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cannabis use disorder

Jane Metrik, Rachel L Gunn, Kristina M Jackson, Alexander W Sokolovsky, Brian Borsari
BACKGROUND: The study aims were to examine daily associations between marijuana and alcohol use and the extent to which the association differs as a function of cannabis use disorder (CUD) and/or alcohol use disorder (AUD) diagnosis. METHODS: Timeline Followback interview data collected in a study of veterans (N=127) recruited from a Veterans Affairs hospital who reported at least one day of co-use of marijuana and alcohol in the past 180 days (22,860 observations)...
April 15, 2018: Alcoholism, Clinical and Experimental Research
Ran Barzilay, Monica E Calkins, Tyler M Moore, Daniel H Wolf, Theodore D Satterthwaite, J Cobb Scott, Jason D Jones, Tami D Benton, Ruben C Gur, Raquel E Gur
BACKGROUND: Traumatic stressors during childhood and adolescence are associated with psychopathology, mostly studied in the context of post-traumatic stress disorder (PTSD) and depression. We investigated broader associations of traumatic stress exposure with psychopathology and cognition in a youth community sample. METHODS: The Philadelphia Neurodevelopmental Cohort (N = 9498) is an investigation of clinical and neurobehavioral phenotypes in a diverse (56% Caucasian, 33% African American, 11% other) US youth community population (aged 8-21)...
April 15, 2018: Psychological Medicine
Emily Karsinti, Kristel Piani, El Hedi Zerdazi, Uwe Maskos, Philippe Faure, Lucia Romo, Frank Bellivier, Georges Brousse, Jean Pierre Lépine, Vanessa Bloch, Florence Vorspan
Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21...
March 29, 2018: Psychiatry Research
Kristine Rømer Thomsen, Mette Buhl Callesen, Morten Hesse, Timo Lehmann Kvamme, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Valerie Voon
Background and aims Impulsivity is a risk factor for addictive behaviors. The UPPS-P impulsivity model has been associated with substance addiction and gambling disorder, but its role in other non-substance addiction-related behaviors is less understood. We sought to examine associations between UPPS-P impulsivity traits and indicators of multiple substance and non-substance addiction-related behaviors in youth with varying involvement in these behaviors. Methods Participants (N = 109, aged 16-26 years, 69% males) were selected from a national survey based on their level of externalizing problems to achieve a broad distribution of involvement in addiction-related behaviors...
April 12, 2018: Journal of Behavioral Addictions
Hila Abush, Subroto Ghose, Erin A Van Enkevort, Brett A Clementz, Godfrey D Pearlson, John A Sweeney, Matcheri S Keshavan, Carol A Tamminga, Elena I Ivleva
Associations between cannabis use and psychotic disorders suggest that cannabis may be a contributory risk factor in the neurobiology of psychosis. In this study, we examined brain structure characteristics, total and regional gray matter density (GMD), using Voxel Based Morphometry, in psychotic individuals, stratified by history of cannabis use (total n = 109). We also contrasted GMD estimates in individual diagnostic groups (schizophrenia/bipolar I disorder) with and without history of adolescent cannabis use (ACU)...
March 28, 2018: Psychiatry Research
Malahat Khalili, Afarin Rahimi-Movaghar, Behrang Shadloo, Ramin Mojtabai, Karl Mann, Masoumeh Amin-Esmaeili
AIMS: Addiction science has made great progress in the past decades. We conducted a scientometric study in order to quantify the number of publications and the growth rate globally, regionally, and at country levels. METHODS: In October 2015, we searched the Scopus database using the general keywords of addiction or drug-use disorders combined with specific terms regarding 4 groups of illicit drugs - cannabis, opioids, cocaine, and other stimulants or hallucinogens...
April 6, 2018: European Addiction Research
Francisco Navarrete, Auxiliadora Aracil-Fernández, Jorge Manzanares
BACKGROUND AND PURPOSE: Cannabidiol (CBD) represents a promising therapeutic tool for treating cannabis use disorder (CUD). This study aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous cannabinoid withdrawal. EXPERIMENTAL APPROACH: Spontaneous cannabinoid withdrawal was evaluated 12 h after cessation of CP-55,940 treatment (0.5 mg·kg-1 /12 h; intraperitoneally (i.p.); 7 days) in C57BL/6J mice. The effects of CBD (5, 10 and 20 mg·kg-1 ; i...
