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https://www.readbyqxmd.com/read/29341304/enantioselective-synthesis-of-aminodiols-by-sequential-rh-catalysed-oxyamination-kinetic-resolution-expanding-the-substrate-scope-of-amidine-based-catalysis
#1
Joan Guasch, Irene Giménez, Ignacio Funes-Ardoiz, Isabel Matheu, Feliu Maseras, Sergio Castillón, Yolanda Díaz, Miguel Bernús
Regio- and stereoselective oxyamination of dienes through a tandem rhodium catalysed aziridination-nucleophilic opening affords racemic oxazolidinone derivatives, which undergo a kinetic resolution acylation process using ABCs (amidine-based catalysts) achieving s values up to 117. This protocol was applied to the enantioselective synthesis of sphingosine.
January 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29341114/recombinant-human-hepatocyte-growth-factor-provides-protective-effects-in-celurein-induced-acute-pancreatitis-in-mice
#2
Mayrel Palestino-Domínguez, Mario Pelaez-Luna, Roberto Lazzarini-Lechuga, Ignacio Rodríguez-Ochoa, Verónica Souza, Roxana U Miranda, Benjamín Pérez-Aguilar, Leticia Bucio, Jens U Marquardt, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz
Acute pancreatitis is a multifactorial disease associated with profound changes of the pancreas induced by release of digestive enzymes that lead to increase in proinflammatory cytokine production, excessive tissue necrosis, edema, and bleeding. Elevated levels of hepatocyte growth factor (HGF) and its receptor c-Met have been observed in different chronic and acute pancreatic diseases including experimental models of acute pancreatitis. In the present study, we investigated the protective effects induced by the recombinant human HGF in a mouse model of cerulein-induced acute pancreatitis...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29340914/structural-effects-on-hiv-risk-among-youth-a-multi-level-analysis
#3
Robin Lin Miller, Trevor Strzyzykowski, Kyung-Sook Lee, Danielle Chiaramonte, Ignacio Acevedo-Polakovich, Hannah Spring, Olga Santiago-Rivera, Cherrie B Boyer, Jonathan M Ellen
We proposed a multilevel model of structural influences on HIV-risky sexual partnerships in a diverse sample of 1793 youth residing in 23 states and the District of Columbia. We examined the influence of concentrated disadvantage, HIV stigma, and sexual and gender minority stigma on engagement in HIV risky sexual partnerships and whether youth's participation in opportunity structures, anticipation of HIV stigma, and perceptions of their community as youth-supportive settings mediated structural effects. After controlling for age, HIV status, and race, we found structural HIV stigma had deleterious indirect effects on youth's participation in HIV-risky sexual partnerships...
January 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29340794/a-unified-description-of-colloidal-thermophoresis
#4
REVIEW
Jérôme Burelbach, Daan Frenkel, Ignacio Pagonabarraga, Erika Eiser
We use the dynamic length and time scale separation in suspensions to formulate a general description of colloidal thermophoresis. Our approach allows an unambiguous definition of separate contributions to the colloidal flux and clarifies the physical mechanisms behind non-equilibrium motion of colloids. In particular, we derive an expression for the interfacial force density that drives single-particle thermophoresis in non-ideal fluids. The issuing relations for the transport coefficients explicitly show that interfacial thermophoresis has a hydrodynamic character that cannot be explained by a purely thermodynamic consideration...
January 16, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29340707/vrk1-and-aurkb-form-a-complex-that-cross-inhibit-their-kinase-activity-and-the-phosphorylation-of-histone-h3-in-the-progression-of-mitosis
#5
David S Moura, Ignacio Campillo-Marcos, Marta Vázquez-Cedeira, Pedro A Lazo
Regulation of cell division requires the integration of signals implicated in chromatin reorganization and coordination of its sequential changes in mitosis. Vaccinia-related kinase 1 (VRK1) and Aurora B (AURKB) are two nuclear kinases involved in different steps of cell division. We have studied whether there is any functional connection between these two nuclear kinases, which phosphorylate histone H3 in Thr3 and Ser10, respectively. VRK1 and AURKB are able to form a stable protein complex, which represents only a minor subpopulation of each kinase within the cell and is detected following nocodazole release...
