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bilirubin AND diabetes

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https://www.readbyqxmd.com/read/28709978/the-severity-grading-of-acute-cholecystitis-following-the-tokyo-guidelines-is-the-most-powerful-predictive-factor-for-conversion-from-laparoscopic-cholecystectomy-to-open-cholecystectomy
#1
M Bouassida, M F Chtourou, H Charrada, S Zribi, L Hamzaoui, M M Mighri, H Touinsi
BACKGROUND: The relationship between the severity assessment of acute cholecystitis based on the Tokyo Guidelines and the risk for conversion from laparoscopic surgery to open surgery has been assessed in few previous reports, with conflicting results. METHODS: A retrospective review of patients with acute cholecystitis within a single system from 2010 to 2013 was performed. The diagnosis and severity of acute cholecystitis were assigned by the Tokyo Guidelines 2013 (TG13)...
July 11, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28691429/effectiveness-of-bariatric-procedures-based-on-selected-laboratory-parameters-of-patients-from-rural-areas-in-polish-population
#2
Regina Sierżantowicz, Jolanta Lewko, Lech Trochimowicz, Bożena Kirpsza, Jacek Dadan, Hady Razak Hady
BACKGROUND: The latter are inhabited by over 15 million people, i.e. 39.5% of Polish population, including about 5 million rural residents in the Podlaskie voivodeship. The incidence of obesity is associated with increased prevalence of obesity-related conditions. The conducted studies do not confirm the efficacy of conservative treatment obesity, but show that bariatric procedures produce the best long-term results. OBJECTIVES: The aim of the study was to present the effects of bariatric obesity treatment (LAGB, SG, RYGB) on body mass index (BMI), selected diabetes control parameters, dyslipidemia, hepatic and renal enzymes, blood count, and hypertension control...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28656099/effects-of-synbiotic-food-consumption-on-serum-minerals-liver-enzymes-and-blood-pressure-in-patients-with-type-2-diabetes-a-double-blind-randomized-cross-over-controlled-clinical-trial
#3
Zatollah Asemi, Mohammad Hossein Aarabi, Mohammad Hajijafari, Sabihe-Alsadat Alizadeh, Reza Razzaghi, Majid Mazoochi, Ahmad Esmaillzadeh
BACKGROUND: This research was to examine the effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D). METHODS: This randomized, cross-over clinical trial was performed among 62 diabetic patients. Persons were randomly assigned to intake either a synbiotic (n = 62) or a control food (n = 62) for 6 weeks. A 3-week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28560862/low-serum-bilirubin-level-predicts-the-development-of-chronic-kidney-disease-in-patients-with-type-2-diabetes-mellitus
#4
Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of 349 patients with T2DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were enrolled. The main outcome was the development of CKD stage 3 or greater...
May 31, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28553763/clinical-characteristics-of-patients-with-diabetes-mellitus-and-fatty-liver-diagnosed-by-liver-spleen-hounsfield-units-on-ct-scan
#5
Kosuke Sakitani, Kenichiro Enooku, Hirokazu Kubo, Akifumi Tanaka, Hisakatsu Arai, Shoji Kawazu, Kazuhiko Koike
Objective The leading cause of liver injuries in diabetes mellitus may be associated with fatty liver. We aimed to elucidate the relationship between fatty liver and diabetes characteristics. Methods Retrospectively, 970 patients with diabetes were analysed. Fatty liver was diagnosed when the liver/spleen Hounsfield unit ratio by computed tomography was below 0.9. Clinical diabetes characteristics were compared between patients with and without fatty liver. Results Of 970 patients (717 male and 253 female; mean age 64...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28523523/serum-bilirubin-levels-are-negatively-associated-with-diabetic-retinopathy-in-patients-with-type-1-diabetes-and-normal-renal-function
#6
Tomislav Bulum, Martina Tomić, Lea Duvnjak
INTRODUCTION: Previous studies suggested that total serum bilirubin levels are negatively associated with diabetic retinopathy (DR) and nephropathy in patients with diabetes mellitus. The objective of this study was to explore the relationship between serum total bilirubin levels and prevalence of DR in patients with type 1 diabetes (T1DM) and normal renal function. METHODS: Study included 163 T1DM with normal renal function (urinary albumin excretion rate <30 mg/24 h, estimated glomerular filtration rate (eGFR) >60 ml min(-1)1...
