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https://www.readbyqxmd.com/read/27763995/impact-of-health-insurance-adap-and-income-on-hiv-viral-suppression-among-us-women-in-the-women-s-interagency-hiv-study-2006-2009
#1
Christina Ludema, Stephen R Cole, Joseph J Eron, Andrew Edmonds, G Mark Holmes, Kathryn Anastos, Jennifer Cocohoba, Mardge Cohen, Hannah L F Cooper, Elizabeth T Golub, Seble Kassaye, Deborah Konkle-Parker, Lisa Metsch, Joel Milam, Tracey E Wilson, Adaora A Adimora
BACKGROUND: Implementation of the Affordable Care Act motivates assessment of health insurance and supplementary programs, such as the AIDS Drug Assistance Program (ADAP) on health outcomes of HIV-infected people in the United States. We assessed the effects of health insurance, ADAP, and income on HIV viral load suppression. METHODS: We used existing cohort data from the HIV-infected participants of the Women's Interagency HIV Study. Cox proportional hazards models were used to estimate the time from 2006 to unsuppressed HIV viral load (>200 copies/mL) among those with Medicaid, private, Medicare, or other public insurance, and no insurance, stratified by the use of ADAP...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27746719/integrin-activation-through-the-hematopoietic-adapter-molecule-adap-regulates-dendritic-development-of-hippocampal-neurons
#2
Marlen Thiere, Stefanie Kliche, Bettina Müller, Jan Teuber, Isabell Nold, Oliver Stork
Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an "inside-out" activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and branching of dendrites. In this study, we investigated the role of the hematopoietic adaptor protein adhesion and degranulation promoting adapter protein (ADAP) in these processes. We demonstrate the expression of ADAP in the developing and adult nervous hippocampus, and in outgrowing dendrites of primary hippocampal neurons...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27697866/shp-1-acts-as-a-key-regulator-of-alloresponses-by-modulating-lfa-1-mediated-adhesion-in-primary-murine-t-cells
#3
Martin G Sauer, Jessica Herbst, Ulf Diekmann, Christopher E Rudd, Christian Kardinal
The clinical potential of transplantation is often reduced by T cell-mediated alloresponses that cause graft rejection or graft-versus-host disease. Integrin-mediated adhesion between alloreactive T cells and antigen-presenting cells is essential for allorejection. The identity of the signaling events needed for the activation of integrins such as LFA-1 is poorly understood. Here, we identified a novel role of the protein tyrosine phosphatase SHP-1 in the regulation of murine LFA-1-mediated adhesion in an allograft setting...
December 15, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27621757/therapy-related-myeloid-neoplasms-what-have-we-learned-so-far
#4
REVIEW
Mohammad Faizan Zahid, Aric Parnes, Bipin N Savani, Mark R Litzow, Shahrukh K Hashmi
Therapy-related myeloid neoplasms are neoplastic processes arising as a result of chemotherapy, radiation therapy, or a combination of these modalities given for a primary condition. The disease biology varies based on the etiology and treatment modalities patients receive for their primary condition. Topoisomerase II inhibitor therapy results in balanced translocations. Alkylating agents, characteristically, give rise to more complex karyotypes and mutations in p53. Other etiologies include radiation therapy, high-dose chemotherapy with autologous stem cell transplantation and telomere dysfunction...
August 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27613702/whole-body-perfusion-in-patients-undergoing-frozen-elephant-trunk-for-type-a-acute-aortic-dissections
#5
Giangiuseppe Cappabianca, Claudio Roscitano, Samuele Bichi, Antonio Cricco, Matteo Parrinello, Cesare Beghi, Giovanni Albano, Giampiero Esposito
The Frozen Elephant Trunk (FET) can be adopted in selected type A acute aortic dissections (TAAAD). During FET, a prolonged distal circulatory arrest exposes the spine and visceral organs to potential ischemic injuries. Antegrade distal aortic perfusion (ADAP) could minimize this risk: we describe the technical aspects of the simultaneous use of antegrade cerebral perfusion (ACP) and ADAP achieving a "Whole Body Perfusion" (WBP) during FET.
September 9, 2016: Perfusion
https://www.readbyqxmd.com/read/27605210/adap-plays-a-pivotal-role-in-cd4-t-cell-activation-but-is-only-marginally-involved-in-cd8-t-cell-activation-differentiation-and-immunity-to-pathogens
#6
Gerald P Parzmair, Marcus Gereke, Oxana Haberkorn, Michaela Annemann, Lisa Podlasly, Stefanie Kliche, Annegret Reinhold, Burkhart Schraven, Dunja Bruder
The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflammatory cytokines (e.g., IFN-γ and IL-2). Strikingly, despite its well-established role in T cells, previous studies did not distinguish between CD4(+) and CD8(+) T cells, and thus, it is unknown whether ADAP fulfills equally important functions in both T cell subsets...
