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Dicky Struik, Paola Fadda, Tamara Zara, Erica Zamberletti, Tiziana Rubino, Daniela Parolaro, Walter Fratta, Liana Fattore
Clinical and pre-clinical observations indicate that anabolic-androgenic steroids can induce neurobiological changes that alter the rewarding effects of drugs of abuse. In this study, we investigated the effect of the anabolic steroid nandrolone on the rewarding properties of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) in rats. Lister Hooded male rats were treated intramuscularly with nandrolone (15mg/kg) or vehicle for 14 consecutive days, and then allowed to self-administer WIN (12.5μg/kg/infusion) intravenously...
November 24, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Parmita Chowdhury, Rita Mahanta
BACKGROUND: This article is a study of adverse effects associated with the abuse of recreational drugs such as Anabolic Androgenic Steroids. Nandrolone Decanoate is one such drug often abused by athletes and bodybuilders seeking enhanced physical strength or appearance. The use of such steroids has increased dramatically over the years. OBJECTIVE: The present study was conducted to investigate the impact of nandrolone decanoate when consumed at an abused dose, upon serum aldosterone concentration in albino mice...
November 21, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Luca Maria Chiesa, Maria Nobile, Sara Panseri, Bartolomeo Biolatti, Francesca Tiziana Cannizzo, Radmila Pavlovic, Francesco Arioli
Veterinary drugs usually have rapid clearance rates in the liver and kidney, hampering their detection in conventional matrices such as the liver or urine. Pharmacological principles such as esterification may be applied to facilitate the administration of veterinary drugs and increase drug half-life. Prednisolone, whose therapeutic administration is regulated for food producing animals in the EU, is available in its acetate form as well as nandrolone, a banned anabolic steroid, which may be obtained as nandrolone phenylpropionate and estradiol as a benzoyl ester...
November 15, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Asghar Tofighi, Minoo Shirpoor, M H Khadem Ansari, Alireza Shirpoor, Mitra Zerehpoosh
OBJECTIVE: Chronic anabolic androgenic steroid (AAS) consumption increases incidence of cardiovascular abnormalities in athletes and mechanisms underlying those abnormalities continue to be investigated. This study examines whether nandrolone consumption induced cardiac and coronary artery wall abnormalities via oxidative stress. It was also designed to determine whether enforced swimming augmented possible cardiotoxic effects of nandrolone in rat heart. METHODS: Twenty-four male Wistar rats were divided into 3 groups: control, nandrolone, and nandrolone with enforced swimming...
October 12, 2016: Anatolian Journal of Cardiology
Vinícius Augusto Simão, Luiz Gustavo De Almeida Chuffa, Isabel Cristina Cherici Camargo
This study evaluated for the first time the effects of different doses of the anabolic steroid Nandrolone Decanoate (ND) on the expression of ovarian steroid receptors (AR, ER-α, ER-β) and related sex hormones after treatment and recovery periods in adult rats. The animals were injected subcutaneously with doses of ND (1.87, 3.75, 7.5 or 15 mg/kg b.w.) or mineral oil (control group) for 15 days, and the experimental groups were divided into three periods of evaluation: (a) ND treatment for 15 days; (b) ND treatment and recovery for a period of 30 days; and, (c) ND treatment and recovery for a period of 60 days...
August 25, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Christopher Wu, Jason R Kovac
There has recently been renewed interest in novel clinical applications of the anabolic-androgenic steroid (AAS) testosterone and its synthetic derivatives, particularly given with the rising popularity of testosterone supplementation therapy (TST) for the treatment of male hypogonadism. In this manuscript, we provide a brief review of the history of AAS and discuss clinical applications of two of the more well-known AAS: nandrolone and oxandrolone. Both agents exhibit favorable myotrophic/androgenic ratios and have been investigated for effectiveness in numerous disease states...
October 2016: Current Urology Reports
Martin Flück, Severin Ruoss, Christoph B Möhl, Paola Valdivieso, Mario C Benn, Brigitte von Rechenberg, Endre Laczko, Junmin Hu, Karl Wieser, Dominik C Meyer, Christian Gerber
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon release and myotendinous retraction cause alterations in lipid related gene expression leading to fatty muscle infiltration, which can be suppressed by nandrolone through its genomic actions if applied immediately after tendon release...
