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JOURNAL ARTICLE
Jason J Luke, Diwakar Davar, Robert H Andtbacka, Nina Bhardwaj, Joshua D Brody, Jason Chesney, Robert Coffin, Thierry de Baere, Tanja D de Gruijl, Matthew Fury, Gregory Goldmacher, Kevin J Harrington, Howard Kaufman, Ciara M Kelly, Anuradha D Khilnani, Ke Liu, Sherene Loi, Georgina V Long, Ignacio Melero, Mark Middleton, Bart Neyns, David J Pinato, Rahul A Sheth, Stephen B Solomon, Philippe Szapary, Aurelien Marabelle
BACKGROUND: Intratumorally delivered immunotherapies have the potential to favorably alter the local tumor microenvironment and may stimulate systemic host immunity, offering an alternative or adjunct to other local and systemic treatments. Despite their potential, these therapies have had limited success in late-phase trials for advanced cancer resulting in few formal approvals. The Society for Immunotherapy of Cancer (SITC) convened a panel of experts to determine how to design clinical trials with the greatest chance of demonstrating the benefits of intratumoral immunotherapy for patients with cancers across all stages of pathogenesis...
April 18, 2024: Journal for Immunotherapy of Cancer
#22
JOURNAL ARTICLE
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M Mendes
The molecular recognition of saccharides by synthetic hosts has become an appealing but elusive task in the last decades. Herein, we combine Dynamic Combinatorial Chemistry (DCC) for the rapid self-assembly and screening of virtual libraries of receptors, with the use of ITC and NMR to validate the hits and molecular modelling to understand the binding mechanisms. We discovered a minimalistic receptor, 1F ( N -benzyl-L-phenylalanine), with considerable affinity for fructose ( K a = 1762 M-1 ) and remarkable selectivity (>50-fold) over other common monosaccharides...
April 19, 2024: Organic & Biomolecular Chemistry
#23
Jose Alejandro Posso-Nuñez, Astrid Carolina Álvarez-Ortega, Diego Fernando Bautista-Rincón, Carlos Alejandro García-González, Indira Fabiana Cujiño-Álvarez, Álvaro Ignacio Sánchez-Ortiz, Mauricio Velásquez-Galvis
A 47-year-old male patient was referred to a level 1 trauma center with refractory acute respiratory distress syndrome, bilateral lung contusions, and flail chest after initial management for injuries sustained 5 days prior from an 8-m fall from a tower crane. Surgical stabilization of the rib fractures was achieved under extracorporeal membrane oxygenation support, with successful decannulation 4 days after surgery. The patient was discharged after 42 days and following multidisciplinary interventions...
June 2024: Trauma Case Reports
#24
REVIEW
Ignacio Negrón-Oyarzo, Tatiana Dib, Lorena Chacana-Véliz, Nélida López-Quilodrán, Jocelyn Urrutia-Piñones
Cognitive control of behavior is crucial for well-being, as allows subject to adapt to changing environments in a goal-directed way. Changes in cognitive control of behavior is observed during cognitive decline in elderly and in pathological mental conditions. Therefore, the recovery of cognitive control may provide a reliable preventive and therapeutic strategy. However, its neural basis is not completely understood. Cognitive control is supported by the prefrontal cortex, structure that integrates relevant information for the appropriate organization of behavior...
2024: Frontiers in Neural Circuits
#25
JOURNAL ARTICLE
Sara Monzón, Sarai Varona, Anabel Negredo, Santiago Vidal-Freire, Juan Angel Patiño-Galindo, Natalia Ferressini-Gerpe, Angel Zaballos, Eva Orviz, Oskar Ayerdi, Ana Muñoz-Gómez, Alberto Delgado-Iribarren, Vicente Estrada, Cristina García, Francisca Molero, Patricia Sánchez-Mora, Montserrat Torres, Ana Vázquez, Juan-Carlos Galán, Ignacio Torres, Manuel Causse Del Río, Laura Merino-Diaz, Marcos López, Alicia Galar, Laura Cardeñoso, Almudena Gutiérrez, Cristina Loras, Isabel Escribano, Marta E Alvarez-Argüelles, Leticia Del Río, María Simón, María Angeles Meléndez, Juan Camacho, Laura Herrero, Pilar Jiménez, María Luisa Navarro-Rico, Isabel Jado, Elaina Giannetti, Jens H Kuhn, Mariano Sanchez-Lockhart, Nicholas Di Paola, Jeffrey R Kugelman, Susana Guerra, Adolfo García-Sastre, Isabel Cuesta, Maripaz P Sánchez-Seco, Gustavo Palacios
The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or subclade IIa MPXV, possibly caused by genomic changes in subclade IIb MPXV. Key genomic changes could occur in the genome's low-complexity regions (LCRs), which are challenging to sequence and are often dismissed as uninformative. Here, using a combination of highly sensitive techniques, we determine a high-quality MPXV genome sequence of a representative of the current epidemic with LCRs resolved at unprecedented accuracy...