January 16, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29340291/erratum-endoscopic-esophagogastric-anastomosis-with-luminal-apposition-axios-stent-las-approach-a-new-concept-for-hybrid-lewis-santy
#6
Adrian Culetto, Jean-Michel Gonzalez, Geoffroy Vanbiervliet, Pablo Miranda Garcia, Juan Ignacio Tellechea, Emmanuelle Garnier, Stephane Berdah, Marc Barthet
[This corrects the article DOI: 10.1055/s-0043-106577.].
June 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29340061/analysis-of-the-mutational-landscape-of-classic-hodgkin-lymphoma-identifies-disease-heterogeneity-and-potential-therapeutic-targets
#7
Elena Mata, Antonio Díaz-López, Ana M Martín-Moreno, Margarita Sánchez-Beato, Ignacio Varela, María J Mestre, Carlos Santonja, Fernando Burgos, Javier Menárguez, Mónica Estévez, Mariano Provencio, Beatriz Sánchez-Espiridión, Eva Díaz, Carlos Montalbán, Miguel A Piris, Juan F García
Defining the mutational landscape of classic Hodgkin lymphoma is still a major research goal. New targeted next-generation sequencing (NGS) techniques may identify pathogenic mechanisms and new therapeutic opportunities related to this disease. We describe the mutational profile of a series of 57 cHL cases, enriched in Hodgkin and Reed-Sternberg (HRS) cells. Overall, the results confirm the presence of strong genomic heterogeneity. However, several variants were consistently detected in genes related to relevant signaling pathways, such as GM-CSF/IL-3, CBP/EP300, JAK/STAT, NF-kappaB, and numerous variants of genes affecting the B-cell receptor (BCR) pathway, such as BTK, CARD11, BCL10, among others...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339600/scaling-up-and-kinetic-model-validation-of-direct-black-22-degradation-by-immobilized-penicillium-chrysogenum
#8
Ignacio Durruty, Jorge Froilán González, Erika Alejandra Wolski
This research was undertaken to develop tools that facilitate the industrial application of an immobilized loofah-fungi system to degrade Direct Black 22 (DB22) azo dye. In laboratory-scale tests, the DB22, and loofah as support, were used. Assays without loofah were used as a free-cells control. The use of natural carriers to facilitate adhesion and growth of the fungi has shown favorable results. The degradation rate of immobilized cells increased twice as compared to free-cells control. At day 5 the decolorization was almost complete, while without loofah the total decolorization took more than 10 days...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29338655/the-alchemical-manuscripts-of-david-lindsay-1587-1641-lord-lindsay-of-balcarres
#9
Ignacio-Miguel Pascual-Valderrama, Joaquín Pérez-Pariente
The private book collection of David Lindsay, First Lord Lindsay of Balcarres (1587-1641), was one of the largest in early modern Scotland. Despite being dispersed during the following three centuries, this collection still provides evidence for Lindsay's scientific interests and approach to the study of alchemy. In this paper we seek to partially reconstruct his library by describing and, where possible, identifying the sources of Lindsay's own transcriptions of alchemical texts, as well as works mentioned in a book-list written in his hand...
August 2017: Ambix
https://www.readbyqxmd.com/read/29338607/immunotherapies-in-transplantation-and-cancer-22nd-nat-meeting-2nd-nat-labex-igo-joint-meeting-1-2-june-2017-nantes-france
#10
Sylvain Simon, Maud Charpentier, Ignacio Anegon, Nathalie Labarriere
This 22nd edition of the Nantes Actualités Transplantation annual meeting was co-organized for the second time with the LabEx Immuno-Graft Oncology network. This international meeting was held on 1 and 2 June 2017 in Nantes (western France). The topic of this 2-day meeting was 'Immunotherapies in transplantation and cancer'. This meeting brought together 17 international invited speakers, young researchers and 220 attendees mainly from Europe and North America. It was a unique opportunity to bring together the pioneers and leading immunologists in the fields of transplantation and cancer, focusing on shared mechanisms that control immune responses in organ or bone marrow transplantation and in cancer...
