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bilirubin AND diabetes

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https://www.readbyqxmd.com/read/27933515/serum-bilirubin-concentrations-and-incident-coronary-heart-disease-risk-among-patients-with-type-2-diabetes-the-dongfeng-tongji-cohort
#1
Jing Wang, Xiaofen Wu, Yaru Li, Xu Han, Hua Hu, Fei Wang, Caizheng Yu, Xiulou Li, Kun Yang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Chen, Yuan Liang, Huan Guo, Handong Yang, Tangchun Wu, Xiaomin Zhang, Meian He
AIMS: Elevated serum bilirubin levels are associated with decreased coronary heart disease (CHD) risk in cross-sectional studies among diabetic patients, but prospective evidence is limited. We investigated the relationship of serum bilirubin levels with incident CHD risk among type 2 diabetes patients. METHODS: In a prospective study of 2918 type 2 diabetes embedded in the Dongfeng-Tongji cohort, serum total bilirubin (TBil), direct bilirubin (DBil), and indirect bilirubin (IBil) were measured at baseline...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27891331/association-of-diabetic-nephropathy-and-liver-disorders
#2
Usha Sachidananda Adiga, B N Malawadi
INTRODUCTION: Liver disorder is known to be a risk factor for Diabetes Mellitus (DM) and diabetic patients are at risk of developing liver disorders. Association of liver and renal disease is less explored in the field of research; hence, we conducted a retrospective study on this. AIM: To compare the renal and liver profiles of type II DM patients compared to healthy controls and find the association between the two profiles in diabetics. MATERIALS AND METHODS: The renal and liver profiles of 68 type II DM patients and 58 controls were compared...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27865613/hyperglycemia-oxidative-stress-liver-damage-and-dysfunction-in-alloxan-induced-diabetic-rat-are-prevented-by-spirulina-supplementation
#3
Manel Gargouri, Christian Magné, Abdelfattah El Feki
Medicinal plants have long been used against life-threatening diseases including diabetes, with more or less success. Some of these plants have been shown to possess antioxidant activities, which could help improving diabetes inconveniences. In that context, we investigated the effects of spirulina supplementation on alloxan-induced diabetic rats, hypothesizing that co-administration of spirulina with rat diet could ameliorate diabetes complications and provide as benefits as the common antidiabetic insulin...
October 4, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27852844/bilirubin-levels-are-associated-with-contrast-induced-nephropathy-in-peripheral-artery-disease
#4
Ertan Vuruşkan, Erhan Saraçoğlu
The relationship between contrast-induced nephropathy (CIN) and oxidative mechanisms is well documented. Our aim was to demonstrate the possible relationship between CIN and serum bilirubin as an antioxidant molecule. This retrospective study included 359 patients with peripheral artery disease (PAD) who underwent peripheral diagnostic angiography; 179 developed CIN after the intervention and another 180 were the control group, matched for age, gender, and cardiovascular risk factors. Baseline, 48- to 72-hour, and 30-day laboratory values, major adverse cardiovascular events, and dialysis requirements were recorded...
November 15, 2016: Angiology
https://www.readbyqxmd.com/read/27847209/in-vivo-study-for-anti-hyperglycemic-potential-of-aqueous-extract-of-basil-seeds-ocimum-basilicum-linn-and-its-influence-on-biochemical-parameters-serum-electrolytes-and-haematological-indices
#5
Sachin Chaudhary, Amit Semwal, Hitesh Kumar, Harish Chandra Verma, Amit Kumar
The study introduced anti-hyperglycemic influence of aqueous extract of Ocimum basilicum seeds (AEOBS) in Streptozotocin (STZ) induced diabetic rats and estimating its potential to ameliorate altered level of biochemical parameters, serum electrolytes level and haematological indices along with its effect on body weight of treated rats. The albino rats were selected to observe oral glucose tolerance test by oral intake of aq. glucose solution (4g/kg, body weight) in normal rats and estimation of blood glucose level after administration of AEOBS at 250mg/kg, 500mg/kg and standard drug glibenclamide at 0...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27821168/associations-of-proteins-relevant-to-mapk-signaling-pathway-p38mapk-1-hif-1-and-ho-1-with-coronary-lesion-characteristics-and-prognosis-of-peri-menopausal-women
#6
Liqiu Yan, Xufen Cao, Saitian Zeng, Zhe Li, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Yanshen Li
BACKGROUND: The present study was intended to explore whether three proteins within MAPK signaling pathway (i.e. p38MAPK-1, HIF-1 and HO-1) were correlated with peri-menopausal women's coronary lesion features and prognosis. METHODS: Altogether 1449 peri-menopausal women were divided into non-coronary artery disease (CAD) group (n = 860) and CAD group (n = 589), including 167 pre-menopausal CAD populations and 422 post-menopausal CAD populations. General information about CAD risk parameters were gathered, including age, family history of CAD or hypertension or diabetes mellitus, bilirubin, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) and so on...