April 18, 2024: Nature Communications
#26
JOURNAL ARTICLE
Antonio Arnaiz-Villena, Ignacio Juarez, Christian Vaquero-Yuste, Tomas Lledo, Jose Manuel Martin-Villa, Fabio Suarez-Trujillo
HLA studies in Crete show that this population is related to North Africans and also Iberians. This may be a reflection of a common prehistoric first Europeans relationships with North Africans and drying Saharan emigration after 10,000 years BC; it may be specifically represented by a primitive and early cult to the bull in both Cretan (Minoan) and Iberian populations. In the present study, unrelated Cretans representing different Island parts have been studied for class II HLA-DRB1 and -DQB1 alleles...
April 17, 2024: Human Immunology
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JOURNAL ARTICLE
Gilnei B da Silva, Daiane Manica, Alana P da Silva, Eduarda Valcarenghi, Sabine R Donassolo, Greicy C Kosvoski, Maiqueli E D Mingoti, Jullye Gavioli, Joana V Cassol, Marceli C Hanauer, Mariélly B Hellmann, Filomena Marafon, Amanda G Bertollo, Jesiel de Medeiros, Arthur D Cortez, Gislaine Z Réus, Gabriela G de Oliveira, Zuleide M Ignácio, Margarete D Bagatini
We evaluated glycemia and triglyceride, hepatic, muscular, and renal damage markers, redox profile, and leptin and ghrelin hormone levels of COVID-19 patients. We also realized statistical analysis to verify the potential of biomarkers to predict poor prognosis and the correlation between them in severe cases. We assessed glycemia and the levels of triglycerides, hepatic, muscular, and renal markers in automatized biochemical analyzer. The leptin and ghrelin hormones were assessed by the ELISA assay. Severe cases presented high glycemia and triglyceride levels...
April 16, 2024: American Journal of the Medical Sciences
#28
JOURNAL ARTICLE
Francesco Massari, Matteo Santoni, Hideki Takeshita, Yohei Okada, Jose Carlos Tapia, Umberto Basso, Marco Maruzzo, Sarah Scagliarini, Thomas Büttner, Giuseppe Fornarini, Zin W Myint, Luca Galli, Vinicius Carrera Souza, Renate Pichler, Ugo De Giorgi, Nathalia Gandur, Elaine T Lam, Danielle Gilbert, Lazar Popovic, Enrique Grande, Giulia Mammone, Rossana Berardi, Simon J Crabb, Robert Kemp, Javier Molina-Cerrillo, Marcelo Freitas, Murilo Luz, Roberto Iacovelli, Fabio Calabrò, Deniz Tural, Francesco Atzori, Zsófia Küronya, Rita Chiari, Saul Campos, Orazio Caffo, André P Fay, Jakub Kucharz, Paolo Andrea Zucali, José Augusto Rinck, Annalisa Zeppellini, Diogo Assed Bastos, Gaetano Aurilio, Augusto Mota, Karine Trindade, Cinzia Ortega, Juan Pablo Sade, Mimma Rizzo, Ondřej Fiala, Nuno Vau, Patrizia Giannatempo, Allan Barillas, Fernando Sabino M Monteiro, Breno Dauster, Alessia Mennitto, Lucas Nogueira, Roni de Carvalho Fernandes, Emmanuel Seront, Luís Garcia Aceituno, Francesco Grillone, Hernan Javier Cutuli, Mauricio Fernandez, Maria Bassanelli, Ray Manneh Kopp, Giandomenico Roviello, Halima Abahssain, Giuseppe Procopio, Michele Milella, Jindrich Kopecky, Angelo Martignetti, Carlo Messina, Manuel Caitano, Eva Inman, Ravindran Kanesvaran, Daniel Herchhorn, Daniele Santini, Aristotelis Bamias, Renato Bisonni, Alessandra Mosca, Franco Morelli, Fernando Maluf, Andrey Soares, Fernando Nunes, Alvaro Pinto, Anca Zgura, Lorena Incorvaia, Jawaher Ansari, Ignacio Ortego Zabalza, Johannes Landmesser, Alessandro Rizzo, Veronica Mollica, Andrea Marchetti, Matteo Rosellini, Giulia Sorgentoni, Nicola Battelli, Sebastiano Buti, Camillo Porta, Joaquim Bellmunt
