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https://www.readbyqxmd.com/read/28229088/glutathione-induces-gaba-release-through-p2x7r-activation-on-m%C3%A3-ller-glia
#1
Hércules Rezende Freitas, Ricardo A de Melo Reis
The retinal tissue of warm-blooded vertebrates performs surprisingly complex and accurate transduction of visual information. To achieve precision, a multilayered neuroglia structure is established throughout the embryonic development, and the presence of radial Müller (glial) cells ensure differentiation, growth and survival for the neuronal elements within retinal environment. It is assumed that Müller cells serve as a dynamic reservoir of progenitors, capable of expressing transcription factors, differentiating and proliferating as either neuronal or glial cells depending on extrinsic cues...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28186464/evaluation-of-antimicrobial-photodynamic-therapy-using-indocyanine-green-and-near-infrared-diode-laser-against-enterococcus-faecalis-in-infected-human-root-canals
#2
Charis Beltes, Nikolaos Economides, Hercules Sakkas, Chrissanthy Papadopoulou, Theodoros Lambrianidis
OBJECTIVE: Photodynamic therapy (PDT) is considered a promising adjunct to the currently available endodontic disinfection techniques leading to more effective reduction of intracanal bacteria. The present ex vivo study aimed to assess the antimicrobial effect of PDT using indocyanine green (ICG) as photosensitizer and a near-infrared (NIR) diode laser in root canals of human teeth infected with Enterococcus faecalis. MATERIALS AND METHODS: Ninety single-rooted teeth after chemomechanical preparation and sterilization were contaminated with an E...
February 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28035106/zika-virus-infection-past-and-present-of-another-emerging-vector-borne-disease
#3
REVIEW
Hercules Sakkas, Vangelis Economou, Chrissanthy Papadopoulou
Zika virus infection is an emerging mosquito-borne disease, first identified in Uganda in 1947. It is caused by the Zika arbovirus, and transmitted by the bites of infected mosquitoes of the genus Aedes. For almost half a century, the Zika virus was reported as the causative agent of sporadic human infections. In 2007, the Zika virus emerged outside Asia and Africa causing an epidemic on the Island of Yap in Micronesia. The manifestation of the newly acquired human infection varies from asymptomatic to self-limiting acute febrile illness with symptoms and clinical features similar to those caused by the Dengue virus ('Dengue-like syndrome')...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28007855/complete-genome-sequences-of-four-bordetella-pertussis-vaccine-reference-strains-from-serum-institute-of-india
#4
Michael R Weigand, Yanhui Peng, Vladimir Loparev, Taccara Johnson, Phalasy Juieng, Sunil Gairola, Rakesh Kumar, Umesh Shaligram, Ramnath Gowrishankar, Hercules Moura, Jon Rees, David M Schieltz, Yulanda Williamson, Adrian Woolfitt, John Barr, M Lucia Tondella, Margaret M Williams
Serum Institute of India is among the world's largest vaccine producers. Here, we report the complete genome sequences for four Bordetella pertussis strains used by Serum Institute of India in the production of whole-cell pertussis vaccines.
December 22, 2016: Genome Announcements
https://www.readbyqxmd.com/read/28003119/secretomes-of-mycoplasma-hyopneumoniae-and-mycoplasma-flocculare-reveal-differences-associated-to-pathogenesis
#5
Jéssica A Paes, Karina R Lorenzatto, Sofia N de Moraes, Hercules Moura, John R Barr, Henrique B Ferreira
: Mycoplasma hyopneumoniae and Mycoplasma flocculare cohabit the porcine respiratory tract. However, M. hyopneumoniae causes the porcine enzootic pneumonia, while M. flocculare is a commensal bacterium. Comparative analyses demonstrated high similarity between these species, which includes the sharing of all predicted virulence factors. Nevertheless, studies related to soluble secretomes of mycoplasmas were little known, although they are important for bacterial-host interactions. The aim of this study was to perform a comparative analysis between the soluble secreted proteins repertoires of the pathogenic Mycoplasma hyopneumoniae and its closely related commensal Mycoplasma flocculare...
