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https://www.readbyqxmd.com/read/28763519/effects-of-nandrolone-decanoate-on-time-to-consolidation-of-bone-defects-resulting-from-osteotomy-for-tibial-tuberosity-advancement
#1
Danilo R C Marques, Danilo Marques, Jose F Ibanez, Itallo B Freitas, Ana C Hespanha, Juliana F Monteiro, Mayara Eggert, Amanda Becker
STUDY DESIGN: Experimental study. OBJECTIVE: The aim of this study was to evaluate the effect of nandrolone decanoate (ND) on the time taken for bone consolidation in dogs undergoing tibial tuberosity advancement surgery (TTA). MATERIALS AND METHODS: Seventeen dogs that underwent TTA surgery were randomly divided into two groups: group C (TTA; 9 stifles), and group TTA+ND (TTA and systemic administration of ND; 8 stifles). Three observers (two radiologists and an orthopaedic surgeon), assessed bone consolidation by visual inspection of serial radiographs at intervals of 21 days following surgery...
August 1, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28750791/use-of-nandrolone-decanoate-in-treatment-of-pure-red-cell-aplasia-secondary-to-diclofenac-administration-a-case-report
#2
Paula Nassar de Marchi, André Nanny Le Sueur Vieira, José Francisco Antunes Ribeiro, Silvano Salgueiro Geraldes, Paulo Roberto Rodrigues Ramos, Alessandra Melchert, Priscylla Tatiana Chalfun Guimarães-Okamoto
Pure red cell aplasia (PRCA) is a disorder that leads to a nonregenerative anemia that results from erythroid precursors failing to reach maturity in the bone marrow, whereas the numbers of mature myeloid and megakaryocytic cells remain normal. PRCA can be induced by autoimmune processes, infections, drugs, toxins, and radiation, and is diagnosed by a bone marrow cytology examination after excluding the most common causes of nonregenerative anemia. Immunosuppressive therapies are used to treat PRCA, and usually involve the use of glucocorticoids, cyclosporin, or azathioprine...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28648787/online-turbulent-flow-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry-for-high-throughput-screening-of-anabolic-steroids-in-horse-urine
#3
Hyun Du Shin, Joon Hyuk Suh, Junghyun Kim, Hyun-Deok Cho, Su Duk Lee, Kwan Seok Han, Yu Wang, Sang Beom Han
A high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine by online turbulent flow extraction coupled with liquid chromatography-tandem mass spectrometry was developed. The use of turbulent flow chromatography could simplify pretreatment of horse urine, which has complex matrices as well as high viscosity...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28633515/crystal-structure-and-functional-characterization-of-a-cytochrome-p450-bacyp106a2-from-bacillus-sp-pamc-23377
#4
Ki-Hwa Kim, Chang Woo Lee, Bikash Dangi, Sun-Ha Park, Hyun Park, Tae-Jin Oh, Jun Hyuck Lee
Bacterial cytochrome P450 (CYP) steroid hydroxylases are effectively useful in the pharmaceutical industry for introducing hydroxyl groups to a wide range of steroids. We found a putative CYP steroid hydroxylase (BaCYP106A2) from the bacterium Bacillus sp. PAMC 23377 isolated from Kara Sea of the Arctic Ocean, showing 94% sequence similarity with BmCYP106A2 (Bacillus megaterium ATCC 13368). In this study, soluble BaCYP106A2 was overexpressed to evaluate its substrate-binding activity. The substrate affinity (Kd value) to 4-androstenedione was 387 ± 37 µM...
June 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28582442/the-role-of-neuropeptide-y-in-nandrolone-decanoate-induced-attenuation-of-antidepressant-effect-of-exercise
#5
Jovana Joksimovic, Dragica Selakovic, Milovan Matovic, Ivan Zaletel, Nela Puskas, Gvozden Rosic
Since the increased prevalence of anabolic androgenic steroids abuse in last few decades is usually accompanied by various exercise protocols, the scope of our study was to evaluate the effects of chronic nandrolone decanoate administration in supraphysiological dose and a prolonged swimming protocol (alone and simultaneously with nandrolone decanoate) on depressive state in male rats. Simultaneously, we investigated the possible alterations in neuropeptide Y (NPY) content in blood and the hippocampus, in order to determine the role of NPY in the modulation of depressive-like behavior...