May 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28403090/anemia-bilirubin-and-cardiovascular-autonomic-neuropathy-in-patients-with-type-2-diabetes
#7
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
To investigate the relationship among anemia, physiological serum bilirubin levels, and cardiovascular autonomic neuropathy (CAN) in subjects with type 2 diabetes. In total, 2230 subjects with type 2 diabetes were evaluated in this cross-sectional study. CAN was diagnosed with a cardiovascular reflex test. The prevalence of anemia was greater in subjects with CAN. In multivariable analysis, the relationship between anemia and CAN remained statistically significant after adjusting for the risk factors (odds ratio [OR] 1...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28392997/fatty-liver-associated-with-metabolic-derangement-in-patients-with-chronic-kidney-disease-a-controlled-attenuation-parameter-study
#8
Chang-Yun Yoon, Misol Lee, Seung Up Kim, Hyunsun Lim, Tae Ik Chang, Youn Kyung Kee, Seung Gyu Han, In Mee Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Sang Hoon Ahn, Shin-Wook Kang, Tae-Hyun Yoo
BACKGROUND: Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients. METHODS: CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years). RESULTS: The median CAP value was 239 (202-274) dB/m. In 195 (41...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28384901/inverse-association-between-serum-bilirubin-levels-and-retinopathy-in-patients-with-type-2-diabetes-mellitus
#9
Divya Karuppannasamy, Raghuram Venkatesan, Lekha Thankappan, Raghuram Andavar, Sundar Devisundaram
INTRODUCTION: Oxidative stress plays a central role in the pathogenesis of Diabetic Retinopathy (DR) and serum bilirubin has been shown to have antioxidant properties. AIM: To investigate the association between serum bilirubin concentration and DR in patients with Type 2 Diabetes Mellitus (DM). MATERIALS AND METHODS: This was a hospital based, cross- sectional study where in 86 patients with Type 2 DM and 30 controls were recruited. The study was conducted at a tertiary care centre in Southern India between January 2014 and December 2014...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28371155/treatment-with-ly2409021-a-glucagon-receptor-antagonist-increases-liver-fat-in-patients-with-type-2-diabetes
#10
Cristina B Guzman, Xiaotian Michelle Zhang, Rong Liu, Arie Regev, Sudha Shankar, Parag Garhyan, Sreekumar G Pillai, Christof Kazda, Naga Chalasani, Thomas A Hardy
AIMS: Glucagon receptor antagonists (GRAs) represent a clinically validated new class of molecules for the treatment of type 2 diabetes (T2D) however these molecules are associated with increases in hepatic aminotransferases. We evaluated whether treatment with LY2409021, a novel, selective GRA, is associated with changes in hepatic fat and other safety parameters related to the benefit-risk profile for chronic use. MATERIALS AND METHODS: Safety and efficacy were assessed in patients with T2D taking metformin and sulfonylurea randomized to LY2409021 20mg (N=65), placebo (N=68), or sitagliptin 100mg (N=41)...
March 31, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28363276/relationship-between-serum-bilirubin-concentrations-and-diabetic-nephropathy-in-shanghai-han-s-patients-with-type-1-diabetes-mellitus
#11
Xu Li, Lei Zhang, Haibing Chen, Kaifeng Guo, Haoyong Yu, Jian Zhou, Ming Li, Qing Li, Lianxi Li, Jun Yin, Fang Liu, Yuqian Bao, Junfeng Han, Weiping Jia
BACKGROUND: Recent studies highlight a negative association between total bilirubin concentrations and albuminuria in patients with type 2 diabetes mellitus. Our study evaluated the relationship between bilirubin concentrations and the prevalence of diabetic nephropathy (DN) in Chinese patients with type 1 diabetes mellitus (T1DM). METHODS: A total of 258 patients with T1DM were recruited and bilirubin concentrations were compared between patients with or without diabetic nephropathy...
March 31, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28355145/histopathological-and-biochemical-assessments-of-costus-afer-stem-on-alloxan-induced-diabetic-rats
#12
Anthoneth Ndidi Ezejiofor, Zelinjo Nkeiruka Igweze, Nnaemeka Arinze Udowelle, Orish Ebere Orisakwe
BACKGROUND: In continuation of our study of the biological activity of the aqueous extract of Costus afer stem used in tradomedicare in Nigeria, this work has investigated the biochemical, nephroprotective, hepatoprotective and protective effects of aqueous extract of C. afer stem on alloxan-induced hyperglycaemic albino Wistar rats. METHODS: Thirty male albino Wistar rats (150-200 g) were weight-matched into six groups of five rats each. Groups 1 and 2 were the normal (non-induced) and toxic (alloxan-induced) controls, respectively...
July 26, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28335416/supplementation-with-phycocyanobilin-citrulline-taurine-and-supranutritional-doses-of-folic-acid-and-biotin-potential-for-preventing-or-slowing-the-progression-of-diabetic-complications
#13
Mark F McCarty
Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Phycocyanobilin (PhyCB), the light-harvesting chromophore in edible cyanobacteria such as spirulina, is a biliverdin derivative that shares the ability of free bilirubin to inhibit certain isoforms of NADPH oxidase...
March 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28229983/establishment-and-application-of-early-risk-stratification-method-for-acute-abdominal-pain-in-adults
#14
Yu Wang, Hong Zhao, Zhen Zhou, Ci Tian, Hong-Li Xiao, Bao-En Wang
BACKGROUND: Acute abdominal pain is a common symptom of emergency patients. The severity was always evaluated based on physicians' clinical experience. The aim of this study was to establish an early risk stratification method (ERSM) for addressing adults with acute abdominal pain, which would guide physicians to take appropriate and timely measures following the established health-care policies. METHODS: In Cohort 1, the records of 490 patients with acute abdominal pain that developed within the past 72 h were enrolled in this study...
