keyword
MENU ▼
Read by QxMD icon Read
search

quercetin, il-6

keyword
https://www.readbyqxmd.com/read/29903008/immunomodulatory-properties-of-quercetin-3-o-%C3%AE-l-rhamnopyranoside-from-rapanea-melanophloeos-against-influenza-a-virus
#1
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O Aro, Jacobus N Eloff, Lyndy J McGaw, Folorunso O Fasina
BACKGROUND: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. The South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez of the family Myrsinaceae was selected owing to its traditional use for the treatment of several diseases such as respiratory ailments and also previous preliminary studies of anti-influenza activity of its methanolic extract...
June 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29777902/chemical-characterization-and-cerebroprotective-effect-of-methanolic-root-extract-of-colebrookea-oppositifolia-in-rats
#2
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29775228/uroprotective-mechanism-of-quercetin-against-cyclophosphamide-induced-urotoxicity-effect-on-oxidative-stress-and-inflammatory-markers
#3
Iman O Sherif
The urotoxicity is a common complication associated with patients receiving cyclophosphamide (CYP). This study was designed to investigate the uroprotective mechanism of quercetin (Quer) flavonoid against CYP induced urotoxicity via determination of oxidative stress markers as well as inflammatory mediators in bladder tissue. Forty male Wistar rats were divided into four groups; Normal group: received saline for 10 days. Quer control group: received quercetin 50 mg/kg/day for 10 days. CYP group: received saline for 10 days and injected with a single dose of 150 mg/kg CYP intraperitoneal (i...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29771441/combinatory-effect-of-mesenchymal-stromal-cells-transplantation-and-quercetin-after-spinal-cord-injury-in-rat
#4
X Wang, Y-Y Wang, L-L Zhang, G-T Li, H-T Zhang
OBJECTIVE: To investigate the synergistic effects of quercetin (Qu) administration and transplantation of human umbilical cord mesenchymal stromal cells (HUMSCs) following spinal cord injury (SCI). MATERIALS AND METHODS: HUMSCs were isolated, cultured and certificated via flow cytometry. Sixty Sprague-Dawley (SD) female rats were used and SCI models were made. All rats were divided into five experimental groups: culture medium treated group (n=28); HUSMCs + quercetin-treated group (n = 28); HUMSCs treated group (n=28); quercetin-treated group (n = 28); sham group (n = 20)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29720826/the-effects-of-hesperidin-and-quercetin-on-serum-tumor-necrosis-factor-alpha-and-interleukin-6-levels-in-streptozotocin-induced-diabetes-model
#5
Eda Dokumacioglu, Hatice Iskender, Tugba Mazlum Sen, Imran Ince, Ali Dokumacioglu, Yalcin Kanbay, Elif Erbas, Sinan Saral
Background: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of carbohydrate, fat and protein metabolism, and it is characterized by hyperglycemia and leads to various complications. Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin , which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29692723/biological-activities-of-heteropyxis-natalensis-against-micro-organisms-involved-in-oral-infections
#6
Cynthia J Henley-Smith, Francien S Botha, Ahmed A Hussein, Mpumelelo Nkomo, Debra Meyer, Namrita Lall
The use of complementary and alternative medicine from plants in South Africa, as in the rest of the world, continues to increase. Heteropyxis natalensis , known as the Lavender tree, is indigenous to South Africa and is traditionally used for oral care. The ethanolic extract, of the leaves and twigs, of H. natalensis was investigated for antimicrobial activity against selected oral microorganisms. Actinomyces israelii was found to be the most sensitive oral microorganism to the extract, with a minimum inhibitory concentration (MIC) of 0...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29660650/evidence-for-gastroprotective-anti-inflammatory-and-antioxidant-potential-of-methanolic-extract-of-cordia-dichotoma-leaves-on-indomethacin-and-stress-induced-gastric-lesions-in-wistar-rats