2017: PloS One
https://www.readbyqxmd.com/read/28574610/costamere-protein-expression-and-tissue-composition-of-rotator-cuff-muscle-after-tendon-release-in-sheep
#6
Severin Ruoss, Christoph B Möhl, Mario C Benn, Brigitte von Rechenberg, Karl Wieser, Dominik C Meyer, Christian Gerber, Martin Flück
Previous studies suggested that degradation of contractile tissue requires cleavage of the costamere, a structural protein complex that holds sarcomeres in place. This study examined if costamere turnover is affected by a rotator cuff tear in a previously established ovine model. We found the activity of focal adhesion kinase (FAK), a main regulator of costamere turnover, was unchanged at 2 weeks but decreased by 27% 16 weeks after surgical release of the infraspinatus tendon. This was accompanied by cleavage of the costamere protein talin into a 190 kDa fragment while full length talin remained unchanged...
June 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28544314/low-intensity-endurance-exercise-plus-nandrolone-decanoate-modulates-cardiac-adiponectin-and-its-receptors
#7
A Karimi, S Joukar, H Najafipour, Y Masoumi-Ardakani, B Shahouzehi
Vast adverse effects of anabolic-androgenic steroids (AASs) on athletes' cardiovascular systems have been reported. However, there is still a lack of adequate information regarding the pathways and mechanisms involved. We tested the hypothesis that adiponectin and its receptors in the heart may be affected by long-term use of AASs alongside exercising. Male Wistar rats were randomized into the control (CTL), exercise (EX), nandrolone (Nan), arachis (Arach) group which treated with arachis as vehicle, trained vehicle (EX+Arach) and trained nandrolone (EX+Nan) groups that were treated for 8 weeks...
March 2017: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/28476699/analysis-and-detection-of-microporosities-in-aging-bones-in-context-to-pharmaceutical-treatment-a-study-in-line-of-osteoporosis
#8
Nadeem Baig, Muhammad Zaheer Khan
The objective of the current study was to evaluate the effects of nandrolone decanoate in terms of morphological changes in the diaphyseal region of appendicular skeleton long bone (femur) of aging female Albino rats with the help of innovatively designed histomorphometric tool of study being introduced first time mapped out micro porosities (lacunae) which tend to intensify as part of advanced aging denoting deterioration in osseous tissue. In fact our research trial has been in the line of involutional osteoporosis especially common in post-menopausal aged women, as to find out appropriate drug usefulness in the care and cure of this diseased state as per recommendation of FDA...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28432552/subchronic-nandrolone-administration-reduces-cardiac-oxidative-markers-during-restraint-stress-by-modulating-protein-expression-patterns
#9
Barbara Pergolizzi, Vitina Carriero, Giuliana Abbadessa, Claudia Penna, Paola Berchialla, Silvia De Francia, Enrico Bracco, Silvia Racca
Nandrolone decanoate (ND), an anabolic-androgenic steroid prohibited in collegiate and professional sports, is associated with detrimental cardiovascular effects through redox-dependent mechanisms. We previously observed that high-dose short-term ND administration (15 mg/kg for 2 weeks) did not induce left heart ventricular hypertrophy and, paradoxically, improved postischemic response, whereas chronic ND treatment (5 mg/kg twice a week for 10 weeks) significantly reduced the cardioprotective effect of postconditioning, with an increase in infarct size and a decrease in cardiac performance...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28432434/ventricular-androgenic-anabolic-steroid-related-remodeling-an-immunohistochemical-study
#10
Rossana Cecchi, Barbara Muciaccia, Costantino Ciallella, Natale Mario Di Luca, Akihiko Kimura, Cristina Sestili, Mizuho Nosaka, Toshikazu Kondo
BACKGROUND: Several fatal cases of bodybuilders, following a myocardial infarction after long exposure to androgenic-anabolic steroids (AAS), are reported. In recent years, evidence has emerged of cases of heart failure related to AAS consumption, with no signs of coronary or aorta atherosclerosis. This study aims to further investigate the pathogenesis of the ventricular AAS-related remodeling performing immunohistochemistry (IHC). METHOD: In order to examine innate immunity activity and myocytes and endothelial cell apoptosis, IHC analyses were performed on heart tissue of two cases of bodybuilders who died after years of supratherapeutic use of metelonone and nandrolone and where no atherosclerosis or thrombosis were found, using the following antibodies: anti-CD68, anti-iNOS, anti-CD163, anti-CD 15, anti-CD8, anti-CD4, anti-HIF1 α, and in situ TUNEL staining...
