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https://www.readbyqxmd.com/read/29694022/correction-to-adap-gc-3-0-improved-peak-detection-and-deconvolution-of-co-eluting-metabolites-from-gc-tof-ms-data-for-metabolomics-studies
#1
Yan Ni, Mingming Su, Yunping Qiu, Wei Jia, Xiuxia Du
No abstract text is available yet for this article.
April 25, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29548324/determinants-of-facilitated-health-insurance-enrollment-for-patients-with-hiv-disease-and-impact-of-insurance-enrollment-on-targeted-health-outcomes
#2
Renae Furl, Shinobu Watanabe-Galloway, Elizabeth Lyden, Susan Swindells
BACKGROUND: The introduction of the Affordable Care Act (ACA) has provided unprecedented opportunities for uninsured people with HIV infection to access health insurance, and to examine the impact of this change in access. AIDS Drug Assistance Programs (ADAPs) have been directed to pursue uninsured individuals to enroll in the ACA as both a cost-saving strategy and to increase patient access to care. We evaluated the impact of ADAP-facilitated health insurance enrollment on health outcomes, and demographic and clinical factors that influenced whether or not eligible patients enrolled...
March 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29501596/radioprotection-measures-during-the-learning-curve-with-hybrid-operating-rooms
#3
Liliana Fidalgo Domingos, Enrique M San Norberto García, Diana Gutiérrez Castillo, Cintia Flota Ruiz, Isabel Estévez Fernández, Carlos Vaquero Puerta
BACKGROUND: Endovascular procedures come with a potential risk of radiation hazards both to patients and to the vascular staff. Classically, most endovascular interventions took place in regular operating rooms (ORs) using a fluoroscopy C-arm unit controlled by a third party. Hybrid operating rooms (HORs) provide an optimal surgical suit with all the qualities of a fixed C-arm device, while allowing the device to be controlled by the surgical team. The latest studies suggest that an operator-controlled system may reduce the radiation dose...
March 6, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29497217/on-reciprocal-causation-in-the-evolutionary-process
#4
REVIEW
Erik I Svensson
Recent calls for a revision of standard evolutionary theory (SET) are based partly on arguments about the reciprocal causation. Reciprocal causation means that cause-effect relationships are bi-directional, as a cause could later become an effect and vice versa. Such dynamic cause-effect relationships raise questions about the distinction between proximate and ultimate causes, as originally formulated by Ernst Mayr. They have also motivated some biologists and philosophers to argue for an Extended Evolutionary Synthesis (EES)...
2018: Evolutionary Biology
https://www.readbyqxmd.com/read/29473051/ap4-deficiency-a-novel-form-of-neurodegeneration-with-brain-iron-accumulation
#5
Agathe Roubertie, Nelson Hieu, Charles-Joris Roux, Nicolas Leboucq, Gael Manes, Majida Charif, Bernard Echenne, Cyril Goizet, Claire Guissart, Pierre Meyer, Cecilia Marelli, François Rivier, Lydie Burglen, Rita Horvath, Christian P Hamel, Guy Lenaers
Objective: To describe the clinico-radiological phenotype of 3 patients harboring a homozygous novel AP4M1 pathogenic mutation. Methods: The 3 patients from an inbred family who exhibited early-onset developmental delay, tetraparesis, juvenile motor function deterioration, and intellectual deficiency were investigated by magnetic brain imaging using T1-weighted, T2-weighted, T2*-weighted, fluid-attenuated inversion recovery, susceptibility weighted imaging (SWI) sequences...
February 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29358368/antibody-detection-by-agglutination-pcr-adap-enables-early-diagnosis-of-hiv-infection-by-oral-fluid-analysis
#6
Cheng-Ting Tsai, Peter V Robinson, Felipe de Jesus Cortez, Maria L B Elma, David Seftel, Narges Pourmandi, Mark W Pandori, Carolyn R Bertozzi
Oral fluid (OF) is a highly effective substrate for population-based HIV screening efforts, as it is noninfectious and significantly easier to collect than blood. However, anti-HIV antibodies are found at far lower concentrations in OF compared with blood, leading to poor sensitivity and a longer period of time from infection to detection threshold. Thus, despite its inherent advantages in sample collection, OF is not widely used for population screening. Here we report the development of an HIV OF assay based on Antibody Detection by Agglutination-PCR (ADAP) technology...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29227443/associations-between-medicare-part-d-and-out-of-pocket-spending-hiv-viral-load-adherence-and-adap-use-in-dual-eligibles-with-hiv
#7
Nadya Belenky, Brian W Pence, Stephen R Cole, Stacie B Dusetzina, Andrew Edmonds, Jonathan Oberlander, Michael W Plankey, Adebola Adedimeji, Tracey E Wilson, Jennifer Cohen, Mardge H Cohen, Joel E Milam, Elizabeth T Golub, Adaora A Adimora
BACKGROUND: The implementation of Medicare part D on January 1, 2006 required all adults who were dually enrolled in Medicaid and Medicare (dual eligibles) to transition prescription drug coverage from Medicaid to Medicare part D. Changes in payment systems and utilization management along with the loss of Medicaid protections had the potential to disrupt medication access, with uncertain consequences for dual eligibles with human immunodeficiency virus (HIV) who rely on consistent prescription coverage to suppress their HIV viral load (VL)...