#7
Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Meghanath Shete, Sravani Karri, Gaurav Gupta
The Cordia dichotoma (CD) is having anticancer and other pharmacological effects as it contains mainly flavonoids. The present study was aimed to demonstrate the gastroprotective effect of methanolic extract of CD leaves (MECD) obtained using Soxhlet extractor. In this study the qualitative phytochemical analysis of MECD revealed the presence of bioflavonoids and determination of quercetin was confirmed by HPLC analysis. The MECD was administered orally at doses 50 mg/kg, 100 mg/kg and 200 mg/kg against indomethacin induced gastric ulceration and stress-induced gastric ulceration in Wistar rats...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29616452/flavonoid-quercetin-methotrexate-combination-inhibits-inflammatory-mediators-and-matrix-metalloproteinase-expression-providing-protection-to-joints-in-collagen-induced-arthritis
#8
Nagaraja Haleagrahara, Kelly Hodgson, Socorro Miranda-Hernandez, Samuel Hughes, Anupama Bangra Kulur, Natkunam Ketheesan
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial tissues in joints, leading to progressive destruction of cartilage and joints. The disease-modifying anti-rheumatic drugs currently in use have side-effects. Thus, there is an urgent need for safe anti-inflammatory therapies for RA. This study aimed to evaluate the therapeutic effect of the flavonoid quercetin on arthritis in mice immunized with type II collagen (CII). An arthritis model was established in C57/BL6 mice by intradermal administration of chicken CII mixed with Freund's complete adjuvant...
April 3, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29611586/ultrasonicated-lespedeza-cuneata-extract-prevents-tnf-%C3%AE-induced-early-atherosclerosis-in-vitro-and-in-vivo
#9
Su Jeong Ha, Jangho Lee, Kyung-Mo Song, Young Ho Kim, Nam Hyouck Lee, Young-Eon Kim, Sung Keun Jung
This study evaluated the use of ultrasonication to extract Lespedeza cuneata as a potential nutraceutical for preventing vascular inflammation. Ultrasonicated L. cuneata extract (ULCE) was prepared using 20% ethanol and 2 h of ultrasonication at room temperature, and its effects were investigated using relevant in vitro and in vivo models. ULCE suppressed tumor necrosis factor-alpha (TNF-α)-induced adhesion capacity, vascular cell adhesion protein 1 (VCAM-1) expression, and nuclear factor kappa-B (NF-κB) activity in human umbilical vein endothelial cells (HUVECs)...
April 25, 2018: Food & Function
https://www.readbyqxmd.com/read/29567277/castanea-mollissima-shell-prevents-an-over-expression-of-inflammatory-response-and-accelerates-the-dermal-wound-healing
#10
Pei Luo, Xinjie Li, Yujie Ye, Xiang Shu, Jiaojiao Gong, Jianping Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Castanea mollissima shell (CMS) has been used for wound healing in China as traditional medicine. The shell is directly applied on the wounded skin as fine powder or as water maceration. AIM OF THE STUDY: To investigate the wound healing activity of CMS and the potential mechanism of anti-inflammatory activity. MATERIALS AND METHODS: The effects of ethanol extract of CMS (ECMS) on nitricoxide (NO), tumor necrosis factor (TNF)-α and interleukin (IL)- 6 productions in lipopolysaccharide (LPS)-treated RAW 264...
June 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29530609/protective-effect-of-sesbania-grandiflora-on-acetic-acid-induced-ulcerative-colitis-in-mice-by-inhibition-of-tnf-%C3%AE-and-il-6
#11
Rohit A Gupta, Meha N Motiwala, Ujawala N Mahajan, Sapna G Sabre
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Sesbania grandiflora (Linn) belonging to the family Fabaceae is commonly known as sesbania, agathi, and katurai. The plant is accredited for alleviating a spectrum of ailments including inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, bronchitis, convulsion and anxiety. It is also used as antitumour, anthelmintic, and laxatives in Ayurveda and Siddha system of Indian traditional medicine. AIM: To reveal protective effect of Sesbania grandiflora in acetic acid induced ulcerative colitis in mice...