September 7, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27598849/phylogeographic-differentiation-versus-transcriptomic-adaptation-to-warm-temperatures-in-zostera-marina-a-globally-important-seagrass
#7
A Jueterbock, S U Franssen, N Bergmann, J Gu, J A Coyer, T B H Reusch, E Bornberg-Bauer, J L Olsen
Populations distributed across a broad thermal cline are instrumental in addressing adap-tation to increasing temperatures under global warming. Using a space-for-time substi-tution design, we tested for parallel adaptation to warm-temperatures along two inde-pendent thermal clines in Zostera marina, the most widely distributed seagrass in the temperate northern hemisphere. A North-South pair of populations was sampled along the European and North American coasts and exposed to a simulated heat wave in a common-garden mesocosm...
September 6, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27559021/a-bayesian-response-adaptive-trial-in-tuberculosis-the-endtb-trial
#8
Matteo Cellamare, Steffen Ventz, Elisabeth Baudin, Carole D Mitnick, Lorenzo Trippa
PURPOSE: To evaluate the use of Bayesian adaptive randomization for clinical trials of new treatments for multidrug-resistant tuberculosis. METHODS: We built a response-adaptive randomization procedure, adapting on two preliminary outcomes for tuberculosis patients in a trial with five experimental regimens and a control arm. The primary study outcome is treatment success after 73 weeks from randomization; preliminary responses are culture conversion at 8 weeks and treatment success at 39 weeks...
August 23, 2016: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/27532862/proposing-a-compartmental-model-for-leprosy-and-parameterizing-using-regional-incidence-in-brazil
#9
Rebecca Lee Smith
Hansen's disease (HD), or leprosy, is still considered a public health risk in much of Brazil. Understanding the dynamics of the infection at a regional level can aid in identification of targets to improve control. A compartmental continuous-time model for leprosy dynamics was designed based on understanding of the biology of the infection. The transmission coefficients for the model and the rate of detection were fit for each region using Approximate Bayesian Computation applied to paucibacillary and multibacillary incidence data over the period of 2000 to 2010, and model fit was validated on incidence data from 2011 to 2012...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27521337/adhesion-and-degranulation-promoting-adapter-protein-promotes-cd8-t-cell-differentiation-and-resident-memory-formation-and-function-during-an-acute-infection
#10
Jessica K Fiege, Lalit K Beura, Brandon J Burbach, Yoji Shimizu
During acute infections, naive Ag-specific CD8 T cells are activated and differentiate into effector T cells, most of which undergo contraction after pathogen clearance. A small population of CD8 T cells persists as memory to protect against future infections. We investigated the role of adhesion- and degranulation-promoting adapter protein (ADAP) in promoting CD8 T cell responses to a systemic infection. Naive Ag-specific CD8 T cells lacking ADAP exhibited a modest expansion defect early after Listeria monocytogenes or vesicular stomatitis virus infection but comparable cytolytic function at the peak of response...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27494360/conversation-analysis-in-the-differentiation-of-psychogenic-nonepileptic-and-epileptic-seizures-in-pediatric-and-adolescent-settings
#11
Cesare Maria Cornaggia, Gabriella Di Rosa, Maria Polita, Adriana Magaudda, Cecilia Perin, Massimiliano Beghi
The differential diagnosis of epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES) is often difficult, especially in pediatric and adolescent settings. Conversation analysis (CA) can be a worthwhile diagnostic tool in adults. The aim of this study was to assess the diagnostic value of CA in Italian children and adolescents. Ten patients (seven females and three males), diagnosed using video-EEG as having either ES or PNES, underwent a video-recorded interview by a physician from outside the center specifically trained for this purpose...
September 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27493772/does-density-influence-relative-growth-performance-of-farm-wild-and-f1-hybrid-atlantic-salmon-in-semi-natural-and-hatchery-common-garden-conditions
#12
Alison C Harvey, Gareth Juleff, Gary R Carvalho, Martin I Taylor, Monica F Solberg, Simon Creer, Lise Dyrhovden, Ivar-Helge Matre, Kevin A Glover
The conditions encountered by Atlantic salmon, Salmo salar L., in aquaculture are markedly different from the natural environment. Typically, farmed salmon experience much higher densities than wild individuals, and may therefore have adapted to living in high densities. Previous studies have demonstrated that farmed salmon typically outgrow wild salmon by large ratios in the hatchery, but these differences are much less pronounced in the wild. Such divergence in growth may be explained partly by the offspring of wild salmon experiencing higher stress and thus lower growth when compared under high-density farming conditions...
July 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27461032/adap-gc-3-0-improved-peak-detection-and-deconvolution-of-co-eluting-metabolites-from-gc-tof-ms-data-for-metabolomics-studies
#13
Yan Ni, Mingming Su, Yunping Qiu, Wei Jia, Xiuxia Du
ADAP-GC is an automated computational pipeline for untargeted, GC/MS-based metabolomics studies. It takes raw mass spectrometry data as input and carries out a sequence of data processing steps including construction of extracted ion chromatograms, detection of chromatographic peak features, deconvolution of coeluting compounds, and alignment of compounds across samples. Despite the increased accuracy from the original version to version 2.0 in terms of extracting metabolite information for identification and quantitation, ADAP-GC 2...