January 2018: Medical Care
https://www.readbyqxmd.com/read/29192064/fyn-binding-protein-adap-supports-actin-organization-in-podocytes
#8
Zhenzhen Wu, Natalya A Blessing, Jeffrey S Simske, Leslie A Bruggeman
The renal podocyte is central to the filtration function of the kidney that is dependent on maintaining both highly organized, branched cell structures forming foot processes, and a unique cell-cell junction, the slit diaphragm. Our recent studies investigating the developmental formation of the slit diaphragm identified a novel claudin family tetraspannin, TM4SF10, which is a binding partner for ADAP (also known as Fyn binding protein Fyb). To investigate the role of ADAP in podocyte function in relation to Fyn and TM4SF10, we examined ADAP knockout (KO) mice and podocytes...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29127148/ubc9-binds-to-adap-and-is-required-for-rap1-membrane-recruitment-rac1-activation-and-integrin-mediated-t-cell-adhesion
#9
Yiwei Xiong, Chengjin Ye, Naiqi Yang, Madanqi Li, Hebin Liu
Although the immune adaptor adhesion and degranulation-promoting adaptor protein (ADAP) acts as a key mediator of integrin inside-out signaling leading to T cell adhesion, the regulation of this adaptor during integrin activation and clustering remains unclear. We now identify Ubc9, the sole small ubiquitin-related modifier E2 conjugase, as an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion...
December 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29076734/adap-gc-3-2-graphical-software-tool-for-efficient-spectral-deconvolution-of-gas-chromatography-high-resolution-mass-spectrometry-metabolomics-data
#10
Aleksandr Smirnov, Wei Jia, Douglas I Walker, Dean P Jones, Xiuxia Du
ADAP-GC is an automated computational workflow for extracting metabolite information from raw, untargeted gas chromatography-mass spectrometry metabolomics data. Deconvolution of coeluting analytes is a critical step in the workflow, and the underlying algorithm is able to extract fragmentation mass spectra of coeluting analytes with high accuracy. However, its latest version ADAP-GC 3.0 was not user-friendly. To make ADAP-GC easier to use, we have developed ADAP-GC 3.2 and describe here the improvements on three aspects...
January 5, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29048969/school-based-curriculum-to-improve-depression-literacy-among-us-secondary-school-students-a-randomized-effectiveness-trial
#11
RANDOMIZED CONTROLLED TRIAL
Karen Swartz, Rashelle J Musci, Mary Beth Beaudry, Kathryn Heley, Leslie Miller, Clarissa Alfes, Lisa Townsend, Graham Thornicroft, Holly C Wilcox
OBJECTIVES: To determine the effectiveness of a universal school-based depression education program. METHODS: In 2012-2015, we matched 6679 students from 66 secondary schools into pairs by state (Maryland, Delaware, Pennsylvania, Michigan, and Oklahoma) and randomized to the Adolescent Depression Awareness Program (ADAP; n = 3681) or to a waitlist control condition (n = 2998). Trained teachers delivered ADAP as part of the health education curriculum to students aged 14 to 15 years...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29039984/financial-barriers-and-lapses-in-treatment-and-care-of-hiv-infected-adults-in-a-southern-state-in-the-united-states
#12
David A Wohl, Rita K Kuwahara, Kamran Javadi, Christine Kirby, David L Rosen, Sonia Napravnik, Claire Farel
Antiretroviral (ARV) adherence has largely been considered from the perspective of an individual's behavior with less attention given to potential structural causes for lapses in treatment, such as the cost of medications and care. HIV medication expense is typically covered by third party payers. However, private insurance premiums and deductibles may rise, or policies terminated such as with a change in employment. Likewise, a patient's eligibility for publicly funded coverage like state AIDS Drug Assistance Programs (ADAP) or Medicaid can also be lost...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28891404/adapted-morris-water-maze-protocol-to-prevent-interference-from-confounding-motor-deficits-on-cognitive-functioning
#13
Mattias De Coninck, Debby Van Dam, Chris Van Ginneken, Peter Paul De Deyn
Purpose/aim of the study: Cognitive functioning in the Morris Water Maze (MWM) is assumed to be reflected by path length. In this study, the interference of motor deficits, as a confounding factor on cognitive functioning, was assessed by means of a lateralization study with hemicerebellectomized (HCX) mice. This model is characterized by motor deficits restricted to the lesion side, allowing comparison within the model itself (left vs. right), rather than the effect of the manipulation on this measure (experimental vs...
September 10, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28817460/high-demand-for-psychotherapy-in-patients-with-inflammatory-bowel-disease
#14
Thomas Klag, Nazar Mazurak, Laura Fantasia, Juliane Schwille-Kiuntke, Andreas Kirschniak, Claudius Falch, Martin Goetz, Nisar P Malek, Paul Enck, Jan Wehkamp
BACKGROUND: The relative contribution of psychological factors to the onset and course of inflammatory bowel diseases (IBD) is a matter of constant debate since its beginning, as is the clinical need and the efficacy of psychotherapeutic interventions. However, the perspective of patients with IBD has largely been ignored in this debate. METHODS: Psychometric tests including the Short-Form IBD Questionnaire (SIBDQ), the ADAP test measuring demand for psychotherapy, and the Fear-of-Progression Questionnaire Short Form as well as disease-related questions were positioned on the internet between December 2014 and January 2016...