February 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27994215/antimicrobial-activity-of-basil-oregano-and-thyme-essential-oils
#6
REVIEW
Hercules Sakkas, Chrissanthy Papadopoulou
For centuries plants have been used for a wide variety of purposes, from treating infectious diseases to food preservation and perfume production. Presently, the increasing resistance of microorganisms to currently used antimicrobials in combination with the appearance of emerging diseases requires urgently the development of new, more effective drugs. Plants, due to the large biological and structural diversity of their components, constitute a unique and renewable source for the discovery of new antibacterial, antifungal and antiparasitic treatments...
December 20, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27989928/anti-botulism-single-shot-vaccine-using-chitosan-for-protein-encapsulation-by-simple-coacervation
#7
Roger S Sari, Anna Christina de Almeida, Alex S R Cangussu, Edson V Jorge, Otto D Mozzer, Hércules Otacílio Santos, Wagner Quintilio, Igor Viana Brandi, Viviane Aguiar Andrade, Angelo Samir M Miguel, Eliane M Sobrinho Santos
The aim of the present study was to compare the potency and safety of vaccines against Clostridium botulinum (C. botulinum) type C and D formulated with chitosan as controlled release matrix and vaccines formulated in conventional manner using aluminum hydroxide. Parameters were established for the development of chitosan microspheres, using simple coacervation to standardize the use of this polymer in protein encapsulation for vaccine formulation. To formulate a single shot vaccine inactivated antigens of C...
October 27, 2016: Anaerobe
https://www.readbyqxmd.com/read/27907172/neuroendocrine-inflammatory-responses-in-overweight-obese-infants
#8
Ana Cristina Resende Camargos, Vanessa Amaral Mendonça, Camila Alves de Andrade, Katherine Simone Caires Oliveira, Rosalina Tossige-Gomes, Etel Rocha-Vieira, Camila Danielle Cunha Neves, Érica Leandro Marciano Vieira, Hércules Ribeiro Leite, Murilo Xavier Oliveira, Antônio Lúcio Teixeira Júnior, Cândido Celso Coimbra, Ana Cristina Rodrigues Lacerda
Childhood obesity is related to a cascade of neuroendocrine inflammatory changes. However, there remains a gap in the current literature regarding the possible occurrence of these changes in overweight/obese infants. The objective of this study was to evaluate adipokines, cortisol, brain-derived neurotrophic factor (BDNF) and redox status in overweight/obese infants versus normal-weight peers. A cross-sectional study was conducted with 50 infants (25 in the overweight/obese group and 25 in the normal-weight group) between 6 and 24 months...
2016: PloS One
https://www.readbyqxmd.com/read/27852634/calibration-and-evaluation-of-quantitative-antibody-titers-for-measles-virus-by-using-the-bioplex-2200
#9
Todd F Hatchette, Heidi Scholz, Shelly Bolotin, Natasha S Crowcroft, Colleen Jackson, Elizabeth McLachlan, Alberto Severini
The BioPlex 2200 (Bio-Rad Laboratories, Hercules, CA) is a rapid, automated platform, which can screen large numbers of specimens for antibodies to measles, mumps, rubella, and varicella. Although approved for producing qualitative results, in this study we validated the test (off-label) to allow reporting of quantitative results. To do this, we used the third anti-measles World Health Organization standard to generate a calibration curve that allowed relative fluorescence intensity to be translated into quantitative antibody titer (antibody units [AU]/ml)...
January 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27830020/evaluation-of-a-research-use-only-luminex-based-assay-for-measurement-of-procalcitonin-in-serum-samples
#10
Charles Garrigan, Jennifer Han, Pam Tolomeo, Katherine J Johnson, Stephen R Master, Ebbing Lautenbach, Irving Nachamkin
Research use only (RUO) assays do not undergo a validation process similar to test kits used for clinical purposes. Several studies have suggested that RUO assays need to be validated prior to use in any research studies. We evaluated a research use only Luminex platform based assay for measuring serum procalcitonin levels (Bio-Plex Pro(TM) Human Acute Phase Multiplex Assay, Bio-Rad Laboratories, Hercules, CA) for comparability with an FDA cleared assay for procalcitonin (VIDAS B.R.A.H.M.S. PCT Assay, bioMérieux, Durham, NC)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27816623/antimicrobial-photodynamic-therapy-using-indocyanine-green-and-near-infrared-diode-laser-in-reducing-entrerococcus-faecalis
#11
Charis Beltes, Hercules Sakkas, Nikolaos Economides, Chrissanthy Papadopoulou
BACKGROUND: The use of Antimicrobial Photodynamic Therapy (aPDT) has been suggested as an adjuvant method to eliminate facultative bacteria during root canal disinfection. The purpose of this preliminary in vitro study was to determine whether the light-activated antimicrobial agent, Indocyanine green (ICG), could be used as photosensitizer and kill Enterococcus faecalis strain under planktonic conditions when irradiated with near-infared (NIR) diode laser emitting in 810nm wavelength...