September 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27459294/proton-affinity-of-isomeric-dipeptides-containing-lysine-and-non-proteinogenic-lysine-homologues
#14
Patrick Batoon, Jianhua Ren
Conformational effects on the proton affinity of oligopeptides have been studied using six alanine (A)-based acetylated dipeptides containing a basic probe that is placed closest to either the C- or the N-terminus. The basic probe includes Lysine (Lys) and two nonproteinogenic Lys-homologues, ornithine (Orn) and 2,3-diaminopropionic acid (Dap). The proton affinities of the peptides have been determined using the extended Cooks kinetic method in a triple quadrupole mass spectrometer. Computational studies have been carried out to search for the lowest energy conformers and to calculate theoretical proton affinities as well as various molecular properties using the density functional theory...
August 18, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27379055/bifidobacteria-and-their-role-as-members-of-the-human-gut-microbiota
#15
REVIEW
Amy O'Callaghan, Douwe van Sinderen
Members of the genus Bifidobacterium are among the first microbes to colonize the human gastrointestinal tract and are believed to exert positive health benefits on their host. Due to their purported health-promoting properties, bifidobacteria have been incorporated into many functional foods as active ingredients. Bifidobacteria naturally occur in a range of ecological niches that are either directly or indirectly connected to the animal gastrointestinal tract, such as the human oral cavity, the insect gut and sewage...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27360411/differences-in-the-rate-of-locomotor-adapation-of-anterior-cruciate-ligament-reconstructed-individuals-1492-board-145-june-2-9-00-am-10-30-am
#16
Matthew J Terza, Jaimie A Roper, Chris J Hass, Chris J Hass
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27349342/a-mutation-within-the-sh2-domain-of-slp-76-regulates-the-tissue-distribution-and-cytokine-production-of-inkt-cells-in-mice
#17
Claudia Danzer, Anna Koller, Julia Baier, Harald Arnold, Claudia Giessler, Robert Opoka, Stephanie Schmidt, Maike Willers, Sidonia Mihai, Hans Parsch, Stefan Wirtz, Christoph Daniel, Annegret Reinhold, Swen Engelmann, Stefanie Kliche, Christian Bogdan, Kasper Hoebe, Jochen Mattner
TCR ligation is critical for the selection, activation, and integrin expression of T lymphocytes. Here, we explored the role of the TCR adaptor protein slp-76 on iNKT-cell biology. Compared to B6 controls, slp-76(ace/ace) mice carrying a missense mutation (Thr428Ile) within the SH2-domain of slp-76 showed an increase in iNKT cells in the thymus and lymph nodes, but a decrease in iNKT cells in spleens and livers, along with reduced ADAP expression and cytokine response. A comparable reduction in iNKT cells was observed in the livers and spleens of ADAP-deficient mice...
September 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27346694/affordable-care-act-qualified-health-plan-enrollment-for-aids-drug-assistance-program-clients-virginia-s-experience-and-best-practices
#18
Kathleen A McManus, Robert C Rodney, Anne Rhodes, Steven Bailey, Rebecca Dillingham
With the implementation of the Affordable Care Act (ACA) in 2014, many safety net resources, including state AIDS Drug Assistance Programs (ADAPs), incorporated ACA Qualified Health Plans (QHPs) into their healthcare delivery model. This article highlights the benefits of the ACA for persons living with HIV. It also describes the range of strategies employed by state ADAPs to enroll patients in QHPs. The Virginia ADAP ACA implementation experience is described to illustrate one ADAP's shift to purchasing QHPs in addition to providing direct medications...
September 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27335501/arap-a-novel-adaptor-protein-is-required-for-tcr-signaling-and-integrin-mediated-adhesion
#19
Seung Hee Jung, Eun Hye Yoo, Mi Jin Yu, Hyeon Myeong Song, Hee Yoon Kang, Je-Yoel Cho, Jong Ran Lee
A novel adaptor protein was identified by analyzing phosphotyrosine proteomes from membrane rafts of activated T cells. This protein showed sequence similarity to a well-known T cell adaptor protein, adhesion and degranulation-promoting adaptor protein (ADAP); therefore, the novel protein was designated activation-dependent, raft-recruited ADAP-like phosphoprotein (ARAP). Suppression of ARAP impaired the major signaling pathways downstream of the TCR. ARAP associated with the Src homology 2 domain of Src homology 2-containing leukocyte protein of 76 kDa via the phosphorylation of two YDDV motifs in response to TCR stimulation...
August 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27299822/-micrornas-circulating-biomarkers-in-type-2-diabetes-mellitus-and-physical-exercise
#20
Nicolás Gómez-Banoy, Ismena Mockus
MicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific serum profiles of these molecules have been identified in high-risk patients before the development of DM2 and its chronic complications. Most importantly, these profiles can be modified with physical exercise, which is crucial in the treatment of metabolic diseases...
March 2016: Revista Médica de Chile
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