Catherine Si, Kourtney Nickerson, Taylor Simmons, Parker Denton, M Russell Nichols, Robert C Dysko, Mark Hoenerhoff, Rinosh Mani, Cheryl Woods, Kenneth S Henderson, Zachary T Freeman
NOD.Cg- Prkdcscid Il2rgtm1Wjl /SzJ (NSG) mice, lacking many components of a mature immune system, are at increased risk of disease. General understanding of potential pathogens of these mice is limited. We describe a high mortality disease outbreak caused by an opportunistic bacterial infection in NSG mice. Affected animals exhibited perianal fecal staining, dehydration, and wasting. Histopathologic lesions included a primary necrotizing enterocolitis, with inflammatory and necrotizing lesions also occurring in the liver, kidneys, heart, and brain of some mice...
March 13, 2024: Toxicologic Pathology