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https://www.readbyqxmd.com/read/29915374/maternal-overweight-and-obesity-increase-the-risk-of-fetal-acidosis-during-labor
#1
Stefan Johansson, Anna Sandström, Sven Cnattingius
OBJECTIVE: To investigate whether maternal overweight and obesity increased the risk of fetal acidosis measured in umbilical cord arterial blood after delivery. STUDY DESIGN: Population-based cohort study of 84,785 term (≥37 weeks) infants. Logistic regression was used to estimate risks of fetal acidosis in umbilical cord arterial blood. Fetal acidosis was defined as pH <7.10 or as pH <1st percentile on a normal reference curve. RESULT: Risks of fetal acidosis increased, regardless of definition, with maternal overweight and obesity severity...
June 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29912599/the-impact-of-nuchal-cord-on-umbilical-cord-blood-gas-analysis-and-ischaemia-modified-albumin-levels-in-elective-c-section
#2
Aslı Yarcı Gursoy, Burcin Ozgu, Yasemin Tasci, Tuba Candar, Salim Erkaya, Gamze Sinem Caglar
This study was designed to evaluate umbilical cord ischaemia-modified albumin (IMA) levels and the cord blood gas parameters of foetuses with or without nuchal cords, at the time of elective C-section. The cross-sectional study population consisted of the patients who were admitted to the Tertiary Care Center between February and June 2015. Women with uncomplicated single term gestations between 37 and 40 completed weeks and scheduled for elective C-sections were included in the study. Fifty cases with a nuchal cord and 50 cases without a nuchal cord were recruited...
June 18, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29909265/intrapartum-and-perinatal-results-associated-with-different-degrees-of-staining-of-meconium-stained-amniotic-fluid
#3
Vanesa Rodríguez Fernández, Carlos Nicolás López Ramón Y Cajal, Elena Marín Ortiz, Emilio Couceiro Naveira
OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29889761/association-of-obstetrician-gender-with-obstetric-interventions-and-outcomes
#4
Lynn M Yee, Emily S Miller
OBJECTIVE: To estimate whether there are differences in obstetric interventions or outcomes by the gender of the delivering physician. METHODS: We conducted a retrospective cohort study of all nulliparous women delivering singleton, vertex, live births at 37 weeks of gestation or greater at a tertiary care institution (2014-2015). Patient clinical characteristics were analyzed by delivering physician gender. The primary outcomes were delivery mode and episiotomy...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29888399/localization-of-the-motor-neuron-somata-of-geniohyoid-muscle-in-rat-a-horseradish-peroxidase-study
#5
Aimi Nadia Binti Razlan, Muzammil Ullah, Marina Yurievna Kapitonova, Norhayati Binti Liaqat Ali Khan, Syed Baharom Syed Ahmad Fuad
The aim of the study was to investigate the location of motor neuron somata of geniohyoid muscle in rat. Nine Sprague-Dawley rats were used in this study. Operations were performed under general anaesthesia. Nembutal sodium, 40 mg per kg intraperitoneally was used for anaesthesia. 0.02 to 0.05 ml of 30% horseradish peroxidase (Sigma Type VI) solution in normal saline was injected into the exposed right geniohyoid muscle. After 48 hr, the animals were fixed by perfusion through left ventricle of heart, first by 100 ml normal saline and then with 500 ml of 1...
June 11, 2018: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29888259/a-comprehensive-evaluation-of-the-predictive-abilities-of-fetal-electrocardiogram-derived-parameters-during-labor-in-newborn-acidemia-our-institutional-experience
#6
Ning Tian, Weiyuan Zhang
This study aimed to identify cardiotocography patterns that discriminate fetal acidemia newborns by comprehensively evaluating the parameters obtained from Holter monitoring during delivery. Between June 1, 2015, and August 1, 2016, a prospective observational study of 85 patients was conducted using fetal Holter monitoring at the Beijing Obstetrics and Gynecology Hospital, Capital Medical University, China. Umbilical cord blood was sampled immediately after delivery and fetal acidemia was defined as umbilical cord arterial blood pH < 7...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29859395/determination-of-reference-intervals-for-umbilical-cord-arterial-and-venous-blood-gas-analysis-of-healthy-thoroughbred-foals
#7
Sunita S Jeawon, Lisa M Katz, Noreen P Galvin, Ursula M Fogarty, Vivienne E Duggan
Although umbilical cord blood gas analysis is considered the best way to assess in utero oxygenation in human neonates, there is limited evaluation of this method in equine neonatology. Our objectives were to assess the practicality of obtaining umbilical cord blood gas samples in the field and to determine umbilical cord arterial and venous blood gas reference intervals (RI) for healthy, newborn foals. Thoroughbred foals >320 days gestation from healthy mares with uneventful pregnancies at one stud farm were evaluated...