November 8, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27812304/a-comparative-evaluation-of-the-analytical-performances-of-capillarys-2-flex-piercing-tosoh-hlc-723-g8-premier-hb9210-and-roche-cobas-c501-tina-quant-gen-2-analyzers-for-hba1c-determination
#7
Xiaobin Wu, Yan Chao, Zemin Wan, Yunxiu Wang, Yan Ma, Peifeng Ke, Xinzhong Wu, Jianhua Xu, Junhua Zhuang, Xianzhang Huang
INTRODUCTION: Haemoglobin A1c (HbA1c) is widely used in the management of diabetes. Therefore, the reliability and comparability among different analytical methods for its detection have become very important. MATERIALS AND METHODS: A comparative evaluation of the analytical performances (precision, linearity, accuracy, method comparison, and interferences including bilirubin, triglyceride, cholesterol, labile HbA1c (LA1c), vitamin C, aspirin, fetal haemoglobin (HbF), and haemoglobin E (Hb E)) were performed on Capillarys 2 Flex Piercing (Capillarys 2FP) (Sebia, France), Tosoh HLC-723 G8 (Tosoh G8) (Tosoh, Japan), Premier Hb9210 (Trinity Biotech, Ireland) and Roche Cobas c501 (Roche c501) (Roche Diagnostics, Germany)...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27805038/interactive-effect-of-serum-uric-acid-and-total-bilirubin-for-cardiovascular-disease-in-chinese-patients-with-type-2-diabetes
#8
Yanfeng Ren, Nan Jin, Tianpei Hong, Yiming Mu, Lixin Guo, Qiuhe Ji, Qiang Li, Xilin Yang, Linong Ji
Serum uric acid (SUA) at high levels and bilirubin at low levels were potent antioxidant but it was uncertain that whether SUA and total bilirubin (TBIL) had additive interaction for the risk of CVD in type 2 diabetes mellitus (T2DM). We conducted a cross-sectional survey of 6713 inpatients with T2DM and admitted to 81 tertiary care hospitals. CVD was defined as having either prior coronary heart disease or stroke or peripheral arterial disease. Binary logistic regression was used to estimate odds ratios of SUA and TBIL for CVD...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27784430/-prognostic-value-of-a-logistic-regression-model-based-on-keratin-18-in-patients-with-hbv-related-liver-failure
#9
Q R Gan, X Y Jiang, X Zhang, M S Chen, C Pan
Objective: To investigate the association between serum keratin 18 (K18) level and prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). Methods: A total of 120 patients who visited Department of Hepatology in Fuzhou Infectious Disease Hospital and were diagnosed with HBV-related ACLF from December 2012 to March 2014 were enrolled and followed up for 3 months. The patients were divided into death group and survival group. The serum levels of K18 fragments (M30 and M65) were measured and related laboratory data were collected to analyze the differences in M30, M65, M30/M65, and other laboratory markers...
July 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27761078/postprandial-antihyperglycemic-and-antioxidant-activities-of-acalypha-indica-linn-stem-extract-an-in-vivo-study
#10
Charles Lekhya Priya, K V Bhaskara Rao
BACKGROUND: α-glucosidase inhibitors controls postprandial hyperglycemia (PPHG) by lowering sharp rise in blood glucose levels after ingestion of carbohydrate rich meal in type 2 diabetic (T2D) individuals. Acalypha indica commonly known as Indian copper leaf is used in traditional medicinal system to treat various diseases. In our previous in-vitro investigation, methanolic extract of A. indica stems (AIS) proved to be an effective a-glucosidase inhibitor, antioxidant, and well tolerated in acute and subchronic toxicity studies in albino wistar rats...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27726090/higher-direct-bilirubin-levels-during-mid-pregnancy-are-associated-with-lower-risk-of-gestational-diabetes-mellitus
#11
Chaoqun Liu, Chunrong Zhong, Xuezhen Zhou, Renjuan Chen, Jiangyue Wu, Weiye Wang, Xiating Li, Huisi Ding, Yanfang Guo, Qin Gao, Xingwen Hu, Guoping Xiong, Xuefeng Yang, Liping Hao, Mei Xiao, Nianhong Yang
Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression...
