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https://www.readbyqxmd.com/read/29643616/labor-analgesia-in-parturients-of-fetal-growth-restriction-having-raised-umbilical-doppler-vascular-indices
#1
Sukhen Samanta, Kajal Jain, Neerja Bhardwaj, Vanita Jain, Preet Mohinder Singh, Sujay Samanta, Veenu Singla, Rini Saha
Background and Aims: Fetuses with abnormal umbilical blood flow are at a higher risk of adverse perinatal outcome than those with normal flow. Epidural analgesia (EA) has shown to decrease villous vascular resistance in preeclamptic women during labor. The present study evaluates the effects of epidural ropivacaine and intramuscular (IM) tramadol on Doppler blood flow in parturients with fetal growth restriction and raised umbilical artery (UmA) blood flow. Material and Methods: In this prospective nonrandomized comparative study, 36 term parturients with sonographic evidence of UmA systolic-diastolic (S-D) ratio ≥3 were enrolled...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29630010/perinatal-outcomes-in-women-with-a-history-of-chronic-hypertension-but-normal-blood-pressures-before-20-weeks-of-gestation
#2
Mallory Youngstrom, Alan Tita, Janatha Grant, Jeff M Szychowski, Lorie M Harper
OBJECTIVE: To compare the perinatal outcomes of normotensive women with those of women with a history of chronic hypertension with normal blood pressures before 20 weeks of gestation, stratifying the latter by whether they were receiving antihypertensive medication. METHODS: We conducted a retrospective cohort study of all singletons with a history of chronic hypertension from 2000 to 2014. Exclusions were blood pressure greater than 140/90 mm Hg before 20 weeks of gestation, fetal anomalies, major medical problems other than hypertension, and diabetes...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29626709/impact-of-the-mode-of-delivery-on-maternal-and-neonatal-outcome-in-spontaneous-onset-breech-labor-at-32-0-36-6-weeks-of-gestation-a-retrospective-cohort-study
#3
Elli Toivonen, Outi Palomäki, Päivi Korhonen, Heini Huhtala, Jukka Uotila
OBJECTIVE: To compare neonatal and maternal outcomes in spontaneously onset preterm breech deliveries after trial of labor (BTOL) and intended cesarean section (BCS), and between BTOL and vertex control deliveries, in singleton fetuses at 32+0 -36+6  weeks of gestation. STUDY DESIGN: Retrospective single center cohort study in a Finnish University Hospital including all spontaneous-onset preterm breech deliveries with 32 completed gestational weeks in 2003-2015...
March 30, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29615483/incidence-of-hypocapnia-hypercapnia-and-acidosis-and-the-associated-risk-of-adverse-events-in-preterm-neonates
#4
Melissa K Brown, Deborah M Poeltler, Kasim O Hassen, Danielle V Lazarus, Vanessa K Brown, Jeremiah J Stout, Wade D Rich, Anup C Katheria
BACKGROUND: Permissive hypercapnia is a lung-protection strategy. We sought to review our current clinical practice for the range of permissive hypercapnia and identify the relationship between P aCO2 and pH and adverse outcomes. METHODS: A secondary analysis of a delayed cord-clamping clinical trial was performed on all arterial blood gas tests in the first 72 h in infants < 32 weeks gestational age. All arterial blood gas values were categorized into a clinical range to determine the percent likelihood of occurring in the total sample...
