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bilirubin AND diabetes

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https://www.readbyqxmd.com/read/29780419/elevated-serum-total-bilirubin-concentrations-are-negatively-associated-with-diabetic-retinopathy-among-the-chinese-northeastern-population
#1
Dan Zhang, Wei Zhang, Shi Jin, Wei Wang, Dan Guo, Lu Wang
Objective: To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods: A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results: A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29752133/usefulness-of-ca-19-9-for-pancreatic-cancer-screening-in-patients-with-new-onset-diabetes
#2
Jung Wan Choe, Hyo Jung Kim, Jae Seon Kim, Jaehyung Cha, Moon Kyung Joo, Beom Jae Lee, Jong-Jae Park, Young-Tae Bak
BACKGROUND: Generally, carbohydrate antigen 19-9 (CA 19-9) is not useful for screening pancreatic cancer in the asymptomatic general population. This study aimed to evaluate the utility of CA 19-9 level as a screening indicator of pancreatic cancer in asymptomatic patients with new-onset diabetes. METHODS: We retrospectively reviewed the medical records of patients who visited our health promotion center for health check-ups without cancer related symptoms from January 2005 to January 2014, and were newly diagnosed with diabetes mellitus (DM) within 2 years before their visit...
April 20, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29750037/simple-score-to-predict-risk-of-hepatocellular-carcinoma-in-chronic-hepatitis-c-patients-with-advanced-fibrosis-after-pegylated-interferon-and-ribavirin-therapy
#3
Ching-Chih Hu, Cheng-Hao Weng, Liang-Che Chang, Chih-Lang Lin, Yen-Ting Chen, Ching-Fang Hu, Man-Chin Hua, Li-Wei Chen, Rong-Nan Chien
Purpose: Eradication of chronic hepatitis C virus (HCV) after interferon-based therapy and its association with the reduction of risk of hepatocellular carcinoma (HCC) in HCV-infected patients with advanced fibrosis is controversial. The study is aimed to develop a simple scoring model for HCC prediction among advanced fibrotic chronic hepatitis C (CHC) patients after pegylated interferon (pegIFN) and ribavirin (RBV) therapy. Patients and methods: We enrolled 271 biopsy-proven CHC patients with advanced fibrosis between 2003 and 2016, and divided them into non-HCC (n=211) and HCC (n=60) groups...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29731435/ethanolic-seeds-extract-of-centratherum-anthelminticum-reduces-oxidative-stress-in-type-2-diabetes
#4
Hina Akram Mudassir, Shamim Akhter Qureshi, Muhammad Bilal Azmi, Muhammad Ahsan
This work was accomplished to assess the in-vitro antiglycation and antioxidant activities of ethanolic seeds extract of Centratherum anthelminticum (CSEt), followed by its in-vivo examination in type 2 diabetes. Overnight fasted rabbits were divided into control and diabetic groups. Rabbits in diabetic group were fed with 35% fructose solution to develop hyperglycemia that was well-monitored by glucometer. These were divided into diabetic control (distilled water 1ml/kg), positive control group (pioglitazone 15mg/kg) and two test groups (CSEt 400 and 600mg treated)...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29710486/synergistic-and-non-synergistic-effects-of-salmon-calcitonin-and-omega-3-fatty-acids-on-antioxidant-anti-inflammatory-and-haematological-indices-in-diabetic-rats
#5
Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
