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https://www.readbyqxmd.com/read/28076372/bad-to-the-bone-on-in-vitro-and-ex-vivo-microbial-biofilm-ability-to-directly-destroy-colonized-bone-surfaces-without-participation-of-host-immunity-or-osteoclastogenesis
#1
Adam Junka, Patrycja Szymczyk, Grzegorz Ziółkowski, Ewa Karuga-Kuzniewska, Danuta Smutnicka, Iwona Bil-Lula, Marzenna Bartoszewicz, Susan Mahabady, Parish Paymon Sedghizadeh
Bone infections are a significant public health burden associated with morbidity and mortality in patients. Microbial biofilm pathogens are the causative agents in chronic osteomyelitis. Research on the pathogenesis of osteomyelitis has focused on indirect bone destruction by host immune cells and cytokines secondary to microbial insult. Direct bone resorption by biofilm pathogens has not yet been seriously considered. In this study, common osteomyelitis pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Streptococcus mutans) were grown as biofilms in multiple in vitro and ex vivo experiments to analyze quantitative and qualitative aspects of bone destruction during infection...
2017: PloS One
https://www.readbyqxmd.com/read/28074591/variations-in-crestal-cortical-bone-thickness-at-dental-implant-sites-in-different-regions-of-the-jawbone
#2
Yi-Chun Ko, Heng-Li Huang, Yen-Wen Shen, Jyun-Yi Cai, Lih-Jyh Fuh, Jui-Ting Hsu
BACKGROUND: Dental implants have become reliable and predictable tools for treating missing teeth. The survival rate of dental implants is markedly influenced by the host bone quality and quantity of the jawbone. A better host bone provides higher initial stability of the dental implant, resulting in better osseointegration and a higher success rate. Host bone quality and quantity are determined by the crestal cortical bone thickness and inner cancellous bone density. OBJECTIVE: The purpose of this study was to determine the crestal cortical bone thickness at dental implant sites in different regions of the jawbone through the use of dental cone-beam computed tomographic (CBCT) images...
January 10, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28053317/jawbone-microenvironment-promotes-periodontium-regeneration-by-regulating-the-function-of-periodontal-ligament-stem-cells
#3
Bin Zhu, Wenjia Liu, Yihan Liu, Xicong Zhao, Hao Zhang, Zhuojing Luo, Yan Jin
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052867/how-consumer-physical-activity-monitors-could-transform-human-physiology-research
#4
Stephen P Wright, Tyish S Hall Brown, Scott R Collier, Kathryn Sandberg
Sedentary lifestyle and lack of physical activity are well-established risk factors for chronic disease and adverse health outcomes. Thus there is enormous interest in measuring physical activity in biomedical research. Many consumer physical activity monitors, including Basis® Health Tracker, BodyMedia® Fit, DirectLife®, Fitbit® Flex, Fitbit One, Fitbit Zip, Garmin® Vivofit, Jawbone® UP, MisFit® Shine, Nike® FuelBand, Polar® Loop, Withings® Pulse O2, and others have accuracies similar to that of research-grade physical activity monitors for measuring steps...
January 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27919170/validation-of-the-fitbit-one-garmin-vivofit-and-jawbone-up-activity-tracker-in-estimation-of-energy-expenditure-during-treadmill-walking-and-running
#5
Kym Price, Stephen R Bird, Noel Lythgo, Isaac S Raj, Jason Y L Wong, Chris Lynch
OBJECTIVES: To determine the validity of energy expenditure estimation made by the Fitbit One, Garmin Vivofit and Jawbone UP activity trackers during treadmill walking and running. Determining validity of such trackers will inform the interpretation of the data they generate. DESIGN: Cross-sectional study. METHOD: Fourteen adults walked at 0.70, 1.25, 1.80 ms(-1) and ran at 2.22, 2.78, 3.33 ms(-1) on a treadmill wearing a Fitbit One, Garmin Vivofit and Jawbone UP...
December 5, 2016: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27912681/how-valid-are-wearable-physical-activity-trackers-for-measuring-steps
#6
Hyun-Sung An, Gregory C Jones, Seoung-Ki Kang, Gregory J Welk, Jung-Min Lee
Wearable activity trackers have become popular for tracking individual's daily physical activity, but little information is available to substantiate the validity of these devices in step counts. Thirty-five healthy individuals completed three conditions of activity tracker measurement: walking/jogging on a treadmill, walking over-ground on an indoor track, and a 24-hour free-living condition. Participants wore 10 activity trackers at the same time for both treadmill and over-ground protocol. Of these 10 activity trackers three were randomly given for 24-hour free-living condition...
