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blood glucose fluctuation AND diabetes

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https://www.readbyqxmd.com/read/29687110/challenges-and-perspectives-in-continuous-glucose-monitoring
#1
Benjamin Jasha van Enter, Elizabeth von Hauff
Diabetes is a global epidemic that threatens the health and well-being of hundreds of millions of people. The first step in patient treatment is to monitor glucose levels. Currently this is most commonly done using enzymatic strips. This approach suffers from several limitations, namely it requires a blood sample and is therefore invasive, the quality and the stability of the enzymatic strips vary widely, and the patient is burdened by performing the measurement themselves. This results in dangerous fluctuations in glucose levels often going undetected...
April 24, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29615971/impact-of-glucose-loading-on-variations-in-cd4-and-cd8-t-cells-in-japanese-participants-with-or-without-type-2-diabetes
#2
Aika Miya, Akinobu Nakamura, Hideaki Miyoshi, Yoshinari Takano, Kana Sunagoya, Koji Hayasaka, Chikara Shimizu, Yasuo Terauchi, Tatsuya Atsumi
Objective: The aim of this study was to examine the fluctuations in CD4+ T cells, CD8+ T cells, and natural CD4+ CD25+ FoxP3+ T-regulatory (Treg) cells following an oral glucose tolerance test (OGTT) in participants with and those without type 2 diabetes (T2DM). Methods: 19 Japanese participants with T2DM (DM group) and 21 participants without diabetes (non-DM group) were recruited and underwent a 75-g OGTT. The cell numbers of leukocytes, lymphocytes, and the T cell compartment, such as CD4+ , CD8+ , and Treg, were calculated for blood samples obtained after an overnight 12 h fast and during a 75-g OGTT at 60 and 120 min...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29614124/evaluation-of-glycemic-variability-in-chronic-liver-disease-patients-with-type-2-diabetes-mellitus-using-continuous-glucose-monitoring
#3
Fumi Honda, Akira Hiramatsu, Hideyuki Hyogo, Hiroshi Aikata, Kana Daijo, Yuji Teraoka, Yuki Inagaki, Kei Morio, Tomoki Kobayashi, Takashi Nakahara, Yuko Nagaoki, Tomokazu Kawaoka, Masayasu Yoneda, Masataka Tsuge, Michio Imamura, Yoshiiku Kawakami, Hidenori Ochi, Kazuaki Chayama
BACKGROUND AND AIMS: The feature of blood glucose dynamics in patients with chronic liver disease (CLD) is marked blood glucose fluctuations. However, the detail of blood glucose dynamics is not well known. The aim of the present study was to evaluate glycemic fluctuations by continuous glucose monitoring (CGM). MATERIALS AND METHODS: A total of 105 CLD patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. Various parameters of glycemic variability were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29603806/glucose-concentrations-after-insulin-induced-hypoglycemia-and-glycemic-variability-in-healthy-and-diabetic-cats
#4
Eric Zini, Elena Salesov, Perrine Dupont, Laura Moretto, Barbara Contiero, Thomas A Lutz, Claudia E Reusch
BACKGROUND: Little information is available about posthypoglycemic hyperglycemia (PHH) in diabetic cats, and a causal link between hypoglycemia and subsequent hyperglycemia is not clear. Fluctuations in blood glucose concentrations might only represent high glycemic variability. HYPOTHESIS: Insulin induces PHH in healthy cats, and PHH is associated with poorly regulated diabetes and increased glycemic variability in diabetic cats. ANIMALS: Six healthy cats, 133 diabetic cats...