May 25, 2018: Theriogenology
https://www.readbyqxmd.com/read/29843068/when-should-foetal-ph-measurements-be-performed-after-a-prolonged-deceleration-an-experimental-study-in-a-fetal-sheep-model
#8
H Dupuis, L Ghesquière, Julien De Jonckheere, E Aubry, D Sharma, P Deruelle, L Storme, V Houfflin-Debarge, C Garabedian
OBJECTIVE: The aim of fetal heart rate monitoring during labour is to identify and prevent foetal distress, but its evaluation is not perfect. Fetal scalp blood sampling for pH measurement is one of the second-line methods of monitoring when fetal heart rate is classified as suspicious. This study aims to determine when pH testing should be performed after a prolonged deceleration. STUDY DESIGN: This was an experimental study in a fetal sheep model. A partial umbilical cord occlusion was performed for seven minutes followed by a recuperation period of 30 min...
May 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29797595/no-further-improvement-in-pregnancy-related-outcomes-in-the-offspring-of-mothers-with-pre-gestational-diabetes-in-bavaria-germany-between-2001-and-2016
#9
Andreas Beyerlein, Nicholas Lack, Rüdiger von Kries
AIMS: To investigate whether there has been further improvement in the risk of adverse outcomes in pregnancies in women with diabetes during 2008-2016 in Bavaria, Germany. METHODS: Using cross-sectional data on all 1716 170 deliveries in Bavarian hospitals between 2001 and 2016, we assessed the risks of stillbirth, early neonatal death, preterm delivery, large for gestational age, malformations, low Apgar score and low umbilical cord pH by maternal group with diabetes (gestational, pre-gestational, or none) separately for 2001-2007 and 2008-2016...
May 24, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29786834/assessment-of-lactate-production-as-a-response-to-sustained-intrapartum-hypoxia-in-large-for-gestational-age-newborns
#10
Mehreen Zaigham, Karin Källén, Per Olofsson
INTRODUCTION: Lactate concentration in umbilical cord blood is an important measure of intrapartum anaerobic metabolism. The aim of the study was to compare lactate production of large-for-gestational-age (LGA) fetuses against appropriate-for-gestational-age (AGA) fetuses during hypoxia, in diabetic and non-diabetic mothers. MATERIAL AND METHODS: 17 358 validated paired arterial and venous umbilical cord blood samples taken at birth with a full panel of pH, glucose and lactate were analyzed relative to LGA (n=2789) and AGA (n=14 569)...
May 22, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29772390/pathobiology-of-christianson-syndrome-linking-disrupted-endosomal-lysosomal-function-with-intellectual-disability-and-sensory-impairments
#11
Mallory Kerner-Rossi, Maria Gulinello, Steven Walkley, Kostantin Dobrenis
Christianson syndrome (CS) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. CS is due to loss-of-function mutations in SLC9A6, encoding NHE6, a sodium-hydrogen exchanger involved in the regulation of early endosomal pH. Here we review what is currently known about the neuropathogenesis of CS, based on insights from experimental models, which to date have focused on mechanisms that affect the CNS, specifically the brain...
May 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29760729/ceramic-hollow-fibre-constructs-for-continuous-perfusion-and-cell-harvest-from-3d-hematopoietic-organoids
#12
Mark C Allenby, Asma Tahlawi, José C F Morais, Kang Li, Nicki Panoskaltsis, Athanasios Mantalaris
Tissue vasculature efficiently distributes nutrients, removes metabolites, and possesses selective cellular permeability for tissue growth and function. Engineered tissue models have been limited by small volumes, low cell densities, and invasive cell extraction due to ineffective nutrient diffusion and cell-biomaterial attachment. Herein, we describe the fabrication and testing of ceramic hollow fibre membranes (HFs) able to separate red blood cells (RBCs) and mononuclear cells (MNCs) and be incorporated into 3D tissue models to improve nutrient and metabolite exchange...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29750436/fetal-blood-gas-values-during-fetoscopic-myelomeningocele-repair-performed-under-carbon-dioxide-insufflation
#13
Ahmet A Baschat, Edward S Ahn, Jamie Murphy, Jena L Miller
BACKGROUND: Fetoscopic myelomeningocele (MMC) repair is performed with intrauterine carbon dioxide (CO2 ) insufflation. While lamb experiments have shown significant fetal acidemia following CO2 insufflation corresponding information for human pregnancies is not available. CASES: We performed umbilical venous cord blood sampling in three patients during fetoscopic MMC repair at 25+1, 25+3 and 24+1 weeks gestation. Fetal venous pH at the beginning of CO2 insufflation were 7...