March 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29501673/lafoensia-pacari-a-st-hil-wound-healing-activity-and-mechanism-of-action-of-standardized-hydroethanolic-leaves-extract
#12
Lucas Olivo Martins Pereira, Wagner Vilegas, Marcelo Marucci Pereira Tangerina, Karuppusamy Arunachalam, Sikiru Olaitan Balogun, Paulo Eduardo Orlandi-Mattos, Edson Moleta Colodel, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL IMPORTANCE: Lafoensia pacari A. St.-Hil., (Lythraceae) is a native tree of Brazilian Cerrado and commonly known in Brazil as "mangava-brava". Its leaves are used in Brazilian folk medicine in wound healing, cutaneous mycoses, and in the treatment of gastritis and ulcers. AIM OF THE STUDY: The present study was designed to evaluate the wound healing activity and mechanism of action of the hydroethanolic extract of Lafoensia pacari A...
March 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29497376/the-flavonoid-quercetin-ameliorates-liver-inflammation-and-fibrosis-by-regulating-hepatic-macrophages-activation-and-polarization-in-mice
#13
Xi Li, Qianwen Jin, Qunyan Yao, Beili Xu, Lixin Li, Shuncai Zhang, Chuantao Tu
At present, there are no effective antifibrotic drugs for patients with chronic liver disease; hence, the development of antifibrotic therapies is urgently needed. Here, we performed an experimental and translational study to investigate the potential and underlying mechanism of quercetin treatment in liver fibrosis, mainly focusing on the impact of quercetin on macrophages activation and polarization. BALB/c mice were induced liver fibrosis by carbon tetrachloride (CCl4 ) for 8 weeks and concomitantly treated with quercetin (50 mg/kg) or vehicle by daily gavage...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29480020/protective-effects-of-quercetin-treatment-in-a-pristane-induced-mouse-model-of-lupus-nephritis
#14
Mariane Dos Santos, Priscila Tamar Poletti, Gaia Favero, Alessandra Stacchiotti, Francesca Bonomini, Carolina Caruccio Montanari, Silvia Regina Bona, Norma Possa Marroni, Rita Rezzani, Francisco Veríssimo Veronese
INTRODUCTION: Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice through histomorphological analyses. METHODS: Immunofluorescence and biochemical assays were used to evaluate the expression of markers of inflammation (interleukin-6, IL-6; tumour necrosis factor-α, TNF-α), oxidative stress (catalase, CAT; superoxide dismutase 1, SOD1; thiobarbituric acid reactive substances, TBARS), apoptosis (Bax), and fibrosis (transforming growth factor-β1, TGF-β1)...
March 2018: Autoimmunity
https://www.readbyqxmd.com/read/29405788/upregulation-of-cd-4-t-lymphocytes-by-isomeric-mixture-of-quercetin-3-o-rutinoside-and-quercetin-3-o-robinobioside-isolated-from-millettia-aboensis
#15
Daniel Lotanna Ajaghaku, Peter Achunike Akah, Emmanuel Emeka Ilodigwe, Sunday Odunke Nduka, Uduma Eke Osonwa, Festus Basden Chinedu Okoye
BACKGROUND: Millettia aboensis (Hook. F.) Baker (Fabaceae) is popular in ethnomedicine for its acclaimed efficacy in a number of disease conditions. This study evaluated the immunomodulatory effect of the leaf extract as a possible mechanism of its ethnomedicinal uses. METHODS: Humoral and cellular immune responses of Balb/c mice to tetanus toxoid and cyclophosphamide, respectively, were used to monitor immunomodulatory activities of the ethanol leaf extract and fractions of M...