April 3, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29614446/intrapartum-and-perinatal-results-associated-with-different-degrees-of-staining-of-meconium-stained-amniotic-fluid
#5
Vanesa Rodríguez Fernández, Carlos Nicolás López Ramón Y Cajal, Elena Marín Ortiz, Emilio Couceiro Naveira
OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29582442/relationship-between-fetal-peak-systolic-velocity-in-middle-cerebral-artery-and-umbilical-blood-gas-values-and-hemoglobin-levels-in-diabetic-pregnant-women
#6
Mehmet S Kutuk, Mehmet Dolanbay, Ayse F Gokmen Karasu, Mahmut T Ozgun
PURPOSE: To assess the relationship between peak systolic velocity in the middle cerebral artery (MCA-PSV) and fetal hypoxia in diabetic pregnant women requiring insulin therapy. METHODS: The data of diabetic pregnant women using insulin who were followed in our departments were reviewed retrospectively. The relationships between MCA-PSV and umbilical cord pO2, pCO2, base deficit, hemoglobin, and birth weight were analyzed. RESULTS: A total of 120 cases were included in the final analysis...
March 26, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29581058/nuchal-cord-at-delivery-and-perinatal-outcomes-single-center-retrospective-study-with-emphasis-on-fetal-acid-base-balance
#7
REVIEW
Rohitkumar Vasa, Roger Dimitrov, Shivani Patel
AIM: Our study objectives were to evaluate umbilical cord blood acid-base balance in presence of nuchal cord at delivery, effects of nuchal cord at delivery on perinatal outcomes and incidence of nuchal cord in a racially diverse population. METHODS: Perinatal records of 2530 women (predominantly African American and Hispanic) who delivered in 2012 were examined. Perinatal outcomes of women who delivered a baby with nuchal cord were compared with those without nuchal cord...
March 5, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29577914/the-importance-of-the-learning-process-in-st-analysis-interpretation-and-its-impact-in-improving-clinical-and-neonatal-outcomes
#8
Susanna Timonen, Kaisa Holmberg
BACKGROUND: Intrapartum fetal heart rate (FHR) monitoring was introduced with the goal to reduce fetal hypoxia and deaths. However, continuous FHR monitoring has been shown to have a high sensitivity but also a high false positive rate. To improve specificity, adjunctive technologies have been developed to identify fetuses at risk for intrapartum asphyxia. Intensive research on the value of ST-segment analysis of the fetal electrocardiogram (ECG) as an adjunct to standard electronic fetal monitoring (EFM) in lowering the rates of fetal metabolic acidosis and operative deliveries has been ongoing...
March 22, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29575562/an-evaluation-of-fetal-heart-rate-characteristics-associated-with-neonatal-encephalopathy-a-case-control-study
#9
Heather A Frey, Xiaohua Liu, Courtney D Lynch, Wanjiku Musindi, Philip Samuels, Kara M Rood, Stephen F Thung, Juliana M Bakk, Weiwei Cheng, Mark B Landon
OBJECTIVE: We sought to identify fetal heart rate (FHR) characteristics that are associated with neonatal encephalopathy (NE). DESIGN: Retrospective case-control study. SETTING: A single medical center in Shanghai, China, 2006-2015. SAMPLE: Women delivering a singleton, non-anomalous infant at ≥36 weeks gestation diagnosed with NE (cases, n=109) were compared to a group of women with unaffected infants (controls, n=233)...
March 25, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29551512/endochitinase-1-tv-ech1-from-trichoderma-virens-has-high-subsite-specificities-for-acetylated-units-when-acting-on-chitosans
#10
Franziska Bußwinkel, Oscar Goñi, Stefan Cord-Landwehr, Shane O'Connell, Bruno M Moerschbacher
Chitosans with defined characteristics have been shown to possess reproducible bioactivities for numerous applications. A promising approach for producing chitosans with defined degrees of polymerization (DP), degrees of acetylation (DA), and patterns of acetylation (PA) involves using chitin-modifying enzymes. One such enzyme, the chitinase Tv-ECH1 belonging to the glycoside hydrolase (GH) family 18, seems to have an important role in the biocontrol properties of the fungus Trichoderma virens, suggesting its potential in generating novel chitosans for plant health applications...