January 2017: Journal of Steroid Biochemistry and Molecular Biology
L Chiesa, S Panseri, F T Cannizzo, B Biolatti, S Divari, R Benevelli, F Arioli, R Pavlovic
Under European legislation, the use of growth promoters is forbidden in food-producing livestock. The application of unofficial protocols with diverse combinations of veterinary drugs, administered in very low concentrations, hinders reliable detection and subsequent operative prevention. It was observed that nandrolone (anabolic steroid) and ractopamine (β-adrenergic agonist) are occasionally administered to animals, but little is known about their synergic action when they are administered together. Two specific analytical methods based on liquid chromatography-tandem mass spectrometry have been developed, both of which include hydrolysis of the corresponding conjugates...
July 22, 2016: Drug Testing and Analysis
Michal Jurášek, Sandra Göselová, Petra Mikšátková, Barbora Holubová, Eva Vyšatová, Martin Kuchař, Ladislav Fukal, Oldřich Lapčík, Pavel Drašar
Avidin-biotin technology was used for the implementation of an enzyme-linked immunosorbent assay (AB-ELISA) as a sensitive method for the detection of anabolic androgenic steroids (AAS) present in dietary supplements. Using click chemistry, novel haptens (linker-optimized biotinylated nandrolone (NT) and testosterone (T) at positions C-3 and C-17, respectively) were designed and synthesized to be then applied as four different immobilized competitors in a proposed set of four indirect competitive AB-ELISAs...
July 1, 2016: Drug Testing and Analysis
Christina Tsitsimpikou, Fotini Vasilaki, Konstantinos Tsarouhas, Persefoni Fragkiadaki, Maria Tzardi, Nikolaos Goutzourelas, Charitini Nepka, Alexandra Kalogeraki, Ioannis Heretis, Zoi Epitropaki, Dimitrios Kouretas, Aristidis M Tsatsakis
Among the various side effects of supra-physiological dose of anabolic androgenic steroids that are described, renal toxicity remains the least evaluated. The present study provides evidence that long-term administration of nandrolone decanoate could lead to alterations of renal function and structure in the experimental rabbit model. A pronounced increase in serum urea, creatinine, SGOT and SGPT is observed in the treated animals, with intramuscular administration being more detrimental. Histopathological evaluation of kidneys indicated hyperaemia, fibrosis and focal inflammation...
September 30, 2016: Toxicology Letters
Tamara R Nikolic, Vladimir I Zivkovic, Ivan M Srejovic, Dragan S Radovanovic, Nevena S Jeremic, Maja D Jevdjevic, Dragan M Djuric, Vladimir Lj Jakovljevic
Despite worldwide use of anabolic steroids in last decades, there is still contradictory information about their acute influence on myocardium. The aim of this study was to examine the acute effects of nandrolone decanoate (ND) on cardiodynamics and coronary flow in isolated rat heart. The hearts of male Wistar albino rats (n = 48, 12 per group, age 8 weeks, body mass 180-200 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH2O)...
March 21, 2016: Canadian Journal of Physiology and Pharmacology
Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, Lok-Hi Chow
LVV-hemorphin 7 (LVVYPWTQRF; LVV-H7), an N-terminal fragment of the β-chain of hemoglobin cleaved by cathepsin D/pepsin, is an atypical endogenous opioid peptide that is found in high concentration in blood. LVV-H7 acts as a μ-opioid agonist and an inhibitor of insulin-regulated aminopeptidase. Subchronic administration of anabolic androgenic steroids (AAS) has been clinically proven to induce the synthesis of erythrocytes and increase hemoglobin concentrations. Patients with a history of AAS abuse are more susceptible to opioid abuse...
May 26, 2016: Neuropeptides
A E Roşca, I Stoian, C Badiu, L Gaman, B O Popescu, L Iosif, R Mirica, I C Tivig, C S Stancu, C Căruntu, S E Voiculescu, L Zăgrean
Supraphysiological administration of anabolic androgenic steroids has been linked to increased blood pressure. The widely distributed amino acid taurine seems to be an effective depressor agent in drug-induced hypertension. The purpose of this study was to assess the impact of chronic high dose administration of nandrolone decanoate (DECA) and taurine on blood pressure in rats and to verify the potentially involved mechanisms. The study was conducted in 4 groups of 8 adult male Wistar rats, aged 14 weeks, treated for 12 weeks with: DECA (A group); vehicle (C group); taurine (T group), or with both drugs (AT group)...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Yufei Zhu, Shuyu Xie, Dongmei Chen, Yuanhu Pan, Wei Qu, Xu Wang, Zhenli Liu, Dapeng Peng, Lingli Huang, Yanfei Tao, Zonghui Yuan
A comprehensive strategy combining a quantitative method was developed for 30 banned drugs including β-agonists, hormones, glucocorticoid and psychiatric drugs in swine and chicken feeds. This rapid, simple and effective extraction method was based on matrix solid-phase dispersion and electrospray ionization tandem mass spectrometry. The quantitative method was validated after previous statistical optimization of the main parameters of matrix solid-phase dispersion. The limit of quantification of dopamine hydrochloride, chlormadinone acetate, melengestrol acetate, testosterone propionate, nandrolone and midazolam was 2 μg/kg and that of the other 24 drugs was 1 μg/kg...
