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blood glucose fluctuation AND diabetes

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https://www.readbyqxmd.com/read/28418217/24-hour-variations-in-blood-glucose-level-in-type-2-diabetic-japanese-based-on-continuous-glucose-monitoring
#1
Maiko Hajime, Yosuke Okada, Hiroko Mori, Takashi Otsuka, Mayuko Kawaguchi, Megumi Miyazaki, Fumi Kuno, Kei Sugai, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Tadashi Arao, Yoshiya Tanaka
AIMS/INTRODUCTION: High fluctuations in blood glucose are associated with various complications. The correlation between glycated hemoglobin (HbA1c) level and fluctuations in blood glucose level has not been studied in Japanese patients with type 2 diabetes (T2DM). In this study, blood glucose profile stratified by HbA1c level was evaluated by continuous glucose monitoring (CGM) in Japanese T2DM patients. MATERIALS AND METHODS: Our retrospective study included 294 patients with T2DM, who were divided by HbA1c level into five groups (≥6...
April 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28367209/allergy-to-soft-cannula-of-insulin-pump-in-diabetic-patient
#2
Yu-Min Chen, Hui Huang
Insulin pump is a relatively good choice for diabetic patients who require multiple daily injections with wide fluctuations of blood glucose. Patients using insulin pump therapy and still having uncontrolled blood glucose levels for various factors: insulin pump not working properly, insulin instability, insulin autoantibody, insulin allergy, etc. We described a 46-year-old woman with type 2 diabetes and progressive hyperglycemia after switching multiple daily insulin injections to insulin pump, due to allergy to soft cannula of insulin pump...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28326795/digital-health-care-by-in-silico-glycation-of-hba1-blood-cells
#3
James M Minor, Leslie M Rickey, Richard M Bergenstal
BACKGROUND: Diabetes health care relies on the HbA1c (A1c) assay and associated average glucose (AG) to evaluate and control chronic glycemia. However, the A1c assay is plagued with significant noise, lag time, and specificity issues. Current studies support the significant health care advantage of clinical action based on real-time blood glucose (BG) metrics. We seek to improve diabetes management by directly relating such metrics to AG levels as mediated by recently discovered recurrent endocrine cycles...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28326618/comparative-study-of-hba1c-and-fasting-plasma-glucose-vs-the-oral-glucose-tolerance-test-for-diagnosis-of-diabetes-in-people-with-tuberculosis
#4
H Aftab, A Ambreen, M Jamil, P Garred, J H Petersen, S D Nielsen, I C Bygbjerg, D L Christensen
AIM: To compare HbA1c and fasting plasma glucose assessment, with the 2-h oral glucose tolerance test as reference, in screening for diabetes in people with turberculosis. METHODS: Individuals (N=268) with newly diagnosed smear-positive tuberculosis were screened for diabetes at a tertiary hospital in Lahore, Pakistan. Diabetes diagnosis was based on WHO criteria: thresholds were ≥ 48 mmol/mol (≥6.5%) for HbA1c and ≥7.0mmol/l for fasting plasma glucose. RESULTS: The proportion of participants diagnosed with diabetes was 4...
March 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28304392/metrics-for-glycaemic-control-from-hba1c-to-continuous-glucose-monitoring
#5
REVIEW
Boris P Kovatchev
As intensive treatment to lower levels of HbA1c characteristically results in an increased risk of hypoglycaemia, patients with diabetes mellitus face a life-long optimization problem to reduce average levels of glycaemia and postprandial hyperglycaemia while simultaneously avoiding hypoglycaemia. This optimization can only be achieved in the context of lowering glucose variability. In this Review, I discuss topics that are related to the assessment, quantification and optimal control of glucose fluctuations in diabetes mellitus...
March 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28301953/glucose-variability-aggravates-cardiac-fibrosis-by-altering-akt-signalling-path
#6
Changjiang Ying, Ting Liu, Hongwei Ling, Mingyue Cheng, Xiaoyan Zhou, Shanshan Wang, Yizhen Mao, Lei Chen, Runze Zhang, Wei Li
OBJECTIVE: To study the effect of blood glucose variability on cardiac fibrosis and its mechanism in a model of diabetic cardiomyopathy. METHODS: A total of 45 Sprague Dawley rats were randomly divided into three groups: control, control diabetes mellitus and fluctuated blood glucose groups. Fluctuated blood glucose was induced by daily subcutaneous insulin and intraperitoneal glucose injections at different time points. Blood lipids and glycosylated haemoglobin A1c were assessed...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28295770/differences-in-depression-treatment-satisfaction-and-injection-behavior-in-adults-with-type-1-diabetes-and-different-degrees-of-lipohypertrophy
#7
Ingvild Hernar, Johannes Haltbakk, Anders Broström
AIMS AND OBJECTIVES: To assess the prevalence of lipohypertrophy, and to compare differences in external, personal, and regimen factors in adults with type 1 diabetes and different degrees of lipohypertrophy. BACKGROUND: Suboptimal insulin injection behavior is associated with lipohypertrophy, which may affect insulin absorption and lead to blood glucose fluctuations. Few, if any studies have investigated how external, personal, and regimen factors differ in people with type 1 diabetes and different degrees of lipohypertrophy...