March 30, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29603547/continuous-glucose-monitoring-during-diabetic-pregnancy-glucomoms-a-multicentre-randomised-controlled-trial
#5
Daphne N Voormolen, J Hans DeVries, Rieneke M E Sanson, Martijn P Heringa, Harold W de Valk, Marjolein Kok, Aren J van Loon, Klaas Hoogenberg, Dick J Bekedam, Teri C B Brouwer, Martina Porath, Ronald J Erdtsieck, Bas NijBijvank, Huib Kip, Olivier W H van der Heijden, Lammy D Elving, Brenda B Hermsen, B J Potter van Loon, Robert J P Rijnders, Henry J Jansen, Josje Langenveld, Bettina M C Akerboom, Rosalie M Kiewiet, Christiana A Naaktgeboren, Ben W J Mol, Arie Franx, Inge M Evers
AIM: Diabetes is associated with a high risk for adverse pregnancy outcomes. Optimal glycaemic control is fundamental and is traditionally monitored with self-measured glucose profiles and periodical HbA1c measurements. We investigated the effectiveness of additional use of retrospective Continuous Glucose Monitoring (CGM) in diabetic pregnancies. MATERIAL AND METHODS: We performed a nation wide multicentre open label randomised controlled trial studying pregnant women with type 1 diabetes, or type 2 diabetes on insulin therapy with gestational age <16 weeks, or insulin treated gestational diabetes with gestational age <30 weeks...
March 30, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29602622/the-application-of-simple-metrics-in-the-assessment-of-glycaemic-variability
#6
REVIEW
L Monnier, C Colette, D R Owens
The assessment of glycaemic variability (GV) remains a subject of debate with many indices proposed to represent either short- (acute glucose fluctuations) or long-term GV (variations of HbA1c ). For the assessment of short-term within-day GV, the coefficient of variation for glucose (%CV) defined as the standard deviation adjusted on the 24-h mean glucose concentration is easy to perform and with a threshold of 36%, recently adopted by the international consensus on use of continuous glucose monitoring, separating stable from labile glycaemic states...
March 6, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29553076/-type-2-diabetes-and-vascular-endothelial-dysfunction
#7
Keiichi Torimoto, Yosuke Okada, Yoshiya Tanaka
Vascular endothelial function is important for maintaining the homeostasis of the living body. Especially, nitric oxide (NO) produced in vascular endothelial cells regulates blood vessel tone and has an antiatherosclerotic effect. Type 2 diabetes is a typical disease that causes impaired vascular endothelial function, resulting in various vascular complications and damage to organs. Cardiovascular disease associated with type 2 diabetes is a chronic inflammatory disease that starts with endothelial dysfunction (ED), and vascular ED is important as an initial change in arteriosclerotic lesions...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/29508275/eadsg-guidelines-insulin-therapy-in-diabetes
#8
Bahendeka Silver, Kaushik Ramaiya, Swai Babu Andrew, Otieno Fredrick, Sarita Bajaj, Sanjay Kalra, Bavuma M Charlotte, Karigire Claudine, Anthony Makhoba
A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. This is usually short-acting insulin or rapid-acting insulin analogue given 0 to 15 min before meals together with one or more daily separate injections of intermediate or long-acting insulin...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29495094/challenges-in-everyday-life-among-recently-diagnosed-and-more-experienced-adults-with-type-2-diabetes-a-multistage-focus-group-study
#9
Cecilia Gardsten, Kerstin Blomqvist, Mikael Rask, Åse Larsson, Agneta Lindberg, Gith Olsson
AIM AND OBJECTIVES: The aim of this study was to identify perceived challenges related to self-management among recently diagnosed adults and those with longer experience of type 2 diabetes as a foundation for the future development of a person-centred information and communication technology service. BACKGROUND: Learning self-management of type 2 diabetes includes mastering the skills required to complete complex emotional and physical tasks. A service developed with the participation of stakeholders may be an alternative way to meet rising needs for self-management...
March 1, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29431385/glucose-management-in-hospitalized-patients
#10
Charles Kodner, Laurie Anderson, Katherine Pohlgeers
Glucose management in hospitalized patients poses challenges to physicians, including identifying blood glucose targets, judicious use of oral diabetes mellitus medications, and implementing appropriate insulin regimens. Uncontrolled blood glucose levels can lead to deleterious effects on wound healing, increased risk of infection, and delays in surgical procedures or discharge from the hospital. Previously recommended strict blood glucose targets for hospitalized patients result in more cases of hypoglycemia without improvement in patient outcomes...
November 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29372110/the-accuracy-of-a-non-invasive-glucose-monitoring-device-does-not-depend-on-clinical-characteristics-of-people-with-type-2-diabetes-mellitus
#11
Tamar Lin, Yulia Mayzel, Karnit Bahartan
Objective: GlucoTrack is a non-invasive device that indirectly measures glucose fluctuation in the earlobe tissue. Thus, its accuracy may be subjected to a time lag between glucose concentration in blood and tissue. This time lag was shown to depend on individual characteristics related to microvascular complications, such as diabetes duration, HbA1c level, and smoking history. Therefore, the current study investigated the effects of these factors on GlucoTrack performance. Research design and methods: Clinical trials were conducted on 114 people with type 2 diabetes...
