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https://www.readbyqxmd.com/read/28333150/kaiso-depletion-attenuates-the-growth-and-survival-of-triple-negative-breast-cancer-cells
#1
Blessing I Bassey-Archibong, Lyndsay G A Rayner, Shawn M Hercules, Craig W Aarts, Anna Dvorkin-Gheva, Jonathan L Bramson, John A Hassell, Juliet M Daniel
Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of Kaiso in the growth and survival of TNBCs. Herein, we report that Kaiso depletion attenuates TNBC cell proliferation, and delays tumor onset in mice xenografted with the aggressive MDA-231 breast tumor cells...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28271628/zinc-oxide-3d-microstructures-as-an-antimicrobial-filler-content-for-composite-resins
#2
Hércules Bezerra Dias, Maria Inês Basso Bernardi, Matheus Aparecido Dos Santos Ramos, Tamara Carolina Trevisan, Taís Maria Bauab, Antônio Carlos Hernandes, Alessandra Nara de Souza Rastelli
The aim of this study was to evaluate the antibacterial activity of a composite resin modified by 3D zinc oxide (ZnO) microstructures and to verify possible alterations on its mechanical properties. ZnO was synthesized by hydrothermal approach and characterized by X-ray diffraction (XRD), surface area by Brunauer, Emmett and Teller (BET), Fourier transform infrared spectroscopy (FTIR) and Field emission scanning electron microscopy (FESEM). The minimum inhibitory concentrations of ZnO against Streptococcus mutans, Escherichia coli, Staphylococcus aureus, and Candida albicans were determinated...
March 8, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28262797/low-crystalline-iron-oxide-hydroxide-nanoparticle-anode-for-high-performance-supercapacitors
#3
Kwadwo Asare Owusu, Longbing Qu, Jiantao Li, Zhaoyang Wang, Kangning Zhao, Chao Yang, Kalele Mulonda Hercule, Chao Lin, Changwei Shi, Qiulong Wei, Liang Zhou, Liqiang Mai
Carbon materials are generally preferred as anodes in supercapacitors; however, their low capacitance limits the attained energy density of supercapacitor devices with aqueous electrolytes. Here, we report a low-crystalline iron oxide hydroxide nanoparticle anode with comprehensive electrochemical performance at a wide potential window. The iron oxide hydroxide nanoparticles present capacitances of 1,066 and 716 F g(-1) at mass loadings of 1.6 and 9.1 mg cm(-2), respectively, a rate capability with 74...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28239823/inhibitory-effect-and-mechanism-of-metformin-on-human-ovarian-cancer-cells-skov-3-and-a2780
#4
J Huo, X-H Bian, Y Huang, Z-C Miao, L-H Song
OBJECTIVE: Ovarian cancer is the most common malignant tumor in female reproductive system. Metformin is an orally taken hypoglycemic agent, which is extensively applied in the clinic. Clinical trials find that there may be a certain degree of action of the metformin in inhibiting malignant tumors. This paper aims to investigate the inhibitory effect and mechanism of metformin on human ovarian cancer cells. MATERIALS AND METHODS: Through in vitro cell experiment, the influences of metformin on the proliferation, colony formation and apoptosis of ovarian carcinoma cells were studied...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28238825/association-between-obesity-related-biomarkers-and-cognitive-and-motor-development-in-infants
#5
Ana Cristina R Camargos, Vanessa A Mendonça, Katherine S C Oliveira, Camila Alves de Andrade, Hércules Ribeiro Leite, Sueli Ferreira da Fonseca, Erica Leandro Marciano Vieira, Antônio Lúcio Teixeira Júnior, Ana Cristina Rodrigues Lacerda
BACKGROUND: This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. METHODS: A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development...