December 2, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27891304/metastasis-to-the-oral-soft-tissues-a-review-of-412-cases
#7
REVIEW
Soussan Irani
The present review article analyzes the characteristics of metastases to the oral soft tissues from 1937 to 2015. An extensive literature search was performed. All variables such as age, gender, and primary and secondary tumor sites were analyzed. Metastases to the major salivary glands were not included in this review. In general, there were 412 metastatic lesions developed in the oral soft tissues. The male-to-female ratio was approximately 1.8:1. The mean age of the patients at diagnosis was 58. The lung was the most common primary site and the gingiva was the most common metastatic site...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27889558/the-periosteal-microcirculation-in-health-and-disease-an-update-on-clinical-significance
#8
REVIEW
Andrea Szabó, Ágnes Janovszky, Levente Pócs, Mihály Boros
Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma-orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism...
November 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27881359/feasibility-and-effectiveness-of-using-wearable-activity-trackers-in-youth-a-systematic-review
#9
REVIEW
Nicola D Ridgers, Melitta A McNarry, Kelly A Mackintosh
BACKGROUND: The proliferation and popularity of wearable activity trackers (eg, Fitbit, Jawbone, Misfit) may present an opportunity to integrate such technology into physical activity interventions. While several systematic reviews have reported intervention effects of using wearable activity trackers on adults' physical activity levels, none to date have focused specifically on children and adolescents. OBJECTIVE: The aim of this review was to examine the effectiveness of wearable activity trackers as a tool for increasing children's and adolescents' physical activity levels...
November 23, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27867499/lessons-on-skeletal-cell-plasticity-from-studying-jawbone-regeneration-in-zebrafish
#10
REVIEW
Sandeep Paul, J Gage Crump
Three major mesenchymal cell types have important roles in determining the shapes of vertebrate animals: bone-producing osteoblasts, cartilage-producing chondrocytes, and fat-producing adipocytes. Although often considered discrete cell types, accumulating evidence is revealing mesenchymal cells of intermediate identities and interconversion of cell types. Such plasticity is particularly evident during adult skeletal repair. In this Review, we highlight recent work in zebrafish showing a role for hybrid cartilage-bone cells in large-scale regeneration of the adult jawbone, as well as their origins in the periosteum...
2016: BoneKEy Reports
https://www.readbyqxmd.com/read/27829771/large-radiopaque-lesion-in-the-posterior-mandible-a-challenging-case
#11
B Sasirekha, Philips Mathew, M Ganeshkumar, Ravi David Austin, Raj Prabhu
Radiopaque lesions of the jawbones are frequently encountered in dental radiographs. A variety of conditions such as chronic inflammation, soft tissue calcifications, fibrosseous lesions, odontogenic tumors, and bone neoplasms can manifest as radiopaque lesions on the jawbones. These radiopaque lesions are often difficult to distinguish from each other, hence making the formulation of differential diagnosis challenging. A thorough patient's history and clinical examination supplemented by appropriate investigations will enable the clinician in narrowing down the differential diagnosis and to identify the condition accurately...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27797795/cemento-ossifying-fibroma-of-mandible-mimicking-complex-composite-odontome
#12
Hitesh Sudarshan Dewan, Sudarshan Kumar Dewan, Sumit Bahl, Parth Tushar Parekh
Cemento-ossifying fibroma (COF) is a fibro-osseous lesion or non-odontogenic tumour that affects craniofacial bones. These lesions are included in the spectrum of fibro-osseous lesions arising from periodontal ligament cells, which can deposit combination of cementum and bone surrounded by fibrous tissue. It clinically, macroscopically and radiologically resembles complex composite odontome and can be differentiated only on the basis of histopathology. They usually occur solitarily as a painless and expansile spherical or ovoid jawbone mass that may displace the roots of adjacent teeth...
October 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27784318/dietary-phosphate-supplement-does-not-rescue-skeletal-phenotype-in-a-mouse-model-for-craniometaphyseal-dysplasia
#13
Yaling Liu, Eliane H Dutra, Ernst J Reichenberger, I-Ping Chen
BACKGROUND: Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. We previously reported a knock-in (KI) mouse model (Ank (KI/KI)) for CMD and showed transiently lower serum phosphate (Pi) as well as significantly higher mRNA levels of fibroblast growth factor 23 (Fgf23) in Ank (KI/KI) mice...
October 26, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27771829/a-retrospective-study-of-osteomyelitis-and-osteonecrosis-of-the-jaws-and-its-etiologic-implication-of-bisphosphonate-in-asians
#14
Sung Ok Hong, Chae-Yoon Lee, Junho Jung, Deog-Yoon Kim, Christian Walter, Yong-Dae Kwon
OBJECTIVE: The objective of this study were to find the annual case trend of inflammatory jawbone diseases and to investigate the impact of medication-related osteonecrosis of the jaws (MRONJ). MATERIAL AND METHODS: A retrospective study of 372 patients diagnosed with inflammatory jawbone condition except for alveolar osteitis from 2007 to 2015 was initiated. History taking and investigation of etiologic factors MRONJ, osteoradionecrosis (ORN), odontogenic infection, foreign body, and trauma were investigated...
