keyword
MENU ▼
Read by QxMD icon Read
search

adipocyte maturation

keyword
https://www.readbyqxmd.com/read/28736532/a-memory-of-early-life-physical-activity-is-retained-in-bone-marrow-of-male-rats-fed-a-high-fat-diet
#1
Dharani M Sontam, Mark H Vickers, Elwyn C Firth, Justin M O'Sullivan
Studies have reported opposing effects of high-fat (HF) diet and mechanical stimulation on lineage commitment of the bone marrow stem cells. Yet, how bone marrow modulates its gene expression in response to the combined effects of mechanical loading and a HF diet has not been addressed. We investigated whether early-life (before onset of sexual maturity at 6 weeks of age) voluntary physical activity can modulate the effects of a HF diet on male Sprague Dawley rats. In the bone marrow, early-life HF diet resulted in adipocyte hypertrophy and a pro-inflammatory and pro-adipogenic gene expression profile...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28736524/immune-and-metabolic-regulation-mechanism-of-dangguiliuhuang-decoction-against-insulin-resistance-and-hepatic-steatosis
#2
Hui Cao, Lingling Tuo, Yali Tuo, Ziyun Xia, Rong Fu, Yang Liu, Yihong Quan, Jue Liu, Zhihong Yu, Ming Xiang
Dangguiliuhuang decoction (DGLHD) is a traditional Chinese medicine (TCM) formula, which mainly consists of angelica, radix rehmanniae, radix rehmanniae praeparata, scutellaria baicalensis, coptis chinensis, astragalus membranaceus, and golden cypress, and used for the treatment of diabetes and some autoimmune diseases. In this study, we explored the potential mechanism of DGLHD against insulin resistance and fatty liver in vivo and in vitro. Our data revealed that DGLHD normalized glucose and insulin level, increased the expression of adiponectin, diminished fat accumulation and lipogenesis, and promoted glucose uptake...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28727019/triennial-growth-and-development-symposium-dedifferentiated-fat-cells-potential-and-perspectives-for-their-use-in-clinical-and-animal-science-purpose
#3
M S Duarte, R Bueno, W Silva, C F Campos, M P Gionbelli, S E F Guimarães, F F Silva, P S Lopes, G J Hausman, M V Dodson
An increasing body of evidences has demonstrated the ability of the mature adipocyte to dedifferentiate into a population of proliferative-competent cells known as dedifferentiated fat (DFAT) cells. As early as the 1970s, in vitro studies showed that DFAT cells may be obtained by ceiling culture, which takes advantage of the buoyancy property of lipid-filled cells. It was documented that DFAT cells may acquire a phenotype similar to mesenchymal stem cells and yet may differentiate into multiple cell lineages, such as skeletal and smooth muscle cells, cardiomyocytes, osteoblasts, and adipocytes...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726981/triennial-growth-and-development-symposium-factors-influencing-bovine-intramuscular-adipose-tissue-development-and-cellularity
#4
E Albrecht, L Schering, Y Liu, K Komolka, C Kühn, K Wimmers, T Gotoh, S Maak
Appearance, distribution, and amount of intramuscular fat (IMF), often referred to as marbling, are highly variable and depend on environmental and genetic factors. On the molecular level, the concerted action of several drivers, including hormones, receptors, transcription factors, etc., determines where clusters of adipocytes arise. Therefore, the aim of future studies remains to identify such factors as biological markers of IMF to increase the ability to identify animals that deposit IMF early in age to increase efficiency of high-quality meat production...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726642/coordinated-transcriptional-control-of-adipocyte-triglyceride-lipase-atgl-by-transcription-factors-sp1-and-ppar%C3%AE-during-adipocyte-differentiation
#5
Debasish Roy, Kenneth T Farabaugh, Jing Wu, Alyssa Charrier, Cynthia Smas, Maria Hatzoglou, Kavitha Thirumurugan, David A Buchner
The breakdown of stored fat deposits into its components is a highly regulated process that maintains plasma levels of free fatty acids to supply energy to cells. Insulin-mediated transcription of Atgl, the enzyme that mediates the rate-limiting step in lipolysis, is a key point of this regulation. In conditions such as obesity or insulin resistance, Atgl transcription is often misregulated, which can contribute to overall disease progression. The mechanisms by which Atgl is induced during adipogenesis are not fully understood...