February 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28229088/glutathione-induces-gaba-release-through-p2x7r-activation-on-m%C3%A3-ller-glia
#6
Hércules Rezende Freitas, Ricardo A de Melo Reis
The retinal tissue of warm-blooded vertebrates performs surprisingly complex and accurate transduction of visual information. To achieve precision, a multilayered neuroglia structure is established throughout the embryonic development, and the presence of radial Müller (glial) cells ensure differentiation, growth and survival for the neuronal elements within retinal environment. It is assumed that Müller cells serve as a dynamic reservoir of progenitors, capable of expressing transcription factors, differentiating and proliferating as either neuronal or glial cells depending on extrinsic cues...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28186464/evaluation-of-antimicrobial-photodynamic-therapy-using-indocyanine-green-and-near-infrared-diode-laser-against-enterococcus-faecalis-in-infected-human-root-canals
#7
Charis Beltes, Nikolaos Economides, Hercules Sakkas, Chrissanthy Papadopoulou, Theodoros Lambrianidis
OBJECTIVE: Photodynamic therapy (PDT) is considered a promising adjunct to the currently available endodontic disinfection techniques leading to more effective reduction of intracanal bacteria. The present ex vivo study aimed to assess the antimicrobial effect of PDT using indocyanine green (ICG) as photosensitizer and a near-infrared (NIR) diode laser in root canals of human teeth infected with Enterococcus faecalis. MATERIALS AND METHODS: Ninety single-rooted teeth after chemomechanical preparation and sterilization were contaminated with an E...
February 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28035106/zika-virus-infection-past-and-present-of-another-emerging-vector-borne-disease
#8
REVIEW
Hercules Sakkas, Vangelis Economou, Chrissanthy Papadopoulou
Zika virus infection is an emerging mosquito-borne disease, first identified in Uganda in 1947. It is caused by the Zika arbovirus, and transmitted by the bites of infected mosquitoes of the genus Aedes. For almost half a century, the Zika virus was reported as the causative agent of sporadic human infections. In 2007, the Zika virus emerged outside Asia and Africa causing an epidemic on the Island of Yap in Micronesia. The manifestation of the newly acquired human infection varies from asymptomatic to self-limiting acute febrile illness with symptoms and clinical features similar to those caused by the Dengue virus ('Dengue-like syndrome')...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28007855/complete-genome-sequences-of-four-bordetella-pertussis-vaccine-reference-strains-from-serum-institute-of-india
#9
Michael R Weigand, Yanhui Peng, Vladimir Loparev, Taccara Johnson, Phalasy Juieng, Sunil Gairola, Rakesh Kumar, Umesh Shaligram, Ramnath Gowrishankar, Hercules Moura, Jon Rees, David M Schieltz, Yulanda Williamson, Adrian Woolfitt, John Barr, M Lucia Tondella, Margaret M Williams
Serum Institute of India is among the world's largest vaccine producers. Here, we report the complete genome sequences for four Bordetella pertussis strains used by Serum Institute of India in the production of whole-cell pertussis vaccines.
December 22, 2016: Genome Announcements
https://www.readbyqxmd.com/read/28003119/secretomes-of-mycoplasma-hyopneumoniae-and-mycoplasma-flocculare-reveal-differences-associated-to-pathogenesis
#10
Jéssica A Paes, Karina R Lorenzatto, Sofia N de Moraes, Hercules Moura, John R Barr, Henrique B Ferreira
Mycoplasma hyopneumoniae and Mycoplasma flocculare cohabit the porcine respiratory tract. However, M. hyopneumoniae causes the porcine enzootic pneumonia, while M. flocculare is a commensal bacterium. Comparative analyses demonstrated high similarity between these species, which includes the sharing of all predicted virulence factors. Nevertheless, studies related to soluble secretomes of mycoplasmas were little known, although they are important for bacterial-host interactions. The aim of this study was to perform a comparative analysis between the soluble secreted proteins repertoires of the pathogenic Mycoplasma hyopneumoniae and its closely related commensal Mycoplasma flocculare...
February 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27994215/antimicrobial-activity-of-basil-oregano-and-thyme-essential-oils
#11
REVIEW
Hercules Sakkas, Chrissanthy Papadopoulou
For centuries plants have been used for a wide variety of purposes, from treating infectious diseases to food preservation and perfume production. Presently, the increasing resistance of microorganisms to currently used antimicrobials in combination with the appearance of emerging diseases requires urgently the development of new, more effective drugs. Plants, due to the large biological and structural diversity of their components, constitute a unique and renewable source for the discovery of new antibacterial, antifungal and antiparasitic treatments...