The optimum therapy for the management of diabetes mellitus (DM) has been a controversial issue. Therefore, the study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids {eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); EPA/DHA ratio?=?3/2} relative to metformin in diabetic male Wistar rats. Forty rats were used for this study. They were randomly divided into 8 groups of five (5) rats each, which were treated with single or combined administration of salmon calcitonin, N-3 and metformin...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706999/the-association-between-serum-bilirubin-level-and-electrochemical-skin-conductance-in-chinese-patients-with-type-2-diabetes
#6
Fei Mao, Xiaoming Zhu, Bin Lu, Yiming Li
Bilirubin is an antioxidant and plays a protective role against cardiovascular and microvascular disease. The aim of this study is to explore the possible protective effect of bilirubin on small nerve function. A total of 265 Chinese patients with type 2 diabetes mellitus (T2DM) were enrolled in the study. Both SUDOSCAN and other traditional diabetic neuropathy examinations including neuropathy symptom score (NSS), the neuropathy disability score (NDS) and Michigan Neuropathy Screening Instrument (MNSI) scores were performed in all patients with T2DM...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29670849/ameliorative-activity-of-ethanolic-extract-of-artocarpus-heterophyllus-stem-bark-on-alloxan-induced-diabetic-rats
#7
Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Oluwatosin Adeyonu, Oluwatosin Imiere, Babatunji Emmanuel Oyinloye, Oluwafemi Ogunmodede
Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670682/noninvasive-real-time-characterization-of-renal-clearance-kinetics-in-diabetic-mice-after-receiving-danshensu-treatment
#8
Lei Gao, Yiu-Wa Kwan, Andrew C Bulmer, Christopher W K Lai
Danshensu (DSS) is an active ingredient extracted from the root of the Danshen that could ameliorate oxidative stress via upregulation of heme oxygenase- (HO-) 1. Little is known about the treatment effects of DSS on kidney function in diabetic mice. Therefore, the primary aim of the present study was to characterize the renal clearance kinetics of IRdye800CW in db/db mice after DSS treatment. The secondary aim was to measure several biomarkers of renal function and oxidative stress (urinary F2-isoprostane, HO-1 in kidney and serum bilirubin)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29622904/non-alcoholic-fatty-liver-disease-and-associated-factors-among-type-2-diabetic-patients-in-southwest-ethiopia
#9
Belay Zawdie, Samuel Tadesse, Amare Desalegn Wolide, Tilahun Alemayehu Nigatu, Eshetu Mulisa Bobasa
Background: Non-alcoholic Fatty Liver Disease (NAFLD) among type 2 diabetic patients is completely ignored in developing regions like Africa paving the way for public health and economic burden in the region. Therefore, the main objective of this research was to evaluate non-alcoholic fatty liver disease and associated factors among type 2 diabetic patients in Southwestern Ethiopia attending Diabetic Clinic of Jimma University Specialized Hospital (JUSH). Methods: Facility based cross-sectional study design was used...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29604222/biliary-atresia-clinical-and-research-challenges-for-the-21-st-century
#10
Jorge A Bezerra, Rebecca G Wells, Cara L Mack, Saul J Karpen, Jay H Hoofnagle, Edward Doo, Ronald J Sokol
Biliary atresia (BA) is a fibroinflammatory disease of the intra- and extrahepatic biliary tree. Without medical treatment, surgical hepatic portoenterosmy (HPE) may restore bile drainage, but progression of the intrahepatic disease results in complications of portal hypertension and advanced cirrhosis in most children. Recognizing that further progress in the field is unlikely without a better understanding of the underlying cause(s) and pathogenesis of the disease, the National Institutes of Diabetes and Digestive and Kidney Diseases sponsored a research workshop focused on innovative and promising approaches and on identifying future areas of research...