BACKGROUND: Immune checkpoint inhibitors have changed previous treatment paradigm of advanced urothelial carcinoma (UC). The ARON-2 study (NCT05290038) aimed to assess the real-world effectiveness of pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. PATIENTS AND METHODS: Medical records of patients with documented metastatic UC treated by pembrolizumab as second-line therapy were retrospectively collected from 88 institutions in 23 countries...
April 18, 2024: Cancer Immunology, Immunotherapy: CII
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JOURNAL ARTICLE
Victoria Rotaru, Pedro Vidal-Fuentes, Xavier Alcobe, Tariq Jawhari, Alex López-García, Alejandro Pérez-Rodríguez, Ignacio Becerril-Romero, Victor Izquierdo-Roca, Maxim Guc
Recently, the interest for the family of low dimensional materials has increased significantly due to the anisotropic nature of their fundamental properties. Among them, antimony sulfide (Sb2 S3 ) is considered a suitable material for various solid-state devices. Although the main advantages and physicochemical properties of Sb2 S3 are known, some doubtful information remains in literature and methodologies to easily assess its critical properties are missing. In this study, an advanced characterization of several types of Sb2 S3 samples, involving the Rietveld refinement of structural properties, and Raman spectroscopy analysis, completed with lattice dynamics investigations reveal important insights into the structural and vibrational characteristics of the material...
April 19, 2024: IScience
#30
JOURNAL ARTICLE
Ignacio A Perez, Dana Ben Porath, Cristian E La Rocca, Lidia A Braunstein, Shlomo Havlin
While network abrupt breakdowns due to overloads and cascading failures have been studied extensively, the critical exponents and the universality class of such phase transitions have not been discussed. Here, we study breakdowns triggered by failures of links and overloads in networks with a spatial characteristic link length ζ. Our results indicate that this abrupt transition has features and critical exponents similar to those of interdependent networks, suggesting that both systems are in the same universality class...
March 2024: Physical Review. E
#31
JOURNAL ARTICLE
Farzin Kamari, Esben Eller, Mathias Emil Bøgebjerg, Ignacio Martínez Capella, Borja Arroyo Galende, Tomas Korim, Pernille Øland, Martin Lysbjerg Borup, Anja Rådberg Frederiksen, Amir Ranjouriheravi, Ahmed Faris Al-Jwadi, Mostafa Mansour, Sara Hansen, Isabella Diethelm, Marta Burek, Federico Alvarez, Anders Glent Buch, Nima Mojtahedi, Richard Röttger, Eivind Antonsen Segtnan
Individual testing of samples is time- and cost-intensive, particularly during an ongoing pandemic. Better practical alternatives to individual testing can significantly decrease the burden of disease on the healthcare system. Herein, we presented the clinical validation of Segtnan™ on 3929 patients. Segtnan™ is available as a mobile application entailing an AI-integrated personalized risk assessment approach with a novel data-driven equation for pooling of biological samples. The AI was selected from a comparison between 15 machine learning classifiers (highest accuracy = 80...