September 2017: Immunotherapy
https://www.readbyqxmd.com/read/29338349/a-multistep-docking-and-scoring-protocol-for-congeneric-series-implementation-on-kinase-dfg-out-type-ii-inhibitors
#11
José M Granadino-Roldán, Andrés Garzón, Patricia Gomez-Gutierrez, Ignacio Pasamontes-Funez, Maria Santos Tomas, Jaime Rubio-Martinez
AIM: Rescoring of docking-binding poses can significantly improve molecular docking results. Our aim was to evaluate postprocessing docking protocols in order to determine the most suitable methodology for the study of the binding of congeneric compounds to protein kinases. MATERIALS & METHODS: Diverse ligand-receptor poses generated after docking were submitted to different relaxation protocols. The Molecular Mechanics Poisson-Boltzmann (Generalized Born) Surface Area approach was applied for the evaluation of the binding affinity of complexes obtained...
January 17, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29338039/stat3-expression-by-myeloid-cells-is-detrimental-for-the-t-cell-mediated-control-of-infection-with-mycobacterium-tuberculosis
#12
Yu Gao, Juan Ignacio Basile, Cajsa Classon, Dolores Gavier-Widen, Akihiko Yoshimura, Berit Carow, Martin E Rottenberg
STAT3 is a master regulator of the immune responses. Here we show that M. tuberculosis-infected stat3fl/fl lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but higher levels of pulmonary neutrophils. STAT3-deficient macrophages showed no improved control of intracellular mycobacterial growth. Instead, protection associated to elevated ability of stat3fl/fl lysm cre antigen-presenting cells (APCs) to release IL-6 and IL-23 and to stimulate IL-17 secretion by mycobacteria-specific T cells...
January 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29337559/totally-organic-redox-active-ph-sensitive-nanoparticles-stabilized-by-amphiphilic-aromatic-polyketones
#13
Esteban Araya-Hermosilla, José Catalán-Toledo, Fabian Muñoz-Suescun, Felipe Oyarzun-Ampuero, Patrizio Raffa, Lorenzo Massimo Polgar, Francesco Picchioni, Ignacio Moreno-Villoslada
Amphiphilic aromatic polymers have been synthesized by grafting aliphatic polyketones with 4-(aminomethyl)benzoic acid at different molar ratios via the Paal-Knorr reaction. The resulting polymers, showing diketone conversion degree of 16, 37, 53, and 69 %, have been complexed with the redox-active 2,3,5-triphenyl-2H-tetrazolium chloride, precursor molecule with which aromatic-aromatic interactions are held. Upon addition of ascorbic acid to the complexes, in-situ reduction of the tetrazolium salt produced 1,3,5-triphenylformazan nanoparticles stabilized by the amphiphilic polymers...
January 16, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29336343/-on-line-learning-in-urologic-surgery-the-value-of-the-2-0-web-tools
#14
Ignacio T Castillón Vela
The field of Surgery is under the pressure of accelerated change where technological cycles get shorter and shorter, sometimes transformational. Learning and training have gotten a key role because learning curves for new techniques directly affect patient's safety and learning cycles are slower. The traditional learning model within the urology department is overwhelmed. We need new training and learning methods. The aim of this article is to perform a critical analysis of the current status of learning in urological surgery and the challenges we face, evaluating how new information and communication technologies can help us to facilitate the learning process...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29335230/application-of-a-health-risk-assessment-model-for-cattle-exposed-to-pesticides-in-contaminated-drinking-waters-a-study-case-from-the-pampas-region-argentina
#15
Sabrina Dubny, Fabio Peluso, Ignacio Masson, Natalia Othax, José González Castelain
Using the USEPA methodology we estimated the probabilistic chronic risks for calves and adult cows due to pesticide exposure through oral intake of contaminated surface and ground waters in Tres Arroyos County (Argentina). Because published data on pesticide toxicity endpoints for cows are scarce, we used threshold levels based on interspecies extrapolation methods. The studied waters showed acceptable quality for cattle production since none of the pesticides were present at high-enough concentrations to potentially affect cow health...