March 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29549622/targeted-acid-sensing-ion-channel-therapies-for-migraine
#11
REVIEW
Nazia Karsan, Eric B Gonzales, Gregory Dussor
Acid-sensing ion channels (ASICs) are a family of ion channels, consisting of four members; ASIC1 to 4. These channels are sensitive to changes in pH and are expressed throughout the central and peripheral nervous systems-including brain, spinal cord, and sensory ganglia. They have been implicated in a number of neurological conditions such as stroke and cerebral ischemia, traumatic brain injury, and epilepsy, and more recently in migraine. Their expression within areas of interest in the brain in migraine, such as the hypothalamus and PAG, their demonstrated involvement in preclinical models of meningeal afferent signaling, and their role in cortical spreading depression (the electrophysiological correlate of migraine aura), has enhanced research interest into these channels as potential therapeutic targets in migraine...
March 16, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29531565/evaluation-of-the-predictive-value-of-fetal-doppler-ultrasound-for-neonatal-outcome-from-the-36-th-week-of-pregnancy
#12
Zahra Laleh Eslamian, Elahe Zarean, Maryam Moshfeghi, Zahra Heidari
Background: Early prediction of adverse neonatal outcome would be possible by Doppler impedance indices of middle cerebral artery (MCA), umbilical artery (UmA), and descending aortal artery (AO) that result in decrease neonatal morbidity and mortality rate. The aim of the present study was a determination of optimal value for the ratio of MCA to descending aorta blood flow (MCA/AO) impedance indices and its comparison with the ratio of MCA to UmA (MCA/UmA) impedance indices and their relationship with neonatal outcome...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29529475/exercise-during-pregnancy-is-associated-with-a-shorter-duration-of-labor-a-randomized-clinical-trial
#13
Ruben Barakat, Evelia Franco, María Perales, Carmina López, Michelle F Mottola
OBJECTIVE: to examine the influence of an exercise program throughout pregnancy on the duration of labor in healthy pregnant women. STUDY DESIGN: A randomized clinical trial was used (Identifier: NCT02109588). In all, 508 healthy pregnant women were randomly assigned between 9 and 11 weeks of gestation to either a Control Group (CG, N = 253) or an Exercise Group (EG, N = 255). A moderate aerobic exercise program throughout pregnancy (three weekly sessions) was used as the intervention...
March 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29525100/preparation-and-characterization-of-gelatin-chitosan-nano%C3%AE-tcp-based-scaffold-for-orthopaedic-application
#14
Kanchan Maji, Sudip Dasgupta, Krishna Pramanik, Akalabya Bissoyi
The primary aim of this study was to fabricate gelatin/chitosan/β-TCP (GCT) composite scaffold to improve its compressive mechanical behaviour and in-vivo biocompatibility with predictable degradation rate. Beta tricalcium phosphate (β-TCP) powder was synthesized in size range between 70-100 nm using aqueous precipitation route at a fixed Ca/P molar ratio of 1.5:1 at pH 10 and after subsequent heat treatment of as precipitated powder at 800 °C for 4 hours. The composite scaffolds were fabricated using solid-liquid phase separation of the slurry containing gelatin, chitosan, β-tricalcium phosphate in varying proportion and subsequent lyophilisation of the phase separated mixture...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29523274/an-sflt-1-plgf-ratio-of-655-is-not-a-reliable-cut-off-value-for-predicting-perinatal-outcomes-in-women-with-preeclampsia
#15
Myriam Stolz, Harald Zeisler, Florian Heinzl, Julia Binder, Alex Farr
OBJECTIVES: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is increased in preeclampsia. This study evaluated perinatal outcomes in cases with an sFlt-1:PlGF ratio above 655. STUDY DESIGN: We retrospectively analyzed data from all consecutive women with singleton pregnancies who presented with clinically manifest preeclampsia and underwent immediate sFlt-1:PlGF assessment. Cases with an sFlt-1:PlGF ratio ≥ 655 were matched 1:1 for gestational age to controls with a ratio < 655...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29514530/accuracy-of-the-fetal-cerebroplacental-ratio-for-the-detection-of-intrapartum-compromise-in-nonsmall-fetuses
#16
José Morales-Roselló, Asma Khalil, Victoria Fornés-Ferrer, Alfredo Perales-Marín
OBJECTIVE: To study the accuracy of the cerebroplacental ratio (CPR) for the detection of intrapartum fetal compromise (IFC) in fetuses growing over the 10th centile. METHODS: This was a prospective study of 569 nonsmall fetuses attending the day hospital unit of a tertiary hospital that underwent an ultrasound examination at 36-40 weeks, and were delivered within 4 weeks of examination. IFC was defined as a composite of: abnormal intrapartum fetal heart rate or intrapartum fetal scalp pH < 7...
