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https://www.readbyqxmd.com/read/29127148/ubc9-binds-to-adap-and-is-required-for-rap1-membrane-recruitment-rac1-activation-and-integrin-mediated-t-cell-adhesion
#1
Yiwei Xiong, Chengjin Ye, Naiqi Yang, Madanqi Li, Hebin Liu
Although the immune adaptor adhesion and degranulation-promoting adaptor protein (ADAP) acts as a key mediator of integrin inside-out signaling leading to T cell adhesion, the regulation of this adaptor during integrin activation and clustering remains unclear. We now identify Ubc9, the sole small ubiquitin-related modifier E2 conjugase, as an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion...
November 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29076734/adap-gc-3-2-graphical-software-tool-for-efficient-spectral-deconvolution-of-gas-chromatography-high-resolution-mass-spectrometry-metabolomics-data
#2
Aleksandr Smirnov, Wei Jia, Douglas I Walker, Dean P Jones, Xiuxia Du
ADAP-GC is an automated computational workflow for extracting metabolite information from raw, untargeted gas chromatography-mass spectrometry metabolomics data. Deconvolution of coeluting analytes is a critical step in the workflow, and the underlying algorithm is able to extract fragmentation mass spectra of coeluting analytes with high accuracy. However, its latest version ADAP-GC 3.0 was not user-friendly. To make ADAP-GC easier to use, we have developed ADAP-GC 3.2 and describe here the improvements on three aspects...
November 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29048969/school-based-curriculum-to-improve-depression-literacy-among-us-secondary-school-students-a-randomized-effectiveness-trial
#3
RANDOMIZED CONTROLLED TRIAL
Karen Swartz, Rashelle J Musci, Mary Beth Beaudry, Kathryn Heley, Leslie Miller, Clarissa Alfes, Lisa Townsend, Graham Thornicroft, Holly C Wilcox
OBJECTIVES: To determine the effectiveness of a universal school-based depression education program. METHODS: In 2012-2015, we matched 6679 students from 66 secondary schools into pairs by state (Maryland, Delaware, Pennsylvania, Michigan, and Oklahoma) and randomized to the Adolescent Depression Awareness Program (ADAP; n = 3681) or to a waitlist control condition (n = 2998). Trained teachers delivered ADAP as part of the health education curriculum to students aged 14 to 15 years...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29039984/financial-barriers-and-lapses-in-treatment-and-care-of-hiv-infected-adults-in-a-southern-state-in-the-united-states
#4
David A Wohl, Rita K Kuwahara, Kamran Javadi, Christine Kirby, David L Rosen, Sonia Napravnik, Claire Farel
Antiretroviral (ARV) adherence has largely been considered from the perspective of an individual's behavior with less attention given to potential structural causes for lapses in treatment, such as the cost of medications and care. HIV medication expense is typically covered by third party payers. However, private insurance premiums and deductibles may rise, or policies terminated such as with a change in employment. Likewise, a patient's eligibility for publicly funded coverage like state AIDS Drug Assistance Programs (ADAP) or Medicaid can also be lost...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28891404/adapted-morris-water-maze-protocol-to-prevent-interference-from-confounding-motor-deficits-on-cognitive-functioning
#5
Mattias De Coninck, Debby Van Dam, Chris Van Ginneken, Peter Paul De Deyn
Purpose/aim of the study: Cognitive functioning in the Morris Water Maze (MWM) is assumed to be reflected by path length. In this study, the interference of motor deficits, as a confounding factor on cognitive functioning, was assessed by means of a lateralization study with hemicerebellectomized (HCX) mice. This model is characterized by motor deficits restricted to the lesion side, allowing comparison within the model itself (left vs. right), rather than the effect of the manipulation on this measure (experimental vs...
September 10, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28817460/high-demand-for-psychotherapy-in-patients-with-inflammatory-bowel-disease
#6
Thomas Klag, Nazar Mazurak, Laura Fantasia, Juliane Schwille-Kiuntke, Andreas Kirschniak, Claudius Falch, Martin Goetz, Nisar P Malek, Paul Enck, Jan Wehkamp
BACKGROUND: The relative contribution of psychological factors to the onset and course of inflammatory bowel diseases (IBD) is a matter of constant debate since its beginning, as is the clinical need and the efficacy of psychotherapeutic interventions. However, the perspective of patients with IBD has largely been ignored in this debate. METHODS: Psychometric tests including the Short-Form IBD Questionnaire (SIBDQ), the ADAP test measuring demand for psychotherapy, and the Fear-of-Progression Questionnaire Short Form as well as disease-related questions were positioned on the internet between December 2014 and January 2016...
August 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28682658/effects-of-health-insurance-interruption-on-loss-of-hypertension-control-in-women-with-and-women-without-hiv
#7
Andrew Edmonds, Christina Ludema, Joseph J Eron, Stephen R Cole, Adebola A Adedimeji, Mardge H Cohen, Hannah L Cooper, Margaret Fischl, Mallory O Johnson, Denise D Krause, Dan Merenstein, Joel Milam, Tracey E Wilson, Adaora A Adimora
BACKGROUND: Among low-income women with and without HIV, it is a priority to reduce age-related comorbidities, including hypertension and its sequelae. Because consistent health insurance access has been identified as an important factor in controlling many chronic diseases, we estimated the effects of coverage interruption on loss of hypertension control in a cohort of women in the United States. METHODS: We analyzed prospective, longitudinal data from the Women's Interagency HIV Study...