May 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29393507/the-induced-rna-binding-protein-hur-targets-3-utr-region-of-il-6-mrna-and-enhances-its-stabilization-in-periodontitis
#16
K Ouhara, S Munenaga, M Kajiya, K Takeda, S Matsuda, Y Sato, Y Hamamoto, T Iwata, S Yamasaki, K Akutagawa, N Mizuno, T Fujita, E Sugiyama, H Kurihara
RNA-binding proteins (RBPs) regulate mRNA stability by binding to the 3'-untranslated region (UTR) region of mRNA. Human antigen-R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis, diabetes mellitus and some inflammatory diseases. Interleukin (IL)-6 is a major inflammatory cytokine regulated by HuR binding to mRNA. Periodontal disease (PD) is also an inflammatory disease caused by elevations in IL-6 following an infection by periodontopathogenic bacteria. The involvement of HuR in the progression of PD was assessed using in-vitro and in-vivo experiments...
February 2, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29389576/hepatoprotective-effect-of-the-ethanol-extract-of-polygonum-orientale-on-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#17
Yung-Jia Chiu, Shen-Chieh Chou, Chuan-Sung Chiu, Chun-Pin Kao, Kun-Chang Wu, Chao-Jung Chen, Jen-Chieh Tsai, Wen-Huang Peng
Polygonum orientale L. (Polygonaceae) fruits have various medicinal uses, but their hepatoprotective effects have not yet been studied. This study investigated the hepatoprotective activity of the ethanolic extract of P. orientale (POE) fruits against carbon tetrachloride (CCl4 )-induced acute liver injury (ALI). Mice were pretreated with POE (0.1, 0.5, and 1.0 g/kg) or silymarin (0.2 g/kg) for 5 consecutive days and administered a dose of 0.175% CCl4 (ip) on the 5th day to induce ALI. Blood and liver samples were collected to measure antioxidative activity and cytokines...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29285175/quercetin-prevents-alcohol-induced-liver-injury-through-targeting-of-pi3k-akt-nuclear-factor-%C3%AE%C2%BAb-and-stat3-signaling-pathway
#18
Minglin Zhu, Xuefeng Zhou, Jinping Zhao
Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29197723/the-flavonoid-quercetin-inhibits-titanium-dioxide-tio-2-induced-chronic-arthritis-in-mice
#19
Sergio M Borghi, Sandra S Mizokami, Felipe A Pinho-Ribeiro, Victor Fattori, Jefferson Crespigio, Juliana T Clemente-Napimoga, Marcelo H Napimoga, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Rubia Casagrande, Waldiceu A Verri
Titanium dioxide (TiO2 ) is a common component of orthopedic prosthesis. However, prosthesis wear releases TiO2 , which induces inflammation and osteolysis in peri-prosthetic tissues. Quercetin is a flavonoid widely present in human diet, which presents biological activities such as antinociceptive, anti-inflammatory and antioxidant effects. Therefore, the effect of intraperitoneal treatment with quercetin in TiO2 -induced arthritis model was evaluated. In the first set of experiments, mice received injection of TiO2 (0...
March 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29152632/a-combination-of-quercetin-and-resveratrol-reduces-obesity-in-high-fat-diet-fed-rats-by-modulation-of-gut-microbiota
#20
Le Zhao, Qi Zhang, Weini Ma, Feng Tian, Hongyi Shen, Mingmei Zhou
Resveratrol and quercetin, widely found in foods and vegetables, are plant polyphenols reported to have a wide range of biological activities. Despite their limited bioavailabilities, both resveratrol and quercetin are known to exhibit anti-inflammation and anti-obesity effects. We hypothesized that gut microbiota may be a potential target for resveratrol and quercetin to prevent the development of obesity. The aim of this research was to confirm whether a combination of quercetin and resveratrol (CQR) could restore the gut microbiota dysbiosis induced by a high-fat diet (HFD)...
December 13, 2017: Food & Function
keyword
keyword
119765
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"