April 6, 2018: British Journal of Pharmacology
Romain Torrents, Jean Francois Ferré, Annie Konareff, Patrice Hemery, Kenneth Sherwin, Christian Lassalle, Nicolas Simon, Sami Scerra
BACKGROUND: Trihexyphenidyl (THP) is an anticholinergic drug misused to procure hallucination, sedation, and anxiolysis. The aim of this cohort was to show and describe, within a public health risk management policy, the risks of a long-standing but relatively unknown addiction: THP addiction. METHODS: On Réunion island, a cohort with systematic data collection has been set up by addictologists working in the Centres for Addiction Prevention and Treatment, in the university hospital, and in general practices who have active lists of patients misusing THP...
April 3, 2018: Journal of Clinical Psychopharmacology
Tania Da Silva, Sina Hafizi, Ana C Andreazza, Michael Kiang, R Michael Bagby, Efren Navas, Isabelle Laksono, Peter Truong, Cory Gerritsen, Ivana Prce, Napapon Sailasuta, Romina Mizrahi
Introduction: Oxidative stress and glutathione dysregulation have been implicated in the etiology of schizophrenia. To date, most in vivo studies have investigated alterations in cerebral glutathione levels in patients in which the disorder is already established; however, whether oxidative stress actually predates the onset of psychosis remains unknown. In the current study, we investigated cerebral glutathione levels of antipsychotic-naïve individuals at clinical high risk for psychosis...
April 1, 2018: International Journal of Neuropsychopharmacology
Corinne Vannimenus, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Florence Richard, Benjamin Rolland
BACKGROUND: Active smoking at the time of diagnosis of a first head & neck (H&N) or lung cancer is associated with a worse cancer outcome and increased mortality. However, the compared characteristics of active vs. former smokers at cancer diagnosis are poorly known. METHODS: In 371 subjects with a first H&N or lung cancer, we assessed: 1) socio-demographic features; 2) lifelong types of smoking; 3) alcohol use disorder identification test (AUDIT); 4) cannabis abuse screening test (CAST); and 5) Mini International Neuropsychiatric Interview (MINI)...
April 3, 2018: BMC Cancer
Michael J Mason, Jeremy Mennis
BACKGROUND: An understudied, yet important area of youth development research is the examination of how place affects critical psychosocial processes such as identity formation, problem solving, emotional regulation, and in particular with adolescents, belongingness, autonomy, social competency, and behavioral health. A growing spatially informed literature indicates that youth interact with meaningful places as environmental strategies, shaping developmental trajectories related to behavioral health...
April 2, 2018: Substance Use & Misuse
Tabea Schoeler, Delphine Theobald, Jean-Baptiste Pingault, David P Farrington, Jeremy W Coid, Sagnik Bhattacharyya
BACKGROUND: Evidence regarding the association between cannabis use and depression remain conflicting, especially as studies have not typically adopted a longitudinal design with a follow-up period that was long enough to adequately cover the risk period for onset of depression. METHOD: Males from the Cambridge Study in Delinquent Development (CSDD) (N = 285) were assessed seven times from age 8 to 48 years to prospectively investigate the association between cannabis use and risk of major depressive disorder (MDD)...
April 2, 2018: Psychological Medicine
Ofir Livne, Liat Razon, Jürgen Rehm, Deborah S Hasin, Shaul Lev-Ran
BACKGROUND: Though high rates of co-occurring cannabis use and depression are well-documented, data regarding the association between cannabis use and dysthymia is scarce. The aim of this cross-sectional study was to explore clinical correlations of cannabis use among individuals with dysthymia, as well as the changes in the association between cannabis use and dysthymia across six decades of birth cohorts. METHODS: Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III; 2012-2013; N = 36,309)...