October 11, 2016: Endocrine
https://www.readbyqxmd.com/read/27723227/different-effects-of-basal-insulin-peglispro-and-insulin-glargine-on-liver-enzymes-and-liver-fat-content-in-patients-with-type-1-and-type-2-diabetes
#12
K Cusi, A J Sanyal, S Zhang, B J Hoogwerf, A M Chang, S J Jacober, J M Bue-Valleskey, A N Higdon, E J Bastyr, A Haupt, M L Hartman
AIMS: To compare effects of basal insulin peglispro (BIL), a hepatopreferential insulin, to insulin glargine (glargine) on aminotransferases and liver fat content (LFC) in patients with type 1 and type 2 diabetes (T1D, T2D). MATERIALS AND METHODS: Data from two Phase 2 and five Phase 3 randomized trials comparing BIL and glargine in 1709 T1D and 3662 T2D patients were integrated for analysis of liver laboratory tests. LFC, measured by magnetic resonance imaging (MRI) at baseline, 26 and 52 weeks, was analyzed in 182 T1D patients, 176 insulin-naïve T2D patients and 163 T2D patients previously treated with basal insulin...
October 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27668038/properties-of-flavonoids-isolated-from-the-bark-of-eysenhardtia-polystachya-and-their-effect-on-oxidative-stress-in-streptozotocin-induced-diabetes-mellitus-in-mice
#13
Rosa Martha Perez-Gutierrez, Abraham Heriberto Garcia-Campoy, Alethia Muñiz-Ramirez
Six new flavonoids 2',4'-dihydroxychalcone-6'-O-β-d-glucopyranoside (1), α,3,2',4'-tetrahydroxy-4-methoxy-dihydrochalcone-3'-C-β-glucopyranosy-6'-O-β-d-glucopyranoside (2), 7-hydroxy-5,8'-dimethoxy-6'α-l-rhamnopyranosyl-8-(3-phenyl-trans-acryloyl)-1-benzopyran-2-one (3), 6'7-dihydroxy-5,8-dimethoxy-8(3-phenyl-trans-acryloyl)-1-benzopyran-2-one (4), 9-hydroxy-3,8-dimethoxy-4-prenylpterocarpan (5), and α,4,4'-trihydroxydihydrochalcone-2'-O-β-d-glucopyranoside (6) were isolated from bark of Eysenhardtia polystachya...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27662781/elevated-serum-total-bilirubin-levels-are-negatively-associated-with-major-diabetic-complications-among-chinese-senile-diabetic-patients
#14
Miao Liu, Yihe Li, Jiaqi Li, Xianyu Lv, Yao He
AIMS: This study aimed to evaluate the association between total bilirubin (TBiL) and major diabetic complications among Chinese senile diabetic patients. METHODS: A cross-sectional study was conducted in all the cadre sanitariums in Beijing, between May 2012 and December 2014. All the diagnoses of diabetic complications were extracted from the medical records including chronic kidney disease, retinopathy, peripheral vascular disease, coronary heart disease, and ischemic stroke...
August 28, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27571522/the-negative-relationship-between-bilirubin-level-and-diabetic-retinopathy-a-meta-analysis
#15
Bo Zhu, Xiaomei Wu, Kang Ning, Feng Jiang, Lu Zhang
OBJECTIVES: Findings on the relationship between total bilirubin level (TBL) and diabetic retinopathy (DR) are inconsistent. Thus, we carried out a meta-analysis to investigate the relationship between TBL and the risk of DR. METHODS: Relevant studies were selected from six databases up to 31 May 2016 using a search strategy. The relevant data were extracted from the included studies according to the inclusion and exclusion criteria, and the mean value with standard errors or odds ratio (OR) with 95% confidence intervals (CIs) were calculated...