March 7, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29512897/arterio-venous-differences-in-cord-gas-analysis-and-the-prediction-of-adverse-neonatal-outcome
#17
Liv Knutzen, Christina Aye, Hannah Anderson-Knight, Elena Svirko, Lawrence Impey
INTRODUCTION: The aim of this paper was to determine if arteriovenous differences of pH and PCO2 are useful predictors of adverse neonatal outcome in acidemic neonates. MATERIAL AND METHODS: An established database of 8759 term, singleton, non-anomalous neonates with validated cord gases and outcomes (Encephalopathy (Grade 2/ 3), Apgar <7 at 5 minutes and composite neonatal outcomes of neurological and systemic involvement) was used. Analysis was of the cohort of the 520 acidemic (arterial pH <7...
March 7, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29487351/predicting-the-need-for-home-gavage-or-g-tube-feeds-in-asphyxiated-neonates-treated-with-therapeutic-hypothermia
#18
Suneeti Gupta, Jayapalli Rajiv Bapuraj, Gabrielle Carlson, Emily Trumpower, Ronald E Dechert, Subrata Sarkar
BACKGROUND: Asphyxiated infants treated with therapeutic cooling can have persistent oral feeding difficulty because of involvement of neural pathways in the brainstem, cortex, and basal ganglia. The goal is to predict the composite adverse outcome of death or persistent oral feeding difficulty using precooling/cooling attributes, and the severity and distribution of hypoxic-ischemic lesions, especially brainstem lesions on post-cooling brain magnetic resonance imaging (MRI). METHODS: Retrospective review of 86 asphyxiated infants cooled from January 2006 to August 2014...
February 27, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29479113/does-an-immigrant-background-affect-the-indication-incidence-or-outcome-of-emergency-cesarean-section-results-of-the-prospective-data-collection-of-111-births
#19
Matthias David, Katrin Alexandra Scherer, Wolfgang Henrich, Jürgen Breckenkamp
Objectives: Does the incidence and/or indication(s) for emergency cesarean section differ if the pregnant woman has an immigrant background (IB)? Does a lack of language proficiency (communication problems) and a low acculturation level result in a longer decision-to-delivery interval (D-D interval)? Are neonates born to women with IB by emergency cesarean section in a poorer condition post delivery? Patient cohorts and method: Standardized interviews were carried out before or immediately after delivery in three Berlin obstetric hospitals...
February 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29478084/enhanced-laccase-mediated-transformation-of-diclofenac-and-flufenamic-acid-in-the-presence-of-bisphenol-a-and-testing-of-an-enzymatic-membrane-reactor
#20
Veronika Hahn, Mareike Meister, Stephan Hussy, Arno Cordes, Günther Enderle, Akuma Saningong, Frieder Schauer
The inadequate removal of pharmaceuticals and other micropollutants in municipal wastewater treatment plants, as evidenced by their detection of these substances in the aquatic environment has led to the need for sustainable remediation strategies. Laccases possess a number of advantages including a broad substrate spectrum. To identify promoting or inhibitory effects of reaction partners in the remediation processes we tested not only single compounds-as has been described in most studies-but also mixtures of pollutants...
February 24, 2018: AMB Express
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