March 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28164994/serum-bilirubin-levels-and-risk-of-type-2-diabetes-results-from-two-independent-cohorts-in-middle-aged-and-elderly-chinese
#15
Jing Wang, Yaru Li, Xu Han, Hua Hu, Fei Wang, Xiulou Li, Kun Yang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Cheng, Yuan Liang, Xiaomin Zhang, Huan Guo, Handong Yang, Jianmin Yuan, Woon-Puay Koh, Frank B Hu, Tangchun Wu, An Pan, Meian He
Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly remains unclear. We investigated both cross-sectional and prospective associations between serum bilirubin levels and T2D risk in the Dongfeng-Tongji (DFTJ) cohort, and replicated the prospective findings in a nested case-control study (509 cases and 509 controls) within the Singapore Chinese Health Study (SCHS). In the cross-sectional analysis of DFTJ cohort (15,575 participants with 2,532 diabetes cases), serum bilirubin levels (total, direct and indirect) increased in new on-set diabetes and decreased with the diabetic duration...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28134984/conversion-from-sirolimus-to-everolimus-in-long-term-liver-graft-recipients
#16
Nina Weiler, Nigar Bilge, Sven Troetschler, Johannes Vermehren, Andreas Anton Schnitzbauer, Eva Herrmann, Christoph Sarrazin, Stefan Zeuzem, Martin-Walter Welker
Immunosuppression by inhibition of the mechanistic target of rapamycin (mTOR) is a promising approach after liver transplantation. The mTOR inhibitor sirolimus was used in selected liver graft recipients despite safety concerns and lack of approval. Everolimus is another mTOR inhibitor approved after liver transplantation. It is currently unknown, whether conversion of sirolimus to everolimus is safe in long-term liver graft recipients. Long-term liver graft recipients treated with sirolimus were converted to everolimus...
January 30, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28134328/effect-of-bilirubin-concentration-on-the-risk-of-diabetic-complications-a-meta-analysis-of-epidemiologic-studies
#17
Bo Zhu, Xiaomei Wu, Yifei Bi, Yang Yang
Diabetes can affect many parts of the body and is associated with serious complications. Oxidative stress is a major contributor in the pathogenesis of diabetic complications and bilirubin has been shown to have antioxidant effects. The number of studies on the effect of bilirubin on the risk of diabetic complications has increased, but the results are inconsistent. Thus, we performed a meta-analysis to determine the relationship between bilirubin concentration and the risk of diabetic complications, and to investigate if there was a dose-response relationship...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28119839/risk-factors-for-delirium-during-acute-and-subacute-stages-of-various-disorders-in-patients-admitted-to-rehabilitation-units
#18
Soyeon Jang, Kwang-Ik Jung, Woo-Kyoung Yoo, Myung Hun Jung, Suk Hoon Ohn
OBJECTIVE: To assess the risk factors for delirium in patients admitted to a rehabilitation unit for acute or subacute neurological or musculoskeletal disorders. METHODS: We reviewed the medical records of 537 patients admitted to a rehabilitation unit and selected 398 patients in the acute or subacute stage of various neurological or musculoskeletal disorders. Among them, patients who had suffered from delirium were categorized into the delirium group (n=65), and the other patients were categorized into the non-delirium group (n=333)...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28111217/renoprotective-and-antioxidative-effects-of-methanolic-paederia-foetida-leaf-extract-on-experimental-diabetic-nephropathy-in-rats
#19
M P Borgohain, L Chowdhury, S Ahmed, N Bolshette, K Devasani, T J Das, A Mohapatra, M Lahkar
ETHNOPHARMACOLOGICAL RELEVANCE: Paederia foetida Linn. (Family: Rubiaceae) is widely used as a natural remedy for diabetes mellitus by the Nepali and Lepcha tribes of Sikkim and Darjeeling Himalayan region. The plant is administered to a diabetic individual in the form of leaf infusion for 2-3 weeks. Therefore, we investigated the effects of methanolic leaf extract of Paederia foetida (MEPF) on alloxan (ALX) induced diabetic renal oxidative stress and NF-kB dependent renoinflammatory events in rat...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28093842/gilbert-syndrome-in-patients-with-type-1-diabetes-prevalence-glycemic-control-and-microalbuminuria
#20
Sigal Singer, Nurit Pilpel, Orit Pinhas-Hamiel
BACKGROUND: Gilbert syndrome (GS) is a common hereditary condition, characterized by intermittent unconjugated hyperbilirubinemia. In adults with type 2 diabetes and GS, a markedly lower prevalence of nephropathy was documented, suggesting a beneficial effect of hyperbilirubinemia. We investigated the prevalence of GS among individuals with type 1 diabetes mellitus (T1DM), and the prevalence of microalbuminuria. METHODS: The prevalence of GS was assessed in 401 (204 female) patients with T1DM, median age 21...
January 17, 2017: Pediatric Diabetes
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