July 6, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28449128/comprehensive-ryan-white-assistance-and-human-immunodeficiency-virus-clinical-outcomes-retention-in-care-and-viral-suppression-in-a-medicaid-nonexpansion-state
#8
Karen L Diepstra, Anne G Rhodes, Rose S Bono, Sonam Patel, Lauren E Yerkes, April D Kimmel
Background: Knowledge gaps remain about how the Ryan White human immunodeficiency virus (HIV)/AIDS Program (RW) contributes to health outcomes. We examined the association between different RW service classes and retention in care (RiC) or viral suppression (VS). Methods: We identified Virginians engaged in any HIV care between 1 January and 31 December 2014. RW beneficiaries were classified by receipt of ≥1 service from 3 classes: Core medical, Support, and insurance and/or direct medication assistance through the AIDS Drug Assistance Program (ADAP)...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28260246/fulfilling-the-common-core-standards-and-meeting-students-needs-for-depression-education-adap
#9
Mary Beth Beaudry, Lisa Townsend, Kathryn Heley, Emma Cogan, Nicholas Schweizer, Karen Swartz
No abstract text is available yet for this article.
April 2017: Journal of School Health
https://www.readbyqxmd.com/read/27926672/mechanisms-predisposing-factors-and-prognosis-of-intra-operative-vertebral-subluxation-during-pedicle-subtraction-osteotomy-in-surgical-correction-of-thoracolumbar-kyphosis-secondary-to-ankylosing-spondylitis
#10
Bang-Ping Qian, Sai-Hu Mao, Jun Jiang, Bin Wang, Yong Qiu
STUDY DESIGN: A retrospective study. OBJECTIVE: To analyze the mechanisms, predisposing factors and prognosis of the intraoperative vertebral subluxation (VS) during pedicle subtraction osteotomy (PSO) for thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: VS is one of the most daunting challenges that surgeons encounter during PSO closure, especially in AS patients with ankylosed and mostly osteoporotic spine...
December 6, 2016: Spine
https://www.readbyqxmd.com/read/27763995/impact-of-health-insurance-adap-and-income-on-hiv-viral-suppression-among-us-women-in-the-women-s-interagency-hiv-study-2006-2009
#11
Christina Ludema, Stephen R Cole, Joseph J Eron, Andrew Edmonds, G Mark Holmes, Kathryn Anastos, Jennifer Cocohoba, Mardge Cohen, Hannah L F Cooper, Elizabeth T Golub, Seble Kassaye, Deborah Konkle-Parker, Lisa Metsch, Joel Milam, Tracey E Wilson, Adaora A Adimora
BACKGROUND: Implementation of the Affordable Care Act motivates assessment of health insurance and supplementary programs, such as the AIDS Drug Assistance Program (ADAP) on health outcomes of HIV-infected people in the United States. We assessed the effects of health insurance, ADAP, and income on HIV viral load suppression. METHODS: We used existing cohort data from the HIV-infected participants of the Women's Interagency HIV Study. Cox proportional hazards models were used to estimate the time from 2006 to unsuppressed HIV viral load (>200 copies/mL) among those with Medicaid, private, Medicare, or other public insurance, and no insurance, stratified by the use of ADAP...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27746719/integrin-activation-through-the-hematopoietic-adapter-molecule-adap-regulates-dendritic-development-of-hippocampal-neurons
#12
Marlen Thiere, Stefanie Kliche, Bettina Müller, Jan Teuber, Isabell Nold, Oliver Stork
Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an "inside-out" activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and branching of dendrites. In this study, we investigated the role of the hematopoietic adaptor protein adhesion and degranulation promoting adapter protein (ADAP) in these processes. We demonstrate the expression of ADAP in the developing and adult nervous hippocampus, and in outgrowing dendrites of primary hippocampal neurons...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27697866/shp-1-acts-as-a-key-regulator-of-alloresponses-by-modulating-lfa-1-mediated-adhesion-in-primary-murine-t-cells
#13
Martin G Sauer, Jessica Herbst, Ulf Diekmann, Christopher E Rudd, Christian Kardinal
The clinical potential of transplantation is often reduced by T cell-mediated alloresponses that cause graft rejection or graft-versus-host disease. Integrin-mediated adhesion between alloreactive T cells and antigen-presenting cells is essential for allorejection. The identity of the signaling events needed for the activation of integrins such as LFA-1 is poorly understood. Here, we identified a novel role of the protein tyrosine phosphatase SHP-1 in the regulation of murine LFA-1-mediated adhesion in an allograft setting...