April 17, 2024: Scientific Reports
#32
JOURNAL ARTICLE
Alvaro Sanchez, Jose Ignacio Pijoan, Rita Sainz de Rozas, Itxasne Lekue, Ricardo San Vicente, Jose Antonio Quindimil, Rafael Rotaeche, Arritxu Etxeberria, Carmela Mozo, Monica Martinez-Cengotitabengoa, Monica Monge, Cristina Gómez-Ramírez, Ricardo Samper, Mikel Ogueta Lana, Sara Celorrio, Nerea Merino-Inda, Marta Llarena, Marta Gonzalez Saenz de Tejada, Arturo García-Alvarez, Gonzalo Grandes
INTRODUCTION: This study aims to reduce potentially inappropriate prescribing (PIP) of statins and foster healthy lifestyle promotion in cardiovascular disease (CVD) primary prevention in low-risk patients. To this end, we will compare the effectiveness and feasibility of several de-implementation strategies developed following the structured design process of the Behaviour Change Wheel targeting key determinants of the clinical decision-making process in CVD prevention. METHODS AND ANALYSIS: A cluster randomised implementation trial, with an additional control group, will be launched, involving family physicians (FPs) from 13 Integrated Healthcare Organisations (IHOs) of Osakidetza-Basque Health Service with non-zero incidence rates of PIP of statins in 2021...
April 17, 2024: BMJ Open
#33
JOURNAL ARTICLE
Celia Gomar, Claudia Augusta Di Trani, Angela Bella, Leire Arrizabalaga, Jose Gonzalez-Gomariz, Myriam Fernandez-Sendin, Maite Alvarez, Joan Salvador Russo-Cabrera, Nuria Ardaiz, Fernando Aranda, Timo Schippers, Marisol Quintero, Ignacio Melero, Klaus K Orlinger, Henning Lauterbach, Pedro Berraondo
BACKGROUND: Lymphocytic choriomeningitis virus (LCMV) belongs to the Arenavirus family known for inducing strong cytotoxic T-cell responses in both mice and humans. LCMV has been engineered for the development of cancer immunotherapies, currently undergoing evaluation in phase I/II clinical trials. Initial findings have demonstrated safety and an exceptional ability to activate and expand tumor-specific T lymphocytes. Combination strategies to maximize the antitumor effectiveness of LCMV-based immunotherapies are being explored...
April 16, 2024: Journal for Immunotherapy of Cancer
#34
JOURNAL ARTICLE
Gonzalo Sánchez-Tabernero, Antonio R Hidalgo-Muñoz, José Ignacio Galán, Carmen Tabernero
The energy crisis caused by the lack of supply from some countries involved in armed conflicts, coupled with society's continuous demand for energy production, is leading to the proposal of new energy sources, such as the development of uranium mines to increase nuclear energy production. Mine projects (MPs) trigger numerous conflicts in the local societies involved. While for some people, they represent an opportunity for development and benefits, for others these proposals are perceived as a threat and a health risk...
April 16, 2024: Journal of Environmental Management
#35
JOURNAL ARTICLE
Neeltje Steeghs, Carlos Gomez-Roca, Kristoffer S Rohrberg, Morten Mau-Sørensen, Debbie Robbrecht, Josep Tabernero, Samreen Ahmed, Maria E Rodriguez-Ruiz, Caroline Ardeshir, Daniela Schmid, Nassim Sleiman, Carl Watson, Hanna Piper-Lepoutre, David Dejardin, Stefan Evers, Christophe Boetsch, Jehad Charo, Volker Teichgräber, Ignacio Melero
PURPOSE: Simlukafusp alfa (FAP-IL2v), a tumor-targeted immunocytokine, comprising an interleukin-2 variant moiety with abolished CD25 binding fused to human immunoglobulin G1, is directed against fibroblast activation protein-α. This phase I, open-label, multicenter, dose-escalation and extension study (NCT02627274) evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of FAP-IL2v in patients with advanced/metastatic solid tumors. METHODS: Participants received FAP-IL2v intravenously once weekly...
