Joshua D Smith, Emily L Bellile, Susan E Ellsperman, Molly E Heft-Neal, Jacqueline E Mann, Andrew C Birkeland, Rebecca C Hoesli, Paul L Swiecicki, Francis P Worden, Caitlin Schonewolf, Jennifer L Shah, Michelle L Mierzwa, Andrew J Rosko, Chaz L Stucken, Steven B Chinn, Andrew G Shuman, Keith A Casper, Kelly M Malloy, Mark E P Prince, Gregory T Wolf, Dafydd G Thomas, Jonathan B McHugh, J Chad Brenner, Matthew E Spector
OBJECTIVES: In an evolving era of immunotherapeutic options for persistent or recurrent laryngeal squamous cell carcinoma (LSCC), there is a need for improved biomarkers of treatment response and survival to inform optimal treatment selection and prognostication. Herein, our primary objective was to explore correlations between tumor infiltrating lymphocytes (TILs) and PD-L1 Combined Positive Score (CPS). Secondarily, we sought to explore their combined association with survival outcomes in patients with persistent or recurrent LSCC treated with salvage surgery...
October 28, 2022: Oral Oncology