2018: Journal of Drug Assessment
https://www.readbyqxmd.com/read/29355505/glutazumab-a-novel-long-lasting-glp-1-anti-glp-1r-antibody-fusion-protein-exerts-anti-diabetic-effects-through-targeting-dual-receptor-binding-sites
#12
Caina Li, Miaomiao Yang, Xiaofeng Wang, Hua Zhang, Chenjiang Yao, Sujuan Sun, Quan Liu, Hao Pan, Shuainan Liu, Yi Huan, Shengnan Li, Jun Cao, Xing Wang, Yong Guo, Nan Guo, Shuqian Jing, Cheng Zhang, Zhufang Shen
AIMS: Glucagon like-peptide-1 (GLP-1)-based drugs have been proposed as mono- or combined therapy for type 2 diabetes mellitus. Thus we characterized a novel antibody fusion protein engineered by linking the human GLP-1 derivative to a humanized GLP-1 receptor (GLP-1R) antibody via a peptide linker. MATERIALS AND METHODS: Glutazumab was characterized by receptor binding and reporter activation assays, and its specificity was investigated with the aid of the cognate receptor antagonist exendin (9-39) and antibody Ab1...
April 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29216250/a-randomized-controlled-trial-of-roux-en-y-gastrojejunostomy-vs-gastroduodenostomy-with-respect-to-the-improvement-of-type-2-diabetes-mellitus-after-distal-gastrectomy-in-gastric-cancer-patients
#13
RANDOMIZED CONTROLLED TRIAL
Yoon Young Choi, Sung Hoon Noh, Ji Yeong An
The purpose of this study is to compare the effect of diabetes control induced by Roux-en-Y gastrojejunostomy(RY) vs Billroth-I reconstruction(BI) after distal gastrectomy in patients with early gastric cancer(EGC) and type 2 diabetes(T2DM). Forty EGC patients with T2DM, aged 20-80 years, who were expected to undergo curative distal gastrectomy were randomized 1:1 to RY(n = 20) or BI(n = 20). Diabetes medication status, biochemical and hormonal data including blood glucose, HbA1c, insulin, C-peptide, HOMA-IR, ghrelin, leptin, GLP-1, PYY, and GIP were evaluated for 12 months after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/29069856/association-of-lower-body-mass-index-with-increased-glycemic-variability-in-patients-with-newly-diagnosed-type-2-diabetes-a-cross-sectional-study-in-china
#14
Jian Wang, Rengna Yan, Juan Wen, Xiaocen Kong, Huiqin Li, Peihua Zhou, Honghong Zhu, Xiaofei Su, Jianhua Ma
Previous studies have indicated that the pathogenesis of diabetes differs between obese and lean patients. We investigated whether newly diagnosed Chinese diabetic patients with different body mass indices (BMIs) have different glycemic variability, and we assessed the relationship between BMI and glycemic variability. This was a cross-sectional study that included 169 newly diagnosed and drug-naïve type 2 diabetic patients (mean age, 51.33 ± 9.83 years; 110 men). The clinical factors and results of the 75-g oral glucose tolerance test were all recorded...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29058284/glycemic-index-glycemic-load-and-glycemic-response-to-pomelo-in-patients-with-type-2-diabetes
#15
Shi-Ying Shao, Wei-Jie Xu, Jing Tao, Jian-Hua Zhang, Xin-Rong Zhou, Gang Yuan, Yan Yang, Jing Zhang, Hong-Yan Zhang, Qiang Xu, Xiu-Xin Deng, Shu-Hong Hu, Mu-Xun Zhang, Zhe-Long Liu, Xue-Feng Yu
Food intake has a great influence on blood glucose in patients with diabetes. This study was to determine the glycemic index (GI) and glycemic load (GL) of a particular pomelo named Majia pomelo and its effects on postprandial glucose (PPG) in patients with type 2 diabetes (T2D). Twenty healthy subjects and 20 T2D patients (controlled on lifestyle measures and/or metformin) were tested on 2 separate days with 50 g of glucose and 50 g equivalent of carbohydrates from Majia pomelo for GI measurement. To test effects of Majia pomelo on PPG, 19 hospitalized T2D patients (controlled on insulin therapy) were selected for a 9-day study...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29036213/the-value-of-real-time-continuous-glucose-monitoring-in-premature-infants-of-diabetic-mothers
#16
Hean-Pat Saw, Nai-Wei Yao, Cheng-Di Chiu, Jia-Yuh Chen
To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk of blood sugar abnormalities. Thirty preterm babies (M = 15 and F = 15; ≤ 36 week gestation age) were studied from within 72 hours of delivery. These babies were admitted to the newborn intensive care and were further categorized into groups based on whether their mothers with or without diabetic mellitus. Blood sugar levels were monitored by both RTGMS and the traditional intermittent arterial line (A-Line) glucose method...