March 31, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29580009/in-vitro-and-in-vivo-anti-diabetic-and-anti-hyperlipidemic-effects-of-protein-hydrolysates-from-octopus-vulgaris-in-alloxanic-rats
#11
Rabeb Ben Slama-Ben Salem, Naourez Ktari, Intidhar Bkhairia, Rim Nasri, Leticia Mora, Rim Kallel, Safa Hamdi, Kamel Jamoussi, Tahia Boudaouara, Abdelfettah El-Feki, Fidel Toldrá, Moncef Nasri
This study aims to examine the effects of non-hydrolyzed octopus (Octopus vulgaris) muscle proteins (NHOPs) and their hydrolysates (OPHs) on alloxan induced diabetes in Wistar rats (AIDR). Animals were allocated into seven groups of six rats each: control group (C), diabetic group (D) and diabetic rats treated with acarbose (D + Acar), non-hydrolyzed octopus proteins (D + NHOPs) and octopus proteins hydrolysates (D + OPHs) groups. The diabetic rats presented a significant increase in glycemic status such as α-amylase activity (in plasma, pancreas and intestine), hepatic glycogen, blood glucose and glycated hemoglobin (HbA1c) levels, as well as a significant decrease in the levels of plasma insulin and total hemoglobin compared to control group...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29555927/comparison-of-twelve-liver-functional-reserve-models-for-outcome-prediction-in-patients-with-hepatocellular-carcinoma-undergoing-surgical-resection
#12
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Cheng-Yuan Hsia, Chien-Wei Su, Yun-Hsuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Teh-Ia Huo
Various noninvasive liver functional reserve models have been proposed, but their prognostic ability in patients with hepatocellular carcinoma (HCC) is unclear. We aimed to investigate the performance of twelve noninvasive liver reserve models in HCC patients undergoing surgical resection. A total of 645 patients undergoing resection were prospectively identified and retrospectively analyzed. Tumor recurrence, overall survival, and independent prognostic factors were evaluated by the Cox proportional hazards model...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29555465/low-serum-bilirubin-levels-contribute-to-the-presence-and-progression-of-distal-symmetrical-polyneuropathy-in-chinese-patients-with-type-2-diabetes
#13
J Jin, W Wang, T Gu, C Chen, J Sun, W Chen, Y Bi, D Zhu
AIM: To investigate the association between serum bilirubin and distal symmetrical polyneuropathy (DSPN) in Chinese patients with type 2 diabetes (T2D). METHODS: A total of 1800 inpatients with T2D (including 68 with 1-year follow-ups) were consecutively enrolled between June 2014 and March 2017. DSPN was diagnosed according to criteria recommended by the Toronto Diabetic Neuropathy Expert Group in 2010. Clinical data were retrospectively collected. RESULTS: Patients with vs...
February 22, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29545162/birth-weight-gestational-age-and-late-adolescent-liver-function-using-twin-status-as-instrumental-variable-in-a-hong-kong-chinese-birth-cohort-children-of-1997
#14
Jun Xi Liu, Shiu Lun Au Yeung, Man Ki Kwok, June Yue Yan Leung, Shi Lin Lin, Lai Ling Hui, Gabriel Matthew Leung, C Mary Schooling
Birth weight (BW) is inversely associated with diabetes and liver function in Mendelian Randomization studies. Observationally, lower BW is usually also associated with poorer liver function. However, these studies could be confounded by socioeconomic position. Here we assessed if BW is associated with liver function in a unique population with little socio-economic patterning of BW, using both instrumental variable and an observational analysis. We used instrumental variable analysis (IVA) to assess the association of BW with liver function (alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin, and albumin) at ~17 years with twin status as an instrumental variable in the prospective population-representative "Children of 1997" birth cohort (n = 8327)...
June 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29535942/evaluation-of-oxidative-stress-and-proinflammatory-cytokines-in-gestational-diabetes-mellitus-and-their-correlation-with-pregnancy-outcome
#15
K A Sudharshana Murthy, Ambarisha Bhandiwada, Shivani L Chandan, Surakshith L Gowda, G Sindhusree
Background: Prevalence of Gestational Diabetes Mellitus in India is increasing. In addition to performing physiological role in fetoplacental unit during pregnancy, cytokines also play pathophysiological role if expressed in abnormal amounts or sites. Objective: To estimate Proinflammatory Cytokines TNF-α, IL-6, IL-8 and anti-oxidants Glutathione Peroxidase (GTX), Superoxide dismutase (SOD), uric acid and Bilirubin levels in GDM and correlate with pregnancy outcome...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29535057/no-difference-in-effectiveness-of-8-vs-12-weeks-of-ledipasvir-and-sofosbuvir-for-treatment-of-hepatitis-c-in-black-patients
#16
Julia L Marcus, Leo B Hurley, Scott Chamberland, Jamila H Champsi, Laura C Gittleman, Daniel G Korn, Jennifer B Lai, Jennifer O Lam, Mary Patricia Pauly, Charles P Quesenberry, Joanna Ready, Varun Saxena, Suk I Seo, David J Witt, Michael J Silverberg
BACKGROUND & AIMS: Treatment with the combination of ledipasvir and sofosbuvir for 12 weeks has been approved by the Food and Drug Administration for patients with genotype 1 hepatitis C virus (HCV) infection; some patients can be treated with an 8-week course. Guidelines recommend a 12-week treatment course for black patients, but studies have not compared the effectiveness of 8 vs 12 weeks in black patients who are otherwise eligible for an 8-week treatment regimen. METHODS: We conducted an observational study of Kaiser Permanente Northern California members with HCV genotype 1 infection who were eligible for 8 weeks of treatment with ledipasvir and sofosbuvir (treatment-naïve, no cirrhosis, no HIV infection, level of HCV RNA <6 million IU/mL) and were treated for 8 or 12 weeks from October 2014 through December 2016...