May 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29727787/predicting-umbilical-artery-ph-during-labour-development-and-validation-of-a-nomogram-using-fetal-heart-rate-patterns
#14
Rajeev Ramanah, Sikiyah Omar, Alicia Guillien, Aurore Pugin, Alain Martin, Didier Riethmuller, Nicolas Mottet
OBJECTIVE: Nomograms are statistical models that combine variables to obtain the most accurate and reliable prediction for a particular risk. Fetal heart rate (FHR) interpretation alone has been found to be poorly predictive for fetal acidosis while other clinical risk factors exist. The aim of this study was to create and validate a nomogram based on FHR patterns and relevant clinical parameters to provide a non-invasive individualized prediction of umbilical artery pH during labour...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29720269/acidic-preconditioning-of-endothelial-colony-forming-cells-ecfc-promote-vasculogenesis-under-proinflammatory-and-high-glucose-conditions-in-vitro-and-in-vivo
#15
Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal, Soledad Negrotto
BACKGROUND: We have previously demonstrated that acidic preconditioning of human endothelial colony-forming cells (ECFC) increased proliferation, migration, and tubulogenesis in vitro, and increased their regenerative potential in a murine model of hind limb ischemia without baseline disease. We now analyze whether this strategy is also effective under adverse conditions for vasculogenesis, such as the presence of ischemia-related toxic molecules or diabetes, one of the main target diseases for cell therapy due to their well-known healing impairments...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29720096/celiac-crisis-a-rare-and-profound-presentation-of-celiac-disease-a-case-report
#16
Elizabeth Ann Forrest, Mark Wong, Srinivasa Nama, Siddharth Sharma
BACKGROUND: Celiac crisis is a life-threatening manifestation of celiac disease and is rare in adults, with only a handful of cases documented worldwide and mostly in children. CASE PRESENTATION: A profoundly emaciated 43-year-old female presented with profuse diarrhoea, shortness of breath, left leg swelling with ulceration and immobility (Body Mass Index (BMI) = 14.7 kg/m2 ). The patient had normal anion-gap metabolic acidosis (pH = 7.16) with persisting hypokalemia, hyponatremia, hypomagnesemia and hypophosphatemia...
May 2, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29720036/anaerobic-acidification-of-sugar-containing-wastewater-for-biotechnological-production-of-organic-acids-and-ethanol
#17
Darwin, Wipa Charles, Ralf Cord-Ruwisch
Anaerobic acidification of sugars can produce some useful end-products such as alcohol, volatile fatty acids (e.g. acetate, propionate, and butyrate) and lactic acid. The production of end-products is highly dependent on factors including pH, temperature, hydraulic retention time and the types of sugar being fermented. Results of this current study indicate that the pH and hydraulic retention time played significant roles in determining the end products from the anaerobic acidification of maltose and glucose...
May 3, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29719148/a-flow-adsorption-microcalorimetry-logistic-modeling-approach-for-assessing-heterogeneity-of-bronsted-type-surfaces-application-to-pyrogenic-organic-materials
#18
Omar R Harvey, Burke C Leonce, Bruce E Herbert
Biogeochemical functioning of oxides and pyrogenic organic matter (pyOM) are greatly influenced by surface and deprotonation characteristics. We present an energetics-based, logistic modeling approach for quantifying surface homogeneity (ϕ_surf) and surface acidity (pKa, surf) for Bronsted-type surfaces. The ϕ_surf, pKa, surf and associated deprotonation behavior of pyOM were quantified across feedstock (honey mesquite-HM, pine - PI, cord grass - CG) and heat-treatment-temperatures (HTT; 200-650 oC). At HTT200, lower ϕ_surf [HM (0...
May 2, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29702709/neonatal-outcomes-based-on-duration-of-exposure-to-antenatal-corticosteroids-in-indicated-preterm-deliveries
#19
Chase R Cawyer, Spencer G Kuper, Lisa A Dimperio, Alan T Tita, Joseph R Biggio, Lorie M Harper
OBJECTIVE:  To evaluate how duration of exposure to antenatal corticosteroids (ACSs) prior to delivery affects neonatal outcomes in indicated preterm deliveries. STUDY DESIGN:  This is a retrospective cohort of all indicated singleton preterm deliveries (23-34 weeks) in a single tertiary center from 2011 to 2014 comparing those who received ACS 2 to 7 days versus >7 days prior to delivery. The primary neonatal outcome was a composite of arterial cord pH < 7 or base excess ≤ 12, 5-minute Apgar ≤ 3, cardiopulmonary resuscitation, culture-proven neonatal sepsis, intraventricular hemorrhage grade III/IV, necrotizing enterocolitis, and neonatal death...
April 27, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29702270/adnexal-torsion-during-pregnancy-pregnancy-outcomes-after-surgical-intervention-a-retrospective-case-control-study
#20
Yair Daykan, Rona Bogin, Merav Sharvit, Zvi Klein, Dana Josephy, Meir Pomeranz, Nissim Arbib, Tal Biron-Shental, Ron Schonman
STUDY OBJECTIVE: To investigate the pregnancy and neonatal outcomes of surgical treatment for adnexal torsion (AT) during pregnancy. DESIGN: A retrospective case-control study (Canadian Task Force classification II-2). SETTING: A tertiary care academic medical center. MEASUREMENTS AND MAIN RESULTS: The study group included all parturients who underwent surgery for suspected AT during pregnancy from January 2005 to January 2017...
April 24, 2018: Journal of Minimally Invasive Gynecology
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