2016: PloS One
https://www.readbyqxmd.com/read/27547293/hyperbilirubinemia-protects-against-aging-associated-inflammation-and-metabolic-deterioration
#16
Jaroslav Zelenka, Aleš Dvořák, Lukáš Alán, Marie Zadinová, Martin Haluzík, Libor Vítek
Mild constitutive hyperbilirubinemia is associated with a reduced risk of cardiovascular diseases, diabetes, and cancer. Since these pathologies are associated with aging, inflammation, and oxidative stress, we investigated whether hyperbilirubinemia interferes with ROS homeostasis in cell cultures and with inflammation, senescence, and mitochondrial dysfunction in aged rats. Human embryonic kidney cells and rat primary fibroblasts showed a dose-dependent decrease in the ratio of oxidized/reduced glutathione, intracellular H2O2 levels, and mitochondrial ROS production, with increasing bilirubin concentrations in the culture media...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27513273/hepatoprotective-and-antidiabetic-activities-of-fraxinus-angustifolia-vahl-extracts-in-animal-models-characterization-by-high-performance-liquid-chromatography-analysis
#17
Zineb Medjahed, Dina Atmani-Kilani, Marie-Laure Fauconnier, Gaëtan Richard, Djebbar Atmani
BACKGROUND/AIM: The present study was designed to explore antidiabetic and hepatoprotective potentials of Fraxinus angustifolia leaf (FAL) and bark (FAB) extracts in vivo. MATERIALS AND METHODS: Streptozotocin (STZ)-induced diabetic rats, pretreated with the extracts (25 and 50 mg/kg), were monitored for fasting blood glucose (FBG) levels. Hepatoprotective potential was examined after injection of an excessive dose of paracetamol (10 g/60 kg) by analysis of biochemical parameters (transaminases, bilirubin), malondialdehyde (MDA) levels, and histological sections...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27508607/-op-1d-09-liver-damage-due-to-diabetes-involves-multiple-pathways-and-induces-microcirculation-alterations-the-effect-of-metformin-plus-insulin-treatment
#18
A Daliry, R Rangel Silvares, E N G da Silva Pereira, E E Ilaquita Flores, V Estato, P A Reis, I José da Silva, M P Machado, H C de Castro F Neto, E Tibiriça
OBJECTIVE: As several studies have shown a link between T1D and liver disease we explored the hepatic alterations due to diabetes and the modulation of this complication by the metformin adjunct therapy. DESIGN AND METHOD: Fifty five Wistar rats were divided in three groups: control (CTL, n = 20), high-fat diet/streptozotocin induced diabetic (DM, n = 20) and diabetic treated with metformin plus insulin (DM + Met + Ins, n = 15). The biochemical parameters (%HbA1c, cholesterol, fructosamine, triglycerides, total proteins, bilirubin, urea, uric acid, and ALT, AST, ALP, GGT, and amylase activities) were analyzed by spectrophotometry...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27457076/gallbladder-small-cell-carcinoma-a-case-report-and-literature-review
#19
Toshiyuki Adachi, Masashi Haraguchi, Junji Irie, Tomoko Yoshimoto, Ryohei Uehara, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Nobuhiro Tada, Masataka Hirabaru, Keiji Inoue, Shigeki Minami, Susumu Eguchi
Gallbladder small cell carcinoma (SCC) comprises only 0.5 % of all gallbladder cancer and consists of aggressive tumors with poor survival outcomes against current treatments. These tumors are most common in elderly females, particularly those with cholecystolithiasis. We report the case of a 79-year-old woman with gallbladder small cell carcinoma. The patient had intermittent right upper quadrant abdominal pain and was admitted to our hospital due to suspected acute cholecystitis. She regularly received medical treatment for diabetes, hypertension, and dyslipidemia...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27435530/extracorporeal-membrane-oxygenation-as-a-bridge-to-lung-re-transplantation-is-there-a-role
#20
J W Awori Hayanga, Jonathan K Aboagye, Heather K Hayanga, James D Luketich, Jonathan D'Cunha
BACKGROUND: In this study we sought to determine survival rates after use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung re-transplantation (re-LT). METHODS: Propensity-adjusted analysis was performed on data from the Scientific Registry of Transplant Recipients (SRTR) to evaluate survival in recipients between the years 1988 and 2012, based on the use of ECMO before re-LT. RESULTS: A total of 854 adult re-LT recipients were identified...
July 2016: Journal of Heart and Lung Transplantation
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