July 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28726396/the-potent-anti-inflammatory-and-anti-adipogenic-properties-of-bamboo-sasa-coreana-nakai-leaves-extract-and-its-major-constituent-flavonoids
#6
Ji Hye Yang, Moon-Hee Choi, Seung Hwa Yang, Sam Seok Cho, Su Jung Park, Hyun-Jae Shin, Sung Hwan Ki
The pro-inflammatory response and recruitment of macrophages into adipose tissue contribute to metabolic dysfunction. Here, we reported the anti-inflammatory and anti-adipogenic effects of the methanol (MeOH) extract and ethylacetate (EtOAc) fraction of bamboo leaf and its molecular mechanism in RAW264.7 cells and 3T3-L1 adipocytes, respectively. Functional macrophage migration assays also were performed. Surprisingly, EtOAc fraction of MeOH extracts from native Korean plant species Sasa coreana Nakai (SCN) has shown potent anti-inflammatory properties; SCN pretreatment inhibited nitric oxide (NO) production (p<0...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28708578/hyperglycemia-and-advanced-glycation-end-products-ages-suppress-the-differentiation-of-3t3-l1-preadipocytes
#7
Chia-Chu Chang, Chen-Yu Chen, Geen-Dong Chang, Ting-Huan Chen, Woan-Ling Chen, Hui-Chin Wen, Chih-Yang Huang, Chung-Ho Chang
Aging is characterized by mild hyperglycemia and accumulation of advanced glycation end products (AGEs). Effects of chronic exposure to hyperglycemia or AGEs on the adipogenic differentiation of 3T3-L1 preadipocytes remain unclear. We examined the chronic effect of AGEs and high glucose on the differentiation of 3T3-L1 cells by culturing 3T3-L1 cells in the presence of AGEs or 25 mM glucose for 1 month. Chronic incubation of 3T3-L1 cells with AGEs or high glucose blocked their differentiation into mature adipocytes as evidenced by reduced levels of adipocyte markers such as accumulated oil droplets, GPDH, aP2, adiponectin and of adipogenesis regulators PPARγ and C/EBPα...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28703289/maresin-1-inhibits-tnf-alpha-induced-lipolysis-and-autophagy-in-3t3-l1-adipocytes
#8
Laura M Laiglesia, Silvia Lorente-Cebrián, Miguel López-Yoldi, Raquel Lanas, J Alfredo Martínez, Maria J Moreno-Aliaga
Obesity is associated with high pro-inflammatory cytokine levels like tumor necrosis factor-alpha (TNF-α), which promotes inflammation in adipose tissue. The omega-3 PUFAs, and their derived lipid mediators, such as Maresin 1 (MaR1) have anti-inflammatory effects on adipose tissue. This study aimed to analyze if MaR1 may counteract alterations induced by TNF-α on lipolysis and autophagy in mature 3T3-L1 adipocytes. Our data revealed that MaR1 (1-100 nM) inhibited the TNF-α-induced glycerol release after 48 h, which may be related to MaR1 ability of preventing the decrease of lipid droplet-coating protein perilipin and G0/G1 Switch 2 protein expression...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28700271/lsd1-a-metabolic-sensor-of-environment-requirements-that-prevents-adipose-tissue-from-aging
#9
Delphine Duteil, Milica Tosic, Roland Schüle
Understanding development and maintenance of beige adipocytes provide exciting insights in establishing novel therapies against obesity and obesity-associated disorders. Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser required for differentiation and function of adipocytes. Lsd1 is involved in early commitment of preadipocytes, but dispensable for terminal differentiation of white adipose tissue (WAT). In mature adipocytes, Lsd1 responds to different environmental stimuli to alter metabolic function and enable proper thermogenic and oxidative response...
June 26, 2017: Adipocyte
https://www.readbyqxmd.com/read/28699004/a-delayed-proinflammatory-response-of-human-preadipocytes-to-pcb126-is-dependent-on-the-aryl-hydrocarbon-receptor
#10
Francoise A Gourronc, Larry W Robertson, Aloysius J Klingelhutz
Inflammation in adipose tissue is recognized as a causative factor in the development of type II diabetes. Adipocyte hypertrophy as well as bacterial and environmental factors have been implicated in causing inflammation in mature adipocytes. Exposure to persistent organic pollutants such as polychlorinated biphenyls (PCBs) has been associated with the development of type II diabetes. We show here that PCB126, a dioxin-like PCB, activates a robust proinflammatory state in fat cell precursors (preadipocytes)...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28683287/the-sense-of-smell-impacts-metabolic-health-and-obesity
#11
Celine E Riera, Eva Tsaousidou, Jonathan Halloran, Patricia Follett, Oliver Hahn, Mafalda M A Pereira, Linda Engström Ruud, Jens Alber, Kevin Tharp, Courtney M Anderson, Hella Brönneke, Brigitte Hampel, Carlos Daniel de Magalhaes Filho, Andreas Stahl, Jens C Brüning, Andrew Dillin
Olfactory inputs help coordinate food appreciation and selection, but their role in systemic physiology and energy balance is poorly understood. Here we demonstrate that mice upon conditional ablation of mature olfactory sensory neurons (OSNs) are resistant to diet-induced obesity accompanied by increased thermogenesis in brown and inguinal fat depots. Acute loss of smell perception after obesity onset not only abrogated further weight gain but also improved fat mass and insulin resistance. Reduced olfactory input stimulates sympathetic nerve activity, resulting in activation of β-adrenergic receptors on white and brown adipocytes to promote lipolysis...