December 20, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27989928/anti-botulism-single-shot-vaccine-using-chitosan-for-protein-encapsulation-by-simple-coacervation
#12
Roger S Sari, Anna Christina de Almeida, Alex S R Cangussu, Edson V Jorge, Otto D Mozzer, Hércules Otacílio Santos, Wagner Quintilio, Igor Viana Brandi, Viviane Aguiar Andrade, Angelo Samir M Miguel, Eliane M Sobrinho Santos
The aim of the present study was to compare the potency and safety of vaccines against Clostridium botulinum (C. botulinum) type C and D formulated with chitosan as controlled release matrix and vaccines formulated in conventional manner using aluminum hydroxide. Parameters were established for the development of chitosan microspheres, using simple coacervation to standardize the use of this polymer in protein encapsulation for vaccine formulation. To formulate a single shot vaccine inactivated antigens of C...
October 27, 2016: Anaerobe
https://www.readbyqxmd.com/read/27907172/neuroendocrine-inflammatory-responses-in-overweight-obese-infants
#13
Ana Cristina Resende Camargos, Vanessa Amaral Mendonça, Camila Alves de Andrade, Katherine Simone Caires Oliveira, Rosalina Tossige-Gomes, Etel Rocha-Vieira, Camila Danielle Cunha Neves, Érica Leandro Marciano Vieira, Hércules Ribeiro Leite, Murilo Xavier Oliveira, Antônio Lúcio Teixeira Júnior, Cândido Celso Coimbra, Ana Cristina Rodrigues Lacerda
Childhood obesity is related to a cascade of neuroendocrine inflammatory changes. However, there remains a gap in the current literature regarding the possible occurrence of these changes in overweight/obese infants. The objective of this study was to evaluate adipokines, cortisol, brain-derived neurotrophic factor (BDNF) and redox status in overweight/obese infants versus normal-weight peers. A cross-sectional study was conducted with 50 infants (25 in the overweight/obese group and 25 in the normal-weight group) between 6 and 24 months...
2016: PloS One
https://www.readbyqxmd.com/read/27852634/calibration-and-evaluation-of-quantitative-antibody-titers-for-measles-virus-by-using-the-bioplex-2200
#14
Todd F Hatchette, Heidi Scholz, Shelly Bolotin, Natasha S Crowcroft, Colleen Jackson, Elizabeth McLachlan, Alberto Severini
The BioPlex 2200 (Bio-Rad Laboratories, Hercules, CA) is a rapid, automated platform, which can screen large numbers of specimens for antibodies to measles, mumps, rubella, and varicella. Although approved for producing qualitative results, in this study we validated the test (off-label) to allow reporting of quantitative results. To do this, we used the third anti-measles World Health Organization standard to generate a calibration curve that allowed relative fluorescence intensity to be translated into quantitative antibody titer (antibody units [AU]/ml)...
January 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27830020/evaluation-of-a-research-use-only-luminex-based-assay-for-measurement-of-procalcitonin-in-serum-samples
#15
Charles Garrigan, Jennifer Han, Pam Tolomeo, Katherine J Johnson, Stephen R Master, Ebbing Lautenbach, Irving Nachamkin
Research use only (RUO) assays do not undergo a validation process similar to test kits used for clinical purposes. Several studies have suggested that RUO assays need to be validated prior to use in any research studies. We evaluated a research use only Luminex platform based assay for measuring serum procalcitonin levels (Bio-Plex Pro(TM) Human Acute Phase Multiplex Assay, Bio-Rad Laboratories, Hercules, CA) for comparability with an FDA cleared assay for procalcitonin (VIDAS B.R.A.H.M.S. PCT Assay, bioMérieux, Durham, NC)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27816623/antimicrobial-photodynamic-therapy-using-indocyanine-green-and-near-infrared-diode-laser-in-reducing-entrerococcus-faecalis
#16
Charis Beltes, Hercules Sakkas, Nikolaos Economides, Chrissanthy Papadopoulou
BACKGROUND: The use of Antimicrobial Photodynamic Therapy (aPDT) has been suggested as an adjuvant method to eliminate facultative bacteria during root canal disinfection. The purpose of this preliminary in vitro study was to determine whether the light-activated antimicrobial agent, Indocyanine green (ICG), could be used as photosensitizer and kill Enterococcus faecalis strain under planktonic conditions when irradiated with near-infared (NIR) diode laser emitting in 810nm wavelength...