October 22, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27686706/intraoral-radiographs-texture-analysis-for-dental-implant-planning
#15
Mayara B V Mundim, Danilo R Dias, Ronaldo M Costa, Cláudio R Leles, Paulo M Azevedo-Marques, Rejane F Ribeiro-Rotta
BACKGROUND AND OBJECTIVES: Computer vision extracts features or attributes from images improving diagnosis accuracy and aiding in clinical decisions. This study aims to investigate the feasibility of using texture analysis of periapical radiograph images as a tool for dental implant treatment planning. METHODS: Periapical radiograph images of 127 jawbone sites were obtained before and after implant placement. From the superimposition of the pre- and post-implant images, four regions of interest (ROI) were delineated on the pre-implant images for each implant site: mesial, distal and apical peri-implant areas and a central area...
November 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27632279/correlation-between-bone-density-and-instantaneous-torque-at-implant-site-preparation-a-validation-on-polyurethane-foam-blocks-of-a-device-assessing-density-of-jawbones
#16
Danilo Alessio Di Stefano, Paolo Arosio
PURPOSE: Bone density at implant placement sites is one of the key factors affecting implant primary stability, which is a determinant for implant osseointegration and rehabilitation success. Site-specific bone density assessment is, therefore, of paramount importance. Recently, an implant micromotor endowed with an instantaneous torque-measuring system has been introduced. The aim of this study was to assess the reliability of this system. MATERIALS AND METHODS: Five blocks with different densities (0...
September 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27608365/effect-of-dietary-calcium-deficiency-and-altered-diet-hardness-on-the-jawbone-growth-a-micro-ct-and-bone-histomorphometric-study-in-rats
#17
Yuko Fujita, Shota Goto, Maika Ichikawa, Ayako Hamaguchi, Kenshi Maki
OBJECTIVES: We examined the effects of a low-calcium diet and altered diet hardness on bone architecture and metabolism in the maxilla and mandible. MATERIALS AND METHODS: Male rats (n=48, 3 weeks old) were divided into six groups. In total, 24 rats were given a normal-calcium diet and the others were given a low-calcium diet. Each group was then divided into three subgroups, which were fed a 'hard̕ diet for 8 weeks, a 'soft̕ die for 8 weeks, or switched from the soft diet after 4 weeks to the hard diet for 4 weeks...
December 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27604226/estimating-physical-activity-and-sedentary-behavior-in-a-free-living-context-a-pragmatic-comparison-of-consumer-based-activity-trackers-and-actigraph-accelerometry
#18
Sjaan R Gomersall, Norman Ng, Nicola W Burton, Toby G Pavey, Nicholas D Gilson, Wendy J Brown
BACKGROUND: Activity trackers are increasingly popular with both consumers and researchers for monitoring activity and for promoting positive behavior change. However, there is a lack of research investigating the performance of these devices in free-living contexts, for which findings are likely to vary from studies conducted in well-controlled laboratory settings. OBJECTIVE: The aim was to compare Fitbit One and Jawbone UP estimates of steps, moderate-to-vigorous physical activity (MVPA), and sedentary behavior with data from the ActiGraph GT3X+ accelerometer in a free-living context...
September 7, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27585416/effect-of-injection-pressure-of-infiltration-anesthesia-to-the-jawbone
#19
Kenji Yoshida, Eri Tanaka, Hiroyoshi Kawaai, Shinya Yamazaki
To obtain effective infiltration anesthesia in the jawbone, high concentrations of local anesthetic are needed. However, to reduce pain experienced by patients during local anesthetic administration, low-pressure injection is recommended for subperiosteal infiltration anesthesia. Currently, there are no studies regarding the effect of injection pressure on infiltration anesthesia, and a standard injection pressure has not been clearly determined. Hence, the effect of injection pressure of subperiosteal infiltration anesthesia on local anesthetic infiltration to the jawbone was considered by directly measuring lidocaine concentration in the jawbone...
2016: Anesthesia Progress
https://www.readbyqxmd.com/read/27541832/a-novel-ano5-mutation-causing-gnathodiaphyseal-dysplasia-with-high-bone-turnover-osteosclerosis
#20
Tim Rolvien, Till Koehne, Uwe Kornak, Wolfgang Lehmann, Michael Amling, Thorsten Schinke, Ralf Oheim
Gnathodiaphyseal dysplasia (GDD) is a rare skeletal syndrome that involves an osteopetrosis-like sclerosis of the long bones and fibrous dysplasia-like cemento-osseous lesions of the jawbone. Although the genetic analysis of the respective patients has revealed mutations in the ANO5 gene as an underlying cause, there is still no established consensus regarding the bone status of GDD patients. We report a new case of GDD in a 13-year-old boy with recurrent diaphyseal fractures of the femur, in whom we identified a novel de novo missense mutation in the ANO5 gene, causing a p...
August 19, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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