December 15, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27621757/therapy-related-myeloid-neoplasms-what-have-we-learned-so-far
#14
REVIEW
Mohammad Faizan Zahid, Aric Parnes, Bipin N Savani, Mark R Litzow, Shahrukh K Hashmi
Therapy-related myeloid neoplasms are neoplastic processes arising as a result of chemotherapy, radiation therapy, or a combination of these modalities given for a primary condition. The disease biology varies based on the etiology and treatment modalities patients receive for their primary condition. Topoisomerase II inhibitor therapy results in balanced translocations. Alkylating agents, characteristically, give rise to more complex karyotypes and mutations in p53. Other etiologies include radiation therapy, high-dose chemotherapy with autologous stem cell transplantation and telomere dysfunction...
August 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27613702/whole-body-perfusion-in-patients-undergoing-frozen-elephant-trunk-for-type-a-acute-aortic-dissections
#15
Giangiuseppe Cappabianca, Claudio Roscitano, Samuele Bichi, Antonio Cricco, Matteo Parrinello, Cesare Beghi, Giovanni Albano, Giampiero Esposito
The Frozen Elephant Trunk (FET) can be adopted in selected type A acute aortic dissections (TAAAD). During FET, a prolonged distal circulatory arrest exposes the spine and visceral organs to potential ischemic injuries. Antegrade distal aortic perfusion (ADAP) could minimize this risk: we describe the technical aspects of the simultaneous use of antegrade cerebral perfusion (ACP) and ADAP achieving a "Whole Body Perfusion" (WBP) during FET.
September 9, 2016: Perfusion
https://www.readbyqxmd.com/read/27605210/adap-plays-a-pivotal-role-in-cd4-t-cell-activation-but-is-only-marginally-involved-in-cd8-t-cell-activation-differentiation-and-immunity-to-pathogens
#16
Gerald P Parzmair, Marcus Gereke, Oxana Haberkorn, Michaela Annemann, Lisa Podlasly, Stefanie Kliche, Annegret Reinhold, Burkhart Schraven, Dunja Bruder
The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflammatory cytokines (e.g., IFN-γ and IL-2). Strikingly, despite its well-established role in T cells, previous studies did not distinguish between CD4(+) and CD8(+) T cells, and thus, it is unknown whether ADAP fulfills equally important functions in both T cell subsets...
February 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27598849/phylogeographic-differentiation-versus-transcriptomic-adaptation-to-warm-temperatures-in-zostera-marina-a-globally-important-seagrass
#17
A Jueterbock, S U Franssen, N Bergmann, J Gu, J A Coyer, T B H Reusch, E Bornberg-Bauer, J L Olsen
Populations distributed across a broad thermal cline are instrumental in addressing adap-tation to increasing temperatures under global warming. Using a space-for-time substi-tution design, we tested for parallel adaptation to warm-temperatures along two inde-pendent thermal clines in Zostera marina, the most widely distributed seagrass in the temperate northern hemisphere. A North-South pair of populations was sampled along the European and North American coasts and exposed to a simulated heat wave in a common-garden mesocosm...
September 6, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27559021/a-bayesian-response-adaptive-trial-in-tuberculosis-the-endtb-trial
#18
Matteo Cellamare, Steffen Ventz, Elisabeth Baudin, Carole D Mitnick, Lorenzo Trippa
PURPOSE: To evaluate the use of Bayesian adaptive randomization for clinical trials of new treatments for multidrug-resistant tuberculosis. METHODS: We built a response-adaptive randomization procedure, adapting on two preliminary outcomes for tuberculosis patients in a trial with five experimental regimens and a control arm. The primary study outcome is treatment success after 73 weeks from randomization; preliminary responses are culture conversion at 8 weeks and treatment success at 39 weeks...
February 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/27532862/proposing-a-compartmental-model-for-leprosy-and-parameterizing-using-regional-incidence-in-brazil
#19
Rebecca Lee Smith
Hansen's disease (HD), or leprosy, is still considered a public health risk in much of Brazil. Understanding the dynamics of the infection at a regional level can aid in identification of targets to improve control. A compartmental continuous-time model for leprosy dynamics was designed based on understanding of the biology of the infection. The transmission coefficients for the model and the rate of detection were fit for each region using Approximate Bayesian Computation applied to paucibacillary and multibacillary incidence data over the period of 2000 to 2010, and model fit was validated on incidence data from 2011 to 2012...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27521337/adhesion-and-degranulation-promoting-adapter-protein-promotes-cd8-t-cell-differentiation-and-resident-memory-formation-and-function-during-an-acute-infection
#20
Jessica K Fiege, Lalit K Beura, Brandon J Burbach, Yoji Shimizu
During acute infections, naive Ag-specific CD8 T cells are activated and differentiate into effector T cells, most of which undergo contraction after pathogen clearance. A small population of CD8 T cells persists as memory to protect against future infections. We investigated the role of adhesion- and degranulation-promoting adapter protein (ADAP) in promoting CD8 T cell responses to a systemic infection. Naive Ag-specific CD8 T cells lacking ADAP exhibited a modest expansion defect early after Listeria monocytogenes or vesicular stomatitis virus infection but comparable cytolytic function at the peak of response...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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