April 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28412309/the-scaffold-protein-rack1-is-a-target-of-endocrine-disrupting-chemicals-edcs-with-important-implication-in-immunity
#11
COMPARATIVE STUDY
Erica Buoso, Marilisa Galasso, Melania Ronfani, Angela Papale, Valentina Galbiati, Ivano Eberini, Marina Marinovich, Marco Racchi, Emanuela Corsini
We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may also be targeted by endocrine disrupting chemicals (EDCs). As a proof of concept, we investigated the effect of the doping agent nandrolone, an androgen receptor (AR) agonist, and of p,p'DDT (dichlorodiphenyltrichloroethane) and its main metabolite p,p'DDE (dichlorodiphenyldichloroethylene), a weak and strong AR antagonist, respectively, on RACK1 expression and innate immune response...
June 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28334510/pharmacokinetics-of-testosterone-cream-applied-to-scrotal-skin
#12
R Iyer, S F Mok, S Savkovic, L Turner, G Fraser, R Desai, V Jayadev, A J Conway, D J Handelsman
Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-over pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate...
July 2017: Andrology
https://www.readbyqxmd.com/read/28322013/evidence-of-boldenone-nandrolone-5-10-estrene-3%C3%AE-17%C3%AE-diol-and-4-estrene-3-17-dione-as-minor-metabolites-of-testosterone-in-equine
#13
Jenny K Y Wong, David K K Leung, Peter Curl, Peter J Schiff, Kenneth K H Lam, Terence S M Wan
The detection of boldenone, nandrolone, 5(10)-estrene-3β,17α-diol and 4-estrene-3,17-dione in a urine sample collected from a gelding having been treated with testosterone (500 mg "Testosterone Suspension 100", single dose, injected intramuscularly) in 2009 led the authors' laboratory to suspect that these 'testicular' steroids could be minor metabolites of testosterone in geldings. Administration trials on six castrated horses with "Testosterone Suspension 100" confirmed that low levels of boldenone, nandrolone, 5(10)-estrene-3β,17α-diol and 4-estrene-3,17-dione could indeed be detected and confirmed in the early post-administration urine samples from all six geldings...
March 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28244681/nandrolone-decanoate-interferes-with-testosterone-biosynthesis-altering-blood-testis-barrier-components
#14
Rosario Barone, Alessandro Pitruzzella, Antonella Marino Gammazza, Francesca Rappa, Monica Salerno, Fulvio Barone, Claudia Sangiorgi, Daniela D'Amico, Nicola Locorotondo, Francesca Di Gaudio, Luigi Cipolloni, Valentina Di Felice, Stefania Schiavone, Venerando Rapisarda, Gabriele Sani, Amos Tambo, Francesco Cappello, Emanuela Turillazzi, Cristoforo Pomara
The aim of this study was to investigate whether nandrolone decanoate (ND) use affects testosterone production and testicular morphology in a model of trained and sedentary mice. A group of mice underwent endurance training while another set led a sedentary lifestyle and were freely mobile within cages. All experimental groups were treated with either ND or peanut oil at different doses for 6 weeks. Testosterone serum levels were measured via liquid chromatography-mass spectrometry. Western blot analysis and quantitative real-time PCR were utilized to determine gene and protein expression levels of the primary enzymes implicated in testosterone biosynthesis and gene expression levels of the blood-testis barrier (BTB) components...
August 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28236045/detection-and-quantification-of-12-anabolic-steroids-and-analogs-in-human-whole-blood-and-20-in-hair-using-lc-hrms-ms-application-to-real-cases
#15
Nicolas Fabresse, Stanislas Grassin-Delyle, Isabelle Etting, Jean-Claude Alvarez
We developed and validated a method to detect and quantify 12 anabolic steroids in blood (androstenedione, dihydrotestosterone, boldenone, epitestosterone, mesterolone, methandienone, nandrolone, stanozolol, norandrostenedione, tamoxifene, testosterone, trenbolone) and eight more in hair samples (nandrolone phenylpropionate, nandrolone decanoate, testosterone propionate, testosterone benzoate, testosterone cypionate, testosterone decanoate, testosterone phenylpropionate, testosterone undecanoate) using liquid chromatography coupled to high-resolution mass spectrometry...