July 2016: Journal of Separation Science
Rahil Jannatifar, Saeed Shokri, Ahmad Farrokhi, Reza Nejatbakhsh
BACKGROUND: Most studies on anabolic-androgenic steroids abuse have been done in adult rats, but few data are available to immature. OBJECTIVE: This study was conducted to assay the effect of Nandrolone Decanoate (ND) on the testis and testosterone concentration in male immature rats compare with mature ones in short and long time. MATERIALS AND METHODS: 40 mature rats were divided into 4 groups: group A (short term) and group B (long-term) received 10 mg/kg/day ND interaperitoneally for 35 and 70 days, respectively...
December 2015: International Journal of Reproductive Biomedicine (Yazd, Iran)
Michael M Pan, Jason R Kovac
Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health...
April 2016: Translational Andrology and Urology
Andrews Marques do Nascimento, Ewelyne Miranda de Lima, Girlandia Alexandre Brasil, Izabela Facco Caliman, Josiane Fernandes da Silva, Virgínia Soares Lemos, Tadeu Uggere de Andrade, Nazaré Souza Bissoli
UNLABELLED: Anabolic-androgenic steroids are misused, including by women, but little is known about the cardiovascular effects of these drugs on women. AIM: To evaluated the effects of nandrolone decanoate (ND) and resistive physical exercise on cardiac contractility in young female rats. MAIN METHODS: Female Wistar rats were separated into 4 groups: C (untrained animals); E (animals were submitted to resistance exercise by jumping in water 5 times per week); ND (animals were treated with ND, 20mg/kg/week for 4weeks); and NDE (trained and treated)...
June 15, 2016: Toxicology and Applied Pharmacology
Raween Kalicharan, Mohsin El Amrani, Peter Schot, Herman Vromans
Pharmaceutical oil depots are meant to release active substances at a sustained rate. Most of these depots contain benzyl alcohol (BOH) to facilitate the production and administration. Because BOH changes the solubility of components in both the body fluid and the oil formulation, it is relevant to know the change in the BOH concentration in the oil over time. In this study, volunteers were subcutaneously injected with an oil depot that contained 10% BOH, nandrolone decanoate, and cholecalciferol. The aim of this study was to determine the pharmacokinetic profiles of BOH and its metabolites benzoic acid and hippuric acid simultaneously in serum to estimate the BOH release out of the depot...
April 2016: Journal of Pharmaceutical Sciences
F C Gomes, L G A Chuffa, W R Scarano, P F F Pinheiro, W J Fávaro, R F Domeniconi
Age is a key factor in the development of prostatic lesions. An increase in reactive oxygen species levels occurs during aging. Furthermore, the indiscriminate use of anabolic androgenic steroids and physical exercise alter the availability of hormones and may promote the appearance of lesions. This study examined whether the use of nandrolone decanoate (ND), associated or not with resistance exercise training, affects the pathways related to the inflammatory response in the ventral prostate of adult and aged rats...
May 2016: Andrology
Gholamreza Bayat, Mohammad Javan, Fatemeh Safari, Azadeh Khalili, Saeed Shokri, Mahdi Goudarzvand, Mehdi Salimi, Sohrab Hajizadeh
ATP-sensitive potassium channels are supposed to have a substantial role in improvement of cardiac performance. This study was performed to evaluate whether nandrolone decanoate (ND) and (or) exercise training could affect the expression of cardiac K(ATP) channel subunits. Thirty-five male albino Wistar rats were randomly divided into 5 groups, including sedentary control (SC), sedentary vehicle (SV), sedentary ND (SND), exercise control (EC), and exercise and ND (E+ND). Exercise training was performed on a treadmill 5 times per week...
March 2016: Canadian Journal of Physiology and Pharmacology
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