November 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27814264/the-influence-of-ph-and-chemical-composition-of-beverages-on-color-stability-of-a-nanofilled-composite-resin
#17
Hercules Bezerra Dias, Emanuelle Teixeira Carrera, Alessandra Nara de Souza Rastelli
Due to increasing consumer knowledge about the health benefits associated with anthocyanin-rich foods and beverages-such as acai and blueberry juices-the growing consumption of these products should be a source of concern for dentists. Since anthocyanins are colorants that can discolor teeth and restorations, the aim of this study was to investigate the staining effects of 2 anthocyanin-rich beverages on a nanofilled composite resin. Specimens were prepared, separated into 3 groups, and immersed in either artificial saliva or 1 of the 2 staining solutions (blueberry or acai juice) at 37°C for 7 days...
November 2016: General Dentistry
https://www.readbyqxmd.com/read/27811659/redescription-and-phylogenetic-analysis-of-the-type-species-of-the-giant-pill-millipede-genus-sphaeropoeus-brandt-1833-diplopoda-sphaerotheriida-zephroniidae
#18
Thomas Wesener
Sphaeropoeus hercules Brandt, 1833, the type species of one of the oldest genus names in Sphaerotheriida, is redescribed for the first time based on its fragmented type specimen. While damaged, the specimen shows characters clearly different from other, diverse and similar genera of the family Zephroniidae, such as Zephronia Gray, 1832 and Castanotherium Pocock, 1895. S. hercules has a record number of >180 apical cones on the antennae, more than any other millipede. The species, together with another species of the genus Castanotherium, C...
November 2, 2016: Zootaxa
https://www.readbyqxmd.com/read/27776288/hyaluronic-acid-on-collagen-membranes-an-experimental-study-in-rats
#19
Edson Costa E Silva, Sheyla Viana Omonte, Alessandro Gomides Veiga Martins, Hércules Henrique Onibene de Castro, Hayder Egg Gomes, Élton Gonçalves Zenóbio, Peterson Antônio Dutra de Oliveira, Martinho Campolina Rebello Horta, Paulo Eduardo Alencar Souza
OBJECTIVE: The aim of this study was to evaluate the effect of hyaluronic acid (HA) in the structure and degradation patterns of BioGide(®) and OsseoGuard™ collagen membranes. HA mediates inflammation and acts in cell migration, adhesion, and differentiation, benefitting tissue remodeling and vascularization. These are desirable effects in guided regeneration procedures, but it is still unknown whether HA alters the barrier properties of absorbable membranes. DESIGN: Bone defects were created in the calvaria of rats, which were treated with HA gel 1% (HA group) or simply filled with blood clot (control group), and covered with BioGide(®) or OsseoGuard™...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27693249/exposure-of-cultured-fibroblasts-to-the-peptide-pr-11-for-the-identification-of-induced-proteome-alterations-and-discovery-of-novel-potential-ligands
#20
Gustavo Silveira Breguez, Leandro Xavier Neves, Karina Taciana Santos Silva, Lorran Miranda Andrade de Freitas, Gabriela de Oliveira Faria, Mauro César Isoldi, William Castro-Borges, Milton Hércules Guerra de Andrade
The PR-11 peptide corresponds to the N-terminal and active region of the endogenously synthesized PR-39 molecule, of porcine origin. It is known to possess various biological effects including antimicrobial properties, angiogenic and anti-inflammatory activities. Apart from its reported activity as a proteasome inhibitor, a more comprehensive understanding of its function, at the molecular level, is still lacking. In this study, we used a label-free shotgun strategy to evaluate the proteomic alterations caused by exposure of cultured fibroblasts to the peptide PR-11...
December 2016: Biochimica et Biophysica Acta
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