthocyanin content as well as the antioxidant activity of a 70% ethanolic extract of A. firma (AFE) was assessed. Furthermore, the effects of AFE on lipid accumulation and reactive oxygen species (ROS) production during adipogenesis of 3T3-L1 cells were investigated. The results revealed that the total phenolic, flavonoid and pro-anthocyanidin content of AFE as 436...
January 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29107927/photochemoprotective-effect-of-a-fraction-of-a-partially-purified-extract-of-byrsonima-crassifolia-leaves-against-uvb-induced-oxidative-stress-in-fibroblasts-and-hairless-mice
#17
Rebeca Oliveira de Souza, Geórgia de Assis Dias Alves, Ana Luiza Scarano Aguillera, Hervé Rogez, Maria José Vieira Fonseca
Ultraviolet B (UVB) irradiation increases the risk of various skin disorders, leading to inflammation and oxidative stress and thereby increasing the risk of skin photoaging and carcinogenesis. The use of photochemoprotectors such as natural products with antioxidant and anti-inflammatory properties represents a strategy for preventing UVB-induced skin damage. We investigated the photochemoprotective effect of a fraction of a partially purified extract of Byrsonima crassifolia leaves (BCF) on fibroblasts and hairless mice exposed to UVB radiation...
January 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29056550/piperine-in-combination-with-quercetin-halt-6-ohda-induced-neurodegeneration-in-experimental-rats-biochemical-and-neurochemical-evidences
#18
Shamsher Singh, Puneet Kumar
Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) unilaterally, intranigrally once into right SNpc. Pre-treatment with QC (25 and 50mg/kg, p.o.) alone and combination of QC (25mg/kg, p.o.) with piperine (2.5mg/kg, p.o.) were given for 14days starting from 8th day of 6-OHDA infusion...
October 19, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29052001/quail-coturnix-japonica-egg-yolk-bioactive-components-attenuate-streptozotocin-induced-testicular-damage-and-oxidative-stress-in-diabetic-rats
#19
Gideon Oludare Oladipo, Chidinma Martha Nlekerem, Emmanuel Oluwafemi Ibukun, Ayodele Oluseyi Kolawole
INTRODUCTION: The testicular milieu is the machinery for the metabolism of testosterone in the male reproductive system. PURPOSE: The dysfunction of this highly regenerating system is inevitable in the condition of glucose imbalance as a result of insulin machinery impairment. Therefore, it is imperative to recommend dietary intervention for attenuating the testicular dysfunction and oxidative stress resulting from STZ-induction of diabetes. METHODS: STZ-induced diabetes (65 mg/kg, ip) was treated with QEYEM (50, 100 and 200 mg/kg/day) and quercetin (50 mg/kg/day) for 7weeks...
October 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#20
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
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