June 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29479980/effects-of-cinnamic-acid-on-complications-of-diabetes
#17
Hatice Gül Anlar, Merve Bacanlı, Tuğbagül Çal, Sevtap Aydın, Nuray Arı, Ülkü Ündeğer Bucurgat, Arif Ahmet Başaran, Ayşe Nurşen Başaran
Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay...
February 23, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29443737/effect-of-tenofovir-on-renal-function-in-patients-with-chronic-hepatitis-b
#18
Woo Jin Jung, Jae Young Jang, Won Young Park, Soung Won Jeong, Hee Jeong Lee, Sang Joon Park, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Suyeon Park, Baigal Baymbajav
Tenofovir disoproxil fumarate (TDF) is widely used to treat patients with hepatitis B virus (HBV) infection. We investigated the effect of TDF on renal insufficiency in patients with chronic hepatitis B (CHB).A consecutive cohort analysis was applied to CHB patients taking prescribed TDF from January 2012 to May 2016 at Soonchunhyang University Seoul Hospital. Alterations over time in corrected calcium, phosphate, creatinine, and estimated glomerular filtration rate (eGFR) were analyzed using the generalized estimating equation method...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29395967/factors-correlated-with-serum-insulin-like-growth-factor-i-levels-in-health-check-up-subjects
#19
Ryusaku Matsumoto, Masafumi Koga, Soji Kasayama, Hidenori Fukuoka, Genzo Iguchi, Yukiko Odake, Kenichi Yoshida, Hironori Bando, Kentaro Suda, Hitoshi Nishizawa, Michiko Takahashi, Wataru Ogawa, Yutaka Takahashi
BACKGROUND: Most of circulating IGF-I is derived from the liver and circulating IGF-I levels are decreased in several pathological conditions, such as liver cirrhosis, uncontrolled diabetes, renal failure, and malnutrition. However, it has not fully been elucidated which factors modify IGF-I level in a physiological condition. OBJECTIVE: To identify the factors which are associated with circulating IGF-I levels. DESIGN: Cross-sectional study...
January 30, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29390925/diagnostic-criteria-and-contributors-to-gilbert-s-syndrome
#20
Karl-Heinz Wagner, Ryan G Shiels, Claudia Anna Lang, Nazlisadat Seyed Khoei, Andrew C Bulmer
Hyperbilirubinemia is a well-known condition in the clinical setting; however, the causes of elevated serum bilirubin are diverse, as are the clinical ramifications of this condition. For example, diagnoses of individuals vary depending on whether they exhibit an unconjugated or conjugated hyperbilirubinemia. Diagnoses can include conditions of disordered bilirubin metabolism (Gilbert's, Crigler-Najjar, Rotor, or Dubin-Johnson syndromes) or an acquired disease, including alcoholic/non-alcoholic fatty liver disease, hepatotropic hepatitis, cirrhosis, or hepato-biliary malignancy...
March 2018: Critical Reviews in Clinical Laboratory Sciences
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