November 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27814264/the-influence-of-ph-and-chemical-composition-of-beverages-on-color-stability-of-a-nanofilled-composite-resin
#12
Hercules Bezerra Dias, Emanuelle Teixeira Carrera, Alessandra Nara de Souza Rastelli
Due to increasing consumer knowledge about the health benefits associated with anthocyanin-rich foods and beverages-such as acai and blueberry juices-the growing consumption of these products should be a source of concern for dentists. Since anthocyanins are colorants that can discolor teeth and restorations, the aim of this study was to investigate the staining effects of 2 anthocyanin-rich beverages on a nanofilled composite resin. Specimens were prepared, separated into 3 groups, and immersed in either artificial saliva or 1 of the 2 staining solutions (blueberry or acai juice) at 37°C for 7 days...
November 2016: General Dentistry
https://www.readbyqxmd.com/read/27811659/redescription-and-phylogenetic-analysis-of-the-type-species-of-the-giant-pill-millipede-genus-sphaeropoeus-brandt-1833-diplopoda-sphaerotheriida-zephroniidae
#13
Thomas Wesener
Sphaeropoeus hercules Brandt, 1833, the type species of one of the oldest genus names in Sphaerotheriida, is redescribed for the first time based on its fragmented type specimen. While damaged, the specimen shows characters clearly different from other, diverse and similar genera of the family Zephroniidae, such as Zephronia Gray, 1832 and Castanotherium Pocock, 1895. S. hercules has a record number of >180 apical cones on the antennae, more than any other millipede. The species, together with another species of the genus Castanotherium, C...
November 2, 2016: Zootaxa
https://www.readbyqxmd.com/read/27776288/hyaluronic-acid-on-collagen-membranes-an-experimental-study-in-rats
#14
Edson Costa E Silva, Sheyla Viana Omonte, Alessandro Gomides Veiga Martins, Hércules Henrique Onibene de Castro, Hayder Egg Gomes, Élton Gonçalves Zenóbio, Peterson Antônio Dutra de Oliveira, Martinho Campolina Rebello Horta, Paulo Eduardo Alencar Souza
OBJECTIVE: The aim of this study was to evaluate the effect of hyaluronic acid (HA) in the structure and degradation patterns of BioGide(®) and OsseoGuard™ collagen membranes. HA mediates inflammation and acts in cell migration, adhesion, and differentiation, benefitting tissue remodeling and vascularization. These are desirable effects in guided regeneration procedures, but it is still unknown whether HA alters the barrier properties of absorbable membranes. DESIGN: Bone defects were created in the calvaria of rats, which were treated with HA gel 1% (HA group) or simply filled with blood clot (control group), and covered with BioGide(®) or OsseoGuard™...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27693249/exposure-of-cultured-fibroblasts-to-the-peptide-pr-11-for-the-identification-of-induced-proteome-alterations-and-discovery-of-novel-potential-ligands
#15
Gustavo Silveira Breguez, Leandro Xavier Neves, Karina Taciana Santos Silva, Lorran Miranda Andrade de Freitas, Gabriela de Oliveira Faria, Mauro César Isoldi, William Castro-Borges, Milton Hércules Guerra de Andrade
The PR-11 peptide corresponds to the N-terminal and active region of the endogenously synthesized PR-39 molecule, of porcine origin. It is known to possess various biological effects including antimicrobial properties, angiogenic and anti-inflammatory activities. Apart from its reported activity as a proteasome inhibitor, a more comprehensive understanding of its function, at the molecular level, is still lacking. In this study, we used a label-free shotgun strategy to evaluate the proteomic alterations caused by exposure of cultured fibroblasts to the peptide PR-11...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27688085/differentiation-and-prognostic-markers-in-ampullary-cancer-role-of-p53-mdm2-cdx2-mucins-and-cytokeratins
#16
Iraklis Perysinakis, Emilia Minaidou, Dimitrios Mantas, George C Sotiropoulos, Vasileia Leontara, Hercules Tsipras, George N Zografos, Ilias Margaris, Gregory Kouraklis
INTRODUCTION: Subclassification of ampullary adenocarcinomas into intestinal and pancreatobiliary type has prognostic and therapeutic implications. Immunohistochemical staining against specific biomarkers has been proven to be a useful adjunct in determining the exact histotype. Furthermore the immunohistochemical profile is suggestive of the molecular pathogenic mechanisms through which the tumor evolved. The aim of this study was to correlate p53, MDM2, CK7, CK20, MUC1, MUC2 and CDX2 expression in ampullary adenocarcinomas with the type of differentiation and patients' survival...