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28674284/c1qtnf-related-protein-1-improve-insulin-resistance-by-reducing-phosphorylation-of-serine-1101-in-insulin-receptor-substrate-1
#12
Yaping Xin, Dongming Zhang, Yanqin Fu, Chongxian Wang, Qingju Li, Chenguang Tian, Suhe Zhang, Xiaodong Lyu
C1qTNF-related protein 1 (CTRP1) is independently associated with type 2 diabetes. However, the relationship between CTRP1 and insulin resistance is still not established. This study aimed to explore the role of CTRP1 under the situation of insulin resistance in adipose tissue. Plasma CTRP1 level was investigated in type 2 diabetic subjects (n = 35) and non-diabetic subjects (n = 35). The relationship between CTRP1 and phosphorylation of multi insulin receptor substrate 1 (IRS-1) serine (Ser) sites was further explored...
July 1, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28672891/osteogenic-potency-of-dedifferentiated-fat-cells-isolated-from-elderly-people-with-osteoporosis
#13
Wei Hao, Chuanqiang Jiang, Ming Jiang, Tian Wang, Xin Wang
Mature adipocytes are the major cell type in adipose tissue. This study aimed to explore the osteogenic potency of dedifferentiated fat cells obtained from osteoporotic patients (opDFATs) in vitro and in vivo. Mature adipocytes and adipose-derived stem cells (opASCs) were harvested from subcutaneous adipose tissue. Mature adipocytes were dedifferentiated to produce opDFATs by the ceiling culture method. OpDFATs were osteogenically induced in vitro with opASCs as a control. Cell growth, alkaline phosphatase (ALPase) activity and cell mineralization were determined, and expression levels of osteogenesis-specific genes (collagen I, osteocalcin and bone sialoprotein) were analyzed using quantitative reverse transcription polymerase chain reaction...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28671279/impairment-of-primary-cilia-contributes-to-visceral-adiposity-of-high-fat-diet-fed-mice
#14
Ni Qiu, Wei-Jin Fang, Hong-Sheng Li, Zhi-Min He, Zhou-Sheng Xiao, Yan Xiong
Deficiency of primary cilia formation by knockout kinesin family member 3A (Kif3a) in mature osteoblasts led to osteopenia and enhanced adipogenesis. Adipogenesis plays an important role in adipose tissue expansion by High-fat-diet (HFD) induced obesity. Whether primary cilia participate in high-fat-diet induced adiposity remains unclear. In this study, we found that the number and length of primary cilia and expression levels of KIF3A and intraflagellar transport 88 homolog (IFT88) mRNA and proteins reached peak on the day 3 of adipogenesis, followed by a decrease to reach low basal expression levels at day 9 when differentiated to lipid accumulating adipocytes in VAT-SVFs derived from lean mice...
July 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28668300/lipid-droplet-growth-and-adipocyte-development-mechanistically-distinct-processes-connected-by-phospholipids
#15
REVIEW
Yanfei Qi, Lei Sun, Hongyuan Yang
The differentiation of preadipocytes into mature adipocytes is accompanied by the growth and formation of a giant, unilocular lipid droplet (LD). Mechanistically however, LD growth and adipogenesis are two different processes. Recent studies have uncovered a number of proteins that are able to regulate both LD dynamics and adipogenesis, such as SEIPIN, LIPIN and CDP-Diacylglycerol Synthases. It appears that phospholipids, phosphatidic acid in particular, play a critical role in both LD budding/growth and adipocyte development...