March 16, 2018: Journal of Affective Disorders
Thomas J Abbruscato, Paul C Trippier
Methamphetamine has the second highest prevalence of drug abuse after cannabis, with estimates of 35 million users worldwide. The (S)-(+)-enantiomer is the illicit drug, active neurostimulant and eutomer, while the (R)-(-)-enantiomer is contained in over the counter decongestants. While designated a schedule II drug in 1970, (S)-(+)-methamphetamine is available by prescription for the treatment of attention-deficit disorder and obesity. The illicit use of (S)-(+)-methamphetamine results in the sudden 'rush' of stimulation to the motivation, movement, pleasure and reward centers in the brain, caused by rapid release of dopamine...
March 30, 2018: ACS Chemical Neuroscience
Michele Bedard-Gilligan, Natalia Garcia, Lori A Zoellner, Norah C Feeny
The co-occurrence of posttraumatic stress disorder (PTSD) and substance use is related to poorer outcome and increased dropout from trauma-focused treatment. Investigating PTSD and substance use can inform the intervention approaches. Exploring cannabis use in particular is especially important because rates of cannabis use have been increasing with recent legalization trends. A better understanding of how substance use is associated with treatment processes and outcome for individuals with PTSD is needed to enhance care...
March 29, 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Musa Basseer Sami, Sagnik Bhattacharyya
A substantial body of credible evidence has accumulated that suggest that cannabis use is an important potentially preventable risk factor for the development of psychotic illness and its worse prognosis following the onset of psychosis. Here we summarize the relevant evidence to argue that the time has come to investigate the neurobiological effects of cannabis in patients with psychotic disorders. In the first section we summarize evidence from longitudinal studies that controlled for a range of potential confounders of the association of cannabis use with increased risk of developing psychotic disorders, increased risk of hospitalization, frequent and longer hospital stays, and failure of treatment with medications for psychosis in those with established illness...
March 1, 2018: Journal of Psychopharmacology
Debasish Basu, Abhishek Ghosh, Siddharth Sarkar, Bichitra Nanda Patra, B N Subodh, Surendra Kumar Mattoo
Background & objectives: Dropout from substance use disorders treatment is associated with poor outcomes. Although many factors have been associated with an early dropout of patients, the reasons for dropping out of treatment prematurely remain poorly understood particularly in the Indian context. This study was aimed to study socio-demographic and clinical variables predicting initial dropout of patients attending a tertiary care de-addiction treatment centre in north India. Methods: Information was extracted from the records of consecutive newly registered patients from January 2011 to December 2014...
November 2017: Indian Journal of Medical Research
Michel Arvidsson, Shahid Ullah, Johan Franck, Marja-Liisa Dahl, Olof Beck
In the treatment of substance use disorder regular laboratory-based testing has the dual purpose of monitoring compliance to the prescribed medication and the abstention from medically non-motivated substances (i.e. drug abuse screening). The principal specimen for testing is urine, but collection of urine has some disadvantages, e.g. being more time-consuming and more intrusive compared to other matrices, and there is also the risk of adulteration. This project aims to compare exhaled breath and oral fluid as alternative matrices for drug abuse screening in patients with substance use disorder...
March 25, 2018: Drug Testing and Analysis
Andrea H Weinberger, Jonathan Platt, Jan Copeland, Renee D Goodwin
OBJECTIVE: The current study prospectively investigated the relationship between cannabis use and cigarette smoking initiation, persistence, and relapse during a 3-year period among adults in the United States. METHODS: Analyses included respondents who completed Waves 1 (2001-2002) and 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions and responded to questions about cannabis use and smoking status (n = 34,639). Multivariable logistic regression models were used to calculate the odds of cigarette use at Wave 2 among Wave 1 daily smokers, nondaily smokers, former smokers, and nonsmokers by Wave 1 cannabis use...
March 6, 2018: Journal of Clinical Psychiatry
Beth Han, Wilson M Compton, Carlos Blanco, Christopher M Jones
BACKGROUND: Trends in and correlates of medical marijuana use are important to inform ongoing clinical, research, policy, and programmatic efforts. This study assessed trends in and correlates of medical marijuana use among U.S. adults. METHODS: We analyzed data from approximately 147,200 U.S. civilians aged 18 or older who participated in the 2013-2015 National Surveys on Drug Use and Health. Descriptive analyses, multivariable logistic regressions, and zero-truncated native binomial regressions were applied...
March 14, 2018: Drug and Alcohol Dependence
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