March 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28293303/characteristics-of-glucose-metabolism-indexes-and-continuous-glucose-monitoring-system-cgms-in-patients-with-insulinoma
#8
Weijun Gu, Yixin Liu, Hongyan Liu, Guoqing Yang, Qinghua Guo, Jin Du, Nan Jin, Li Zang, Zhaohui Lv, Jianming Ba, Yiming Mu, Jingtao Dou
AIMS: Analyze the clinical applicability of glucose metabolism indexes and continuous glucose monitoring data on the qualitative diagnosis of insulinoma. METHODS: Involve 22 patients with insulinoma (insulinoma group), 11 patients with hypoglycemia (hypoglycemia group) and 31 people with normal glucose tolerance (control group). HbA1c, fasting blood glucose (FBG), insulin (FINS) and C-peptide (FCP) was tested. Using CGMS to monitor the blood glucose for three consecutive days and selecting the monitoring data of 24 h thereof, figuring out, with the aid of EasyGV Version 9...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28282219/a-fixed-ratio-combination-of-insulin-degludec-and-liraglutide-ideglira-reduces-glycemic-fluctuation-and-brings-more-patients-with-type-2-diabetes-within-blood-glucose-target-ranges
#9
Allen B King, Athena Philis-Tsimikas, Eric S Kilpatrick, Irene H Langbakke, Kamilla Begtrup, Tina Vilsbøll
BACKGROUND: Reducing glycemic fluctuation is important for optimal diabetes management. This post hoc analysis examined glycemic fluctuations and the proportion of subjects achieving recommended blood glucose targets with the fixed ratio combination of insulin degludec and liraglutide (IDegLira) compared to insulin degludec (IDeg) and liraglutide alone. METHODS: We analyzed nine-point self-monitored blood glucose (SMBG) profiles from two randomized trials involving IDegLira in patients with type 2 diabetes (T2D), and continuous glucose monitoring (CGM) data from a subset of patients in one of these trials to assess glycemic fluctuation and day-to-day variability...
April 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28280744/glycemic-excursions-in-type-1-diabetes-in-pregnancy-a-semiparametric-statistical-approach-to-identify-sensitive-time-points-during-gestation
#10
Resmi Gupta, Jane Khoury, Mekibib Altaye, Lawrence Dolan, Rhonda D Szczesniak
Aim. To examine the gestational glycemic profile and identify specific times during pregnancy that variability in glucose levels, measured by change in velocity and acceleration/deceleration of blood glucose fluctuations, is associated with delivery of a large-for-gestational-age (LGA) baby, in women with type 1 diabetes. Methods. Retrospective analysis of capillary blood glucose levels measured multiple times daily throughout gestation in women with type 1 diabetes was performed using semiparametric mixed models...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28260702/effects-of-50-mg-vildagliptin-twice-daily-vs-50-mg-sitagliptin-once-daily-on-blood-glucose-fluctuations-evaluated-by-long-term-self-monitoring-of-blood-glucose
#11
Hiroshi Nomoto, Kimihiko Kimachi, Hideaki Miyoshi, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, So Nagai, Takuma Kondo, Tatsuya Atsumi
To date, several clinical trials have compared differences in glucose fluctuation observed with dipeptidyl peptidase-4 inhibitor treatment in patients with type 2 diabetes mellitus. However, most patients were assessed for limited periods or during hospitalization. The aim of the present study was to evaluate the effects of switching from sitagliptin to vildagliptin, or vice versa, on 12-week glucose fluctuations using self-monitoring of blood glucose in the standard care setting. We conducted a multicenter, prospective, open-label controlled trial in Japanese patients with type 2 diabetes...
March 3, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28239763/correlation-between-pre-ramadan-glycemic-control-and-subsequent-glucose-fluctuation-during-fasting-in-adolescents-with-type-1-diabetes
#12
B Afandi, W Kaplan, N Al Hassani, S Hadi, A Mohamed
BACKGROUND: Even though patients with type 1 diabetes mellitus (T1DM) are exempted from fasting, the vast majority elect to fast against the advice of their healthcare providers. We have previously reported the incidence of wide fluctuations in blood glucose (BG) along with "unrecognized" severe hypoglycemia during Ramadan fasting in adolescents with T1DM. This report compares the continuous glucose monitoring (CGM) data during fasting in adolescents with T1DM according to their Pre-Ramadan diabetes control...