August 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28682658/effects-of-health-insurance-interruption-on-loss-of-hypertension-control-in-women-with-and-women-without-hiv
#15
Andrew Edmonds, Christina Ludema, Joseph J Eron, Stephen R Cole, Adebola A Adedimeji, Mardge H Cohen, Hannah L Cooper, Margaret Fischl, Mallory O Johnson, Denise D Krause, Dan Merenstein, Joel Milam, Tracey E Wilson, Adaora A Adimora
BACKGROUND: Among low-income women with and without HIV, it is a priority to reduce age-related comorbidities, including hypertension and its sequelae. Because consistent health insurance access has been identified as an important factor in controlling many chronic diseases, we estimated the effects of coverage interruption on loss of hypertension control in a cohort of women in the United States. METHODS: We analyzed prospective, longitudinal data from the Women's Interagency HIV Study...
December 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28449128/comprehensive-ryan-white-assistance-and-human-immunodeficiency-virus-clinical-outcomes-retention-in-care-and-viral-suppression-in-a-medicaid-nonexpansion-state
#16
Karen L Diepstra, Anne G Rhodes, Rose S Bono, Sonam Patel, Lauren E Yerkes, April D Kimmel
Background: Knowledge gaps remain about how the Ryan White human immunodeficiency virus (HIV)/AIDS Program (RW) contributes to health outcomes. We examined the association between different RW service classes and retention in care (RiC) or viral suppression (VS). Methods: We identified Virginians engaged in any HIV care between 1 January and 31 December 2014. RW beneficiaries were classified by receipt of ≥1 service from 3 classes: Core medical, Support, and insurance and/or direct medication assistance through the AIDS Drug Assistance Program (ADAP)...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28260246/fulfilling-the-common-core-standards-and-meeting-students-needs-for-depression-education-adap
#17
Mary Beth Beaudry, Lisa Townsend, Kathryn Heley, Emma Cogan, Nicholas Schweizer, Karen Swartz
No abstract text is available yet for this article.
April 2017: Journal of School Health
https://www.readbyqxmd.com/read/27926672/mechanisms-predisposing-factors-and-prognosis-of-intra-operative-vertebral-subluxation-during-pedicle-subtraction-osteotomy-in-surgical-correction-of-thoracolumbar-kyphosis-secondary-to-ankylosing-spondylitis
#18
Bang-Ping Qian, Sai-Hu Mao, Jun Jiang, Bin Wang, Yong Qiu
STUDY DESIGN: A retrospective study. OBJECTIVE: To analyze the mechanisms, predisposing factors and prognosis of the intraoperative vertebral subluxation (VS) during pedicle subtraction osteotomy (PSO) for thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: VS is one of the most daunting challenges that surgeons encounter during PSO closure, especially in AS patients with ankylosed and mostly osteoporotic spine...
December 6, 2016: Spine
https://www.readbyqxmd.com/read/27763995/impact-of-health-insurance-adap-and-income-on-hiv-viral-suppression-among-us-women-in-the-women-s-interagency-hiv-study-2006-2009
#19
Christina Ludema, Stephen R Cole, Joseph J Eron, Andrew Edmonds, G Mark Holmes, Kathryn Anastos, Jennifer Cocohoba, Mardge Cohen, Hannah L F Cooper, Elizabeth T Golub, Seble Kassaye, Deborah Konkle-Parker, Lisa Metsch, Joel Milam, Tracey E Wilson, Adaora A Adimora
BACKGROUND: Implementation of the Affordable Care Act motivates assessment of health insurance and supplementary programs, such as the AIDS Drug Assistance Program (ADAP) on health outcomes of HIV-infected people in the United States. We assessed the effects of health insurance, ADAP, and income on HIV viral load suppression. METHODS: We used existing cohort data from the HIV-infected participants of the Women's Interagency HIV Study. Cox proportional hazards models were used to estimate the time from 2006 to unsuppressed HIV viral load (>200 copies/mL) among those with Medicaid, private, Medicare, or other public insurance, and no insurance, stratified by the use of ADAP...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27746719/integrin-activation-through-the-hematopoietic-adapter-molecule-adap-regulates-dendritic-development-of-hippocampal-neurons
#20
Marlen Thiere, Stefanie Kliche, Bettina Müller, Jan Teuber, Isabell Nold, Oliver Stork
Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an "inside-out" activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and branching of dendrites. In this study, we investigated the role of the hematopoietic adaptor protein adhesion and degranulation promoting adapter protein (ADAP) in these processes. We demonstrate the expression of ADAP in the developing and adult nervous hippocampus, and in outgrowing dendrites of primary hippocampal neurons...
2016: Frontiers in Molecular Neuroscience
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