February 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28192127/long-term-treatment-with-nandrolone-decanoate-impairs-mesenteric-vascular-relaxation-in-both-sedentary-and-exercised-female-rats
#16
Izabela F Caliman, Cristian S Bernabe, Antônio F de Melo, Girlândia A Brasil, Andrews M do Nascimento, Ewelyne M de Lima, Suely G Figueiredo, Tadeu U de Andrade, Nazaré S Bissoli
Nandrolone Decanoate (ND) is an Anabolic Androgenic Steroid (AAS) that under abusive regimen can lead to multiple physiological adverse effects. Studies of AAS-mediated cardiovascular (CV) alterations were mostly taken from male subjects, even though women are also susceptible to the effects of AAS and gender-specific differences in susceptibility to vascular diseases exist. Here we investigate ND-induced vascular reactivity alterations in both sedentary and exercised female rats and whether these alterations depend on endothelium-derived factors...
April 2017: Steroids
https://www.readbyqxmd.com/read/28144902/ameliorative-effects-of-endurance-exercise-with-two-different-intensities-on-nandrolone-decanoate-induced-neurodegeneration-in-rats-involving-redox-and-apoptotic-systems
#17
Siyavash Joukar, Reza Vahidi, Alireza Farsinejad, Majid Asadi-Shekaari, Beydolah Shahouzehi
Despite the importance of this issue, less has been paid to the influence of exercise on the neural side effects of anabolic androgenic steroids and mechanisms. We investigated the effects of two levels of endurance exercise on neurodegeneration side effects of nandrolone. The study period was 8 weeks. Wistar rats were divided into nine groups including the control (CTL) group, mild exercise (mEx) group, and vehicle (Arach) group which received arachis oil intramuscularly, nandrolone (Nan) group which received nandrolone decanoate 5 mg/kg two times weekly, mEx+Arach group which treated with arachis oil along with mild exercise, mEx+Nan group which treated with nandrolone along with mild exercise, severe exercise (sEx) group, sEx+Arach, and sEx+Nan groups...
January 31, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28048973/effect-of-physical-exercise-and-anabolic-steroid-treatment-on-spinal-motoneurons-and-surrounding-glia-of-wild-type-and-als-mice
#18
Roman M Kassa, Roberta Bonafede, Federico Boschi, Marina Bentivoglio, Raffaella Mariotti
Motoneuron degeneration is the hallmark of amyotrophic lateral sclerosis (ALS). The cause and predisposing factors for sporadic ALS are still unknown. Exposure to a specific environmental risk factors in subjects with a susceptibility genotype may increase the risk of the disease. The role of physical activity and the use of anabolic steroids are still debated in epidemiological studies on patients and murine models of ALS. To assess at the cellular level the role (beneficial or detrimental) of physical exercise and the use of anabolic steroid, we here investigated, in SOD1(G93A) (mSOD1) mice and wild-type littermates, changes in the ventral horn after regular exercise, treatment with the anabolic androgenic steroid 19-nortestosterone (nandrolone), and their combination, compared with matched control sedentary mice...
February 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28019124/immediate-and-residual-effects-of-low-dose-nandrolone-decanoate-and-treadmill-training-on-adipose-and-reproductive-tissues-of-male-wistar-rats
#19
Josilene M Rodrigues, Vinicius P P Oliveira, Julia P Furlan, Ana Claudia Munhoz, Marcelo R S Rempel, Marcia N Brito, Nilton A Brito, Maria M D Pedrosa, Cecília E M Costa
CONTEXT: Residual effects after nandrolone decanoate (ND) treatment are not reported. OBJECTIVE: Immediate and residual effects of low-dose ND and treadmill training were investigated. MATERIALS AND METHODS: Male rats were trained and/or ND-treated for four weeks and the assessments were made after this period or four weeks later. RESULTS: The groups did not differ in final plasma glucose or AUC of the ivGTT, but hyperinsulinemia was noticed in some trained/treated groups...
May 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27989828/where-does-hydrolysis-of-nandrolone-decanoate-occur-in-the-human-body-after-release-from-an-oil-depot
#20
R W Kalicharan, M R Bout, C Oussoren, H Vromans
Long-term therapy of nandrolone (N) is recommended to increase mineral density and muscle strength. Using a parenteral sustained release drug formulation with nandrolone decanoate (ND), therapeutic N levels can be achieved and maintained. Until now, it is unknown if hydrolysis of ND into N occurs in tissue at the injection site or after systemic absorption. Therefore, hydrolysis studies were conducted to investigate the location and rate of ND hydrolysis after its release from the oil depot. ND hydrolysis was studied in porcine tissues, to mimic the human muscular and subcutaneous tissues...
December 30, 2016: International Journal of Pharmaceutics
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