November 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27661063/parapatric-genetic-introgression-and-phenotypic-assimilation-testing-conditions-for-introgression-between-hercules-beetles-dynastes-dynastinae
#17
Jen-Pan Huang
The prevalence and consequences of genetic introgression between species have been intensively debated. I used Hercules beetles as examples to test for conditions that may be associated with the occurrence of introgression. RADseq data were used to reconstruct the species tree and history of introgression between Hercules beetles. Image data from museum specimens were used to investigate the phenotypic similarity of two adaptive traits between species from two distinct climatic realms (Nearctic vs. Neotropical)...
September 23, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27639320/long-term-clinical-outcomes-in-implantable-cardioverter-defibrillator-recipients-on-the-island-of-crete
#18
Emmanuel M Kanoupakis, John A Fanourgiakis, Hercules E Mavrakis, Eleutherios M Kallergis, Emmanuel N Simantirakis, Stavros I Crysostomakis, Ilias G Saloustros, Gregory I Chlouverakis, Panos E Vardas
PURPOSE: The aim of the current study is to disseminate long-term "real-world" data on mortality and device therapies in primary and secondary prevention implantable cardioverter defibrillator (ICD) recipients on the island of Crete. METHODS: We analyzed data for all consecutive patients who received an ICD in our tertiary university hospital from 1993 until December 2013. Follow-up visits were performed every 6 months or more frequently when indicated. Survival status was recorded, and all stored episodes during interrogation were registered and classified as appropriate or inappropriate...
August 20, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27621547/effect-of-potentially-chromogenic-beverages-on-shear-bond-strength-of-acrylic-denture-teeth-to-heat-polymerized-denture-base-resins
#19
Karin Hermana Neppelenbroek, Vanessa Migliorini Urban, Denise Gusmão de Oliveira, Vinícius Carvalho Porto, Hercules Jorge Almilhatti, Nara Hellen Campanha
BACKGROUND: Detachment of denture acrylic resin artificial teeth from denture base resin is one of the most common problems presented by denture wearers. PURPOSE: This study investigated the shear bond strength (SBS) and fracture type of bonding interface of two commercial acrylic teeth (Vipi Dent Plus e Biolux) to two denture base resins (Vipi Cril e Lucitone 550) after immersion in potentially chromogenic beverages (coffee, cola soft drink, and red wine) or control solution (distilled water)...
July 2016: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/27618432/prevalence-and-risks-of-syphilis-among-commercial-sex-workers-in-georgetown-guyana
#20
R Kurup, A C Hercules
Objective: To determine the key affected populations (KAP) and prevalence of syphilis and to investigate the sexual health practices and constrains involved among commercial sex workers (CSWs) in Guyana. Methods: The participants were randomly selected from CSWs participating in support group meetings held in Georgetown and Berbice. The survey was cross-sectional and SPSS was used to perform the data analysis. Results: The majority (92.9%) of CSW were tested negative for syphilis while two (2...
June 4, 2015: West Indian Medical Journal
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