2017: PloS One
https://www.readbyqxmd.com/read/29025416/impact-of-renal-function-on-the-underlying-pathophysiology-of-coronary-plaque-composition-in-patients-with-type-2-diabetes-mellitus
#17
Kentaro Kakuta, Kaoru Dohi, Miho Miyoshi, Takashi Yamanaka, Masaki Kawamura, Jun Masuda, Tairo Kurita, Toru Ogura, Norikazu Yamada, Yasuhiro Sumida, Masaaki Ito
BACKGROUND: Both the progression of diabetic kidney disease and increased glycemic variability play important roles in the pathogenesis of coronary plaque formation via inflammatory pathways in patients with type 2 diabetes mellitus (T2DM). Therefore we evaluated the role of renal function in the contributory effects of blood glucose fluctuations and blood levels of inflammatory cytokine concentrations on the tissue characteristics of coronary plaques in patients with T2DM. METHODS: We prospectively enrolled 71 T2DM patients (mean age: 68 ± 9, male 79%) with 153 coronary artery lesions...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28991900/intra-individual-variability-and-circadian-rhythm-of-vascular-endothelial-growth-factors-in-subjects-with-normal-glucose-tolerance-and-type-2-diabetes
#18
Markolf Hanefeld, Katrin Engelmann, Dieter Appelt, Dirk Sandner, Ingo Weigmann, Xenia Ganz, Frank Pistrosch, Carsta Köhler, Antje Gasparic, Andreas L Birkenfeld
Increased levels of systemic vascular endothelial growth factors (VEGFs) in patients with diabetes are associated with increased risk of microvessel disease. On the other hand, low VEGF levels after intravitreal antibody application may be associated with acute cardiovascular complications and treatment failure. Individual levels of systemic VEGF vary in a wide range depending on analytical methods and quality of diabetes control. So far only limited information exists on intraindividual fluctuations over longer periods and circadian rhythms...
2017: PloS One
https://www.readbyqxmd.com/read/28976043/advances-in-ph-sensitive-polymers-for-smart-insulin-delivery
#19
REVIEW
Jing Xie, Anqi Li, Jianshu Li
Since diabetes mellitus has become one of the most serious threats to human health, researchers have been designing new drugs and developing new technologies to control the blood glucose level (BGL) while improving patient compliance. In addition to the traditional subcutaneous injection method, alternative routes of insulin delivery have been investigated and tested, including oral, pulmonary, transdermal, and nasal. The final goal of all these technologies is to develop a system that releases insulin in a controlled manner depending on the BGL...
December 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28924482/atypical-presentation-of-central-pontine-myelinolysis-in-hyperglycemia
#20
Swapna Talluri, Raghu Charumathi, Muhammad Khan, Kerri Kissell
Central pontine myelinolysis (CPM) usually occurs with rapid correction of severe chronic hyponatremia. Despite the pronounced fluctuations in serum osmolality, CPM is rarely seen in diabetics. This is a case report of CPM associated with hyperglycemia. A 45-year-old non-smoking and non-alcoholic African American male with past medical history of type 2 diabetes, hypertension, stage V chronic kidney disease and hypothyroidism presented with a two-week history of intermittent episodes of gait imbalance, slurred speech and inappropriate laughter...
2017: Endocrinology, Diabetes & Metabolism Case Reports
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