February 26, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28238189/retinal-neurodegeneration-in-patients-with-type-1-diabetes-mellitus-the-role-of-glycemic-variability
#13
Fabiana Picconi, Mariacristina Parravano, Dorina Ylli, Patrizio Pasqualetti, Sara Coluzzi, Ilaria Giordani, Ilaria Malandrucco, Davide Lauro, Fabio Scarinci, Paola Giorno, Monica Varano, Simona Frontoni
AIMS: Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified. METHODS: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited...
May 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28213385/effectiveness-of-acarbose-in-treating-elderly-patients-with-diabetes-with-postprandial-hypotension
#14
Jie Zhang, Lixin Guo
: Postprandial hypotension (PPH) is a common condition that occurs primarily in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the effectiveness of acarbose for PPH; it also investigated possible mechanisms behind PPH development. This single-blind, randomized controlled trial included 91 elderly patients with T2DM, aged between 60 and 80 years, who were inpatients at Beijing Hospital between March 2012 and November 2014. The patients were included into one of three groups: Group A, patients with T2DM without PPH; Group B, patients with T2DM with PPH receiving placebo; and Group C, patients with T2DM with PPH receiving acarbose...
February 17, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28183447/acute-low-dose-endotoxin-treatment-results-in-improved-whole-body-glucose-homeostasis-in-mice
#15
Joseph R Stevens, Ryan P McMillan, Justin T Resendes, Shannon K Lloyd, Mostafa M Ali, Madlyn I Frisard, Stefan Hargett, Susanna R Keller, Matthew W Hulver
BACKGROUND: Obese individuals present with an increased inflammatory tone as compared to healthy, normal-weight individuals, which is associated with insulin resistance. One factor hypothesized to contribute to increased inflammation in obese and diabetic states is elevated blood endotoxin levels, a condition known as metabolic endotoxemia. In non-obese and insulin sensitive individuals, circulating endotoxin concentrations fluctuate over the course of the day with elevations in the post-prandial state that return to baseline levels in the post-absorptive state...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28155619/quantification-of-specific-glycation-sites-in-human-serum-albumin-as-prospective-type-2-diabetes-mellitus-biomarkers
#16
Sandro Spiller, Andrej Frolov, Ralf Hoffmann
Type 2 diabetes mellitus (T2DM) is the most common lifestyle disease affecting all countries. Due to its asymptomatic onset, it is often diagnosed after irreversible vascular complications have been initiated. Therefore, specific markers characteristic for very early disease stages and suitable for early diagnostics are required. Glycation of plasma proteins, such as human serum albumin (HSA), has been often suggested as marker. However, the total glycation degree of HSA does not provide sufficient information about short-term fluctuations of blood glucose concentrations due to the large number of glycation sites...
February 2, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28087879/management-of-daily-glycemic-fluctuations-in-patients-with-type-2-diabetes
#17
Pamela R Kushner
Traditional measures of overall glucose control, such as glycated hemoglobin (A1C), may not fully capture short-term, rapid changes in blood glucose. With the availability of multiple options to control A1C, glycemic fluctuations have emerged as an additional therapeutic goal for the management of type 2 diabetes (T2D).
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28065242/advances-in-glycemic-characteristics-complications-and-treatment-for-patients-undergoing-total-pancreatectomy
#18
Ying Zhou, Wei-Gang Zhao
Total pancreatectomy has been mainly used to treat malignant diseases of the pancreas, di-ffuse ductal involvement, and severe chronic pancreatitis. Patients may develop pancreatic diabetes after the surgery, in whom the glucose levels fluctuate widely and are hard to control, which increases the incidence of recurrent hypoglycemia. Postoperative complications are closely associated with the glucose levels. Thus, tighter glycemic management is essential for increasing the survival of these patients. Few cases have been discribed in China...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27956053/poststroke-glycemic-variability-increased-recurrent-cardiovascular-events-in-diabetic-patients
#19
Jee-Eun Yoon, Jun-Sang Sunwoo, Ji Sun Kim, Hakjae Roh, Moo-Young Ahn, Hee-Yeon Woo, Kyung Bok Lee
BACKGROUND AND PURPOSE: The association between blood glucose fluctuation and poststroke cardiovascular outcome has been largely unknown. This study attempted to evaluate whether initial glycemic variability increases cardiovascular events and mortality in diabetic patients with acute ischemic stroke. METHODS: We recruited consecutive patients with acute ischemic stroke or transient ischemic attack from March 2005 to December 2014. A total of 674 patients with diabetes within 72 hours from stroke onset were included...
December 5, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27904549/effects-of-nigella-sativa-supplementation-on-blood-parameters-and-anthropometric-indices-in-adults-a-systematic-review-on-clinical-trials
#20
REVIEW
Alireza Mohtashami, Mohammad Hasan Entezari
BACKGROUND: Nigella sativa (N. sativa) has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. We evaluated the effects of N. sativa supplementation on lipid profiles, glycemic control, blood pressure (BP), and some anthropometric indices in humans. MATERIALS AND METHODS: A search on published studies was done by using databases including PubMed, Google Scholar, Thomas Reuters Web of Science, and Cochrane...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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