April 17, 2024: Clinical Cancer Research
#36
JOURNAL ARTICLE
Alvaro Teijeira, Saray Garasa, Maria C Ochoa, Sandra Sanchez-Gregorio, Gabriel Gomis, Carlos Luri-Rey, Rafael Martinez-Monge, Beatrice Pinci, Karmele Valencia, Belen Palencia, Benigno Barbes, Elixabet Bolanos, Arantza Azpilikueta, Marina Garcia-Cardosa, Javier Burguete, Iñaki Eguren-Santamaria, Eneko Garate-Soraluze, Pedro Berraondo, Jose L Perez-Gracia, Carlos E de Andrea, Maria E Rodriguez-Ruiz, Ignacio Melero
PURPOSE: Cancer patients frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observation that such low doses of ionizing radiation are able to induce neutrophils to extrude neutrophil extracellular traps (NETs), we have investigated the mechanisms, consequences and the occurrence of such phenomena in patients undergoing radiotherapy. EXPERIMENTAL DESIGN: NETosis was analyzed in cultures of neutrophils isolated from healthy donors, cancer patients and cancer-bearing mice under confocal microscopy...
April 17, 2024: Clinical Cancer Research
#37
JOURNAL ARTICLE
Claudia Pestchanker, Brenda Bertado Cortez, Marco A Lana Peixoto, José Ignacio Gortari, Sheila Castro Suarez, Cesar Caparo Zamalloa, Graciana Galiana, Francisco Peñalver, Vanesa Daccach Marques, Katharina Messias, Lorna Galleguillos, Fernando García, Juan I Rojas, Liliana Patrucco, Edgardo Cristiano, Verónica Tkachuk, Susana Liwacki, Jorge Correale, Mariano Marrodan, María C Ysraelit, Carlos Vrech, Norma Deri, Felisa Leguizamon, Darío Tavolini, Carolina Mainella, Gisela Zanga, Marina Alonso Serena, Ethel Ciampi, Herval Ribeiro Soares Neto, Pablo Lopez, Edgar Carnero Contentti
INTRODUCTION: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory activity and prognostic factors of APS severity in a real-world setting. METHODS: We conducted a retrospective study on a cohort of Latin American (LATAM) NMOSD patients who had experienced APS during their follow-up. Patients from Mexico, Peru, Brazil, Colombia, Panama, Chile and Argentina patients who met 2015 NMOSD criteria were included...
April 17, 2024: Journal of Neurology
#38
JOURNAL ARTICLE
Bright Huo, Elisa Calabrese, Patricia Sylla, Sunjay Kumar, Romeo C Ignacio, Rodolfo Oviedo, Imran Hassan, Bethany J Slater, Andreas Kaiser, Danielle S Walsh, Wesley Vosburg
BACKGROUND: Large language model (LLM)-linked chatbots may be an efficient source of clinical recommendations for healthcare providers and patients. This study evaluated the performance of LLM-linked chatbots in providing recommendations for the surgical management of gastroesophageal reflux disease (GERD). METHODS: Nine patient cases were created based on key questions addressed by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) guidelines for the surgical treatment of GERD...
April 17, 2024: Surgical Endoscopy
#39
REVIEW
José Javier San Román Llorens, Marta Fernández-Gurria, June Artaechevarria Artieda, Nicolas Alejandre Alba, Blanca García Sandoval, Ignacio Jiménez-Alfaro Morote
PURPOSE: To analyze the efficacy, safety and cost-effectiveness of adjuvant therapy with 5-fluorouracil (5-FU) compared to interferon α-2b (IFNα-2b) after surgery in ocular surface squamous neoplasia (OSSN). METHODS: Retrospective study that included patients diagnosed with OSSN, who underwent surgical excision followed by adjuvant therapy with IFN α-2b (Group A) or 5-FU (Group B), in a tertial referral hospital. Clinical data collected included: demographics, risk factors, appearance, size and location of the lesions, slit-lamp examination, anterior segment optical coherence tomography, iconography and histological classification of subtypes of OSSN...
April 17, 2024: International Ophthalmology
#40
JOURNAL ARTICLE
Po-Yang Tsou, Ignacio E Tapia
STUDY OBJECTIVES: Congenital central hypoventilation syndrome (CCHS) is a rare disease predisposing children to respiratory failure due to abnormal ventilatory drive. Variability in hypoventilation and respiratory support need have been reported. We aim to identify clinical variables associated with incident tracheostomy and common etiologies of hospitalization among children with CCHS. METHODS: Hospital discharge records were obtained for children (<21 years) with CCHS hospitalized between 2006 and 2019 from the Kid's Inpatient Database...
April 17, 2024: Pediatric Pulmonology
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