June 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28665940/adiposity-and-adipogenic-gene-expression-in-four-different-muscles-in-beef-cattle
#16
Lara Martínez Del Pino, Ana Arana, Leopoldo Alfonso, José Antonio Mendizábal, Beatriz Soret
Anatomical site and divergent functionalities of muscles can be related to differences in IMF content, metabolism and adipogenic gene expression. Then, potential differences in different muscles in beef cattle were studied. As a second objective, the main sources of experimental variability associated to RT-qPCR results were analyzed following a nested design in order to implement appropriate experimental designs minimizing gene expression variability. To perform the study Longissimus thoracis (LT), Semitendinosus (SM), Masseter (MS), Sternomandibularis (ST) and subcutaneous adipose tissue (SAT) samples of Pirenaica young bulls (n = 4) were collected for IMF, collagen and protein quantification, analysis of adipocyte size distribution and gene expression (PPARG, CEBPA, FAPB4 and WNT10B)...
2017: PloS One
https://www.readbyqxmd.com/read/28659738/rosmarinic-acid-suppresses-adipogenesis-lipolysis-in-3t3-l1-adipocytes-lipopolysaccharide-stimulated-tumor-necrosis-factor-%C3%AE-secretion-in-macrophages-and-inflammatory-mediators-in-3t3-l1-adipocytes
#17
Yehua Rui, Lingxia Tong, Jinbo Cheng, Guiping Wang, Liqiang Qin, Zhongxiao Wan
Background: Rosmarinic acid (RA) is a natural phenol carboxylic acid with many promising biological effects. It may be a suitable candidate for improving obesity-related adipose tissue dysfunction. Objective: We aimed to investigate the therapeutic use of RA as an anti-obesity agent by measuring its effects on adipogenesis, lipolysis, and messenger RNA (mRNA) expression of major adipokines in 3T3-L1 adipocytes; and its effects on lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) secretion in macrophages and inflammatory mediators in 3T3-L1 adipocytes incubated with macrophage-conditioned medium (MCM)...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28659539/progesterone-dose-dependently-modulates-hepatocyte-growth-factor-production-in-3t3-l1-mouse-preadipocytes
#18
Tomoki Ito, Daisuke Yamaji, Akihiro Kamikawa, Mabrouk Attia Abd Eldaim, Yuko Okamatsu-Ogura, Akira Terao, Masayuki Saito, Kazuhiro Kimura
It is well documented that estrogen is predominant inducer of hepatocyte growth factor (HGF) in a variety of cell types. However, the effect of progesterone (P) remains to be elusive. Thus, in the present study, we examined the effect of P and combined effect of P and 17β-estradiol (E2) on HGF expression and production in 3T3-L1 fibroblastic preadipocytes and mature adipocytes, as a model of stromal cells. Northern blot analysis showed that hgf mRNA expressed in preadipocytes was notably higher than that of mature adipocytes, and increased by treatment of preadipocytes with E2 or 10 nM P, but not with 1,000 nM P...
June 27, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28659368/giant-lipoma-of-the-hand-causing-median-nerve-compression
#19
Kevin Clesham, John Gerard Galbraith, Ashok Ramasamy, Ahmed Karkuri
Lipomas are benign neoplasms derived from adipose tissue composed of mature adipocytes. They account for almost 50% of all soft-tissue neoplasms and occur in up to 2% of the population. They usually present asymptomatically as solitary discrete mobile lumps found most commonly on the neck, upper back, proximal limbs and chest. In less than 1% of cases, they can be found in the distal extremities.We discuss the case of a 65-year-old man who presented with a 2-year history of a slowly enlarging left palm swelling, with recent-onset numbness and loss of power in the distribution of the median nerve...
June 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28655716/increased-adipose-tissue-aromatase-activity-improves-insulin-sensitivity-and-reduces-adipose-tissue-inflammation-in-male-mice
#20
Claes Ohlsson, Ann Hammarstedt, Liesbeth Vandenput, Niina Saarinen, Henrik Ryberg, Sara Windahl, Helen H Farman, John-Olov Janson, Sofia Movérare-Skrtic, Ulf Smith, Fu-Ping Zhang, Matti Poutanen, Shahram Hedjazifar, Klara Sjogren
Females are in general more insulin sensitive than males. To investigate if this is a direct effect of sex-steroids (SS) in white adipose tissue (WAT), we developed a male mouse model over expressing the aromatase enzyme, converting testosterone (T) to estradiol (E2), specifically in WAT (Ap2-arom mice). Adipose tissue E2 levels were increased while circulating SS levels were unaffected in male Ap2-arom mice. Importantly, male Ap2-arom mice were more insulin sensitive compared with WT mice and exhibited increased serum adiponectin levels and upregulated expression of Glut4 and Irs1 in WAT...
June 27, 2017: American Journal of Physiology. Endocrinology and Metabolism
keyword
keyword
119721
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"