Giorgio Fm Cattaneo, Andrea M Herrmann, Sebastian A Eiden, Manuela Wieser, Elias Kellner, Soroush Doostkam, Patrick Süß, Selina Kiefer, Lisa Fauth, Christoph J Maurer, Julia Wolfertz, Björn Nitzsche, Michael Büchert, Tobias Jost, Gabriele Ihorst, Jörg Haberstroh, Christoph Mülling, Christoph Strecker, Wolf-Dirk Niesen, Mukesch J Shah, Horst Urbach, Johannes Boltze, Stephan Meckel
Selective therapeutic hypothermia (TH) showed promising preclinical results as a neuroprotective strategy in acute ischemic stroke. We aimed to assess safety and feasibility of an intracarotid cooling catheter conceived for fast and selective brain cooling during endovascular thrombectomy in an ovine stroke model.Transient middle cerebral artery occlusion (MCAO, 3 h) was performed in 20 sheep. In the hypothermia group (n = 10), selective TH was initiated 20 minutes before recanalization, and was maintained for another 3 h...
June 23, 2021: Journal of Cerebral Blood Flow and Metabolism