January 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29334470/heterologous-expression-of-rhizobial-celc2-cellulase-impairs-symbiotic-signaling-and-nodulation-in-medicago-truncatula
#16
Marta Robledo, Esther Menéndez, Jose Ignacio Jimenez-Zurdo, Raúl Rivas, Encarna Velazquez, Eustoquio Martinez-Molina, Giles Oldroyd, Pedro F Mateos
The infection of legume plants by rhizobia is tightly regulated to ensure accurate bacterial penetration, infection and development of functionally efficient nitrogen-fixing root nodules. Rhizobial Nod Factors (NF) have key roles in the elicitation of nodulation signalling. Infection of white clover roots also involves the tightly regulated specific breakdown of the non-crystalline apex of cell walls in growing root hairs, which is mediated by Rhizobium leguminosarum bv. trifolii cellulase CelC2. Here, we have analyzed the impact of this endoglucanase on symbiotic signalling in the model legume Medicago truncatula...
January 15, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29334403/soft-tissue-volume-gain-around-dental-implants-using-autogenous-subepithelial-connective-tissue-grafts-harvested-from-the-lateral-palate-or-tuberosity-area-a-randomized-controlled-clinical-study
#17
Ernest Rojo, Giorgio Stroppa, Ignacio Sanz-Martin, Oscar Gonzalez-Martín, Antonio Santos Alemany, José Nart
AIM: To compare the soft tissue volume gain (VG) around single tooth implants with subepithelial connective tissue graft (SCTG) from either the lateral palate (LP) or from the tuberosity area (TA). METHODS: 32 patients with 36 implants with buccal volume deficiencies were randomly assigned to receive SCTG from LP (control group/CG) or TA (test group/TG). Clinical parameters were recorded and volume gain was evaluated by STL image superimposition of 2 intraoral scans (baseline/BL and 3 months after surgery/FU-3)...
January 15, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29333833/-infrequent-mutation-in-renal-coloboma-syndrome-case-report-and-review
#18
Ignacio Ruiz Del Olmo Izuzquiza, Yolanda Romero Salas, Ana Rodríguez Valle, Inmaculada González Viejo, María L Justa Roldán
Renal-coloboma syndrome is an autosomal dominant disease characterized by renal hypodysplasia and coloboma. A case of a 12-year-old girl with chronic kidney disease, bilateral optic nerve colobomas and an exceptional PAX-2 gene mutation is presented. Diagnosed in prenatal scans with bilateral renal hypoplasia, she presented clinical and laboratory findings of chronic kidney disease at 5 days of life. Following tests showed grade II bilateral vesicoureteral reflux spontaneously solved, maintained non nephrotic proteinuria controlled with enalapril and bilateral colobomas with left macular atrophy...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29331229/hominin-raw-material-procurement-in-the-oldowan-acheulean-transition-at-olduvai-gorge
#19
Lindsay J McHenry, Ignacio de la Torre
The lithic assemblages at the Oldowan-Acheulean transition in Bed II of Olduvai Gorge, Tanzania, represent a wide variety of raw materials reflecting both the diversity of volcanic, metamorphic, and sedimentary source materials available in the Olduvai basin and surroundings and the preferences of the tool-makers. A geochemical and petrographic systematic analysis of lava-derived archaeological stone tools, combined with textural and mineralogical characterization of quartzite, chert, and other metamorphic and sedimentary raw materials from two Middle and Upper Bed II sites, has enabled us to produce a comprehensive dataset and characterization of the rocks employed by Olduvai hominins, which is used here to establish a referential framework for future studies on Early Stone Age raw material provenancing...
January 10, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29330796/monitoring-functional-responses-to-hypoxia-in-single-carotid-body-cells
#20
Ana María Muñoz-Cabello, Hortensia Torres-Torrelo, Ignacio Arias-Mayenco, Patricia Ortega-Sáenz, José López-Barneo
The carotid body is the main arterial chemoreceptor in mammals that mediates the cardiorespiratory reflexes activated by acute hypoxia. Here we describe the protocols followed in our laboratory to study responsiveness to hypoxia of single, enzymatically dispersed, glomus cells monitored by microfluorimetry and the patch-clamp technique.
2018: Methods in Molecular Biology
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